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Aliases for ZC3H12A Gene

Aliases for ZC3H12A Gene

  • Zinc Finger CCCH-Type Containing 12A 2 3 5
  • Monocyte Chemotactic Protein-Induced Protein 1 3 4
  • Zinc Finger CCCH Domain-Containing Protein 12A 3 4
  • MCP-Induced Protein 1 3 4
  • Regnase-1 3 4
  • MCPIP-1 3 4
  • MCPIP1 3 4
  • MCPIP 3 4
  • Reg1 3 4
  • Bifunctional Endoribonuclease And Deubiquitinase ZC3H12A 3
  • MCP-1 Treatment-Induced Protein 3
  • Endoribonuclease ZC3H12A 3
  • MCP Induced Protein 1 2
  • Ribonuclease ZC3H12A 3
  • DJ423B22.1 3
  • EC 3.1.-.- 4

External Ids for ZC3H12A Gene

Previous GeneCards Identifiers for ZC3H12A Gene

  • GC01P037611
  • GC01P037712
  • GC01P037940
  • GC01P036058

Summaries for ZC3H12A Gene

Entrez Gene Summary for ZC3H12A Gene

  • ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]

GeneCards Summary for ZC3H12A Gene

ZC3H12A (Zinc Finger CCCH-Type Containing 12A) is a Protein Coding gene. GO annotations related to this gene include endonuclease activity. An important paralog of this gene is ZC3H12C.

UniProtKB/Swiss-Prot for ZC3H12A Gene

  • Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:26320658, PubMed:26134560, PubMed:22561375). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at Lys-48- and Lys-63-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (By similarity).

  • (Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs (PubMed:23355615). Binds to Japanese encephalitis virus (JEV) and dengue virus (DEN) RNAs (PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species (PubMed:24191027).

Additional gene information for ZC3H12A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H12A Gene

Genomics for ZC3H12A Gene

Regulatory Elements for ZC3H12A Gene

Enhancers for ZC3H12A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H037470 2.1 FANTOM5 Ensembl ENCODE dbSUPER 46.9 +5.9 5909 18 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZC3H12A LINC01137 MTF1 SNIP1 GNL2 DNALI1 SF3A3 FTH1P1 MEAF6 YRDC
GH01H037850 1.6 FANTOM5 Ensembl ENCODE dbSUPER 25.9 +378.4 378446 3 SOX6 HLF CEBPB CEBPG ZNF316 GATA2 ZNF366 NR2C1 HMBOX1 ZNF24 MTF1 INPP5B ZC3H12A YRDC C1orf122 ENSG00000233728 SNIP1 RPS2P13
GH01H037845 1.2 FANTOM5 Ensembl 28.9 +372.9 372946 2 PKNOX1 IRF2 ZNF316 GATA2 STAT2 TRIM24 NFE2 IKZF2 MTA2 CEBPB MTF1 ZC3H12A YRDC C1orf122 ENSG00000233728 C1orf109 CDCA8 FHL3 SNIP1 RPS2P13
GH01H037825 0.7 FANTOM5 Ensembl 25.3 +352.1 352146 0 EGR1 MTF1 INPP5B ZC3H12A ENSG00000230955 ENSG00000233728 SNIP1 YRDC GC01M037827 PIR39326 RPS2P13
GH01H037552 1.1 ENCODE 10.2 +80.4 80419 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 SNIP1 C1orf109 SF3A3 GNL2 FTH1P1 YRDC INPP5B CDCA8 ZC3H12A RSPO1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC3H12A on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H12A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004852 1245 2201 ATF1 MLX ARNT ARID4B SIN3A GLI4 YY1 GLIS2 ELK1 ZNF143

Genomic Location for ZC3H12A Gene

Chromosome:
1
Start:
37,473,455 bp from pter
End:
37,484,379 bp from pter
Size:
10,925 bases
Orientation:
Plus strand

Genomic View for ZC3H12A Gene

Genes around ZC3H12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H12A Gene

