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Aliases for ZC3H13 Gene

Aliases for ZC3H13 Gene

  • Zinc Finger CCCH-Type Containing 13 2 3 5
  • KIAA0853 2 3 4

External Ids for ZC3H13 Gene

Previous HGNC Symbols for ZC3H13 Gene

  • KIAA0853

Previous GeneCards Identifiers for ZC3H13 Gene

  • GC13M045426
  • GC13M046528
  • GC13M027333

Summaries for ZC3H13 Gene

GeneCards Summary for ZC3H13 Gene

ZC3H13 (Zinc Finger CCCH-Type Containing 13) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ZC3H13 Gene

  • Acts as component of the WTAP complex that is involved in RNA processing and cell cycle (PubMed:24100041).

Gene Wiki entry for ZC3H13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H13 Gene

Genomics for ZC3H13 Gene

Regulatory Elements for ZC3H13 Gene

Promoters for ZC3H13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZC3H13 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC3H13 Gene

Chromosome:
13
Start:
45,954,465 bp from pter
End:
46,052,761 bp from pter
Size:
98,297 bases
Orientation:
Minus strand

Genomic View for ZC3H13 Gene

Genes around ZC3H13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H13 Gene

Proteins for ZC3H13 Gene

  • Protein details for ZC3H13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T200-ZC3HD_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 13
    Protein Accession:
    Q5T200
    Secondary Accessions:
    • A2A323
    • O94936
    • Q5T1Z9
    • Q7Z7J3
    • Q8NDT6
    • Q9H0L6

    Protein attributes for ZC3H13 Gene

    Size:
    1668 amino acids
    Molecular mass:
    196635 Da
    Quaternary structure:
    • Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).

    Alternative splice isoforms for ZC3H13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H13 Gene

Proteomics data for ZC3H13 Gene at MOPED

Post-translational modifications for ZC3H13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H13 Gene

No data available for DME Specific Peptides for ZC3H13 Gene

Domains & Families for ZC3H13 Gene

Gene Families for ZC3H13 Gene

Protein Domains for ZC3H13 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5T200

UniProtKB/Swiss-Prot:

ZC3HD_HUMAN :
  • Contains 1 C3H1-type zinc finger.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with ZC3H13: view

Function for ZC3H13 Gene

Molecular function for ZC3H13 Gene

UniProtKB/Swiss-Prot Function:
Acts as component of the WTAP complex that is involved in RNA processing and cell cycle (PubMed:24100041).

Gene Ontology (GO) - Molecular Function for ZC3H13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with ZC3H13: view
genes like me logo Genes that share phenotypes with ZC3H13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZC3H13

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H13 Gene

Localization for ZC3H13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H13 Gene

Nucleus speckle. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H13 Gene COMPARTMENTS Subcellular localization image for ZC3H13 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZC3H13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 24100041
genes like me logo Genes that share ontologies with ZC3H13: view

Pathways & Interactions for ZC3H13 Gene

SuperPathways for ZC3H13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZC3H13 Gene

Drugs & Compounds for ZC3H13 Gene

No Compound Related Data Available

Transcripts for ZC3H13 Gene

Unigene Clusters for ZC3H13 Gene

Zinc finger CCCH-type containing 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ZC3H13 Gene

GeneLoc Exon Structure for
ZC3H13
ECgene alternative splicing isoforms for
ZC3H13

Expression for ZC3H13 Gene

mRNA expression in normal human tissues for ZC3H13 Gene

Protein differential expression in normal tissues from HIPED for ZC3H13 Gene

This gene is overexpressed in Liver (20.8) and Brain (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3H13 Gene



SOURCE GeneReport for Unigene cluster for ZC3H13 Gene Hs.136102

genes like me logo Genes that share expression patterns with ZC3H13: view

Protein tissue co-expression partners for ZC3H13 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H13 Gene

Orthologs for ZC3H13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZC3H13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZC3H13 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H13 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZC3H13 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc3h13 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H13 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZC3H13 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H13 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC3H13 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6022 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4590 35
zebrafish
(Danio rerio)
Actinopterygii zgc66359 35
zc3h13 36
  • 44 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.5417 35
Species with no ortholog for ZC3H13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H13 Gene

ENSEMBL:
Gene Tree for ZC3H13 (if available)
TreeFam:
Gene Tree for ZC3H13 (if available)

Paralogs for ZC3H13 Gene

No data available for Paralogs for ZC3H13 Gene

Variants for ZC3H13 Gene

Sequence variations from dbSNP and Humsavar for ZC3H13 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs9534264 - 45,967,538(+) TTTGT(A/T)TCTTC reference, missense
rs962694 -- 46,044,891(+) TTTTA(C/T)ACTAG intron-variant
rs963359 -- 46,012,590(+) CTGAG(A/T)GGGTA intron-variant
rs718530 -- 45,989,518(-) TAGCC(A/G)TGAAT intron-variant
rs1326401 -- 45,997,467(+) TACAC(A/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H13 Gene

Variant ID Type Subtype PubMed ID
dgv250e201 CNV Deletion 23290073
nsv832597 CNV Loss 17160897
nsv900034 CNV Gain 21882294
dgv1579n71 CNV Gain 21882294
nsv832598 CNV Gain 17160897
dgv1580n71 CNV Gain 21882294
dgv1581n71 CNV Loss 21882294
esv2747355 CNV Deletion 23290073
esv2507198 CNV Deletion 19546169
esv2673081 CNV Deletion 23128226
nsv455876 CNV Gain 19166990
esv2666736 CNV Deletion 23128226

Variation tolerance for ZC3H13 Gene

Residual Variation Intolerance Score: 3.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H13 Gene

HapMap Linkage Disequilibrium report
ZC3H13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H13 Gene

Disorders for ZC3H13 Gene

Relevant External Links for ZC3H13

Human Genome Epidemiology (HuGE) Navigator
ZC3H13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H13

No disorders were found for ZC3H13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H13 Gene

Publications for ZC3H13 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for ZC3H13 Gene

Sources for ZC3H13 Gene

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