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Aliases & Descriptions for ZC3H7B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp434K0920 1, 2 | | FLJ13787 1, 2 | | KIAA1031 1, 2, 3 | | RoXaN 1, 2, 3 |
| | | Descriptions |
|---|
| Rotavirus 'X' associated non-structural protein 2 | | Rotavirus 'X'-associated non-structural protein 3 | | rotavirus X protein associated with NSP3 2 | | ubiquitous tetratricopeptide containing protein RoXaN 2 | | zinc finger CCCH-type containing 7B 2 |
|
| | Search outside databases for aliases for ZC3H7B gene |
Summaries for ZC3H7B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ZC3H7B: This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq] Gene Wiki entry for ZC3H7B |
Genomic Location for ZC3H7B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ZC3H7B gene 
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2ZC3H7B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P040023:
(about GC identifiers)
Start:
|
40,027,475 bp from pter |
End:
|
40,086,097 bp from pter |
Size:
|
58,623 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000022.9 NT_011520.11
| Proteins for ZC3H7B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: Z3H7B_HUMAN, Q9UGR2 (See
protein sequence)Recommended Name: Zinc finger CCCH domain-containing protein 7B Size: 993 amino acids; 111578 Da
Subunit: Interacts (via LD motif) with rotavirus A NSP3 (via the coiled-coil region)
Subcellular location: Nucleus. Note=Nuclear localization seems to be depleted upon rotavirus A infection
Secondary accessions: A7YY88 B2RCA4 Q5TFX9 Q8TBT9 Q9H8B6 Q9UGQ9 Q9UGR0 Q9UGR1 Q9UK03 Q9UPW9Alternative splicing: 2 isoforms: Q9UGR2-1 Q9UGR2-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060060.3
ENSEMBL proteins: ENSP00000379783 ENSP00000345793 ENSP00000263243
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ZC3H7B: Assays for ZC3H7B: | Protein
Domains/ Families for ZC3H7B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UGR2
ProtoNet protein and cluster: Q9UGR2 1 Blocks protein family: IPB000571 Zn-finger
UniProtKB/Swiss-Prot: Z3H7B_HUMAN, Q9UGR2Similarity: Contains 1 C2H2-type zinc fingerSimilarity: Contains 4 C3H1-type zinc fingersSimilarity: Contains 3 TPR repeats | Gene Function for ZC3H7B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017590
Applied Biosystems Silencer® siRNAs for ZC3H7B
Sigma-Aldrich siRNA for ZC3H7B  Sigma-Aldrich shRNA for ZC3H7B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017590                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017590                                  untagged cDNA clones in CMV expression vector (see all 2): NM_017590 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_017590
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ZC3H7B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for ZC3H7B (Q9UGR21, 2 ENSP000002632433) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for ZC3H7B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ZC3H7B
|
Transcripts for ZC3H7B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017590
Sigma-Aldrich siRNA for ZC3H7B  Sigma-Aldrich shRNA for ZC3H7B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_017590 REFSEQ mRNAs for ZC3H7B gene: NM_017590.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_017590               OriGene GFP tagged cDNA clone in CMV expression vector: NM_017590                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017590                                  untagged cDNA clones in CMV expression vector (see all 2): NM_017590  Additional cDNA sequence: AB028954.1 AF188530.1 AK021658.1 AK130876.1 AK225891.1 AK315009.1 AL136802.1 BC024313.2 BC047002.1 BC056860.1 BC098378.1 BC127840.1 BC152558.1 CR626766.1 15 DOTS entries: DT.309578 DT.97793124 DT.120653885 DT.120653836 DT.100739744 DT.91749318 DT.95191635 DT.97842493 DT.40286943 DT.75108937 DT.120653844 DT.120653886 DT.95077466 DT.91749335 DT.95139385 24/184 AceView cDNA sequences (see all 184
):AI765772 BE855831 AW839718 H55547 BQ052912 CR626766 AA737525 BG177232 AI821160 CN484543 BC024313 BC056860 BM712375 AI732128 AA588241 AI657066 H55396 BM707658 AW839717 AU141018 AW182888 AI028132 BM762209 AI686031
highest scoring ESTs for ZC3H7B:AB028954 AA573097 AA576988 AA587614 AA588241 AA628521 AA682958 AA935554 AI199264 AI266583 Unigene Cluster for ZC3H7B: Zinc finger CCCH-type containing 7B Hs.592188 [show with all ESTs]Unigene Representative Sequence: BC152558
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7B
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | |
| SP1: | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ZC3H7B
3 Ensembl transcripts including schematic representations: ENST00000396532
ENST00000352645
ENST00000351589
|
Expression for ZC3H7B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZC3H7B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H7B
1 / 2 / 3 11 probe-sets matching ZC3H7B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGGCGGGGT
SOURCE GeneReport for Unigene cluster: Hs.592188
|
Orthologs for ZC3H7B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZC3H7B gene from 5/8 species (see all 8
)
About this table Species with no ortholog for ZC3H7B
ENSEMBL Gene Tree for ZC3H7B | Paralogs for ZC3H7B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ZC3H7B gene
- ZC3H7A2
|
SNPs/Variants for ZC3H7B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ZC3H7B (up to first 250kb)
|
Disorders & Mutations for ZC3H7B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for ZC3H7B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ZC3H7B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for ZC3H7B gene (see all 12
):- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)2, 3, 4 Kikuno R....Ohara O. (1999)
- Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN. (PubMed id 18799579)3, 4 Harb M....Poncet D. (2008)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)3, 4 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- RoXaN, a novel cellular protein containing TPR, LD, and zinc finger motifs, forms a ternary complex with eukaryotic initiation factor 4G and rotavirus NSP3. (PubMed id 15047801)3, 4 Vitour D....Poncet D. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)2, 3 Wiemann S.... Poustka A. (2001)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)3, 4 Dunham I....O'Brien K.P. (1999)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)3 Lim J....Zoghbi H.Y. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for ZC3H7B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZC3H7B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZC3H7B
(According to HUGE)
About This Section
| |
Specialized Databases showing ZC3H7B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ZC3H7B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ZC3H7B:

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Incremental update: 13 Oct 2009
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