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ZC3H10 Gene

protein-coding   GIFtS: 50
GCID: GC12P056547

Zinc Finger CCCH-Type Containing 10

(Previous name: zinc finger CCCH-type domain containing 10)
(Previous symbol: ZC3HDC10)
  Search for ZC3H10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger CCCH-Type Containing 101 2
ZC3HDC101 2 3
Zinc Finger CCCH-Type Domain Containing 101 2
Zinc Finger CCCH Domain-Containing Protein 102

External Ids:    HGNC: 258931   Entrez Gene: 848722   Ensembl: ENSG000001354827   UniProtKB: Q96K803   

Export aliases for ZC3H10 gene to outside databases

Previous GC identifers: GC12P054799 GC12P056512 GC12P053553 GC12P056533


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZC3H10 Gene:
ZC3H10 (zinc finger CCCH-type containing 10) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZC3H10 gene promoter:
         RFX1   Nkx2-5   Tal-1beta   c-Ets-1   CREB   deltaCREB   ITF-2   NF-Y   CBF(2)   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC3H10 promoter sequence
   Search Chromatin IP Primers for ZC3H10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZC3H10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

ZC3H10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3H10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056547:  view genomic region     (about GC identifiers)

Start:
56,511,943 bp from pter      End:
56,516,278 bp from pter
Size:
4,336 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZC3HA_HUMAN, Q96K80 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 10  
Size: 434 amino acids; 46052 Da

Explore the universe of human proteins at neXtProt for ZC3H10: NX_Q96K80

Explore proteomics data for ZC3H10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZC3H10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116175.1  
    ENSEMBL proteins: 
     ENSP00000257940   ENSP00000450122   ENSP00000448309   ENSP00000448881  

    ZC3H10 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZC3H10

     
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    Cloud-Clone Corp. ELISAs for ZC3H10
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    Search eBioscience for ELISAs for ZC3H10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC3H: Zinc fingers, CCCH-type domain containing

    1 InterPro protein domain:
     IPR000571 Znf_CCCH

    Graphical View of Domain Structure for InterPro Entry Q96K80

    ProtoNet protein and cluster: Q96K80

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: ZC3HA_HUMAN, Q96K80
    Similarity: Contains 3 C3H1-type zinc fingers


    Find genes that share domains with ZC3H10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16713569
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZC3H10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZC3H10:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZC3H10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZC3H10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZC3H10
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    miRNA
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    Block miRNA regulation of human, mouse, rat ZC3H10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZC3H10 (see all 28):
    hsa-miR-642a hsa-miR-362-3p hsa-miR-676 hsa-miR-330-5p hsa-miR-1285 hsa-miR-512-3p hsa-miR-3142 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidZC3H10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZC3H10
    Predesigned siRNA for gene silencing in human, mouse, rat ZC3H10

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ZC3H10 (NM_032786)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZC3H10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H10

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZC3H10
    Interactions:

        Search GeneGlobe Interaction Network for ZC3H10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ZC3H10 (Q96K801, 2, 3 ENSP000002579404) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-742550,EBI-930964 MINT-2877674 MINT-2877693 MINT-2877655 I2D: score=3 STRING: ENSP00000244769
    RBPMSQ930622, 3, ENSP000003401764MINT-66274 I2D: score=5 STRING: ENSP00000340176
    DAZAP2Q150383, ENSP000004049684I2D: score=1 STRING: ENSP00000404968
    FBP1P094673I2D: score=1 
    ZC3H10Q96K802MINT-67043
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZC3H10 (ZC3HA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZC3H10 gene: 
    NM_032786.1  

    Unigene Cluster for ZC3H10:

    Zinc finger CCCH-type containing 10
    Hs.632706  [show with all ESTs]
    Unigene Representative Sequence: BC018708
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257940(uc001sjp.1) ENST00000552345 ENST00000549973 ENST00000551880
    ENST00000546903
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZC3H10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZC3H10 (see all 28):
    hsa-miR-642a hsa-miR-362-3p hsa-miR-676 hsa-miR-330-5p hsa-miR-1285 hsa-miR-512-3p hsa-miR-3142 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidZC3H10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZC3H10
    Predesigned siRNA for gene silencing in human, mouse, rat ZC3H10
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZC3H10 (NM_032786)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZC3H10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC3H10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZC3H10
    OriGene qSTAR qPCR primer pairs in human, mouse for ZC3H10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZC3H10
      QuantiTect SYBR Green Assays in human, mouse, rat ZC3H10
      QuantiFast Probe-based Assays in human, mouse, rat ZC3H10

