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ZC3H6 Gene

protein-coding GIFtS: 44

GC02P112774

zinc finger CCCH-type containing 6
(Previous name: zinc finger CCCH-type domain containing 6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZC3HDC6)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ16526 ^²
FLJ41410 ^¹, ²
FLJ45877 ^¹, ²
KIAA2035 ^¹, ², ³
ZC3HDC6 ^², ³

Descriptions
zinc finger CCCH type domain containing 6 ^²
zinc finger CCCH-type containing 6 ^²
zinc finger CCCH-type domain containing 6 ^¹, ²

External Ids
HGNC: 24762¹
Entrez Gene: 376940²
UniProtKB: P61129³
Ensembl: ENSG00000188177⁷

Search outside databases for aliases for ZC3H6 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZC3H6 gene

Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13

ZC3H6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P112774: (about GC identifiers)

Start:	112,749,642 bp from pter
End:	112,814,111 bp from pter
Size:	64,470 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022135.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZC3H6_HUMAN, P61129 (See protein sequence)

Recommended Name: Zinc finger CCCH domain-containing protein 6

Size: 1189 amino acids; 131671 Da

Sequence caution: Sequence=BAC87128.1; Type=Frameshift; Positions=1120;

REFSEQ proteins: NP_940983.2

ENSEMBL proteins:

ENSP00000386764 ENSP00000340298

Human Recombinant Proteins

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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ZC3H6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZC3H6

Assays for ZC3H6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P61129

ProtoNet protein and cluster: P61129

1 Blocks protein family: IPB000571 Zn-finger

UniProtKB/Swiss-Prot: ZC3H6_HUMAN, P61129

Similarity: Contains 3 C3H1-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZC3H6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_198581

Applied Biosystems Silencer® siRNAs for ZC3H6

Sigma-Aldrich siRNA for ZC3H6

Sigma-Aldrich shRNA for ZC3H6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_198581
Myc/DDK tagged cDNA clone in CMV expression vector: NM_198581
untagged cDNA clones in CMV expression vector (see all 2): NM_198581

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_198581

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZC3H6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZC3H6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_198581

Sigma-Aldrich siRNA for ZC3H6

Sigma-Aldrich shRNA for ZC3H6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_198581

REFSEQ mRNAs for ZC3H6 gene:

NM_198581.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_198581

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_198581
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_198581
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_198581

Additional cDNA sequence:

AB111887.1 AK123404.1 AK127776.1 AK131416.1 AL831901.1 BC155540.1 BC167154.1

6 DOTS entries:

DT.91664316 DT.108516 DT.70105138 DT.435828 DT.100739743 DT.75176505

24/90 AceView cDNA sequences (see all 90 ):

AA825406 AI816829 BE220073 AL831901 AA873249 BX090791 AI471796 AI963731

AI911583 AI733399 BF223587 BX117175 BF437135 AI220781 AI241733 AI697650

AA954607 BX103740 AI088556 AA815218 AA948719 BM979346 AA047728 BE671018

highest scoring ESTs for ZC3H6:

AB111887 AI088556 AI375865 AK123404 AK127776 BU754494 AA047728 AA355614 AA815218 AA825406

Unigene Cluster for ZC3H6:

Zinc finger CCCH-type containing 6

Hs.190477 [show with all ESTs]

Unigene Representative Sequence: NM_198581

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000409871 ENST00000343936

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ZC3H6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H6

¹ / ² / ³

10 probe-sets matching ZC3H6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
68087_at²^{, 3}	U95-D	1	1.00	1.00	0.53	0.75	AA845565	0.60	1.00	0.82	1
75083_at²^{, 3}	U95-E	1	1.00	1.00	0.95	0.82	AI088556	0.80	1.00	0.91	1
76717_at²^{, 3}	U95-D	1	1.00	1.00	0.78	0.86	AI375865	0.80	1.00	0.91	1
53561_at²^{, 3}	U95-B	1	1.00	1.00	0.77	1.00	AI703114	0.60	1.00	0.82	1
73626_f_at²^{, 3}	U95-D	1145	0.94	0.01	0.71	1.78	AA582528	0.20	0.06	0.15	1
86442_at²^{, 3}	U95-E	1	0.31	1.00	0.25	0.80	AI733399	0.40	1.00	0.76	1
241372_at²^{, 3}	U133-B	1	1.00	1.00	--	--	R34135	0.60	1.00	0.82	1
227809_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI703114	0.60	1.00	0.82	1
241372_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227809_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZC3H6 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: ACTTTGGCGA

