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Aliases for ZC3H4 Gene

Aliases for ZC3H4 Gene

  • Zinc Finger CCCH-Type Containing 4 2 3
  • C19orf7 3 4
  • Chromosome 19 Open Reading Frame 7 2
  • KIAA1064 4

External Ids for ZC3H4 Gene

Previous HGNC Symbols for ZC3H4 Gene

  • C19orf7

Previous GeneCards Identifiers for ZC3H4 Gene

  • GC19M052260
  • GC19M047569
  • GC19M043991

Summaries for ZC3H4 Gene

Entrez Gene Summary for ZC3H4 Gene

  • This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZC3H4 Gene

ZC3H4 (Zinc Finger CCCH-Type Containing 4) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is ZC3H6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H4 Gene

Genomics for ZC3H4 Gene

Regulatory Elements for ZC3H4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZC3H4 Gene

47,064,187 bp from pter
47,113,752 bp from pter
49,566 bases
Minus strand

Genomic View for ZC3H4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZC3H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H4 Gene

Proteins for ZC3H4 Gene

  • Protein details for ZC3H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCCH domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q9Y420

    Protein attributes for ZC3H4 Gene

    1303 amino acids
    Molecular mass:
    140257 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA83016.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZC3H4 Gene

neXtProt entry for ZC3H4 Gene

Proteomics data for ZC3H4 Gene at MOPED

Post-translational modifications for ZC3H4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC3H4 Gene

Domains & Families for ZC3H4 Gene

Gene Families for ZC3H4 Gene

Protein Domains for ZC3H4 Gene


Suggested Antigen Peptide Sequences for ZC3H4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 C3H1-type zinc fingers.
  • Contains 3 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZC3H4: view

Function for ZC3H4 Gene

Gene Ontology (GO) - Molecular Function for ZC3H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H4: view

Phenotypes for ZC3H4 Gene

genes like me logo Genes that share phenotypes with ZC3H4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC3H4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H4 Gene

Localization for ZC3H4 Gene

Subcellular locations from

Jensen Localization Image for ZC3H4 Gene COMPARTMENTS Subcellular localization image for ZC3H4 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZC3H4 Gene

Pathways & Interactions for ZC3H4 Gene

SuperPathways for ZC3H4 Gene

No Data Available

Interacting Proteins for ZC3H4 Gene

Gene Ontology (GO) - Biological Process for ZC3H4 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZC3H4 Gene

Drugs & Compounds for ZC3H4 Gene

No Compound Related Data Available

Transcripts for ZC3H4 Gene

Unigene Clusters for ZC3H4 Gene

Zinc finger CCCH-type containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC3H4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - - -
SP4: -

Relevant External Links for ZC3H4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H4 Gene

mRNA expression in normal human tissues for ZC3H4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.1), Lung (8.6), and CD8 Tcells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3H4 Gene

SOURCE GeneReport for Unigene cluster for ZC3H4 Gene Hs.104661

genes like me logo Genes that share expression patterns with ZC3H4: view

Protein tissue co-expression partners for ZC3H4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H4 Gene

Orthologs for ZC3H4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZC3H4 35
  • 88.52 (n)
  • 92.5 (a)
ZC3H4 36
  • 93 (a)
(Canis familiaris)
Mammalia ZC3H4 35
  • 88.48 (n)
  • 92.85 (a)
ZC3H4 36
  • 93 (a)
(Mus musculus)
Mammalia Zc3h4 35
  • 85.1 (n)
  • 90.69 (a)
Zc3h4 16
Zc3h4 36
  • 91 (a)
(Pan troglodytes)
Mammalia ZC3H4 35
  • 99.15 (n)
  • 99.44 (a)
ZC3H4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zc3h4 35
  • 83.33 (n)
  • 87.31 (a)
(Monodelphis domestica)
Mammalia ZC3H4 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ZC3H4 36
  • 60 (a)
(Anolis carolinensis)
Reptilia ZC3H4 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145628 35
  • 63.81 (n)
  • 64.44 (a)
Str.7732 35
(Danio rerio)
Actinopterygii zc3h4 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta su(s) 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea T26A8.4 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4406 36
  • 20 (a)
Species with no ortholog for ZC3H4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZC3H4 Gene

Gene Tree for ZC3H4 (if available)
Gene Tree for ZC3H4 (if available)

Paralogs for ZC3H4 Gene

Paralogs for ZC3H4 Gene

(2) SIMAP similar genes for ZC3H4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZC3H4: view

Variants for ZC3H4 Gene

Sequence variations from dbSNP and Humsavar for ZC3H4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs182550 -- 47,085,802(+) CTCTA(G/T)AGGAC intron-variant
rs186316 -- 47,086,266(+) CCCTT(C/T)CTTCA intron-variant
rs192823 -- 47,085,675(+) GGGCA(C/G)TGGAC intron-variant
rs192824 - 47,086,395(+) CTCTT(C/T)CTCGT missense, reference
rs192825 -- 47,093,209(+) agact(C/T)tgcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H4 Gene

Variant ID Type Subtype PubMed ID
nsv2512 CNV Insertion 18451855
dgv3962n71 CNV Loss 21882294
nsv833851 CNV Loss 17160897

Variation tolerance for ZC3H4 Gene

Residual Variation Intolerance Score: 10.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.08; 68.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H4 Gene

Disorders for ZC3H4 Gene

Relevant External Links for ZC3H4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZC3H4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H4 Gene

Publications for ZC3H4 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  4. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. (PMID: 24861553) Wen W. … Tanaka T. (Hum. Mol. Genet. 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for ZC3H4 Gene

Sources for ZC3H4 Gene

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