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ZC3H12C Gene

protein-coding GIFtS: 41

GC11P109512

zinc finger CCCH-type containing 12C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.-.- ^³
KIAA1726 ^¹, ², ³
MCPIP3 ^¹, ², ³

Descriptions
MCP induced protein 3 ^²
MCP-induced protein 3 ^², ³
Zinc finger CCCH domain-containing protein 12C ^³
zinc finger CCCH-type containing 12C ^²

External Ids
HGNC: 29362¹
Entrez Gene: 85463²
UniProtKB: Q9C0D7³
Ensembl: ENSG00000149289⁷

Search outside databases for aliases for ZC3H12C gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ZC12C_HUMAN, Q9C0D7

Function: May function as RNase and regulate the levels of target RNA species (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZC3H12C gene

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3

ZC3H12C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P109512: (about GC identifiers)

Start:	109,469,297 bp from pter
End:	109,547,776 bp from pter
Size:	78,480 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZC12C_HUMAN, Q9C0D7 (See protein sequence)

Recommended Name: Probable ribonuclease ZC3H12C

Size: 883 amino acids; 99340 Da

Cofactor: Magnesium (Potential)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_203748.1

ENSEMBL proteins:

ENSP00000278590

Human Recombinant Proteins

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	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ZC3H12C:

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Assays for ZC3H12C:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9C0D7

UniProtKB/Swiss-Prot: ZC12C_HUMAN, Q9C0D7

Similarity: Belongs to the ZC3H12 family

Similarity: Contains 1 C3H1-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H12C)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Applied Biosystems Silencer® siRNAs for ZC3H12C

Sigma-Aldrich siRNA for ZC3H12C

Sigma-Aldrich shRNA for ZC3H12C

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_033390
Myc/DDK tagged cDNA clone in CMV expression vector: NM_033390
untagged cDNA clone in CMV expression vector: NM_033390

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_033390

UniProtKB/Swiss-Prot: ZC12C_HUMAN, Q9C0D7

Function: May function as RNase and regulate the levels of target RNA species (Potential)

Induction: By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1

cells

Enzyme Number (IUBMB): EC 3.1.-.-

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZC3H12C

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H12C)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Sigma-Aldrich siRNA for ZC3H12C

Sigma-Aldrich shRNA for ZC3H12C

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_033390

REFSEQ mRNAs for ZC3H12C gene:

NM_033390.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_033390

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_033390
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_033390
                                 untagged cDNA clone in CMV expression vector: NM_033390

Additional cDNA sequence:

AB051513.1 AK095101.1 AK295437.1 AK299100.1 AL832893.1

4 DOTS entries:

DT.440879 DT.99936753 DT.120720078 DT.99941546

24/52 AceView cDNA sequences (see all 52 ):

CD723560 AI079998 AI400987 CA392682 AB051513 AW613118 BX503186 AL832893

AI473385 AI471614 BX956872 CK429170 AB096241 BQ723735 AI521768 BX505366

BG654599 AA136356 AA131471 AL706019 BI869862 CA392681 AI452795 BG534565

highest scoring ESTs for ZC3H12C:

AA126803 AI142861 AA131471 AA131653 AA136268 AA136356 AB051513 AB096241 AI400987 AI471614

Unigene Cluster for ZC3H12C:

Zinc finger CCCH-type containing 12C

Hs.376289 [show with all ESTs]

Unigene Representative Sequence: NM_033390

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000278590

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ZC3H12C expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H12C

¹ / ² / ³

7 probe-sets matching ZC3H12C gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
59365_at²^{, 3}	U95-B	1	1.00	1.00	0.83	1.75	D59637	0.80	1.00	0.91	1
47845_at²^{, 3}	U95-B	1	1.00	1.00	0.24	0.43	AI142861	1.00	1.00	1.00	1
91763_at²^{, 3}	U95-D	1	1.00	1.00	0.36	0.51	AI400987	0.80	1.00	0.91	1
41979_r_at²^{, 3}	U95-B	1	0.94	1.00	0.76	0.81	AA126803	1.00	1.00	1.00	1
231899_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB051513	0.80	1.00	0.91	1
1559763_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
231899_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZC3H12C for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: ATTAATTCCT

SOURCE GeneReport for Unigene cluster: Hs.376289

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZC3H12C gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZC3H12C¹	--	zinc finger CCCH-type containing 12C	84.4(n) 90.32(a)	489416 XM_546534.2 XP_546534.2
chimpanzee (Pan troglodytes)	ZC3H12C¹	--	zinc finger CCCH-type containing 12C	99.41(n) 99.77(a)	466775 XM_522175.2 XP_522175.2
cow (Bos taurus)	ZC3H12C¹	--	zinc finger CCCH-type containing 12C	88.77(n) 92.35(a)	512586 XM_590126.3 XP_590126.2
rat (Rattus norvegicus)	Zc3h12c¹	--	zinc finger CCCH type containing 12C	89.65(n) 92.47(a)	315658 XM_236237.4 XP_236237.4
mouse (Mus musculus)	Zc3h12c^{1, 5}	9⁵	zinc finger CCCH type containing 12C^{1, 5}	89.04(n)¹ 92.06(a)¹	244871¹ XM_146893.6¹ XP_146893.6¹ AI642677⁵ AK039211⁵ (see all 11)

