ZC3H7A Gene
protein-coding GIFtS: 51
GC16M011752
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zinc finger CCCH-type containing 7A (Previous names: zinc finger CCCH-type domain containing 7, zinc finger CCCH-type containing 7 ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: ZC3HDC7, ZC3H7)
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Aliases & Descriptions for ZC3H7A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
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| FLJ10027 2 | | FLJ20318 1, 2 | | HSPC055 1, 2 | | ZC3H7 2, 3 | | ZC3HDC7 2, 3 |
| | | Descriptions |
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| zinc finger CCCH type domain containing 7 2 | | zinc finger CCCH-type containing 7 1 | | zinc finger CCCH-type containing 7A 2 | | zinc finger CCCH-type domain containing 7 1, 2 | | zinc-finger protein AY163807 2 |
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| | Search outside databases for aliases for ZC3H7A gene |
Summaries for ZC3H7A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Genomic Location for ZC3H7A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ZC3H7A gene 
Entrez Gene cytogenetic band: 16p13-p12 Ensembl cytogenetic band: 16p13.13 HGNC cytogenetic band: 16p13-p12ZC3H7A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M011752:
(about GC identifiers)
Start:
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11,751,943 bp from pter |
End:
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11,798,508 bp from pter |
Size:
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46,566 bases |
Orientation:
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minus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010393.15
| Proteins for ZC3H7A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: Z3H7A_HUMAN, Q8IWR0 (See
protein sequence)Recommended Name: Zinc finger CCCH domain-containing protein 7A Size: 971 amino acids; 110538 Da
Subcellular location: Nucleus (Probable)
PDB structures from and Proteopedia :2D9M (3D)
 
Secondary accessions: Q9NPE9Alternative splicing: 2 isoforms: Q8IWR0-1 Q8IWR0-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_054872.2
ENSEMBL proteins: ENSP00000379773 ENSP00000347999
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ZC3H7A: Assays for ZC3H7A: | Protein
Domains/ Families for ZC3H7A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8IWR0
ProtoNet protein and cluster: Q8IWR0 1 Blocks protein family: IPB000571 Zn-finger
UniProtKB/Swiss-Prot: Z3H7A_HUMAN, Q8IWR0Similarity: Contains 1 C2H2-type zinc fingerSimilarity: Contains 3 C3H1-type zinc fingersSimilarity: Contains 3 TPR repeats | Gene Function for ZC3H7A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014153
Applied Biosystems Silencer® siRNAs for ZC3H7A
Sigma-Aldrich siRNA for ZC3H7A  Sigma-Aldrich shRNA for ZC3H7A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014153                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014153                                  untagged cDNA clones in CMV expression vector (see all 4): AK000325 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014153
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ZC3H7A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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3 Interacting proteins for ZC3H7A (ENSP000003479993 Q8IWR02) via UniProtKB, MINT, and/or STRINGAbout this table
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Drugs & Compounds for ZC3H7A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for ZC3H7A
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Transcripts for ZC3H7A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014153
Sigma-Aldrich siRNA for ZC3H7A  Sigma-Aldrich shRNA for ZC3H7A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014153 REFSEQ mRNAs for ZC3H7A gene: NM_014153.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014153               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014153                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014153                                  untagged cDNA clones in CMV expression vector (see all 4): AK000325  Additional cDNA sequence: AF161540.1 AK000325.1 AK000889.1 AK001869.1 AK026827.1 AK026956.1 AK091803.1 AY163807.1 BC012575.1 BC036857.1 BC046363.1 BX647154.1 16 DOTS entries: DT.412585 DT.92412905 DT.315921 DT.100035822 DT.100755449 DT.101981765 DT.75131791 DT.100682919 DT.120686289 DT.120686252 DT.97795647 DT.100811130 DT.120686273 DT.91761840 DT.95306585 DT.91761844 24/223 AceView cDNA sequences (see all 223
):AI347278 BU165504 AI086263 BM476432 BX479838 AI690260 CA391605 BM509935 BQ027548 AI741810 AI815665 AI446385 AI620423 BC046363 BM458205 AI400371 CK820122 BX955178 AI023771 BM801931 AA235613 BM463349 CA446766 BM354212
highest scoring ESTs for ZC3H7A:AA885491 AI347278 AK091803 AY163807 BC036857 BC046363 BM469972 BM541920 BQ430708 BU165504 Unigene Cluster for ZC3H7A: Zinc finger CCCH-type containing 7A Hs.371856 [show with all ESTs]Unigene Representative Sequence: NM_014153
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H7A (see all 14
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| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | |
| SP1: | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27a | · | 27b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ZC3H7A
2 Ensembl transcripts including schematic representations: ENST00000396516
ENST00000355758
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Expression for ZC3H7A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZC3H7A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H7A
1 / 2 / 3 7 probe-sets matching ZC3H7A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.371856
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Orthologs for ZC3H7A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for ZC3H7A gene from 5/10 species (see all 10
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About this table Species with no ortholog for ZC3H7A
ENSEMBL Gene Tree for ZC3H7A | Paralogs for ZC3H7A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ZC3H7A gene
- ZC3H7B2
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SNPs/Variants for ZC3H7A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for ZC3H7A (up to first 250kb)
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Disorders & Mutations for ZC3H7A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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Medical News for ZC3H7A(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications for ZC3H7A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for ZC3H7A gene:- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)2, 3, 4 Zhang Q.H....Chen Z. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )4 Aoki H.... Hino O. (2000)
- Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. (PubMed id 18682727)1 Liang J....Fu M. (2008)
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Search for ZC3H7A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing ZC3H7A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
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| Other Databases showing ZC3H7A
(According to HUGE)
About This Section
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Specialized Databases showing ZC3H7A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| About This Section
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| Services for ZC3H7A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for ZC3H7A:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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