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Aliases for ZC3H6 Gene

Aliases for ZC3H6 Gene

  • Zinc Finger CCCH-Type Containing 6 2 3 5
  • Zinc Finger CCCH-Type Domain Containing 6 2 3
  • ZC3HDC6 3 4
  • Zinc Finger CCCH Domain-Containing Protein 6 3
  • KIAA2035 4

External Ids for ZC3H6 Gene

Previous HGNC Symbols for ZC3H6 Gene

  • ZC3HDC6

Previous GeneCards Identifiers for ZC3H6 Gene

  • GC02P112774
  • GC02P113033
  • GC02P105545
  • GC02P112307
  • GC02P112379
  • GC02P112708
  • GC02P112746
  • GC02P112903
  • GC02P113126

Summaries for ZC3H6 Gene

GeneCards Summary for ZC3H6 Gene

ZC3H6 (Zinc Finger CCCH-Type Containing 6) is a Protein Coding gene. An important paralog of this gene is ZC3H4.

Additional gene information for ZC3H6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H6 Gene

Genomics for ZC3H6 Gene

GeneHancer (GH) Regulatory Elements for ZC3H6 Gene

Promoters and enhancers for ZC3H6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I112274 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.7 +0.3 259 2.6 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZC3H6 RGPD8 ANAPC1 POLR1B RPS20P11 NDUFB4P6
GH02I111897 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 19.5 -376.2 -376248 3.8 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SP3 MERTK TMEM87B RGPD8 ZC3H6 ANAPC1 POLR1B FBLN7 RN7SL297P
GH02I112431 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 11.6 +157.5 157468 2.5 ARID4B SIN3A ZNF2 RAD21 ZNF213 THAP11 MIXL1 ZNF654 ZNF362 MXD4 RGPD8 ZC3H6 ENSG00000207383 CHCHD5 ENSG00000243389 GC02M112369
GH02I112792 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +519.2 519208 4.4 HDGF PKNOX1 ARNT ZNF766 CBX5 E2F8 JUNB REST ZNF592 MEF2D IL1B IL1RN ANAPC1 IL1A CKAP2L CBWD2 RGPD8 IL36G ZC3H6 TMEM87B
GH02I113164 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +891.8 891812 5.4 ATF1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 PSD4 RABL2A PAX8-AS1 RGPD8 RNU6-1180P ZC3H6 IL1RN IL1B IL1A IL36B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZC3H6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZC3H6 gene promoter:

Genomic Locations for ZC3H6 Gene

Genomic Locations for ZC3H6 Gene
chr2:112,275,559-112,340,063
(GRCh38/hg38)
Size:
64,505 bases
Orientation:
Plus strand
chr2:113,033,171-113,097,640
(GRCh37/hg19)

Genomic View for ZC3H6 Gene

Genes around ZC3H6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H6 Gene

Proteins for ZC3H6 Gene

  • Protein details for ZC3H6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61129-ZC3H6_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 6
    Protein Accession:
    P61129
    Secondary Accessions:
    • A9JR71
    • Q6ZW96

    Protein attributes for ZC3H6 Gene

    Size:
    1189 amino acids
    Molecular mass:
    131670 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85608.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87128.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87128.1; Type=Frameshift; Positions=1120; Evidence={ECO:0000305};

neXtProt entry for ZC3H6 Gene

Post-translational modifications for ZC3H6 Gene

No Post-translational modifications

Other Protein References for ZC3H6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC3H6 Gene

Domains & Families for ZC3H6 Gene

Gene Families for ZC3H6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZC3H6 Gene

Suggested Antigen Peptide Sequences for ZC3H6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZC3H6: view

No data available for UniProtKB/Swiss-Prot for ZC3H6 Gene

Function for ZC3H6 Gene

Phenotypes From GWAS Catalog for ZC3H6 Gene

Gene Ontology (GO) - Molecular Function for ZC3H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H6: view

Phenotypes for ZC3H6 Gene

genes like me logo Genes that share phenotypes with ZC3H6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H6 Gene

Localization for ZC3H6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H6 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZC3H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with ZC3H6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZC3H6 Gene

Pathways & Interactions for ZC3H6 Gene

SuperPathways for ZC3H6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZC3H6: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H6 Gene

Drugs & Compounds for ZC3H6 Gene

No Compound Related Data Available

Transcripts for ZC3H6 Gene

Unigene Clusters for ZC3H6 Gene

Zinc finger CCCH-type containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H6 Gene

No ASD Table

Relevant External Links for ZC3H6 Gene

GeneLoc Exon Structure for
ZC3H6
ECgene alternative splicing isoforms for
ZC3H6

Expression for ZC3H6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3H6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H6 Gene

This gene is overexpressed in Oral epithelium (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC3H6 Gene



Protein tissue co-expression partners for ZC3H6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZC3H6 Gene:

ZC3H6

SOURCE GeneReport for Unigene cluster for ZC3H6 Gene:

Hs.190477

Evidence on tissue expression from TISSUES for ZC3H6 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZC3H6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H6 Gene

Orthologs for ZC3H6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H6 33 34
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia ZC3H6 33 34
  • 91.08 (n)
cow
(Bos Taurus)
Mammalia ZC3H6 33 34
  • 88.25 (n)
mouse
(Mus musculus)
Mammalia Zc3h6 33 16 34
  • 84.06 (n)
rat
(Rattus norvegicus)
Mammalia Zc3h6 33
  • 83.96 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC3H6 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H6 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H6 33 34
  • 71.32 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h6 33
  • 61.3 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC559312 33
  • 54.35 (n)
ZC3H8 34
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta su(s) 34
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T26A8.4 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4406 34
  • 21 (a)
OneToMany
Species where no ortholog for ZC3H6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZC3H6 Gene

ENSEMBL:
Gene Tree for ZC3H6 (if available)
TreeFam:
Gene Tree for ZC3H6 (if available)

Paralogs for ZC3H6 Gene

Paralogs for ZC3H6 Gene

genes like me logo Genes that share paralogs with ZC3H6: view

Variants for ZC3H6 Gene

Sequence variations from dbSNP and Humsavar for ZC3H6 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000030607 -- 112,334,133(+) C/T 3_prime_UTR_variant
rs1000032458 -- 112,322,138(+) T/C intron_variant
rs1000106904 -- 112,315,705(+) C/T intron_variant
rs1000162154 -- 112,300,691(+) T/G intron_variant
rs1000217529 -- 112,326,962(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H6 Gene

Variant ID Type Subtype PubMed ID
dgv4047n100 CNV loss 25217958
dgv7009n54 CNV gain 21841781
esv2672162 CNV deletion 23128226
esv29391 CNV gain 19812545
esv3357737 CNV duplication 20981092
esv3386218 CNV duplication 20981092
esv3592004 CNV loss 21293372
nsv1149522 OTHER inversion 26484159
nsv521956 CNV loss 19592680
nsv582703 CNV loss 21841781
nsv582707 CNV gain 21841781
nsv819303 CNV gain 19587683
nsv819480 CNV loss 19587683
nsv829621 CNV gain 20364138
nsv963704 CNV duplication 23825009

Variation tolerance for ZC3H6 Gene

Residual Variation Intolerance Score: 8.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZC3H6 Gene

Human Gene Mutation Database (HGMD)
ZC3H6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H6 Gene

Disorders for ZC3H6 Gene

Additional Disease Information for ZC3H6

No disorders were found for ZC3H6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H6 Gene

Publications for ZC3H6 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen CA … Flores-Morales A (The Journal of biological chemistry 2014) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZC3H6 Gene

Sources for ZC3H6 Gene

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