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ZC3H8 Gene

protein-coding   GIFtS: 45
GCID: GC02M112973

Zinc Finger CCCH-Type Containing 8

(Previous name: zinc finger CCCH-type domain containing 8)
(Previous symbol: ZC3HDC8)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger CCCH-Type Containing 81 2
ZC3HDC81 2 3
Zinc Finger CCCH-Type Domain Containing 81 2
Fliz12
Zinc Finger CCCH Domain-Containing Protein 82
Zinc Finger CCCH Type Domain Containing 82

External Ids:    HGNC: 309411   Entrez Gene: 845242   Ensembl: ENSG000001441617   UniProtKB: Q8N5P13   

Export aliases for ZC3H8 gene to outside databases

Previous GC identifers: GC02M112690 GC02M105489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZC3H8 Gene:
ZC3H8 (zinc finger CCCH-type containing 8) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZC3H4.

UniProtKB/Swiss-Prot: ZC3H8_HUMAN, Q8N5P1
Function: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that
binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of
the GATA3 gene (By similarity). Induces thymocyte apoptosis when overexpressed, which may indicate a role in
regulation of thymocyte homeostasis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZC3H8 gene promoter:
         AREB6   Spz1   GATA-3   RREB-1   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC3H8 promoter sequence
   Search Chromatin IP Primers for ZC3H8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZC3H8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q13

ZC3H8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3H8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M112973:  view genomic region     (about GC identifiers)

Start:
112,969,102 bp from pter      End:
113,012,713 bp from pter
Size:
43,612 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZC3H8_HUMAN, Q8N5P1 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 8  
Size: 291 amino acids; 33576 Da
Sequence caution: Sequence=AAH32001.1; Type=Frameshift; Positions=291;
Secondary accessions: Q9BZ75

Explore the universe of human proteins at neXtProt for ZC3H8: NX_Q8N5P1

Explore proteomics data for ZC3H8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZC3H8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115883.2  
    ENSEMBL proteins: 
     ENSP00000386488   ENSP00000272570  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC3H: Zinc fingers, CCCH-type domain containing

    1 InterPro protein domain:
     IPR000571 Znf_CCCH

    Graphical View of Domain Structure for InterPro Entry Q8N5P1

    ProtoNet protein and cluster: Q8N5P1

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: ZC3H8_HUMAN, Q8N5P1
    Domain: The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional
    repression
    Similarity: Contains 3 C3H1-type zinc fingers


    Find genes that share domains with ZC3H8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZC3H8_HUMAN, Q8N5P1
    Function: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that
    binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of
    the GATA3 gene (By similarity). Induces thymocyte apoptosis when overexpressed, which may indicate a role in
    regulation of thymocyte homeostasis

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IMP12153508
    GO:0003723RNA binding ----
    GO:0043565sequence-specific DNA binding ISS--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZC3H8           About GenesLikeMe


    Animal Models:
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    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZC3H8_HUMAN, Q8N5P1: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    Find genes that share ontologies with ZC3H8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZC3H8
    Interactions:

        Search GeneGlobe Interaction Network for ZC3H8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZC3H8 (ENSP000003864884) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF1ENSP000003393534STRING: ENSP00000339353
    CPSF2ENSP000002988754STRING: ENSP00000298875
    RBBP6ENSP000003178724STRING: ENSP00000317872
    SYMPKENSP000002459344STRING: ENSP00000245934
    WDR82ENSP000002964904STRING: ENSP00000296490
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006915apoptotic process IEA--
    GO:0033085negative regulation of T cell differentiation in thymus IMP12153508
    GO:0043029T cell homeostasis IMP12153508
    GO:0045892negative regulation of transcription, DNA-templated ISS--

    Find genes that share ontologies with ZC3H8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZC3H8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZC3H8 gene: 
    NM_032494.2  

    Unigene Cluster for ZC3H8:

    Zinc finger CCCH-type containing 8
    Hs.418416  [show with all ESTs]
    Unigene Representative Sequence: BC032001
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409573(uc021vmw.1) ENST00000476902 ENST00000474234 ENST00000466259
    ENST00000464305 ENST00000495264 ENST00000272570
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      QuantiTect SYBR Green Assays in human, mouse, rat ZC3H8
      QuantiFast Probe-based Assays in human, mouse, rat ZC3H8

    Additional mRNA sequence: 

