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ZC3H15 Gene

protein-coding   GIFtS: 43

GC02P187060
zinc finger CCCH-type containing 15
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DFRP1 3
HT010 2
LEREPO4 1, 2, 3
MSTP012 2
Descriptions
DRG family-regulatory protein 1 3
Likely ortholog of mouse immediate early response
erythropoietin 4 3
erythropoietin 4 immediate early response 2
zinc finger CCCH-type containing 15 2
External Ids
HGNC: 295281
Entrez Gene: 558542
UniProtKB: Q8WU903
Ensembl: ENSG000000655487
Search outside databases for aliases for ZC3H15 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90
Function: Protects DRG1 from proteolytic degradation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q32.1

ZC3H15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P187060:     (about GC identifiers)

Start:
187,059,130 bp from pter
End:
187,082,333 bp from pter
Size:
23,204 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 15  
Size: 426 amino acids; 48602 Da
Subunit: Interacts with DRG1
Subcellular location: Cytoplasm. Nucleus (By similarity)
Sequence caution: Sequence=AAF28981.1; Type=Frameshift; Positions=17; Sequence=AAF67649.1;
Type=Frameshift; Positions=392, 407, 422; Sequence=AAL55770.1; Type=Frameshift; Positions=92;
Sequence=AAQ13514.1; Type=Frameshift; Positions=404, 424;
Secondary accessions: Q5QTQ4 Q8WZ06 Q9NUZ3 Q9NZ37 Q9P079

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_060941.2  

    ENSEMBL proteins: 
    ENSP00000338788 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (LEREPO4)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for ZC3H15: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZC3H15
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ZC3H15

    Assays for ZC3H15: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR000571 Znf_CCCH


       GeneDecks  ZC3H15 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8WU90

    ProtoNet protein and cluster: Q8WU90

    1 Blocks protein family: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90
    Similarity: Belongs to the ZC3H15/TMA46 family
    Similarity: Contains 2 C3H1-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZC3H15)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (LEREPO4)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018471

                  Applied Biosystems Silencer® siRNAs for ZC3H15

                  Sigma-Aldrich siRNA for ZC3H15  
                         Sigma-Aldrich shRNA for ZC3H15  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ZC3H15
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018471
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018471
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_018471 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_018471

    UniProtKB/Swiss-Prot: ZC3HF_HUMAN, Q8WU90
    Function: Protects DRG1 from proteolytic degradation (By similarity)

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019221 cytokine-mediated signaling pathway IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZC3H15

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZC3H15)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (LEREPO4)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018471

                  Sigma-Aldrich siRNA for ZC3H15  
                         Sigma-Aldrich shRNA for ZC3H15  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_018471  

    REFSEQ mRNAs for ZC3H15 gene: 

    NM_018471.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_018471  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018471
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018471
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_018471 

    Additional cDNA sequence: 

    AF109366.1 AF119892.1 AF147724.1 AF161421.1 AF220184.1 AF289586.1 AF462448.1 AK001901.1 
    AK297658.1 AK298615.1 AL049948.1 BC012336.1 BC021102.1 CR601058.1 CR601257.1 CR618848.1 
    CR622467.1 

    14 DOTS entries:

    DT.416259  DT.99986229  DT.100813839  DT.121034625  DT.91758211  DT.100813846  DT.75185742  DT.312650 
    DT.100813844  DT.416262  DT.95133135  DT.121034664  DT.100655472  DT.95154249 

    24/371 AceView cDNA sequences (see all 371 ):

    BM843205 AI828236 BC012336 AV728145 CA312375 BP371687 BM561991 BU169907 
    AA550976 BE676044 AI340331 BQ776270 CR622467 BU508199 BM825257 BQ434138 
    BU685549 BM757597 BM911458 AI653869 BQ433362 BM556391 BU182120 BC021102 

    highest scoring ESTs for ZC3H15:

    AA054718 AA056989 AA057864 AA102512 AA205953 AA448883 AA558954 AA670250 AF147724 AF161421 

    Unigene Cluster for ZC3H15:

    Zinc finger CCCH-type containing 15
    Hs.368598  [show with all ESTs]
    Unigene Representative Sequence: AK298615


