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Aliases for ZC3H6 Gene

Aliases for ZC3H6 Gene

  • Zinc Finger CCCH-Type Containing 6 2 3 5
  • Zinc Finger CCCH-Type Domain Containing 6 2 3
  • ZC3HDC6 3 4
  • Zinc Finger CCCH Domain-Containing Protein 6 3
  • KIAA2035 4

External Ids for ZC3H6 Gene

Previous HGNC Symbols for ZC3H6 Gene

  • ZC3HDC6

Previous GeneCards Identifiers for ZC3H6 Gene

  • GC02P112774
  • GC02P113033
  • GC02P105545
  • GC02P112307
  • GC02P112379
  • GC02P112708
  • GC02P112746
  • GC02P112903

Summaries for ZC3H6 Gene

GeneCards Summary for ZC3H6 Gene

ZC3H6 (Zinc Finger CCCH-Type Containing 6) is a Protein Coding gene. An important paralog of this gene is ZC3H4.

Additional gene information for ZC3H6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H6 Gene

Genomics for ZC3H6 Gene

Regulatory Elements for ZC3H6 Gene

Enhancers for ZC3H6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H111429 1.2 Ensembl dbSUPER 22.7 -843.8 -843759 4.8 HDAC1 PKNOX1 ATF1 FOXA2 ARNT CHAMP1 TCF12 ATF7 CAVIN1 ZBTB2 ANAPC1 RGPD6 ZC3H6 TMEM87B ENSG00000227992 GC02P113411 ENSG00000280878
GH02H111434 1.1 Ensembl dbSUPER 22.7 -835.2 -835159 12 KLF1 ATF1 ETV1 BMI1 PYGO2 ZNF507 RELA YY1 IRF9 ZNF316 ANAPC1 RGPD6 RGPD8 ZC3H6 TMEM87B GC02P113411 ENSG00000280878
GH02H112642 1.7 Ensembl ENCODE dbSUPER 12.8 +370.5 370502 6.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 FLJ42351 ANAPC1 WASH2P ZC3H6 TMEM87B RPS20P11 ENSG00000243389 CHCHD5 ENSG00000207383 POLR1B
GH02H111897 1.1 ENCODE 19.5 -376.2 -376248 3.8 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 TMEM87B RGPD8 MERTK ZC3H6 ANAPC1 POLR1B FBLN7 RN7SL297P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC3H6 on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121923 142 2200 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC

Genomic Locations for ZC3H6 Gene

Genomic Locations for ZC3H6 Gene
64,505 bases
Plus strand

Genomic View for ZC3H6 Gene

Genes around ZC3H6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H6 Gene

Proteins for ZC3H6 Gene

  • Protein details for ZC3H6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCCH domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • A9JR71
    • Q6ZW96

    Protein attributes for ZC3H6 Gene

    1189 amino acids
    Molecular mass:
    131670 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85608.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87128.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87128.1; Type=Frameshift; Positions=1120; Evidence={ECO:0000305};

neXtProt entry for ZC3H6 Gene

Post-translational modifications for ZC3H6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC3H6 Gene

Domains & Families for ZC3H6 Gene

Gene Families for ZC3H6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZC3H6 Gene

Suggested Antigen Peptide Sequences for ZC3H6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZC3H6: view

No data available for UniProtKB/Swiss-Prot for ZC3H6 Gene

Function for ZC3H6 Gene

Gene Ontology (GO) - Molecular Function for ZC3H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H6: view

Phenotypes for ZC3H6 Gene

genes like me logo Genes that share phenotypes with ZC3H6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H6 Gene

Localization for ZC3H6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H6 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZC3H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with ZC3H6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ZC3H6 Gene

Pathways & Interactions for ZC3H6 Gene

SuperPathways for ZC3H6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZC3H6: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H6 Gene

Drugs & Compounds for ZC3H6 Gene

No Compound Related Data Available

Transcripts for ZC3H6 Gene

Unigene Clusters for ZC3H6 Gene

Zinc finger CCCH-type containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H6 Gene

No ASD Table

Relevant External Links for ZC3H6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3H6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H6 Gene

This gene is overexpressed in Oral epithelium (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC3H6 Gene

Protein tissue co-expression partners for ZC3H6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZC3H6 Gene:


SOURCE GeneReport for Unigene cluster for ZC3H6 Gene:


Evidence on tissue expression from TISSUES for ZC3H6 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZC3H6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H6 Gene

Orthologs for ZC3H6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZC3H6 33 34
  • 99.21 (n)
(Canis familiaris)
Mammalia ZC3H6 33 34
  • 91.08 (n)
(Bos Taurus)
Mammalia ZC3H6 33 34
  • 88.25 (n)
(Mus musculus)
Mammalia Zc3h6 33 16 34
  • 84.06 (n)
(Rattus norvegicus)
Mammalia Zc3h6 33
  • 83.96 (n)
(Monodelphis domestica)
Mammalia ZC3H6 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia ZC3H6 34
  • 67 (a)
(Gallus gallus)
Aves ZC3H6 33 34
  • 71.32 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h6 33
  • 61.3 (n)
(Danio rerio)
Actinopterygii LOC559312 33
  • 54.35 (n)
ZC3H8 34
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta su(s) 34
  • 10 (a)
(Caenorhabditis elegans)
Secernentea T26A8.4 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4406 34
  • 21 (a)
Species where no ortholog for ZC3H6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZC3H6 Gene

Gene Tree for ZC3H6 (if available)
Gene Tree for ZC3H6 (if available)

Paralogs for ZC3H6 Gene

Paralogs for ZC3H6 Gene

genes like me logo Genes that share paralogs with ZC3H6: view

Variants for ZC3H6 Gene

Sequence variations from dbSNP and Humsavar for ZC3H6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000030607 -- 112,334,133(+) GATAA(C/T)ATTTT utr-variant-3-prime
rs1000032458 -- 112,322,138(+) CTCCT(C/T)CCCTC intron-variant
rs1000106904 -- 112,315,705(+) ATTCT(C/T)GTGCC intron-variant
rs1000162154 -- 112,300,691(+) AACCT(G/T)TATGC intron-variant
rs1000217529 -- 112,326,962(+) TTGTG(A/C)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H6 Gene

Variant ID Type Subtype PubMed ID
nsv963704 CNV duplication 23825009
nsv829621 CNV gain 20364138
nsv819480 CNV loss 19587683
nsv819303 CNV gain 19587683
nsv582707 CNV gain 21841781
nsv582703 CNV loss 21841781
nsv521956 CNV loss 19592680
nsv1149522 OTHER inversion 26484159
esv3592004 CNV loss 21293372
esv3386218 CNV duplication 20981092
esv3357737 CNV duplication 20981092
esv29391 CNV gain 19812545
esv2672162 CNV deletion 23128226
dgv7009n54 CNV gain 21841781
dgv4047n100 CNV loss 25217958

Variation tolerance for ZC3H6 Gene

Residual Variation Intolerance Score: 8.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H6 Gene

Disorders for ZC3H6 Gene

Relevant External Links for ZC3H6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZC3H6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H6 Gene

Publications for ZC3H6 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen CA … Flores-Morales A (The Journal of biological chemistry 2014) 3 60
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for ZC3H6 Gene

Sources for ZC3H6 Gene

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