Aliases for ZC3H12A Gene
External Ids for ZC3H12A Gene
Previous GeneCards Identifiers for ZC3H12A Gene
ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]
GeneCards Summary for ZC3H12A Gene
ZC3H12A (Zinc Finger CCCH-Type Containing 12A) is a Protein Coding gene. GO annotations related to this gene include endonuclease activity. An important paralog of this gene is N4BP1.
UniProtKB/Swiss-Prot for ZC3H12A Gene
Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.