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Aliases for ZC3H12D Gene

Aliases for ZC3H12D Gene

  • Zinc Finger CCCH-Type Containing 12D 2 3
  • C6orf95 3 4 6
  • P34 3 4 6
  • Zinc Finger CCCH Domain-Containing Protein 12D 3 4
  • Transformed Follicular Lymphoma 3 4
  • MCPIP4 3 4
  • TFL 3 4
  • Chromosome 6 Open Reading Frame 95 2
  • Probable Ribonuclease ZC3H12D 3
  • MCP Induced Protein 4 2
  • MCP-Induced Protein 4 4
  • Tumor Suppressor TFL 3
  • EC 3.1.-.- 4
  • DJ281H8.1 3

External Ids for ZC3H12D Gene

Previous HGNC Symbols for ZC3H12D Gene

  • C6orf95

Previous GeneCards Identifiers for ZC3H12D Gene

  • GC06M149811
  • GC06M147335

Summaries for ZC3H12D Gene

GeneCards Summary for ZC3H12D Gene

ZC3H12D (Zinc Finger CCCH-Type Containing 12D) is a Protein Coding gene. Diseases associated with ZC3H12D include patellofemoral pain syndrome and decubitus ulcer. GO annotations related to this gene include endonuclease activity. An important paralog of this gene is N4BP1.

UniProtKB/Swiss-Prot for ZC3H12D Gene

  • May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H12D Gene

Genomics for ZC3H12D Gene

Regulatory Elements for ZC3H12D Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZC3H12D Gene

149,446,795 bp from pter
149,485,061 bp from pter
38,267 bases
Minus strand

Genomic View for ZC3H12D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZC3H12D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H12D Gene

Proteins for ZC3H12D Gene

  • Protein details for ZC3H12D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ribonuclease ZC3H12D
    Protein Accession:
    Secondary Accessions:
    • A1L178
    • B2RXF4
    • B7WNU7
    • B9ZZP9
    • B9ZZQ0
    • Q6ZRW2

    Protein attributes for ZC3H12D Gene

    527 amino acids
    Molecular mass:
    58078 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZC3H12D Gene


neXtProt entry for ZC3H12D Gene

Proteomics data for ZC3H12D Gene at MOPED

Post-translational modifications for ZC3H12D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H12D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC3H12D Gene

Domains for ZC3H12D Gene

Gene Families for ZC3H12D Gene

  • ZC3H :Zinc fingers, CCCH-type domain containing

Protein Domains for ZC3H12D Gene


Suggested Antigen Peptide Sequences for ZC3H12D Gene

Graphical View of Domain Structure for InterPro Entry



  • A2A288
  • Belongs to the ZC3H12 family.
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with ZC3H12D: view

Function for ZC3H12D Gene

Molecular function for ZC3H12D Gene

UniProtKB/Swiss-Prot Function: May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation.
UniProtKB/Swiss-Prot Induction: By prolonged exposure to bacterial lipopolysaccharides (LPS) in acute monocytic leukemia cell line THP-1 cells.

Enzyme Numbers (IUBMB) for ZC3H12D Gene

Gene Ontology (GO) - Molecular Function for ZC3H12D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H12D: view

Phenotypes for ZC3H12D Gene

GenomeRNAi human phenotypes for ZC3H12D:
genes like me logo Genes that share phenotypes with ZC3H12D: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZC3H12D Gene

Localization for ZC3H12D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H12D Gene

Isoform 1: Cytoplasm. Note=Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for ZC3H12D Gene COMPARTMENTS Subcellular localization image for ZC3H12D gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZC3H12D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 24415781
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 19531561
genes like me logo Genes that share ontologies with ZC3H12D: view

Pathways for ZC3H12D Gene

SuperPathways for ZC3H12D Gene

No Data Available

Interacting Proteins for ZC3H12D Gene

Gene Ontology (GO) - Biological Process for ZC3H12D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth IDA 19531561
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA 19531561
genes like me logo Genes that share ontologies with ZC3H12D: view

