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ZC3H12B Gene

protein-coding GIFtS: 40

GC0XP064625

zinc finger CCCH-type containing 12B
(Previous name: chromosome X open reading frame 32 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CXorf32)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CXorf32 ^², ³
EC 3.1.-.- ^³
MCPIP2 ^¹, ², ³

Descriptions
MCP induced protein 2 ^²
MCP-induced protein 2 ^², ³
Zinc finger CCCH domain-containing protein 12B ^³
chromosome X open reading frame 32 ^¹
zinc finger CCCH-type containing 12B ^²

External Ids
HGNC: 17407¹
Entrez Gene: 340554²
UniProtKB: Q5HYM0³
Ensembl: ENSG00000102053⁷

Search outside databases for aliases for ZC3H12B gene

Previous GC identifer: GC0XP064492

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0

Function: May function as RNase and regulate the levels of target RNA species (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZC3H12B gene

Entrez Gene cytogenetic band: Xq11.1 Ensembl cytogenetic band: Xq11.1 HGNC cytogenetic band: Xq12

ZC3H12B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP064625: (about GC identifiers)

Start:	64,625,431 bp from pter
End:	64,644,492 bp from pter
Size:	19,062 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011669.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0 (See protein sequence)

Recommended Name: Probable ribonuclease ZC3H12B

Size: 772 amino acids; 87384 Da

Cofactor: Magnesium (Potential)

Sequence caution: Sequence=CAI42594.1; Type=Erroneous gene model prediction; Sequence=CAI42834.1;

Type=Erroneous gene model prediction;

Secondary accessions: Q5H9C0

REFSEQ proteins: NP_001010888.2

ENSEMBL proteins:

ENSP00000340839 ENSP00000218172

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	18029348
GO:0005794	Golgi apparatus	IDA	18029348

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Antibodies for ZC3H12B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZC3H12B
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZC3H12B

Assays for ZC3H12B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5HYM0

UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0

Similarity: Belongs to the ZC3H12 family

Similarity: Contains 1 C3H1-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H12B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZC3H12B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_293334

Applied Biosystems Silencer® siRNAs for ZC3H12B

Sigma-Aldrich siRNA for ZC3H12B

Sigma-Aldrich shRNA for ZC3H12B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010888
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010888
untagged cDNA clones in CMV expression vector (see all 2): NM_001010888

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001010888

UniProtKB/Swiss-Prot: ZC12B_HUMAN, Q5HYM0

Function: May function as RNase and regulate the levels of target RNA species (Potential)

Enzyme Number (IUBMB): EC 3.1.-.-

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZC3H12B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H12B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZC3H12B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_293334

Sigma-Aldrich siRNA for ZC3H12B

Sigma-Aldrich shRNA for ZC3H12B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001010888

REFSEQ mRNAs for ZC3H12B gene:

NM_001010888.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001010888

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010888
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010888
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001010888

Additional cDNA sequence:

AK091685.1 BC140767.1 BC171781.1 BX647241.1 CR595814.1

3 DOTS entries:

DT.40302996 DT.121290870 DT.91840048

24/31 AceView cDNA sequences (see all 31 ):

Z40081 BX415643 CR595814 BX647241 F01575 AL538134 AA393649 AK091685

BF218384 AI022457 BX445086 AI139147 W25351 BU688430 F05315 F12676

Z44033 AW007160 BU688472 F10287 BX478773 BX452193 BX415642 H14700

highest scoring ESTs for ZC3H12B:

AW007160 BX647241 AA393649 AI022457 AI139147 AK091685 AL538134 BF218384 BG745356 BU688430

Unigene Cluster for ZC3H12B:

Zinc finger CCCH-type containing 12B

Hs.21249 [show with all ESTs]

Unigene Representative Sequence: NM_001010888

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000338957 ENST00000218172

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ZC3H12B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H12B

¹ / ² / ³

5 probe-sets matching ZC3H12B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
59691_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AW007160	0.80	1.00	0.91	1
234878_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
229234_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW007160	0.80	1.00	0.91	1
234878_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229234_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZC3H12B for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: AGGTTTTGTT

SOURCE GeneReport for Unigene cluster: Hs.21249

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZC3H12B gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZC3H12B¹	--	zinc finger CCCH-type containing 12B	90.28(n) 90.93(a)	491921 XM_549041.2 XP_549041.2
chimpanzee (Pan troglodytes)	ZC3H12B¹	--	zinc finger CCCH-type containing 12B	97.93(n) 97.67(a)	473644 XM_529016.2 XP_529016.2
cow (Bos taurus)	ZC3H12B¹	--	zinc finger CCCH-type containing 12B	91.44(n) 90.53(a)	524199 XM_602520.3 XP_602520.3
mouse (Mus musculus)	Zc3h12b^{1, 5}	X⁵	zinc finger CCCH-type containing 12B^{1, 5}	89.55(n)¹ 90.89(a)¹	547176¹ NM_001034907.2¹ NP_001030079.2¹ AK037591⁵ AK084769⁵ (see all 8)
zebrafish (Danio rerio)	DKEY-286F3.6¹	--	similar to zinc finger CCCH-type containing 12B	64.77(n) 69.14(a)	100002370 XM_001342136.2 XP_001342172.2

