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ZC3H7B Gene

protein-coding   GIFtS: 53

GC22P040023
zinc finger CCCH-type containing 7B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp434K0920 1, 2
FLJ13787 1, 2
KIAA1031 1, 2, 3
RoXaN 1, 2, 3
Descriptions
Rotavirus 'X' associated non-structural protein 2
Rotavirus 'X'-associated non-structural protein 3
rotavirus X protein associated with NSP3 2
ubiquitous tetratricopeptide containing protein RoXaN 2
zinc finger CCCH-type containing 7B 2
External Ids
HGNC: 308691
Entrez Gene: 232642
UniProtKB: Q9UGR23
Ensembl: ENSG000001004037
Search outside databases for aliases for ZC3H7B gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ZC3H7B:
This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein
also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq]

Gene Wiki entry for ZC3H7B
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZC3H7B gene  

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

ZC3H7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P040023:     (about GC identifiers)

Start:
40,027,475 bp from pter
End:
40,086,097 bp from pter
Size:
58,623 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000022.9  NT_011520.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: Z3H7B_HUMAN, Q9UGR2 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 7B  
Size: 993 amino acids; 111578 Da
Subunit: Interacts (via LD motif) with rotavirus A NSP3 (via the coiled-coil region)
Subcellular location: Nucleus. Note=Nuclear localization seems to be depleted upon rotavirus A
infection
Secondary accessions: A7YY88 B2RCA4 Q5TFX9 Q8TBT9 Q9H8B6 Q9UGQ9 Q9UGR0 Q9UGR1 Q9UK03 Q9UPW9
Alternative splicing: 2 isoforms:  Q9UGR2-1   Q9UGR2-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_060060.3  

    ENSEMBL proteins: 
    ENSP00000379783 ENSP00000345793 ENSP00000263243 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZC3H7B)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZC3H7B: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZC3H7B
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZC3H7B), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ZC3H7B

    Assays for ZC3H7B: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR000571 Znf_CCCH
     IPR011990 TPR-like_helical
     IPR015880 Znf_C2H2-like
     IPR001440 TPR-1
     IPR013026 TPR_region


       GeneDecks  ZC3H7B for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UGR2

    ProtoNet protein and cluster: Q9UGR2

    1 Blocks protein family: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: Z3H7B_HUMAN, Q9UGR2
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 4 C3H1-type zinc fingers
    Similarity: Contains 3 TPR repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZC3H7B)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZC3H7B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017590

                  Applied Biosystems Silencer® siRNAs for ZC3H7B

                  Sigma-Aldrich siRNA for ZC3H7B  
                         Sigma-Aldrich shRNA for ZC3H7B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017590
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017590
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_017590 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_017590

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding IEA--
    GO:0005515 protein binding IPI15047801
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    4 Interacting proteins for ZC3H7B (Q9UGR21, 2 ENSP000002632433) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    - - (xeno)Q007211EBI-948845, EBI-1263962
    ATXN1P542532MINT-2870822
    EIF4G1ENSP000003717673STRING (score=.757)
    --XM_292512.32MINT-2870841
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZC3H7B

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZC3H7B)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZC3H7B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017590

                  Sigma-Aldrich siRNA for ZC3H7B  
                         Sigma-Aldrich shRNA for ZC3H7B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_017590  

    REFSEQ mRNAs for ZC3H7B gene: 

    NM_017590.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_017590  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017590
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017590
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_017590 

    Additional cDNA sequence: 

    AB028954.1 AF188530.1 AK021658.1 AK130876.1 AK225891.1 AK315009.1 AL136802.1 BC024313.2 
    BC047002.1 BC056860.1 BC098378.1 BC127840.1 BC152558.1 CR626766.1 

    15 DOTS entries:

    DT.309578  DT.97793124  DT.120653885  DT.120653836  DT.100739744  DT.91749318  DT.95191635  DT.97842493 
    DT.40286943  DT.75108937  DT.120653844  DT.120653886  DT.95077466  DT.91749335  DT.95139385 

    24/184 AceView cDNA sequences (see all 184 ):

    AI765772 BE855831 AW839718 H55547 BQ052912 CR626766 AA737525 BG177232 
    AI821160 CN484543 BC024313 BC056860 BM712375 AI732128 AA588241 AI657066 
    H55396 BM707658 AW839717 AU141018 AW182888 AI028132 BM762209 AI686031 

    highest scoring ESTs for ZC3H7B:

    AB028954 AA573097 AA576988 AA587614 AA588241 AA628521 AA682958 AA935554 AI199264 AI266583 

    Unigene Cluster for ZC3H7B:

