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Aliases for ZC3H8 Gene

Aliases for ZC3H8 Gene

  • Zinc Finger CCCH-Type Containing 8 2 3
  • Zinc Finger CCCH-Type Domain Containing 8 2 3
  • ZC3HDC8 3 4
  • Zinc Finger CCCH Domain-Containing Protein 8 3
  • Zinc Finger CCCH Type Domain Containing 8 3
  • Fliz1 3

External Ids for ZC3H8 Gene

Previous Symbols for ZC3H8 Gene

  • ZC3HDC8

Summaries for ZC3H8 Gene

GeneCards Summary for ZC3H8 Gene

ZC3H8 (Zinc Finger CCCH-Type Containing 8) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZC3H4.

UniProtKB/Swiss-Prot for ZC3H8 Gene

  • Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5-AGGTCTC-3 sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H8 Gene

Genomics for ZC3H8 Gene

Genomic Location for ZC3H8 Gene

Start:
112,211,525 bp from pter
End:
112,255,136 bp from pter
Size:
43,612 bases
Orientation:
Minus strand

Genomic View for ZC3H8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZC3H8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H8 Gene

Regulatory Elements for ZC3H8 Gene

Proteins for ZC3H8 Gene

  • Protein details for ZC3H8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5P1-ZC3H8_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 8
    Protein Accession:
    Q8N5P1
    Secondary Accessions:
    • Q9BZ75

    Protein attributes for ZC3H8 Gene

    Size:
    291 amino acids
    Molecular mass:
    33576 Da
    Quaternary structure:
    • Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain).
    SequenceCaution:
    • Sequence=AAH32001.1; Type=Frameshift; Positions=291; Evidence={ECO:0000305};

neXtProt entry for ZC3H8 Gene

Proteomics data for ZC3H8 Gene at MOPED

Post-translational modifications for ZC3H8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC3H8 Gene

Domains for ZC3H8 Gene

Gene Families for ZC3H8 Gene

HGNC:
  • ZC3H :Zinc fingers, CCCH-type domain containing

Protein Domains for ZC3H8 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ZC3H8_HUMAN
Domain:
  • The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repression.:
    • Q8N5P1
Similarity:
  • Contains 3 C3H1-type zinc fingers.:
    • Q8N5P1
genes like me logo Genes that share domains with ZC3H8: view

Function for ZC3H8 Gene

Molecular function for ZC3H8 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5-AGGTCTC-3 sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

Gene Ontology (GO) - Molecular Function for ZC3H8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IMP 12153508
GO:0005515 protein binding IPI 23932780
GO:0043565 sequence-specific DNA binding ISS --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H8: view

miRNA for ZC3H8 Gene

miRTarBase miRNAs that target ZC3H8

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZC3H8 Gene

Localization for ZC3H8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H8 Gene

Nucleus. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H8 Gene COMPARTMENTS Subcellular localization image for ZC3H8 gene
Compartment Confidence
nucleus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZC3H8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0008023 transcription elongation factor complex IDA 23932780
GO:0015030 Cajal body IDA 23932780
GO:0035327 transcriptionally active chromatin IDA 23932780
GO:0035363 histone locus body IDA 23932780
genes like me logo Genes that share ontologies with ZC3H8: view

Pathways for ZC3H8 Gene

SuperPathways for ZC3H8 Gene

No Data Available

Interacting Proteins for ZC3H8 Gene

Gene Ontology (GO) - Biological Process for ZC3H8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0033085 negative regulation of T cell differentiation in thymus IMP 12153508
GO:0042795 snRNA transcription from RNA polymerase II promoter IMP 23932780
GO:0042796 snRNA transcription from RNA polymerase III promoter IMP 23932780
GO:0043029 T cell homeostasis IMP 12153508
genes like me logo Genes that share ontologies with ZC3H8: view

No data available for Pathways by source for ZC3H8 Gene

Transcripts for ZC3H8 Gene

Unigene Clusters for ZC3H8 Gene

Zinc finger CCCH-type containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - -

Relevant External Links for ZC3H8 Gene

GeneLoc Exon Structure for
ZC3H8
ECgene alternative splicing isoforms for
ZC3H8

Expression for ZC3H8 Gene

mRNA expression in normal human tissues for ZC3H8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3H8 Gene

SOURCE GeneReport for Unigene cluster for ZC3H8 Gene Hs.418416

genes like me logo Genes that share expressions with ZC3H8: view

Orthologs for ZC3H8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H8 36
  • 99.43 (n)
  • 99.31 (a)
ZC3H8 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZC3H8 36
  • 86.92 (n)
  • 82.29 (a)
ZC3H8 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H8 36
  • 89.85 (n)
  • 88.93 (a)
ZC3H8 37
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc3h8 36
  • 84.31 (n)
  • 79.38 (a)
Zc3h8 16
Zc3h8 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H8 37
  • 25 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3h8 36
  • 82.36 (n)
  • 77.32 (a)
chicken
(Gallus gallus)
Aves ZC3H6 37
  • 11 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 12 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZC3H8 37
  • 10 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta su(s) 37
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T26A8.4 37
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4406 37
  • 2 (a)
OneToMany
Species with no ortholog for ZC3H8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZC3H8 Gene

ENSEMBL:
Gene Tree for ZC3H8 (if available)
TreeFam:
Gene Tree for ZC3H8 (if available)

Paralogs for ZC3H8 Gene

Paralogs for ZC3H8 Gene

Selected SIMAP similar genes for ZC3H8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZC3H8: view

Variants for ZC3H8 Gene

Sequence variations from dbSNP and Humsavar for ZC3H8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1343666 -- 112,229,378(-) AACTG(C/G)TAGAA intron-variant
rs2254860 -- 112,238,233(-) TTTTC(C/T)TTGCA intron-variant
rs2312458 -- 112,248,847(-) TCTTA(A/G)TTAAT intron-variant
rs2312459 -- 112,243,752(-) GACAA(C/T)AAATA intron-variant
rs2872044 -- 112,239,669(-) aggca(A/G)aggtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H8 Gene

Variant ID Type Subtype PubMed ID
nsv521956 CNV Loss 19592680
nsv874863 CNV Loss 21882294
dgv4278n71 CNV Gain 21882294
nsv874866 CNV Loss 21882294
nsv874867 CNV Loss 21882294
esv274158 CNV Insertion 20981092
esv269711 CNV Insertion 20981092

Relevant External Links for ZC3H8 Gene

HapMap Linkage Disequilibrium report
ZC3H8

Disorders for ZC3H8 Gene

No disorders were found for ZC3H8 Gene.

No data available for UniProtKB/Swiss-Prot for ZC3H8 Gene

Publications for ZC3H8 Gene

  1. Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1. (PMID: 12077251) Hwang E.S. … Ho I.-C. (J. Immunol. 2002) 3 4
  2. Regulation of thymocyte homeostasis by Fliz1. (PMID: 12153508) Hwang E.S. … Ho I.-C. (Immunology 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. (PMID: 23932780) Hu D. … Shilatifard A. (Mol. Cell 2013) 3 4

Products for ZC3H8 Gene

Sources for ZC3H8 Gene

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