ZC3H3 Gene
protein-coding GIFtS: 45
GCID: GC08M144519
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zinc finger CCCH-type containing 3(Previous name: zinc finger CCCH-type domain containing 3 )
(Previous symbol: ZC3HDC3)
| |
Aliases
for ZC3H3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger CCCH-Type Containing 31 2 | | ZC3HDC31 2 3 | | Zinc Finger CCCH-Type Domain Containing 31 2 | | KIAA01501 3 | | Zinc Finger CCCH Domain-Containing Protein 32 | | Zinc Finger CCCH Type Domain Containing 32 |
Export aliases for ZC3H3 gene to outside databasesPrevious GC identifers: GC08M144591 GC08M139772 |
Summaries
for ZC3H3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZC3H3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZC3H3 gene promoter:
HOXA9B HOXA9 LHX3b/Lhx3b HTF GATA-1 Chx10 LHX3a/Lhx3a Cart-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZC3H3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3ZC3H3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M144519: view genomic region
(about GC identifiers)
Start:
|
144,519,825 bp from pter |
End:
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144,623,623 bp from pter |
Size:
|
103,799 bases |
Orientation:
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minus strand |
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Proteins
for ZC3H3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZC3H3_HUMAN, Q8IXZ2 (See
protein sequence)Recommended Name: Zinc finger CCCH domain-containing protein 3 Size: 948 amino acids; 101941 Da
Secondary accessions: Q14163 Q8N4E2 Q9BUS4Alternative splicing: 2 isoforms: Q8IXZ2-1 Q8IXZ2-2 Explore the universe of human proteins at neXtProt for ZC3H3: NX_Q8IXZ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IXZ2
ZC3H3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055932.2
ENSEMBL proteins: ENSP00000262577 ENSP00000436834
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ZC3H3 for ontologies About GeneDecksing
ZC3H3 Antibody Products:
Assay Products for ZC3H3: |
Protein
Domains /
Families
for ZC3H3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZC3H3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IXZ2ProtoNet protein and cluster: Q8IXZ2 1 Blocks protein family: IPB000571 Zn-finger
UniProtKB/Swiss-Prot: ZC3H3_HUMAN, Q8IXZ2Similarity: Contains 5 C3H1-type zinc fingers |
Function
for ZC3H3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZC3H3 (NM_015117) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZC3H3 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZC3H3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3H3
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
ZC3H3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZC3H3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZC3H3
Search CenterWatch for drugs/clinical trials and news about ZC3H3
|
Transcripts
for ZC3H3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZC3H3 gene: NM_015117.2 Unigene Cluster for ZC3H3: Zinc finger CCCH-type containing 3 Hs.521915 [show with all ESTs]Unigene Representative Sequence: NM_0151172 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262577(uc003yyd.2) ENST00000528401
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZC3H3 (NM_015117) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZC3H3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H3 |
Additional cDNA sequence: BC038670.1 D63484.1 7 DOTS entries: DT.442780 DT.75100207 DT.100009916 DT.100803446 DT.120636026 DT.97839896 DT.95273917 24/98 AceView cDNA sequences (see all 98): D63484 AI917334 BX341764 CK903970 AW135082 BX279623 BM053056 BM148116 BG760659 BI554154 BE386102 BQ671910 BQ672330 AL079951 NM_015117 BG469217 AI081066 BM810616 AW024134 BU166511 AW731912 BQ945268 BE410183 BU149081
GeneLoc Exon Structure
|
Expression
for ZC3H3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZC3H3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCAGCGTGT
About this image
See ZC3H3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZC3H3
SOURCE GeneReport for Unigene cluster: Hs.521915
SABiosciences Custom PCR Arrays for ZC3H3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZC3H3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZC3H3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC3H3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC3H3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H3 |
Orthologs
for ZC3H3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZC3H3 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Zc3h31 , 5 |
zinc finger CCCH type containing 31, 5 |
77.17(n)1
71.37(a)1 |
|
15 (34.84 cM)5
2236421 NM_172121.11 NP_742119.11
757544475 |
chicken
(Gallus gallus) |
Aves |
ZC3H31 |
zinc finger CCCH-type containing 3 |
56.85(n)
51.14(a) |
|
430349 NM_001031585.1 NP_001026756.1 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.11642 |
Transcribed sequence with weak similarity to protein more |
79.92(n) |
|
142028447 |
zebrafish
(Danio rerio) |
Actinopterygii |
zc3h31 |
zinc finger CCCH-type containing 3 |
45.84(n)
40.33(a) |
|
561182 XM_684588.5 XP_689680.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ZC3H36 |
ZC3H3 |
16(a) |
1 ↔ 1 |
3L(8500569-8502863) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G215806 |
zinc finger CCCH domain-containing protein |
7(a) |
1 ↔ 1 |
1(7557262-7565803) |
ENSEMBL Gene Tree for ZC3H3 (if available)
TreeFam Gene Tree for ZC3H3 (if available) |
Paralogs
for ZC3H3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZC3H3 gene
- CPSF4L2 CPSF42
ZC3H3 for paralogs About GeneDecksing
|
Genomic Variants
for ZC3H3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZC3H3 (144519825 - 144623623 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for ZC3H3
10 CNVs: 23289 30299 52421 100540 30298 52423 30300 53408 52422 30301
Human Gene Mutation Database (HGMD): ZC3H3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC3H3 |
|
Disorders
/ Diseases
for ZC3H3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZC3H3 for disorders About MalaCards
ZC3H3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZC3H3 (2 documents)
Export disorders for ZC3H3 gene to outside databases
|
Publications
for ZC3H3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZC3H3 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZC3H3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T....Nomura N. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
- Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
- A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export. (PubMed id 19364924)1 Hurt J.A....Silver P.A. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
|
External Searches for ZC3H3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZC3H3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZC3H3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZC3H3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZC3H3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZC3H3 gene:
Search GeneIP for patents involving ZC3H3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZC3H3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZC3H3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZC3H3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZC3H3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZC3H3 | | OriGene 3'-UTR Clone for ZC3H3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZC3H3 | | OriGene Custom Protein Services for ZC3H3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZC3H3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC3H3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZC3H3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC3H3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC3H3 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZC3H3 |
| |  |  |  |  | | | | |
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 | | | ZC3H3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H3 |
|  |  |  | | | | ThermoFisher Antibodies for ZC3H3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H3 |
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