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ZC3H11A Gene

protein-coding GIFtS: 54

GC01P202031

zinc finger CCCH-type containing 11A
(Previous name: zinc finger CCCH-type domain containing 11A )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZC3HDC11A)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp686D03108 ^²
DKFZp686F14109 ^²
DKFZp781G2455 ^²
KIAA0663 ^¹, ², ³
OTTHUMP00000034097 ^²
OTTHUMP00000034213 ^²
OTTHUMP00000034214 ^²
OTTHUMP00000034215 ^²
ZC3HDC11A ^², ³

Descriptions
zinc finger CCCH-type containing 11A ^²
zinc finger CCCH-type domain containing 11A ^¹, ²

External Ids
HGNC: 29093¹
Entrez Gene: 9877²
UniProtKB: O75152³
Ensembl: ENSG00000058673⁷

Search outside databases for aliases for ZC3H11A gene

Previous GC identifer: GC01P200497

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for ZC3H11A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZC3H11A gene

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

ZC3H11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P202031: (about GC identifiers)

Start:	202,031,374 bp from pter
End:	202,089,879 bp from pter
Size:	58,506 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZC11A_HUMAN, O75152 (See protein sequence)

Recommended Name: Zinc finger CCCH domain-containing protein 11A

Size: 810 amino acids; 89131 Da

Sequence caution: Sequence=AAH48271.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.

Potential poly-A sequence; Sequence=CAH10553.1; Type=Miscellaneous discrepancy; Note=Contaminating

sequence. Potential poly-A sequence;

Secondary accessions: Q6AHY4 Q6AHY9 Q6AW79 Q6AWA1 Q6PJK4 Q86XZ7

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055642.3

ENSEMBL proteins:

ENSP00000356183 ENSP00000356181 ENSP00000333253 ENSP00000356179

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZC3H11A)
	Human Recombinant Proteins from Abnova (ZC3H11A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ZC3H11A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZC3H11A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZC3H11A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZC3H11A)
	Novus Biologicals Antibodies for ZC3H11A

Assays for ZC3H11A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O75152

ProtoNet protein and cluster: O75152

1 Blocks protein family: IPB000571 Zn-finger

UniProtKB/Swiss-Prot: ZC11A_HUMAN, O75152

Similarity: Contains 3 C3H1-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H11A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZC3H11A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014827

Applied Biosystems Silencer® siRNAs for ZC3H11A

Sigma-Aldrich siRNA for ZC3H11A

Sigma-Aldrich shRNA for ZC3H11A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZC3H11A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014827
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014827
untagged cDNA clone in CMV expression vector: NM_014827

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014827

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for ZC3H11A (O75152²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
MLH1 P40692² MINT-67298
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZC3H11A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H11A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZC3H11A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014827

Sigma-Aldrich siRNA for ZC3H11A

Sigma-Aldrich shRNA for ZC3H11A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014827

REFSEQ mRNAs for ZC3H11A gene:

NM_014827.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014827

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014827
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014827
                                 untagged cDNA clone in CMV expression vector: NM_014827

Additional cDNA sequence:

AB014563.1 AK095858.1 AK296983.1 AK310470.1 AL049419.1 BC014268.2 BC038513.2 BC046137.2

BC048271.1 CR627439.1

24/50 DOTS entries (see all 50 ):

DT.319879 DT.99941762 DT.121452670 DT.100802807 DT.91757416 DT.95368226 DT.101984844 DT.92024926

DT.121452760 DT.319880 DT.95234065 DT.121452703 DT.100689774 DT.100825692 DT.121419632 DT.121419635

DT.121452692 DT.95234119 DT.121452745 DT.121452748 DT.91836429 DT.95156707 DT.95157215 DT.100825689

24/540 AceView cDNA sequences (see all 540 ):

AV705953 BQ011090 CA422664 CA415029 BM661734 AA767554 AA682981 AA774128

BX470522 BQ420270 AL041677 BM689769 BU615369 CK903115 AB014563 AA329745

AA569964 AI278786 BM972565 AL120732 CN478993 BU521292 AI193446 BM801763

highest scoring ESTs for ZC3H11A:

AB014563 AA001737 AA004205 AA007407 AA007422 AA011499 AA045835 AA114829 AA148861 AA165561

Unigene Cluster for ZC3H11A:

Zinc finger CCCH-type containing 11A

Hs.532399 [show with all ESTs]

Unigene Representative Sequence: CR627439

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000367214 ENST00000367212 ENST00000332127 ENST00000367210

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ZC3H11A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H11A

¹ / ² / ³

8 probe-sets matching ZC3H11A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41170_at²^{, 3}	U95-A	1	1.00	1.00	-0.12	1.25	AB014563	1.00	0.90	0.95	1
90299_at²^{, 3}	U95-E	4	1.00	0.48	0.87	0.76	AA993532	0.20	0.12	0.17	2
205788_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014827	0.60	1.00	0.82	1
205787_x_at²^{, 3}	U133-A	6	1.00	0.22	--	--	AI803216	0.40	0.67	0.55	1
227712_at²	U133-B	2	0.73	0.50	--	--	--	--	--	--	--
205788_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205787_x_at²	U133Plus2	6	1.00	0.22	--	--	--	--	--	--	--
227712_at²	U133Plus2	2	0.73	0.50	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATTTTCTAC

SOURCE GeneReport for Unigene cluster: Hs.532399
Expression variation in blood from EXPOLDB for ZC3H11A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZC3H11A gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZC3H11A¹	--	zinc finger CCCH-type containing 11A	90.4(n) 89.37(a)	478932 XM_536091.2 XP_536091.2
chimpanzee (Pan troglodytes)	ZC3H11A¹	--	zinc finger CCCH-type containing 11A	99.84(n) 99.75(a)	462805 XM_001157493.1 XP_001157493.1
rat (Rattus norvegicus)	RGD1308290¹	--	similar to RIKEN cDNA 5730454B08	82(n) 80.64(a)	360845 XM_001059869.1 XP_001059869.1
mouse (Mus musculus)	Zc3h11a^{1, 5}	1⁵	zinc finger CCCH type containing 11A^{1, 5}	83.06(n)¹ 81.27(a)¹	70579¹ NM_144530.5¹ NP_653113.4¹ AA117506⁵ AA267387⁵ (see all 39)
chicken (Gallus gallus)	RCJMB04_17l7¹	--	zinc finger CCCH-type containing 11A	65.55(n) 62.85(a)	421172 NM_001031030.1 NP_001026201.1

About this table Species with no ortholog for ZC3H11A

ENSEMBL Gene Tree for ZC3H11A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/406 NCBI SNPs in ZC3H11A are shown (see all 406 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 108)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4951008^1,2	A,C,F,H	202030330(+)	`attttT/Cagtgt`	1	--	ng5¹		7		EU EA WA NA	560
	rs4951005^1,2	A,C,F,H	202029948(+)	`TCTGTC/TGACAT`	1	--	ng5¹		11		EU EA WA NA	980
--	rs7311^1,2	A,C,F	202089689(+)	`AATCAC/GCTTAC`	1	--	ut3¹		1		MN	184
	rs1572655^1,2	A,C,F	202090325(+)	`TTTATG/AGAAGT`	1	--	ng3¹		4		EA NA	158
--	rs4951233^1,2	A,C,F	202029912(+)	`aaaaaT/GaaaTT`	1	--	ng5¹ trp³		3		NA	142
--	rs7555435^1,2	A,C	202052775(+)	`GAAGCA/CGTGGC`	1	--	ut5¹		0	--	--	--	--
--	rs12569219^1,2	F,H	202029613(+)	`ATTGGC/AAGTTG`	1	--	ng5¹		4		EU EA WA	420
--	rs6593948^1,2	A,C	202029485(+)	`gaggcA/Gggatt`	1	--	ng5¹		0	--	--	--	--
--	rs4951234^1,2	A,C	202030568(+)	`cccagA/Gttcaa`	1	--	ng5¹ tfbs³		0	--	--	--	--
	rs11240604^1,2	C,H	202085757(+)	`ACAGAC/ACTTGG`	1	N/T	mis¹ ese³		8		EU EA WA	836

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HapMap Linkage Disequilibrium images for ZC3H11A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/16 PubMed articles for ZC3H11A gene (see all 16 ):

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{2, 3, 4} Ishikawa K....Ohara O. (1998)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. (PubMed id 17287340)⁴ Molina H.... Pandey A. (2007)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)⁴ Matsuoka S.... Elledge S.J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9877	HGNC: 29093	AceView: KIAA0663	Ensembl:ENSG00000058673	euGenes: HUgn9877
ECgene: ZC3H11A	H-InvDB: ZC3H11A

(According to HUGE)
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HUGE: KIAA0663

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZC3H11A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ZC3H11A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZC3H11A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZC3H11A		Antibodies for ZC3H11A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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ZC3H11A Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for ZC3H11A

Summaries
for ZC3H11A

Genomic Location
for ZC3H11A

Proteins
for ZC3H11A

Protein Domains/
Families
for ZC3H11A

Gene Function
for ZC3H11A

Pathways & Interactions
for ZC3H11A

Drugs & Compounds
for ZC3H11A

Transcripts
for ZC3H11A

Expression
for ZC3H11A

Orthologs
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Paralogs
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SNPs/Variants
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Disorders & Mutations
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Medical News
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Publications
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Genome Databases showing ZC3H11A

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZC3H11A Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor ZC3H11A

Summariesfor ZC3H11A

Genomic Locationfor ZC3H11A

Proteinsfor ZC3H11A

Protein Domains/Familiesfor ZC3H11A

Gene Functionfor ZC3H11A

Pathways & Interactionsfor ZC3H11A

Drugs & Compoundsfor ZC3H11A

Transcriptsfor ZC3H11A

Expression for ZC3H11A

Orthologsfor ZC3H11A

Paralogsfor ZC3H11A

SNPs/Variantsfor ZC3H11A

Disorders & Mutationsfor ZC3H11A

Medical Newsfor ZC3H11A

Publicationsfor ZC3H11A

Search for ZC3H11A

Genome Databases showing ZC3H11A

Other Databases showing ZC3H11A

Specialized Databases showing ZC3H11A

Licensable Technologiesfor ZC3H11A

Servicesfor ZC3H11A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZC3H11A

Summaries
for ZC3H11A

Genomic Location
for ZC3H11A

Proteins
for ZC3H11A

Protein Domains/
Families
for ZC3H11A

Gene Function
for ZC3H11A

Pathways & Interactions
for ZC3H11A

Drugs & Compounds
for ZC3H11A

Transcripts
for ZC3H11A

Expression
for ZC3H11A

Orthologs
for ZC3H11A

Paralogs
for ZC3H11A

SNPs/Variants
for ZC3H11A

Disorders & Mutations
for ZC3H11A

Medical News
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Publications
for ZC3H11A

Licensable Technologies
for ZC3H11A

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