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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZC2HC1C Gene

protein-coding GIFtS: 40
GCID: GC14P075530

zinc finger, C2HC-type containing 1C

(Previous names: chromosome 14 open reading frame 140, family with sequence...)
(Previous symbols: C14orf140, FAM164C)

Search for ZC2HC1C
in

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger, C2HC-Type Containing 1C¹ ²		Chromosome 14 Open Reading Frame 140¹
C14orf140¹ ² ³		Protein FAM164C²
FAM164C¹ ² ³		Zinc Finger C2HC Domain-Containing Protein 1C²
Family With Sequence Similarity 164, Member C¹ ²

External Ids:	HGNC: 20354¹	Entrez Gene: 79696²	Ensembl: ENSG00000119703⁷	UniProtKB: Q53FD0³

Export aliases for ZC2HC1C gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZC2HC1C
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZC2HC1C promoter sequence

Search SABiosciences Chromatin IP Primers for ZC2HC1C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC2HC1C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3

ZC2HC1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC2HC1C gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P075530: view genomic region (about GC identifiers)

Start:	75,530,873 bp from pter	End:	75,545,126 bp from pter
Size:	14,254 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZC21C_HUMAN, Q53FD0 (See protein sequence)

Recommended Name: Zinc finger C2HC domain-containing protein 1C

Size: 456 amino acids; 51658 Da

Sequence caution: Sequence=BAB15541.1; Type=Frameshift; Positions=Several;

Secondary accessions: E9PJQ0 Q9BTA8 Q9H5S9

Alternative splicing: 2 isoforms: Q53FD0-1 Q53FD0-2

Explore the universe of human proteins at neXtProt for ZC2HC1C: NX_Q53FD0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q53FD0

ZC2HC1C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001035895.1 NP_078919.2

ENSEMBL proteins:

ENSP00000434997 ENSP00000435550 ENSP00000238686 ENSP00000451195 ENSP00000390606

ENSP00000437160 ENSP00000435684 ENSP00000434733

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZC2HC1C for domains About GeneDecksing

1 InterPro domain/family:

IPR026104 ZNF_C2HC_dom_1C

Graphical View of Domain Structure for InterPro Entry Q53FD0

ProtoNet protein and cluster: Q53FD0

UniProtKB/Swiss-Prot: ZC21C_HUMAN, Q53FD0

Similarity: Belongs to the ZC2HC1 family

Similarity: Contains 1 C2HC-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0046872	metal ion binding	IEA	--

ZC2HC1C for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC2HC1C

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZC2HC1C

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for ZC2HC1C (Q53FD0³ ENSP00000238686⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC85B	Q15834³, ENSP00000311695⁴	I2D: score=4 STRING: ENSP00000311695
KRT15	P19012³, ENSP00000254043⁴	I2D: score=4 STRING: ENSP00000254043
KRT20	P35900³, ENSP00000167588⁴	I2D: score=4 STRING: ENSP00000167588
CALCOCO2	Q13137³, ENSP00000258947⁴	I2D: score=4 STRING: ENSP00000258947
MTUS2	Q5JR59³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZC2HC1C
Search CenterWatch for drugs/clinical trials and news about ZC2HC1C / ZC21C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZC2HC1C gene (2 alternative transcripts):

NM_001042430.1 NM_024643.2

Unigene Cluster for ZC2HC1C:

Zinc finger, C2HC-type containing 1C

Hs.48642 [show with all ESTs]

Unigene Representative Sequence: NM_024643

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534151 ENST00000524913(uc001xrh.3) ENST00000238686(uc001xri.3)

ENST00000554763 ENST00000439583 ENST00000526130 ENST00000526748 ENST00000525046

ENST00000532198

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Additional cDNA sequence:

AK026746.1 AK223359.1 AK303882.1 BC004259.1

6 DOTS entries:

DT.108547 DT.100747136 DT.91693546 DT.100714655 DT.120731095 DT.95164499

24/50 AceView cDNA sequences (see all 50):

BQ187094 AA993354 BC004259 BF726751 BM977278 AI084531 AW150883 AI625162

AI701484 BM559464 BX474338 BI464669 BE390050 BI462489 BP371558 BP362818

BM981794 AK026746 NM_024643 AI674668 BG200223 BP369867 BI561762 BG767100

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC2HC1C About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	·	2d	^	3	^	4
SP1:							-								-		-
SP2:							-										-
SP3:
SP4:							-		-		-		-		-		-
SP5:															-

ECgene alternative splicing isoforms for ZC2HC1C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZC2HC1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGAAAAAA

About this image

ZC2HC1C expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZC2HC1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZC2HC1C

SOURCE GeneReport for Unigene cluster: Hs.48642

SABiosciences Custom PCR Arrays for ZC2HC1C

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZC2HC1C gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FAM164C¹	family with sequence similarity 164, member C	56.85(n) 44.64(a)		428890 XM_426446.3 XP_426446.2
lizard (Anolis carolinensis)	Reptilia	FAM164C⁶	--	28(a)	1 ↔ 1	1(22597139-22599629)
zebrafish (Danio rerio)	Actinopterygii	LOC799591¹	protein FAM164C-like	47.59(n) 32.07(a)		799591 XM_001339894.3 XP_001339930.3
fruit fly (Drosophila melanogaster)	Insecta	CG42675⁶	--	13(a)	1 ↔ 1	3R(1639544-1644545)

ENSEMBL Gene Tree for ZC2HC1C (if available)
TreeFam Gene Tree for ZC2HC1C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZC2HC1C gene

ZC2HC1B² ZC2HC1A²

ZC2HC1C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10131391^1,2	C,F	--	75534343(+)	`GGGAAA/CGTTGA`	2	--	us2k¹ tfbs³		1		WA	118
rs116812405^1,2	F	--	75534350(+)	`TTGAGT/CATATG`	2	--	us2k¹		1		WA	118
rs149976664^1,2		--	75534354(+)	`GTATAG/TGTTAA`	2	--	us2k¹		0	--	--	--	--
rs57223041^1,2	C	--	75534389(+)	`GAGGTA/GTAACT`	2	--	us2k¹		2		WA	120
rs118006193^1,2		--	75534401(+)	`GAAGTT/CAACAA`	2	--	us2k¹		1		EA	120
rs175500^1,2	C,F,H	--	75534437(+)	`CGTCTA/GTAATC`	2	--	us2k¹		8		EA NS NA	716
rs76738275^1,2	F	--	75534465(+)	`TGAGGC/TGGGAG`	2	--	us2k¹		1		WA	118
rs79352331^1,2	F	--	75534506(+)	`AGCCTG/CGGTAA`	2	--	us2k¹		1		WA	118
rs114694973^1,2		--	75534648(+)	`AGTGAG/ACAGTG`	2	--	us2k¹		1		WA	118
rs189160850^1,2		--	75534692(+)	`GTGAGA/GCCCTG`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZC2HC1C (75530873 - 75545126 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZC2HC1C: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZC2HC1C gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZC2HC1C)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79696	HGNC: 20354	AceView: C14orf140	Ensembl:ENSG00000119703	euGenes: HUgn79696
ECgene: ZC2HC1C	H-InvDB: ZC2HC1C

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZC2HC1C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZC2HC1C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZC2HC1C gene:
Search GeneIP for patents involving ZC2HC1C

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZC2HC1C gene at Home site.

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ZC2HC1C Gene

zinc finger, C2HC-type containing 1C

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ZC2HC1C Gene

zinc finger, C2HC-type containing 1C

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