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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZC3H12B Gene

protein-coding   GIFtS: 43
GCID: GC0XP064708

Zinc Finger CCCH-Type Containing 12B

(Previous name: chromosome X open reading frame 32)
(Previous symbol: CXorf32)
  Search for ZC3H12B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger CCCH-Type Containing 12B1 2     Chromosome X Open Reading Frame 321
CXorf321 2 3     MCP Induced Protein 21
Zinc Finger CCCH Domain-Containing Protein 12B2 3     Probable Ribonuclease ZC3H12B2
MCPIP22 3     EC 3.1.-.-3
MCP-Induced Protein 22 3     

External Ids:    HGNC: 174071   Entrez Gene: 3405542   Ensembl: ENSG000001020537   OMIM: 3008895   UniProtKB: Q5HYM03   

Export aliases for ZC3H12B gene to outside databases

Previous GC identifers: GC0XP064492 GC0XP064625 GC0XP058536


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZC3H12B Gene:
The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the
proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought
to function as a ribonuclease. (provided by RefSeq, May 2010)

GeneCards Summary for ZC3H12B Gene: 
ZC3H12B (zinc finger CCCH-type containing 12B) is a protein-coding gene. GO annotations related to this gene include endonuclease activity and nucleic acid binding. An important paralog of this gene is NYNRIN.

UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0
Function: May function as RNase and regulate the levels of target RNA species (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011669.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZC3H12B gene promoter:
         STAT1   GCNF   GCNF-1   FOXO1a   GCNF-2   FOXO1   En-1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC3H12B promoter sequence
   Search SABiosciences Chromatin IP Primers for ZC3H12B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H12B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq12   Ensembl cytogenetic band:  Xq12   HGNC cytogenetic band: Xq12

ZC3H12B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3H12B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP064708:  view genomic region     (about GC identifiers)

Start:
64,708,615 bp from pter      End:
64,727,767 bp from pter
Size:
19,153 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0 (See protein sequence)
Recommended Name: Probable ribonuclease ZC3H12B  
Size: 825 amino acids; 93046 Da
Cofactor: Magnesium (Potential)
Sequence caution: Sequence=CAI42594.1; Type=Erroneous gene model prediction; Sequence=CAI42834.1; Type=Erroneous
gene model prediction;
Secondary accessions: B2RTQ3 Q5H9C0
Alternative splicing: 2 isoforms:  Q5HYM0-1   Q5HYM0-2   

Explore the universe of human proteins at neXtProt for ZC3H12B: NX_Q5HYM0

Explore proteomics data for ZC3H12B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5HYM0

  • ZC3H12B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZC3H12B Protein Expression
    REFSEQ proteins: NP_001010888.3  
    ENSEMBL proteins: 
     ENSP00000340839   ENSP00000408077  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC3H: Zinc fingers, CCCH-type domain containing

    2 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR021869 RNase_Zc3h12

    Graphical View of Domain Structure for InterPro Entry Q5HYM0

    ProtoNet protein and cluster: Q5HYM0

    UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0
    Similarity: Belongs to the ZC3H12 family
    Similarity: Contains 1 C3H1-type zinc finger


    ZC3H12B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZC12B_HUMAN, Q5HYM0
    Function: May function as RNase and regulate the levels of target RNA species (Potential)

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0004519endonuclease activity IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZC3H12B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZC3H12B:
     Decreased TP53 protein express  Decreased viability of wild-ty  Upregulation of NF-kappaB path 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3H12B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZC3H12B (ZC12B)

    Search CenterWatch for drugs/clinical trials and news about ZC3H12B / ZC12B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZC3H12B gene: 
    NM_001010888.3  

    Unigene Cluster for ZC3H12B:

    Zinc finger CCCH-type containing 12B
    Hs.21249  [show with all ESTs]
    Unigene Representative Sequence: NM_001010888
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338957(uc010nko.3) ENST00000423889
    miRNA
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    hsa-miR-323-3p hsa-miR-300 hsa-miR-146a hsa-miR-15a hsa-miR-938 hsa-miR-128 hsa-miR-485-3p hsa-miR-374a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC3H12B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC3H12B

