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ZC3H15 Gene

protein-coding   GIFtS: 48
GCID: GC02P187350

Zinc Finger CCCH-Type Containing 15

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger CCCH-Type Containing 151 2     Likely Ortholog Of Mouse Immediate Early Response1
Likely Ortholog Of Mouse Immediate Early Response Erythropoietin 42 3     HT0102
LEREPO42 3     MSTP0122
DRG Family-Regulatory Protein 12 3     Zinc Finger CCCH Domain-Containing Protein 152
Erythropoietin 41     DFRP13

External Ids:    HGNC: 295281   Entrez Gene: 558542   Ensembl: ENSG000000655487   UniProtKB: Q8WU903   

Export aliases for ZC3H15 gene to outside databases

Previous GC identifers: GC02P187060 GC02P179210


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZC3H15 Gene:
ZC3H15 (zinc finger CCCH-type containing 15) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90
Function: Protects DRG1 from proteolytic degradation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZC3H15 gene promoter:
         Nkx3-1   Nkx3-1 v1   C/EBPalpha   Nkx3-1 v2   AREB6   MEF-2A   aMEF-2   NF-Y   Zic3   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC3H15 promoter sequence
   Search Chromatin IP Primers for ZC3H15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZC3H15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q32.1

ZC3H15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3H15 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P187350:  view genomic region     (about GC identifiers)

Start:
187,350,883 bp from pter      End:
187,374,090 bp from pter
Size:
23,208 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 15  
Size: 426 amino acids; 48602 Da
Subunit: Interacts with DRG1; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein
stability to DRG1 possibly by blocking poly-ubiquitination
Sequence caution: Sequence=AAF28981.1; Type=Frameshift; Positions=17; Sequence=AAF67649.1; Type=Frameshift;
Positions=392, 407, 422; Sequence=AAL55770.1; Type=Frameshift; Positions=92; Sequence=AAQ13514.1;
Type=Frameshift; Positions=404, 424;
Secondary accessions: D3DPG7 Q5QTQ4 Q8WZ06 Q9NUZ3 Q9NZ37 Q9P079

Explore the universe of human proteins at neXtProt for ZC3H15: NX_Q8WU90

Explore proteomics data for ZC3H15 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys27, Lys44, Lys51
  • Modification sites at PhosphoSitePlus

  • See ZC3H15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060941.2  
    ENSEMBL proteins: 
     ENSP00000338788   ENSP00000410981   ENSP00000407192   ENSP00000415788   ENSP00000440525  

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    Cloud-Clone Corp. Proteins for ZC3H15

     
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    antibodies-online proteins for ZC3H15 (8 products) 

     
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    antibodies-online kits for ZC3H15 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC3H: Zinc fingers, CCCH-type domain containing

    1 InterPro protein domain:
     IPR000571 Znf_CCCH

    Graphical View of Domain Structure for InterPro Entry Q8WU90

    ProtoNet protein and cluster: Q8WU90

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90
    Similarity: Belongs to the ZC3H15/TMA46 family
    Similarity: Contains 2 C3H1-type zinc fingers


    Find genes that share domains with ZC3H15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZC3HF_HUMAN, Q8WU90
    Function: Protects DRG1 from proteolytic degradation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19819225
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZC3H15           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZC3H15:
     Decreased viability with pacli  Increased Hepatitis C virus re  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZC3H15

    miRNA
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    miRTarBase miRNAs that target ZC3H15:
    hsa-mir-186-5p (MIRT021112), hsa-mir-96-5p (MIRT027880)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZC3HF_HUMAN, Q8WU90: Cytoplasm. Nucleus (By similarity). Note=The DRG1-DFRP2/ZC3H15 complex associates with
    polysomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with ZC3H15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZC3H15
    Interactions:

        Search GeneGlobe Interaction Network for ZC3H15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZC3H15 (Q8WU902, 3 ENSP000003387884) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C8orf33Q9H7E92, 3MINT-8250578 I2D: score=2 
    TNNT1P138052, 3MINT-8275127 I2D: score=2 
    DRG1Q9Y2953, ENSP000003297154I2D: score=4 STRING: ENSP00000329715
    ABCF3Q9NUQ83, ENSP000004114714I2D: score=1 STRING: ENSP00000411471
    ABCF2Q9UG633, ENSP000002223884I2D: score=1 STRING: ENSP00000222388
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019221cytokine-mediated signaling pathway IEA--

    Find genes that share ontologies with ZC3H15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZC3H15 (ZC3HF)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZC3H15 gene: 
    NM_018471.2  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337859(uc002upo.3) ENST00000421536 ENST00000437396 ENST00000477672
    ENST00000481101 ENST00000468120 ENST00000496289 ENST00000498757 ENST00000445547
    ENST00000544130
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZC3H15
      QuantiFast Probe-based Assays in human, mouse, rat ZC3H15

