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ZC3H7A Gene

protein-coding   GIFtS: 51

GC16M011752
zinc finger CCCH-type containing 7A
(Previous names: zinc finger CCCH-type domain containing 7, zinc finger CCCH-type containing 7 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ZC3HDC7, ZC3H7)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ10027 2
FLJ20318 1, 2
HSPC055 1, 2
ZC3H7 2, 3
ZC3HDC7 2, 3
Descriptions
zinc finger CCCH type domain containing 7 2
zinc finger CCCH-type containing 7 1
zinc finger CCCH-type containing 7A 2
zinc finger CCCH-type domain containing 7 1, 2
zinc-finger protein AY163807 2
External Ids
HGNC: 309591
Entrez Gene: 290662
UniProtKB: Q8IWR03
Ensembl: ENSG000001222997
Search outside databases for aliases for ZC3H7A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZC3H7A gene  

Entrez Gene cytogenetic band: 16p13-p12   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13-p12

ZC3H7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M011752:     (about GC identifiers)

Start:
11,751,943 bp from pter
End:
11,798,508 bp from pter
Size:
46,566 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000016.8  NT_010393.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: Z3H7A_HUMAN, Q8IWR0 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 7A  
Size: 971 amino acids; 110538 Da
Subcellular location: Nucleus (Probable)
PDB structures from and Proteopedia :
2D9M (3D)    
Secondary accessions: Q9NPE9
Alternative splicing: 2 isoforms:  Q8IWR0-1   Q8IWR0-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_054872.2  

    ENSEMBL proteins: 
    ENSP00000379773 ENSP00000347999 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZC3H7A)
    Human Recombinant Proteins from Abnova (ZC3H7A)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZC3H7A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZC3H7A), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ZC3H7A)
    Novus Biologicals Antibody for ZC3H7A

    Assays for ZC3H7A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR000571 Znf_CCCH
     IPR011990 TPR-like_helical
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2


       GeneDecks  ZC3H7A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8IWR0

    ProtoNet protein and cluster: Q8IWR0

    1 Blocks protein family: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: Z3H7A_HUMAN, Q8IWR0
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 3 C3H1-type zinc fingers
    Similarity: Contains 3 TPR repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZC3H7A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZC3H7A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014153

                  Applied Biosystems Silencer® siRNAs for ZC3H7A

                  Sigma-Aldrich siRNA for ZC3H7A  
                         Sigma-Aldrich shRNA for ZC3H7A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ZC3H7A
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014153
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014153
                                     untagged cDNA clones in CMV expression vector (see all 4): AK000325 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_014153

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    3 Interacting proteins for ZC3H7A (ENSP000003479993 Q8IWR02) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL7A1Q023882MINT-64033
    LENG9ENSP000003316473STRING (score=.712)
    ZC3H12DENSP000003745923STRING (score=.7)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZC3H7A

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZC3H7A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZC3H7A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014153

                  Sigma-Aldrich siRNA for ZC3H7A  
                         Sigma-Aldrich shRNA for ZC3H7A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_014153  

    REFSEQ mRNAs for ZC3H7A gene: 

    NM_014153.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_014153  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014153
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014153
                                     untagged cDNA clones in CMV expression vector (see all 4): AK000325 

    Additional cDNA sequence: 

    AF161540.1 AK000325.1 AK000889.1 AK001869.1 AK026827.1 AK026956.1 AK091803.1 AY163807.1 
    BC012575.1 BC036857.1 BC046363.1 BX647154.1 

    16 DOTS entries:

    DT.412585  DT.92412905  DT.315921  DT.100035822  DT.100755449  DT.101981765  DT.75131791  DT.100682919 
    DT.120686289  DT.120686252  DT.97795647  DT.100811130  DT.120686273  DT.91761840  DT.95306585  DT.91761844 

    24/223 AceView cDNA sequences (see all 223 ):

    AI347278 BU165504 AI086263 BM476432 BX479838 AI690260 CA391605 BM509935 
    BQ027548 AI741810 AI815665 AI446385 AI620423 BC046363 BM458205 AI400371 
    CK820122 BX955178 AI023771 BM801931 AA235613 BM463349 CA446766 BM354212 

    highest scoring ESTs for ZC3H7A:

    AA885491 AI347278 AK091803 AY163807 BC036857 BC046363 BM469972 BM541920 BQ430708 BU165504 

    Unigene Cluster for ZC3H7A:

    Zinc finger CCCH-type containing 7A
    Hs.371856  [show with all ESTs]
    Unigene Representative Sequence: NM_014153


    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7A (see all 14 )

