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Aliases for ZC3H3 Gene

Aliases for ZC3H3 Gene

  • Zinc Finger CCCH-Type Containing 3 2 3
  • Zinc Finger CCCH-Type Domain Containing 3 2 3
  • ZC3HDC3 3 4
  • Zinc Finger CCCH Domain-Containing Protein 3 3
  • Zinc Finger CCCH Type Domain Containing 3 3
  • KIAA0150 4

External Ids for ZC3H3 Gene

Previous HGNC Symbols for ZC3H3 Gene

  • ZC3HDC3

Previous GeneCards Identifiers for ZC3H3 Gene

  • GC08M144591
  • GC08M144519
  • GC08M139772

Summaries for ZC3H3 Gene

GeneCards Summary for ZC3H3 Gene

ZC3H3 (Zinc Finger CCCH-Type Containing 3) is a Protein Coding gene. An important paralog of this gene is CPSF4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H3 Gene

Genomics for ZC3H3 Gene

Regulatory Elements for ZC3H3 Gene

Genomic Location for ZC3H3 Gene

Start:
143,437,655 bp from pter
End:
143,553,494 bp from pter
Size:
115,840 bases
Orientation:
Minus strand

Genomic View for ZC3H3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZC3H3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H3 Gene

Proteins for ZC3H3 Gene

  • Protein details for ZC3H3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXZ2-ZC3H3_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 3
    Protein Accession:
    Q8IXZ2
    Secondary Accessions:
    • Q14163
    • Q8N4E2
    • Q9BUS4

    Protein attributes for ZC3H3 Gene

    Size:
    948 amino acids
    Molecular mass:
    101941 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZC3H3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H3 Gene

Proteomics data for ZC3H3 Gene at MOPED

Post-translational modifications for ZC3H3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC3H3 Gene

Domains for ZC3H3 Gene

Gene Families for ZC3H3 Gene

HGNC:
  • ZC3H :Zinc fingers, CCCH-type domain containing

Protein Domains for ZC3H3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC3H3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXZ2

UniProtKB/Swiss-Prot:

ZC3H3_HUMAN :
  • Q8IXZ2
Similarity:
  • Contains 5 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZC3H3: view

Function for ZC3H3 Gene

Gene Ontology (GO) - Molecular Function for ZC3H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H3: view

miRNA for ZC3H3 Gene

miRTarBase miRNAs that target ZC3H3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZC3H3 Gene

Localization for ZC3H3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H3 Gene COMPARTMENTS Subcellular localization image for ZC3H3 gene
Compartment Confidence
nucleus 5
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZC3H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16115198
genes like me logo Genes that share ontologies with ZC3H3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZC3H3 Gene

Pathways for ZC3H3 Gene

SuperPathways for ZC3H3 Gene

No Data Available

Interacting Proteins for ZC3H3 Gene

Gene Ontology (GO) - Biological Process for ZC3H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IMP 19364924
GO:0010793 regulation of mRNA export from nucleus IMP 19364924
GO:0016973 poly(A)+ mRNA export from nucleus IMP 19364924
genes like me logo Genes that share ontologies with ZC3H3: view

No data available for Pathways by source for ZC3H3 Gene

Transcripts for ZC3H3 Gene

mRNA/cDNA for ZC3H3 Gene

Unigene Clusters for ZC3H3 Gene

Zinc finger CCCH-type containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H3 Gene

No ASD Table

Relevant External Links for ZC3H3 Gene

GeneLoc Exon Structure for
ZC3H3
ECgene alternative splicing isoforms for
ZC3H3

Expression for ZC3H3 Gene

mRNA expression in normal human tissues for ZC3H3 Gene

mRNA differential expression in normal tissues according to GTEx for ZC3H3 Gene

This gene is overexpressed in Whole Blood (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZC3H3 Gene

SOURCE GeneReport for Unigene cluster for ZC3H3 Gene Hs.521915

genes like me logo Genes that share expressions with ZC3H3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZC3H3 Gene

