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Aliases for ZC3H12A Gene

Aliases for ZC3H12A Gene

  • Zinc Finger CCCH-Type Containing 12A 2 3 5
  • MCPIP1 3 4
  • MCPIP 3 4
  • Zinc Finger CCCH Domain-Containing Protein 12A 3
  • MCP-1 Treatment-Induced Protein 3
  • MCP Induced Protein 1 2
  • MCP-Induced Protein 1 3
  • Ribonuclease ZC3H12A 3
  • DJ423B22.1 3

External Ids for ZC3H12A Gene

Previous GeneCards Identifiers for ZC3H12A Gene

  • GC01P037611
  • GC01P037712
  • GC01P037940
  • GC01P036058

Summaries for ZC3H12A Gene

Entrez Gene Summary for ZC3H12A Gene

  • ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]

GeneCards Summary for ZC3H12A Gene

ZC3H12A (Zinc Finger CCCH-Type Containing 12A) is a Protein Coding gene. GO annotations related to this gene include endonuclease activity. An important paralog of this gene is N4BP1.

UniProtKB/Swiss-Prot for ZC3H12A Gene

  • Bifunctional enzyme with both endoribonuclease and deubiquitinase activities involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:26320658, PubMed:26134560, PubMed:22561375). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Functions as a deubiquitinase that affects the overall ubiquitination of cellular proteins (By similarity). Possesses deubiquitinase activity that specifically cleaves Lys-48- and Lys-63-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulates macrophage-mediated inflammatory response and immune homeostasis (By similarity). Deubiquitinates also the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation, which may be dependent on its deubiquitinase activity (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state, depending on both endoribonuclease and deubiquitinase activities (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (By similarity).

  • (Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs (PubMed:23355615). Binds to Japanese encephalitis virus (JEV) and dengue virus (DEN) RNAs (PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species (PubMed:24191027).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H12A Gene

Genomics for ZC3H12A Gene

Regulatory Elements for ZC3H12A Gene

Enhancers for ZC3H12A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZC3H12A on UCSC Golden Path with GeneCards custom track

Promoters for ZC3H12A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZC3H12A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC3H12A Gene

Chromosome:
1
Start:
37,473,455 bp from pter
End:
37,484,379 bp from pter
Size:
10,925 bases
Orientation:
Plus strand

Genomic View for ZC3H12A Gene

Genes around ZC3H12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H12A Gene

Proteins for ZC3H12A Gene

  • Protein details for ZC3H12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5D1E8-ZC12A_HUMAN
    Recommended name:
    Bifunctional endoribonuclease and deubiquitinase ZC3H12A
    Protein Accession:
    Q5D1E8
    Secondary Accessions:
    • D3DPT0
    • Q6I9Z1
    • Q9H5P1

    Protein attributes for ZC3H12A Gene

    Size:
    599 amino acids
    Molecular mass:
    65699 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Oligomer (PubMed:22055188, PubMed:23355615). Interacts with ZC3H12D (PubMed:26134560). Interacts with TNRC6A (PubMed:26134560). Interacts with IKBKB/IKKB (PubMed:22037600). Interacts with IKBKB/IKKB. Interacts with BTRC; the interaction occurs when ZC3H12A is phosphorylated in a IKBKB/IKKB-dependent manner (By similarity). Interacts with IRAK1; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (By similarity). Interacts with UPF1; this interaction occurs in a mRNA translationally active- and termination-dependent manner and is essential for ZC3H12A-mediated degradation of target mRNAs (By similarity). Associates with ribosomes (By similarity). Interacts with ubiquitin (By similarity).
    • (Microbial infection) Oligomerization is necessary for antiviral activity (PubMed:23355615).

    Three dimensional structures from OCA and Proteopedia for ZC3H12A Gene

neXtProt entry for ZC3H12A Gene

Proteomics data for ZC3H12A Gene at MOPED

Post-translational modifications for ZC3H12A Gene

  • (Microbial infection) Rapidly degraded in activated T cells in response to phorbol 13-acetate 12-myristate (PMA) during HIV-1 viral infection (PubMed:24191027).
  • Phosphorylated by IRAK1; phosphorylation is necessary for subsequent phosphorylation by the I-kappa-B-kinase (IKK) complex. Phosphorylated by I-kappa-B-kinase (IKK) subunits IKBKB/IKKB and CHUK/IKKA at Ser-438 and Ser-442; these phosphorylations promote ubiquitin proteasome-mediated degradation of ZC3H12A and hence facilitates rapid and robust production of IL-6 mRNA in response to toll-like receptor (TLR) or IL-1 receptor stimuli (By similarity).
  • Proteolytically cleaved between Arg-111 and Arg-214 by MALT1 in activated T cells; cleavage at Arg-111 is critical for promoting ZC3H12A degradation in response to T cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling T cell activation (By similarity).
  • Ubiquitinated; ubiquitination is induced in response to interleukin IL1 receptor stimuli in a IKBKB/IKKB and IRAK1-dependent manner, leading to proteasome-mediated degradation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H12A Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZC3H12A

