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Aliases & Descriptions for ZC3H12A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.1.-.- 3 | | FLJ23231 1, 2 | | MCPIP 2, 3 | | MCPIP1 1, 2, 3 | | OTTHUMP00000004398 2 | | OTTHUMP00000004399 2 | | RP3-423B22.1 2 | | dJ423B22.1 2 |
| | | Descriptions |
|---|
| MCP induced protein 1 2 | | MCP-1 treatment-induced protein 2 | | MCP-induced protein 1 2, 3 | | Zinc finger CCCH domain-containing protein 12A 3 | | zinc finger CCCH-type containing 12A 2 |
|
| | Search outside databases for aliases for ZC3H12A genePrevious GC identifer: GC01P037611 |
Summaries for ZC3H12A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ZC3H12A: ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM] UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8Function: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19 |
Genomic Location for ZC3H12A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ZC3H12A gene 
Entrez Gene cytogenetic band: 1p34.3 Ensembl cytogenetic band: 1p34.3 HGNC cytogenetic band: 1p34.3ZC3H12A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P037712:
(about GC identifiers)
Start:
|
37,712,706 bp from pter |
End:
|
37,722,565 bp from pter |
Size:
|
9,860 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for ZC3H12A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8 (See
protein sequence)Recommended Name: Ribonuclease ZC3H12A Size: 599 amino acids; 65699 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus
Miscellaneous: Increased expression of ZC3H12A is associated with ischemic heart disease
Caution: Was originally (PubMed:18364357) proposed to bind to DNA and act as transcription factor
Secondary accessions: Q6I9Z1 Q9H5P1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_079355.2
ENSEMBL proteins: ENSP00000362174 ENSP00000362179
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for ZC3H12A: Assays for ZC3H12A: | Protein
Domains/ Families for ZC3H12A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5D1E8 UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8Similarity: Belongs to the ZC3H12 familySimilarity: Contains 1 C3H1-type zinc finger | Gene Function for ZC3H12A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025079
Applied Biosystems Silencer® siRNAs for ZC3H12A
Sigma-Aldrich siRNA for ZC3H12A  Sigma-Aldrich shRNA for ZC3H12A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_025079                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_025079                                  untagged cDNA clone in CMV expression vector: NM_025079 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_025079
UniProtKB/Swiss-Prot: ZC12A_HUMAN, Q5D1E8Function: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19Induction: By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cellsEnzyme Number (IUBMB): EC 3.1.-.- 5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Zc3h12a):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- | About this table | Pathways & Interactions for ZC3H12A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Interacting proteins for ZC3H12A (ENSP000003621743) via UniProtKB, MINT, and/or STRINGAbout this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for ZC3H12A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ZC3H12A
|
Transcripts for ZC3H12A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025079
Sigma-Aldrich siRNA for ZC3H12A  Sigma-Aldrich shRNA for ZC3H12A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_025079 REFSEQ mRNAs for ZC3H12A gene: NM_025079.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_025079               OriGene GFP tagged cDNA clone in CMV expression vector: NM_025079                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_025079                                  untagged cDNA clone in CMV expression vector: NM_025079  Additional cDNA sequence: AK026884.1 AK093343.1 AY920403.1 BC005001.1 CR457364.1 FJ695517.1 9 DOTS entries: DT.451660 DT.100783966 DT.92026405 DT.121360856 DT.86845883 DT.91701293 DT.95355975 DT.95364524 DT.99967911 24/120 AceView cDNA sequences (see all 120
):AI538369 AA909913 AI160574 AA922836 BQ927247 BX953361 AL710798 AW130116 BM980772 CD722510 BU540574 CB126802 BC005001 AU280264 BQ691835 AI631181 AA640102 AW138503 AI082816 CB131278 AW104766 AK026884 AL602376 AI818610
highest scoring ESTs for ZC3H12A:AA011633 AA004289 AA004335 AA011632 AA292423 AA477110 AA477355 AA640102 AA669468 AA858323 Unigene Cluster for ZC3H12A: Zinc finger CCCH-type containing 12A Hs.656294 [show with all ESTs]Unigene Representative Sequence: NM_025079
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H12A
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ZC3H12A
2 Ensembl transcripts including schematic representations: ENST00000373082
ENST00000373087
|
Expression for ZC3H12A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZC3H12A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H12A
1 / 2 / 3 3 probe-sets matching ZC3H12A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.656294
|
Orthologs for ZC3H12A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZC3H12A gene from 5/7 species (see all 7
)
About this table Species with no ortholog for ZC3H12A
ENSEMBL Gene Tree for ZC3H12A | Paralogs for ZC3H12A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ZC3H12A gene
- ZC3H12C2 ZC3H12B2 ZC3H12D2
|
SNPs/Variants for ZC3H12A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ZC3H12A (up to first 250kb)
|
Disorders & Mutations for ZC3H12A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610562
|
Medical News for ZC3H12A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ZC3H12A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for ZC3H12A gene (see all 12
): |
Search for ZC3H12A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZC3H12A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZC3H12A
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZC3H12A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ZC3H12A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ZC3H12A:

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Incremental update: 13 Oct 2009
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