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ZC3H10 Gene

protein-coding GIFtS: 50

GC12P054799

zinc finger CCCH-type containing 10
(Previous name: zinc finger CCCH-type domain containing 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZC3HDC10)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ14451 ^¹, ²
ZC3HDC10 ^², ³

Descriptions
zinc finger CCCH-type containing 10 ^²
zinc finger CCCH-type domain containing 10 ^¹, ²

External Ids
HGNC: 25893¹
Entrez Gene: 84872²
UniProtKB: Q96K80³
Ensembl: ENSG00000135482⁷

Search outside databases for aliases for ZC3H10 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZC3H10 gene

Entrez Gene cytogenetic band: 12q13.2 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.2

ZC3H10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P054799: (about GC identifiers)

Start:	54,798,297 bp from pter
End:	54,802,545 bp from pter
Size:	4,249 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZC3HA_HUMAN, Q96K80 (See protein sequence)

Recommended Name: Zinc finger CCCH domain-containing protein 10

Size: 434 amino acids; 46052 Da

REFSEQ proteins: NP_116175.1

ENSEMBL proteins:

ENSP00000257940

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZC3H10)
	Human Recombinant Proteins from Abnova (ZC3H10)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ZC3H10:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZC3H10), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZC3H10)
	Novus Biologicals Antibody for ZC3H10

Assays for ZC3H10:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96K80

ProtoNet protein and cluster: Q96K80

1 Blocks protein family: IPB000571 Zn-finger

UniProtKB/Swiss-Prot: ZC3HA_HUMAN, Q96K80

Similarity: Contains 3 C3H1-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZC3H10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032786

Applied Biosystems Silencer® siRNAs for ZC3H10

Sigma-Aldrich siRNA for ZC3H10

Sigma-Aldrich shRNA for ZC3H10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZC3H10
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_032786
Myc/DDK tagged cDNA clone in CMV expression vector: NM_032786
untagged cDNA clone in CMV expression vector: NM_032786

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032786

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Interacting proteins for ZC3H10 (Q96K80²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
ATXN1 P54253² MINT-2877674 MINT-2877693 MINT-2877655
RBPMS Q93062² MINT-66274
ZC3H10 Q96K80² MINT-67043
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZC3H10

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZC3H10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZC3H10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032786

Sigma-Aldrich siRNA for ZC3H10

Sigma-Aldrich shRNA for ZC3H10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032786

REFSEQ mRNAs for ZC3H10 gene:

NM_032786.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032786

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032786
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032786
                                 untagged cDNA clone in CMV expression vector: NM_032786

Additional cDNA sequence:

AK027357.1 BC018708.1 CR613256.1

8 DOTS entries:

DT.110044 DT.121169603 DT.100833901 DT.121169464 DT.91688146 DT.100778958 DT.121169589 DT.95102735

24/77 AceView cDNA sequences (see all 77 ):

CR613256 BC018708 AK027357 BU689451 AI095114 AI392828 AI758611 AW172460

BQ000497 BU621020 BQ073665 AI864180 AU279921 AA190515 BX280083 AA904967

AI969773 CB148206 CA455322 AW272428 BX331659 AI217892 BE218067 BQ448544

highest scoring ESTs for ZC3H10:

AI969773 AA035449 AA035476 AA190841 AA653919 AA654323 AI091077 AI192987 AI392828 AI758611

Unigene Cluster for ZC3H10:

Zinc finger CCCH-type containing 10

Hs.632706 [show with all ESTs]

Unigene Representative Sequence: BC018708

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H10

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b
SP1:					-		-				-
SP2:											-
SP3:					-		-
SP4:											-

About this scheme

ECgene alternative splicing isoforms for ZC3H10

1 Ensembl transcript including schematic representation:

ENST00000257940

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZC3H10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZC3H10

¹ / ² / ³

3 probe-sets matching ZC3H10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57659_at²^{, 3}	U95-C	1	0.81	1.00	1.00	1.00	AI969773	1.00	1.00	1.00	1
227430_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI969773	1.00	1.00	1.00	1
227430_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZC3H10 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCACACTGAT

SOURCE GeneReport for Unigene cluster: Hs.632706

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZC3H10 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZC3H10¹	--	zinc finger CCCH-type containing 10	94.16(n) 97.24(a)	481106 XM_538227.2 XP_538227.1
chimpanzee (Pan troglodytes)	ZC3H10¹	--	zinc finger CCCH-type containing 10	99.62(n) 99.77(a)	451982 XM_509133.2 XP_509133.2
cow (Bos taurus)	ZC3H10¹	--	zinc finger CCCH-type containing 10	93.7(n) 97.47(a)	507466 XM_584071.3 XP_584071.2
rat (Rattus norvegicus)	Zc3h10¹	--	zinc finger CCCH type containing 10	89.63(n) 96.54(a)	685928 XM_001065797.1 XP_001065797.1
mouse (Mus musculus)	Zc3h10^{1, 5}	10⁵	zinc finger CCCH type containing 10^{1, 5}	88.71(n)¹ 97.24(a)¹	103284¹ NM_134003.1¹ NP_598764.1¹ AA388165⁵ AI115623⁵ (see all 10)

