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Aliases for ZC3H14 Gene

Aliases for ZC3H14 Gene

  • Zinc Finger CCCH-Type Containing 14 2 3
  • Mammalian Suppressor Of Tau Pathology-2 3 4
  • Renal Carcinoma Antigen NY-REN-37 3 4
  • MSUT-2 3 4
  • SUT2 3 6
  • Zinc Finger CCCH Domain-Containing Protein 14 3
  • Nuclear Protein UKp68 3
  • NY-REN-37 3
  • UKp68 3

External Ids for ZC3H14 Gene

Summaries for ZC3H14 Gene

Entrez Gene Summary for ZC3H14 Gene

  • ZC3H14 belongs to a family of poly(A)-binding proteins that influence gene expression by regulating mRNA stability, nuclear export, and translation (Kelly et al., 2007 [PubMed 17630287]).[supplied by OMIM, Mar 2010]

GeneCards Summary for ZC3H14 Gene

ZC3H14 (Zinc Finger CCCH-Type Containing 14) is a Protein Coding gene. Diseases associated with ZC3H14 include autosomal recessive non-syndromic intellectual disability. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for ZC3H14 Gene

  • Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H14 Gene

Genomics for ZC3H14 Gene

Genomic Location for ZC3H14 Gene

Start:
88,562,909 bp from pter
End:
88,627,596 bp from pter
Size:
64,688 bases
Orientation:
Plus strand

Genomic View for ZC3H14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZC3H14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H14 Gene

Regulatory Elements for ZC3H14 Gene

Proteins for ZC3H14 Gene

  • Protein details for ZC3H14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJT7-ZC3HE_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 14
    Protein Accession:
    Q6PJT7
    Secondary Accessions:
    • A8MY46
    • B4DXU8
    • B4DZW7
    • B4E2H4
    • G3V5R4
    • Q6MZU4
    • Q6PJ32
    • Q6PUI6
    • Q6PUI8
    • Q86TQ5
    • Q86TW0
    • Q86TW1
    • Q8NCT6
    • Q8NCZ3
    • Q8TDE2
    • Q9HAC9
    • Q9Y5A0

    Protein attributes for ZC3H14 Gene

    Size:
    736 amino acids
    Molecular mass:
    82876 Da
    Quaternary structure:
    • Interacts with HOOK2.
    Miscellaneous:
    • ZC3H14 can functionally substitute for Nab2 in fly neurons and can rescue defects in development and locomotion that are present in dNab2 null flies
    SequenceCaution:
    • Sequence=AAL83289.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=AAS90302.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAS90302.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AK021868; Type=Frameshift; Positions=199; Evidence={ECO:0000305}; Sequence=CAE45933.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZC3H14 Gene

neXtProt entry for ZC3H14 Gene

Proteomics data for ZC3H14 Gene at MOPED

Post-translational modifications for ZC3H14 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys99, Lys139, Lys245, Lys283, Lys368, Lys378, Lys413, Lys489, Lys623, and Lys728

No data available for DME Specific Peptides for ZC3H14 Gene

Domains for ZC3H14 Gene

Gene Families for ZC3H14 Gene

HGNC:
  • ZC3H :Zinc fingers, CCCH-type domain containing

Protein Domains for ZC3H14 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ZC3HE_HUMAN
Family:
  • Belongs to the ZC3H14 family.:
    • Q6PJT7
Similarity:
  • Contains 5 C3H1-type zinc fingers.:
    • Q6PJT7
genes like me logo Genes that share domains with ZC3H14: view

Function for ZC3H14 Gene

Molecular function for ZC3H14 Gene

UniProtKB/Swiss-Prot Function: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.

Gene Ontology (GO) - Molecular Function for ZC3H14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19273536
GO:0008143 poly(A) binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H14: view

miRNA for ZC3H14 Gene

miRTarBase miRNAs that target ZC3H14

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZC3H14 Gene

Localization for ZC3H14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H14 Gene

Nucleus speckle.
Isoform 1: Nucleus speckle.
Isoform 3: Nucleus speckle.
Isoform 6: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H14 Gene COMPARTMENTS Subcellular localization image for ZC3H14 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZC3H14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with ZC3H14: view

Pathways for ZC3H14 Gene

SuperPathways for ZC3H14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043488 regulation of mRNA stability IBA --
GO:1900364 negative regulation of mRNA polyadenylation IBA --
genes like me logo Genes that share ontologies with ZC3H14: view

