Aliases for ZC3H8 Gene
External Ids for ZC3H8 Gene
Previous Symbols for ZC3H8 Gene
GeneCards Summary for ZC3H8 Gene
ZC3H8 (Zinc Finger CCCH-Type Containing 8) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZC3H4.
UniProtKB/Swiss-Prot for ZC3H8 Gene
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5-AGGTCTC-3 sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.