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ZC3H14 Gene

protein-coding   GIFtS: 51

GC14P088100
zinc finger CCCH-type containing 14
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ11806 1, 2
MGC26892 2
NY-REN-37 1, 2
UKp68 1, 2
Descriptions
Renal carcinoma antigen NY-REN-37 3
nuclear protein UKp68 2
zinc finger CCCH-type containing 14 2
External Ids
HGNC: 205091
Entrez Gene: 798822
UniProtKB: Q6PJT73
Ensembl: ENSG000001007227
Search outside databases for aliases for ZC3H14 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZC3HE_HUMAN, Q6PJT7
Function: Binds the polyadenosine RNA oligonucleotides

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZC3H14 gene  

Entrez Gene cytogenetic band: 14q31.3   Ensembl cytogenetic band:  14q31.3   HGNC cytogenetic band: 14q31.3

ZC3H14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P088100:     (about GC identifiers)

Start:
88,099,067 bp from pter
End:
88,158,368 bp from pter
Size:
59,302 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZC3HE_HUMAN, Q6PJT7 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 14  
Size: 736 amino acids; 82876 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAL83289.1; Type=Miscellaneous discrepancy; Note=Several sequencing
errors; Sequence=AAS90302.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors;
Sequence=AK021868; Type=Frameshift; Positions=199;
Secondary accessions: A8MY46 Q6MZU4 Q6PJ32 Q6PUI6 Q6PUI8 Q86TQ5 Q86TW0 Q86TW1 Q8NCT6 Q8NCZ3 Q8TDE2
Q9HAC9 Q9Y5A0
Alternative splicing: 8 isoforms:  Q6PJT7-1   Q6PJT7-2   Q6PJT7-3   Q6PJT7-4   Q6PJT7-5   Q6PJT7-6   Q6PJT7-7   Q6PJT7-8   

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (6 alternative transcripts): 
    NP_001153575.1  NP_001153576.1  NP_079100.2  NP_997543.1  NP_997544.1  NP_997545.2  


    ENSEMBL proteins: 
    ENSP00000377164 ENSP00000251038 ENSP00000307025 ENSP00000352250 ENSP00000338002 ENSP00000384682 
    ENSP00000377150 ENSP00000327176 ENSP00000370059 ENSP00000251037 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZC3H14)
    Human Recombinant Proteins from Abnova (FLJ11806)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZC3H14: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZC3H14
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZC3H14), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (FLJ11806)
    Novus Biologicals Antibodies for ZC3H14

    Assays for ZC3H14: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR000571 Znf_CCCH


       GeneDecks  ZC3H14 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6PJT7

    ProtoNet protein and cluster: Q6PJT7

    1 Blocks protein family: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: ZC3HE_HUMAN, Q6PJT7
    Similarity: Belongs to the ZC3H14 family
    Similarity: Contains 2 C3H1-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZC3H14)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FLJ11806)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): BC027607

                  Applied Biosystems Silencer® siRNAs for ZC3H14

                  Sigma-Aldrich siRNA for ZC3H14  
                         Sigma-Aldrich shRNA for ZC3H14  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ZC3H14
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_024824
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_024824
                                     untagged cDNA clones in CMV expression vector (see all 5): BC027607 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_024824

    UniProtKB/Swiss-Prot: ZC3HE_HUMAN, Q6PJT7
    Function: Binds the polyadenosine RNA oligonucleotides

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for ZC3H14 (ENSP000002510383) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C14orf143ENSP000003262673STRING (score=.706)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZC3H14

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZC3H14)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FLJ11806)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): BC027607

                  Sigma-Aldrich siRNA for ZC3H14  
                         Sigma-Aldrich shRNA for ZC3H14  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_024824  NM_207660  NM_207661  NM_207662  

    REFSEQ mRNAs for ZC3H14 gene (6 alternative transcripts): 

    NM_001160103.1   NM_001160104.1   NM_024824.4   NM_207660.3   NM_207661.2   NM_207662.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_024824  NM_207660  NM_207661  NM_207662  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_024824
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_024824
                                     untagged cDNA clones in CMV expression vector (see all 5): BC027607 

    Additional cDNA sequence: 

    AF086083.1 AF155107.1 AF474376.1 AK021868.1 AK090809.1 AK302136.1 AK303123.1 AK304275.1 
    AL359625.1 AL834215.1 AY578060.1 AY578061.1 AY578062.1 AY578063.1 BC011793.1 BC023641.2 
    BC027607.2 BC034274.1 BX248265.1 BX248281.1 BX248769.1 BX640716.1 BX640876.1 

    22 DOTS entries:

    DT.95187202  DT.95187208  DT.97808871  DT.99991930  DT.95187224  DT.100036903  DT.100791097  DT.101984724 
    DT.120750366  DT.95187756  DT.100036904  DT.40208088  DT.95187219  DT.95187225  DT.97847515  DT.100756450 
    DT.100786344  DT.100842122  DT.120750370  DT.92440508  DT.120750365  DT.91664110 

    24/348 AceView cDNA sequences (see all 348 ):

    AI373666 AI143388 BE045438 CF242889 BC023641 AA741479 BG569535 BF477379 
    CA426551 AI201309 AU119634 AA455182 N67843 AA910410 BM855409 BM766255 
    BF131543 BX640716 AI090924 R92889 AA233647 CA866623 BQ427901 BX248769 

    highest scoring ESTs for ZC3H14:

