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ZC3H4 Gene

protein-coding GIFtS: 43

GC19M052260

zinc finger CCCH-type containing 4
(Previous name: chromosome 19 open reading frame 7 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C19orf7)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C19orf7 ^², ³
KIAA1064 ^¹, ², ³

Descriptions
chromosome 19 open reading frame 7 ^¹
zinc finger CCCH-type containing 4 ^²

External Ids
HGNC: 17808¹
Entrez Gene: 23211²
UniProtKB: Q9UPT8³
Ensembl: ENSG00000130749⁷

Search outside databases for aliases for ZC3H4 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.33

ZC3H4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M052260: (about GC identifiers)

Start:	52,259,284 bp from pter
End:	52,308,849 bp from pter
Size:	49,566 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZC3H4_HUMAN, Q9UPT8 (See protein sequence)

Recommended Name: Zinc finger CCCH domain-containing protein 4

Size: 1303 amino acids; 140257 Da

PDB structures from and Proteopedia :

2CQE (3D)

Secondary accessions: Q9Y420

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055983.1

ENSEMBL proteins:

ENSP00000253048

Human Recombinant Proteins

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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ZC3H4:

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Assays for ZC3H4:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UPT8

ProtoNet protein and cluster: Q9UPT8

1 Blocks protein family: IPB000571 Zn-finger

UniProtKB/Swiss-Prot: ZC3H4_HUMAN, Q9UPT8

Similarity: Contains 3 C3H1-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Applied Biosystems Silencer® siRNAs for ZC3H4

Sigma-Aldrich siRNA for ZC3H4

Sigma-Aldrich shRNA for ZC3H4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015168
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015168
untagged cDNA clone in CMV expression vector: NM_015168

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015168

1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Zc3h4):

growth/size

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZC3H4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Sigma-Aldrich siRNA for ZC3H4

Sigma-Aldrich shRNA for ZC3H4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015168

REFSEQ mRNAs for ZC3H4 gene:

NM_015168.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015168

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015168
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015168
                                 untagged cDNA clone in CMV expression vector: NM_015168

Additional cDNA sequence:

AB028987.2 AK074282.1 AK125279.1 AL050155.1 X58238.1

7 DOTS entries:

DT.111757 DT.111756 DT.97763762 DT.95301348 DT.97810776 DT.121498614 DT.101968338

24/66 AceView cDNA sequences (see all 66 ):

AA570468 AA812040 AL050155 AA781792 AI762720 BE543060 AW304020 AK125279

C02391 BU674533 AI370240 AB028987 AI760394 AA311988 BM714232 BQ271094

AW403108 AI053619 AA157307 AK074282 CD251918 AA907309 BM819005 BQ187423

Unigene Cluster for ZC3H4:

Zinc finger CCCH-type containing 4

Hs.104661 [show with all ESTs]

Unigene Representative Sequence: NM_015168

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H4

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	·	13c
SP1:			-														-		-		-		-		-		-		-
SP2:
SP3:
SP4:																									-
SP5:

About this scheme

ECgene alternative splicing isoforms for ZC3H4

1 Ensembl transcript including schematic representation:

ENST00000253048

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZC3H4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H4

¹ / ²

3 probe-sets matching ZC3H4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36860_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
213390_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
213390_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTATTTCAC

SOURCE GeneReport for Unigene cluster: Hs.104661

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZC3H4 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ZC3H4¹	--	zinc finger CCCH-type containing 4	93.62(n) 92.72(a)	468930 XM_524315.2 XP_524315.2
cow (Bos taurus)	ZC3H4¹	--	zinc finger CCCH-type containing 4	89.08(n) 93.23(a)	521686 XM_599954.3 XP_599954.3
rat (Rattus norvegicus)	LOC678741¹	--	similar to Zinc finger CCCH-type domain containing more	85.75(n) 91.71(a)	678741 XM_001053214.1 XP_001053214.1
mouse (Mus musculus)	Zc3h4⁵	7 (6.30 cM)	zinc finger CCCH-type containing 4	--	CN667093
zebrafish (Danio rerio)	LOC557823¹	--	similar to zinc finger CCCH-type containing 4	60.73(n) 60.87(a)	557823 XM_680968.3 XP_686060.3

About this table Species with no ortholog for ZC3H4

ENSEMBL Gene Tree for ZC3H4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZC3H4 gene

