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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZC3HAV1 Gene

protein-coding   GIFtS: 54
GCID: GC07M138728

Zinc Finger CCCH-Type, Antiviral 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger CCCH-Type, Antiviral 11 2     FLB64212 5
ZAP2 3 5      CCCH-Type Zinc Finger Antiviral Protein1
Zinc Finger Antiviral Protein1 3     PARP132
Zinc Finger CCCH Domain-Containing Protein 22 3     ZC3H22
ARTD132 3     Zinc Finger CCCH-Type Antiviral Protein 12
ZC3HDC22 3     FLJ132885
ADP-Ribosyltransferase Diphtheria Toxin-Like 132 3     

External Ids:    HGNC: 237211   Entrez Gene: 568292   Ensembl: ENSG000001059397   OMIM: 6073125   UniProtKB: Q7Z2W43   

Export aliases for ZC3HAV1 gene to outside databases

Previous GC identifers: GC07M138142 GC07M138185 GC07M138378 GC07M133038


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZC3HAV1 Gene:
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of
the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an
innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding
distinct isoforms, are described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZC3HAV1 Gene: 
ZC3HAV1 (zinc finger CCCH-type, antiviral 1) is a protein-coding gene. Diseases associated with ZC3HAV1 include diphtheria, and albinism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and RNA binding. An important paralog of this gene is PARP15.

UniProtKB/Swiss-Prot: ZCCHV_HUMAN, Q7Z2W4
Function: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation
machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA,
recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease
complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through
RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the
5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1
(HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola
virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically
targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more
potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting
in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes
(ISGs)

Gene Wiki entry for ZC3HAV1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZC3HAV1 gene promoter:
         USF1   USF2   LUN-1   USF-1:USF-2   HNF-3beta   Evi-1   c-Rel   USF-1   HSF2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ZC3HAV1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZC3HAV1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3HAV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

ZC3HAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3HAV1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M138728:  view genomic region     (about GC identifiers)

Start:
138,728,266 bp from pter      End:
138,794,465 bp from pter
Size:
66,200 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 138,072,485-138,139,025     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZCCHV_HUMAN, Q7Z2W4 (See protein sequence)
Recommended Name: Zinc finger CCCH-type antiviral protein 1  
Size: 902 amino acids; 101431 Da
Subunit: Homodimer or homooligomer. Homooligomerization is essential for its antiviral activity. Interacts with
EXOSC5 (By similarity). Interacts (via N-terminal domain) with DDX17 in an RNA-independent manner (By
similarity). Interacts with EXOSC3, EXOSC7, DCP2 and DCP1A. Interacts with PARN in an RNA-independent manner.
Interacts with XRN1 in an RNA-dependent manner. Isoform 2 interacts (via zinc-fingers) with DDX58/RIG-I in an
RNA-dependent manner. Interacts (via N-terminal domain) with DHX30 (via N-terminus) in an RNA-independent manner
Subcellular location: Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles
between nucleus and cytoplasm in a XPO1-dependent manner (By similarity)
Subcellular location: Isoform 2: Cytoplasm
1 PDB 3D structure from and Proteopedia for ZC3HAV1:
2X5Y (3D)    
Secondary accessions: A4D1R2 A4D1S4 Q8IW57 Q8TAJ3 Q96N79 Q9H8R9 Q9P0Y7
Alternative splicing: 5 isoforms:  Q7Z2W4-1   Q7Z2W4-2   Q7Z2W4-3   Q7Z2W4-4   Q7Z2W4-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZC3HAV1: NX_Q7Z2W4

Explore proteomics data for ZC3HAV1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-275 is essential for sequential phosphorylation of Ser-271, Ser-267, Ser-263 and Ser-257 by
    GSK3-beta. Phosphorylation by GSK3-beta enhances its antiviral activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z2W4

  • ZC3HAV1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZC3HAV1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_064504.2  NP_078901.3  

    ENSEMBL proteins: 
     ENSP00000242351   ENSP00000418385   ENSP00000420107   ENSP00000419855  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IDA--