Orthologs for ZC3H3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZC3H3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H3 35
  • 98.66 (n)
  • 97.78 (a)
ZC3H3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZC3H3 35
  • 79.8 (n)
  • 72.44 (a)
ZC3H3 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H3 35
  • 80.81 (n)
  • 76 (a)
ZC3H3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm7353 36
  • 70 (a)
OneToMany
Zc3h3 35
  • 77.02 (n)
  • 71.37 (a)
Zc3h3 16
Zc3h3 36
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZC3H3 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H3 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3h3 35
  • 76.55 (n)
  • 70.87 (a)
chicken
(Gallus gallus)
Aves ZC3H3 35
  • 58.06 (n)
  • 52.04 (a)
ZC3H3 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1164 35
zc3h3 35
  • 55.82 (n)
  • 50.85 (a)
zebrafish
(Danio rerio)
Actinopterygii zc3h3 35
  • 46.73 (n)
  • 41.11 (a)
zc3h3 36
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ZC3H3 36
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTH1 36
  • 25 (a)
OneToMany
Species with no ortholog for ZC3H3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H3 Gene

ENSEMBL:
Gene Tree for ZC3H3 (if available)
TreeFam:
Gene Tree for ZC3H3 (if available)

Paralogs for ZC3H3 Gene

Paralogs for ZC3H3 Gene

genes like me logo Genes that share paralogs with ZC3H3: view

Variants for ZC3H3 Gene

Sequence variations from dbSNP and Humsavar for ZC3H3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs364417 -- 143,473,321(-) AGGGC(C/T)CAGAA intron-variant
rs364470 -- 143,495,324(-) TGTCA(A/G)TGGAG intron-variant
rs366767 -- 143,497,072(+) GCGAT(A/G)AAATA intron-variant
rs368315 -- 143,480,277(+) TGCCC(A/C)CGCAC intron-variant
rs369051 -- 143,466,636(+) CCCTC(A/G)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H3 Gene

Variant ID Type Subtype PubMed ID
dgv7920n71 CNV Loss 21882294
nsv891671 CNV Loss 21882294
nsv470247 CNV Loss 18288195
nsv891674 CNV Loss 21882294
nsv891676 CNV Loss 21882294
dgv7924n71 CNV Loss 21882294
dgv7925n71 CNV Loss 21882294
nsv891682 CNV Loss 21882294
dgv7926n71 CNV Loss 21882294
nsv891687 CNV Loss 21882294
dgv7927n71 CNV Loss 21882294
dgv7928n71 CNV Loss 21882294
dgv7929n71 CNV Loss 21882294
nsv891696 CNV Loss 21882294
nsv831487 CNV Gain 17160897
dgv7930n71 CNV Loss 21882294
nsv824766 CNV Gain 20364138
esv2673374 CNV Deletion 23128226
esv2738014 CNV Deletion 23290073
esv1091073 CNV Deletion 17803354
dgv7931n71 CNV Loss 21882294
dgv7932n71 CNV Loss 21882294
nsv465993 CNV Loss 19166990
nsv891711 CNV Gain 21882294
dgv905n27 CNV Loss 19166990
esv998186 CNV Deletion 20482838
esv2611442 CNV Deletion 19546169
dgv7933n71 CNV Loss 21882294
nsv891716 CNV Gain 21882294
esv2738015 CNV Deletion 23290073
esv2738016 CNV Deletion 23290073
dgv259n6 CNV Loss 16902084
esv1005132 CNV Deletion 20482838
nsv891720 CNV Loss 21882294
dgv7934n71 CNV Loss 21882294
nsv516210 CNV Loss 19592680
esv29963 CNV Loss 17803354

Relevant External Links for ZC3H3 Gene

HapMap Linkage Disequilibrium report
ZC3H3
Human Gene Mutation Database (HGMD)
ZC3H3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H3 Gene

Disorders for ZC3H3 Gene

Relevant External Links for ZC3H3

Genetic Association Database (GAD)
ZC3H3
Human Genome Epidemiology (HuGE) Navigator
ZC3H3
genes like me logo Genes that share disorders with ZC3H3: view

No data available for UniProtKB/Swiss-Prot for ZC3H3 Gene

Publications for ZC3H3 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ZC3H3 Gene

Sources for ZC3H3 Gene

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