Proteins for ZC3H12A Gene

  • Protein details for ZC3H12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5D1E8-ZC12A_HUMAN
    Recommended name:
    Endoribonuclease ZC3H12A
    Protein Accession:
    Q5D1E8
    Secondary Accessions:
    • D3DPT0
    • Q6I9Z1
    • Q9H5P1

    Protein attributes for ZC3H12A Gene

    Size:
    599 amino acids
    Molecular mass:
    65699 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Oligomer (PubMed:22055188, PubMed:23355615). Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination (PubMed:25861989). Interacts with IKBKG; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TANK; this interaction increases in response to DNA damage and serves as a bridge to anchor both TANK and USP10 into a deubiquitinating complex (PubMed:25861989). Interacts with TRAF6; this interaction increases in response to DNA damage and is stimulated by TANK (PubMed:25861989). Interacts with USP10; this interaction increases in response to DNA damage and serves as a bridge to anchor both TANK and USP10 into a deubiquitinating complex (PubMed:25861989). Interacts with ZC3H12D (PubMed:26134560). Interacts with TNRC6A (PubMed:26134560). Interacts with IKBKB/IKKB (PubMed:22037600). Interacts with IKBKB/IKKB. Interacts with BTRC; the interaction occurs when ZC3H12A is phosphorylated in a IKBKB/IKKB-dependent manner (By similarity). Interacts with IRAK1; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (By similarity). Interacts with UPF1; this interaction occurs in a mRNA translationally active- and termination-dependent manner and is essential for ZC3H12A-mediated degradation of target mRNAs (By similarity). Associates with ribosomes (By similarity). Interacts with ubiquitin (By similarity).
    • (Microbial infection) Oligomerization is necessary for antiviral activity (PubMed:23355615).

    Three dimensional structures from OCA and Proteopedia for ZC3H12A Gene

neXtProt entry for ZC3H12A Gene

Post-translational modifications for ZC3H12A Gene

  • (Microbial infection) Rapidly degraded in activated T-cells in response to phorbol 13-acetate 12-myristate (PMA) during HIV-1 viral infection (PubMed:24191027).
  • Phosphorylated by IRAK1; phosphorylation is necessary for subsequent phosphorylation by the I-kappa-B-kinase (IKK) complex. Phosphorylated by I-kappa-B-kinase (IKK) subunits IKBKB/IKKB and CHUK/IKKA at Ser-438 and Ser-442; these phosphorylations promote ubiquitin proteasome-mediated degradation of ZC3H12A and hence facilitates rapid and robust production of IL-6 mRNA in response to toll-like receptor (TLR) or IL-1 receptor stimuli (By similarity).
  • Proteolytically cleaved between Arg-111 and Arg-214 by MALT1 in activated T-cells; cleavage at Arg-111 is critical for promoting ZC3H12A degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling T-cell activation (By similarity).
  • Ubiquitinated; ubiquitination is induced in response to interleukin IL1 receptor stimuli in a IKBKB/IKKB and IRAK1-dependent manner, leading to proteasome-mediated degradation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H12A Gene

No data available for DME Specific Peptides for ZC3H12A Gene

Domains & Families for ZC3H12A Gene

Gene Families for ZC3H12A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZC3H12A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC3H12A Gene

Graphical View of Domain Structure for InterPro Entry

Q5D1E8

UniProtKB/Swiss-Prot:

ZC12A_HUMAN :
  • The C3H1-type zinc finger domain and C-terminal region are necessary for pre-miRNA binding (PubMed:22055188). The C-terminal region and proline-rich domain are necessary for oligomerization (PubMed:22055188).
  • Belongs to the ZC3H12 family.
Domain:
  • The C3H1-type zinc finger domain and C-terminal region are necessary for pre-miRNA binding (PubMed:22055188). The C-terminal region and proline-rich domain are necessary for oligomerization (PubMed:22055188).
  • (Microbial infection) The C3H1-type zinc finger domain is necessary for JEV and DEN viral RNA-binding and antiviral activity (PubMed:23355615).
Family:
  • Belongs to the ZC3H12 family.
genes like me logo Genes that share domains with ZC3H12A: view

