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Aliases for ZC3HAV1 Gene

Aliases for ZC3HAV1 Gene

  • Zinc Finger CCCH-Type Containing, Antiviral 1 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 13 3 4
  • Zinc Finger CCCH Domain-Containing Protein 2 3 4
  • Zinc Finger Antiviral Protein 2 4
  • ZC3HDC2 3 4
  • ARTD13 3 4
  • ZAP 3 4
  • Zinc Finger CCCH-Type Antiviral Protein 1 3
  • CCCH-Type Zinc Finger Antiviral Protein 2
  • Zinc Finger CCCH-Type, Antiviral 1 3
  • FLB6421 3
  • PARP13 3
  • ZC3H2 3

External Ids for ZC3HAV1 Gene

Previous GeneCards Identifiers for ZC3HAV1 Gene

  • GC07M138142
  • GC07M138185
  • GC07M138378
  • GC07M138728
  • GC07M133038

Summaries for ZC3HAV1 Gene

Entrez Gene Summary for ZC3HAV1 Gene

  • This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZC3HAV1 Gene

ZC3HAV1 (Zinc Finger CCCH-Type Containing, Antiviral 1) is a Protein Coding gene. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. GO annotations related to this gene include poly(A) RNA binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP12.

UniProtKB/Swiss-Prot for ZC3HAV1 Gene

  • Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3-5 exoribonuclease complex exosome to degrade the RNA body from the 3-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

Gene Wiki entry for ZC3HAV1 Gene

Additional gene information for ZC3HAV1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3HAV1 Gene

Genomics for ZC3HAV1 Gene

Regulatory Elements for ZC3HAV1 Gene

Enhancers for ZC3HAV1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H139101 2.1 FANTOM5 Ensembl ENCODE dbSUPER 26 +2.2 2234 11.2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 LUC7L2 UBN2 TTC26 ZC3HAV1 ZC3HAV1L PARP12 RPL17P28
GH07H139117 2 FANTOM5 Ensembl ENCODE dbSUPER 23.8 -9.2 -9231 2.3 HDGF PKNOX1 FOXA2 ARNT SIN3A ZNF766 CBX5 ZNF143 FOS JUNB LUC7L2 ZC3HAV1 UBN2 GC07M139117 TTC26
GH07H139074 1.4 Ensembl ENCODE dbSUPER 21.7 +34.2 34244 1.3 HDAC1 FOXA2 RB1 RAD21 RFX5 ZNF143 ATF7 RUNX3 DEK ZNF654 ZC3HAV1 ZC3HAV1L KIAA1549 RPL17P28
GH07H139090 1.6 Ensembl ENCODE dbSUPER 11.2 +15.8 15778 6.6 HDGF PKNOX1 ARNT ZNF766 CBX5 ZNF143 REST SMARCB1 ZNF592 MEF2D LUC7L2 UBN2 ZC3HAV1 TTC26 RPL17P28
GH07H139100 0.7 ENCODE dbSUPER 15.8 +9.3 9281 0.6 ZNF512 ZBTB33 ZC3HAV1 RPL17P28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC3HAV1 on UCSC Golden Path with GeneCards custom track

Promoters for ZC3HAV1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000218913 1220 3801 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143

Genomic Locations for ZC3HAV1 Gene

Genomic Locations for ZC3HAV1 Gene
chr7:139,043,520-139,109,720
(GRCh38/hg38)
Size:
66,201 bases
Orientation:
Minus strand
chr7:138,728,266-138,794,465
(GRCh37/hg19)

Genomic View for ZC3HAV1 Gene

Genes around ZC3HAV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3HAV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3HAV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3HAV1 Gene

Proteins for ZC3HAV1 Gene

  • Protein details for ZC3HAV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2W4-ZCCHV_HUMAN
    Recommended name:
    Zinc finger CCCH-type antiviral protein 1
    Protein Accession:
    Q7Z2W4
    Secondary Accessions:
    • A4D1R2
    • A4D1S4
    • Q8IW57
    • Q8TAJ3
    • Q96N79
    • Q9H8R9
    • Q9P0Y7

    Protein attributes for ZC3HAV1 Gene

    Size:
    902 amino acids
    Molecular mass:
    101431 Da
    Quaternary structure:
    • Homodimer or homooligomer. Homooligomerization is essential for its antiviral activity. Interacts with EXOSC5 (By similarity). Interacts (via N-terminal domain) with DDX17 in an RNA-independent manner (By similarity). Interacts with EXOSC3, EXOSC7, DCP2 and DCP1A. Interacts with PARN in an RNA-independent manner. Interacts with XRN1 in an RNA-dependent manner. Isoform 2 interacts (via zinc-fingers) with DDX58/RIG-I in an RNA-dependent manner. Interacts (via N-terminal domain) with DHX30 (via N-terminus) in an RNA-independent manner.

