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Aliases for ZC3H15 Gene

Aliases for ZC3H15 Gene

  • Zinc Finger CCCH-Type Containing 15 2 3 5
  • Likely Ortholog Of Mouse Immediate Early Response Erythropoietin 4 3 4
  • DRG Family-Regulatory Protein 1 3 4
  • LEREPO4 3 4
  • Likely Ortholog Of Mouse Immediate Early Response, Erythropoietin 4 2
  • Zinc Finger CCCH Domain-Containing Protein 15 3
  • MSTP012 3
  • HT010 3
  • DFRP1 4

External Ids for ZC3H15 Gene

Previous GeneCards Identifiers for ZC3H15 Gene

  • GC02P187060
  • GC02P187350
  • GC02P179210

Summaries for ZC3H15 Gene

GeneCards Summary for ZC3H15 Gene

ZC3H15 (Zinc Finger CCCH-Type Containing 15) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ZC3H15 Gene

  • Protects DRG1 from proteolytic degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H15 Gene

Genomics for ZC3H15 Gene

Regulatory Elements for ZC3H15 Gene

Enhancers for ZC3H15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F186555 1.1 FANTOM5 4.3 +69.3 69283 0.2 CTCF GATA3 GATA2 SMC3 RAD21 ITGAV ZC3H15 ENSG00000281192
GH02F186129 0.7 Ensembl ENCODE 3.6 -355.7 -355724 1.9 ELF3 FEZF1 ZSCAN9 RARA ZNF366 SCRT2 CREM THAP11 KLF11 JUNB ENSG00000259915 MED28P3 ZC3H15 ENSG00000226410 GC02P186098
GH02F186482 0.4 ENCODE 0.8 -1.0 -981 5.6 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ITGAV ENSG00000259915 FSIP2-AS1 LOC101927196 ZC3H15 LOC105373785
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZC3H15 on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000305730 144 4201 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for ZC3H15 Gene

Chromosome:
2
Start:
186,486,156 bp from pter
End:
186,509,363 bp from pter
Size:
23,208 bases
Orientation:
Plus strand

Genomic View for ZC3H15 Gene

Genes around ZC3H15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H15 Gene

Proteins for ZC3H15 Gene

  • Protein details for ZC3H15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU90-ZC3HF_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 15
    Protein Accession:
    Q8WU90
    Secondary Accessions:
    • B4DMW2
    • D3DPG7
    • Q5QTQ4
    • Q8WZ06
    • Q9NUZ3
    • Q9NZ37
    • Q9P079

    Protein attributes for ZC3H15 Gene

    Size:
    426 amino acids
    Molecular mass:
    48602 Da
    Quaternary structure:
    • Interacts with DRG1; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination.
    SequenceCaution:
    • Sequence=AAF28981.1; Type=Frameshift; Positions=17; Evidence={ECO:0000305}; Sequence=AAF67649.1; Type=Frameshift; Positions=392, 407, 422; Evidence={ECO:0000305}; Sequence=AAL55770.1; Type=Frameshift; Positions=92; Evidence={ECO:0000305}; Sequence=AAQ13514.1; Type=Frameshift; Positions=404, 424; Evidence={ECO:0000305};

    Alternative splice isoforms for ZC3H15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H15 Gene

Post-translational modifications for ZC3H15 Gene

  • Ubiquitination at Lys 27, Lys 44, and Lys 51
  • Modification sites at PhosphoSitePlus

Other Protein References for ZC3H15 Gene

No data available for DME Specific Peptides for ZC3H15 Gene

Domains & Families for ZC3H15 Gene

Gene Families for ZC3H15 Gene

Protein Domains for ZC3H15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WU90

UniProtKB/Swiss-Prot:

ZC3HF_HUMAN :
  • Belongs to the ZC3H15/TMA46 family.
  • Contains 2 C3H1-type zinc fingers.
Family:
  • Belongs to the ZC3H15/TMA46 family.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZC3H15: view

Function for ZC3H15 Gene

Molecular function for ZC3H15 Gene

UniProtKB/Swiss-Prot Function:
Protects DRG1 from proteolytic degradation.

