Aliases for ZC3H8 Gene
External Ids for ZC3H8 Gene
Previous HGNC Symbols for ZC3H8 Gene
Previous GeneCards Identifiers for ZC3H8 Gene
GeneCards Summary for ZC3H8 Gene
ZC3H8 (Zinc Finger CCCH-Type Containing 8) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include poly(A) RNA binding and sequence-specific DNA binding. An important paralog of this gene is ZC3H4.
UniProtKB/Swiss-Prot for ZC3H8 Gene
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5-AGGTCTC-3 sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.