    Additional mRNA sequence: 

    AK091685.1 BC140767.1 BC171781.1 BX647241.1 

    3 DOTS entries:

    DT.40302996  DT.121290870  DT.91840048 

    24/31 AceView cDNA sequences (see all 31):

    Z40081 BX647241 AL538134 F01575 CR595814 AA393649 BX415643 AK091685 
    W25351 F10287 AW007160 BU688430 AI022457 AI139147 BX445086 Z44033 
    BU688472 F12676 F05315 BF218384 BX478773 BX415642 BX452193 H14594 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZC3H12B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTTTTGTT
    ZC3H12B Expression
    About this image


    See ZC3H12B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZC3H12B

    SOURCE GeneReport for Unigene cluster: Hs.21249
        SABiosciences Custom PCR Arrays for ZC3H12B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H12B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZC3H12B gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc3h12b1 , 5 zinc finger CCCH-type containing 12B1, 5 89.57(n)1
    90.89(a)1
      X (42.14 cM)5
    5471761  NM_001034907.21  NP_001030079.21 
     957116785 
    chicken
    (Gallus gallus)
    Aves ZC3H12B1 zinc finger CCCH-type containing 12B 75.75(n)
    80.27(a)
      422175  XM_003641129.1  XP_003641177.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZC3H12B6
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343376.1(758669-765867)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000023701 similar to zinc finger CCCH-type containing 12B 64.68(n)
    68.57(a)
      100002370  XM_001342136.4  XP_001342172.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG108896
    --
    34(a)
    1 → many
    3R(15859603-15861777)
    worm
    (Caenorhabditis elegans)
    Secernentea C30F12.16
    Protein C30F12.1
    28(a)
    1 → many
    I(6954411-6961139)


    ENSEMBL Gene Tree for ZC3H12B (if available)
    TreeFam Gene Tree for ZC3H12B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZC3H12B gene
    NYNRIN2  ZC3H12C2  N4BP12  ZC3H12D2  KHNYN2  ZC3H12A2  
    4 SIMAP similar genes for ZC3H12B using alignment to 2 protein entries:     ZC12B_HUMAN (see all proteins):
    ZC3H12D    ZC3H12A    ZC3H12C    KHNYN

    ZC3H12B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/242 SNPs in ZC3H12B are shown (see all 242)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs601801211,2
    C--64712001(+) TTTTT-/TGTTTT 1 -- int10--------
    rs1809415681,2
    --64714483(+) TGTCTA/GTGTGT 1 -- us2k10--------
    rs1861949671,2
    --64714569(+) TGAATA/GTCGTT 1 -- us2k10--------
    rs1909531741,2
    --64714592(+) ATTACA/GTTTGG 1 -- us2k10--------
    rs1827245351,2
    --64714793(+) CCAACA/GTGGTG 1 -- us2k10--------
    rs1870101281,2
    --64714920(+) GCAGCA/GAGCTG 1 -- us2k10--------
    rs2001556611,2
    --64714975(+) GTCTT-/AAAAAA 1 -- us2k10--------
    rs113085501,2
    C--64714989(+) AAACC-/AAAAAA 1 -- us2k10--------
    rs1917549221,2
    --64715142(+) TCAGGA/TAAGTG 1 -- us2k10--------
    rs1453431981,2
    C--64715180(+) CACCTC/TTCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZC3H12B (64708615 - 64727767 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZC3H12B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1584074OTHER Inversion17803354


    Locus Specific Mutation Databases (LSDB): ZC3H12B
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ZC3H12B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZC3H12B for disorders           About MalaCards
    OMIM gene information: 300889    OMIM disorders: --


    ZC3H12B for disorders           About GeneDecksing


    Export disorders for ZC3H12B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZC3H12B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZC3H12B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PubMed id 18178554)1, 2, 3 Liang J....Fu M. (2008)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340554 HGNC: 17407 AceView: CXorf32 Ensembl:ENSG00000102053 euGenes: HUgn340554
    ECgene: ZC3H12B H-InvDB: ZC3H12B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZC3H12B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZC3H12B gene:
    Search GeneIP for patents involving ZC3H12B

    GeneCards and IP:
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