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:                    -     -     -     -     -                 -                                                                 -                 -     -   
    SP2:                                                                                                                                -                           
    SP3:                    -     -     -     -     -                 -                                                                 -                           
    SP4:                    -     -     -     -     -                 -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
    SP1:                                            -                                                                           
    SP2:                                            -                                                                           
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                            -                             -                                             

    About this scheme

    ECgene alternative splicing isoforms for ZC3H7A

    2 Ensembl transcripts including schematic representations:
    ENST00000396516  ENST00000355758  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZC3H7A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H7A

    1 / 2 / 3

    7 probe-sets matching ZC3H7A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    63401_at2, 3 U95-C 1 1.00 1.00 0.93 1.26 C06463 0.20 1.00 0.72 1
    60818_at2, 3 U95-C 1 1.00 1.00 0.58 0.82 AI347278 0.80 1.00 0.91 1

    90991_at2, 3 U95-E 1 0.75 1.00 0.91 0.92 AA885491 0.80 1.00 0.91 1

    226897_s_at2, 3 U133-B 1 1.00 1.00 -- -- AW169959 0.60 1.00 0.82 1

    218348_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014153 0.60 1.00 0.82 1

    226897_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    218348_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ZC3H7A for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.371856
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZC3H7A gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZC3H7A1   -- zinc finger CCCH-type containing 7A 92.28(n)
    94.34(a)
    479848  XM_536973.2  XP_536973.2 
    chimpanzee
    (Pan troglodytes)
    ZC3H7A1   -- zinc finger CCCH-type containing 7A 99.76(n)
    99.59(a)
    737804  XM_001144154.1  XP_001144154.1 
    cow
    (Bos taurus)
    ZC3H7A1   -- zinc finger CCCH-type containing 7A 90.77(n)
    94.03(a)
    540922  XM_864178.2  XP_869271.1 
    rat
    (Rattus norvegicus)
    Zc3h7a1   -- zinc finger CCCH type containing 7 A 86.48(n)
    86.48(a)
    360466  XM_340742.3  XP_340743.2 
    mouse
    (Mus musculus)
    Zc3h7a1, 5 165
    zinc finger CCCH type containing 7 A1, 5 87.27(n)1
    85.35(a)1
    1062051  NM_145931.11  NP_666043.11 
     AA9829045  AI4472945  (see all 22)
    About this table        Species with no ortholog for ZC3H7A

    ENSEMBL Gene Tree for ZC3H7A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZC3H7A gene
    ZC3H7B2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/211 NCBI SNPs in ZC3H7A are shown (see all 211 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 73)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs14290771,2
    C,F,H11783704(-) GTCCAA/GTGTGT 1 N/S mis1 ese311Minor allele frequency- G:0.05EU EA WA NA 978
    rs169586541,2
    C,F,H11780659(+) AATCAT/CGTTCC 1 R/H mis115Minor allele frequency- C:0.05NA EU EA WA 1402
    rs14290751,2
    C,F,H11784925(-) AGACAT/CTTTTG 1 -- ng314Minor allele frequency- C:0.01EU EA WA 416
    --
    rs80490221,2
    A,C11784855(+) CAGGAC/TATTGG 1 -- ng310--------
    rs133305501,2
    F,H11785577(+) TGCCAA/CAAATA 1 -- ng314Minor allele frequency- C:0.08EU EA WA 356
    rs80505501,2
    C,F11751493(+) ACCCAG/TAAAAA 1 -- ng514Minor allele frequency- T:0.23NA EA 362
    --
    rs14290761,2
    A,C11784856(-) GCCAAC/TGTCCT 1 -- ng310--------
    --
    rs110750131,2
    A,C11783987(+) TGAGAC/TGGAGT 1 -- ng310--------
    rs116399071,2
    H11783746(+) GCAATC/TTGGAA 1 -- ut51 spl34Minor allele frequency- T:0.00EU EA WA 418
    rs87431,2
    A,C,F11759855(-) TATGTT/GGGAAA 1 V/V syn12Minor allele frequency- G:0.41MN 372
    About this table

    HapMap Linkage Disequilibrium images for ZC3H7A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    7 PubMed articles for ZC3H7A gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 29066 HGNC: 30959 AceView: ZC3HDC7 Ensembl:ENSG00000122299 euGenes: HUgn29066
    ECgene: ZC3H7A H-InvDB: ZC3H7A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZC3H7A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for ZC3H7A Browse antibodies at Sigma-Aldrich
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     Lentivirus-delivered shRNAs for ZC3H7A Browse small molecules at Sigma-Aldrich
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     Antibodies for ZC3H7A

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