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Aliases for ZC3HAV1 Gene

Aliases for ZC3HAV1 Gene

  • Zinc Finger CCCH-Type, Antiviral 1 2 3
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 13 3 4
  • Zinc Finger CCCH Domain-Containing Protein 2 3 4
  • Zinc Finger Antiviral Protein 2 4
  • ZC3HDC2 3 4
  • ARTD13 3 4
  • ZAP 3 4
  • CCCH-Type Zinc Finger Antiviral Protein 2
  • FLB6421 3
  • PARP13 3
  • ZC3H2 3

External Ids for ZC3HAV1 Gene

Previous GeneCards Identifiers for ZC3HAV1 Gene

  • GC07M138142
  • GC07M138185
  • GC07M138378
  • GC07M138728
  • GC07M133038

Summaries for ZC3HAV1 Gene

Entrez Gene Summary for ZC3HAV1 Gene

  • This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZC3HAV1 Gene

ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for ZC3HAV1 Gene

  • Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3-5 exoribonuclease complex exosome to degrade the RNA body from the 3-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

Gene Wiki entry for ZC3HAV1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3HAV1 Gene

Genomics for ZC3HAV1 Gene

Regulatory Elements for ZC3HAV1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZC3HAV1 Gene

Chromosome:
7
Start:
139,043,520 bp from pter
End:
139,109,720 bp from pter
Size:
66,201 bases
Orientation:
Minus strand

Genomic View for ZC3HAV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZC3HAV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3HAV1 Gene

Proteins for ZC3HAV1 Gene

  • Protein details for ZC3HAV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2W4-ZCCHV_HUMAN
    Recommended name:
    Zinc finger CCCH-type antiviral protein 1
    Protein Accession:
    Q7Z2W4
    Secondary Accessions:
    • A4D1R2
    • A4D1S4
    • Q8IW57
    • Q8TAJ3
    • Q96N79
    • Q9H8R9
    • Q9P0Y7

    Protein attributes for ZC3HAV1 Gene

    Size:
    902 amino acids
    Molecular mass:
    101431 Da
    Quaternary structure:
    • Homodimer or homooligomer. Homooligomerization is essential for its antiviral activity. Interacts with EXOSC5 (By similarity). Interacts (via N-terminal domain) with DDX17 in an RNA-independent manner (By similarity). Interacts with EXOSC3, EXOSC7, DCP2 and DCP1A. Interacts with PARN in an RNA-independent manner. Interacts with XRN1 in an RNA-dependent manner. Isoform 2 interacts (via zinc-fingers) with DDX58/RIG-I in an RNA-dependent manner. Interacts (via N-terminal domain) with DHX30 (via N-terminus) in an RNA-independent manner.

    Three dimensional structures from OCA and Proteopedia for ZC3HAV1 Gene

    Alternative splice isoforms for ZC3HAV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3HAV1 Gene

Proteomics data for ZC3HAV1 Gene at MOPED

Post-translational modifications for ZC3HAV1 Gene

  • Phosphorylation at Ser-275 is essential for sequential phosphorylation of Ser-271, Ser-267, Ser-263 and Ser-257 by GSK3-beta. Phosphorylation by GSK3-beta enhances its antiviral activity (By similarity).
  • Ubiquitination at Lys 12, Lys 695, and Lys 783
  • Modification sites at PhosphoSitePlus

Other Protein References for ZC3HAV1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZC3HAV1

No data available for DME Specific Peptides for ZC3HAV1 Gene

Domains & Families for ZC3HAV1 Gene

Protein Domains for ZC3HAV1 Gene

Suggested Antigen Peptide Sequences for ZC3HAV1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z2W4

UniProtKB/Swiss-Prot:

ZCCHV_HUMAN :
  • The N-terminal domain is sufficient to bind to viral RNAs and promote their degradation. The second and fourth zinc fingers are involved in binding to specific viral RNAs.
  • Contains 4 C3H1-type zinc fingers.
Domain:
  • The N-terminal domain is sufficient to bind to viral RNAs and promote their degradation. The second and fourth zinc fingers are involved in binding to specific viral RNAs.
  • Contains 1 PARP catalytic domain.
  • Contains 1 WWE domain.
Similarity:
  • Contains 4 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZC3HAV1: view

Function for ZC3HAV1 Gene

Molecular function for ZC3HAV1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Temperature dependence: Thermostable. {ECO:0000269 PubMed:20451500};
UniProtKB/Swiss-Prot Function:
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3-5 exoribonuclease complex exosome to degrade the RNA body from the 3-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses. Isoform 2 is up-regulated by 3-PPP-RNA.