Gene Ontology (GO) - Molecular Function for ZC3H15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19819225
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with ZC3H15: view
genes like me logo Genes that share phenotypes with ZC3H15: view

Animal Model Products

miRNA for ZC3H15 Gene

miRTarBase miRNAs that target ZC3H15

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H15 Gene

Localization for ZC3H15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H15 Gene

Cytoplasm. Nucleus. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H15 Gene COMPARTMENTS Subcellular localization image for ZC3H15 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for ZC3H15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with ZC3H15: view

Pathways & Interactions for ZC3H15 Gene

SuperPathways for ZC3H15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ZC3H15: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H15 Gene

Transcripts for ZC3H15 Gene

Unigene Clusters for ZC3H15 Gene

Zinc finger CCCH-type containing 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3: -

Relevant External Links for ZC3H15 Gene

GeneLoc Exon Structure for
ZC3H15
ECgene alternative splicing isoforms for
ZC3H15

Expression for ZC3H15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZC3H15 Gene

Protein differential expression in normal tissues from HIPED for ZC3H15 Gene

This gene is overexpressed in Lung (19.7), Cervix (12.4), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC3H15 Gene



Protein tissue co-expression partners for ZC3H15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC3H15 Gene:

ZC3H15

SOURCE GeneReport for Unigene cluster for ZC3H15 Gene:

Hs.741180
genes like me logo Genes that share expression patterns with ZC3H15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H15 Gene

Orthologs for ZC3H15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZC3H15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H15 34 35
  • 99.84 (n)
mouse
(Mus musculus)
Mammalia Zc3h15 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZC3H15 34 35
  • 95.93 (n)
dog
(Canis familiaris)
Mammalia ZC3H15 34 35
  • 94.51 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H15 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H15 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC3H15 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h15 34
  • 74.96 (n)
zebrafish
(Danio rerio)
Actinopterygii zc3h15 34 35
  • 69.45 (n)
wufi40a12 34
fruit fly
(Drosophila melanogaster)
Insecta CG8635 34 35
  • 57.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008634 34
  • 57.32 (n)
worm
(Caenorhabditis elegans)
Secernentea F27D4.4 35
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA46 35
  • 44 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.5360 34
rice
(Oryza sativa)
Liliopsida Os.32086 34
wheat
(Triticum aestivum)
Liliopsida Ta.5934 34
Species where no ortholog for ZC3H15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ZC3H15 Gene

ENSEMBL:
Gene Tree for ZC3H15 (if available)
TreeFam:
Gene Tree for ZC3H15 (if available)

Paralogs for ZC3H15 Gene

No data available for Paralogs for ZC3H15 Gene

Variants for ZC3H15 Gene

Sequence variations from dbSNP and Humsavar for ZC3H15 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10164423 -- 186,504,006(+) CCACC(A/G)CTTGT intron-variant
rs10172850 -- 186,494,617(+) TCCCA(A/G)TATAA intron-variant
rs10190003 -- 186,492,738(+) TCTAG(C/T)TTGTC intron-variant
rs10198525 -- 186,491,078(+) CAAAT(C/T)GCAAA intron-variant
rs1043497 -- 186,508,674(+) TTTTC(A/C)CTGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZC3H15 Gene

Variant ID Type Subtype PubMed ID
esv2759107 CNV gain 17122850
esv3593670 CNV loss 21293372
nsv459988 CNV loss 19166990
nsv584031 CNV loss 21841781

Variation tolerance for ZC3H15 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H15 Gene

Disorders for ZC3H15 Gene

Relevant External Links for ZC3H15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H15

No disorders were found for ZC3H15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H15 Gene

Publications for ZC3H15 Gene

  1. Independent stabilizations of polysomal Drg1/Dfrp1 complex and non- polysomal Drg2/Dfrp2 complex in mammalian cells. (PMID: 19819225) Ishikawa K. … Inoue J. (Biochem. Biophys. Res. Commun. 2009) 3 4 64
  2. Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2. (PMID: 15676025) Ishikawa K. … Inoue J. (Genes Cells 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Subtraction cloning and initial characterization of novel epo-immediate response genes. (PMID: 10880228) Gregory R.C. … Wojchowski D.M. (Cytokine 2000) 2 3 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for ZC3H15 Gene

Sources for ZC3H15 Gene

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