    Three dimensional structures from OCA and Proteopedia for ZC3HAV1 Gene

    Alternative splice isoforms for ZC3HAV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3HAV1 Gene

Post-translational modifications for ZC3HAV1 Gene

  • Phosphorylation at Ser-275 is essential for sequential phosphorylation of Ser-271, Ser-267, Ser-263 and Ser-257 by GSK3-beta. Phosphorylation by GSK3-beta enhances its antiviral activity (By similarity).
  • Ubiquitination at isoforms=2, 312, isoforms=2, 4, 5695, and isoforms=4783
  • Modification sites at PhosphoSitePlus

Other Protein References for ZC3HAV1 Gene

No data available for DME Specific Peptides for ZC3HAV1 Gene

Domains & Families for ZC3HAV1 Gene

Gene Families for ZC3HAV1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ZC3HAV1 Gene

Suggested Antigen Peptide Sequences for ZC3HAV1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z2W4

UniProtKB/Swiss-Prot:

ZCCHV_HUMAN :
  • The N-terminal domain is sufficient to bind to viral RNAs and promote their degradation. The second and fourth zinc fingers are involved in binding to specific viral RNAs (PubMed:20451500). Contains a divergent PARP homology ADP-ribosyltransferase domain which lacks the structural requirements for NAD[+] binding. It is therefore inactive (PubMed:25635049).
Domain:
  • The N-terminal domain is sufficient to bind to viral RNAs and promote their degradation. The second and fourth zinc fingers are involved in binding to specific viral RNAs (PubMed:20451500). Contains a divergent PARP homology ADP-ribosyltransferase domain which lacks the structural requirements for NAD[+] binding. It is therefore inactive (PubMed:25635049).
genes like me logo Genes that share domains with ZC3HAV1: view

Function for ZC3HAV1 Gene

Molecular function for ZC3HAV1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Temperature dependence: Thermostable. {ECO:0000269 PubMed:20451500};
UniProtKB/Swiss-Prot Function:
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3-5 exoribonuclease complex exosome to degrade the RNA body from the 3-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses. Isoform 2 is up-regulated by 3-PPP-RNA.

Gene Ontology (GO) - Molecular Function for ZC3HAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 22658674
GO:0003950 NOT NAD+ ADP-ribosyltransferase activity IMP,IEA 25635049
GO:0005515 protein binding IPI 21102435
GO:0045296 cadherin binding IDA 25468996
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3HAV1: view
genes like me logo Genes that share phenotypes with ZC3HAV1: view

Animal Models for ZC3HAV1 Gene

MGI Knock Outs for ZC3HAV1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZC3HAV1 Gene

Localization for ZC3HAV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3HAV1 Gene

Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250}.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3HAV1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
golgi apparatus 2
plasma membrane 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZC3HAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZC3HAV1: view

Pathways & Interactions for ZC3HAV1 Gene

genes like me logo Genes that share pathways with ZC3HAV1: view

Pathways by source for ZC3HAV1 Gene

Gene Ontology (GO) - Biological Process for ZC3HAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009615 response to virus IDA 21876179
GO:0045071 negative regulation of viral genome replication IDA 21876179
GO:0045087 innate immune response IEA --
GO:0051607 defense response to virus IEA --
GO:0061014 positive regulation of mRNA catabolic process IDA 21876179
genes like me logo Genes that share ontologies with ZC3HAV1: view

No data available for SIGNOR curated interactions for ZC3HAV1 Gene

Drugs & Compounds for ZC3HAV1 Gene

(1) Drugs for ZC3HAV1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZC3HAV1: view

Transcripts for ZC3HAV1 Gene

Unigene Clusters for ZC3HAV1 Gene

Zinc finger CCCH-type, antiviral 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3HAV1 Gene

No ASD Table

Relevant External Links for ZC3HAV1 Gene

GeneLoc Exon Structure for
ZC3HAV1
ECgene alternative splicing isoforms for
ZC3HAV1

