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Aliases for ZC3H12B Gene

Aliases for ZC3H12B Gene

  • Zinc Finger CCCH-Type Containing 12B 2 3
  • MCPIP2 3 4 6
  • Zinc Finger CCCH Domain-Containing Protein 12B 3 4
  • MCP-Induced Protein 2 3 4
  • CXorf32 3 4
  • Chromosome X Open Reading Frame 32 2
  • Probable Ribonuclease ZC3H12B 3
  • MCP Induced Protein 2 2
  • EC 3.1.-.- 4

External Ids for ZC3H12B Gene

Previous Symbols for ZC3H12B Gene

  • CXorf32

Summaries for ZC3H12B Gene

Entrez Gene Summary for ZC3H12B Gene

  • The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. [provided by RefSeq, May 2010]

GeneCards Summary for ZC3H12B Gene

ZC3H12B (Zinc Finger CCCH-Type Containing 12B) is a Protein Coding gene. GO annotations related to this gene include endonuclease activity. An important paralog of this gene is N4BP1.

UniProtKB/Swiss-Prot for ZC3H12B Gene

  • May function as RNase and regulate the levels of target RNA species.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H12B Gene

Genomics for ZC3H12B Gene

Genomic Location for ZC3H12B Gene

65,366,638 bp from pter
65,507,887 bp from pter
141,250 bases
Plus strand

Genomic View for ZC3H12B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZC3H12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H12B Gene

Regulatory Elements for ZC3H12B Gene

Proteins for ZC3H12B Gene

  • Protein details for ZC3H12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ribonuclease ZC3H12B
    Protein Accession:
    Secondary Accessions:
    • B2RTQ3
    • E9PAJ6
    • Q5H9C0

    Protein attributes for ZC3H12B Gene

    836 amino acids
    Molecular mass:
    94205 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=AAI40768.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI71781.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI42594.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI42834.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI46044.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZC3H12B Gene


neXtProt entry for ZC3H12B Gene

Proteomics data for ZC3H12B Gene at MOPED

Post-translational modifications for ZC3H12B Gene

No Post-translational modifications

Other Protein References for ZC3H12B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC3H12B Gene

Domains for ZC3H12B Gene

Gene Families for ZC3H12B Gene

  • ZC3H :Zinc fingers, CCCH-type domain containing

Protein Domains for ZC3H12B Gene



  • Belongs to the ZC3H12 family.:
    • Q5HYM0
  • Contains 1 C3H1-type zinc finger.:
    • Q5HYM0
genes like me logo Genes that share domains with ZC3H12B: view

Function for ZC3H12B Gene

Molecular function for ZC3H12B Gene

UniProtKB/Swiss-Prot Function: May function as RNase and regulate the levels of target RNA species.

Enzyme Numbers (IUBMB) for ZC3H12B Gene

Gene Ontology (GO) - Molecular Function for ZC3H12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H12B: view
genes like me logo Genes that share phenotypes with ZC3H12B: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZC3H12B Gene

Localization for ZC3H12B Gene

Subcellular locations from

Jensen Localization Image for ZC3H12B Gene COMPARTMENTS Subcellular localization image for ZC3H12B gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for ZC3H12B Gene

Pathways for ZC3H12B Gene

SuperPathways for ZC3H12B Gene

No Data Available

Interacting Proteins for ZC3H12B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000340839 for ZC3H12B Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ZC3H12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ZC3H12B: view

No data available for Pathways by source for ZC3H12B Gene

Transcripts for ZC3H12B Gene

mRNA/cDNA for ZC3H12B Gene

Unigene Clusters for ZC3H12B Gene

Zinc finger CCCH-type containing 12B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12B Gene

No ASD Table

Relevant External Links for ZC3H12B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H12B Gene

mRNA expression in normal human tissues for ZC3H12B Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZC3H12B Gene

SOURCE GeneReport for Unigene cluster for ZC3H12B Gene Hs.21249

genes like me logo Genes that share expressions with ZC3H12B: view

Orthologs for ZC3H12B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC3H12B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZC3H12B 36
  • 99.76 (n)
  • 99.64 (a)
ZC3H12B 37
  • 100 (a)
(Bos Taurus)
Mammalia ZC3H12B 36
  • 92.5 (n)
  • 92.46 (a)
ZC3H12B 37
  • 92 (a)
(Canis familiaris)
Mammalia ZC3H12B 36
  • 91.79 (n)
  • 92.7 (a)
ZC3H12B 37
  • 93 (a)
(Mus musculus)
Mammalia Zc3h12b 36
  • 89.57 (n)
  • 90.89 (a)
Zc3h12b 16
Zc3h12b 37
  • 91 (a)
(Monodelphis domestica)
Mammalia ZC3H12B 37
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia ZC3H12B 37
  • 65 (a)
(Rattus norvegicus)
Mammalia Zc3h12b 36
  • 89.65 (n)
  • 90.89 (a)
(Gallus gallus)
Aves ZC3H12B 36
  • 75.99 (n)
  • 80.39 (a)
ZC3H12B 37
  • 78 (a)
(Anolis carolinensis)
Reptilia ZC3H12B 37
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zc3h12b 36
  • 71.79 (n)
  • 75.33 (a)
(Danio rerio)
Actinopterygii LOC100002370 36
  • 64.89 (n)
  • 69.39 (a)
zc3h12b 37
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42360 37
  • 18 (a)
Species with no ortholog for ZC3H12B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H12B Gene

Gene Tree for ZC3H12B (if available)
Gene Tree for ZC3H12B (if available)

Paralogs for ZC3H12B Gene

Paralogs for ZC3H12B Gene

Selected SIMAP similar genes for ZC3H12B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZC3H12B: view

Variants for ZC3H12B Gene

Sequence variations from dbSNP and Humsavar for ZC3H12B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2038283 -- 65,503,622(+) tcttt(A/C/T)ttttt utr-variant-3-prime
rs2038284 -- 65,504,929(+) GTTAC(G/T)CACTT utr-variant-3-prime
rs2038285 -- 65,505,458(+) CTATC(C/T)TCTGA utr-variant-3-prime
rs4827440 -- 65,488,402(+) GGGTA(C/G)GGGGG upstream-variant-2KB, intron-variant
rs5902584 -- 65,503,634(+) TTTTT(-/T)GAGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZC3H12B Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354

Relevant External Links for ZC3H12B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for ZC3H12B Gene

No disorders were found for ZC3H12B Gene.

No data available for UniProtKB/Swiss-Prot for ZC3H12B Gene

Publications for ZC3H12B Gene

  1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PMID: 18178554) Liang J. … Fu M. (J. Biol. Chem. 2008) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for ZC3H12B Gene

  • antibodies-online peptides for ZC3H12B
  • antibodies-online antibodies for ZC3H12B
  • antibodies-online kits for ZC3H12B

Sources for ZC3H12B Gene

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