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Aliases for ZC3H3 Gene

Aliases for ZC3H3 Gene

  • Zinc Finger CCCH-Type Containing 3 2 3 5
  • Zinc Finger CCCH-Type Domain Containing 3 2 3
  • Smad-Interacting CPSF-Like Factor 3 4
  • ZC3HDC3 3 4
  • Zinc Finger CCCH Type Domain Containing 3 3
  • KIAA0150 4
  • SMICL 4

External Ids for ZC3H3 Gene

Previous HGNC Symbols for ZC3H3 Gene

  • ZC3HDC3

Previous GeneCards Identifiers for ZC3H3 Gene

  • GC08M144591
  • GC08M144519
  • GC08M139772

Summaries for ZC3H3 Gene

GeneCards Summary for ZC3H3 Gene

ZC3H3 (Zinc Finger CCCH-Type Containing 3) is a Protein Coding gene. An important paralog of this gene is CPSF4.

UniProtKB/Swiss-Prot for ZC3H3 Gene

  • Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H3 Gene

Genomics for ZC3H3 Gene

Regulatory Elements for ZC3H3 Gene

Promoters for ZC3H3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZC3H3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC3H3 Gene

Chromosome:
8
Start:
143,437,655 bp from pter
End:
143,542,245 bp from pter
Size:
104,591 bases
Orientation:
Minus strand

Genomic View for ZC3H3 Gene

Genes around ZC3H3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H3 Gene

Proteins for ZC3H3 Gene

  • Protein details for ZC3H3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXZ2-ZC3H3_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 3
    Protein Accession:
    Q8IXZ2
    Secondary Accessions:
    • Q14163
    • Q8N4E2
    • Q9BUS4

    Protein attributes for ZC3H3 Gene

    Size:
    948 amino acids
    Molecular mass:
    101941 Da
    Quaternary structure:
    • Interacts with SMAD1, SMAD3, SMAD4, CPSF2 and CPSF3 (By similarity).

    Alternative splice isoforms for ZC3H3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H3 Gene

Proteomics data for ZC3H3 Gene at MOPED

Post-translational modifications for ZC3H3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC3H3 Gene

Domains & Families for ZC3H3 Gene

Gene Families for ZC3H3 Gene

Protein Domains for ZC3H3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC3H3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXZ2

UniProtKB/Swiss-Prot:

ZC3H3_HUMAN :
  • Contains 5 C3H1-type zinc fingers.
Similarity:
  • Contains 5 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZC3H3: view

Function for ZC3H3 Gene

Molecular function for ZC3H3 Gene

UniProtKB/Swiss-Prot Function:
Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity).

Gene Ontology (GO) - Molecular Function for ZC3H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZC3H3: view

Phenotypes for ZC3H3 Gene

GenomeRNAi human phenotypes for ZC3H3:
genes like me logo Genes that share phenotypes with ZC3H3: view

Animal Model Products

miRNA for ZC3H3 Gene

miRTarBase miRNAs that target ZC3H3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H3 Gene

Localization for ZC3H3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H3 Gene COMPARTMENTS Subcellular localization image for ZC3H3 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for ZC3H3 Gene

Pathways & Interactions for ZC3H3 Gene

SuperPathways for ZC3H3 Gene

No Data Available

Interacting Proteins for ZC3H3 Gene

Gene Ontology (GO) - Biological Process for ZC3H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IMP 19364924
GO:0010793 regulation of mRNA export from nucleus IMP 19364924
genes like me logo Genes that share ontologies with ZC3H3: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H3 Gene

Drugs & Compounds for ZC3H3 Gene

No Compound Related Data Available

Transcripts for ZC3H3 Gene

mRNA/cDNA for ZC3H3 Gene

Unigene Clusters for ZC3H3 Gene

Zinc finger CCCH-type containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H3 Gene

No ASD Table

Relevant External Links for ZC3H3 Gene

GeneLoc Exon Structure for
ZC3H3
ECgene alternative splicing isoforms for
ZC3H3

Expression for ZC3H3 Gene

mRNA expression in normal human tissues for ZC3H3 Gene

mRNA differential expression in normal tissues according to GTEx for ZC3H3 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for ZC3H3 Gene

This gene is overexpressed in Serum (52.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3H3 Gene



SOURCE GeneReport for Unigene cluster for ZC3H3 Gene Hs.521915

genes like me logo Genes that share expression patterns with ZC3H3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZC3H3 Gene

