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Aliases for ZC3H12A Gene

Aliases for ZC3H12A Gene

  • Zinc Finger CCCH-Type Containing 12A 2 3
  • MCPIP1 3 4 6
  • MCPIP 3 4 6
  • Zinc Finger CCCH Domain-Containing Protein 12A 3 4
  • MCP Induced Protein 1 2 3
  • MCP-Induced Protein 1 3 4
  • MCP-1 Treatment-Induced Protein 3
  • Ribonuclease ZC3H12A 3
  • DJ423B22.1 3
  • EC 3.1.-.- 4

External Ids for ZC3H12A Gene

Previous GeneCards Identifiers for ZC3H12A Gene

  • GC01P037611
  • GC01P037712
  • GC01P037940
  • GC01P036058

Summaries for ZC3H12A Gene

Entrez Gene Summary for ZC3H12A Gene

  • ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]

GeneCards Summary for ZC3H12A Gene

ZC3H12A (Zinc Finger CCCH-Type Containing 12A) is a Protein Coding gene. GO annotations related to this gene include endonuclease activity. An important paralog of this gene is N4BP1.

UniProtKB/Swiss-Prot for ZC3H12A Gene

  • Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H12A Gene

Genomics for ZC3H12A Gene

Regulatory Elements for ZC3H12A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZC3H12A Gene

Start:
37,474,518 bp from pter
End:
37,484,379 bp from pter
Size:
9,862 bases
Orientation:
Plus strand

Genomic View for ZC3H12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZC3H12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H12A Gene

Proteins for ZC3H12A Gene

  • Protein details for ZC3H12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5D1E8-ZC12A_HUMAN
    Recommended name:
    Ribonuclease ZC3H12A
    Protein Accession:
    Q5D1E8
    Secondary Accessions:
    • D3DPT0
    • Q6I9Z1
    • Q9H5P1

    Protein attributes for ZC3H12A Gene

    Size:
    599 amino acids
    Molecular mass:
    65699 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Increased expression of ZC3H12A is associated with ischemic heart disease

    Three dimensional structures from OCA and Proteopedia for ZC3H12A Gene

neXtProt entry for ZC3H12A Gene

Proteomics data for ZC3H12A Gene at MOPED

Post-translational modifications for ZC3H12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC3H12A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZC3H12A

No data available for DME Specific Peptides for ZC3H12A Gene

Domains for ZC3H12A Gene

Gene Families for ZC3H12A Gene

HGNC:
  • ZC3H :Zinc fingers, CCCH-type domain containing

Protein Domains for ZC3H12A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC3H12A Gene

Graphical View of Domain Structure for InterPro Entry

Q5D1E8

UniProtKB/Swiss-Prot:

ZC12A_HUMAN :
  • Q5D1E8
Family:
  • Belongs to the ZC3H12 family.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with ZC3H12A: view

Function for ZC3H12A Gene

Molecular function for ZC3H12A Gene

UniProtKB/Swiss-Prot Function:
Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.
UniProtKB/Swiss-Prot Induction:
By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells.

Enzyme Numbers (IUBMB) for ZC3H12A Gene

Gene Ontology (GO) - Molecular Function for ZC3H12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H12A: view
genes like me logo Genes that share phenotypes with ZC3H12A: view

Animal Models for ZC3H12A Gene

MGI Knock Outs for ZC3H12A:

Animal Model Products

CRISPR Products

miRNA for ZC3H12A Gene

miRTarBase miRNAs that target ZC3H12A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC3H12A

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ZC3H12A Gene

Localization for ZC3H12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZC3H12A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H12A Gene COMPARTMENTS Subcellular localization image for ZC3H12A gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for ZC3H12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ZC3H12A: view

Pathways for ZC3H12A Gene

SuperPathways for ZC3H12A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006915 apoptotic process IEA --
GO:0010508 positive regulation of autophagy IDA 22739135
GO:0010628 positive regulation of gene expression IDA 22739135
GO:0010629 negative regulation of gene expression IDA 18178554
genes like me logo Genes that share ontologies with ZC3H12A: view

No data available for Pathways by source for ZC3H12A Gene

Transcripts for ZC3H12A Gene

Unigene Clusters for ZC3H12A Gene

Zinc finger CCCH-type containing 12A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC3H12A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for ZC3H12A Gene

GeneLoc Exon Structure for
ZC3H12A
ECgene alternative splicing isoforms for
ZC3H12A

Expression for ZC3H12A Gene

mRNA expression in normal human tissues for ZC3H12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZC3H12A Gene

This gene is overexpressed in Whole Blood (5.3) and Skin - Not Sun Exposed (Suprapubic) (4.0).

