ZC3H15 Gene
protein-coding GIFtS: 47
GCID: GC02P187350
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zinc finger CCCH-type containing 15
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Aliases
for ZC3H15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger CCCH-Type Containing 151 2 | | HT0102 | | LEREPO41 2 3 | | MSTP0122 | | Likely Ortholog Of Mouse Immediate Early Response Erythropoietin 42 3 | | Zinc Finger CCCH Domain-Containing Protein 152 | | DRG Family-Regulatory Protein 12 3 | | DFRP13 |
Export aliases for ZC3H15 gene to outside databasesPrevious GC identifers: GC02P187060 GC02P179210 |
Summaries
for ZC3H15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90Function: Protects DRG1 from proteolytic degradation (By similarity)
|
Genomic Views
for ZC3H15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZC3H15 gene promoter:
Nkx3-1 Nkx3-1 v1 C/EBPalpha Nkx3-1 v2 AREB6 MEF-2A aMEF-2 NF-Y Zic3 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZC3H15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q32.1 Ensembl cytogenetic band: 2q32.1 HGNC cytogenetic band: 2q32.1ZC3H15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P187350: view genomic region
(about GC identifiers)
Start:
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187,350,883 bp from pter |
End:
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187,374,090 bp from pter |
Size:
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23,208 bases |
Orientation:
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plus strand |
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Proteins
for ZC3H15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90 (See
protein sequence)Recommended Name: Zinc finger CCCH domain-containing protein 15 Size: 426 amino acids; 48602 Da
Subunit: Interacts with DRG1; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides proteinstability to DRG1 possibly by blocking poly-ubiquitination
Subcellular location: Cytoplasm. Nucleus (By similarity). Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes
Sequence caution: Sequence=AAF28981.1; Type=Frameshift; Positions=17; Sequence=AAF67649.1; Type=Frameshift;Positions=392, 407, 422; Sequence=AAL55770.1; Type=Frameshift; Positions=92; Sequence=AAQ13514.1; Type=Frameshift;Positions=404, 424;
Secondary accessions: D3DPG7 Q5QTQ4 Q8WZ06 Q9NUZ3 Q9NZ37 Q9P079Explore the universe of human proteins at neXtProt for ZC3H15: NX_Q8WU90
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WU90
ZC3H15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060941.2
ENSEMBL proteins: ENSP00000338788 ENSP00000410981 ENSP00000407192 ENSP00000415788 ENSP00000440525
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZC3H15 for ontologies About GeneDecksing
ZC3H15 Antibody Products:
Assay Products for ZC3H15: |
Protein
Domains /
Families
for ZC3H15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZC3H15 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WU90ProtoNet protein and cluster: Q8WU90 1 Blocks protein family: IPB000571 Zn-finger
UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90Similarity: Belongs to the ZC3H15/TMA46 familySimilarity: Contains 2 C3H1-type zinc fingers |
Function
for ZC3H15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90Function: Protects DRG1 from proteolytic degradation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H15 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZC3H15 (NM_018471) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H15 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZC3H15 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ZC3H15:
|
Pathways & Interactions
for ZC3H15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3H15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/20 Interacting proteins for ZC3H15 (Q8WU902, 3 ENSP000003387884) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019221 | cytokine-mediated signaling pathway |
IEA | -- |
ZC3H15 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZC3H15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZC3H15
Search CenterWatch for drugs/clinical trials and news about ZC3H15 / ZC3HF
|
Transcripts
for ZC3H15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZC3H15 gene: NM_018471.2 Unigene Cluster for ZC3H15: Zinc finger CCCH-type containing 15 Hs.741180 [show with all ESTs]Unigene Representative Sequence: AK29861510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000337859(uc002upo.3) ENST00000421536 ENST00000437396 ENST00000477672
ENST00000481101 ENST00000468120 ENST00000496289 ENST00000498757 ENST00000445547
ENST00000544130
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H15 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZC3H15 (NM_018471) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZC3H15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H15 |
Additional cDNA sequence: AF109366.1 AF119892.2 AF147724.1 AF161421.1 AF220184.1 AF289586.1 AF462448.1 AK001901.1 AK297658.1 AK298615.1 AL049948.1 BC012336.1 BC021102.1 14 DOTS entries: DT.416259 DT.99986229 DT.100813839 DT.121034625 DT.91758211 DT.100813846 DT.75185742 DT.312650 DT.100813844 DT.416262 DT.121034664 DT.95133135 DT.100655472 DT.95154249 24/371 AceView cDNA sequences (see all 371): CA442376 CB242386 BG116547 AI828236 BU169907 BU153073 AA550976 BU685549 AV728145 BM825257 AA321996 BM911458 BM756137 BG681931 BM755848 BM989179 CA448311 BM700472 BM312246 BP371687 CR618848 BU182120 CA389493 AW467651
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H15 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZC3H15
|
Expression
for ZC3H15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZC3H15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCACTGTAC
About this image
See ZC3H15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZC3H15
SOURCE GeneReport for Unigene cluster: Hs.741180
SABiosciences Custom PCR Arrays for ZC3H15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZC3H15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZC3H15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC3H15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC3H15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H15 |
Orthologs
for ZC3H15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZC3H15 gene from 10/36 species (see all 36) About this table
ENSEMBL Gene Tree for ZC3H15 (if available)
TreeFam Gene Tree for ZC3H15 (if available) |
Paralogs
for ZC3H15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZC3H15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZC3H15 (187350883 - 187374090 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZC3H15
1 CNV: 3403 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC3H15 |
|
Disorders
/ Diseases
for ZC3H15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZC3H15 for disorders About GeneDecksing
3  diseases for ZC3H15: About MalaCardsmental disorders malaria hiv type 1
Export disorders for ZC3H15 gene to outside databases
|
Publications
for ZC3H15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZC3H15 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with ZC3H15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Independent stabilizations of polysomal Drg1/Dfrp1 co mplex and non-polysomal Drg2/Dfrp2 complex in mammalian cells. (PubMed id 19819225)1, 2 Ishikawa K....Inoue J. (2009)
- Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2. (PubMed id 15676025)1, 2 Ishikawa K.... Inoue J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Subtraction cloning and initial characterization of novel epo-immediate response genes. (PubMed id 10880228)1, 3 Gregory R.C....Wojchowski D.M. (2000)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for ZC3H15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZC3H15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZC3H15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZC3H15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZC3H15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZC3H15 gene:
Search GeneIP for patents involving ZC3H15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZC3H15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for ZC3H15 | | OriGene Custom Protein Services for ZC3H15 | | | OriGene Custom Immunoassay Development | | |
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 | | | ZC3H15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H15 |
|  |  |  | | | | ThermoFisher Antibodies for ZC3H15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H15 |
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