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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZC3H11A Gene

protein-coding   GIFtS: 53
GCID: GC01P203765

Zinc Finger CCCH-Type Containing 11A

(Previous name: zinc finger CCCH-type domain containing 11A)
(Previous symbol: ZC3HDC11A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger CCCH-Type Containing 11A1 2     Zinc Finger CCCH Domain-Containing Protein 11A2
ZC3HDC11A1 2 3     EC 4.1.1.318
Zinc Finger CCCH-Type Domain Containing 11A1 2     EC 4.2.1.118
KIAA06633 5     

External Ids:    HGNC: 290931   Entrez Gene: 98772   Ensembl: ENSG000000586737   OMIM: 6135135   UniProtKB: O751523   

Export aliases for ZC3H11A gene to outside databases

Previous GC identifers: GC01P200497 GC01P202031 GC01P174930


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZC3H11A Gene: 
ZC3H11A (zinc finger CCCH-type containing 11A) is a protein-coding gene. Diseases associated with ZC3H11A include myopia, and essential hypertension. GO annotations related to this gene include zinc ion binding and nucleic acid binding.

Gene Wiki entry for ZC3H11A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZC3H11A gene promoter:
         MEF-2   CUTL1   Cdc5   HNF-1A   AREB6   MEF-2A   HNF-1   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC3H11A promoter sequence
   Search SABiosciences Chromatin IP Primers for ZC3H11A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC3H11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

ZC3H11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3H11A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P203765:  view genomic region     (about GC identifiers)

Start:
203,764,751 bp from pter      End:
203,823,256 bp from pter
Size:
58,506 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZC11A_HUMAN, O75152 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 11A  
Size: 810 amino acids; 89131 Da
Sequence caution: Sequence=BAA31638.2; Type=Erroneous initiation; Sequence=CAH10553.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: Q6AHY4 Q6AHY9 Q6AW79 Q6AWA1 Q6PJK4 Q86XZ7

Explore the universe of human proteins at neXtProt for ZC3H11A: NX_O75152

Explore proteomics data for ZC3H11A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75152

  • 2 DME Specific Peptides for ZC3H11A (O75152)
     LTERLGK  AAQTLEK 

    ZC3H11A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZC3H11A Protein Expression
    REFSEQ proteins: NP_055642.3  
    ENSEMBL proteins: 
     ENSP00000406531   ENSP00000415072   ENSP00000356183   ENSP00000356181   ENSP00000333253  
     ENSP00000432602   ENSP00000356179   ENSP00000438527  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC3H: Zinc fingers, CCCH-type domain containing

    1 InterPro protein domain:
     IPR000571 Znf_CCCH

    Graphical View of Domain Structure for InterPro Entry O75152

    ProtoNet protein and cluster: O75152

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: ZC11A_HUMAN, O75152
    Similarity: Contains 3 C3H1-type zinc fingers


    ZC3H11A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Numbers (IUBMB): EC 4.1.1.312 EC 4.2.1.112

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZC3H11A for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3H11A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/37 Interacting proteins for ZC3H11A (O751521, 2, 3 ENSP000003332534) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406921, 2, 3, ENSP000002317904EBI-748480,EBI-744248 MINT-67298 I2D: score=5 STRING: ENSP00000231790
    SUMO1P631652, 3, ENSP000003760764MINT-8173832 I2D: score=1 STRING: ENSP00000376076
    BEND3Q5T5X72MINT-8173832
    CHAMP1Q96JM32MINT-8173832
    CTPS1P178122MINT-8173832
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZC3H11A (ZC11A)

    Search CenterWatch for drugs/clinical trials and news about ZC3H11A / ZC11A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZC3H11A gene: 
    NM_014827.4  

    Unigene Cluster for ZC3H11A:

    Zinc finger CCCH-type containing 11A
    Hs.532399  [show with all ESTs]
    Unigene Representative Sequence: CR627439
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466470 ENST00000432282 ENST00000453771 ENST00000461980 ENST00000367214
    ENST00000492823 ENST00000367212(uc001hag.1) ENST00000332127(uc001hac.3 uc001had.3 uc001hae.3 uc010pqm.2)
    ENST00000495527 ENST00000367210 ENST00000480354 ENST00000488411 ENST00000545588(uc001haf.3)

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    Additional mRNA sequence: 

    AB014563.1 AK095858.1 AK296983.1 AK310470.1 AL049419.1 BC014268.2 BC038513.2 BC046137.2 
    BC048271.1 CR627439.1 

    24/48 DOTS entries (see all 48):