No data available for DME Specific Peptides for ZC3H12A Gene

Domains & Families for ZC3H12A Gene

Gene Families for ZC3H12A Gene

Protein Domains for ZC3H12A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC3H12A Gene

Graphical View of Domain Structure for InterPro Entry

Q5D1E8

UniProtKB/Swiss-Prot:

ZC12A_HUMAN :
  • The C3H1-type zinc finger domain and C-terminal region are necessary for pre-miRNA binding (PubMed:22055188). The C-terminal region and proline-rich domain are necessary for oligomerization (PubMed:22055188).
  • Belongs to the ZC3H12 family.
  • Contains 1 C3H1-type zinc finger.
Domain:
  • The C3H1-type zinc finger domain and C-terminal region are necessary for pre-miRNA binding (PubMed:22055188). The C-terminal region and proline-rich domain are necessary for oligomerization (PubMed:22055188).
  • (Microbial infection) The C3H1-type zinc finger domain is necessary for JEV and DEN viral RNA-binding and antiviral activity (PubMed:23355615).
Family:
  • Belongs to the ZC3H12 family.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with ZC3H12A: view

Function for ZC3H12A Gene

Molecular function for ZC3H12A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Bifunctional enzyme with both endoribonuclease and deubiquitinase activities involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:26320658, PubMed:26134560, PubMed:22561375). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Functions as a deubiquitinase that affects the overall ubiquitination of cellular proteins (By similarity). Possesses deubiquitinase activity that specifically cleaves Lys-48- and Lys-63-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulates macrophage-mediated inflammatory response and immune homeostasis (By similarity). Deubiquitinates also the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation, which may be dependent on its deubiquitinase activity (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state, depending on both endoribonuclease and deubiquitinase activities (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs (PubMed:23355615). Binds to Japanese encephalitis virus (JEV) and dengue virus (DEN) RNAs (PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species (PubMed:24191027).
UniProtKB/Swiss-Prot Induction:
Up-regulated by the transcription factor ELK1 in a interleukin IL1B-dependent manner through activation of the NF-kappa-B and ERK signaling pathways (PubMed:19747262, PubMed:20137095, PubMed:22037600). Up-regulated by chemokine CCL2 in endothelial cells and in peripheral blood monocytes (PubMed:16574901, PubMed:18364357). Up-regulated in activated T lymphocytes (PubMed:23185455). Up-regulated by phorbol 12-myristate 13-acetate (PMA) in primary T lymphocytes (PubMed:19909337, PubMed:23185455). Up-regulated by interleukin IL17 in keratinocytes (PubMed:26320658). Up-regulated by lipopolysaccharide (LPS) (PubMed:19909337). Up-regulated by tumor necrosis factor TNF-alpha and interleukin IL1 in acute monocytic leukemia cell line THP-1 cells (PubMed:18178554, PubMed:19909337). Up-regulated by amyloid precursor protein (APP) (PubMed:19185603).
UniProtKB/Swiss-Prot Induction:
(Microbial infection) Up-regulated in response to Japanese encephalitis virus (JEV) and dengue virus (DEN) infections (PubMed:23355615).

Gene Ontology (GO) - Molecular Function for ZC3H12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0004540 ribonuclease activity IDA 23355615
GO:0035198 miRNA binding IDA 22055188
genes like me logo Genes that share ontologies with ZC3H12A: view
genes like me logo Genes that share phenotypes with ZC3H12A: view

Animal Models for ZC3H12A Gene

MGI Knock Outs for ZC3H12A:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZC3H12A Gene

Localization for ZC3H12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H12A Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Rough endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule. Note=Predominantly localized in the cytoplasm. Colocalizes with GW182 on many granule-like structures, probably corresponding to cytoplasmic GW bodies (GWBs), also called processing bodies (P bodies). Colocalizes with calnexin on the surface of the rough endoplasmic reticulum (RER) membrane and with translationally active polysomes (By similarity). Colocalizes with ZC3H12D in cytoplasmic mRNA processing P-body, also known as GW bodies (GWBs) (PubMed:22055188, PubMed:26134560). {ECO:0000269 PubMed:22055188, ECO:0000269 PubMed:26134560}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H12A Gene COMPARTMENTS Subcellular localization image for ZC3H12A gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
nucleus 5
plasma membrane 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZC3H12A Gene

Pathways & Interactions for ZC3H12A Gene

SuperPathways for ZC3H12A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay ISS --
GO:0001525 angiogenesis IEA --
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0002230 positive regulation of defense response to virus by host IDA 23355615
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZC3H12A: view

No data available for Pathways by source and SIGNOR curated interactions for ZC3H12A Gene

Drugs & Compounds for ZC3H12A Gene

No Compound Related Data Available

Transcripts for ZC3H12A Gene

Unigene Clusters for ZC3H12A Gene

Zinc finger CCCH-type containing 12A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for ZC3H12A Gene

GeneLoc Exon Structure for
ZC3H12A
ECgene alternative splicing isoforms for
ZC3H12A

Expression for ZC3H12A Gene

mRNA expression in normal human tissues for ZC3H12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZC3H12A Gene

This gene is overexpressed in Whole Blood (x5.3) and Skin - Not Sun Exposed (Suprapubic) (x4.0).