Orthologs for ZC3H3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZC3H3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZC3H3 35
  • 79.8 (n)
  • 72.44 (a)
ZC3H3 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H3 35
  • 80.81 (n)
  • 76 (a)
ZC3H3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc3h3 35
  • 77.02 (n)
  • 71.37 (a)
Zc3h3 16
Gm7353 36
  • 70 (a)
OneToMany
Zc3h3 36
  • 70 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZC3H3 35
  • 98.66 (n)
  • 97.78 (a)
ZC3H3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3h3 35
  • 76.55 (n)
  • 70.87 (a)
oppossum
(Monodelphis domestica)
Mammalia ZC3H3 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H3 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H3 35
  • 58.06 (n)
  • 52.04 (a)
ZC3H3 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1164 35
zc3h3 35
  • 55.82 (n)
  • 50.85 (a)
zebrafish
(Danio rerio)
Actinopterygii zc3h3 35
  • 46.73 (n)
  • 41.11 (a)
zc3h3 36
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ZC3H3 36
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTH1 36
  • 25 (a)
OneToMany
Species with no ortholog for ZC3H3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H3 Gene

ENSEMBL:
Gene Tree for ZC3H3 (if available)
TreeFam:
Gene Tree for ZC3H3 (if available)

Paralogs for ZC3H3 Gene

Paralogs for ZC3H3 Gene

genes like me logo Genes that share paralogs with ZC3H3: view

Variants for ZC3H3 Gene

Sequence variations from dbSNP and Humsavar for ZC3H3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_018457 -
rs3750206 - 143,538,921(-) AGAAT(A/T)TGAGG nc-transcript-variant, reference, missense
rs3750207 - 143,538,914(-) GAGGA(A/C)ACCCC nc-transcript-variant, reference, missense
rs1318196 - 143,538,172(-) AGGCC(A/G)GCAGC nc-transcript-variant, reference, missense
rs4874147 - 143,538,013(+) GCTGC(C/T)GCGTC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZC3H3 Gene

Variant ID Type Subtype PubMed ID
dgv7920n71 CNV Loss 21882294
nsv891671 CNV Loss 21882294
nsv470247 CNV Loss 18288195
nsv891674 CNV Loss 21882294
nsv891676 CNV Loss 21882294
dgv7924n71 CNV Loss 21882294
dgv7925n71 CNV Loss 21882294
nsv891682 CNV Loss 21882294
dgv7926n71 CNV Loss 21882294
nsv891687 CNV Loss 21882294
dgv7927n71 CNV Loss 21882294
dgv7928n71 CNV Loss 21882294
dgv7929n71 CNV Loss 21882294
nsv891696 CNV Loss 21882294
nsv831487 CNV Gain 17160897
dgv7930n71 CNV Loss 21882294
nsv824766 CNV Gain 20364138
esv2673374 CNV Deletion 23128226
esv2738014 CNV Deletion 23290073
esv1091073 CNV Deletion 17803354
dgv7931n71 CNV Loss 21882294
dgv7932n71 CNV Loss 21882294
nsv465993 CNV Loss 19166990
nsv891711 CNV Gain 21882294
dgv905n27 CNV Loss 19166990
esv998186 CNV Deletion 20482838
esv2611442 CNV Deletion 19546169
dgv7933n71 CNV Loss 21882294
nsv891716 CNV Gain 21882294
esv2738015 CNV Deletion 23290073
esv2738016 CNV Deletion 23290073
dgv259n6 CNV Loss 16902084
esv1005132 CNV Deletion 20482838
nsv891720 CNV Loss 21882294
dgv7934n71 CNV Loss 21882294
nsv516210 CNV Loss 19592680
esv29963 CNV Loss 17803354

Variation tolerance for ZC3H3 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.06; 99.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H3 Gene

HapMap Linkage Disequilibrium report
ZC3H3
Human Gene Mutation Database (HGMD)
ZC3H3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H3 Gene

Disorders for ZC3H3 Gene

Relevant External Links for ZC3H3

Genetic Association Database (GAD)
ZC3H3
Human Genome Epidemiology (HuGE) Navigator
ZC3H3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H3

No disorders were found for ZC3H3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H3 Gene

Publications for ZC3H3 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PMID: 23509962) Greliche N. … TrAcgouAt D.A. (BMC Med. Genet. 2013) 3
  4. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ZC3H3 Gene

Sources for ZC3H3 Gene

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