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ZC3H12A Gene

protein-coding   GIFtS: 44

GC01P037712
zinc finger CCCH-type containing 12A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 3.1.-.- 3
FLJ23231 1, 2
MCPIP 2, 3
MCPIP1 1, 2, 3
OTTHUMP00000004398 2
OTTHUMP00000004399 2
RP3-423B22.1 2
dJ423B22.1 2
Descriptions
MCP induced protein 1 2
MCP-1 treatment-induced protein 2
MCP-induced protein 1 2, 3
Zinc finger CCCH domain-containing protein 12A 3
zinc finger CCCH-type containing 12A 2
External Ids
HGNC: 262591
Entrez Gene: 801492
UniProtKB: Q5D1E83
Ensembl: ENSG000001638747
Search outside databases for aliases for ZC3H12A gene

Previous GC identifer: GC01P037611

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ZC3H12A:
ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and
causes cell death of cardiomyocytes, possibly via induction of genes associated with
apoptosis.[supplied by OMIM]

UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8
Function: Has RNase activity and selectively degrades specific target mRNA species. Modulates the
immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes
the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay
of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the
binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZC3H12A gene  

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

ZC3H12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P037712:     (about GC identifiers)

Start:
37,712,706 bp from pter
End:
37,722,565 bp from pter
Size:
9,860 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8 (See protein sequence)
Recommended Name: Ribonuclease ZC3H12A  
Size: 599 amino acids; 65699 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus
Miscellaneous: Increased expression of ZC3H12A is associated with ischemic heart disease
Caution: Was originally (PubMed:18364357) proposed to bind to DNA and act as transcription factor
Secondary accessions: Q6I9Z1 Q9H5P1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_079355.2  

    ENSEMBL proteins: 
    ENSP00000362174 ENSP00000362179 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MCPIP1)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZC3H12A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (MCPIP1), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ZC3H12A

    Assays for ZC3H12A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5D1E8

    UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8
    Similarity: Belongs to the ZC3H12 family
    Similarity: Contains 1 C3H1-type zinc finger

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZC3H12A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZC3H12A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025079

                  Applied Biosystems Silencer® siRNAs for ZC3H12A

                  Sigma-Aldrich siRNA for ZC3H12A  
                         Sigma-Aldrich shRNA for ZC3H12A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_025079
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_025079
                                     untagged cDNA clone in CMV expression vector: NM_025079 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_025079

    UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8
    Function: Has RNase activity and selectively degrades specific target mRNA species. Modulates the
    immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes
    the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay
    of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the
    binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19
    Induction: By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1
    cells
    Enzyme Number (IUBMB): EC 3.1.-.- 

    5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zc3h12a):

    cellulargrowth/sizehematopoietic systemimmune systemlife span-post-weaning/aging

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    3 Interacting proteins for ZC3H12A (ENSP000003621743) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL2ENSP000002258313STRING (score=.967)
    GFAPENSP000002534083STRING (score=.909)
    CCR2ENSP000002923013STRING (score=.716)
    About this table

    5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525 angiogenesis IEA--
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0006915 apoptosis IEA--
    GO:0007275 multicellular organismal development IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZC3H12A

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZC3H12A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZC3H12A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025079

                  Sigma-Aldrich siRNA for ZC3H12A  
                         Sigma-Aldrich shRNA for ZC3H12A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_025079  

    REFSEQ mRNAs for ZC3H12A gene: 

    NM_025079.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_025079  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_025079
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_025079
                                     untagged cDNA clone in CMV expression vector: NM_025079 

    Additional cDNA sequence: 

    AK026884.1 AK093343.1 AY920403.1 BC005001.1 CR457364.1 FJ695517.1 

    9 DOTS entries:

    DT.451660  DT.100783966  DT.92026405  DT.121360856  DT.86845883  DT.91701293  DT.95355975  DT.95364524 
    DT.99967911 

    24/120 AceView cDNA sequences (see all 120 ):

    AI538369 AA909913 AI160574 AA922836 BQ927247 BX953361 AL710798 AW130116 
    BM980772 CD722510 BU540574 CB126802 BC005001 AU280264 BQ691835 AI631181 
    AA640102 AW138503 AI082816 CB131278 AW104766 AK026884 AL602376 AI818610 

    highest scoring ESTs for ZC3H12A:

    AA011633 AA004289 AA004335 AA011632 AA292423 AA477110 AA477355 AA640102 AA669468 AA858323 

    Unigene Cluster for ZC3H12A:

    Zinc finger CCCH-type containing 12A
    Hs.656294  [show with all ESTs]
    Unigene Representative Sequence: NM_025079


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12A

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6
    SP1:                    -                       -           -         
    SP2:                    -                                             
    SP3:                                            -                     
    SP4:                                                                  

    About this scheme

    ECgene alternative splicing isoforms for ZC3H12A

    2 Ensembl transcripts including schematic representations:
    ENST00000373082  ENST00000373087  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZC3H12A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H12A

    1 / 2 / 3

    3 probe-sets matching ZC3H12A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    48766_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AA011633 1.00 1.00 1.00 1

    218810_at2, 3 U133-A 1 1.00 1.00 -- -- NM_025079 0.60 1.00 0.82 1

    218810_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.656294
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZC3H12A gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZC3H12A1   -- zinc finger CCCH-type containing 12A 83.04(n)
    83.33(a)
    608211  XM_845170.1  XP_850263.1 
    chimpanzee
    (Pan troglodytes)
    ZC3H12A1   -- zinc finger CCCH-type containing 12A 99.17(n)
    99(a)
    456757  XM_001169017.1  XP_001169017.1 
    cow
    (Bos taurus)
    ZC3H12A1   -- zinc finger CCCH-type containing 12A 85.39(n)
    86.51(a)
    535344  XM_615404.3  XP_615404.3 
    rat
    (Rattus norvegicus)
    Zc3h12a1   -- zinc finger CCCH type containing 12A 81.99(n)
    82.89(a)
    313587  XM_233517.4  XP_233517.3 
    mouse
    (Mus musculus)
    Zc3h12a1, 5 45
    zinc finger CCCH type containing 12A1, 5 81.21(n)1
    82.72(a)1
    2307381  NM_153159.11  NP_694799.11 
     AK1425015  AK1496985  (see all 16)
    About this table        Species with no ortholog for ZC3H12A

    ENSEMBL Gene Tree for ZC3H12A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZC3H12A gene
    ZC3H12C2  ZC3H12B2  ZC3H12D2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/31 NCBI SNPs in ZC3H12A are shown (see all 31 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 43)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs168241791,2
    C,F,H37719923(+) GGATCG/ATGGTT 1 M/V mis1 ese37Minor allele frequency- A:0.01NA EU EA WA 548
    rs120457541,2
    H37722876(+) TTTATC/GTGCAA 1 -- ng313Minor allele frequency- G:0.00EA WA 296
    rs115898931,2
    A,C,F,H37719442(+) ATTCAC/TGGACC 1 -- int112Minor allele frequency- N:0.00EU EA WA NA 1050
    rs2152051,2
    A,C,F,H37720799(+) GTGCCC/GTGTTT 1 -- int18Minor allele frequency- G:0.29EA NA EU WA 568
    --
    rs112640601,2
    A,C,F37717093(+) CCCTGA/GGCTGG 1 -- int14Minor allele frequency- G:0.44EA NA 216
    rs13957191,2
    H37719069(+) tgcctT/Acctcg 1 -- int14Minor allele frequency- A:0.00EU EA WA 420
    rs2152041,2
    H37716199(+) TAGTTC/GCCAGT 1 -- int14Minor allele frequency- G:0.00EU EA WA 412
    rs120379501,2
    H37717063(+) TGGCAG/AAGGGA 1 -- int14Minor allele frequency- A:0.00EU EA WA 414
    rs124089931,2
    C37715676(+) ACCCCC/GCCTCC 1 -- int1 trp30--------
    --
    rs10522251,2
    --37722055(+) AGTTTA/CAGGAG 1 -- ut31 ese31Minor allele frequency- C:0.00MN 184
    About this table

    HapMap Linkage Disequilibrium images for ZC3H12A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610562

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/12 PubMed articles for ZC3H12A gene (see all 12 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 80149 HGNC: 26259 AceView: FLJ23231 Ensembl:ENSG00000163874 euGenes: HUgn80149
    ECgene: ZC3H12A H-InvDB: ZC3H12A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZC3H12A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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