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Aliases for ZC3H7A Gene

Aliases for ZC3H7A Gene

  • Zinc Finger CCCH-Type Containing 7A 2 3 5
  • Zinc Finger CCCH-Type Domain Containing 7 2 3
  • ZC3HDC7 3 4
  • ZC3H7 3 4
  • Zinc Finger CCCH Type Domain Containing 7 3
  • Zinc Finger CCCH-Type Containing 7 2
  • Zinc-Finger Protein AY163807 3
  • HSPC055 3

External Ids for ZC3H7A Gene

Previous HGNC Symbols for ZC3H7A Gene

  • ZC3HDC7
  • ZC3H7

Previous GeneCards Identifiers for ZC3H7A Gene

  • GC16M011752
  • GC16M011845
  • GC16M011846
  • GC16M011848
  • GC16M011849

Summaries for ZC3H7A Gene

GeneCards Summary for ZC3H7A Gene

ZC3H7A (Zinc Finger CCCH-Type Containing 7A) is a Protein Coding gene. Diseases associated with ZC3H7A include Endometrial Stromal Sarcoma. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is ZC3H7B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H7A Gene

Genomics for ZC3H7A Gene

Regulatory Elements for ZC3H7A Gene

Enhancers for ZC3H7A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZC3H7A on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZC3H7A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC3H7A Gene

11,750,586 bp from pter
11,797,267 bp from pter
46,682 bases
Minus strand

Genomic View for ZC3H7A Gene

Genes around ZC3H7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H7A Gene

Proteins for ZC3H7A Gene

  • Protein details for ZC3H7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCCH domain-containing protein 7A
    Protein Accession:
    Secondary Accessions:
    • D3DUG5
    • Q9NPE9

    Protein attributes for ZC3H7A Gene

    971 amino acids
    Molecular mass:
    110538 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZC3H7A Gene

    Alternative splice isoforms for ZC3H7A Gene


neXtProt entry for ZC3H7A Gene

Proteomics data for ZC3H7A Gene at MOPED

Post-translational modifications for ZC3H7A Gene

  • Ubiquitination at Lys 425 and Lys 709
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZC3H7A Gene

Domains & Families for ZC3H7A Gene

Protein Domains for ZC3H7A Gene

Suggested Antigen Peptide Sequences for ZC3H7A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2H2-type zinc finger.
  • Contains 1 C2H2-type zinc finger.
  • Contains 3 C3H1-type zinc fingers.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with ZC3H7A: view

Function for ZC3H7A Gene

Phenotypes for ZC3H7A Gene

GenomeRNAi human phenotypes for ZC3H7A:
genes like me logo Genes that share phenotypes with ZC3H7A: view

Animal Model Products

miRNA for ZC3H7A Gene

miRTarBase miRNAs that target ZC3H7A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H7A Gene

Localization for ZC3H7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H7A Gene

Subcellular locations from

Jensen Localization Image for ZC3H7A Gene COMPARTMENTS Subcellular localization image for ZC3H7A gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZC3H7A Gene

Pathways & Interactions for ZC3H7A Gene

SuperPathways for ZC3H7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H7A Gene


No data available for Pathways by source and SIGNOR curated interactions for ZC3H7A Gene

Drugs & Compounds for ZC3H7A Gene

No Compound Related Data Available

Transcripts for ZC3H7A Gene

Unigene Clusters for ZC3H7A Gene

Zinc finger CCCH-type containing 7A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - - - - -
SP2: -
SP3: - - - - - - -
SP4: - - - - - -
SP6: - -
SP7: - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: -

ExUns: 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
SP1: -
SP2: -
SP5: - -
SP12: -

Relevant External Links for ZC3H7A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H7A Gene

mRNA expression in normal human tissues for ZC3H7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H7A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.8), Platelet (9.6), and Placenta (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3H7A Gene

SOURCE GeneReport for Unigene cluster for ZC3H7A Gene Hs.371856

genes like me logo Genes that share expression patterns with ZC3H7A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZC3H7A Gene

Orthologs for ZC3H7A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H7A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZC3H7A 35
  • 90.77 (n)
  • 94.03 (a)
ZC3H7A 36
  • 94 (a)
(Canis familiaris)
Mammalia ZC3H7A 35
  • 92.28 (n)
  • 94.34 (a)
ZC3H7A 36
  • 94 (a)
(Mus musculus)
Mammalia Zc3h7a 35
  • 87.16 (n)
  • 85.54 (a)
Zc3h7a 16
Zc3h7a 36
  • 85 (a)
(Pan troglodytes)
Mammalia ZC3H7A 35
  • 99.76 (n)
  • 99.59 (a)
ZC3H7A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zc3h7a 35
  • 86.03 (n)
  • 86.55 (a)
(Monodelphis domestica)
Mammalia ZC3H7A 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
-- 36
  • 68 (a)
-- 36
  • 83 (a)
-- 36
  • 65 (a)
(Gallus gallus)
Aves ZC3H7A 35
  • 76.16 (n)
  • 74.33 (a)
ZC3H7A 36
  • 73 (a)
(Anolis carolinensis)
Reptilia ZC3H7A 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11347 35
zc3h7a 35
  • 62.81 (n)
  • 57.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13783 35
(Danio rerio)
Actinopterygii wufa12e01 35
zc3h7a 35
  • 60.28 (n)
  • 55.8 (a)
zc3h7a 36
  • 51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11063 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for ZC3H7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H7A Gene

Gene Tree for ZC3H7A (if available)
Gene Tree for ZC3H7A (if available)

Paralogs for ZC3H7A Gene

Paralogs for ZC3H7A Gene

(1) SIMAP similar genes for ZC3H7A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZC3H7A: view

Variants for ZC3H7A Gene

Sequence variations from dbSNP and Humsavar for ZC3H7A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1429077 - 11,782,347(-) GTCCA(A/G/T)TGTGT nc-transcript-variant, reference, missense
rs16958654 - 11,779,302(+) AATCA(C/T)GTTCC nc-transcript-variant, reference, missense
rs7090 -- 11,750,799(-) ATGGG(G/T)TATTT nc-transcript-variant, utr-variant-3-prime
rs8743 -- 11,758,498(-) TATGT(G/T)GGAAA nc-transcript-variant, reference, synonymous-codon
rs3960407 -- 11,798,194(+) GGAGA(A/G)AGATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZC3H7A Gene

Variant ID Type Subtype PubMed ID
esv2674286 CNV Deletion 23128226
esv21664 CNV Loss 19812545

Variation tolerance for ZC3H7A Gene

Residual Variation Intolerance Score: 8.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZC3H7A Gene

Disorders for ZC3H7A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZC3H7A Gene - From: DISEASES

Disorder Aliases PubMed IDs
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZC3H7A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZC3H7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZC3H7A Gene

Publications for ZC3H7A Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for ZC3H7A Gene

Sources for ZC3H7A Gene