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Aliases for ZC3H18 Gene

Aliases for ZC3H18 Gene

  • Zinc Finger CCCH-Type Containing 18 2 3 5
  • Nuclear Protein NHN1 3 4
  • NHN1 3 4
  • Zinc Finger CCCH Domain-Containing Protein 18 3
  • Conserved Nuclear Protein NHN1 3

External Ids for ZC3H18 Gene

Previous GeneCards Identifiers for ZC3H18 Gene

  • GC16P087167
  • GC16P074331

Summaries for ZC3H18 Gene

GeneCards Summary for ZC3H18 Gene

ZC3H18 (Zinc Finger CCCH-Type Containing 18) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H18 Gene

Genomics for ZC3H18 Gene

Regulatory Elements for ZC3H18 Gene

Enhancers for ZC3H18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F088615 1.4 FANTOM5 ENCODE 14.7 +48.1 48114 5.5 HDGF PKNOX1 MLX CREB3L1 SIN3A ARID4B FEZF1 DMAP1 YY1 FOS CYBA IL17C ZC3H18 SNAI3 MVD RNF166 ZFPM1
GH16F088598 1 Ensembl ENCODE 17.5 +29.0 29001 2.1 ZNF511 MAX CEBPB CEBPG RAD21 YY1 NR2F2 IRF9 ZNF121 CEBPA ZC3H18 CYBA IL17C
GH16F088442 1.4 Ensembl ENCODE 12 -127.2 -127237 2.0 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 CTU2 ZC3H18 ZNF469 ENSG00000259877 ENSG00000260121 ZFPM1 GC16P088248
GH16F088524 1.3 Ensembl ENCODE 11.9 -43.9 -43936 4.0 HDGF PKNOX1 ARID4B ZNF48 ZNF121 GLIS2 GATA2 ZNF143 KLF13 ZNF263 LOC100128882 ZFPM1 ZC3H18 ZNF469 SNAI3-AS1 GALNS MIR5189
GH16F088596 1.1 ENCODE 12.5 +26.4 26359 0.1 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF778 ZC3H18 IL17C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC3H18 on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000512073 -78 2200 HDGF CREB3L1 ARNT MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143

Genomic Location for ZC3H18 Gene

Chromosome:
16
Start:
88,570,379 bp from pter
End:
88,631,966 bp from pter
Size:
61,588 bases
Orientation:
Plus strand

Genomic View for ZC3H18 Gene

Genes around ZC3H18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H18 Gene

Proteins for ZC3H18 Gene

  • Protein details for ZC3H18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VM9-ZCH18_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 18
    Protein Accession:
    Q86VM9
    Secondary Accessions:
    • Q96DG4
    • Q96MP7

    Protein attributes for ZC3H18 Gene

    Size:
    953 amino acids
    Molecular mass:
    106378 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZC3H18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H18 Gene

Post-translational modifications for ZC3H18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZC3H18 Gene

Domains & Families for ZC3H18 Gene

Gene Families for ZC3H18 Gene

Protein Domains for ZC3H18 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VM9

UniProtKB/Swiss-Prot:

ZCH18_HUMAN :
  • Contains 1 C3H1-type zinc finger.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with ZC3H18: view

Function for ZC3H18 Gene

Gene Ontology (GO) - Molecular Function for ZC3H18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H18: view
genes like me logo Genes that share phenotypes with ZC3H18: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H18 Gene

Localization for ZC3H18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H18 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZC3H18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZC3H18: view

Pathways & Interactions for ZC3H18 Gene

SuperPathways for ZC3H18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZC3H18 Gene

Transcripts for ZC3H18 Gene

Unigene Clusters for ZC3H18 Gene

Zinc finger CCCH-type containing 18:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H18 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6: - -
SP7: - - - -
SP8: - - - - - - - - - - - - - -
SP9:
SP10:

ExUns: 18 ^ 19a · 19b ^ 20a · 20b
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ZC3H18 Gene

GeneLoc Exon Structure for
ZC3H18
ECgene alternative splicing isoforms for
ZC3H18

Expression for ZC3H18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZC3H18 Gene

Protein differential expression in normal tissues from HIPED for ZC3H18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.4) and Lavage (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZC3H18 Gene



Protein tissue co-expression partners for ZC3H18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC3H18 Gene:

ZC3H18

SOURCE GeneReport for Unigene cluster for ZC3H18 Gene:

Hs.93670
genes like me logo Genes that share expression patterns with ZC3H18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H18 Gene

Orthologs for ZC3H18 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H18 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZC3H18 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3h18 34
  • 85.67 (n)
mouse
(Mus musculus)
Mammalia Zc3h18 34 16 35
  • 85.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H18 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H18 34 35
  • 84.98 (n)
cow
(Bos Taurus)
Mammalia ZC3H18 34 35
  • 81.29 (n)
chicken
(Gallus gallus)
Aves ZC3H18 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC3H18 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20181 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14309 34
zebrafish
(Danio rerio)
Actinopterygii zc3h18 35
  • 49 (a)
OneToOne
Dr.24473 34
fruit fly
(Drosophila melanogaster)
Insecta CG1677 35
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for ZC3H18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H18 Gene

ENSEMBL:
Gene Tree for ZC3H18 (if available)
TreeFam:
Gene Tree for ZC3H18 (if available)

Paralogs for ZC3H18 Gene

(2) SIMAP similar genes for ZC3H18 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZC3H18: view

No data available for Paralogs for ZC3H18 Gene

Variants for ZC3H18 Gene

Sequence variations from dbSNP and Humsavar for ZC3H18 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1057468 -- 88,609,012(+) TTCAG(A/G)GTGCA intron-variant, reference, synonymous-codon, missense
rs10711164 -- 88,615,209(+) CTGCC(-/T)TTTGA intron-variant
rs10852630 -- 88,591,463(+) GCTAT(G/T)TGGGA intron-variant
rs1105943 -- 88,577,108(+) TTTGC(A/C)GAACC splice-acceptor-variant
rs11076676 -- 88,568,534(+) CGATC(C/T)GCCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZC3H18 Gene

Variant ID Type Subtype PubMed ID
nsv833325 CNV loss 17160897
nsv952070 CNV deletion 24416366
nsv573672 CNV loss 21841781
nsv573668 CNV loss 21841781
nsv573658 CNV loss 21841781
nsv523859 CNV gain 19592680
nsv1926 CNV insertion 18451855
nsv1113831 CNV deletion 24896259
esv3639553 CNV gain 21293372
esv3639552 CNV loss 21293372
esv3553873 CNV deletion 23714750
esv28119 CNV loss 19812545
esv2678436 CNV deletion 23128226
dgv5309n54 CNV loss 21841781
dgv5308n54 CNV loss 21841781

Variation tolerance for ZC3H18 Gene

Residual Variation Intolerance Score: 7.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H18 Gene

Disorders for ZC3H18 Gene

Relevant External Links for ZC3H18

Genetic Association Database (GAD)
ZC3H18
Human Genome Epidemiology (HuGE) Navigator
ZC3H18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H18

No disorders were found for ZC3H18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H18 Gene

Publications for ZC3H18 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF. (PMID: 17579712) Hastings M.L. … Krainer A.R. (PLoS ONE 2007) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for ZC3H18 Gene

Sources for ZC3H18 Gene

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