    Selected AceView cDNA sequences (see all 371):

    CK905974 BM668740 AU139078 AK001901 CR618848 BM802250 BE550402 BM755848 
    BM561355 BM556391 BM693462 BU153073 AW575711 BC012336 BM996526 AA328380 
    AA448883 BP371687 BM788314 CA441236 AI825360 CA448311 BM700472 AW467651 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H15    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:                                                                        
    SP3:              -                                                         


    ECgene alternative splicing isoforms for ZC3H15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZC3H15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCACTGTAC
    ZC3H15 Expression
    About this image


    ZC3H15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    ZC3H15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZC3H15 Protein Expression
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZC3H15 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc3h155 zinc finger CCCH-type containing 15   --   2 (49.33 cM) 83644435 
    chicken
    (Gallus gallus)
    Aves ZC3H156
    Gallus gallus zinc finger CCCH-type containing 15 ...
    86(a)
    1 ↔ 1
    7(1350019-1362150)
    lizard
    (Anolis carolinensis)
    Reptilia ZC3H156
    zinc finger CCCH-type containing 15
    89(a)
    1 ↔ 1
    GL343737.1(4186-11884)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA787825.12   -- 78.51(n)    CA787825.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi40a122 wufi40a12 73.15(n)   334307  BC044451.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86351 CG8635 57.66(n)
    57.14(a)
      35850  NM_136557.2  NP_610401.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F27D4.46
    Protein F27D4.4, isoform b (F27D4.4) mRNA, complet...
    49(a)
    1 ↔ 1
    I(7725019-7727113) WBGene00009189
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TMA466
    Protein of unknown function that associates with t...
    44(a)
    1 ↔ 1
    XV(493433-494470) YOR091W
    rice
    (Oryza sativa)
    Liliopsida Os.320862 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.97(n)    AK101559.1 


    ENSEMBL Gene Tree for ZC3H15 (if available)
    TreeFam Gene Tree for ZC3H15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZC3H15 (see all 463)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146294811,2
    --187348964(+) CCTTGG/TACTAT 1 -- us2k10--------
    rs13767811,2
    C,F,O,H--187348984(+) GCACTG/CTTTTG 1 -- us2k123Minor allele frequency- C:0.16NA NS EA 2790
    rs1912509701,2
    --187349003(+) TCGTTC/TGAATT 1 -- us2k10--------
    rs124730761,2
    C,F,A,H--187349063(+) TACCAT/CTTGCT 1 -- us2k127Minor allele frequency- C:0.34NA NS EA WA CSA 2664
    rs1175533491,2
    F--187349109(+) AAAAGT/CAGTGA 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1829952981,2
    --187349273(+) GAAAAA/TACCGA 1 -- us2k10--------
    rs1450213181,2
    --187349310(+) TTATGA/CACCAT 1 -- us2k10--------
    rs1126956781,2
    C--187349334(+) TATCAT/-TAACA 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1884373631,2
    --187349345(+) TTATGA/GGACTC 1 -- us2k10--------
    rs1906857981,2
    --187349416(+) TCAGTA/GAAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZC3H15 (187350883 - 187374090 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZC3H15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv459988CNV Loss19166990
    dgv1279e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZC3H15 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with ZC3H15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Independent stabilizations of polysomal Drg1/Dfrp1 complex and non- polysomal Drg2/Dfrp2 complex in mammalian cells. (PubMed id 19819225)1, 2 Ishikawa K.... Inoue J. (Biochem. Biophys. Res. Commun. 2009)
    2. Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2. (PubMed id 15676025)1, 2 Ishikawa K.... Inoue J. (Genes Cells 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Subtraction cloning and initial characterization of novel epo-immediate response genes. (PubMed id 10880228)1, 3 Gregory R.C....Wojchowski D.M. (Cytokine 2000)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFI_B pathway and overexpressed in AML. (PubMed id 23624947)1 Capalbo G....Scheuring U.J. (Int. J. Oncol. 2013)
    7. Human Drg1 is a potassium-dependent GTPase enhanced by Lerepo4. (PubMed id 23711155)1 PAcrez-Arellano I....Bravo J. (FEBS J. 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55854 HGNC: 29528 AceView: LEREPO4 Ensembl:ENSG00000065548 euGenes: HUgn55854
    ECgene: ZC3H15 H-InvDB: ZC3H15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZC3H15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZC3H15 gene:
    Search GeneIP for patents involving ZC3H15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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