Function for ZC3H12A Gene

Molecular function for ZC3H12A Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:26320658, PubMed:26134560, PubMed:22561375). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at Lys-48- and Lys-63-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs (PubMed:23355615). Binds to Japanese encephalitis virus (JEV) and dengue virus (DEN) RNAs (PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species (PubMed:24191027).
UniProtKB/Swiss-Prot Induction:
Up-regulated by the transcription factor ELK1 in a interleukin IL1B-dependent manner through activation of the NF-kappa-B and ERK signaling pathways (PubMed:19747262, PubMed:20137095, PubMed:22037600). Up-regulated by chemokine CCL2 in endothelial cells and in peripheral blood monocytes (PubMed:16574901, PubMed:18364357). Up-regulated in activated T lymphocytes (PubMed:23185455). Up-regulated by phorbol 12-myristate 13-acetate (PMA) in primary T lymphocytes (PubMed:19909337, PubMed:23185455). Up-regulated by interleukin IL17 in keratinocytes (PubMed:26320658). Up-regulated by lipopolysaccharide (LPS) (PubMed:19909337). Up-regulated by tumor necrosis factor TNF-alpha and interleukin IL1 in acute monocytic leukemia cell line THP-1 cells (PubMed:18178554, PubMed:19909337). Up-regulated by amyloid precursor protein (APP) (PubMed:19185603).
UniProtKB/Swiss-Prot Induction:
(Microbial infection) Up-regulated in response to Japanese encephalitis virus (JEV) and dengue virus (DEN) infections (PubMed:23355615).

Enzyme Numbers (IUBMB) for ZC3H12A Gene

Phenotypes From GWAS Catalog for ZC3H12A Gene

Gene Ontology (GO) - Molecular Function for ZC3H12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA,IEA 18364357
GO:0003682 chromatin binding IDA 18364357
GO:0003723 RNA binding IDA,IEA 23355615
GO:0003729 mRNA binding IDA 19909337
GO:0003730 mRNA 3-UTR binding ISS,IEA --
genes like me logo Genes that share ontologies with ZC3H12A: view
genes like me logo Genes that share phenotypes with ZC3H12A: view

Animal Models for ZC3H12A Gene

MGI Knock Outs for ZC3H12A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZC3H12A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZC3H12A Gene

Localization for ZC3H12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H12A Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Rough endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule. Note=Predominantly localized in the cytoplasm. Colocalizes with GW182 on many granule-like structures, probably corresponding to cytoplasmic GW bodies (GWBs), also called processing bodies (P bodies). Colocalizes with calnexin on the surface of the rough endoplasmic reticulum (RER) membrane and with translationally active polysomes (By similarity). Colocalizes with ZC3H12D in cytoplasmic mRNA processing P-body, also known as GW bodies (GWBs) (PubMed:22055188, PubMed:26134560). {ECO:0000269 PubMed:22055188, ECO:0000269 PubMed:26134560}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC3H12A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
endoplasmic reticulum 5
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZC3H12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA,IDA 22055188
GO:0005634 nucleus IDA,IEA 16574901
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 18178554
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with ZC3H12A: view

Pathways & Interactions for ZC3H12A Gene

SuperPathways for ZC3H12A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay ISS --
GO:0001525 angiogenesis IEA --
GO:0001933 negative regulation of protein phosphorylation IEA,ISS --
GO:0002230 positive regulation of defense response to virus by host IDA 23355615
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with ZC3H12A: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H12A Gene

Drugs & Compounds for ZC3H12A Gene

No Compound Related Data Available

Transcripts for ZC3H12A Gene

Unigene Clusters for ZC3H12A Gene

Zinc finger CCCH-type containing 12A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZC3H12A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for ZC3H12A Gene

GeneLoc Exon Structure for
ZC3H12A
ECgene alternative splicing isoforms for
ZC3H12A

Expression for ZC3H12A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC3H12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZC3H12A Gene

This gene is overexpressed in Whole Blood (x5.3) and Skin - Not Sun Exposed (Suprapubic) (x4.0).