Gene Ontology (GO) - Molecular Function for ZC3HAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0005515 protein binding IPI 21102435
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3HAV1: view

Phenotypes for ZC3HAV1 Gene

GenomeRNAi human phenotypes for ZC3HAV1:
genes like me logo Genes that share phenotypes with ZC3HAV1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC3HAV1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3HAV1 Gene

Localization for ZC3HAV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3HAV1 Gene

Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250}.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3HAV1 Gene COMPARTMENTS Subcellular localization image for ZC3HAV1 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3
endosome 2
lysosome 2
vacuole 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ZC3HAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 21102435
GO:0005764 lysosome IEA --
GO:0005770 late endosome IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with ZC3HAV1: view

Pathways & Interactions for ZC3HAV1 Gene

SuperPathways for ZC3HAV1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3HAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0009615 response to virus IDA 21876179
GO:0032481 positive regulation of type I interferon production IEA --
GO:0032727 positive regulation of interferon-alpha production IDA 21102435
GO:0032728 positive regulation of interferon-beta production IDA 21102435
genes like me logo Genes that share ontologies with ZC3HAV1: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3HAV1 Gene

Drugs & Compounds for ZC3HAV1 Gene

(1) Drugs for ZC3HAV1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
genes like me logo Genes that share compounds with ZC3HAV1: view

Transcripts for ZC3HAV1 Gene

Unigene Clusters for ZC3HAV1 Gene

Zinc finger CCCH-type, antiviral 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC3HAV1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3HAV1 Gene

No ASD Table

Relevant External Links for ZC3HAV1 Gene

GeneLoc Exon Structure for
ZC3HAV1
ECgene alternative splicing isoforms for
ZC3HAV1

Expression for ZC3HAV1 Gene

mRNA expression in normal human tissues for ZC3HAV1 Gene

mRNA differential expression in normal tissues according to GTEx for ZC3HAV1 Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for ZC3HAV1 Gene

This gene is overexpressed in Lung (40.1) and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3HAV1 Gene



SOURCE GeneReport for Unigene cluster for ZC3HAV1 Gene Hs.133512

genes like me logo Genes that share expression patterns with ZC3HAV1: view

Protein tissue co-expression partners for ZC3HAV1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZC3HAV1 Gene

Orthologs for ZC3HAV1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3HAV1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZC3HAV1 35
  • 76.77 (n)
  • 64.31 (a)
ZC3HAV1 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3HAV1 35
  • 78.21 (n)
  • 65.14 (a)
ZC3HAV1 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc3hav1 35
  • 69.66 (n)
  • 61.88 (a)
Zc3hav1 16
Zc3hav1 36
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZC3HAV1 35
  • 98.78 (n)
  • 97.56 (a)
ZC3HAV1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3hav1 35
  • 71.06 (n)
  • 61.29 (a)
oppossum
(Monodelphis domestica)
Mammalia ZC3HAV1 36
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3HAV1 36
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3HAV1 35
  • 56.53 (n)
  • 47.25 (a)
ZC3HAV1 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC3HAV1 36
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii parp12b 36
  • 34 (a)
ManyToMany
Species with no ortholog for ZC3HAV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3HAV1 Gene

ENSEMBL:
Gene Tree for ZC3HAV1 (if available)
TreeFam:
Gene Tree for ZC3HAV1 (if available)

Paralogs for ZC3HAV1 Gene

Paralogs for ZC3HAV1 Gene

(1) SIMAP similar genes for ZC3HAV1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZC3HAV1: view

Variants for ZC3HAV1 Gene

Sequence variations from dbSNP and Humsavar for ZC3HAV1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs9338 -- 139,045,984(-) AGATT(G/T)TGGAT utr-variant-3-prime
rs478776 -- 139,045,869(+) TAACT(C/T)TCCCA utr-variant-3-prime
rs486910 -- 139,056,157(+) ATTTG(A/C)TAATC intron-variant
rs562321 -- 139,088,048(+) aaaaa(A/G)aaaaa intron-variant
rs566300 -- 139,045,661(+) catgt(G/T)aggga utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZC3HAV1 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv831155 CNV Loss 17160897
dgv2141e1 CNV Complex 17122850
esv2494461 CNV Deletion 19546169
esv2303577 CNV Deletion 18987734
esv3022 CNV Deletion 18987735
esv5513 CNV Loss 19470904
esv2735229 CNV Deletion 23290073
esv1728101 CNV Deletion 17803354
esv1644522 CNV Insertion 17803354
esv270223 CNV Insertion 20981092
esv274465 CNV Insertion 20981092

Variation tolerance for ZC3HAV1 Gene

Residual Variation Intolerance Score: 84.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3HAV1 Gene

HapMap Linkage Disequilibrium report
ZC3HAV1
Human Gene Mutation Database (HGMD)
ZC3HAV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3HAV1 Gene

Disorders for ZC3HAV1 Gene

Relevant External Links for ZC3HAV1

Human Genome Epidemiology (HuGE) Navigator
ZC3HAV1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3HAV1
genes like me logo Genes that share disorders with ZC3HAV1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3HAV1 Gene

Publications for ZC3HAV1 Gene

  1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 23 67
  2. Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. (PMID: 12215647) Gao G. … Goff S.P. (Science 2002) 2 23 67
  3. Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein. (PMID: 25635049) Karlberg T. … SchA1ler H. (J. Biol. Chem. 2015) 2 67
  4. The Arabidopsis tandem zinc finger protein AtTZF1 traffics between the nucleus and cytoplasmic foci and binds both DNA and RNA. (PMID: 19897605) Pomeranz M.C. … Jang J.C. (Plant Physiol. 2010) 23 67
  5. Transcription factors Elk-1 and SRF are engaged in IL1-dependent regulation of ZC3H12A expression. (PMID: 20137095) Kasza A. … Jura J. (BMC Mol. Biol. 2010) 23 67

Products for ZC3HAV1 Gene

Sources for ZC3HAV1 Gene

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