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ZC3HAV1 Gene

protein-coding   GIFtS: 50

GC07M138378
zinc finger CCCH-type, antiviral 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for ZC3HAV1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
DKFZp686F2052 2
DKFZp686H1869 2
DKFZp686O19171 2
FLB6421 1, 2, 5
FLJ13288 1, 2, 5
MGC48898 1, 2
ZAP 1, 2, 3, 5
ZC3H2 1, 2
ZC3HDC2 1, 2, 3
Descriptions
CCCH-type zinc finger antiviral protein 2
Zinc finger CCCH domain-containing protein 2 3
Zinc finger antiviral protein 2, 3
zinc finger CCCH type, antiviral 1 2
zinc finger CCCH-type, antiviral 1 2
External Ids
HGNC: 237211
Entrez Gene: 568292
UniProtKB: Q7Z2W43
Ensembl: ENSG000001059397
Search outside databases for aliases for ZC3HAV1 gene

Previous GC identifers: GC07M138142 GC07M138185

Summaries
for ZC3HAV1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for ZC3HAV1:
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by
retroviruses. Studies of the rat homolog indicate that the protein may primarily function to
inhibit viral gene expression and induce an innate immunity to viral infection. Alternative
splicing occurs at this locus and two variants, each encoding distinct isoforms, are described.
[provided by RefSeq]

UniProtKB/Swiss-Prot: ZCCHV_HUMAN, Q7Z2W4
Function: Induces an innate immunity to viral infections by preventing the accumulation of viral
RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs.
Inhibits alphavirus and filovirus replication (By similarity)

Gene Wiki entry for ZC3HAV1

Genomic Location
for ZC3HAV1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZC3HAV1 gene  

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

ZC3HAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M138378:     (about GC identifiers)

Start:
 138,378,806 bp from pter
End:
 138,445,005 bp from pter
Size:
 66,200 bases
Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 138,072,485-138,139,025     
RefSeq DNA sequence:
NC_000007.12  NT_007933.14  NT_079596.2  

Proteins
for ZC3HAV1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ZCCHV_HUMAN, Q7Z2W4 (See protein sequence)
Recommended Name: Zinc finger CCCH-type antiviral protein 1  
Size: 902 amino acids; 101431 Da
Subunit: Interacts with EXOSC5 (By similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but
shuttles between nucleus and cytoplasm in a XPO1-dependent manner (By similarity)
Secondary accessions: A4D1R2 A4D1S4 Q8IW57 Q8TAJ3 Q96N79 Q9H8R9 Q9P0Y7
Alternative splicing: 5 isoforms:  Q7Z2W4-1   Q7Z2W4-2   Q7Z2W4-3   Q7Z2W4-4   Q7Z2W4-5   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_064504.2  NP_078901.3  


    ENSEMBL proteins: 
    ENSP00000242351 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZCCHV)
    Human Recombinant Proteins from Abnova (ZC3HAV1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for ZC3HAV1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZCCHV), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ZC3HAV1

    Assays for ZC3HAV1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ZC3HAV1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR000571 Znf_CCCH
     IPR004170 WWE-dom
     IPR012317 PARP_catalytic


       GeneDecks  ZC3HAV1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q7Z2W4

    ProtoNet protein and cluster: Q7Z2W4

    1 Blocks protein family: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: ZCCHV_HUMAN, Q7Z2W4
    Domain: The second and fourth zinc fingers are involved in binding to specific viral RNAs (By
    similarity)
    Similarity: Contains 4 C3H1-type zinc fingers
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 WWE domain

    Gene Function
    for ZC3HAV1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ZC3HAV1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZC3HAV1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024625

                  Applied Biosystems Silencer® siRNAs for ZC3HAV1

                  Sigma-Aldrich siRNA and siRNA Panels for ZC3HAV1  
                         Sigma-Aldrich shRNA for ZC3HAV1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ZC3HAV1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_020119
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_020119
                                     untagged cDNA clones in CMV expression vector (see all 4): AK055851 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_020119

