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Aliases for ZC3H7A Gene

Aliases for ZC3H7A Gene

  • Zinc Finger CCCH-Type Containing 7A 2 3 5
  • Zinc Finger CCCH-Type Domain Containing 7 2 3
  • ZC3HDC7 3 4
  • ZC3H7 3 4
  • Zinc Finger CCCH Domain-Containing Protein 7A 3
  • Zinc Finger CCCH-Type Containing 7 2
  • Zinc-Finger Protein AY163807 3
  • HSPC055 3

External Ids for ZC3H7A Gene

Previous HGNC Symbols for ZC3H7A Gene

  • ZC3HDC7
  • ZC3H7

Previous GeneCards Identifiers for ZC3H7A Gene

  • GC16M011752
  • GC16M011845
  • GC16M011846
  • GC16M011848
  • GC16M011849

Summaries for ZC3H7A Gene

GeneCards Summary for ZC3H7A Gene

ZC3H7A (Zinc Finger CCCH-Type Containing 7A) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is ZC3H7B.

Additional gene information for ZC3H7A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H7A Gene

Genomics for ZC3H7A Gene

Regulatory Elements for ZC3H7A Gene


Enhancers around ZC3H7A on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083395 -33 2601 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for ZC3H7A Gene

Chromosome:
16
Start:
11,750,586 bp from pter
End:
11,797,267 bp from pter
Size:
46,682 bases
Orientation:
Minus strand

Genomic View for ZC3H7A Gene

Genes around ZC3H7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H7A Gene

Proteins for ZC3H7A Gene

  • Protein details for ZC3H7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWR0-Z3H7A_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 7A
    Protein Accession:
    Q8IWR0
    Secondary Accessions:
    • D3DUG5
    • Q9NPE9

    Protein attributes for ZC3H7A Gene

    Size:
    971 amino acids
    Molecular mass:
    110538 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZC3H7A Gene

    Alternative splice isoforms for ZC3H7A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H7A Gene

Post-translational modifications for ZC3H7A Gene

  • Ubiquitination at Lys425 and Lys709
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZC3H7A Gene

Domains & Families for ZC3H7A Gene

Gene Families for ZC3H7A Gene

Protein Domains for ZC3H7A Gene

Suggested Antigen Peptide Sequences for ZC3H7A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZC3H7A: view

No data available for UniProtKB/Swiss-Prot for ZC3H7A Gene

Function for ZC3H7A Gene

Phenotypes From GWAS Catalog for ZC3H7A Gene

Gene Ontology (GO) - Molecular Function for ZC3H7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0035198 miRNA binding IDA 28431233
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H7A: view

Phenotypes for ZC3H7A Gene

GenomeRNAi human phenotypes for ZC3H7A:
genes like me logo Genes that share phenotypes with ZC3H7A: view

Animal Model Products

CRISPR Products

miRNA for ZC3H7A Gene

miRTarBase miRNAs that target ZC3H7A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZC3H7A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H7A Gene

Localization for ZC3H7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H7A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H7A gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZC3H7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZC3H7A: view

Pathways & Interactions for ZC3H7A Gene

SuperPathways for ZC3H7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010608 posttranscriptional regulation of gene expression IMP 28431233
GO:0035196 production of miRNAs involved in gene silencing by miRNA IMP 28431233
genes like me logo Genes that share ontologies with ZC3H7A: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H7A Gene

Drugs & Compounds for ZC3H7A Gene

No Compound Related Data Available

Transcripts for ZC3H7A Gene

Unigene Clusters for ZC3H7A Gene

Zinc finger CCCH-type containing 7A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZC3H7A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - - - - -
SP2: -
SP3: - - - - - - -
SP4: - - - - - -
SP5:
SP6: - -
SP7: - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
SP1: -
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for ZC3H7A Gene

GeneLoc Exon Structure for
ZC3H7A
ECgene alternative splicing isoforms for
ZC3H7A

Expression for ZC3H7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3H7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H7A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.8), Platelet (9.6), and Placenta (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC3H7A Gene



NURSA nuclear receptor signaling pathways regulating expression of ZC3H7A Gene:

ZC3H7A

SOURCE GeneReport for Unigene cluster for ZC3H7A Gene:

Hs.371856

Evidence on tissue expression from TISSUES for ZC3H7A Gene

  • Liver(4.2)
  • Muscle(4.2)
  • Skin(4.2)
  • Blood(4.1)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with ZC3H7A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H7A Gene

Orthologs for ZC3H7A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H7A 33 34
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia ZC3H7A 33 34
  • 92.28 (n)
cow
(Bos Taurus)
Mammalia ZC3H7A 33 34
  • 90.77 (n)
mouse
(Mus musculus)
Mammalia Zc3h7a 33 16 34
  • 87.16 (n)
rat
(Rattus norvegicus)
Mammalia Zc3h7a 33
  • 86.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZC3H7A 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H7A 33 34
  • 76.16 (n)
lizard
(Anolis carolinensis)
Reptilia ZC3H7A 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h7a 33
  • 62.81 (n)
Str.11347 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13783 33
zebrafish
(Danio rerio)
Actinopterygii zc3h7a 33 34
  • 60.28 (n)
wufa12e01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11063 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToMany
Species where no ortholog for ZC3H7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H7A Gene

ENSEMBL:
Gene Tree for ZC3H7A (if available)
TreeFam:
Gene Tree for ZC3H7A (if available)

Paralogs for ZC3H7A Gene

Paralogs for ZC3H7A Gene

(1) SIMAP similar genes for ZC3H7A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZC3H7A: view

Variants for ZC3H7A Gene

Sequence variations from dbSNP and Humsavar for ZC3H7A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000014974 -- 11,780,542(+) TTATT(G/T)TAGAA intron-variant, upstream-variant-2KB
rs1000031665 -- 11,785,715(+) CCCGG(C/G/T)ATCAC intron-variant
rs1000076753 -- 11,779,503(+) ATGCA(A/G)CCCAA intron-variant, upstream-variant-2KB
rs1000166144 -- 11,791,050(+) CTGGG(A/G)TACAG intron-variant
rs1000233847 -- 11,767,726(+) AGTAG(G/T)CTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H7A Gene

Variant ID Type Subtype PubMed ID
esv21664 CNV loss 19812545
esv2674286 CNV deletion 23128226
esv3637939 CNV loss 21293372
nsv1043909 CNV gain 25217958
nsv1123009 CNV deletion 24896259
nsv1126416 CNV deletion 24896259
nsv1138415 CNV deletion 24896259

Variation tolerance for ZC3H7A Gene

Residual Variation Intolerance Score: 8.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H7A Gene

Disorders for ZC3H7A Gene

Relevant External Links for ZC3H7A

Genetic Association Database (GAD)
ZC3H7A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H7A

No disorders were found for ZC3H7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H7A Gene

Publications for ZC3H7A Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 60
  2. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C … Stricker BH (Nature genetics 2009) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ZC3H7A Gene

Sources for ZC3H7A Gene

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