    AI561196 AA233551 AA233636 AA233647 AA233666 AA280736 AA443473 AA446535 AA448862 AA455182 

    Unigene Cluster for ZC3H14:

    Zinc finger CCCH-type containing 14
    Hs.325846  [show with all ESTs]
    Unigene Representative Sequence: NM_024824


    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H14 (see all 21 )

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
    SP1:                          -     -           -                                                                                         -     -     -         
    SP2:                                -           -                                                                                         -     -     -         
    SP3:                          -     -           -                                                                                         -     -     -     -   
    SP4:                                                                                                                                      -     -     -         
    SP5:                                                                                                                                                            

    ExUns: 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18 ^ 19 ^ 20a · 20b · 20c
    SP1:                                                  -                 -                                 
    SP2:  -     -     -     -     -     -                 -                 -                                 
    SP3:  -     -     -     -     -     -                 -                 -                                 
    SP4:                                                  -                 -                                 
    SP5:  -     -     -     -     -     -                 -                 -                                 

    About this scheme

    ECgene alternative splicing isoforms for ZC3H14

    10 Ensembl transcripts including schematic representations:
    ENST00000393530  ENST00000251038  ENST00000302216  ENST00000359301  ENST00000336693  ENST00000406216  
    ENST00000393514  ENST00000318308  ENST00000380684  ENST00000353091  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZC3H14 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H14

    1 / 2 / 3

    7 probe-sets matching ZC3H14 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40859_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AI561196 1.00 1.00 1.00 1

    213063_at2, 3 U133-A 1 1.00 1.00 -- -- BF970253 0.60 0.75 0.68 1

    204216_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024824 0.60 1.00 0.82 1

    213064_at2, 3 U133-A 1 1.00 1.00 -- -- N64802 0.80 1.00 0.91 1

    213063_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    204216_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    213064_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ZC3H14 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TACTGATGAA

    SOURCE GeneReport for Unigene cluster: Hs.325846
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZC3H14 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZC3H141   -- zinc finger CCCH-type containing 14 93.89(n)
    94.8(a)
    480412  XM_849256.1  XP_854349.1 
    rat
    (Rattus norvegicus)
    Zc3h141   -- zinc finger CCCH type containing 14 90.85(n)
    89.67(a)
    192359  NM_001033951.1  NP_001029123.1 
    mouse
    (Mus musculus)
    Zc3h141, 5 125
    zinc finger CCCH type containing 141, 5 90.57(n)1
    89.8(a)1
    755531  NM_029334.11  NP_083610.11 
     AI1974315  AK0060095  (see all 33)
    chicken
    (Gallus gallus)
    ZC3H141   -- zinc finger CCCH-type containing 14 72.36(n)
    72.04(a)
    423399  NM_001012586.1  NP_001012604.1 
    zebrafish
    (Danio rerio)
    Dr.135702   -- Transcribed sequence with weak similarity to protein more 74.42(n)  BM316027.1 
    About this table        Species with no ortholog for ZC3H14

    ENSEMBL Gene Tree for ZC3H14
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/247 NCBI SNPs in ZC3H14 are shown (see all 247 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 55)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs111598591,2
    A,C,F,H88097644(+) ctctaC/Ggactt 3 -- ng514Minor allele frequency- G:0.46EU EA WA 420
    --
    rs80088471,2
    C,F,H88148680(+) CATATG/ATATTC 4 -- ut31 ese33Minor allele frequency- A:0.01EU EA 296
    --
    rs80206921,2
    C88129253(+) agagaC/Tgggat 4 -- ng51 int10--------
    --
    rs115561051,2
    H88104192(+) AGGACC/AAAATG 3 K/Q mis1 ese34Minor allele frequency- A:0.00EU EA WA 406
    rs38256751,2
    H88149454(-) ATTTAA/GAATAA 4 -- ut314Minor allele frequency- G:0.00EU EA WA 418
    rs171247851,2
    F,H88110891(+) GATTAC/TGGGTC 3 Y/Y syn1 ese37Minor allele frequency- T:0.01NA EU EA WA 562
    rs118491181,2
    H88108861(+) TATGGT/GTCTTC 3 G/G syn14Minor allele frequency- G:0.00EU EA WA 420
    rs20529871,2
    A,C,F,H88147607(+) TGGGAA/GATACT 4 -- int112Minor allele frequency- G:0.06NA EA EU 877
    rs101444751,2
    A,C,F,H88105824(+) CTTGCC/GTTTAT 3 -- int18Minor allele frequency- G:0.25EU EA WA NA 774
    --
    rs116285451,2
    A,C,F,H88142791(+) ATTACA/GCCACT 4 -- int14Minor allele frequency- G:0.50EU EA WA 410
    About this table

    HapMap Linkage Disequilibrium images for ZC3H14 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/15 PubMed articles for ZC3H14 gene (see all 15 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 79882 HGNC: 20509 AceView: FLJ11806 Ensembl:ENSG00000100722 euGenes: HUgn79882
    ECgene: ZC3H14 H-InvDB: ZC3H14
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZC3H14:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZC3H14-related products

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     Millipore Preclinical / Clinical Development Services
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     Predesigned and custom siRNAs for ZC3H14 Antibodies for ZC3H14
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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     Antibodies for ZC3H14

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