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Aliases & Descriptions for ZC3H12D
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| C6orf95 2, 5 | | EC 3.1.-.- 3 | | FLJ46041 2 | | MCPIP4 1, 2, 3 | | TFL 2 | | dJ281H8.1 1, 2 | | p34 2, 3, 5 |
| | | Descriptions |
|---|
| MCP induced protein 4 2 | | MCP-induced protein 4 2, 3 | | Probable ribonuclease ZC3H12D 2 | | Zinc finger CCCH domain-containing protein 12D 2, 3 | | chromosome 6 open reading frame 95 1 | | tumor suppressor TFL 2 | | zinc finger CCCH-type containing 12D 2 |
|
| | Search outside databases for aliases for ZC3H12D gene |
Summaries for ZC3H12D(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZC12D_HUMAN, A2A288Function: May function as RNase and regulate the levels of target RNA species (Potential). Putative tumor suppressor |
Genomic Location for ZC3H12D
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ZC3H12D gene 
Entrez Gene cytogenetic band: 6q25.1 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q25.1ZC3H12D Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M149811:
(about GC identifiers)
Start:
|
149,812,571 bp from pter |
End:
|
149,847,890 bp from pter |
Size:
|
35,320 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_025741.14
| Proteins for ZC3H12D
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZC12D_HUMAN, A2A288 (See
protein sequence)Recommended Name: Probable ribonuclease ZC3H12D Size: 527 amino acids; 58098 Da
Cofactor: Magnesium (Potential)
Sequence caution: Sequence=CAM28211.1; Type=Erroneous gene model prediction;
Secondary accessions: A1L178 B2RXF4 Q6ZRW2Alternative splicing: 3 isoforms: A2A288-1 A2A288-2 A2A288-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_997243.1
ENSEMBL proteins: ENSP00000386616 ENSP00000374592 ENSP00000387062
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for ZC3H12D: Assays for ZC3H12D: | Protein
Domains/ Families for ZC3H12D(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: A2A288 UniProtKB/Swiss-Prot: ZC12D_HUMAN, A2A288Similarity: Belongs to the ZC3H12 familySimilarity: Contains 1 C3H1-type zinc finger | Gene Function for ZC3H12D
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                  Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Applied Biosystems Silencer® siRNAs for ZC3H12D
Sigma-Aldrich siRNA for ZC3H12D  Sigma-Aldrich shRNA for ZC3H12D  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_207360                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_207360                                  untagged cDNA clone in CMV expression vector: NM_207360 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_207360
UniProtKB/Swiss-Prot: ZC12D_HUMAN, A2A288Function: May function as RNase and regulate the levels of target RNA species (Potential). Putative tumor suppressorInduction: By prolonged exposure to lipopolysaccharide (LPS) in acute monocytic leukemia cell line THP-1 cellsEnzyme Number (IUBMB): EC 3.1.-.- 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- | About this table | Pathways & Interactions for ZC3H12D
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for ZC3H12D (ENSP000003745923) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for ZC3H12D(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ZC3H12D
|
Transcripts for ZC3H12D(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                  Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Sigma-Aldrich siRNA for ZC3H12D  Sigma-Aldrich shRNA for ZC3H12D  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_207360 REFSEQ mRNAs for ZC3H12D gene: NM_207360.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_207360               OriGene GFP tagged cDNA clone in CMV expression vector: NM_207360                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_207360                                  untagged cDNA clone in CMV expression vector: NM_207360  Additional cDNA sequence: AB458221.1 AB458222.1 AK090441.1 AK127932.1 BC127762.1 BC157832.1 4 DOTS entries: DT.40223841 DT.95086605 DT.430132 DT.100666862 24/154 AceView cDNA sequences (see all 154
):BC020986 BM757769 BE670173 BM759666 AF357880 BQ719311 AK092069 AI915665 CB160587 AA132257 CN478570 AA346646 NM_139126 BC016984 CA441139 BU076634 AA053882 BE887609 BQ019220 AI720056 CB160330 BQ185821 BM562747 BC064134
highest scoring ESTs for ZC3H12D:BM152774 BF975976 AK127932 AW504645 BU430916 CN285548 AA714003 AA837405 AI697060 AK090441 Unigene Cluster for ZC3H12D: Zinc finger CCCH-type containing 12D Hs.632618 [show with all ESTs]Unigene Representative Sequence: AK090441
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000409806
ENST00000389942
ENST00000409948
|
Expression for ZC3H12D
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZC3H12D expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H12D
1 / 2 / 3 2 probe-sets matching ZC3H12D gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTTCAAAAAT
SOURCE GeneReport for Unigene cluster: Hs.632618
|
Orthologs for ZC3H12D
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZC3H12D gene from 5 species
About this table Species with no ortholog for ZC3H12D
ENSEMBL Gene Tree for ZC3H12D | Paralogs for ZC3H12D(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ZC3H12D gene
- ZC3H12C2 ZC3H12B2 ZC3H12A2
|
SNPs/Variants for ZC3H12D(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ZC3H12D (up to first 250kb)
|
Disorders & Mutations for ZC3H12D
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611106
UniProtKB/Swiss-Prot: ZC12D_HUMAN, A2A288
A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed |
Medical News for ZC3H12D(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ZC3H12D (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for ZC3H12D gene:- A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PubMed id 18178554)2, 3, 4 Liang J....Fu M. (2008)
- Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1. (PubMed id 17210687)3, 4 Wang M....You M. (2007)
- Deregulation of a possible tumour suppressor gene, ZC3H12D, by translocation of IGK@ in transformed follicular lymphoma with t(2;6)(p12;q25). (PubMed id 17854321)3, 4 Minagawa K.... Matsui T. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for ZC3H12D
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZC3H12D
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZC3H12D
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZC3H12D(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ZC3H12D(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ZC3H12D:

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