Expression for ZC3HAV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3HAV1 Gene

mRNA differential expression in normal tissues according to GTEx for ZC3HAV1 Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for ZC3HAV1 Gene

This gene is overexpressed in Lung (40.1) and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC3HAV1 Gene



Protein tissue co-expression partners for ZC3HAV1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC3HAV1 Gene:

ZC3HAV1

SOURCE GeneReport for Unigene cluster for ZC3HAV1 Gene:

Hs.133512

Evidence on tissue expression from TISSUES for ZC3HAV1 Gene

  • Nervous system(4.5)
  • Liver(4.4)
  • Blood(4.3)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with ZC3HAV1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3HAV1 Gene

Orthologs for ZC3HAV1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3HAV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3HAV1 33 34
  • 98.78 (n)
dog
(Canis familiaris)
Mammalia ZC3HAV1 33 34
  • 78.21 (n)
cow
(Bos Taurus)
Mammalia ZC3HAV1 33 34
  • 76.77 (n)
rat
(Rattus norvegicus)
Mammalia Zc3hav1 33
  • 71.06 (n)
mouse
(Mus musculus)
Mammalia Zc3hav1 33 16 34
  • 69.66 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC3HAV1 34
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3HAV1 34
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3HAV1 33 34
  • 56.53 (n)
lizard
(Anolis carolinensis)
Reptilia ZC3HAV1 34
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii parp12b 34
  • 34 (a)
ManyToMany
Species where no ortholog for ZC3HAV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3HAV1 Gene

ENSEMBL:
Gene Tree for ZC3HAV1 (if available)
TreeFam:
Gene Tree for ZC3HAV1 (if available)

Paralogs for ZC3HAV1 Gene

Paralogs for ZC3HAV1 Gene

(1) SIMAP similar genes for ZC3HAV1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZC3HAV1: view

Variants for ZC3HAV1 Gene

Sequence variations from dbSNP and Humsavar for ZC3HAV1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000011294 -- 139,084,707(+) GAAAA(C/G)ATTTG intron-variant
rs1000026527 -- 139,068,442(+) TGCTG(C/T)TTTTC intron-variant
rs1000156805 -- 139,050,496(+) TCGAG(G/T)AGCTA intron-variant
rs1000179461 -- 139,073,797(+) ACAGT(A/G)TTCTT intron-variant, downstream-variant-500B
rs1000260294 -- 139,056,025(+) ACAGA(A/G)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3HAV1 Gene

Variant ID Type Subtype PubMed ID
nsv957595 CNV deletion 24416366
nsv831155 CNV loss 17160897
nsv1147149 CNV deletion 26484159
nsv1076956 CNV deletion 25765185
esv5513 CNV loss 19470904
esv3542508 CNV deletion 23714750
esv3022 CNV loss 18987735
esv2759567 CNV gain 17122850
esv2735229 CNV deletion 23290073
esv2735212 CNV deletion 23290073
esv2494461 CNV deletion 19546169
esv2303577 CNV deletion 18987734
esv1728101 CNV deletion 17803354
esv1644522 CNV insertion 17803354
dgv6640n100 CNV gain 25217958
dgv3677n106 CNV deletion 24896259

Variation tolerance for ZC3HAV1 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3HAV1 Gene

Human Gene Mutation Database (HGMD)
ZC3HAV1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3HAV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3HAV1 Gene

Disorders for ZC3HAV1 Gene

Relevant External Links for ZC3HAV1

Human Genome Epidemiology (HuGE) Navigator
ZC3HAV1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3HAV1

No disorders were found for ZC3HAV1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3HAV1 Gene

Publications for ZC3HAV1 Gene

  1. Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein. (PMID: 25635049) Karlberg T … Schüler H (The Journal of biological chemistry 2015) 2 3 4 60
  2. Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein. (PMID: 18225958) Kerns JA … Malik HS (PLoS genetics 2008) 3 4 22 60
  3. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M … Katoh M (International journal of oncology 2003) 2 3 22 60
  4. Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. (PMID: 12215647) Gao G … Goff SP (Science (New York, N.Y.) 2002) 2 3 22 60
  5. ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses. (PMID: 21102435) Hayakawa S … Takaoka A (Nature immunology 2011) 3 4 60

Products for ZC3HAV1 Gene

Sources for ZC3HAV1 Gene

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