    Additional mRNA sequence: 

    AK027357.1 BC018708.1 

    9 DOTS entries:

    DT.110044  DT.121169603  DT.100833901  DT.121169464  DT.91688146  DT.100778958  DT.121169589  DT.95102735 
    DT.40207823 

    Selected AceView cDNA sequences (see all 77):

    CB148206 BC018708 AW172460 AU279921 BQ448544 BQ000497 CA455322 NM_032786 
    AA904967 BU689451 AI095114 AI392828 AI969773 AI217892 AI864180 BU621020 
    BQ073665 BX331659 AA190515 AW272428 AI758611 CR613256 BX280083 BE218067 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H10    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
    SP1:              -     -           -               
    SP2:                                -               
    SP3:              -     -                           
    SP4:                                -               


    ECgene alternative splicing isoforms for ZC3H10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZC3H10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACACTGAT
    ZC3H10 Expression
    About this image

    ZC3H10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZC3H10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632706
        Custom PCR Arrays for ZC3H10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC3H10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZC3H10 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc3h101 , 5 zinc finger CCCH type containing 101, 5 88.17(n)1
    96.54(a)1
      10 (77.01 cM)5
    1032841  NM_134003.11  NP_598764.11 
     1285419635 
    chicken
    (Gallus gallus)
    Aves ZC3H101 zinc finger CCCH-type containing 10 74.32(n)
    83.16(a)
      100858126  XM_003643122.2  XP_003643170.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZC3H106
    zinc finger CCCH-type containing 10
    83(a)
    1 ↔ 1
    GL343198.1(3760029-3761216)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.156362 Xenopus laevis transcribed sequence with weak similarity more 76.33(n)    48017983 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.193522 Transcribed sequence with moderate similarity to protein more 77.79(n)    BQ449896.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y53G8AR.96
    Protein Y53G8AR.9 (Y53G8AR.9) mRNA, complete cds
    32(a)
    1 ↔ 1
    III(3317745-3321245) WBGene00021816


    ENSEMBL Gene Tree for ZC3H10 (if available)
    TreeFam Gene Tree for ZC3H10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZC3H10 gene
    2 SIMAP similar genes for ZC3H10 using alignment to 4 protein entries:     ZC3HA_HUMAN (see all proteins):
    MKRN1    MKRN4P

    Find genes that share paralogs with ZC3H10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZC3H10 (see all 100)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441746561,2
    --56512163(+) CCGGCC/TCAGCG 1 -- int10--------
    rs38029961,2
    C,F,H--56512258(+) GACCCC/TGCATC 1 -- int13Minor allele frequency- T:0.01EA NS 298
    rs793501291,2
    C--56512307(+) CATCCC/TCTCAG 1 -- int10--------
    rs1432341751,2
    --56512524(+) TCCCAA/GTGCAC 1 -- int10--------
    rs1511747451,2
    --56512565(+) CTAGCC/TATTAC 1 -- int10--------
    rs764074631,2
    C--56512588(+) TTGGCG/CGTGCT 1 -- int12Minor allele frequency- C:0.06CSA WA 120
    rs749380621,2
    C,F--56512594(+) GTGCTC/TTGACC 1 -- int11Minor allele frequency- T:0.04EA 120
    rs111717451,2
    C,F,A,H--56512671(+) AACCCC/ATCCTC 1 -- int1 trp322Minor allele frequency- A:0.22NS EA NA WA CSA 2348
    rs1175844401,2
    C,F--56512791(+) TTTGTC/GAGATT 1 -- int11Minor allele frequency- G:0.03EA 120
    rs1930351771,2
    C--56512868(+) CCTGCG/TCAGAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZC3H10 (56511943 - 56516278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZC3H10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832427CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZC3H10
    DNA2.0 Custom Variant and Variant Library Synthesis for ZC3H10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZC3H10           About GenesLikeMe

    Genetic Association Database (GAD): ZC3H10
    Human Genome Epidemiology (HuGE) Navigator: ZC3H10 (1 document)

    Export disorders for ZC3H10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZC3H10 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZC3H10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    6. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. (PubMed id 21779181)4 Gorlova O....Martin J. (PLoS Genet. 2011)
    7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    9. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    10. Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration. (PubMed id 18814840)1 Guardiola-Serrano F....Altschmied J. (Biochem. Biophys. Res. Commun. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84872 HGNC: 25893 AceView: FLJ14451 Ensembl:ENSG00000135482 euGenes: HUgn84872
    ECgene: ZC3H10 H-InvDB: ZC3H10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZC3H10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZC3H10 gene:
    Search GeneIP for patents involving ZC3H10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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