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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZC3H12A Gene

protein-coding   GIFtS: 49
GCID: GC01P037940

Zinc Finger CCCH-Type Containing 12A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger CCCH-Type Containing 12A1 2     RP3-423B22.12
MCP Induced Protein 11 2     dJ423B22.12
Zinc Finger CCCH Domain-Containing Protein 12A2 3     MCP-1 Treatment-Induced Protein2
MCPIP2 3     Ribonuclease ZC3H12A2
MCPIP12 3     EC 3.1.-.-3
MCP-Induced Protein 12 3     

External Ids:    HGNC: 262591   Entrez Gene: 801492   Ensembl: ENSG000001638747   OMIM: 6105625   UniProtKB: Q5D1E83   

Export aliases for ZC3H12A gene to outside databases

Previous GC identifers: GC01P037611 GC01P037712 GC01P036058


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZC3H12A Gene:
ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell
death of cardiomyocytes, possibly via induction of genes associated with apoptosis.(supplied by OMIM, Mar 2008)

GeneCards Summary for ZC3H12A Gene: 
ZC3H12A (zinc finger CCCH-type containing 12A) is a protein-coding gene. Diseases associated with ZC3H12A include acute monocytic leukemia, and monocytic leukemia. GO annotations related to this gene include metal ion binding and endonuclease activity. An important paralog of this gene is NYNRIN.

UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8
Function: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response
and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR)
of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis
and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZC3H12A gene promoter:
         Max1   c-Fos   GATA-3   Tal-1   AP-1   E47   PPAR-gamma1   c-Myb   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC3H12A promoter sequence
   Search SABiosciences Chromatin IP Primers for ZC3H12A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

ZC3H12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3H12A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P037940:  view genomic region     (about GC identifiers)

Start:
37,940,119 bp from pter      End:
37,949,980 bp from pter
Size:
9,862 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8 (See protein sequence)
Recommended Name: Ribonuclease ZC3H12A  
Size: 599 amino acids; 65699 Da
Cofactor: Magnesium
Subcellular location: Cytoplasm (By similarity). Nucleus
Miscellaneous: Increased expression of ZC3H12A is associated with ischemic heart disease
Caution: Was originally (PubMed:18364357) proposed to bind to DNA and act as transcription factor
3 PDB 3D structures from and Proteopedia for ZC3H12A:
3V32 (3D)        3V33 (3D)        3V34 (3D)    
Secondary accessions: D3DPT0 Q6I9Z1 Q9H5P1

Explore the universe of human proteins at neXtProt for ZC3H12A: NX_Q5D1E8

Explore proteomics data for ZC3H12A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5D1E8

  • ZC3H12A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZC3H12A Protein Expression
    REFSEQ proteins: NP_079355.2  
    ENSEMBL proteins: 
     ENSP00000362179   ENSP00000473447  

    Human Recombinant Protein Products for ZC3H12A: 
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    Cloud-Clone Corp. Proteins for ZC3H12A 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    ZC3H12A for ontologies           About GeneDecksing



    ZC3H12A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC3H: Zinc fingers, CCCH-type domain containing

    1 InterPro protein domain:
     IPR021869 RNase_Zc3h12

    Graphical View of Domain Structure for InterPro Entry Q5D1E8

    ProtoNet protein and cluster: Q5D1E8

    UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8
    Similarity: Belongs to the ZC3H12 family
    Similarity: Contains 1 C3H1-type zinc finger


    ZC3H12A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZC12A_HUMAN, Q5D1E8
    Function: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response
    and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR)
    of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis
    and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19
    Induction: By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004519endonuclease activity IEA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    ZC3H12A for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zc3h12a):
     cellular  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging 

    ZC3H12A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zc3h12atm1Aki for ZC3H12A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZC3H12A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZC3H12A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZC3H12A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZC3H12A 

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ZC3H12A (see all 15):
    hsa-miR-4271 hsa-miR-3194-5p hsa-miR-642a hsa-miR-139-5p hsa-miR-3653 hsa-miR-3157-5p hsa-miR-888* hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidZC3H12A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H12A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3H12A

    5/7 Interacting proteins for ZC3H12A (Q5D1E81, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AIMP2Q131552, 3MINT-8259029 I2D: score=2 
    BTRCQ9Y2972, 3MINT-8249762 I2D: score=2 
    IRAK2O431871, 3EBI-747793,EBI-447733 I2D: score=1 
    AHSPQ9NZD43I2D: score=4 
    TANKQ928443I2D: score=4 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006915apoptotic process IEA--
    GO:0010508positive regulation of autophagy IDA--
    GO:0010628positive regulation of gene expression IDA--
    GO:0010629negative regulation of gene expression IDA18178554

    ZC3H12A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZC3H12A (ZC12A)

    Search CenterWatch for drugs/clinical trials and news about ZC3H12A / ZC12A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZC3H12A gene: 
    NM_025079.2  

    Unigene Cluster for ZC3H12A:

    Zinc finger CCCH-type containing 12A
    Hs.656294  [show with all ESTs]
    Unigene Representative Sequence: NM_025079
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373087(uc001cbb.4) ENST00000472312 ENST00000471012
    miRNA
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    hsa-miR-4271 hsa-miR-3194-5p hsa-miR-642a hsa-miR-139-5p hsa-miR-3653 hsa-miR-3157-5p hsa-miR-888* hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidZC3H12A 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC3H12A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC3H12A

    Additional mRNA sequence: 

    AK026884.1 AK093343.1 AY920403.1 BC005001.1 CR457364.1 FJ695517.1 

    9 DOTS entries:

    DT.451660  DT.100783966  DT.92026405  DT.121360856  DT.86845883  DT.95355975  DT.91701293  DT.95364524 
    DT.99967911 

    24/120 AceView cDNA sequences (see all 120):