Protein differential expression in normal tissues from HIPED for ZC3H12A Gene

This gene is overexpressed in Pancreatic juice (35.7), Blymphocyte (16.0), Peripheral blood mononuclear cells (10.1), and CD8 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZC3H12A Gene



Protein tissue co-expression partners for ZC3H12A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC3H12A Gene:

ZC3H12A

SOURCE GeneReport for Unigene cluster for ZC3H12A Gene:

Hs.656294

mRNA Expression by UniProt/SwissProt for ZC3H12A Gene:

Q5D1E8-ZC12A_HUMAN
Tissue specificity: Expressed in heart, placenta, spleen, kidney, liver and lung (PubMed:19909337). Expressed in leukocytes (PubMed:19909337). Expressed in monocyte (PubMed:16574901).

Evidence on tissue expression from TISSUES for ZC3H12A Gene

  • Lung(2.9)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with ZC3H12A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC3H12A Gene

Orthologs for ZC3H12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H12A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H12A 33 34
  • 98.78 (n)
cow
(Bos Taurus)
Mammalia ZC3H12A 33 34
  • 85.53 (n)
dog
(Canis familiaris)
Mammalia ZC3H12A 33 34
  • 82.75 (n)
rat
(Rattus norvegicus)
Mammalia Zc3h12a 33
  • 81.99 (n)
mouse
(Mus musculus)
Mammalia Zc3h12a 33 16 34
  • 81.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC3H12A 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H12A 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H12A 33 34
  • 64.71 (n)
lizard
(Anolis carolinensis)
Reptilia ZC3H12A 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498589 33
  • 63.93 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC798235 33
  • 53.17 (n)
zc3h12a 34
  • 50 (a)
OneToMany
ZC3H12A (2 of 2) 34
  • 46 (a)
OneToMany
Species where no ortholog for ZC3H12A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H12A Gene

ENSEMBL:
Gene Tree for ZC3H12A (if available)
TreeFam:
Gene Tree for ZC3H12A (if available)

Paralogs for ZC3H12A Gene

Paralogs for ZC3H12A Gene

(3) SIMAP similar genes for ZC3H12A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZC3H12A Gene

genes like me logo Genes that share paralogs with ZC3H12A: view

Variants for ZC3H12A Gene

Sequence variations from dbSNP and Humsavar for ZC3H12A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000033213 -- 37,474,159(+) CGATG(C/G)GCACC nc-transcript-variant, upstream-variant-2KB
rs1000380123 -- 37,483,876(+) AGACG(C/G)TGCCG nc-transcript-variant, utr-variant-3-prime
rs1000490301 -- 37,477,676(+) CTTCT(A/G)CACAC intron-variant
rs1000563166 -- 37,479,065(+) AAAGA(A/C)ACCCA intron-variant, upstream-variant-2KB
rs1000635299 -- 37,478,835(+) CAGCA(A/T)ATGGG intron-variant, upstream-variant-2KB

Variation tolerance for ZC3H12A Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H12A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC3H12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZC3H12A Gene

Disorders for ZC3H12A Gene

UniProtKB/Swiss-Prot

ZC12A_HUMAN
  • Note=Increased expression of ZC3H12A is associated with ischemic heart disease (PubMed:16574901). {ECO:0000269 PubMed:16574901}.

Relevant External Links for ZC3H12A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H12A

No disorders were found for ZC3H12A Gene.

No data available for MalaCards and Genatlas for ZC3H12A Gene

Publications for ZC3H12A Gene

  1. MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. (PMID: 22055188) Suzuki HI … Miyazono K (Molecular cell 2011) 2 3 4 60
  2. Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase. (PMID: 19747262) Skalniak L … Jura J (The FEBS journal 2009) 3 4 22 60
  3. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PMID: 18178554) Liang J … Fu M (The Journal of biological chemistry 2008) 2 3 4 60
  4. Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation. (PMID: 26134560) Huang S … Fu M (The Journal of biological chemistry 2015) 3 4 60
  5. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. (PMID: 25861989) Wang W … Wu ZH (The Journal of biological chemistry 2015) 3 4 60

Products for ZC3H12A Gene

Sources for ZC3H12A Gene

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