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Aliases for ZC3H12C Gene

Aliases for ZC3H12C Gene

  • Zinc Finger CCCH-Type Containing 12C 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 12C 3 4
  • MCP-Induced Protein 3 3 4
  • MCPIP3 3 4
  • Probable Ribonuclease ZC3H12C 3
  • MCP Induced Protein 3 2
  • EC 3.1.-.- 4
  • KIAA1726 4

External Ids for ZC3H12C Gene

Previous GeneCards Identifiers for ZC3H12C Gene

  • GC11P109512
  • GC11P109964
  • GC11P105888

Summaries for ZC3H12C Gene

GeneCards Summary for ZC3H12C Gene

ZC3H12C (Zinc Finger CCCH-Type Containing 12C) is a Protein Coding gene. GO annotations related to this gene include endonuclease activity. An important paralog of this gene is ZC3H12B.

UniProtKB/Swiss-Prot for ZC3H12C Gene

  • May function as RNase and regulate the levels of target RNA species.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H12C Gene

Genomics for ZC3H12C Gene

Regulatory Elements for ZC3H12C Gene

Enhancers for ZC3H12C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F110129 1.8 VISTA FANTOM5 Ensembl ENCODE 26.6 +43.3 43275 3.6 ATF1 CEBPG HIC1 POLR2A PATZ1 SCRT2 PRDM10 ZNF600 CREM MAFK ZC3H12C RDX GC11P110167
GH11F110086 1.4 FANTOM5 Ensembl ENCODE 28.2 -0.7 -659 2.5 TBP BMI1 EBF1 POLR2A HNF4G FOS CHD2 MTA2 BHLHE40 TRIM22 ZC3H12C FDX1 LOC390250
GH11F109999 1.5 FANTOM5 Ensembl ENCODE 26 -88.0 -88010 2.0 PKNOX1 ATF1 TBL1XR1 BMI1 ELK1 CBX5 ETV6 FOS CREM CBFB ZC3H12C FDX1 ENSG00000270423 LOC390250
GH11F110091 1.4 FANTOM5 ENCODE 24.6 +5.3 5330 4.3 HDGF WRNIP1 SIN3A YBX1 FEZF1 GLI4 DMAP1 ZNF48 ZNF2 YY1 ZC3H12C FDX1 RDX GC11P110167
GH11F110026 1.5 FANTOM5 Ensembl ENCODE 22.3 -61.4 -61365 1.7 HDGF TBP TBL1XR1 BMI1 RFX5 YY1 CBX5 ZNF207 ETV6 CREM ZC3H12C LOC390250 ENSG00000270423
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC3H12C on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC3H12C Gene

Chromosome:
11
Start:
110,088,412 bp from pter
End:
110,171,841 bp from pter
Size:
83,430 bases
Orientation:
Plus strand

Genomic View for ZC3H12C Gene

Genes around ZC3H12C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H12C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H12C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H12C Gene

Proteins for ZC3H12C Gene

  • Protein details for ZC3H12C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0D7-ZC12C_HUMAN
    Recommended name:
    Probable ribonuclease ZC3H12C
    Protein Accession:
    Q9C0D7
    Secondary Accessions:
    • B4DI65
    • B4DR47

    Protein attributes for ZC3H12C Gene

    Size:
    883 amino acids
    Molecular mass:
    99340 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZC3H12C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H12C Gene

Post-translational modifications for ZC3H12C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H12C Gene

No data available for DME Specific Peptides for ZC3H12C Gene

Domains & Families for ZC3H12C Gene

Gene Families for ZC3H12C Gene

Protein Domains for ZC3H12C Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9C0D7

UniProtKB/Swiss-Prot:

ZC12C_HUMAN :
  • Belongs to the ZC3H12 family.
  • Contains 1 C3H1-type zinc finger.
Family:
  • Belongs to the ZC3H12 family.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with ZC3H12C: view

Function for ZC3H12C Gene

Molecular function for ZC3H12C Gene

UniProtKB/Swiss-Prot Function:
May function as RNase and regulate the levels of target RNA species.
UniProtKB/Swiss-Prot Induction:
By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells.