SOURCE GeneReport for Unigene cluster: Hs.190477

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ZC3H6 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZC3H6¹	--	zinc finger CCCH-type containing 6	91.22(n) 88.85(a)	475751 XM_532959.2 XP_532959.2
chimpanzee (Pan troglodytes)	ZC3H6¹	--	zinc finger CCCH-type containing 6	99.22(n) 98.99(a)	470482 XM_525863.2 XP_525863.2
cow (Bos taurus)	ZC3H6¹	--	zinc finger CCCH-type containing 6	86.72(n) 83.76(a)	506237 XM_582657.3 XP_582657.3
rat (Rattus norvegicus)	Zc3h6¹	--	zinc finger CCCH type containing 6	84.38(n) 77.89(a)	311415 XM_230592.4 XP_230592.4
mouse (Mus musculus)	Zc3h6^{1, 5}	2⁵	zinc finger CCCH type containing 6^{1, 5}	84.17(n)¹ 77.86(a)¹	78751¹ NM_178404.2¹ NP_848491.1¹ AI449423⁵ AK013610⁵ (see all 17)

About this table Species with no ortholog for ZC3H6

ENSEMBL Gene Tree for ZC3H6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZC3H6 gene

ZC3H4² ZC3H8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/306 NCBI SNPs in ZC3H6 are shown (see all 306 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 41)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6761599^1,2	A,C,F,H	112808156(+)	`ACATTG/TGTTGT`	1	--	ut3¹		7		NA EU EA WA	562
	rs6758110^1,2	A,C,F,H	112807811(+)	`CTCCAG/ATGTGT`	1	--	ut3¹ ese³		7		NA EU EA WA	560
	rs6744364^1,2	A,C,F,H	112814170(+)	`ACATAG/TGGGAA`	1	--	ng3¹		4		EU EA WA	418
	rs13387611^1,2	A,C,F,H	112810399(+)	`CACCCT/CGCAAG`	1	--	ut3¹		4		EU EA WA	408
	rs7557862^1,2	A,C,F,H	112808904(+)	`AGAATA/CCATGT`	1	--	ut3¹		6		NA EU EA	428
	rs7591439^1,2	A,C,F,H	112811264(+)	`TCATGA/GTGAAA`	1	--	ut3¹		4		EU EA WA	412
	rs7565648^1,2	F,H	112811165(+)	`CAGCCC/TAAGCA`	1	--	ut3¹		4		EU EA WA	396
--	rs6542048^1,2	A,C	112748683(+)	`cacctG/Taagtc`	1	--	ng5¹		0	--	--	--	--
--	rs12478506^1,2	A	112748035(+)	`AAAAAA/GGGGGC`	1	--	ng5¹		0	--	--	--	--
--	rs7579561^1,2	A	112811392(+)	`gagacA/Ggagtc`	1	--	ut3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for ZC3H6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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5 PubMed articles for ZC3H6 gene:

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)³ Bonaldo M.F....Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 376940	HGNC: 24762	AceView: ZC3HDC6	Ensembl:ENSG00000188177	euGenes: HUgn376940
ECgene: ZC3H6	H-InvDB: ZC3H6

(According to HUGE)
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HUGE: KIAA2035

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZC3H6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ZC3H6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZC3H6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZC3H6		Browse antibodies at Sigma-Aldrich
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ZC3H6 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for ZC3H6

Summaries
for ZC3H6

Genomic Location
for ZC3H6

Proteins
for ZC3H6

Protein Domains/
Families
for ZC3H6

Gene Function
for ZC3H6

Pathways & Interactions
for ZC3H6

Drugs & Compounds
for ZC3H6

Transcripts
for ZC3H6

Expression
for ZC3H6

Orthologs
for ZC3H6

Paralogs
for ZC3H6

SNPs/Variants
for ZC3H6

Disorders & Mutations
for ZC3H6

Medical News
for ZC3H6

Publications
for ZC3H6

Search for ZC3H6

Genome Databases showing ZC3H6

Other Databases showing ZC3H6

Specialized Databases showing ZC3H6

Licensable Technologies
for ZC3H6

Services
for ZC3H6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZC3H6 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor ZC3H6

Summariesfor ZC3H6

Genomic Locationfor ZC3H6

Proteinsfor ZC3H6

Protein Domains/Familiesfor ZC3H6

Gene Functionfor ZC3H6

Pathways & Interactionsfor ZC3H6

Drugs & Compoundsfor ZC3H6

Transcriptsfor ZC3H6

Expression for ZC3H6

Orthologsfor ZC3H6

Paralogsfor ZC3H6

SNPs/Variantsfor ZC3H6

Disorders & Mutationsfor ZC3H6

Medical Newsfor ZC3H6

Publicationsfor ZC3H6

Search for ZC3H6

Genome Databases showing ZC3H6

Other Databases showing ZC3H6

Specialized Databases showing ZC3H6

Licensable Technologiesfor ZC3H6

Servicesfor ZC3H6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZC3H6

Summaries
for ZC3H6

Genomic Location
for ZC3H6

Proteins
for ZC3H6

Protein Domains/
Families
for ZC3H6

Gene Function
for ZC3H6

Pathways & Interactions
for ZC3H6

Drugs & Compounds
for ZC3H6

Transcripts
for ZC3H6

Expression
for ZC3H6

Orthologs
for ZC3H6

Paralogs
for ZC3H6

SNPs/Variants
for ZC3H6

Disorders & Mutations
for ZC3H6

Medical News
for ZC3H6

Publications
for ZC3H6

Licensable Technologies
for ZC3H6

Services
for ZC3H6