    AW104766 AW138503 AW130116 AI160574 CD722510 AL710798 BQ927247 BU540574 
    CB126802 BQ691835 AI538369 AA640102 CB131278 AU280264 BM980772 AI631181 
    BC005001 AA922836 AA909913 BX953361 AI082816 BG333133 AW206332 NM_025079 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6
    SP1:                    -                       -           -         
    SP2:                    -                                             
    SP3:                                            -                     
    SP4:                                                                  


    ECgene alternative splicing isoforms for ZC3H12A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZC3H12A expression in normal human tissues (normalized intensities)      ZC3H12A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZC3H12A Expression
    About this image


    ZC3H12A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Extraembryonic Tissues)    fully expand to see all 3 entries
             Cord Blood CD133- Cells   
             clps   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Cord Blood CD133- Cells   
     
     Adipose (Muscoskeletal System)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)

    See ZC3H12A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZC3H12A

    SOURCE GeneReport for Unigene cluster: Hs.656294
        SABiosciences Custom PCR Arrays for ZC3H12A
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZC3H12A gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc3h12a1 , 5 zinc finger CCCH type containing 12A1, 5 81.21(n)1
    82.72(a)1
      4 (58.10 cM)5
    2307381  NM_153159.21  NP_694799.11 
     1251184235 
    chicken
    (Gallus gallus)
    Aves ZC3H12A1 zinc finger CCCH-type containing 12A 65.08(n)
    65.2(a)
      419618  XM_417765.3  XP_417765.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZC3H12A6
    Uncharacterized protein
    54(a)
    1 ↔ 1
    GL343426.1(412692-429478)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-206d17.121 si:dkey-206d17.12 56.66(n)
    54.78(a)
      563108  NM_001171029.1  NP_001164500.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG108896
    --
    33(a)
    1 → many
    3R(15859603-15861777)
    worm
    (Caenorhabditis elegans)
    Secernentea C30F12.16
    Protein C30F12.1
    26(a)
    1 → many
    I(6954411-6961139)


    ENSEMBL Gene Tree for ZC3H12A (if available)
    TreeFam Gene Tree for ZC3H12A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZC3H12A gene
    NYNRIN2  ZC3H12C2  N4BP12  ZC3H12B2  ZC3H12D2  KHNYN2  
    3 SIMAP similar genes for ZC3H12A using alignment to 3 protein entries:     ZC12A_HUMAN (see all proteins):
    ZC3H12B    ZC3H12D    ZC3H12C

    ZC3H12A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZC3H12A
    PGOHUM00000241157


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/234 SNPs in ZC3H12A are shown (see all 234)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869036891,2
    --37942189(+) CCTGGA/GCTGGA 1 -- int10--------
    rs1490632701,2
    --37942441(+) GAAAAC/GTTCCT 1 -- int10--------
    rs1430973731,2
    --37942448(+) TCCTGC/TTGGCA 1 -- int10--------
    rs1905573831,2
    --37942608(+) CTGGCC/GCTGGC 1 -- int10--------
    rs1154920891,2
    C,F--37942764(+) GCTTCG/AAGATT 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1830022001,2
    --37942795(+) TCCAGC/TCTCAT 1 -- int10--------
    rs1885690391,2
    --37942825(+) GGTTGG/TATCTG 1 -- int10--------
    rs1931482191,2
    --37942851(+) TGGAGA/GTATGG 1 -- int10--------
    rs1133228751,2
    C,F--37942984(+) AGAGCC/TACGCA 1 -- int13Minor allele frequency- T:0.05CSA WA 121
    rs1856426721,2
    --37943045(+) CCTCAA/TACTTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZC3H12A (37940119 - 37949980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZC3H12A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv483134CNV Loss15286789

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610562    OMIM disorders: --

    5 diseases for ZC3H12A:    About MalaCards
    acute monocytic leukemia    monocytic leukemia    acne    ischemic heart disease
    leukemia


    ZC3H12A for disorders           About GeneDecksing


    Export disorders for ZC3H12A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZC3H12A gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with ZC3H12A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PubMed id 18178554)1, 2, 3 Liang J....Fu M. (2008)
    2. MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. (PubMed id 22055188)1, 3 Suzuki H.I....Miyazono K. (2011)
    3. Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP). (PubMed id 18364357)1, 2 Niu J.... Kolattukudy P.E. (2008)
    4. Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. (PubMed id 16574901)1, 2 Zhou L.... Kolattukudy P.E. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Regulatory feedback loop between NF-kappaB and MCP-1- induced protein 1 RNase. (PubMed id 19747262)1, 9 Skalniak L....Jura J. (2009)
    7. Interleukin-17 (IL-17) and IL-1 activate translation o f overlapping sets of mRNAs, including that of the negative regulator of inflamm ation, MCPIP1. (PubMed id 23658019)1 Dhamija S....Holtmann H. (2013)
    8. MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation. (PubMed id 23355615)1 Lin R.J....Lin Y.L. (2013)
    9. Monocyte chemotactic protein-induced protein (MCPIP) p romotes inflammatory angiogenesis via sequential induction of oxidative stress, endoplasmic reticulum stress and autophagy. (PubMed id 22820500)1 Roy A. and Kolattukudy P.E. (2012)
    10. Structural study of MCPIP1 N-terminal conserved domain reveals a PIN- like RNase. (PubMed id 22561375)2 Xu J.... Rao Z. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80149 HGNC: 26259 AceView: FLJ23231 Ensembl:ENSG00000163874 euGenes: HUgn80149
    ECgene: ZC3H12A H-InvDB: ZC3H12A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZC3H12A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZC3H12A gene:
    Search GeneIP for patents involving ZC3H12A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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