ZC3H7B Gene
protein-coding GIFtS: 48
GCID: GC22P041697
|
|
zinc finger CCCH-type containing 7B
| |
Aliases
for ZC3H7B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger CCCH-Type Containing 7B1 2 | | FLJ137871 | | RoXaN1 2 3 | | Rotavirus 'X' Associated Non-Structural Protein2 | | KIAA10311 3 | | Rotavirus X Protein Associated With NSP32 | | Rotavirus 'X'-Associated Non-Structural Protein2 3 | | Ubiquitous Tetratricopeptide Containing Protein RoXaN2 | | DKFZp434K09201 | | Zinc Finger CCCH Domain-Containing Protein 7B2 |
Export aliases for ZC3H7B gene to outside databasesPrevious GC identifers: GC22P040023 GC22P024664 |
Summaries
for ZC3H7B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZC3H7B:
This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts withthe rotavirus non-structural protein NSP3. (provided by RefSeq, Jul 2008)
Gene Wiki entry for ZC3H7B (Roxan)
|
Genomic Views
for ZC3H7B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZC3H7B gene promoter:
AhR CREB AP-1 deltaCREB ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZC3H7B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H7B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2ZC3H7B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P041697: view genomic region
(about GC identifiers)
Start:
|
41,697,526 bp from pter |
End:
|
41,756,151 bp from pter |
Size:
|
58,626 bases |
Orientation:
|
plus strand |
|
Proteins
for ZC3H7B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: Z3H7B_HUMAN, Q9UGR2 (See
protein sequence)Recommended Name: Zinc finger CCCH domain-containing protein 7B Size: 993 amino acids; 111578 Da
Subunit: Interacts (via LD motif) with rotavirus A NSP3 (via the coiled-coil region)
Subcellular location: Nucleus. Note=Nuclear localization seems to be depleted upon rotavirus A infection
Secondary accessions: A7YY88 B2RCA4 Q5TFX9 Q8TBT9 Q9H8B6 Q9UGQ9 Q9UGR0 Q9UGR1 Q9UK03 Q9UPW9Alternative splicing: 2 isoforms: Q9UGR2-1 Q9UGR2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZC3H7B: NX_Q9UGR2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UGR2
ZC3H7B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060060.3
ENSEMBL proteins: ENSP00000345793 ENSP00000263243
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZC3H7B for ontologies About GeneDecksing
ZC3H7B Antibody Products:
Assay Products for ZC3H7B: |
Protein
Domains /
Families
for ZC3H7B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZC3H7B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UGR2ProtoNet protein and cluster: Q9UGR2 1 Blocks protein family: IPB000571 Zn-finger
UniProtKB/Swiss-Prot: Z3H7B_HUMAN, Q9UGR2Similarity: Contains 1 C2H2-type zinc fingerSimilarity: Contains 4 C3H1-type zinc fingersSimilarity: Contains 3 TPR repeats |
Function
for ZC3H7B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H7B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H7B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H7B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZC3H7B for ontologies About GeneDecksing
|
Pathways & Interactions
for ZC3H7B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3H7B
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/6 Interacting proteins for ZC3H7B (Q9UGR21, 2, 3 ENSP000003457934) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019048 | virus-host interaction |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
-- | -- |
ZC3H7B for ontologies About GeneDecksing
|
Drugs & Compounds
for ZC3H7B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZC3H7B
Search CenterWatch for drugs/clinical trials and news about ZC3H7B / Z3H7B
|
Transcripts
for ZC3H7B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZC3H7B gene: NM_017590.5 Unigene Cluster for ZC3H7B: Zinc finger CCCH-type containing 7B Hs.592188 [show with all ESTs]Unigene Representative Sequence: BC1525583 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000352645(uc003azw.3) ENST00000486331(uc003azv.1) ENST00000351589
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H7B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H7B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AB028954.1 AF188530.1 AK021658.1 AK130876.1 AK225891.1 AK315009.1 AL136802.1 BC024313.2 BC047002.1 BC056860.1 BC098378.1 BC127840.1 BC152558.1 15 DOTS entries: DT.309578 DT.97793124 DT.120653885 DT.120653836 DT.100739744 DT.91749318 DT.95191635 DT.97842493 DT.40286943 DT.75108937 DT.120653844 DT.120653886 DT.95077466 DT.91749335 DT.95139385 24/184 AceView cDNA sequences (see all 184): AI732128 AI589865 BE674939 AI821160 BM762209 AI765772 BU506783 AI028132 AW499978 AW194323 CF995164 AW572280 BM712375 AA935554 NM_017590 AA737525 BM478968 AI657066 H55547 BU624556 CB988128 BC047002 BE855831 BF436335
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7B About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for ZC3H7B
|
Expression
for ZC3H7B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZC3H7B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGCGGGGT
About this image
See ZC3H7B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZC3H7B
SOURCE GeneReport for Unigene cluster: Hs.592188
SABiosciences Custom PCR Arrays for ZC3H7B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZC3H7B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H7B |
Orthologs
for ZC3H7B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZC3H7B gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for ZC3H7B (if available)
TreeFam Gene Tree for ZC3H7B (if available) |
Paralogs
for ZC3H7B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZC3H7B gene
- ZC3H7A2
1 SIMAP similar gene for ZC3H7B using alignment to 2 protein entries: Z3H7B_HUMAN (see all proteins):ZC3H7A
ZC3H7B for paralogs About GeneDecksing
|
Genomic Variants
for ZC3H7B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZC3H7B (41697526 - 41756151 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for ZC3H7B
7 CNVs: 5188 50868 50867 36032 9849 50866 36033 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC3H7B |
|
Disorders
/ Diseases
for ZC3H7B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZC3H7B for disorders About GeneDecksing
1  disease for ZC3H7B: About MalaCardsataxia
Human Genome Epidemiology (HuGE) Navigator: ZC3H7B (1 document)
Export disorders for ZC3H7B gene to outside databases
|
Publications
for ZC3H7B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZC3H7B gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with ZC3H7B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
- Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN. (PubMed id 18799579)1, 2 Harb M.... Poncet D. (2008)
- RoXaN, a novel cellular protein containing TPR, LD, and zinc finger motifs, forms a ternary complex with eukaryotic initiation factor 4G and rotavirus NSP3. (PubMed id 15047801)1, 2 Vitour D.... Poncet D. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 3 Wiemann S.... Poustka A. (2001)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for ZC3H7B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZC3H7B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZC3H7B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZC3H7B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZC3H7B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZC3H7B gene:
Search GeneIP for patents involving ZC3H7B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZC3H7B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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