No data available for Pathways by source for ZC3H12D Gene

Transcripts for ZC3H12D Gene

mRNA/cDNA for ZC3H12D Gene

Unigene Clusters for ZC3H12D Gene

Zinc finger CCCH-type containing 12D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC3H12D

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZC3H12D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12D Gene

No ASD Table

Relevant External Links for ZC3H12D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H12D Gene

mRNA expression in normal human tissues for ZC3H12D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZC3H12D Gene

This gene is overexpressed in Spleen (6.5), Small Intestine - Terminal Ileum (4.7), and Whole Blood (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZC3H12D Gene

SOURCE GeneReport for Unigene cluster for ZC3H12D Gene Hs.632618

mRNA Expression by UniProt/SwissProt for ZC3H12D Gene

Tissue specificity: Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.
genes like me logo Genes that share expressions with ZC3H12D: view

In Situ Assay Products

Orthologs for ZC3H12D Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H12D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZC3H12D 35
  • 98.73 (n)
  • 98.1 (a)
ZC3H12D 36
  • 96 (a)
(Bos Taurus)
Mammalia ZC3H12D 35
  • 79.65 (n)
  • 73.97 (a)
ZC3H12D 36
  • 71 (a)
(Canis familiaris)
Mammalia ZC3H12D 35
  • 79.29 (n)
  • 75.48 (a)
ZC3H12D 36
  • 61 (a)
(Mus musculus)
Mammalia Zc3h12d 35
  • 75.05 (n)
  • 68.03 (a)
Zc3h12d 16
Zc3h12d 36
  • 65 (a)
(Monodelphis domestica)
Mammalia ZC3H12D 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia ZC3H12D 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Zc3h12d 35
  • 73.58 (n)
  • 67.18 (a)
(Anolis carolinensis)
Reptilia ZC3H12D 36
  • 63 (a)
Species with no ortholog for ZC3H12D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZC3H12D Gene

Gene Tree for ZC3H12D (if available)
Gene Tree for ZC3H12D (if available)

Paralogs for ZC3H12D Gene

Paralogs for ZC3H12D Gene

Selected SIMAP similar genes for ZC3H12D Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZC3H12D: view

Variants for ZC3H12D Gene

Sequence variations from dbSNP and Humsavar for ZC3H12D Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs112225 -- 149,464,993(-) CAGCA(A/G)TGTGA intron-variant
rs140859 -- 149,459,601(-) TTAGT(-/TAGT)CATCC intron-variant
rs237005 -- 149,449,043(-) TTCTG(A/G)TTACC utr-variant-3-prime
rs237006 -- 149,447,315(-) TGAGA(C/T)TGTGC downstream-variant-500B
rs237007 -- 149,447,190(-) GTGTT(G/T)TTCCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZC3H12D Gene

Variant ID Type Subtype PubMed ID
nsv470866 CNV Gain 18288195
nsv5533 CNV Loss 18451855
nsv464076 CNV Gain 19166990
esv2732859 CNV Deletion 23290073
esv2670181 CNV Deletion 23128226

Relevant External Links for ZC3H12D Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H12D Gene

Disorders for ZC3H12D Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for ZC3H12D Gene including...

Search for ZC3H12D Gene in MalaCards »


  • Note=A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed.

(3) University of Copenhagen DISEASES for ZC3H12D Gene

genes like me logo Genes that share disorders with ZC3H12D: view

Publications for ZC3H12D Gene

  1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PMID: 18178554) Liang J. … Fu M. (J. Biol. Chem. 2008) 2 3 4
  2. Inhibition of G(1) to S phase progression by a novel zinc finger protein P58(TFL) at P-bodies. (PMID: 19531561) Minagawa K. … Matsui T. (Mol. Cancer Res. 2009) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZC3H12D Gene

Sources for ZC3H12D Gene

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