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Aliases for ZC3H15 Gene

Aliases for ZC3H15 Gene

  • Zinc Finger CCCH-Type Containing 15 2 3 5
  • Likely Ortholog Of Mouse Immediate Early Response Erythropoietin 4 3 4
  • DRG Family-Regulatory Protein 1 3 4
  • LEREPO4 3 4
  • Likely Ortholog Of Mouse Immediate Early Response 2
  • Erythropoietin 4 2
  • MSTP012 3
  • HT010 3
  • DFRP1 4

External Ids for ZC3H15 Gene

Previous GeneCards Identifiers for ZC3H15 Gene

  • GC02P187060
  • GC02P187350
  • GC02P179210

Summaries for ZC3H15 Gene

GeneCards Summary for ZC3H15 Gene

ZC3H15 (Zinc Finger CCCH-Type Containing 15) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ZC3H15 Gene

  • Protects DRG1 from proteolytic degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H15 Gene

Genomics for ZC3H15 Gene

Regulatory Elements for ZC3H15 Gene

Enhancers for ZC3H15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZC3H15 on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZC3H15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC3H15 Gene

Chromosome:
2
Start:
186,486,156 bp from pter
End:
186,509,363 bp from pter
Size:
23,208 bases
Orientation:
Plus strand

Genomic View for ZC3H15 Gene

Genes around ZC3H15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H15 Gene

Proteins for ZC3H15 Gene

  • Protein details for ZC3H15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU90-ZC3HF_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 15
    Protein Accession:
    Q8WU90
    Secondary Accessions:
    • B4DMW2
    • D3DPG7
    • Q5QTQ4
    • Q8WZ06
    • Q9NUZ3
    • Q9NZ37
    • Q9P079

    Protein attributes for ZC3H15 Gene

    Size:
    426 amino acids
    Molecular mass:
    48602 Da
    Quaternary structure:
    • Interacts with DRG1; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination.
    SequenceCaution:
    • Sequence=AAF28981.1; Type=Frameshift; Positions=17; Evidence={ECO:0000305}; Sequence=AAF67649.1; Type=Frameshift; Positions=392, 407, 422; Evidence={ECO:0000305}; Sequence=AAL55770.1; Type=Frameshift; Positions=92; Evidence={ECO:0000305}; Sequence=AAQ13514.1; Type=Frameshift; Positions=404, 424; Evidence={ECO:0000305};

    Alternative splice isoforms for ZC3H15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H15 Gene

Proteomics data for ZC3H15 Gene at MOPED

Post-translational modifications for ZC3H15 Gene

  • Ubiquitination at Lys 27, Lys 44, and Lys 51
  • Modification sites at PhosphoSitePlus

Other Protein References for ZC3H15 Gene

Antibody Products

No data available for DME Specific Peptides for ZC3H15 Gene

Domains & Families for ZC3H15 Gene

Gene Families for ZC3H15 Gene

Protein Domains for ZC3H15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WU90

UniProtKB/Swiss-Prot:

ZC3HF_HUMAN :
  • Belongs to the ZC3H15/TMA46 family.
  • Contains 2 C3H1-type zinc fingers.
Family:
  • Belongs to the ZC3H15/TMA46 family.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZC3H15: view

Function for ZC3H15 Gene

Molecular function for ZC3H15 Gene

UniProtKB/Swiss-Prot Function:
Protects DRG1 from proteolytic degradation.

Gene Ontology (GO) - Molecular Function for ZC3H15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZC3H15: view
genes like me logo Genes that share phenotypes with ZC3H15: view

Animal Model Products

miRNA for ZC3H15 Gene

miRTarBase miRNAs that target ZC3H15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H15 Gene

Localization for ZC3H15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H15 Gene

Cytoplasm. Nucleus. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H15 Gene COMPARTMENTS Subcellular localization image for ZC3H15 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for ZC3H15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZC3H15: view

Pathways & Interactions for ZC3H15 Gene

SuperPathways for ZC3H15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZC3H15 Gene

Drugs & Compounds for ZC3H15 Gene

No Compound Related Data Available

Transcripts for ZC3H15 Gene

Unigene Clusters for ZC3H15 Gene

Zinc finger CCCH-type containing 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3: -

Relevant External Links for ZC3H15 Gene

GeneLoc Exon Structure for
ZC3H15
ECgene alternative splicing isoforms for
ZC3H15

Expression for ZC3H15 Gene

mRNA expression in normal human tissues for ZC3H15 Gene

Protein differential expression in normal tissues from HIPED for ZC3H15 Gene

This gene is overexpressed in Lung (19.7), Cervix (12.4), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3H15 Gene



SOURCE GeneReport for Unigene cluster for ZC3H15 Gene Hs.741180

genes like me logo Genes that share expression patterns with ZC3H15: view

Protein tissue co-expression partners for ZC3H15 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H15 Gene

Orthologs for ZC3H15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZC3H15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZC3H15 35
  • 95.93 (n)
  • 98.83 (a)
ZC3H15 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H15 35
  • 94.51 (n)
  • 99 (a)
ZC3H15 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZC3H15 35
  • 99.84 (n)
  • 99.77 (a)
ZC3H15 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zc3h15 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H15 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H15 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC3H15 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h15 35
  • 74.96 (n)
  • 79.8 (a)
zebrafish
(Danio rerio)
Actinopterygii wufi40a12 35
zc3h15 35
  • 69.45 (n)
  • 76.66 (a)
zc3h15 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008634 35
  • 57.32 (n)
  • 59.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8635 35
  • 57.66 (n)
  • 57.14 (a)
CG8635 36
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F27D4.4 36
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA46 36
  • 44 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.5360 35
rice
(Oryza sativa)
Liliopsida Os.32086 35
wheat
(Triticum aestivum)
Liliopsida Ta.5934 35
Species with no ortholog for ZC3H15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ZC3H15 Gene

ENSEMBL:
Gene Tree for ZC3H15 (if available)
TreeFam:
Gene Tree for ZC3H15 (if available)

Paralogs for ZC3H15 Gene

No data available for Paralogs for ZC3H15 Gene

Variants for ZC3H15 Gene

Sequence variations from dbSNP and Humsavar for ZC3H15 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11555006 - 186,506,771(+) AGATG(A/T)AGATG reference, missense
rs1043497 - 186,508,674(+) TTTTC(A/C)CTGGA reference, missense
rs988110 -- 186,505,105(-) CTGAG(A/G)AGATG intron-variant
rs2044919 -- 186,487,856(+) AGAGC(C/T)TTCTC intron-variant, upstream-variant-2KB
rs3211121 -- 186,504,163(+) AAAAA(A/C/G)AAAGA reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for ZC3H15 Gene

Variant ID Type Subtype PubMed ID
dgv1279e1 CNV Complex 17122850
nsv459988 CNV Loss 19166990

Variation tolerance for ZC3H15 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZC3H15 Gene

Disorders for ZC3H15 Gene

Relevant External Links for ZC3H15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H15

No disorders were found for ZC3H15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H15 Gene

Publications for ZC3H15 Gene

  1. Independent stabilizations of polysomal Drg1/Dfrp1 complex and non- polysomal Drg2/Dfrp2 complex in mammalian cells. (PMID: 19819225) Ishikawa K. … Inoue J. (Biochem. Biophys. Res. Commun. 2009) 3 4 67
  2. Subtraction cloning and initial characterization of novel epo-immediate response genes. (PMID: 10880228) Gregory R.C. … Wojchowski D.M. (Cytokine 2000) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ZC3H15 Gene

Sources for ZC3H15 Gene

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