Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZC3H18 Gene

protein-coding   GIFtS: 50
GCID: GC16P088636

Zinc Finger CCCH-Type Containing 18

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Finger CCCH-Type Containing 181 2
Nuclear Protein NHN12 3
NHN12 3
Conserved Nuclear Protein NHN12
Zinc Finger CCCH Domain-Containing Protein 182

External Ids:    HGNC: 250911   Entrez Gene: 1242452   Ensembl: ENSG000001585457   UniProtKB: Q86VM93   

Export aliases for ZC3H18 gene to outside databases

Previous GC identifers: GC16P087167 GC16P074331


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ZC3H18 Gene:
ZC3H18 (zinc finger CCCH-type containing 18) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZC3H18 gene promoter:
         HOXA9B   HOXA9   Elk-1   RFX1   RelA   CUTL1   AP-4   MIF-1   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC3H18 promoter sequence
   Search Chromatin IP Primers for ZC3H18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZC3H18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.2   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24.2-q24.3

ZC3H18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3H18 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P088636:  view genomic region     (about GC identifiers)

Start:
88,636,789 bp from pter      End:
88,698,374 bp from pter
Size:
61,586 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZCH18_HUMAN, Q86VM9 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 18  
Size: 953 amino acids; 106378 Da
Secondary accessions: Q96DG4 Q96MP7
Alternative splicing: 2 isoforms:  Q86VM9-1   Q86VM9-2   

Explore the universe of human proteins at neXtProt for ZC3H18: NX_Q86VM9

Explore proteomics data for ZC3H18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZC3H18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653205.3  
    ENSEMBL proteins: 
     ENSP00000301011   ENSP00000416951   ENSP00000455260   ENSP00000455083   ENSP00000456334  
     ENSP00000456241  

    ZC3H18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZC3H18
    GenScript Custom Purified and Recombinant Proteins Services for ZC3H18
    Novus Biologicals ZC3H18 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZC3H18

     
    Search eBioscience for Proteins for ZC3H18 

    ZC3H18 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZC3H18
    Novus Biologicals ZC3H18 Antibodies
    Abcam antibodies for ZC3H18
    Cloud-Clone Corp. Antibodies for ZC3H18
    Search ThermoFisher Antibodies for ZC3H18
    Search LSBio for Antibodies for ZC3H18

    ZC3H18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZC3H18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZC3H18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZC3H18
    Cloud-Clone Corp. CLIAs for ZC3H18
    Search eBioscience for ELISAs for ZC3H18 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZC3H: Zinc fingers, CCCH-type domain containing

    1 InterPro protein domain:
     IPR000571 Znf_CCCH

    Graphical View of Domain Structure for InterPro Entry Q86VM9

    ProtoNet protein and cluster: Q86VM9

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: ZCH18_HUMAN, Q86VM9
    Similarity: Contains 1 C3H1-type zinc finger


    Find genes that share domains with ZC3H18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZC3H18           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for ZC3H18:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased Wnt reporter activit 
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZC3H18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZC3H18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZC3H18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZC3H18

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZC3H18:
    hsa-mir-31-5p (MIRT049858), hsa-mir-10a-5p (MIRT047551), hsa-mir-106b-5p (MIRT044256), hsa-let-7a-5p (MIRT052361), hsa-mir-484 (MIRT041631), hsa-mir-17-5p (MIRT050795), hsa-mir-93-3p (MIRT038721), hsa-mir-92a-3p (MIRT049259), hsa-mir-29b-2-5p (MIRT038709), hsa-mir-18b-5p (MIRT042403), hsa-mir-10b-5p (MIRT047405), hsa-let-7f-5p (MIRT051354), hsa-mir-218-5p (MIRT046984), hsa-mir-1914-3p (MIRT035777), hsa-mir-183-5p (MIRT047038), hsa-mir-18a-5p (MIRT050651)

    Block miRNA regulation of human, mouse, rat ZC3H18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZC3H18 (see all 18):
    hsa-miR-644 hsa-miR-4251 hsa-miR-539 hsa-miR-4267 hsa-miR-373* hsa-miR-3667-5p hsa-miR-641 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidZC3H18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZC3H18
    Predesigned siRNA for gene silencing in human, mouse, rat ZC3H18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZC3H18

    Clone
    Products:
         
    OriGene clones in human, mouse for ZC3H18 (see all 7)
    OriGene ORF clones in mouse, rat for ZC3H18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZC3H18 (NM_144604)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZC3H18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H18

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZC3H18
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZC3H18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZCH18_HUMAN, Q86VM9: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with ZC3H18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZC3H18
    Interactions:

