ZC3H8 Gene
protein-coding GIFtS: 40
GCID: GC02M112973
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zinc finger CCCH-type containing 8(Previous name: zinc finger CCCH-type domain containing 8 ) (Previous symbol: ZC3HDC8)
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Aliases for ZC3H8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger CCCH-Type Containing 81 2 | | ZC3HDC81 2 3 | | Fliz11 2 | | Zinc Finger CCCH-Type Domain Containing 81 2 | | Zinc Finger CCCH Domain-Containing Protein 82 | | Zinc Finger CCCH Type Domain Containing 82 |
Export aliases for ZC3H8 gene to outside databasesPrevious GC identifers: GC02M112690 GC02M105489 |
Summaries for ZC3H8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZC3H8_HUMAN, Q8N5P1Function: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds tothe 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene(By similarity). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocytehomeostasis
|
Genomic Views for ZC3H8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZC3H8 gene promoter: AREB6 Spz1 GATA-3 RREB-1 GATA-2 GATA-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZC3H8
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H8 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13ZC3H8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M112973: view genomic region
(about GC identifiers)
Start:
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112,973,254 bp from pter |
End:
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113,012,713 bp from pter |
Size:
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39,460 bases |
Orientation:
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minus strand |
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Proteins for ZC3H8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZC3H8_HUMAN, Q8N5P1 (See
protein sequence)Recommended Name: Zinc finger CCCH domain-containing protein 8 Size: 291 amino acids; 33576 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAH32001.1; Type=Frameshift; Positions=291;
Secondary accessions: Q9BZ75Explore the universe of human proteins at neXtProt for ZC3H8: NX_Q8N5P1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N5P1 ZC3H8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115883.2 ENSEMBL proteins: ENSP00000386488 ENSP00000272570 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
ISS | -- |
ZC3H8 for ontologies About GeneDecksing
ZC3H8 Antibody Products: Assay Products for ZC3H8: |
Protein
Domains / Families for ZC3H8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZC3H8 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N5P1ProtoNet protein and cluster: Q8N5P1 1 Blocks protein family: IPB000571 Zn-finger
UniProtKB/Swiss-Prot: ZC3H8_HUMAN, Q8N5P1Domain: The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repressionSimilarity: Contains 3 C3H1-type zinc fingers |
Function for ZC3H8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZC3H8_HUMAN, Q8N5P1Function: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds tothe 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene(By similarity). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocytehomeostasis
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H8 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H8 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZC3H8 (NM_032494) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H8 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZC3H8 for ontologies About GeneDecksing
|
Pathways & Interactions for ZC3H8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3H8
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
ZC3H8 for ontologies About GeneDecksing
|
Drugs & Compounds for ZC3H8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZC3H8 Search CenterWatch for drugs/clinical trials and news about ZC3H8 
|
Transcripts for ZC3H8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZC3H8 gene: NM_032494.2 Unigene Cluster for ZC3H8: Zinc finger CCCH-type containing 8 Hs.418416 [show with all ESTs]Unigene Representative Sequence: BC0320017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409573(uc021vmw.1) ENST00000476902 ENST00000474234 ENST00000466259 ENST00000464305 ENST00000495264 ENST00000272570
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H8 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H8 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZC3H8 (NM_032494) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZC3H8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H8  |
Additional cDNA sequence: AF334161.1 AK315329.1 BC032001.1 5 DOTS entries: DT.407615 DT.95264603 DT.95264604 DT.100766708 DT.91742439 24/86 AceView cDNA sequences (see all 86): CB133959 AA213370 AA196768 AA316412 BI907571 AA489020 BU677501 AI631540 BX119500 CR590012 AI288561 AA665159 AI288563 AI160873 AI640199 BC032001 AI123257 AA889221 AW187997 BG163718 BI770178 AL530577 AW338214 CD108370 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H8 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZC3H8
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Expression for ZC3H8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZC3H8 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See ZC3H8 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZC3H8
SOURCE GeneReport for Unigene cluster: Hs.418416 SABiosciences Custom PCR Arrays for ZC3H8
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZC3H8 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZC3H8 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC3H8 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC3H8 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H8 |
Orthologs for ZC3H8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZC3H8 gene from 5/14 species (see all 14) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
zebrafish (Danio rerio) |
Actinopterygii |
CABZ01077452.16 |
-- |
11(a) |
1 → many |
13(48803008-48816493) |
fruit fly (Drosophila melanogaster) |
Insecta |
su(s)6 |
suppressor of sable |
3(a) |
1 → many |
X(529920-537793) |
worm (Caenorhabditis elegans) |
Secernentea |
T26A8.46 |
Protein T26A8.4 |
10(a) |
1 → many |
IV(8428948-8431482) |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
emb17896 |
zinc finger CCCH domain-containing protein 65 |
6(a) |
1 → many |
5(23027892-23030565) |
rice (Oryza sativa) |
Liliopsida |
-- |
zinc finger C-x8-C-x5-C-x3-H type family protein, ... |
7(a) |
1 → many |
1(21972642-21979437) |
ENSEMBL Gene Tree for ZC3H8 (if available) TreeFam Gene Tree for ZC3H8 (if available)  |
Paralogs for ZC3H8 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZC3H8 gene
- ZC3H42 ZC3H62
2 SIMAP similar genes for ZC3H8 using alignment to 1 protein entry: ZC3H8_HUMAN:LOC84524 ZC3H4
ZC3H8 for paralogs About GeneDecksing
|
Genomic Variants for ZC3H8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZC3H8 (112973254 - 113012713 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZC3H8: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC3H8 |
|
Disorders
/ Diseases for ZC3H8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications for ZC3H8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZC3H8 gene integrated from 9 sources: (articles sorted by number of sources associating them with ZC3H8) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1. (PubMed id 12077251)1, 2 Hwang E.S.... Ho I.-C. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Regulation of thymocyte homeostasis by Fliz1. (PubMed id 12153508)1, 2 Hwang E.S. and Ho I.-C. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for ZC3H8 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZC3H8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZC3H8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZC3H8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZC3H8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZC3H8 gene: Search GeneIP for patents involving ZC3H8
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZC3H8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZC3H8 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC3H8 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H8 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZC3H8 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC3H8 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC3H8 |
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| | | Search Tocris compounds for ZC3H8 |
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 | | ZC3H8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H8 |
|  |  |  | | | ThermoFisher Antibody for ZC3H8 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H8 |
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