ZC3H6² ZC3H8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/219 NCBI SNPs in ZC3H4 are shown (see all 219 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 70)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3810291^1,2	A,C,F,H	52260843(+)	`CATGCG/ACCAGG`	1	--	ut3¹ ese³		5	EA EU WA	1682
	rs192824^1,2	C,F,H	52281492(+)	`CTCTTC/TCTCGT`	1	E/K	mis¹ trp³		5	MN EU EA WA	588
	rs309195^1,2	C,F,H	52261682(+)	`CGGGGG/CCTGCA`	1	G/A	mis¹ ese³		9	MN EU EA WA	1022
	rs7247643^1,2	F,H	52309865(+)	`GTCAAC/GAGTGA`	1	--	ng3¹		4	EU EA WA	420
	rs10405289^1,2	F,H	52309913(+)	`ATATTG/CATCCT`	1	--	ng3¹		4	EU EA WA	418
	rs8111597^1,2	F,H	52260892(+)	`CCTTTT/ACACTC`	1	--	ut3¹ ese³		4	EU EA WA	412
	rs11669142^1,2	F,H	52308955(+)	`TAGTCC/ACTCAG`	1	--	ng3¹		4	EU EA WA	418
--	rs381976^1,2	H	52267085(+)	`GTCTGC/GGTGCA`	1	A/P	mis¹ ese³		5	MN EU EA WA	586
	rs436187^1,2	H	52260361(+)	`AACACC/GTGCAT`	1	--	ut3¹ ese³		5	MN EU EA WA	592
	rs402833^1,2	H	52276660(-)	`ACTGCA/GTGTGT`	1	M/V	mis¹ ese³		4	EU EA WA	404

About this table

HapMap Linkage Disequilibrium images for ZC3H4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/11 PubMed articles for ZC3H4 gene (see all 11 ):

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{3, 4} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{3, 4} Kikuno R....Ohara O. (1999)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)⁴ Matsuoka S.... Elledge S.J. (2007)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23211	HGNC: 17808	AceView: C19orf7	Ensembl:ENSG00000130749	euGenes: HUgn23211
ECgene: ZC3H4	H-InvDB: ZC3H4

(According to HUGE)
About This Section

HUGE: KIAA1064

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZC3H4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ZC3H4:

TaqMan ® Gene Expression Assays

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Free SNP selection tool

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ZC3H4 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for ZC3H4

Summaries
for ZC3H4

Genomic Location
for ZC3H4

Proteins
for ZC3H4

Protein Domains/
Families
for ZC3H4

Gene Function
for ZC3H4

Pathways & Interactions
for ZC3H4

Drugs & Compounds
for ZC3H4

Transcripts
for ZC3H4

Expression
for ZC3H4

Orthologs
for ZC3H4

Paralogs
for ZC3H4

SNPs/Variants
for ZC3H4

Disorders & Mutations
for ZC3H4

Medical News
for ZC3H4

Publications
for ZC3H4

Search for ZC3H4

Genome Databases showing ZC3H4

Other Databases showing ZC3H4

Specialized Databases showing ZC3H4

Licensable Technologies
for ZC3H4

Services
for ZC3H4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZC3H4 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor ZC3H4

Summariesfor ZC3H4

Genomic Locationfor ZC3H4

Proteinsfor ZC3H4

Protein Domains/Familiesfor ZC3H4

Gene Functionfor ZC3H4

Pathways & Interactionsfor ZC3H4

Drugs & Compoundsfor ZC3H4

Transcriptsfor ZC3H4

Expression for ZC3H4

Orthologsfor ZC3H4

Paralogsfor ZC3H4

SNPs/Variantsfor ZC3H4

Disorders & Mutationsfor ZC3H4

Medical Newsfor ZC3H4

Publicationsfor ZC3H4

Search for ZC3H4

Genome Databases showing ZC3H4

Other Databases showing ZC3H4

Specialized Databases showing ZC3H4

Licensable Technologiesfor ZC3H4

Servicesfor ZC3H4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZC3H4

Summaries
for ZC3H4

Genomic Location
for ZC3H4

Proteins
for ZC3H4

Protein Domains/
Families
for ZC3H4

Gene Function
for ZC3H4

Pathways & Interactions
for ZC3H4

Drugs & Compounds
for ZC3H4

Transcripts
for ZC3H4

Expression
for ZC3H4

Orthologs
for ZC3H4

Paralogs
for ZC3H4

SNPs/Variants
for ZC3H4

Disorders & Mutations
for ZC3H4

Medical News
for ZC3H4

Publications
for ZC3H4

Licensable Technologies
for ZC3H4

Services
for ZC3H4