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Aliases for ZC3H7B Gene

Aliases for ZC3H7B Gene

  • Zinc Finger CCCH-Type Containing 7B 2 3 5
  • Rotavirus X-Associated Non-Structural Protein 3 4
  • RoXaN 3 4
  • Ubiquitous Tetratricopeptide Containing Protein RoXaN 3
  • Rotavirus X Associated Non-Structural Protein 3
  • Rotavirus X Protein Associated With NSP3 3
  • KIAA1031 4

External Ids for ZC3H7B Gene

Previous GeneCards Identifiers for ZC3H7B Gene

  • GC22P040023
  • GC22P041697
  • GC22P024664

Summaries for ZC3H7B Gene

Entrez Gene Summary for ZC3H7B Gene

  • This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZC3H7B Gene

ZC3H7B (Zinc Finger CCCH-Type Containing 7B) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is ZC3H7A.

Gene Wiki entry for ZC3H7B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H7B Gene

Genomics for ZC3H7B Gene

Regulatory Elements for ZC3H7B Gene

Promoters for ZC3H7B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZC3H7B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC3H7B Gene

Chromosome:
22
Start:
41,301,503 bp from pter
End:
41,360,147 bp from pter
Size:
58,645 bases
Orientation:
Plus strand

Genomic View for ZC3H7B Gene

Genes around ZC3H7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H7B Gene

Proteins for ZC3H7B Gene

  • Protein details for ZC3H7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGR2-Z3H7B_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 7B
    Protein Accession:
    Q9UGR2
    Secondary Accessions:
    • A7YY88
    • B2RCA4
    • Q5TFX9
    • Q8TBT9
    • Q9H8B6
    • Q9UGQ9
    • Q9UGR0
    • Q9UGR1
    • Q9UK03
    • Q9UPW9

    Protein attributes for ZC3H7B Gene

    Size:
    993 amino acids
    Molecular mass:
    111578 Da
    Quaternary structure:
    • Interacts (via LD motif) with rotavirus A NSP3 (via the coiled-coil region).

    Alternative splice isoforms for ZC3H7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H7B Gene

Proteomics data for ZC3H7B Gene at MOPED

Post-translational modifications for ZC3H7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H7B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZC3H7B Gene

Domains & Families for ZC3H7B Gene

Suggested Antigen Peptide Sequences for ZC3H7B Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGR2

UniProtKB/Swiss-Prot:

Z3H7B_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
  • Contains 4 C3H1-type zinc fingers.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with ZC3H7B: view

Function for ZC3H7B Gene

Gene Ontology (GO) - Molecular Function for ZC3H7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZC3H7B: view

Phenotypes for ZC3H7B Gene

genes like me logo Genes that share phenotypes with ZC3H7B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H7B Gene

Localization for ZC3H7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H7B Gene

Nucleus. Note=Nuclear localization seems to be depleted upon rotavirus A infection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H7B Gene COMPARTMENTS Subcellular localization image for ZC3H7B gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ZC3H7B Gene

Pathways & Interactions for ZC3H7B Gene

SuperPathways for ZC3H7B Gene

No Data Available

Interacting Proteins for ZC3H7B Gene

Gene Ontology (GO) - Biological Process for ZC3H7B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZC3H7B Gene

Drugs & Compounds for ZC3H7B Gene

No Compound Related Data Available

Transcripts for ZC3H7B Gene

mRNA/cDNA for ZC3H7B Gene

Unigene Clusters for ZC3H7B Gene

Zinc finger CCCH-type containing 7B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2:
SP3: -
SP4: -
SP5:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ZC3H7B Gene

GeneLoc Exon Structure for
ZC3H7B
ECgene alternative splicing isoforms for
ZC3H7B

Expression for ZC3H7B Gene

mRNA expression in normal human tissues for ZC3H7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H7B Gene

This gene is overexpressed in Lung (13.0) and Fetal Brain (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZC3H7B Gene



SOURCE GeneReport for Unigene cluster for ZC3H7B Gene Hs.592188

genes like me logo Genes that share expression patterns with ZC3H7B: view

Protein tissue co-expression partners for ZC3H7B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H7B Gene

Orthologs for ZC3H7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H7B 35
  • 98.33 (n)
  • 98.06 (a)
ZC3H7B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZC3H7B 36
  • 96 (a)
OneToOne
ZC3H7B 35
  • 91.92 (n)
  • 96.46 (a)
dog
(Canis familiaris)
Mammalia ZC3H7B 35
  • 93.04 (n)
  • 97.29 (a)
mouse
(Mus musculus)
Mammalia Zc3h7b 36
  • 95 (a)
OneToOne
Zc3h7b 35
  • 90.43 (n)
  • 96.87 (a)
Zc3h7b 16
oppossum
(Monodelphis domestica)
Mammalia ZC3H7B 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H7B 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3h7b 35
  • 90.88 (n)
  • 96.56 (a)
chicken
(Gallus gallus)
Aves ZC3H7B 36
  • 76 (a)
OneToOne
ZC3H7B 35
  • 78.78 (n)
  • 84.14 (a)
lizard
(Anolis carolinensis)
Reptilia ZC3H7B 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12144 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9266 35
zc3h7b 35
  • 62.04 (n)
  • 59.27 (a)
zebrafish
(Danio rerio)
Actinopterygii zc3h7b 36
  • 43 (a)
OneToMany
ZC3H7B (2 of 3) 36
  • 40 (a)
OneToMany
ZC3H7B (3 of 3) 36
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for ZC3H7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H7B Gene

ENSEMBL:
Gene Tree for ZC3H7B (if available)
TreeFam:
Gene Tree for ZC3H7B (if available)

Paralogs for ZC3H7B Gene

Paralogs for ZC3H7B Gene

(1) SIMAP similar genes for ZC3H7B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZC3H7B: view

Variants for ZC3H7B Gene

Sequence variations from dbSNP and Humsavar for ZC3H7B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs9607793 - 41,340,086(+) CACTC(A/G)ACAGC nc-transcript-variant, reference, synonymous-codon, missense
rs3927 -- 41,326,860(+) TGCCA(C/T)TGTTA intron-variant
rs9538 -- 41,359,853(+) TCTGG(G/T)ACCTG utr-variant-3-prime
rs1807590 -- 41,313,231(+) ctcct(A/G)cctca intron-variant
rs1109151 -- 41,356,940(-) CCCCA(C/T)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H7B Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv915116 CNV Loss 21882294
nsv915118 CNV Loss 21882294
nsv915119 CNV Loss 21882294
nsv459888 CNV Gain 19166990
nsv817997 CNV Gain 17921354
nsv516925 CNV Loss 19592680
nsv915120 CNV Loss 21882294
nsv834207 CNV Loss 17160897
nsv3638 CNV Insertion 18451855
nsv915154 CNV Loss 21882294
dgv772n67 CNV Gain 20364138
nsv507937 CNV Insertion 20534489
nsv829242 CNV Gain 20364138

Variation tolerance for ZC3H7B Gene

Residual Variation Intolerance Score: 4.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H7B Gene

HapMap Linkage Disequilibrium report
ZC3H7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H7B Gene

Disorders for ZC3H7B Gene

Relevant External Links for ZC3H7B

Genetic Association Database (GAD)
ZC3H7B
Human Genome Epidemiology (HuGE) Navigator
ZC3H7B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H7B

No disorders were found for ZC3H7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H7B Gene

Publications for ZC3H7B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3
  3. Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation. (PMID: 23580382) Panagopoulos I. … Micci F. (Genes Chromosomes Cancer 2013) 3
  4. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ZC3H7B Gene

Sources for ZC3H7B Gene

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