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ZC3H3 Gene

protein-coding GIFtS: 50

GC08M144591

zinc finger CCCH-type containing 3
(Previous name: zinc finger CCCH-type domain containing 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZC3HDC3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
KIAA0150 ^¹, ², ³
ZC3HDC3 ^², ³

Descriptions
zinc finger CCCH type domain containing 3 ^²
zinc finger CCCH-type containing 3 ^²
zinc finger CCCH-type domain containing 3 ^¹, ²

External Ids
HGNC: 28972¹
Entrez Gene: 23144²
UniProtKB: Q8IXZ2³
Ensembl: ENSG00000014164⁷

Search outside databases for aliases for ZC3H3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZC3H3 gene

Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3

ZC3H3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M144591: (about GC identifiers)

Start:	144,590,968 bp from pter
End:	144,694,763 bp from pter
Size:	103,796 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_023684.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZC3H3_HUMAN, Q8IXZ2 (See protein sequence)

Recommended Name: Zinc finger CCCH domain-containing protein 3

Size: 948 amino acids; 101930 Da

Secondary accessions: Q14163 Q8N4E2 Q9BUS4

Alternative splicing: 2 isoforms: Q8IXZ2-1 Q8IXZ2-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055932.2

ENSEMBL proteins:

ENSP00000262577

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ZC3H3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZC3H3
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZC3H3

Assays for ZC3H3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8IXZ2

ProtoNet protein and cluster: Q8IXZ2

1 Blocks protein family: IPB000571 Zn-finger

UniProtKB/Swiss-Prot: ZC3H3_HUMAN, Q8IXZ2

Similarity: Contains 5 C3H1-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZC3H3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015117

Applied Biosystems Silencer® siRNAs for ZC3H3

Sigma-Aldrich siRNA for ZC3H3

Sigma-Aldrich shRNA for ZC3H3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZC3H3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015117
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015117
untagged cDNA clones in CMV expression vector (see all 2): BC034435

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015117

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for ZC3H3 (ENSP00000262577³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TIGD5	ENSP00000315906³	STRING (score=.706)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZC3H3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZC3H3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015117

Sigma-Aldrich siRNA for ZC3H3

Sigma-Aldrich shRNA for ZC3H3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015117

REFSEQ mRNAs for ZC3H3 gene:

NM_015117.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015117

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015117
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015117
                                 untagged cDNA clones in CMV expression vector (see all 2): BC034435

Additional cDNA sequence:

BC034435.1 BC038670.1 D63484.1

7 DOTS entries:

DT.442780 DT.75100207 DT.95273917 DT.100009916 DT.100803446 DT.120636026 DT.97839896

24/98 AceView cDNA sequences (see all 98 ):

BX279623 AW135082 AL079951 D63484 BQ672330 BQ671910 BI554154 BM148116

CK903970 BX341764 BE386102 AI917334 BM053056 BG760659 BF966027 BX350451

BQ017101 BF825869 BF590957 NM_015117 BE275975 BG703936 AW024128 BU931425

highest scoring ESTs for ZC3H3:

D63484 AL530152 BC038670 BG703936 BG748981 BI547900 BI908000 BI910525 BM148116 BM149148

Unigene Cluster for ZC3H3:

Zinc finger CCCH-type containing 3

Hs.521915 [show with all ESTs]

Unigene Representative Sequence: NM_015117

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000262577

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ZC3H3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H3

¹ / ² / ³

3 probe-sets matching ZC3H3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41078_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	D63484	1.00	1.00	1.00	1
213445_at²^{, 3}	U133-A	2	1.00	0.95	--	--	D63484	1.00	1.00	1.00	1
213445_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACCAGCGTGT

SOURCE GeneReport for Unigene cluster: Hs.521915
Expression variation in blood from EXPOLDB for ZC3H3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ZC3H3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZC3H3¹	--	zinc finger CCCH-type containing 3	80.78(n) 76.57(a)	482077 XM_539198.2 XP_539198.2
chimpanzee (Pan troglodytes)	ZC3H3¹	--	zinc finger CCCH-type containing 3	98.91(n) 98.1(a)	464443 XM_519998.2 XP_519998.2
cow (Bos taurus)	ZC3H3¹	--	zinc finger CCCH-type containing 3	81.06(n) 75.03(a)	515615 XM_593664.2 XP_593664.2
rat (Rattus norvegicus)	Zc3h3¹	--	zinc finger CCCH type containing 3	76.73(n) 71.4(a)	300032 XM_235433.4 XP_235433.4
mouse (Mus musculus)	Zc3h3⁵ EG664817¹	15⁵	zinc finger CCCH type containing 3⁵ predicted gene, EG664817¹	77.17(n)¹ 71.37(a)¹	664817¹ XM_972852.2¹ XP_977946.1¹ AJ516034⁵ AK086799⁵ (see all 12)