    UniProtKB/Swiss-Prot: ZCCHV_HUMAN, Q7Z2W4
    Function: Induces an innate immunity to viral infections by preventing the accumulation of viral
    RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs.
    Inhibits alphavirus and filovirus replication (By similarity)

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding IEA--
    GO:0003950 NAD+ ADP-ribosyltransferase activity IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for ZC3HAV1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615 response to virus IEA--
    About this table

    Drugs & Compounds
    for ZC3HAV1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZC3HAV1
    1 Novoseek chemical compound relationship for ZC3HAV1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 67.34 19 10072766 (2), 14604009 (2), 12215647 (2), 16343905 (1) (see all 15)
    About this table


    Transcripts
    for ZC3HAV1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ZC3HAV1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZC3HAV1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024625

                  Sigma-Aldrich siRNA and siRNA Panels for ZC3HAV1  
                         Sigma-Aldrich shRNA for ZC3HAV1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_020119  NM_024625  

    REFSEQ mRNAs for ZC3HAV1 gene (2 alternative transcripts): 

    NM_020119.3   NM_024625.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_020119  NM_024625  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_020119
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_020119
                                     untagged cDNA clones in CMV expression vector (see all 4): AK055851 

    Additional cDNA sequence: 

    AF138863.1 AK023350.1 AK098308.1 AK292811.1 BC002935.1 BC025308.1 BC027462.1 BC033105.1 
    BC038809.1 BC040956.1 BX571742.1 BX647138.1 BX647974.1 

    12 DOTS entries:

    DT.315421  DT.40309997  DT.101973731  DT.100710403  DT.100881520  DT.100750254  DT.121104934  DT.454847 
    DT.91909295  DT.100881524  DT.121104971  DT.121104945 

    24/286 AceView cDNA sequences (see all 286 ):

    CA389596 AA287643 BU860445 AA843414 AI094650 BM794513 AA446181 AI768946 
    AI418435 AI039328 AW055170 AI032678 AI697377 BP870955 BM552559 AI092223 
    AI124768 BU621923 BX504426 BF026337 AA477574 AI383902 BQ129976 BF475435 

    highest scoring ESTs for ZC3HAV1:

    AA704533 AA852983 AI133727 AI635522 BC025308 BC033105 BC040956 BE782209 BM016653 BM541963 

    Unigene Cluster for ZC3HAV1:

    Zinc finger CCCH-type, antiviral 1
    Hs.133512  [show with all ESTs]
    Unigene Representative Sequence: NM_020119


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000242351  

    Expression
    for ZC3HAV1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZC3HAV1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZC3HAV1

    1 / 2 / 3

    11 probe-sets matching ZC3HAV1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    56525_at2, 3 U95-B 1 1.00 1.00 0.97 1.38 N73873 0.80 1.00 0.91 1

    		35682_at2, 3 U95-A 1 1.00 1.00 0.85 0.63 AI133727 0.80 1.00 0.91 1
    69142_at2, 3 U95-E 1 1.00 1.00 0.92 1.01 AI635522 0.80 1.00 0.91 1

    		220104_at2, 3 U133-A 1 1.00 1.00 -- -- NM_020119 0.60 1.00 0.82 1

    		213051_at2, 3 U133-A 1 1.00 1.00 -- -- AI133727 0.80 1.00 0.91 1

    		225634_at2, 3 U133-B 1 1.00 1.00 -- -- BG533558 0.60 1.00 0.82 1

    		220104_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		213051_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		225634_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1563076_x_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1563075_s_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ZC3HAV1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.133512