About this table Species with no ortholog for ZC3H12B

ENSEMBL Gene Tree for ZC3H12B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZC3H12B gene

ZC3H12C² ZC3H12D² ZC3H12A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/66 NCBI SNPs in ZC3H12B are shown (see all 66 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 20)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2038284^1,2	A,C,F,H,O	64641534(+)	`GTTACT/GCACTT`	1	--	ut3¹ ese³		14		NS EU EA WA NA	800
	rs2038285^1,2	A,C,F,H,O	64642063(+)	`CTATCT/CTCTGA`	1	--	ut3¹ ese³		12		NS EU EA WA NA	640
	rs5964981^1,2	A,C,F,H	64644278(+)	`GTTAAC/TCAGAG`	1	--	ut3¹ ese³		7		EU EA WA NA	531
--	rs2038283^1,2	A,C	64640227(+)	`tctttA/C/Tttttt`	1	--	ut3¹		0	--	--	--	--
	rs4827440^1,2	C	64625007(+)	`GGGTAC/GGGGGG`	1	--	ng5¹		0	--	--	--	--
	rs12014994^1,2	C	64640141(+)	`CCAGGA/GGGAGA`	1	--	ut3¹ ese³ trp³		0	--	--	--	--
	rs12856294^1,2	H	64641936(+)	`GTTGTT/ATCTGG`	1	--	ut3¹ ese³		4		EU EA WA	420
	rs7890060^1,2	H	64644412(+)	`TAATTG/ATGATG`	1	--	ut3¹		4		EU EA WA	414
--	rs5964442^1,2	A,C,F,H	64629079(+)	`GCCAAG/AAAATA`	1	--	int¹		7		EU EA WA NA	533
	rs5964443^1,2	A,F,H	64629112(+)	`ACATAC/TTAAAA`	1	--	int¹		4		EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for ZC3H12B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for ZC3H12B gene:

A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PubMed id 18178554)^{2, 3, 4} Liang J....Fu M. (2008)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)³ Barbe L....Andersson-Svahn H. (2008)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 340554	HGNC: 17407	AceView: CXorf32	Ensembl:ENSG00000102053	euGenes: HUgn340554
ECgene: ZC3H12B	H-InvDB: ZC3H12B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZC3H12B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ZC3H12B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZC3H12B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZC3H12B		Antibodies for ZC3H12B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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ZC3H12B Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for ZC3H12B

Summaries
for ZC3H12B

Genomic Location
for ZC3H12B

Proteins
for ZC3H12B

Protein Domains/
Families
for ZC3H12B

Gene Function
for ZC3H12B

Pathways & Interactions
for ZC3H12B

Drugs & Compounds
for ZC3H12B

Transcripts
for ZC3H12B

Expression
for ZC3H12B

Orthologs
for ZC3H12B

Paralogs
for ZC3H12B

SNPs/Variants
for ZC3H12B

Disorders & Mutations
for ZC3H12B

Medical News
for ZC3H12B

Publications
for ZC3H12B

Search for ZC3H12B

Genome Databases showing ZC3H12B

Other Databases showing ZC3H12B

Specialized Databases showing ZC3H12B

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZC3H12B Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor ZC3H12B

Summariesfor ZC3H12B

Genomic Locationfor ZC3H12B

Proteinsfor ZC3H12B

Protein Domains/Familiesfor ZC3H12B

Gene Functionfor ZC3H12B

Pathways & Interactionsfor ZC3H12B

Drugs & Compoundsfor ZC3H12B

Transcriptsfor ZC3H12B

Expression for ZC3H12B

Orthologsfor ZC3H12B

Paralogsfor ZC3H12B

SNPs/Variantsfor ZC3H12B

Disorders & Mutationsfor ZC3H12B

Medical Newsfor ZC3H12B

Publicationsfor ZC3H12B

Search for ZC3H12B

Genome Databases showing ZC3H12B

Other Databases showing ZC3H12B

Specialized Databases showing ZC3H12B

Licensable Technologiesfor ZC3H12B

Servicesfor ZC3H12B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZC3H12B

Summaries
for ZC3H12B

Genomic Location
for ZC3H12B

Proteins
for ZC3H12B

Protein Domains/
Families
for ZC3H12B

Gene Function
for ZC3H12B

Pathways & Interactions
for ZC3H12B

Drugs & Compounds
for ZC3H12B

Transcripts
for ZC3H12B

Expression
for ZC3H12B

Orthologs
for ZC3H12B

Paralogs
for ZC3H12B

SNPs/Variants
for ZC3H12B

Disorders & Mutations
for ZC3H12B

Medical News
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Licensable Technologies
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