No data available for Pathways by source for ZC3H14 Gene

Transcripts for ZC3H14 Gene

Unigene Clusters for ZC3H14 Gene

Zinc finger CCCH-type containing 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - -
SP5:
SP6: - - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11: - - - -
SP12: - - - -
SP13: -
SP14:
SP15: - - -
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21: -

ExUns: 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: - - - - - - - -
SP6: - -
SP7:
SP8:
SP9: - - - - - - - -
SP10: - - - - - -
SP11:
SP12:
SP13:
SP14: - - -
SP15: -
SP16: -
SP17: -
SP18:
SP19:
SP20:
SP21:

Relevant External Links for ZC3H14 Gene

GeneLoc Exon Structure for
ZC3H14
ECgene alternative splicing isoforms for
ZC3H14

Expression for ZC3H14 Gene

mRNA expression in normal human tissues for ZC3H14 Gene

mRNA differential expression in normal tissues according to GTEx for ZC3H14 Gene

This gene is overexpressed in Testis (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3H14 Gene

SOURCE GeneReport for Unigene cluster for ZC3H14 Gene Hs.686171

genes like me logo Genes that share expressions with ZC3H14: view

Orthologs for ZC3H14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZC3H14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H14 36
  • 99.82 (n)
  • 99.86 (a)
ZC3H14 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZC3H14 36
  • 88.92 (n)
  • 89.44 (a)
ZC3H14 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H14 36
  • 93.88 (n)
  • 94.79 (a)
ZC3H14 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc3h14 36
  • 90.61 (n)
  • 89.93 (a)
Zc3h14 16
Zc3h14 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZC3H14 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zc3h14 36
  • 90.61 (n)
  • 89.25 (a)
chicken
(Gallus gallus)
Aves ZC3H14 36
  • 72.23 (n)
  • 71.72 (a)
ZC3H14 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC3H14 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23969 36
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h14 36
  • 59.29 (n)
  • 56.14 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.13570 36
zc3h14 36
  • 57.08 (n)
  • 51.62 (a)
zc3h14 37
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nab2 37
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sut-2 37
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAB2 39
Species with no ortholog for ZC3H14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZC3H14 Gene

ENSEMBL:
Gene Tree for ZC3H14 (if available)
TreeFam:
Gene Tree for ZC3H14 (if available)

Paralogs for ZC3H14 Gene

Pseudogenes.org Pseudogenes for ZC3H14 Gene

genes like me logo Genes that share paralogs with ZC3H14: view

No data available for Paralogs for ZC3H14 Gene

Variants for ZC3H14 Gene

Sequence variations from dbSNP and Humsavar for ZC3H14 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1080569 -- 88,589,206(-) CTTCA(A/T)TGAAA intron-variant
rs1114103 -- 88,589,227(-) CCAAT(A/T)GCAGC intron-variant
rs1344746 -- 88,598,543(-) ACTCT(C/T)CAGAG intron-variant
rs1469602 -- 88,575,836(-) GTCTA(A/C)AAGAG intron-variant
rs1541890 -- 88,580,120(-) CCTCC(C/T)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H14 Gene

Variant ID Type Subtype PubMed ID
nsv456391 CNV Gain 19166990
nsv902181 CNV Gain 21882294
esv2748994 CNV Deletion 23290073
esv2748995 CNV Deletion 23290073
esv2748997 CNV Deletion 23290073
nsv820243 CNV Gain 19587683

Relevant External Links for ZC3H14 Gene

HapMap Linkage Disequilibrium report
ZC3H14
Human Gene Mutation Database (HGMD)
ZC3H14

Disorders for ZC3H14 Gene

genes like me logo Genes that share disorders with ZC3H14: view

No data available for UniProtKB/Swiss-Prot for ZC3H14 Gene

Publications for ZC3H14 Gene

  1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 2 3 4
  2. Recognition of polyadenosine RNA by zinc finger proteins. (PMID: 17630287) Kelly S.M. … Berland K.M. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans. (PMID: 19273536) Guthrie C.R. … Kraemer B.C. (Hum. Mol. Genet. 2009) 3 4
  5. Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein. (PMID: 19303045) Leung S.W. … Corbett A.H. (Gene 2009) 3 4

Products for ZC3H14 Gene

Sources for ZC3H14 Gene

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