Enzyme Numbers (IUBMB) for ZC3H12C Gene

Gene Ontology (GO) - Molecular Function for ZC3H12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H12C: view

Phenotypes for ZC3H12C Gene

genes like me logo Genes that share phenotypes with ZC3H12C: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H12C Gene

Localization for ZC3H12C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H12C gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ZC3H12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with ZC3H12C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZC3H12C Gene

Pathways & Interactions for ZC3H12C Gene

SuperPathways for ZC3H12C Gene

No Data Available

Interacting Proteins for ZC3H12C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278590%0d%0a9606.ENSP00000256458%0d%0a
Selected Interacting proteins: ENSP00000278590 Q9C0D7-ZC12C_HUMAN for ZC3H12C Gene via STRING IID

Gene Ontology (GO) - Biological Process for ZC3H12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ZC3H12C: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H12C Gene

Transcripts for ZC3H12C Gene

Unigene Clusters for ZC3H12C Gene

Zinc finger CCCH-type containing 12C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12C Gene

No ASD Table

Relevant External Links for ZC3H12C Gene

GeneLoc Exon Structure for
ZC3H12C
ECgene alternative splicing isoforms for
ZC3H12C

Expression for ZC3H12C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZC3H12C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H12C Gene

This gene is overexpressed in Heart (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZC3H12C Gene



Protein tissue co-expression partners for ZC3H12C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC3H12C Gene:

ZC3H12C

SOURCE GeneReport for Unigene cluster for ZC3H12C Gene:

Hs.376289
genes like me logo Genes that share expression patterns with ZC3H12C: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H12C Gene

Orthologs for ZC3H12C Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H12C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H12C 34 35
  • 99.32 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC3H12C 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3h12c 34
  • 89.66 (n)
mouse
(Mus musculus)
Mammalia Zc3h12c 34 16 35
  • 89.04 (n)
cow
(Bos Taurus)
Mammalia ZC3H12C 34 35
  • 88.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H12C 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H12C 34 35
  • 84.7 (n)
chicken
(Gallus gallus)
Aves ZC3H12C 34 35
  • 81.02 (n)
lizard
(Anolis carolinensis)
Reptilia ZC3H12C 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h12c 34
  • 71.42 (n)
Species where no ortholog for ZC3H12C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZC3H12C Gene

ENSEMBL:
Gene Tree for ZC3H12C (if available)
TreeFam:
Gene Tree for ZC3H12C (if available)

Paralogs for ZC3H12C Gene

Paralogs for ZC3H12C Gene

(3) SIMAP similar genes for ZC3H12C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZC3H12C: view

Variants for ZC3H12C Gene

Sequence variations from dbSNP and Humsavar for ZC3H12C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1026607 -- 110,164,576(-) ACTTG(C/T)GTCCT reference, synonymous-codon
rs1026608 -- 110,164,537(-) GCACC(C/T)CGTTT reference, synonymous-codon
rs10594885 -- 110,111,977(+) CACAC(-/AT)GTACA intron-variant
rs10635583 -- 110,139,870(+) TTTCT(-/TT)TTTTT intron-variant
rs10644570 -- 110,110,711(+) TGTCA(-/CTT)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H12C Gene

Variant ID Type Subtype PubMed ID
nsv958607 CNV deletion 24416366
nsv951068 CNV duplication 24416366
nsv832265 CNV gain 17160897
nsv483 CNV insertion 18451855
nsv39222 CNV deletion 16902084
nsv1159937 CNV deletion 26073780
nsv1148035 CNV deletion 26484159
nsv1122665 CNV deletion 24896259
nsv1119911 CNV deletion 24896259
nsv1070488 CNV deletion 25765185
nsv1070487 CNV deletion 25765185
esv999177 CNV deletion 20482838
esv997753 CNV deletion 20482838
esv5986 CNV loss 19470904
esv3548333 CNV deletion 23714750
esv2745062 CNV deletion 23290073
esv2745061 CNV deletion 23290073
esv2745060 CNV deletion 23290073
esv2745059 CNV deletion 23290073
esv2745058 CNV deletion 23290073
esv2677867 CNV deletion 23128226
esv2548900 CNV deletion 19546169
esv2277863 CNV deletion 18987734
esv1940879 CNV deletion 18987734

Variation tolerance for ZC3H12C Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H12C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H12C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H12C Gene

Disorders for ZC3H12C Gene

Relevant External Links for ZC3H12C

Genetic Association Database (GAD)
ZC3H12C
Human Genome Epidemiology (HuGE) Navigator
ZC3H12C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H12C

No disorders were found for ZC3H12C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H12C Gene

Publications for ZC3H12C Gene

  1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PMID: 18178554) Liang J. … Fu M. (J. Biol. Chem. 2008) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ZC3H12C Gene

Sources for ZC3H12C Gene

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