Protein differential expression in normal tissues for ZC3H12A Gene

This gene is overexpressed in Pancreatic juice (35.7), Blymphocyte (16.0), Peripheral blood mononuclear cells (10.1), and CD8 Tcells (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZC3H12A Gene

SOURCE GeneReport for Unigene cluster for ZC3H12A Gene Hs.656294

genes like me logo Genes that share expressions with ZC3H12A: view

Expression partners for ZC3H12A Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZC3H12A Gene

Orthologs for ZC3H12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H12A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZC3H12A 35
  • 85.53 (n)
  • 86.79 (a)
ZC3H12A 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZC3H12A 35
  • 82.75 (n)
  • 83.16 (a)
ZC3H12A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc3h12a 35
  • 81.15 (n)
  • 82.55 (a)
Zc3h12a 16
Zc3h12a 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZC3H12A 35
  • 98.78 (n)
  • 98.5 (a)
ZC3H12A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3h12a 35
  • 81.99 (n)
  • 82.89 (a)
oppossum
(Monodelphis domestica)
Mammalia ZC3H12A 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H12A 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZC3H12A 35
  • 64.71 (n)
  • 64.22 (a)
ZC3H12A 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC3H12A 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498589 35
  • 63.93 (n)
  • 69.49 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC798235 35
  • 53.17 (n)
  • 51.94 (a)
zc3h12a 36
  • 50 (a)
OneToMany
ZC3H12A (2 of 2) 36
  • 46 (a)
OneToMany
Species with no ortholog for ZC3H12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H12A Gene

ENSEMBL:
Gene Tree for ZC3H12A (if available)
TreeFam:
Gene Tree for ZC3H12A (if available)

Paralogs for ZC3H12A Gene

Paralogs for ZC3H12A Gene

Selected SIMAP similar genes for ZC3H12A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZC3H12A Gene

genes like me logo Genes that share paralogs with ZC3H12A: view

Variants for ZC3H12A Gene

Sequence variations from dbSNP and Humsavar for ZC3H12A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9136 -- 37,484,302(+) GTAAA(C/T)TTTAA utr-variant-3-prime
rs215204 -- 37,478,011(+) TAGTT(C/G)CCAGT intron-variant, upstream-variant-2KB
rs215205 -- 37,482,611(+) GTGCC(C/G)TGTTT intron-variant, reference, missense, downstream-variant-500B
rs1052225 -- 37,483,867(+) AGTTT(A/C)AGGAG utr-variant-3-prime
rs1052282 -- 37,484,152(+) ACCTT(C/T)TGCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZC3H12A Gene

Variant ID Type Subtype PubMed ID
nsv483134 CNV Loss 15286789

Relevant External Links for ZC3H12A Gene

HapMap Linkage Disequilibrium report
ZC3H12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H12A Gene

Disorders for ZC3H12A Gene

No disorders were found for ZC3H12A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZC3H12A Gene

Publications for ZC3H12A Gene

  1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. (PMID: 18178554) Liang J. … Fu M. (J. Biol. Chem. 2008) 2 3 4
  2. Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP). (PMID: 18364357) Niu J. … Kolattukudy P.E. (J. Biol. Chem. 2008) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase. (PMID: 19747262) Skalniak L. … Jura J. (FEBS J. 2009) 3 23
  5. Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. (PMID: 16574901) Zhou L. … Kolattukudy P.E. (Circ. Res. 2006) 3 4

Products for ZC3H12A Gene

Sources for ZC3H12A Gene

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