        Search GeneGlobe Interaction Network for ZC3H18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for ZC3H18 (Q86VM93 ENSP000003010114) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    RNPS1Q152873, ENSP000003158594I2D: score=1 STRING: ENSP00000315859
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZC3H18 (ZCH18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZC3H18 gene: 
    NM_144604.3  

    Unigene Cluster for ZC3H18:

    Zinc finger CCCH-type containing 18
    Hs.93670  [show with all ESTs]
    Unigene Representative Sequence: NM_144604
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301011(uc010voy.1 uc002fky.3 uc010voz.2 uc010chw.3)
    ENST00000452588(uc010vpa.1 uc021tmm.1) ENST00000569435 ENST00000567085
    ENST00000568072 ENST00000564161 ENST00000564341 ENST00000563382 ENST00000566496(uc002fkz.3)
    ENST00000565583 ENST00000566317 ENST00000566660
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZC3H18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZC3H18 (see all 18):
    hsa-miR-644 hsa-miR-4251 hsa-miR-539 hsa-miR-4267 hsa-miR-373* hsa-miR-3667-5p hsa-miR-641 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidZC3H18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZC3H18
    Predesigned siRNA for gene silencing in human, mouse, rat ZC3H18
    Clone
    Products:
         
    OriGene clones in human, mouse for ZC3H18 (see all 7)
    OriGene ORF clones in mouse, rat for ZC3H18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZC3H18 (NM_144604)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZC3H18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H18
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZC3H18
    OriGene qSTAR qPCR primer pairs in human, mouse for ZC3H18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZC3H18
      QuantiTect SYBR Green Assays in human, mouse, rat ZC3H18
      QuantiFast Probe-based Assays in human, mouse, rat ZC3H18

    Additional mRNA sequence: 

    AK026317.1 AK091849.1 AK093394.1 AK225807.1 AK300254.1 AK302716.1 BC001584.1 BC050463.1 

    17 DOTS entries:

    DT.100825978  DT.446670  DT.100030749  DT.95231376  DT.97819709  DT.120657918  DT.407214  DT.91742448 
    DT.100825955  DT.100825979  DT.120657934  DT.75192172  DT.95276091  DT.95276093  DT.95276094  DT.97802318 
    DT.100714906 

    Selected AceView cDNA sequences (see all 148):

    BQ422541 BQ071579 BQ891735 CA436836 CR601060 BU153524 BQ425175 AI056419 
    BC050463 BM904294 BQ053607 AI859239 BQ448619 AA768109 BC001584 CB130888 
    BQ647703 CA432315 BQ083532 AA831175 AI281156 BQ224019 AX748097 BE503358 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H18 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^
    SP1:                                                                                                                                            -               
    SP2:                                                        -                                                                                                   
    SP3:                                                  -     -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19a · 19b ^ 20a · 20b
    SP1:        -                     
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:        -                     


    ECgene alternative splicing isoforms for ZC3H18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZC3H18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATTACAA
    ZC3H18 Expression
    About this image


    ZC3H18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Endochondral Facial Bones
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Hippocampus
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Meckel's Cartilage
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    ZC3H18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZC3H18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.93670
        Custom PCR Arrays for ZC3H18
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ZC3H18
    OriGene qSTAR qPCR primer pairs in human, mouse for ZC3H18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZC3H18
    QuantiTect SYBR Green Assays in human, mouse, rat ZC3H18
    QuantiFast Probe-based Assays in human, mouse, rat ZC3H18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZC3H18 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc3h181 , 5 zinc finger CCCH-type containing 181, 5 85.48(n)1
    90.93(a)1
      8 (70.98 cM)5
    760141  NM_001029993.11  NP_001025164.11 
     1223766095 
    chicken
    (Gallus gallus)
    Aves ZC3H186
    zinc finger CCCH-type containing 18
    75(a)
    1 ↔ 1
    11(17853540-17887022)
    lizard
    (Anolis carolinensis)
    Reptilia ZC3H186
    zinc finger CCCH-type containing 18
    71(a)
    1 ↔ 1
    GL343670.1(5494-68849)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143092 Xenopus laevis transcribed sequence with weak similarity more 77.16(n)    BJ065779.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.244732 Transcribed sequence with weak similarity to protein more 74.77(n)    CF996561.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16776
    --
    24(a)
    1 ↔ 1
    X(7175122-7299793)
    barley
    (Hordeum vulgare)
    Liliopsida BI958440.12   -- 73.78(n)    BI958440.1 