    Expression variation in blood from EXPOLDB for ZC3HAV1

    Orthologs
    for ZC3HAV1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ZC3HAV1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 ZC3HAV11   -- zinc finger CCCH-type, antiviral 1 98.78(n)
    97.56(a)    		 472529  XM_527904.2  XP_527904.2 
    cow
    (Bos taurus)    		 ZC3HAV11   -- zinc finger CCCH-type, antiviral 1 76.79(n)
    64.46(a)    		 614589  XM_866143.2  XP_871236.2 
    rat
    (Rattus norvegicus)    		 Zc3hav11   -- zinc finger CCCH type, antiviral 1 62.3(n)
    53.96(a)    		 252832  NM_173045.1  NP_766633.1 
    mouse
    (Mus musculus)    		 Zc3hav11, 5 65
    		 zinc finger CCCH type, antiviral 11, 5 70.05(n)1
    61.94(a)1    		 787811  NM_028864.21  NP_083140.11 
     AI0610105  AK0047705  (see all 18)
    chicken
    (Gallus gallus)    		 ZC3HAV11   -- zinc finger CCCH-type, antiviral 1 55.69(n)
    46.55(a)    		 426315  NM_001012938.1  NP_001012956.1 
    About this table        Species with no ortholog for ZC3HAV1

    ENSEMBL Gene Tree for ZC3HAV1

    Paralogs
    for ZC3HAV1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZC3HAV1 gene
    PARP112  PARP122  TIPARP2  

    SNPs/Variants
    for ZC3HAV1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/453 NCBI SNPs in ZC3HAV1 are shown (see all 453 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 143)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs22972411,2
    		A,C,F,H,O138411574(+) TACAGG/CTGGAT 2 Q/H mis113Minor allele frequency- C:0.34EA EU WA NA 2550
    rs22364261,2
    		A,C,F,H,O138414773(+) CTACTC/TTTGGG 2 R/K mis1 ese312Minor allele frequency- T:0.29EU EA WA NA 1054
    rs102713731,2
    		A,C,F,H138380335(+) TGACTA/CCTTCA 1 -- ut318Minor allele frequency- C:0.39EU EA WA NA 774
    rs37350071,2
    		A,C,F,H138383037(-) GTTTAC/TTGAAG 1 T/I mis1 ese313Minor allele frequency- N:0.00EA EU WA NA 2534
    rs30879991,2
    		C,F,H,O138382814(-) TTGCCC/GCAGAC 1 -- ut317Minor allele frequency- G:0.44MN NA EA WA 616
    rs18141701,2
    		A,C,F,H138444689(+) CTTACA/TAGTGT 2 -- ut51 ese37Minor allele frequency- T:0.24NA EU EA WA 556
    --
    rs10445511,2
    		A,C,F,H138380565(-) TTCCCA/GTTTTT 1 -- ut31 ese37Minor allele frequency- G:0.41EU EA WA NA 560
    rs78034901,2
    		A,C,F,H138380901(+) ggtgaT/Cgcttt 1 -- ut31 ese34Minor allele frequency- C:0.50EU EA WA 418
    rs77927921,2
    		A,C,F,H138445419(+) TGGACA/GAACCA 2 -- ng3112Minor allele frequency- T:0.02NA EA EU WA 1056
    rs23543351,2
    		A,C,F,H138382227(+) CTGCAA/GTTACA 1 -- ut314Minor allele frequency- G:0.45MN EU EA 482
    About this table

    HapMap Linkage Disequilibrium images for ZC3HAV1 (up to first 250kb)

    Disorders & Mutations
    for ZC3HAV1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 607312

    2 Novoseek disease relationships for ZC3HAV1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 34.09 1 12914788 (1)
    tumors 10.72 1 12914788 (1)
    About this table

    Medical News
    for ZC3HAV1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ZC3HAV1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/40 PubMed articles for ZC3HAV1 gene (see all 40 ):

    Search for ZC3HAV1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZC3HAV1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 56829 HGNC: 23721 AceView: ZC3HAV1 Ensembl:ENSG00000105939 euGenes: HUgn56829
    ECgene: ZC3HAV1 H-InvDB: ZC3HAV1

    Other Databases showing ZC3HAV1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing ZC3HAV1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for ZC3HAV1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ZC3HAV1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZC3HAV1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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     Predesigned and custom siRNAs for ZC3HAV1 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZC3HAV1 Browse small molecules at Sigma-Aldrich
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     Search Novus for antibodies for ZC3HAV1

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