    ZC3HAV1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PARP: Poly (ADP-ribose) polymerases
    ZC3H: Zinc fingers, CCCH-type domain containing

    3 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR004170 WWE-dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z2W4

    ProtoNet protein and cluster: Q7Z2W4

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: ZCCHV_HUMAN, Q7Z2W4
    Domain: The N-terminal domain is sufficient to bind to viral RNAs and promote their degradation. The second and
    fourth zinc fingers are involved in binding to specific viral RNAs
    Similarity: Contains 4 C3H1-type zinc fingers
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 WWE domain


    ZC3HAV1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZCCHV_HUMAN, Q7Z2W4
    Function: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation
    machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA,
    recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease
    complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through
    RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the
    5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1
    (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola
    virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically
    targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more
    potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting
    in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes
    (ISGs)
    Biophysicochemical properties: Temperature dependence: Thermostable;
    Induction: By type I interferon (IFN) and viruses. Isoform 2 is up-regulated by 3'-PPP-RNA

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding ----
         
    ZC3HAV1 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3HAV1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/115 Interacting proteins for ZC3HAV1 (Q7Z2W41, 2, 3 ENSP000002423514) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX58O957861, 3, ENSP000003692134EBI-922559,EBI-995350 I2D: score=1 STRING: ENSP00000369213
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IDA--
    GO:0032481positive regulation of type I interferon production IEA--
    GO:0032727positive regulation of interferon-alpha production IDA--
    GO:0032728positive regulation of interferon-beta production IDA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IMP--

    ZC3HAV1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZC3HAV1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZC3HAV1 (ZCCHV)

    1 Novoseek inferred chemical compound relationship for ZC3HAV1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 68.9 22 10072766 (2), 14604009 (2), 12215647 (2), 16343905 (1) (see all 18)

    Search CenterWatch for drugs/clinical trials and news about ZC3HAV1 / ZCCHV

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZC3HAV1 gene (2 alternative transcripts): 
    NM_020119.3  NM_024625.3  

    Unigene Cluster for ZC3HAV1:

    Zinc finger CCCH-type, antiviral 1
    Hs.133512  [show with all ESTs]
    Unigene Representative Sequence: NM_020119
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242351(uc003vun.3) ENST00000464606 ENST00000460845(uc003vuo.3)
    ENST00000471652(uc003vup.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF138863.1 AK023350.1 AK098308.1 AK292811.1 BC002935.1 BC025308.1 BC027462.1 BC033105.1 
    BC038809.1 BC040956.1 BX571742.1 BX647138.1 BX647974.1 

    12 DOTS entries:

    DT.315421  DT.40309997  DT.101973731  DT.100710403  DT.100881520  DT.100750254  DT.121104934  DT.454847 
    DT.100881524  DT.121104971  DT.91909295  DT.121104945 

    24/286 AceView cDNA sequences (see all 286):

    NM_024625 AA258884 BG940047 CA429151 BE219727 BE676658 BQ422731 CN480688 
    AA554321 BC025308 NM_020119 BQ431960 AA830820 BQ184281 AA398467 AA287643 
    AI681491 CA411705 BM552559 AA595633 BQ015024 AI860720 AW131830 BM472731 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZC3HAV1 expression in normal human tissues (normalized intensities)      ZC3HAV1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZC3HAV1 Expression
    About this image


    ZC3HAV1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             neutrophils   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See ZC3HAV1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZC3HAV1

    SOURCE GeneReport for Unigene cluster: Hs.133512
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZC3HAV1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc3hav11 , 5 zinc finger CCCH type, antiviral 11, 5 70.05(n)1
    61.94(a)1
      6 (17.72 cM)5
    787811  NM_028421.11  NP_082697.11 
     383052865 
    chicken
    (Gallus gallus)
    Aves ZC3HAV11 zinc finger CCCH-type, antiviral 1 55.69(n)
    46.55(a)
      426315  NM_001012938.1  NP_001012956.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    ZC3HAV16
    Uncharacterized protein
    34(a)
    26(a)
    possible ortholog
    1 ↔ 1
    5(15157508-15176453)
    5(83356046-83397875)
    zebrafish
    (Danio rerio)
    Actinopterygii parp12b6
    parp12a6
    (see all 3)
    poly (ADP-ribose) polymerase family, member 12a
    (see all 3)
    33(a)
    32(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    4(8704023-8884755)
    18(12287679-12306569)