    Zinc finger CCCH-type containing 7B
    Hs.592188  [show with all ESTs]
    Unigene Representative Sequence: BC152558


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7B

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                                                  -                                         -           -           -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                            -                                                               
    SP4:                                                                                                        -                                                   
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              

    About this scheme

    ECgene alternative splicing isoforms for ZC3H7B

    3 Ensembl transcripts including schematic representations:
    ENST00000396532  ENST00000352645  ENST00000351589  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZC3H7B expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H7B

    1 / 2 / 3

    11 probe-sets matching ZC3H7B gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    35144_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB028954 1.00 1.00 1.00 1

    213323_s_at2, 3 U133-A 1 1.00 1.00 -- -- BE855831 0.80 1.00 0.91 1

    205877_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_017590 0.60 1.00 0.82 1

    216844_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    206169_x_at2, 3 U133-A 8 1.00 0.74 -- -- NM_025013 0.20 1.00 0.72 1

    206168_at*2, 3 U133-A NULL 0.00 0.00 -- -- NM_025013 0.20 1.00 0.72 1

    213323_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    205877_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    216844_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    206169_x_at2 U133Plus2 8 1.00 0.74 -- -- -- -- -- -- --

    206168_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGGGCGGGGT

    SOURCE GeneReport for Unigene cluster: Hs.592188
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZC3H7B gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZC3H7B1   -- zinc finger CCCH-type containing 7B 92.85(n)
    96.92(a)
    474490  XM_531719.2  XP_531719.2 
    chimpanzee
    (Pan troglodytes)
    ZC3H7B1   -- zinc finger CCCH-type containing 7B 98.91(n)
    99.08(a)
    458864  XM_001168979.1  XP_001168979.1 
    cow
    (Bos taurus)
    ZC3H7B1   -- zinc finger CCCH-type containing 7B 91.76(n)
    96.19(a)
    534109  XM_613763.3  XP_613763.3 
    rat
    (Rattus norvegicus)
    Zc3h7b1   -- zinc finger CCCH-type containing 7B 90.75(n)
    96.11(a)
    315158  XM_243630.4  XP_243630.3 
    mouse
    (Mus musculus)
    Zc3h7b1, 5 155
    zinc finger CCCH type containing 7B1, 5 90.34(n)1
    96.42(a)1
    202861  NM_001081016.11  NP_001074485.11 
     AJ2232075  AK1292685  (see all 14)
    About this table        Species with no ortholog for ZC3H7B

    ENSEMBL Gene Tree for ZC3H7B
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZC3H7B gene
    ZC3H7A2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/322 NCBI SNPs in ZC3H7B are shown (see all 322 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 95)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 22 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs95381,2
    A,C,F,H,O40085803(+) TCTGGG/TACCTG 1 -- ut31 ese34Minor allele frequency- T:0.19MN EU WA 612
    --
    rs60023501,2
    A,C,F,H40085732(+) TTAATG/CATGAG 1 -- ut314Minor allele frequency- C:0.11EU EA WA 412
    --
    rs121694431,2
    A,C,F,H40083974(+) GTCCCA/GGCCCT 1 -- ut31 ese34Minor allele frequency- G:0.08EU EA WA 406
    rs20245661,2
    C,F,H,O40027284(+) CCTAAA/GAGGCA 1 -- ng515Minor allele frequency- G:0.22MN EU EA WA 600
    rs57510841,2
    A,C,F,H40085051(+) AGGCCA/GGCACT 1 -- ut31 ese38Minor allele frequency- G:0.20EU EA WA 838
    rs22949791,2
    C,F,H40085768(+) CTAGGG/TCCCCA 1 -- ut31 ese35Minor allele frequency- T:0.28EA EU WA 1704
    rs37471821,2
    C,F,H40084601(+) CCGTCT/GGTCCT 1 -- ut316Minor allele frequency- G:0.01EA EU WA 2082
    rs96077931,2
    F,H40066036(+) CACTCG/AACAGC 1 N/D mis1 ese34Minor allele frequency- A:0.01EU EA WA 416
    rs10053051,2
    H40027097(+) CTATGT/GGTCTC 1 -- ng515Minor allele frequency- G:0.00NA EA MN EU 556
    --
    rs121587901,2
    A40026513(+) acctcA/Tggggt 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for ZC3H7B (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/12 PubMed articles for ZC3H7B gene (see all 12 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 23264 HGNC: 30869 AceView: RoXaN Ensembl:ENSG00000100403 euGenes: HUgn23264
    ECgene: ZC3H7B H-InvDB: ZC3H7B
    (According to HUGE)
    About This Section

    HUGE: KIAA1031
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZC3H7B:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for ZC3H7B Antibodies for ZC3H7B
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