About this table Species with no ortholog for ZC3H10

ENSEMBL Gene Tree for ZC3H10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10 NCBI SNPs in ZC3H10 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11171746^1,2	A,C,F,H	54802423(+)	`GGGAAA/GGCTGG`	1	--	ut3¹		4		EU EA WA	412
	rs1048539^1,2	C,H	54802029(+)	`GAACTA/GGGACA`	1	--	ut3¹		3		MN EA	362
	rs11171745^1,2	A,C,F,H	54798938(+)	`AACCCC/ATCCTC`	1	--	int¹ trp³		2		EU WA	236
	rs3802996^1,2	F,H	54798525(+)	`GACCCC/TGCATC`	1	--	int¹		3		EA WA	298
--	rs12298136^1,2	--	54803037(+)	`TGAAGC/GCTTCA`	1	--	ng3¹		0	--	--	--	--
	rs61732294^1,2	--	54800927(+)	`TGGCTA/GTAAGA`	1	Y/C	mis¹		0	--	--	--	--
--	rs58063198^1,2	--	54802796(+)	`TCTGT-/CTGT ATGTG`	1	--	ng3¹		0	--	--	--	--
--	rs57280585^1,2	--	54802836(+)	`GGGCTC/GCTAGG`	1	--	ng3¹		0	--	--	--	--
--	rs74094539^1,2	--	54801207(+)	`GACAGA/GGGCTT`	1	R/R	syn¹		0	--	--	--	--
--	rs36099365^1,2	--	54799717(+)	`CTCTT-/GGGGAA`	1	--	int¹		0	--	--	--	--

About this table
The following additional 16 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs3809131	rs12296387	rs3809130	rs2640569	rs7488465	rs3809132	rs17118313
rs11171747	rs10747761	rs3809133	rs4759228	rs12297842	rs1689513	rs773120
rs1689512	rs17118317

HapMap Linkage Disequilibrium images for ZC3H10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: ZC3H10 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for ZC3H10 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)³ Trynka G....Wijmenga C. (2009)
Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration. (PubMed id 18814840)³ Guardiola-Serrano F....Altschmied J. (2008)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)³ Lim J....Zoghbi H.Y. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 84872	HGNC: 25893	AceView: FLJ14451	Ensembl:ENSG00000135482	euGenes: HUgn84872
ECgene: ZC3H10	H-InvDB: ZC3H10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZC3H10
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZC3H10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZC3H10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZC3H10		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZC3H10		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ZC3H10)
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ZC3H10 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for ZC3H10

Summaries
for ZC3H10

Genomic Location
for ZC3H10

Proteins
for ZC3H10

Protein Domains/
Families
for ZC3H10

Gene Function
for ZC3H10

Pathways & Interactions
for ZC3H10

Drugs & Compounds
for ZC3H10

Transcripts
for ZC3H10

Expression
for ZC3H10

Orthologs
for ZC3H10

Paralogs
for ZC3H10

SNPs/Variants
for ZC3H10

Disorders & Mutations
for ZC3H10

Medical News
for ZC3H10

Publications
for ZC3H10

Search for ZC3H10

Genome Databases showing ZC3H10

Other Databases showing ZC3H10

Specialized Databases showing ZC3H10

Licensable Technologies
for ZC3H10

Services
for ZC3H10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZC3H10 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor ZC3H10

Summariesfor ZC3H10

Genomic Locationfor ZC3H10

Proteinsfor ZC3H10

Protein Domains/Familiesfor ZC3H10

Gene Functionfor ZC3H10

Pathways & Interactionsfor ZC3H10

Drugs & Compoundsfor ZC3H10

Transcriptsfor ZC3H10

Expression for ZC3H10

Orthologsfor ZC3H10

Paralogsfor ZC3H10

SNPs/Variantsfor ZC3H10

Disorders & Mutationsfor ZC3H10

Medical Newsfor ZC3H10

Publicationsfor ZC3H10

Search for ZC3H10

Genome Databases showing ZC3H10

Other Databases showing ZC3H10

Specialized Databases showing ZC3H10

Licensable Technologiesfor ZC3H10

Servicesfor ZC3H10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZC3H10

Summaries
for ZC3H10

Genomic Location
for ZC3H10

Proteins
for ZC3H10

Protein Domains/
Families
for ZC3H10

Gene Function
for ZC3H10

Pathways & Interactions
for ZC3H10

Drugs & Compounds
for ZC3H10

Transcripts
for ZC3H10

Expression
for ZC3H10

Orthologs
for ZC3H10

Paralogs
for ZC3H10

SNPs/Variants
for ZC3H10

Disorders & Mutations
for ZC3H10

Medical News
for ZC3H10

Publications
for ZC3H10

Licensable Technologies
for ZC3H10

Services
for ZC3H10