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Aliases for ZC3H7B Gene

Aliases for ZC3H7B Gene

  • Zinc Finger CCCH-Type Containing 7B 2 3 5
  • Rotavirus X-Associated Non-Structural Protein 3 4
  • RoXaN 3 4
  • Ubiquitous Tetratricopeptide Containing Protein RoXaN 3
  • Rotavirus X Associated Non-Structural Protein 3
  • Zinc Finger CCCH Domain-Containing Protein 7B 3
  • Rotavirus X Protein Associated With NSP3 3
  • KIAA1031 4

External Ids for ZC3H7B Gene

Previous GeneCards Identifiers for ZC3H7B Gene

  • GC22P040023
  • GC22P041697
  • GC22P024664

Summaries for ZC3H7B Gene

Entrez Gene Summary for ZC3H7B Gene

  • This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZC3H7B Gene

ZC3H7B (Zinc Finger CCCH-Type Containing 7B) is a Protein Coding gene. Diseases associated with ZC3H7B include Myxoid Leiomyosarcoma and Endometrial Stromal Sarcoma. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is ZC3H7A.

Gene Wiki entry for ZC3H7B Gene

Additional gene information for ZC3H7B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H7B Gene

Genomics for ZC3H7B Gene

Regulatory Elements for ZC3H7B Gene

Enhancers for ZC3H7B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H041284 1.8 FANTOM5 ENCODE dbSUPER 21 -13.2 -13183 8.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 EP300 XRCC6 ENSG00000272834 EP300-AS1 ZC3H7B TEF ENSG00000232754 ENSG00000227413 ENSG00000235513 L3MBTL2
GH22H040709 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -589.3 -589331 6.3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF416 FOS EP300 XRCC6 PHF5A SLC25A17 L3MBTL2 DNAJB7 HMGN2P10 SNU13 ZC3H7B ENSG00000235513
GH22H040650 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -648.2 -648171 4.9 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 FOS SP3 XPNPEP3 GAPDHP37 MCHR1 L3MBTL2 LOC101927257 SLC25A17 ZC3H7B ST13 PMM1 ADSL
GH22H041961 0.9 ENCODE 19.9 +659.6 659589 0.2 ZNF493 ZFP64 ZEB1 ZNF302 ZNF138 SCRT2 ZNF654 SP3 ZNF680 ZC3H11A RN7SKP80 EP300 PHF5A POLDIP3 RPL5P34 NDUFA6 RRP7BP ENSG00000232754 XRCC6 ZC3H7B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC3H7B on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H7B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146609 597 1801 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF143 KLF7 RUNX3 SP3 SP5

Genomic Locations for ZC3H7B Gene

Genomic Locations for ZC3H7B Gene
58,645 bases
Plus strand

Genomic View for ZC3H7B Gene

Genes around ZC3H7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H7B Gene

Proteins for ZC3H7B Gene

  • Protein details for ZC3H7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCCH domain-containing protein 7B
    Protein Accession:
    Secondary Accessions:
    • A7YY88
    • B2RCA4
    • Q5TFX9
    • Q8TBT9
    • Q9H8B6
    • Q9UGQ9
    • Q9UGR0
    • Q9UGR1
    • Q9UK03
    • Q9UPW9

    Protein attributes for ZC3H7B Gene

    993 amino acids
    Molecular mass:
    111578 Da
    Quaternary structure:
    • Interacts (via LD motif) with rotavirus A NSP3 (via the coiled-coil region).

    Alternative splice isoforms for ZC3H7B Gene


neXtProt entry for ZC3H7B Gene

Post-translational modifications for ZC3H7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H7B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC3H7B Gene

Domains & Families for ZC3H7B Gene

Gene Families for ZC3H7B Gene

Suggested Antigen Peptide Sequences for ZC3H7B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZC3H7B: view

No data available for UniProtKB/Swiss-Prot for ZC3H7B Gene

Function for ZC3H7B Gene

Phenotypes From GWAS Catalog for ZC3H7B Gene

Gene Ontology (GO) - Molecular Function for ZC3H7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 15047801
GO:0035198 miRNA binding IDA 28431233
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H7B: view
genes like me logo Genes that share phenotypes with ZC3H7B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H7B Gene

Localization for ZC3H7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H7B Gene

Nucleus. Note=Nuclear localization seems to be depleted upon rotavirus A infection.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H7B gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZC3H7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZC3H7B: view