About this table Species with no ortholog for ZC3H12C

ENSEMBL Gene Tree for ZC3H12C

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZC3H12C gene

ZC3H12B² ZC3H12D² ZC3H12A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/542 NCBI SNPs in ZC3H12C are shown (see all 542 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 205)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4561177^1,2	A,C,F,H	109467642(+)	`CCCCAA/GTAAGC`	1	--	ng5¹		12		EU EA WA	1258
	rs3825062^1,2	A,C,F,H	109547887(+)	`TAGGGA/TCCTCG`	1	--	ng3¹		8		EU EA WA	838
	rs4754425^1,2	A,C,F,H	109547367(+)	`GAAAAG/ATAAGG`	1	--	ut3¹		4		EU EA WA	408
--	rs3741339^1,2	A,C	109547538(+)	`AAAAAA/TTTTTT`	1	--	ut3¹ trp³		0	--	--	--	--
--	rs9787733^1,2	A,C	109548122(+)	`aaaaaA/Caaaaa`	1	--	ng3¹		0	--	--	--	--
--	rs4356188^1,2	A	109468955(+)	`GAGCCC/GAGCGC`	1	--	ng5¹		0	--	--	--	--
	rs1784671^1,2	H	109545556(+)	`TTCCAA/TATATA`	1	--	ut3¹ ese³		4		EU EA WA	416
	rs607217^1,2	H	109546336(-)	`AAGCCA/CAAACC`	1	--	ut3¹		5		MN EU EA WA	572
	rs3824940^1,2	H	109540531(+)	`CCTAGA/TAGAAA`	1	E/V	mis¹ ese³ trp³		4		EU EA WA	414
	rs12786675^1,2	H	109544043(+)	`CTTAGG/TTGAGA`	1	--	ut3¹ ese³		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for ZC3H12C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for ZC3H12C gene:

A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PubMed id 18178554)^{2, 3, 4} Liang J....Fu M. (2008)
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{2, 3, 4} Nagase T....Ohara O. (2000)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)⁴ Taylor T.D....Sakaki Y. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 85463	HGNC: 29362	AceView: KIAA1726	Ensembl:ENSG00000149289	euGenes: HUgn85463
ECgene: ZC3H12C	H-InvDB: ZC3H12C

(According to HUGE)
About This Section

HUGE: KIAA1726

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZC3H12C
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ZC3H12C:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZC3H12C-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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ZC3H12C Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for ZC3H12C

Summaries
for ZC3H12C

Genomic Location
for ZC3H12C

Proteins
for ZC3H12C

Protein Domains/
Families
for ZC3H12C

Gene Function
for ZC3H12C

Pathways & Interactions
for ZC3H12C

Drugs & Compounds
for ZC3H12C

Transcripts
for ZC3H12C

Expression
for ZC3H12C

Orthologs
for ZC3H12C

Paralogs
for ZC3H12C

SNPs/Variants
for ZC3H12C

Disorders & Mutations
for ZC3H12C

Medical News
for ZC3H12C

Publications
for ZC3H12C

Search for ZC3H12C

Genome Databases showing ZC3H12C

Other Databases showing ZC3H12C

Specialized Databases showing ZC3H12C

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZC3H12C Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor ZC3H12C

Summariesfor ZC3H12C

Genomic Locationfor ZC3H12C

Proteinsfor ZC3H12C

Protein Domains/Familiesfor ZC3H12C

Gene Functionfor ZC3H12C

Pathways & Interactionsfor ZC3H12C

Drugs & Compoundsfor ZC3H12C

Transcriptsfor ZC3H12C

Expression for ZC3H12C

Orthologsfor ZC3H12C

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Disorders & Mutationsfor ZC3H12C

Medical Newsfor ZC3H12C

Publicationsfor ZC3H12C

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Genome Databases showing ZC3H12C

Other Databases showing ZC3H12C

Specialized Databases showing ZC3H12C

Licensable Technologiesfor ZC3H12C

Servicesfor ZC3H12C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZC3H12C

Summaries
for ZC3H12C

Genomic Location
for ZC3H12C

Proteins
for ZC3H12C

Protein Domains/
Families
for ZC3H12C

Gene Function
for ZC3H12C

Pathways & Interactions
for ZC3H12C

Drugs & Compounds
for ZC3H12C

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