    AF334161.1 AK315329.1 BC032001.1 

    5 DOTS entries:

    DT.407615  DT.95264603  DT.95264604  DT.100766708  DT.91742439 

    Selected AceView cDNA sequences (see all 86):

    AA196768 AA316412 AI288561 AI288563 AA213370 AA665159 BX119500 BU677501 
    BI907571 AA489020 CB133959 AI631540 CR590012 AI160873 AI123257 BG773518 
    AI472269 AA829479 BQ018359 AI168475 BX500863 BI770178 BC032001 AA912507 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H8    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                                
    SP2:                                      -     -                                                   
    SP3:                    -     -           -     -                                                   
    SP4:                    -     -           -                                                         
    SP5:                    -     -                                                                     


    ECgene alternative splicing isoforms for ZC3H8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZC3H8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZC3H8 Expression
    About this image


    ZC3H8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
    ZC3H8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZC3H8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.418416
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZC3H8 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc3h81 , 5 zinc finger CCCH type containing 81, 5 84.31(n)1
    79.38(a)1
      2 (62.63 cM)5
    574321  NM_020594.21  NP_065619.21 
     1289262685 
    chicken
    (Gallus gallus)
    Aves ZC3H66
    Gallus gallus zinc finger CCCH-type containing 6 (...
    11(a)
    1 → many
    3(3165725-3195099)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    12(a)
    1 → many
    GL343437.1(103413-128333)
    zebrafish
    (Danio rerio)
    Actinopterygii ZC3H86
    zinc finger CCCH-type containing 8
    10(a)
    1 → many
    13(48803008-48816493) ENSDARG00000075165
    fruit fly
    (Drosophila melanogaster)
    Insecta su(s)6
    suppressor of sable
    4(a)
    1 → many
    X(529920-537793)
    worm
    (Caenorhabditis elegans)
    Secernentea T26A8.46
    Protein T26A8.4 (T26A8.4) mRNA, complete cds
    7(a)
    1 → many
    IV(8428961-8431493) WBGene00020827


    ENSEMBL Gene Tree for ZC3H8 (if available)
    TreeFam Gene Tree for ZC3H8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZC3H8 gene
    ZC3H42  ZC3H62  
    2 SIMAP similar genes for ZC3H8 using alignment to 1 protein entry:     ZC3H8_HUMAN:
    LOC84524    ZC3H4

    Find genes that share paralogs with ZC3H8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZC3H8 (see all 656)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844386751,2
    --112973021(+) TGGAGC/TATATG 1 -- int10--------
    rs778198121,2
    C,F--112973078(+) CTTTGA/TTTCCT 1 -- int11Minor allele frequency- T:0.13NA 120
    rs1431007601,2
    --112973185(+) ACAATA/TTAATG 1 -- int10--------
    rs1507893361,2
    C--112973339(+) AAAGTA/TTGTAA 1 -- int10--------
    rs1391589421,2
    C--112973341(+) AGTTTA/GTAACT 1 -- int10--------
    rs1881324431,2
    --112973350(+) CTCACA/GCAAGT 1 -- int10--------
    rs1926579251,2
    --112973414(+) TTTAAC/TAACAG 1 -- int10--------
    rs1849989561,2
    --112973419(+) CAACAA/GAAAAG 1 -- int10--------
    rs1441123701,2
    C--112973484(+) TATAAC/TAGTAA 1 -- ut310--------
    rs1889338251,2
    --112973523(+) GAAACA/TGGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZC3H8 (112969102 - 113012713 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZC3H8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274158CNV Insertion20981092
    esv269711CNV Insertion20981092
    nsv874867CNV Loss21882294
    nsv874866CNV Loss21882294
    nsv521956CNV Loss19592680
    nsv874863CNV Loss21882294
    dgv4278n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZC3H8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ZC3H8 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZC3H8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1. (PubMed id 12077251)1, 2 Hwang E.S.... Ho I.-C. (J. Immunol. 2002)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Regulation of thymocyte homeostasis by Fliz1. (PubMed id 12153508)1, 2 Hwang E.S. and Ho I.-C. (Immunology 2002)
    5. A bead-based approach for large-scale identification of in vitro kinase substrates. (PubMed id 22113938)1 Zhang M....Zou H. (Proteomics 2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84524 HGNC: 30941 AceView: ZC3HDC8 Ensembl:ENSG00000144161 euGenes: HUgn84524
    ECgene: ZC3H8 H-InvDB: ZC3H8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZC3H8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZC3H8 gene:
    Search GeneIP for patents involving ZC3H8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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