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ZC3H10 Gene

protein-coding   GIFtS: 50

GC12P054799
zinc finger CCCH-type containing 10
(Previous name: zinc finger CCCH-type domain containing 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZC3HDC10)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ14451 1, 2
ZC3HDC10 2, 3
Descriptions
zinc finger CCCH-type containing 10 2
zinc finger CCCH-type domain containing 10 1, 2
External Ids
HGNC: 258931
Entrez Gene: 848722
UniProtKB: Q96K803
Ensembl: ENSG000001354827
Search outside databases for aliases for ZC3H10 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZC3H10 gene  

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

ZC3H10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054799:     (about GC identifiers)

Start:
54,798,297 bp from pter
End:
54,802,545 bp from pter
Size:
4,249 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZC3HA_HUMAN, Q96K80 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 10  
Size: 434 amino acids; 46052 Da

REFSEQ proteins: NP_116175.1  

ENSEMBL proteins: 
ENSP00000257940 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ZC3H10)
Human Recombinant Proteins from Abnova (ZC3H10)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for ZC3H10: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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Antibodies from Abcam (ZC3H10), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (ZC3H10)
Novus Biologicals Antibody for ZC3H10

Assays for ZC3H10: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR000571 Znf_CCCH


   GeneDecks  ZC3H10 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q96K80

ProtoNet protein and cluster: Q96K80

1 Blocks protein family: IPB000571 Zn-finger

UniProtKB/Swiss-Prot: ZC3HA_HUMAN, Q96K80
Similarity: Contains 3 C3H1-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZC3H10)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZC3H10)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032786

              Applied Biosystems Silencer® siRNAs for ZC3H10

              Sigma-Aldrich siRNA for ZC3H10  
                     Sigma-Aldrich shRNA for ZC3H10  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for ZC3H10
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032786
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032786
                                 untagged cDNA clone in CMV expression vector: NM_032786 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_032786

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003676 nucleic acid binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Interacting proteins for ZC3H10 (Q96K802) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
ATXN1P542532MINT-2877674 MINT-2877693 MINT-2877655
RBPMSQ930622MINT-66274
ZC3H10Q96K802MINT-67043
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZC3H10

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZC3H10)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZC3H10)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032786

              Sigma-Aldrich siRNA for ZC3H10  
                     Sigma-Aldrich shRNA for ZC3H10  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_032786  

REFSEQ mRNAs for ZC3H10 gene: 

NM_032786.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_032786  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032786
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032786
                                 untagged cDNA clone in CMV expression vector: NM_032786 

Additional cDNA sequence: 

AK027357.1 BC018708.1 CR613256.1 

8 DOTS entries:

DT.110044  DT.121169603  DT.100833901  DT.121169464  DT.91688146  DT.100778958  DT.121169589  DT.95102735 

24/77 AceView cDNA sequences (see all 77 ):

CR613256 BC018708 AK027357 BU689451 AI095114 AI392828 AI758611 AW172460 
BQ000497 BU621020 BQ073665 AI864180 AU279921 AA190515 BX280083 AA904967 
AI969773 CB148206 CA455322 AW272428 BX331659 AI217892 BE218067 BQ448544 

highest scoring ESTs for ZC3H10:

AI969773 AA035449 AA035476 AA190841 AA653919 AA654323 AI091077 AI192987 AI392828 AI758611 

Unigene Cluster for ZC3H10:

Zinc finger CCCH-type containing 10
Hs.632706  [show with all ESTs]
Unigene Representative Sequence: BC018708


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H10

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1:              -     -           -               
SP2:                                -               
SP3:              -     -                           
SP4:                                -               

About this scheme

ECgene alternative splicing isoforms for ZC3H10

1 Ensembl transcript including schematic representation:
ENST00000257940  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZC3H10 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H10

1 / 2 / 3

3 probe-sets matching ZC3H10 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
57659_at2, 3 U95-C 1 0.81 1.00 1.00 1.00 AI969773 1.00 1.00 1.00 1

227430_at2, 3 U133-B 1 1.00 1.00 -- -- AI969773 1.00 1.00 1.00 1

227430_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  ZC3H10 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCACACTGAT

SOURCE GeneReport for Unigene cluster: Hs.632706
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ZC3H10 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ZC3H101   -- zinc finger CCCH-type containing 10 94.16(n)
97.24(a)
481106  XM_538227.2  XP_538227.1 
chimpanzee
(Pan troglodytes)
ZC3H101   -- zinc finger CCCH-type containing 10 99.62(n)
99.77(a)
451982  XM_509133.2  XP_509133.2 
cow
(Bos taurus)
ZC3H101   -- zinc finger CCCH-type containing 10 93.7(n)
97.47(a)
507466  XM_584071.3  XP_584071.2 
rat
(Rattus norvegicus)
Zc3h101   -- zinc finger CCCH type containing 10 89.63(n)
96.54(a)
685928  XM_001065797.1  XP_001065797.1 
mouse
(Mus musculus)
Zc3h101, 5 105
zinc finger CCCH type containing 101, 5 88.71(n)1
97.24(a)1
1032841  NM_134003.11  NP_598764.11 
 AA3881655  AI1156235  (see all 10)
About this table        Species with no ortholog for ZC3H10

ENSEMBL Gene Tree for ZC3H10
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10 NCBI SNPs in ZC3H10 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs111717461,2
A,C,F,H54802423(+) GGGAAA/GGCTGG 1 -- ut314Minor allele frequency- G:0.04EU EA WA 412
rs10485391,2
C,H54802029(+) GAACTA/GGGACA 1 -- ut313Minor allele frequency- G:0.00MN EA 362
rs111717451,2
A,C,F,H54798938(+) AACCCC/ATCCTC 1 -- int1 trp32Minor allele frequency- A:0.33EU WA 236
rs38029961,2
F,H54798525(+) GACCCC/TGCATC 1 -- int13Minor allele frequency- T:0.01EA WA 298
--
rs122981361,2
--54803037(+) TGAAGC/GCTTCA 1 -- ng310--------
rs617322941,2
--54800927(+) TGGCTA/GTAAGA 1 Y/C mis10--------
--
rs580631981,2
--54802796(+) TCTGT-/CTGT  
        
ATGTG
1 -- ng310--------
--
rs572805851,2
--54802836(+) GGGCTC/GCTAGG 1 -- ng310--------
--
rs740945391,2
--54801207(+) GACAGA/GGGCTT 1 R/R syn10--------
--
rs360993651,2
--54799717(+) CTCTT-/GGGGAA 1 -- int10--------
About this table
The following additional 16 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs3809131 rs12296387 rs3809130 rs2640569 rs7488465 rs3809132 rs17118313
 rs11171747 rs10747761 rs3809133 rs4759228 rs12297842 rs1689513 rs773120
 rs1689512 rs17118317

HapMap Linkage Disequilibrium images for ZC3H10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: ZC3H10 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

7 PubMed articles for ZC3H10 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 84872 HGNC: 25893 AceView: FLJ14451 Ensembl:ENSG00000135482 euGenes: HUgn84872
ECgene: ZC3H10 H-InvDB: ZC3H10
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ZC3H10:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for ZC3H10 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for ZC3H10 Browse small molecules at Sigma-Aldrich
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 Antibodies for ZC3H10

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