About this table Species with no ortholog for ZC3H3

ENSEMBL Gene Tree for ZC3H3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZC3H3 gene

CPSF4L² CPSF4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/812 NCBI SNPs in ZC3H3 are shown (see all 812 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 307)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3750207^1,2	A,C,F,H	144692227(-)	`GAGGAA/CACCCC`	1	E/D	mis¹		4	EU EA WA	414
	rs11779379^1,2	A,C,F,H	144695786(+)	`ggaaaC/Tcagag`	1	--	ng3¹		4	EU EA WA	418
	rs1318196^1,2	A,C,F,H	144691485(-)	`AGGCCA/GGCAGC`	1	S/G	mis¹ ese³		9	MN EA EU WA NA	2302
	rs6998917^1,2	A,C,F,H	144695271(+)	`GATAGA/GCATGT`	1	--	ng3¹		4	EU EA WA	414
	rs2242092^1,2	A,C,F,H	144694878(-)	`GTCAGG/CGCGAC`	1	--	ng3¹		7	EU EA WA NA	508
	rs3750206^1,2	A,C,F,H	144692234(-)	`AGAATT/ATGAGG`	1	Y/F	mis¹ ese³		3	EA WA	298
	rs2294117^1,2	A,C,F,H	144591290(-)	`TACCCC/TACAGG`	1	--	ut3¹ ese³		8	EA NA EU WA	2038
	rs4874147^1,2	A,C,F,H	144691326(+)	`GCTGCC/TGCGTC`	1	S/G	mis¹		13	MN EA NA EU WA	1228
	rs2242093^1,2	C,F,H	144694717(-)	`GAGATA/GTTACG`	1	I/M	mis¹		4	EU EA WA	418
	rs6991958^1,2	C,F,H	144695581(+)	`ataccC/Taatag`	1	--	ng3¹		4	EU EA WA	412

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HapMap Linkage Disequilibrium images for ZC3H3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Gene Mutation Database: ZC3H3

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for ZC3H3 gene:

Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)^{2, 3, 4} Nagase T....Nomura N. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)⁴ Imami K.... Ishihama Y. (2008)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS Spectra. (PubMed id 17924679)⁴ Yu L.-R.... Veenstra T.D. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23144	HGNC: 28972	AceView: ZC3HDC3	Ensembl:ENSG00000014164	euGenes: HUgn23144
ECgene: ZC3H3	H-InvDB: ZC3H3

(According to HUGE)
About This Section

HUGE: KIAA0150

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZC3H3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ZC3H3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZC3H3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZC3H3		Antibodies for ZC3H3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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ZC3H3 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for ZC3H3

Summaries
for ZC3H3

Genomic Location
for ZC3H3

Proteins
for ZC3H3

Protein Domains/
Families
for ZC3H3

Gene Function
for ZC3H3

Pathways & Interactions
for ZC3H3

Drugs & Compounds
for ZC3H3

Transcripts
for ZC3H3

Expression
for ZC3H3

Orthologs
for ZC3H3

Paralogs
for ZC3H3

SNPs/Variants
for ZC3H3

Disorders & Mutations
for ZC3H3

Medical News
for ZC3H3

Publications
for ZC3H3

Search for ZC3H3

Genome Databases showing ZC3H3

Other Databases showing ZC3H3

Specialized Databases showing ZC3H3

Licensable Technologies
for ZC3H3

Services
for ZC3H3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZC3H3 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor ZC3H3

Summariesfor ZC3H3

Genomic Locationfor ZC3H3

Proteinsfor ZC3H3

Protein Domains/Familiesfor ZC3H3

Gene Functionfor ZC3H3

Pathways & Interactionsfor ZC3H3

Drugs & Compoundsfor ZC3H3

Transcriptsfor ZC3H3

Expression for ZC3H3

Orthologsfor ZC3H3

Paralogsfor ZC3H3

SNPs/Variantsfor ZC3H3

Disorders & Mutationsfor ZC3H3

Medical Newsfor ZC3H3

Publicationsfor ZC3H3

Search for ZC3H3

Genome Databases showing ZC3H3

Other Databases showing ZC3H3

Specialized Databases showing ZC3H3

Licensable Technologiesfor ZC3H3

Servicesfor ZC3H3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZC3H3

Summaries
for ZC3H3

Genomic Location
for ZC3H3

Proteins
for ZC3H3

Protein Domains/
Families
for ZC3H3

Gene Function
for ZC3H3

Pathways & Interactions
for ZC3H3

Drugs & Compounds
for ZC3H3

Transcripts
for ZC3H3

Expression
for ZC3H3

Orthologs
for ZC3H3

Paralogs
for ZC3H3

SNPs/Variants
for ZC3H3

Disorders & Mutations
for ZC3H3

Medical News
for ZC3H3

Publications
for ZC3H3

Licensable Technologies
for ZC3H3

Services
for ZC3H3