ZC3H12B Gene
protein-coding GIFtS: 43
GCID: GC0XP064708
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zinc finger CCCH-type containing 12B(Previous name: chromosome X open reading frame 32 )
(Previous symbol: CXorf32)
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Aliases
for ZC3H12B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger CCCH-Type Containing 12B1 2 | | MCP-Induced Protein 22 3 | | CXorf321 2 3 | | Chromosome X Open Reading Frame 321 | | MCPIP21 2 3 | | Probable Ribonuclease ZC3H12B2 | | Zinc Finger CCCH Domain-Containing Protein 12B2 3 | | EC 3.1.-.-3 |
Export aliases for ZC3H12B gene to outside databasesPrevious GC identifers: GC0XP064492 GC0XP064625 GC0XP058536 |
Summaries
for ZC3H12B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZC3H12B:
The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in theproinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought tofunction as a ribonuclease. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0Function: May function as RNase and regulate the levels of target RNA species (Potential)
|
Genomic Views
for ZC3H12B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZC3H12B gene promoter:
STAT1 GCNF GCNF-1 FOXO1a GCNF-2 FOXO1 En-1 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZC3H12B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H12B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq12 Ensembl cytogenetic band: Xq12 HGNC cytogenetic band: Xq12ZC3H12B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP064708: view genomic region
(about GC identifiers)
Start:
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64,708,615 bp from pter |
End:
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64,727,767 bp from pter |
Size:
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19,153 bases |
Orientation:
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plus strand |
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Proteins
for ZC3H12B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0 (See
protein sequence)Recommended Name: Probable ribonuclease ZC3H12B Size: 825 amino acids; 93046 Da
Cofactor: Magnesium (Potential)
Sequence caution: Sequence=CAI42594.1; Type=Erroneous gene model prediction; Sequence=CAI42834.1; Type=Erroneous genemodel prediction;
Secondary accessions: B2RTQ3 Q5H9C0Alternative splicing: 2 isoforms: Q5HYM0-1 Q5HYM0-2 Explore the universe of human proteins at neXtProt for ZC3H12B: NX_Q5HYM0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5HYM0
ZC3H12B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001010888.3
ENSEMBL proteins: ENSP00000340839 ENSP00000408077
Human Recombinant Protein Products:
ZC3H12B Antibody Products:
Assay Products for ZC3H12B: |
Protein
Domains /
Families
for ZC3H12B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZC3H12B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5HYM0ProtoNet protein and cluster: Q5HYM0 UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0Similarity: Belongs to the ZC3H12 familySimilarity: Contains 1 C3H1-type zinc finger |
Function
for ZC3H12B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0Function: May function as RNase and regulate the levels of target RNA species (Potential)Enzyme Number (IUBMB): EC 3.1.-.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H12B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H12B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZC3H12B for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ZC3H12B:
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Pathways & Interactions
for ZC3H12B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3H12B
|
Drugs & Compounds
for ZC3H12B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZC3H12B
Search CenterWatch for drugs/clinical trials and news about ZC3H12B / ZC12B
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Transcripts
for ZC3H12B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZC3H12B gene: NM_001010888.3 Unigene Cluster for ZC3H12B: Zinc finger CCCH-type containing 12B Hs.21249 [show with all ESTs]Unigene Representative Sequence: NM_0010108882 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338957(uc010nko.3) ENST00000423889
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H12B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC3H12B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZC3H12B (NM_001010888) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZC3H12B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H12B |
Additional cDNA sequence: AK091685.1 BC140767.1 BC171781.1 BX647241.1 3 DOTS entries: DT.40302996 DT.121290870 DT.91840048 24/31 AceView cDNA sequences (see all 31): Z40081 BX647241 CR595814 BX415643 AA393649 AL538134 F01575 AK091685 BU688430 BF218384 AW007160 F10287 BU688472 AI022457 Z44033 F05315 AI139147 BX445086 F12676 W25351 BX478773 BX415642 BX452193 H14594
GeneLoc Exon Structure
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Expression
for ZC3H12B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZC3H12B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGTTTTGTT
About this image
See ZC3H12B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZC3H12B
SOURCE GeneReport for Unigene cluster: Hs.21249
SABiosciences Custom PCR Arrays for ZC3H12B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZC3H12B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZC3H12B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC3H12B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC3H12B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H12B |
Orthologs
for ZC3H12B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for ZC3H12B gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for ZC3H12B (if available)
TreeFam Gene Tree for ZC3H12B (if available) |
Paralogs
for ZC3H12B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZC3H12B gene
- NYNRIN2 ZC3H12C2 N4BP12 ZC3H12D2 KHNYN2 ZC3H12A2
4 SIMAP similar genes for ZC3H12B using alignment to 2 protein entries: ZC12B_HUMAN (see all proteins):ZC3H12D ZC3H12A ZC3H12C KHNYN
ZC3H12B for paralogs About GeneDecksing
|
Genomic Variants
for ZC3H12B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZC3H12B (64708615 - 64727767 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZC3H12B: --
Locus Specific Mutation Databases (LSDB): ZC3H12B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC3H12B |
|
Disorders
/ Diseases
for ZC3H12B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZC3H12B for disorders About MalaCards
ZC3H12B for disorders About GeneDecksing
OMIM gene information: 300889
OMIM disorders: --
Export disorders for ZC3H12B gene to outside databases
|
Publications
for ZC3H12B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZC3H12B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZC3H12B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PubMed id 18178554)1, 2, 3 Liang J....Fu M. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for ZC3H12B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ZC3H12B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZC3H12B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZC3H12B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZC3H12B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZC3H12B gene:
Search GeneIP for patents involving ZC3H12B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZC3H12B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
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 | | | ZC3H12B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H12B |
|  |  |  | | | | ThermoFisher Antibodies for ZC3H12B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H12B |
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