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Aliases for ZC3H11A Gene

Aliases for ZC3H11A Gene

  • Zinc Finger CCCH-Type Containing 11A 2 3 5
  • Zinc Finger CCCH-Type Domain Containing 11A 2 3
  • ZC3HDC11A 3 4
  • EC 4.2.1.11 63
  • EC 4.1.1.31 63
  • KIAA0663 4

External Ids for ZC3H11A Gene

Previous HGNC Symbols for ZC3H11A Gene

  • ZC3HDC11A

Previous GeneCards Identifiers for ZC3H11A Gene

  • GC01P200497
  • GC01P202031
  • GC01P203765
  • GC01P174930

Summaries for ZC3H11A Gene

GeneCards Summary for ZC3H11A Gene

ZC3H11A (Zinc Finger CCCH-Type Containing 11A) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ZC3H11A Gene

  • Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.

Gene Wiki entry for ZC3H11A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H11A Gene

Genomics for ZC3H11A Gene

Regulatory Elements for ZC3H11A Gene

Promoters for ZC3H11A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZC3H11A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC3H11A Gene

Chromosome:
1
Start:
203,795,537 bp from pter
End:
203,854,128 bp from pter
Size:
58,592 bases
Orientation:
Plus strand

Genomic View for ZC3H11A Gene

Genes around ZC3H11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC3H11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC3H11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H11A Gene

Proteins for ZC3H11A Gene

  • Protein details for ZC3H11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75152-ZC11A_HUMAN
    Recommended name:
    Zinc finger CCCH domain-containing protein 11A
    Protein Accession:
    O75152
    Secondary Accessions:
    • Q6AHY4
    • Q6AHY9
    • Q6AW79
    • Q6AWA1
    • Q6PJK4
    • Q86XZ7

    Protein attributes for ZC3H11A Gene

    Size:
    810 amino acids
    Molecular mass:
    89131 Da
    Quaternary structure:
    • Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex.
    SequenceCaution:
    • Sequence=BAA31638.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH10553.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZC3H11A Gene

Proteomics data for ZC3H11A Gene at MOPED

Selected DME Specific Peptides for ZC3H11A Gene

Post-translational modifications for ZC3H11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZC3H11A

Domains & Families for ZC3H11A Gene

Gene Families for ZC3H11A Gene

Protein Domains for ZC3H11A Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75152

UniProtKB/Swiss-Prot:

ZC11A_HUMAN :
  • Contains 3 C3H1-type zinc fingers.
Similarity:
  • Contains 3 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZC3H11A: view

Function for ZC3H11A Gene

Molecular function for ZC3H11A Gene

UniProtKB/Swiss-Prot Function:
Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.

Enzyme Numbers (IUBMB) for ZC3H11A Gene

Phenotypes for ZC3H11A Gene

genes like me logo Genes that share phenotypes with ZC3H11A: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC3H11A Gene

Localization for ZC3H11A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC3H11A Gene COMPARTMENTS Subcellular localization image for ZC3H11A gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZC3H11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZC3H11A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZC3H11A Gene

Pathways & Interactions for ZC3H11A Gene

genes like me logo Genes that share pathways with ZC3H11A: view

Gene Ontology (GO) - Biological Process for ZC3H11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with ZC3H11A: view

No data available for SIGNOR curated interactions for ZC3H11A Gene

Drugs & Compounds for ZC3H11A Gene

No Compound Related Data Available

Transcripts for ZC3H11A Gene

Unigene Clusters for ZC3H11A Gene

Zinc finger CCCH-type containing 11A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H11A Gene

No ASD Table

Relevant External Links for ZC3H11A Gene

GeneLoc Exon Structure for
ZC3H11A
ECgene alternative splicing isoforms for
ZC3H11A

Expression for ZC3H11A Gene

mRNA expression in normal human tissues for ZC3H11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZC3H11A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.5), Testis (11.0), and CD8 Tcells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3H11A Gene



SOURCE GeneReport for Unigene cluster for ZC3H11A Gene Hs.532399

genes like me logo Genes that share expression patterns with ZC3H11A: view

Protein tissue co-expression partners for ZC3H11A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H11A Gene

Orthologs for ZC3H11A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC3H11A 35
  • 99.84 (n)
  • 99.75 (a)
ZC3H11A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZC3H11A 36
  • 83 (a)
OneToOne
ZC3H11A 35
  • 89.51 (n)
  • 86.79 (a)
dog
(Canis familiaris)
Mammalia ZC3H11A 35
  • 90.4 (n)
  • 89.37 (a)
ZC3H11A 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc3h11a 16
Zc3h11a 35
  • 83.06 (n)
  • 81.27 (a)
Zc3h11a 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZC3H11A 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC3H11A 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc3h11a 35
  • 82.04 (n)
  • 80.64 (a)
chicken
(Gallus gallus)
Aves ZC3H11A 36
  • 61 (a)
OneToOne
ZC3H11A 35
  • 64.94 (n)
  • 62.66 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.6811 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17290 35
zc3h11a 35
  • 57.38 (n)
  • 50.62 (a)
zebrafish
(Danio rerio)
Actinopterygii zc3h11a 36
  • 39 (a)
OneToOne
wufc32e10 35
zc3h11a 35
  • 52.36 (n)
  • 46.69 (a)
Species with no ortholog for ZC3H11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H11A Gene

ENSEMBL:
Gene Tree for ZC3H11A (if available)
TreeFam:
Gene Tree for ZC3H11A (if available)

Paralogs for ZC3H11A Gene

(1) SIMAP similar genes for ZC3H11A Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZC3H11A Gene

genes like me logo Genes that share paralogs with ZC3H11A: view

No data available for Paralogs for ZC3H11A Gene

Variants for ZC3H11A Gene

Sequence variations from dbSNP and Humsavar for ZC3H11A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2050698 -- 203,844,148(+) cactg(C/T)gcccg intron-variant
rs2225931 -- 203,822,488(-) TCAGC(A/T)CAAAG intron-variant
rs2275325 -- 203,831,607(+) ACTTG(C/G)GATAG intron-variant
rs2365868 -- 203,807,497(+) ATGTG(A/G)CACAA intron-variant
rs2365979 -- 203,822,581(+) TTCCT(A/C)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC3H11A Gene

Variant ID Type Subtype PubMed ID
nsv873111 CNV Gain 21882294
nsv520482 CNV Loss 19592680
nsv522989 CNV Loss 19592680
esv2658459 CNV Deletion 23128226
esv2678729 CNV Deletion 23128226
esv1633923 CNV Insertion 17803354

Variation tolerance for ZC3H11A Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC3H11A Gene

HapMap Linkage Disequilibrium report
ZC3H11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H11A Gene

Disorders for ZC3H11A Gene

Relevant External Links for ZC3H11A

Genetic Association Database (GAD)
ZC3H11A
Human Genome Epidemiology (HuGE) Navigator
ZC3H11A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC3H11A

No disorders were found for ZC3H11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC3H11A Gene

Publications for ZC3H11A Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S. … Ghosh M.K. (Cell Oncol (Dordr) 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for ZC3H11A Gene

Sources for ZC3H11A Gene

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