Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZC3H12B Gene

Aliases for ZC3H12B Gene

  • Zinc Finger CCCH-Type Containing 12B 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 12B 3 4
  • MCP-Induced Protein 2 3 4
  • CXorf32 3 4
  • MCPIP2 3 4
  • Chromosome X Open Reading Frame 32 2
  • Probable Ribonuclease ZC3H12B 3
  • MCP Induced Protein 2 2
  • EC 3.1.-.- 4

External Ids for ZC3H12B Gene

Previous HGNC Symbols for ZC3H12B Gene

  • CXorf32

Previous GeneCards Identifiers for ZC3H12B Gene

  • GC0XP064492
  • GC0XP064625
  • GC0XP058536
  • GC0XP064708
  • GC0XP065366

Summaries for ZC3H12B Gene

Entrez Gene Summary for ZC3H12B Gene

  • The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. [provided by RefSeq, May 2010]

GeneCards Summary for ZC3H12B Gene

ZC3H12B (Zinc Finger CCCH-Type Containing 12B) is a Protein Coding gene. GO annotations related to this gene include endonuclease activity. An important paralog of this gene is ZC3H12C.

UniProtKB/Swiss-Prot for ZC3H12B Gene

  • May function as RNase and regulate the levels of target RNA species.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H12B Gene

Genomics for ZC3H12B Gene

Regulatory Elements for ZC3H12B Gene

Enhancers for ZC3H12B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF065244 0.3 FANTOM5 1.4 +210.1 210094 0.3 ZC3H12B ZC4H2 CCT4P2 LOC100533843
GH0XF065034 1 FANTOM5 ENCODE 0.8 +0.3 339 2.1 PKNOX1 BMI1 ZNF48 ZNF2 RAD21 GLIS2 CREM ZNF263 ZBTB2 SP5 AMER1 ZC4H2 ZC3H12B LOC100533843
GH0XF065127 0.7 ENCODE 0.1 +93.0 92951 0.8 LAS1L LOC100533843 ZC3H12B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZC3H12B on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H12B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160808 401 2001 BMI1 ZNF48 ZNF2 RAD21 GLIS2 CREM ZNF263 ZBTB2 SP5 ZEB2

Genomic Location for ZC3H12B Gene

Chromosome:
X
Start:
65,034,799 bp from pter
End:
65,507,887 bp from pter
Size:
473,089 bases
Orientation:
Plus strand

Genomic View for ZC3H12B Gene

Genes around ZC3H12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H12B Gene

Proteins for ZC3H12B Gene

  • Protein details for ZC3H12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYM0-ZC12B_HUMAN
    Recommended name:
    Probable ribonuclease ZC3H12B
    Protein Accession:
    Q5HYM0
    Secondary Accessions:
    • B2RTQ3
    • E9PAJ6
    • Q5H9C0

    Protein attributes for ZC3H12B Gene

    Size:
    836 amino acids
    Molecular mass:
    94205 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI40768.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI71781.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI42594.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI42834.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI46044.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZC3H12B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC3H12B Gene

Post-translational modifications for ZC3H12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZC3H12B Gene

Domains & Families for ZC3H12B Gene

Gene Families for ZC3H12B Gene

Protein Domains for ZC3H12B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC3H12B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HYM0

UniProtKB/Swiss-Prot:

ZC12B_HUMAN :
  • Belongs to the ZC3H12 family.
  • Contains 1 C3H1-type zinc finger.
Family:
  • Belongs to the ZC3H12 family.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with ZC3H12B: view

Function for ZC3H12B Gene

Molecular function for ZC3H12B Gene

UniProtKB/Swiss-Prot Function:
May function as RNase and regulate the levels of target RNA species.