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H15

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:                                                                        
    SP3:              -                                                         

    About this scheme

    ECgene alternative splicing isoforms for ZC3H15

    1 Ensembl transcript including schematic representation:
    ENST00000337859  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZC3H15 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H15

    1 / 2 / 3

    5 probe-sets matching ZC3H15 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35750_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AL049948 0.80 1.00 0.91 1

    201595_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018471 0.60 1.00 0.82 1

    201593_s_at2, 3 U133-A 1 1.00 1.00 -- -- AV716798 0.60 1.00 0.82 1

    201595_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    201593_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ZC3H15 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.368598
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZC3H15 gene from 5/24 species (see all 24 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZC3H151   -- zinc finger CCCH-type containing 15 94.51(n)
    99(a)
    478831  XM_535993.2  XP_535993.2 
    chimpanzee
    (Pan troglodytes)
    ZC3H151   -- zinc finger CCCH-type containing 15 99.84(n)
    99.77(a)
    459805  XM_515965.2  XP_515965.2 
    cow
    (Bos taurus)
    ZC3H151   -- zinc finger CCCH-type containing 15 95.93(n)
    98.83(a)
    535102  NM_001046394.1  NP_001039859.1 
    rat
    (Rattus norvegicus)
    Zc3h151   -- zinc finger CCCH-type containing 15 90.3(n)
    96.48(a)
    362154  NM_001010963.1  NP_001010963.1 
    mouse
    (Mus musculus)
    Zc3h151, 5 25
    zinc finger CCCH-type containing 151, 5 91.08(n)1
    95.54(a)1
    690821  NM_026934.31  NP_081210.21 
     AA6365445  AF2218515  (see all 28)
    About this table        Species with no ortholog for ZC3H15

    ENSEMBL Gene Tree for ZC3H15
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/98 NCBI SNPs in ZC3H15 are shown (see all 98 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 60)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs14518741,2
    A,C,F,H,O187058486(+) GAAATA/GGTGTG 1 -- ng517Minor allele frequency- G:0.39EU EA WA NA 560
    rs124730761,2
    A,C,F,H187057308(+) TACCAT/CTTGCT 1 -- ng5111Minor allele frequency- C:0.37NA EU EA WA 914
    rs13767811,2
    C,F,H,O187057229(+) GCACTG/CTTTTG 1 -- ng5111Minor allele frequency- C:0.16NA EU EA WA 970
    rs37545821,2
    C,F,H187058224(+) AAGCAT/CTGTAC 1 -- ng517Minor allele frequency- C:0.19NA EU EA WA 562
    rs168279481,2
    F,H187081968(+) CCACCC/TAAGTA 1 -- ut31 ese37Minor allele frequency- T:0.00NA EU EA WA 562
    --
    rs115550061,2
    H187079743(+) AGATGT/AAGATG 1 E/V mis1 ese34Minor allele frequency- A:0.00EU EA WA 406
    --
    rs283658151,2
    F187059131(+) AGTGGG/-CGCGC 1 -- ut512Minor allele frequency- -:0.34MN EA 1252
    rs133950191,2
    H187082501(+) AAGCTT/CCCAAA 1 -- ng314Minor allele frequency- C:0.00EU EA WA 418
    rs10434971,2
    H187081646(+) TTTTCA/CCTGGA 1 T/P mis1 ese35Minor allele frequency- C:0.00MN EU EA WA 590
    rs20449191,2
    A,C,F,O187060828(+) AGAGCC/TTTCTC 1 -- int13Minor allele frequency- T:0.41NA 142
    About this table

    HapMap Linkage Disequilibrium images for ZC3H15 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10 PubMed articles for ZC3H15 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55854 HGNC: 29528 AceView: LEREPO4 Ensembl:ENSG00000065548 euGenes: HUgn55854
    ECgene: ZC3H15 H-InvDB: ZC3H15
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZC3H15:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZC3H15-related products

     Millipore Custom Antibody & Bulk Services
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     Predesigned and custom siRNAs for ZC3H15 Antibodies for ZC3H15
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZC3H15 Browse small molecules at Sigma-Aldrich
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     Search Novus for antibodies for ZC3H15

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