    ENSEMBL Gene Tree for ZC3H18 (if available)
    TreeFam Gene Tree for ZC3H18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZC3H18 gene
    2 SIMAP similar genes for ZC3H18 using alignment to 6 protein entries:     ZCH18_HUMAN (see all proteins):
    NHN1    FLJ00419

    Find genes that share paralogs with ZC3H18           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZC3H18 (see all 1774)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124458381,2
    C,F,H--88634861(+) ACGCCC/TGGCTA 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1467152771,2
    C--88634913(+) GCCAGC/GATGGT 1 -- us2k10--------
    rs110766761,2
    C,F,A,H--88634942(+) CGATCC/TGCCCG 1 -- us2k17Minor allele frequency- T:0.17NA CSA 12
    rs1502321461,2
    C--88634949(+) CCCGCC/TTCGAC 1 -- us2k10--------
    rs1157323961,2
    C,F--88635021(+) TATGAC/GTACTA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs80480421,2
    C,H--88635057(+) GTCTCG/ATGCCC 1 -- us2k114Minor allele frequency- A:0.02NA WA CSA EA 377
    rs1894930081,2
    C--88635064(+) GCCCAC/TGGGCA 1 -- us2k10--------
    rs1147474481,2
    F--88635205(+) GAAGGC/GACATT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs116468481,2
    C,F,A,H--88635310(+) TAACTA/GACATT 1 -- us2k110Minor allele frequency- G:0.16NA EA WA 726
    rs1806745111,2
    --88635328(+) AAAGAA/GGCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZC3H18 (88636789 - 88698374 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZC3H18 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678436CNV Deletion23128226
    nsv1926CNV Insertion18451855
    nsv907278CNV Loss21882294
    dgv2977n71CNV Loss21882294
    nsv907268CNV Loss21882294
    nsv907264CNV Loss21882294
    nsv907255CNV Loss21882294
    dgv2978n71CNV Loss21882294
    dgv2979n71CNV Loss21882294
    nsv907226CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZC3H18
    DNA2.0 Custom Variant and Variant Library Synthesis for ZC3H18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease from the University of Copenhagen DISEASES database for ZC3H18:
    Severe congenital neutropenia

    Find genes that share disorders with ZC3H18           About GenesLikeMe

    Genetic Association Database (GAD): ZC3H18
    Human Genome Epidemiology (HuGE) Navigator: ZC3H18 (1 document)

    Export disorders for ZC3H18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZC3H18 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with ZC3H18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF. (PubMed id 17579712)1, 3 Hastings M.L.... Krainer A.R. (PLoS ONE 2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Maintenance of silent chromatin through replication requires SWI/SNF- like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P.... Mermoud J.E. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 124245 HGNC: 25091 AceView: LOC124245 Ensembl:ENSG00000158545 euGenes: HUgn124245
    ECgene: ZC3H18 H-InvDB: ZC3H18

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZC3H18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZC3H18 gene:
    Search GeneIP for patents involving ZC3H18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZC3H18  
     OriGene qPCR primer pairs and template standards for ZC3H18   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZC3H18  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZC3H18   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZC3H18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZC3H18   OriGene Custom Protein Services for ZC3H18  

     
     
     Block miRNA regulation of human, mouse, rat ZC3H18 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZC3H18
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZC3H18 Predesigned siRNA for gene silencing in human, mouse, rat ZC3H18
     QuantiFast Probe-based Assays in human, mouse, rat ZC3H18 QuantiTect SYBR Green Assays in human, mouse, rat ZC3H18
     Custom PCR Arrays for ZC3H18 Search Chromatin IP Primers for ZC3H18
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZC3H18  Search GeneGlobe Interaction Network for ZC3H18
     Regulatory tfbs in ZC3H18 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZC3H18 GenScript cDNA clones with any tag delivered in your preferred vector for ZC3H18
     GenScript Custom Assay Services for ZC3H18 GenScript Custom overexpressing Cell Line Services for ZC3H18
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZC3H18 (ZCH18)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZC3H18 antibodies
     ZC3H18 lysates
     Antibodies for ZC3H18
     See all of Abcam's Antibodies, Kits and Proteins for ZC3H18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZC3H18
     Antibodies for ZC3H18
     ELISAs for ZC3H18
     CLIAs for ZC3H18



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZC3H18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H18
     SwitchGear 3'UTR luciferase reporter plasmids for ZC3H18
     SwitchGear Promoter luciferase reporter plasmids for ZC3H18
     Search ThermoFisher Antibodies for ZC3H18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H18
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZC3H18
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZC3H18
     Search LSBio for Antibodies for ZC3H18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ZC3H18
      Search eBioscience for proteins for ZC3H18
      Search eBioscience for elisas for ZC3H18
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZC3H18 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4