Pathways & Interactions for ZC3H7B Gene

SuperPathways for ZC3H7B Gene

No Data Available

Interacting Proteins for ZC3H7B Gene

Gene Ontology (GO) - Biological Process for ZC3H7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010608 posttranscriptional regulation of gene expression IMP 28431233
GO:0016032 viral process IEA --
GO:0035196 production of miRNAs involved in gene silencing by miRNA IMP 28431233
genes like me logo Genes that share ontologies with ZC3H7B: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H7B Gene

Drugs & Compounds for ZC3H7B Gene

No Compound Related Data Available

Transcripts for ZC3H7B Gene

mRNA/cDNA for ZC3H7B Gene

Unigene Clusters for ZC3H7B Gene

Zinc finger CCCH-type containing 7B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP3: -
SP4: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25

Relevant External Links for ZC3H7B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3H7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H7B Gene

This gene is overexpressed in Lung (13.0) and Fetal Brain (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZC3H7B Gene

Protein tissue co-expression partners for ZC3H7B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC3H7B Gene:


SOURCE GeneReport for Unigene cluster for ZC3H7B Gene:


Evidence on tissue expression from TISSUES for ZC3H7B Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZC3H7B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H7B Gene

Orthologs for ZC3H7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H7B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZC3H7B 33 34
  • 98.33 (n)
(Canis familiaris)
Mammalia ZC3H7B 33
  • 93.04 (n)
(Bos Taurus)
Mammalia ZC3H7B 33 34
  • 91.92 (n)
(Rattus norvegicus)
Mammalia Zc3h7b 33
  • 90.88 (n)
(Mus musculus)
Mammalia Zc3h7b 33 16 34
  • 90.43 (n)
(Monodelphis domestica)
Mammalia ZC3H7B 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ZC3H7B 34
  • 68 (a)
(Gallus gallus)
Aves ZC3H7B 33 34
  • 78.78 (n)
(Anolis carolinensis)
Reptilia ZC3H7B 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h7b 33
  • 62.04 (n)
Str.9266 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12144 33
(Danio rerio)
Actinopterygii ZC3H7B (3 of 3) 34
  • 47 (a)
zc3h7b 34
  • 43 (a)
ZC3H7B (2 of 3) 34
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for ZC3H7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H7B Gene

Gene Tree for ZC3H7B (if available)
Gene Tree for ZC3H7B (if available)

Paralogs for ZC3H7B Gene

Paralogs for ZC3H7B Gene

(1) SIMAP similar genes for ZC3H7B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZC3H7B: view

Variants for ZC3H7B Gene

Sequence variations from dbSNP and Humsavar for ZC3H7B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000010921 -- 41,357,628(+) CCCCG(A/G)AGGCC utr-variant-3-prime
rs1000023413 -- 41,349,876(+) CCTGT(A/G)TTCCA intron-variant
rs1000043465 -- 41,357,922(+) TGGAG(C/G)TGGGA utr-variant-3-prime
rs1000076835 -- 41,351,730(+) ACAAT(A/T)GAGAA intron-variant
rs1000097745 -- 41,327,341(+) GCAGC(C/T)GGTGT reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZC3H7B Gene

Variant ID Type Subtype PubMed ID
nsv834207 CNV loss 17160897
nsv829242 CNV gain 20364138
nsv817997 CNV gain 17921354
nsv589050 CNV gain 21841781
nsv524585 CNV loss 19592680
nsv516925 CNV loss 19592680
nsv507937 OTHER sequence alteration 20534489
nsv479224 CNV novel sequence insertion 20440878
nsv459888 CNV gain 19166990
nsv3638 CNV insertion 18451855
dgv772n67 CNV gain 20364138

Variation tolerance for ZC3H7B Gene

Residual Variation Intolerance Score: 4.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H7B Gene

Disorders for ZC3H7B Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZC3H7B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myxoid leiomyosarcoma
  • leiomyosarcoma, myxoid
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZC3H7B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZC3H7B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZC3H7B Gene

Publications for ZC3H7B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN. (PMID: 18799579) Harb M … Poncet D (Journal of virology 2008) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. RoXaN, a novel cellular protein containing TPR, LD, and zinc finger motifs, forms a ternary complex with eukaryotic initiation factor 4G and rotavirus NSP3. (PMID: 15047801) Vitour D … Poncet D (Journal of virology 2004) 3 4 60

Products for ZC3H7B Gene

Sources for ZC3H7B Gene

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