    DT.319879  DT.99941762  DT.121452670  DT.100802807  DT.91757416  DT.95368226  DT.101984844  DT.92024926 
    DT.121452760  DT.95234065  DT.319880  DT.121452703  DT.100689774  DT.100825692  DT.121419632  DT.121419635 
    DT.121452692  DT.95234119  DT.121452745  DT.121452748  DT.95156707  DT.95157215  DT.121452693  DT.121452706 

    24/540 AceView cDNA sequences (see all 540):

    AA804853 AW295659 AF086224 BQ446621 BU521292 AI193446 BQ946141 BQ775379 
    BM801763 BX350111 AI570930 CN482515 CA422664 BQ011090 BU542936 BM973370 
    AA682981 BM661734 AW275031 AA329851 AA535623 CK903115 AA329745 AA774128 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZC3H11A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTTCTAC
    ZC3H11A Expression
    About this image


    See ZC3H11A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZC3H11A

    SOURCE GeneReport for Unigene cluster: Hs.532399
        SABiosciences Custom PCR Arrays for ZC3H11A
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZC3H11A gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc3h11a1 , 5 zinc finger CCCH type containing 11A1, 5 83.06(n)1
    81.27(a)1
      1 (57.94 cM)5
    705791  NM_144530.51  NP_653113.41 
     1336198715 
    chicken
    (Gallus gallus)
    Aves ZC3H11A1 zinc finger CCCH-type containing 11A 65.55(n)
    62.85(a)
      421172  NM_001031030.1  NP_001026201.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    50(a)
    47(a)
    possible ortholog
    possible ortholog
    4(118062486-118098807)
    GL343281.1(1777450-1779473)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68112 Xenopus laevis transcribed sequence with moderate similarity more 80.86(n)    BJ618344.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc32e102 wufc32e10 76.22(n)   324551  BC059648.1 


    ENSEMBL Gene Tree for ZC3H11A (if available)
    TreeFam Gene Tree for ZC3H11A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZC3H11A gene
    1 SIMAP similar gene for ZC3H11A using alignment to 5 protein entries:     ZC11A_HUMAN (see all proteins):
    C12orf50

    ZC3H11A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZC3H11A
    PGOHUM00000244423 PGOHUM00000243660


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1277 SNPs in ZC3H11A are shown (see all 1277)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903476761,2
    --174928370(+) GTAGAC/GGCAGG 1 -- us2k10--------
    rs65939481,2
    C,F,A--174928373(+) gaggcG/Aggatt 1 -- us2k18Minor allele frequency- A:0.38NA WA CSA 16
    rs125692191,2
    C,F,H--174928501(+) ATTGGC/AAGTTG 1 -- us2k120Minor allele frequency- A:0.29NS EA NA WA 2346
    rs1389227211,2
    --174928707(+) GGTGTC/GGTGGC 1 -- us2k10--------
    rs49512331,2
    C,F,A,H--174928800(+) AAAAAT/GAAATT 1 -- us2k1 trp315Minor allele frequency- G:0.38NA WA CSA EA 518
    rs1490076911,2
    --174928811(+) GGCTAA/CCAGGA 1 -- us2k10--------
    rs49510051,2
    C,F,A,H--174928836(+) TCTGTC/TGACAT 1 -- us2k133Minor allele frequency- T:0.37NA NS EA WA CSA 2926
    rs1932613331,2
    C--174929143(+) CTAATC/TAGAGT 1 -- us2k10--------
    rs1849820611,2
    --174929173(+) AGGGGA/GACCTT 1 -- us2k10--------
    rs1457662671,2
    --174929182(+) TTGGGC/TTCCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZC3H11A (203764751 - 203823256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZC3H11A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678729CNV Deletion23128226
    esv2658459CNV Deletion23128226
    esv1633923CNV Insertion17803354
    nsv522989CNV Loss19592680
    nsv520482CNV Loss19592680
    nsv873111CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613513    OMIM disorders: --

    3 diseases for ZC3H11A:    About MalaCards
    myopia    essential hypertension    hypertension


    ZC3H11A for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZC3H11A
    Human Genome Epidemiology (HuGE) Navigator: ZC3H11A (1 document)

    Export disorders for ZC3H11A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZC3H11A gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with ZC3H11A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    2. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (2009)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9877 HGNC: 29093 AceView: KIAA0663 Ensembl:ENSG00000058673 euGenes: HUgn9877
    ECgene: ZC3H11A H-InvDB: ZC3H11A

    (According to HUGE)
    About This Section
    HUGE: KIAA0663

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZC3H11A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZC3H11A gene:
    Search GeneIP for patents involving ZC3H11A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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