Enzyme Numbers (IUBMB) for ZC3H12B Gene

Gene Ontology (GO) - Molecular Function for ZC3H12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H12B: view
genes like me logo Genes that share phenotypes with ZC3H12B: view

Animal Model Products

miRNA for ZC3H12B Gene

miRTarBase miRNAs that target ZC3H12B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H12B Gene

Localization for ZC3H12B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H12B Gene COMPARTMENTS Subcellular localization image for ZC3H12B gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZC3H12B Gene

Pathways & Interactions for ZC3H12B Gene

SuperPathways for ZC3H12B Gene

No Data Available

Interacting Proteins for ZC3H12B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000340839%0d%0a9606.ENSP00000357597%0d%0a
Selected Interacting proteins: ENSP00000340839 for ZC3H12B Gene via STRING

Symbol External ID(s) Details
TSPYL1

Gene Ontology (GO) - Biological Process for ZC3H12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ZC3H12B: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H12B Gene

Transcripts for ZC3H12B Gene

mRNA/cDNA for ZC3H12B Gene

Unigene Clusters for ZC3H12B Gene

Zinc finger CCCH-type containing 12B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12B Gene

No ASD Table

Relevant External Links for ZC3H12B Gene

GeneLoc Exon Structure for
ZC3H12B
ECgene alternative splicing isoforms for
ZC3H12B

Expression for ZC3H12B Gene

mRNA expression in normal human tissues for ZC3H12B Gene

Protein differential expression in normal tissues from HIPED for ZC3H12B Gene

This gene is overexpressed in Urine (46.1), Plasma (9.7), and Bone marrow mesenchymal stem cell (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZC3H12B Gene



NURSA nuclear receptor signaling pathways regulating expression of ZC3H12B Gene:

ZC3H12B

SOURCE GeneReport for Unigene cluster for ZC3H12B Gene:

Hs.21249
genes like me logo Genes that share expression patterns with ZC3H12B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZC3H12B Gene

Orthologs for ZC3H12B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H12B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H12B 34 35
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia ZC3H12B 34 35
  • 92.5 (n)
dog
(Canis familiaris)
Mammalia ZC3H12B 34 35
  • 91.79 (n)
rat
(Rattus norvegicus)
Mammalia Zc3h12b 34
  • 89.65 (n)
mouse
(Mus musculus)
Mammalia Zc3h12b 34 16 35
  • 89.57 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC3H12B 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H12B 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H12B 34 35
  • 75.99 (n)
lizard
(Anolis carolinensis)
Reptilia ZC3H12B 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h12b 34
  • 71.79 (n)
zebrafish
(Danio rerio)
Actinopterygii zc3h12b 35
  • 65 (a)
OneToOne
LOC100002370 34
  • 64.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42360 35
  • 18 (a)
OneToOne
Species where no ortholog for ZC3H12B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H12B Gene

ENSEMBL:
Gene Tree for ZC3H12B (if available)
TreeFam:
Gene Tree for ZC3H12B (if available)

Paralogs for ZC3H12B Gene

Paralogs for ZC3H12B Gene

(4) SIMAP similar genes for ZC3H12B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZC3H12B: view

Variants for ZC3H12B Gene

Sequence variations from dbSNP and Humsavar for ZC3H12B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10037388 -- 65,381,622(+) aggaa(A/G)tagat intron-variant
rs10126240 -- 65,039,679(+) ATTGT(C/T)TAAAA intron-variant
rs10127007 -- 65,116,023(+) tattt(A/C)tttta intron-variant
rs10127369 -- 65,166,609(+) cttga(C/T)gaatc intron-variant
rs10127403 -- 65,302,143(+) cacta(C/T)tcttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H12B Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354

Variation tolerance for ZC3H12B Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.15; 84.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H12B Gene

Human Gene Mutation Database (HGMD)
ZC3H12B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H12B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H12B Gene

Disorders for ZC3H12B Gene

Relevant External Links for ZC3H12B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H12B

No disorders were found for ZC3H12B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H12B Gene

Publications for ZC3H12B Gene

  1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PMID: 18178554) Liang J. … Fu M. (J. Biol. Chem. 2008) 2 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ZC3H12B Gene

Sources for ZC3H12B Gene

Content
Loading form....