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Aliases for ZC3H12C Gene

Aliases for ZC3H12C Gene

  • Zinc Finger CCCH-Type Containing 12C 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 12C 3 4
  • MCP Induced Protein 3 2 3
  • MCP-Induced Protein 3 3 4
  • MCPIP3 3 4
  • EC 3.1.-.- 4
  • KIAA1726 4

External Ids for ZC3H12C Gene

Previous GeneCards Identifiers for ZC3H12C Gene

  • GC11P109512
  • GC11P109964
  • GC11P105888

Summaries for ZC3H12C Gene

GeneCards Summary for ZC3H12C Gene

ZC3H12C (Zinc Finger CCCH-Type Containing 12C) is a Protein Coding gene. GO annotations related to this gene include endonuclease activity. An important paralog of this gene is N4BP1.

UniProtKB/Swiss-Prot for ZC3H12C Gene

  • May function as RNase and regulate the levels of target RNA species.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H12C Gene

Genomics for ZC3H12C Gene

Regulatory Elements for ZC3H12C Gene

Enhancers for ZC3H12C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZC3H12C on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC3H12C Gene

110,088,412 bp from pter
110,171,841 bp from pter
83,430 bases
Plus strand

Genomic View for ZC3H12C Gene

Genes around ZC3H12C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H12C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H12C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H12C Gene

Proteins for ZC3H12C Gene

  • Protein details for ZC3H12C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ribonuclease ZC3H12C
    Protein Accession:
    Secondary Accessions:
    • B4DI65
    • B4DR47

    Protein attributes for ZC3H12C Gene

    883 amino acids
    Molecular mass:
    99340 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZC3H12C Gene


neXtProt entry for ZC3H12C Gene

Proteomics data for ZC3H12C Gene at MOPED

Post-translational modifications for ZC3H12C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H12C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZC3H12C Gene

Domains & Families for ZC3H12C Gene

Gene Families for ZC3H12C Gene

Protein Domains for ZC3H12C Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZC3H12 family.
  • Contains 1 C3H1-type zinc finger.
  • Belongs to the ZC3H12 family.
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with ZC3H12C: view

Function for ZC3H12C Gene

Molecular function for ZC3H12C Gene

UniProtKB/Swiss-Prot Function:
May function as RNase and regulate the levels of target RNA species.
UniProtKB/Swiss-Prot Induction:
By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells.

Enzyme Numbers (IUBMB) for ZC3H12C Gene

Gene Ontology (GO) - Molecular Function for ZC3H12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
genes like me logo Genes that share ontologies with ZC3H12C: view

Phenotypes for ZC3H12C Gene

genes like me logo Genes that share phenotypes with ZC3H12C: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H12C Gene

Localization for ZC3H12C Gene

Subcellular locations from

Jensen Localization Image for ZC3H12C Gene COMPARTMENTS Subcellular localization image for ZC3H12C gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZC3H12C Gene

Pathways & Interactions for ZC3H12C Gene

SuperPathways for ZC3H12C Gene

No Data Available

Interacting Proteins for ZC3H12C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000278590 Q9C0D7-ZC12C_HUMAN for ZC3H12C Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ZC3H12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZC3H12C: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H12C Gene

Drugs & Compounds for ZC3H12C Gene

No Compound Related Data Available

Transcripts for ZC3H12C Gene

Unigene Clusters for ZC3H12C Gene

Zinc finger CCCH-type containing 12C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12C Gene

No ASD Table

Relevant External Links for ZC3H12C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H12C Gene

mRNA expression in normal human tissues for ZC3H12C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H12C Gene

This gene is overexpressed in Heart (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZC3H12C Gene

SOURCE GeneReport for Unigene cluster for ZC3H12C Gene Hs.376289

genes like me logo Genes that share expression patterns with ZC3H12C: view

Protein tissue co-expression partners for ZC3H12C Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H12C Gene

Orthologs for ZC3H12C Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H12C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZC3H12C 35
  • 88.77 (n)
  • 92.35 (a)
ZC3H12C 36
  • 92 (a)
(Canis familiaris)
Mammalia ZC3H12C 35
  • 84.7 (n)
  • 89.75 (a)
ZC3H12C 36
  • 89 (a)
(Mus musculus)
Mammalia Zc3h12c 35
  • 89.04 (n)
  • 92.06 (a)
Zc3h12c 16
Zc3h12c 36
  • 90 (a)
(Pan troglodytes)
Mammalia ZC3H12C 35
  • 99.32 (n)
  • 99.54 (a)
ZC3H12C 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zc3h12c 35
  • 89.66 (n)
  • 92.47 (a)
(Monodelphis domestica)
Mammalia ZC3H12C 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ZC3H12C 36
  • 85 (a)
(Gallus gallus)
Aves ZC3H12C 35
  • 81.02 (n)
  • 84.17 (a)
ZC3H12C 36
  • 83 (a)
(Anolis carolinensis)
Reptilia ZC3H12C 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h12c 35
  • 71.42 (n)
  • 72.65 (a)
Species with no ortholog for ZC3H12C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZC3H12C Gene

Gene Tree for ZC3H12C (if available)
Gene Tree for ZC3H12C (if available)

Paralogs for ZC3H12C Gene

Paralogs for ZC3H12C Gene

(3) SIMAP similar genes for ZC3H12C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZC3H12C: view

Variants for ZC3H12C Gene

Sequence variations from dbSNP and Humsavar for ZC3H12C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs581464 -- 110,151,657(+) GATGG(G/T)GCATT intron-variant
rs582846 -- 110,143,827(-) TATCT(C/T)TTTAg intron-variant
rs583020 -- 110,155,442(-) GGGGA(A/C)CTAGT intron-variant
rs583763 -- 110,122,002(-) ACAGA(C/T)AGACT intron-variant
rs584008 -- 110,155,201(-) GAAGC(A/G)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H12C Gene

Variant ID Type Subtype PubMed ID
nsv832265 CNV Gain 17160897
esv2548900 CNV Deletion 19546169
esv2277863 CNV Deletion 18987734
esv2745058 CNV Deletion 23290073
esv2677867 CNV Deletion 23128226
esv5986 CNV Loss 19470904
esv997753 CNV Deletion 20482838
nsv483 CNV Insertion 18451855
esv2745059 CNV Deletion 23290073
esv1940879 CNV Deletion 18987734
esv2745060 CNV Deletion 23290073
esv2745061 CNV Deletion 23290073
esv2745062 CNV Deletion 23290073
nsv39222 CNV Loss 16902084
esv999177 CNV Deletion 20482838

Variation tolerance for ZC3H12C Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZC3H12C Gene

Disorders for ZC3H12C Gene

Relevant External Links for ZC3H12C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZC3H12C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H12C Gene

Publications for ZC3H12C Gene

  1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PMID: 18178554) Liang J. … Fu M. (J. Biol. Chem. 2008) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. Genetic Variation in Imprinted Genes is Associated with Risk of Late-Onset Alzheimer's Disease. (PMID: 25391383) Chaudhry M. … Kamboh M.I. (J. Alzheimers Dis. 2014) 3
  5. Zc3h12c inhibits vascular inflammation by repressing NF-I_B activation and pro-inflammatory gene expression in endothelial cells. (PMID: 23360436) Liu L. … Chen Y.E. (Biochem. J. 2013) 3

Products for ZC3H12C Gene

Sources for ZC3H12C Gene