    ENSEMBL Gene Tree for ZC3HAV1 (if available)
    TreeFam Gene Tree for ZC3HAV1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZC3HAV1 gene
    PARP152  PARP92  PARP112  PARP102  PARP142  PARP122  TIPARP2  
    1 SIMAP similar gene for ZC3HAV1 using alignment to 4 protein entries:     ZCCHV_HUMAN (see all proteins):
    ZC3HAV1L

    ZC3HAV1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1569 SNPs in ZC3HAV1 are shown (see all 1569)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420809041,2
    --133106186(+) ATACTA/GTGAGA 2 -- us2k10--------
    rs1459180491,2
    --133106196(+) ATCCAC/TCTGGG 2 -- us2k10--------
    rs1142083651,2
    C,F--133106207(+) CAACAT/CAGCGA 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1388287151,2
    --133106265(+) TGCCTA/GTAGTC 2 -- us2k10--------
    rs1493132501,2
    --133106276(+) CCAACG/TACTTG 2 -- us2k10--------
    rs1876159821,2
    --133106293(+) TGCGGC/TGGGAG 2 -- us2k10--------
    rs345484871,2
    C--138082792(+) AAAAAAA/-GACTA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs723658991,2
    C--138085383(+) TCTTT-/TC/TTC
            
    TTTTT
    2 -- int1 cds10--------
    rs556518451,2
    C--138085384(+) CTTTT-/CTT/TC
            
    TTTTT
    2 -- int1 cds10--------
    rs711690741,2
    C--138086089(+) CAGGA-/GGATTGCT 1 -- int11Minor allele frequency- GGA:0.00NA 2

    HapMap Linkage Disequilibrium report for ZC3HAV1 (138728266 - 138794465 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for ZC3HAV1 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2494461CNV Deletion19546169
    esv1728101CNV Deletion17803354
    esv3022CNV Deletion18987735
    esv2735212CNV Deletion23290073
    esv2303577CNV Deletion18987734
    esv2735229CNV Deletion23290073
    esv1644522CNV Insertion17803354
    esv274465CNV Insertion20981092
    esv270223CNV Insertion20981092
    nsv831155CNV Loss17160897


    Human Gene Mutation Database (HGMD): ZC3HAV1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ZC3HAV1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607312    OMIM disorders: --

    4 diseases for ZC3HAV1:    About MalaCards
    diphtheria    albinism    multiple sclerosis    leukemia


    ZC3HAV1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ZC3HAV1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 34.7 1 12914788 (1)
    tumors 11.3 1 12914788 (1)

    Human Genome Epidemiology (HuGE) Navigator: ZC3HAV1 (1 document)

    Export disorders for ZC3HAV1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZC3HAV1 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with ZC3HAV1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein. (PubMed id 18225958)1, 2, 9 Kerns J.A....Malik H.S. (2008)
    2. Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. (PubMed id 12215647)1, 3, 9 Gao G....Goff S.P. (2002)
    3. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PubMed id 12851707)1, 3, 9 Katoh M. and Katoh M. (2003)
    4. Zinc-finger antiviral protein inhibits HIV-1 infectio n by selectively targeting multiply spliced viral mRNAs for degradation. (PubMed id 21876179)1, 2 Zhu Y....Gao G. (2011)
    5. ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses. (PubMed id 21102435)1, 2 Hayakawa S....Takaoka A. (2011)
    6. Expression and RNA-binding of human zinc-finger antiv iral protein. (PubMed id 20451500)1, 2 Jeong M.S....Jang S.B. (2010)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56829 HGNC: 23721 AceView: ZC3HAV1 Ensembl:ENSG00000105939 euGenes: HUgn56829
    ECgene: ZC3HAV1 H-InvDB: ZC3HAV1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZC3HAV1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZC3HAV1 gene:
    Search GeneIP for patents involving ZC3HAV1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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