Protein differential expression in normal tissues from HIPED for ZC3H12A Gene

This gene is overexpressed in Pancreatic juice (35.7), Blymphocyte (16.0), Peripheral blood mononuclear cells (10.1), and CD8 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZC3H12A Gene



SOURCE GeneReport for Unigene cluster for ZC3H12A Gene Hs.656294

mRNA Expression by UniProt/SwissProt for ZC3H12A Gene

Q5D1E8-ZC12A_HUMAN
Tissue specificity: Expressed in heart, placenta, spleen, kidney, liver and lung (PubMed:19909337). Expressed in leukocytes (PubMed:19909337). Expressed in monocyte (PubMed:16574901).
genes like me logo Genes that share expression patterns with ZC3H12A: view

Protein tissue co-expression partners for ZC3H12A Gene

- Elite partner

Primer Products

Orthologs for ZC3H12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H12A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZC3H12A 35
  • 85.53 (n)
  • 86.79 (a)
ZC3H12A 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H12A 35
  • 82.75 (n)
  • 83.16 (a)
ZC3H12A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc3h12a 35
  • 81.15 (n)
  • 82.55 (a)
Zc3h12a 16
Zc3h12a 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZC3H12A 35
  • 98.78 (n)
  • 98.5 (a)
ZC3H12A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3h12a 35
  • 81.99 (n)
  • 82.89 (a)
oppossum
(Monodelphis domestica)
Mammalia ZC3H12A 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H12A 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H12A 35
  • 64.71 (n)
  • 64.22 (a)
ZC3H12A 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC3H12A 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498589 35
  • 63.93 (n)
  • 69.49 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC798235 35
  • 53.17 (n)
  • 51.94 (a)
zc3h12a 36
  • 50 (a)
OneToMany
ZC3H12A (2 of 2) 36
  • 46 (a)
OneToMany
Species with no ortholog for ZC3H12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H12A Gene

ENSEMBL:
Gene Tree for ZC3H12A (if available)
TreeFam:
Gene Tree for ZC3H12A (if available)

Paralogs for ZC3H12A Gene

Paralogs for ZC3H12A Gene

(3) SIMAP similar genes for ZC3H12A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZC3H12A Gene

genes like me logo Genes that share paralogs with ZC3H12A: view

Variants for ZC3H12A Gene

Sequence variations from dbSNP and Humsavar for ZC3H12A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17849897 - 37,483,451(+) GGCAG(A/G)CAGCC downstream-variant-500B, reference, missense
rs16824179 - 37,481,735(+) GGATC(A/G)TGGTT upstream-variant-2KB, reference, missense
rs9136 -- 37,484,302(+) GTAAA(C/T)TTTAA utr-variant-3-prime
rs215204 -- 37,478,011(+) TAGTT(C/G)CCAGT intron-variant, utr-variant-5-prime
rs215205 -- 37,482,611(+) GTGCC(C/G)TGTTT intron-variant, downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZC3H12A Gene

Variant ID Type Subtype PubMed ID
nsv483134 CNV Loss 15286789

Variation tolerance for ZC3H12A Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H12A Gene

HapMap Linkage Disequilibrium report
ZC3H12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H12A Gene

Disorders for ZC3H12A Gene

UniProtKB/Swiss-Prot

ZC12A_HUMAN
  • Note=Increased expression of ZC3H12A is associated with ischemic heart disease (PubMed:16574901). {ECO:0000269 PubMed:16574901}.

Relevant External Links for ZC3H12A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H12A

No disorders were found for ZC3H12A Gene.

No data available for MalaCards and Genatlas for ZC3H12A Gene

Publications for ZC3H12A Gene

  1. MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. (PMID: 22055188) Suzuki H.I. … Miyazono K. (Mol. Cell 2011) 2 3 4 67
  2. Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase. (PMID: 19747262) Skalniak L. … Jura J. (FEBS J. 2009) 3 23
  3. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PMID: 18178554) Liang J. … Fu M. (J. Biol. Chem. 2008) 2 3
  4. RGS2 suppresses breast cancer cell growth via a MCPIP1-dependent pathway. (PMID: 25187114) Lyu J.H. … Baek S.H. (J. Cell. Biochem. 2015) 3
  5. Emerging Roles of CCCH-Type Zinc Finger Proteins in Destabilizing mRNA Encoding Inflammatory Factors and Regulating Immune Responses. (PMID: 25955820) Yang C. … Gu Y. (Crit. Rev. Eukaryot. Gene Expr. 2015) 3

Products for ZC3H12A Gene

Sources for ZC3H12A Gene

Content