ZC3H4 Gene
protein-coding GIFtS: 44
GCID: GC19M047569
|
|
zinc finger CCCH-type containing 4(Previous name: chromosome 19 open reading frame 7 )
(Previous symbol: C19orf7)
| |
Aliases
for ZC3H4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger CCCH-Type Containing 41 2 | | C19orf71 2 3 | | KIAA10641 3 | | Chromosome 19 Open Reading Frame 71 | | Zinc Finger CCCH Domain-Containing Protein 42 |
Export aliases for ZC3H4 gene to outside databasesPrevious GC identifers: GC19M052260 GC19M043991 |
Summaries
for ZC3H4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZC3H4:
This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. Thesezinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and onehistidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptionalregulation. (provided by RefSeq, Aug 2011)
|
Genomic Views
for ZC3H4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZC3H4 gene promoter:
Egr-3 C/EBPbeta Sp1 Egr-1 CUTL1 Nkx2-5 GATA-1 Evi-1 Egr-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZC3H4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.33ZC3H4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M047569: view genomic region
(about GC identifiers)
Start:
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47,567,444 bp from pter |
End:
|
47,617,009 bp from pter |
Size:
|
49,566 bases |
Orientation:
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minus strand |
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Proteins
for ZC3H4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZC3H4_HUMAN, Q9UPT8 (See
protein sequence)Recommended Name: Zinc finger CCCH domain-containing protein 4 Size: 1303 amino acids; 140257 Da
Sequence caution: Sequence=BAA83016.2; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for ZC3H4:2CQE (3D)
Secondary accessions: Q9Y420Explore the universe of human proteins at neXtProt for ZC3H4: NX_Q9UPT8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UPT8
ZC3H4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055983.1
ENSEMBL proteins: ENSP00000253048
Human Recombinant Protein Products:
ZC3H4 Antibody Products:
Assay Products for ZC3H4: |
Protein
Domains /
Families
for ZC3H4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZC3H4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UPT8ProtoNet protein and cluster: Q9UPT8 1 Blocks protein family: IPB000571 Zn-finger
UniProtKB/Swiss-Prot: ZC3H4_HUMAN, Q9UPT8Similarity: Contains 3 C3H1-type zinc fingers |
Function
for ZC3H4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZC3H4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZC3H4:
Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Zc3h4):
ZC3H4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ZC3H4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3H4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for ZC3H4 (Q9UPT83 ENSP000002530484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZC3H4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZC3H4
Search CenterWatch for drugs/clinical trials and news about ZC3H4
|
Transcripts
for ZC3H4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZC3H4 gene: NM_015168.1 Unigene Cluster for ZC3H4: Zinc finger CCCH-type containing 4 Hs.104661 [show with all ESTs]Unigene Representative Sequence: NM_0151681 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000253048(uc002pga.4 uc002pgb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZC3H4 (NM_015168) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZC3H4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZC3H4 |
Additional cDNA sequence: AB028987.2 AK074282.1 AK125279.1 AL050155.1 X58238.1 7 DOTS entries: DT.111757 DT.111756 DT.97763762 DT.95301348 DT.97810776 DT.101968338 DT.121498614 24/66 AceView cDNA sequences (see all 66): AA812040 AW304020 C02391 AA570468 AL050155 AI370240 AA781792 AB028987 BE543060 AI760394 BU674533 AI762720 AK125279 CB136024 AA456182 AI690086 BQ669599 CD251918 AA340627 AA907309 BQ675264 AW009235 BM676612 BM714232
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZC3H4
|
Expression
for ZC3H4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZC3H4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTATTTCAC
About this image
See ZC3H4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZC3H4
SOURCE GeneReport for Unigene cluster: Hs.104661
SABiosciences Custom PCR Arrays for ZC3H4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZC3H4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZC3H4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC3H4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC3H4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H4 |
Orthologs
for ZC3H4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZC3H4 gene from 8/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Zc3h41 , 5 |
zinc finger CCCH-type containing 41, 5 |
85.89(n)1
92.33(a)1 |
|
7 (9.03 cM)5
3304741 NM_198631.21 NP_941033.21
164011965 |
lizard
(Anolis carolinensis) |
Reptilia |
ZC3H46 |
-- |
69(a) |
1 ↔ 1 |
LGf(1771452-1784033) |
African clawed frog
(Xenopus laevis) |
Amphibia |
CD329910.12 |
-- |
80.27(n) |
|
CD329910.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5578231 |
uncharacterized LOC557823 |
60.6(n)
60.79(a) |
|
557823 XM_680968.5 XP_686060.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
su(s)6 |
suppressor of sable |
12(a) |
1 → many |
X(529920-537793) |
worm
(Caenorhabditis elegans) |
Secernentea |
CELE_T26A8.41 |
Protein T26A8.4 |
44.27(n)
34.73(a) |
|
177643 NM_069034.4 NP_501435.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
emb17896 |
zinc finger CCCH domain-containing protein 65 |
12(a) |
1 → many |
5(23027892-23030565) |
rice
(Oryza sativa) |
Liliopsida |
-- |
zinc finger C-x8-C-x5-C-x3-H type family protein, ... |
12(a) |
1 → many |
1(21972642-21979437) |
ENSEMBL Gene Tree for ZC3H4 (if available)
TreeFam Gene Tree for ZC3H4 (if available) |
Paralogs
for ZC3H4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZC3H4 gene
- ZC3H62 ZC3H82
2 SIMAP similar genes for ZC3H4 using alignment to 2 protein entries: ZC3H4_HUMAN (see all proteins):LOC84524 ZC3H8
ZC3H4 for paralogs About GeneDecksing
|
Genomic Variants
for ZC3H4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZC3H4 (47567444 - 47617009 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZC3H4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC3H4 |
|
Disorders
/ Diseases
for ZC3H4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZC3H4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZC3H4 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with ZC3H4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
|
External Searches for ZC3H4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZC3H4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZC3H4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZC3H4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZC3H4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZC3H4 gene:
Search GeneIP for patents involving ZC3H4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZC3H4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZC3H4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZC3H4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZC3H4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZC3H4 | | OriGene 3'-UTR Clone for ZC3H4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 | | | ZC3H4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H4 |
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