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Aliases for ZC3H11A Gene

Aliases for ZC3H11A Gene

  • Zinc Finger CCCH-Type Containing 11A 2 3
  • Zinc Finger CCCH-Type Domain Containing 11A 2 3
  • ZC3HDC11A 3 4
  • KIAA0663 4 6
  • Zinc Finger CCCH Domain-Containing Protein 11A 3
  • EC 63
  • EC 63

External Ids for ZC3H11A Gene

Previous HGNC Symbols for ZC3H11A Gene

  • ZC3HDC11A

Previous GeneCards Identifiers for ZC3H11A Gene

  • GC01P200497
  • GC01P202031
  • GC01P203765
  • GC01P174930

Summaries for ZC3H11A Gene

GeneCards Summary for ZC3H11A Gene

ZC3H11A (Zinc Finger CCCH-Type Containing 11A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZC3H11A Gene

  • Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.

Gene Wiki entry for ZC3H11A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC3H11A Gene

Genomics for ZC3H11A Gene

Regulatory Elements for ZC3H11A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZC3H11A Gene

203,795,537 bp from pter
203,854,128 bp from pter
58,592 bases
Plus strand

Genomic View for ZC3H11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZC3H11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC3H11A Gene

Proteins for ZC3H11A Gene

  • Protein details for ZC3H11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger CCCH domain-containing protein 11A
    Protein Accession:
    Secondary Accessions:
    • Q6AHY4
    • Q6AHY9
    • Q6AW79
    • Q6AWA1
    • Q6PJK4
    • Q86XZ7

    Protein attributes for ZC3H11A Gene

    810 amino acids
    Molecular mass:
    89131 Da
    Quaternary structure:
    • Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex.
    • Sequence=BAA31638.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH10553.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZC3H11A Gene

Proteomics data for ZC3H11A Gene at MOPED

Selected DME Specific Peptides for ZC3H11A Gene

Post-translational modifications for ZC3H11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZC3H11A

Domains for ZC3H11A Gene

Gene Families for ZC3H11A Gene

  • ZC3H :Zinc fingers, CCCH-type domain containing

Protein Domains for ZC3H11A Gene


Graphical View of Domain Structure for InterPro Entry



  • O75152
  • Contains 3 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZC3H11A: view

Function for ZC3H11A Gene

Molecular function for ZC3H11A Gene

UniProtKB/Swiss-Prot Function:
Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.

Enzyme Numbers (IUBMB) for ZC3H11A Gene

Gene Ontology (GO) - Molecular Function for ZC3H11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC3H11A: view

Animal Model Products

CRISPR Products

miRNA for ZC3H11A Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC3H11A

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZC3H11A Gene

Localization for ZC3H11A Gene

Subcellular locations from

Jensen Localization Image for ZC3H11A Gene COMPARTMENTS Subcellular localization image for ZC3H11A gene
Compartment Confidence
cytoskeleton 3
nucleus 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZC3H11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 colocalizes_with transcription export complex IDA 22928037
genes like me logo Genes that share ontologies with ZC3H11A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZC3H11A Gene

Pathways for ZC3H11A Gene

SuperPathways for ZC3H11A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC3H11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016973 poly(A)+ mRNA export from nucleus IMP 22928037
genes like me logo Genes that share ontologies with ZC3H11A: view

No data available for Pathways by source for ZC3H11A Gene

Transcripts for ZC3H11A Gene

Unigene Clusters for ZC3H11A Gene

Zinc finger CCCH-type containing 11A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZC3H11A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H11A Gene

No ASD Table

Relevant External Links for ZC3H11A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC3H11A Gene

mRNA expression in normal human tissues for ZC3H11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZC3H11A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.5), Testis (11.0), and CD8 Tcells (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC3H11A Gene

SOURCE GeneReport for Unigene cluster for ZC3H11A Gene Hs.532399

genes like me logo Genes that share expressions with ZC3H11A: view

Expression partners for ZC3H11A Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC3H11A Gene

Orthologs for ZC3H11A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZC3H11A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZC3H11A 35
  • 89.51 (n)
  • 86.79 (a)
ZC3H11A 36
  • 83 (a)
(Canis familiaris)
Mammalia ZC3H11A 35
  • 90.4 (n)
  • 89.37 (a)
ZC3H11A 36
  • 88 (a)
(Mus musculus)
Mammalia Zc3h11a 35
  • 83.06 (n)
  • 81.27 (a)
Zc3h11a 16
Zc3h11a 36
  • 81 (a)
(Pan troglodytes)
Mammalia ZC3H11A 35
  • 99.84 (n)
  • 99.75 (a)
ZC3H11A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zc3h11a 35
  • 82.04 (n)
  • 80.64 (a)
(Monodelphis domestica)
Mammalia ZC3H11A 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ZC3H11A 36
  • 67 (a)
(Gallus gallus)
Aves ZC3H11A 35
  • 64.94 (n)
  • 62.66 (a)
ZC3H11A 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
-- 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17290 35
zc3h11a 35
  • 57.38 (n)
  • 50.62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6811 35
(Danio rerio)
Actinopterygii wufc32e10 35
zc3h11a 35
  • 52.36 (n)
  • 46.69 (a)
zc3h11a 36
  • 39 (a)
Species with no ortholog for ZC3H11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC3H11A Gene

Gene Tree for ZC3H11A (if available)
Gene Tree for ZC3H11A (if available)

Paralogs for ZC3H11A Gene

Selected SIMAP similar genes for ZC3H11A Gene using alignment to 5 proteins: Pseudogenes for ZC3H11A Gene

genes like me logo Genes that share paralogs with ZC3H11A: view

No data available for Paralogs for ZC3H11A Gene

Variants for ZC3H11A Gene

Sequence variations from dbSNP and Humsavar for ZC3H11A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7311 -- 203,853,938(+) AATCA(C/G)CTTAC utr-variant-3-prime
rs7312 -- 203,854,093(+) TTGTT(A/T)GTGTT utr-variant-3-prime
rs1572655 -- 203,854,574(+) TTTAT(A/G)GAAGT downstream-variant-500B
rs1801839 -- 203,849,892(+) TGTGC(A/C/G)AGGAA missense, reference
rs1801840 -- 203,853,311(+) CCTGA(G/T)GGAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZC3H11A Gene

Variant ID Type Subtype PubMed ID
nsv873111 CNV Gain 21882294
nsv520482 CNV Loss 19592680
nsv522989 CNV Loss 19592680
esv2658459 CNV Deletion 23128226
esv2678729 CNV Deletion 23128226
esv1633923 CNV Insertion 17803354

Relevant External Links for ZC3H11A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC3H11A Gene

Disorders for ZC3H11A Gene

Relevant External Links for ZC3H11A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ZC3H11A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZC3H11A Gene

Publications for ZC3H11A Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 48
  4. The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. (PMID: 22928037) Folco E.G. … Reed R. (PLoS ONE 2012) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for ZC3H11A Gene

Sources for ZC3H11A Gene

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