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Aliases for ZC3H18 Gene

Aliases for ZC3H18 Gene

  • Zinc Finger CCCH-Type Containing 18 2 3 5
  • Nuclear Protein NHN1 3 4
  • NHN1 3 4
  • Zinc Finger CCCH Domain-Containing Protein 18 3
  • Conserved Nuclear Protein NHN1 3

External Ids for ZC3H18 Gene

Previous GeneCards Identifiers for ZC3H18 Gene

  • GC16P087167
  • GC16P074331

Summaries for ZC3H18 Gene

GeneCards Summary for ZC3H18 Gene

ZC3H18 (Zinc Finger CCCH-Type Containing 18) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H18 Gene

Genomics for ZC3H18 Gene

Regulatory Elements for ZC3H18 Gene

Enhancers for ZC3H18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZC3H18 on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZC3H18 Gene

88,570,379 bp from pter
88,631,966 bp from pter
61,588 bases
Plus strand

Genomic View for ZC3H18 Gene

Genes around ZC3H18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H18 Gene

Proteins for ZC3H18 Gene

  • Protein details for ZC3H18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCCH domain-containing protein 18
    Protein Accession:
    Secondary Accessions:
    • Q96DG4
    • Q96MP7

    Protein attributes for ZC3H18 Gene

    953 amino acids
    Molecular mass:
    106378 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZC3H18 Gene


neXtProt entry for ZC3H18 Gene

Post-translational modifications for ZC3H18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H18 Gene

No data available for DME Specific Peptides for ZC3H18 Gene

Domains & Families for ZC3H18 Gene

Gene Families for ZC3H18 Gene

Protein Domains for ZC3H18 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C3H1-type zinc finger.
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with ZC3H18: view

Function for ZC3H18 Gene

Gene Ontology (GO) - Molecular Function for ZC3H18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H18: view
genes like me logo Genes that share phenotypes with ZC3H18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H18 Gene

Localization for ZC3H18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H18 Gene

Subcellular locations from

Jensen Localization Image for ZC3H18 Gene COMPARTMENTS Subcellular localization image for ZC3H18 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZC3H18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZC3H18: view

Pathways & Interactions for ZC3H18 Gene

SuperPathways for ZC3H18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H18 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZC3H18 Gene

Drugs & Compounds for ZC3H18 Gene

No Compound Related Data Available

Transcripts for ZC3H18 Gene

Unigene Clusters for ZC3H18 Gene

Zinc finger CCCH-type containing 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H18 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^
SP1: -
SP2: -
SP3: - -
SP6: - -
SP7: - - - -
SP8: - - - - - - - - - - - - - -

ExUns: 18 ^ 19a · 19b ^ 20a · 20b
SP1: -
SP5: -

Relevant External Links for ZC3H18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H18 Gene

mRNA expression in normal human tissues for ZC3H18 Gene

Protein differential expression in normal tissues from HIPED for ZC3H18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.4) and Lavage (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZC3H18 Gene

Protein tissue co-expression partners for ZC3H18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC3H18 Gene:


SOURCE GeneReport for Unigene cluster for ZC3H18 Gene:

genes like me logo Genes that share expression patterns with ZC3H18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H18 Gene

Orthologs for ZC3H18 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZC3H18 34
  • 81.29 (n)
  • 83.58 (a)
ZC3H18 35
  • 87 (a)
(Canis familiaris)
Mammalia ZC3H18 34
  • 84.98 (n)
  • 88.95 (a)
ZC3H18 35
  • 88 (a)
(Mus musculus)
Mammalia Zc3h18 34
  • 85.48 (n)
  • 90.93 (a)
Zc3h18 16
Zc3h18 35
  • 89 (a)
(Rattus norvegicus)
Mammalia Zc3h18 34
  • 85.67 (n)
  • 90.92 (a)
(Monodelphis domestica)
Mammalia ZC3H18 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia ZC3H18 35
  • 85 (a)
(Pan troglodytes)
Mammalia ZC3H18 35
  • 97 (a)
(Gallus gallus)
Aves ZC3H18 35
  • 75 (a)
(Anolis carolinensis)
Reptilia ZC3H18 35
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20181 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14309 34
(Danio rerio)
Actinopterygii Dr.24473 34
zc3h18 35
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1677 35
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
Species where no ortholog for ZC3H18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H18 Gene

Gene Tree for ZC3H18 (if available)
Gene Tree for ZC3H18 (if available)

Paralogs for ZC3H18 Gene

(2) SIMAP similar genes for ZC3H18 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZC3H18: view

No data available for Paralogs for ZC3H18 Gene

Variants for ZC3H18 Gene

Sequence variations from dbSNP and Humsavar for ZC3H18 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs34808360 - 88,608,947(-) GTCTG(C/T)GTAAG intron-variant, reference, missense, utr-variant-5-prime
rs17855686 - 88,611,380(+) GGAGC(A/G)CGAGC intron-variant, reference, missense
rs3751675 -- 88,622,424(-) CAAGG(C/T)GCTGA intron-variant
rs3751678 -- 88,600,145(-) CTAAC(C/G)CTTCC intron-variant
rs3751679 -- 88,588,343(-) CTGGC(C/T)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H18 Gene

Variant ID Type Subtype PubMed ID
dgv5308n54 CNV loss 21841781
dgv5309n54 CNV loss 21841781
esv2678436 CNV deletion 23128226
esv28119 CNV loss 19812545
esv3553873 CNV deletion 23714750
esv3639552 CNV loss 21293372
esv3639553 CNV gain 21293372
nsv1113831 CNV deletion 24896259
nsv1926 CNV insertion 18451855
nsv523859 CNV gain 19592680
nsv573658 CNV loss 21841781
nsv573668 CNV loss 21841781
nsv573672 CNV loss 21841781
nsv833325 CNV loss 17160897
nsv952070 CNV deletion 24416366

Variation tolerance for ZC3H18 Gene

Residual Variation Intolerance Score: 7.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H18 Gene

Disorders for ZC3H18 Gene

Relevant External Links for ZC3H18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZC3H18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H18 Gene

Publications for ZC3H18 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF. (PMID: 17579712) Hastings M.L. … Krainer A.R. (PLoS ONE 2007) 2 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 65
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 65

Products for ZC3H18 Gene

Sources for ZC3H18 Gene

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