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ZC2HC1C Gene

protein-coding   GIFtS: 39
GCID: GC14P075530

Zinc Finger, C2HC-Type Containing 1C

(Previous names: chromosome 14 open reading frame 140, family with sequence...)
(Previous symbols: C14orf140, FAM164C)
  Search for ZC2HC1C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, C2HC-Type Containing 1C1 2     Chromosome 14 Open Reading Frame 1401
C14orf1401 2 3     Protein FAM164C2
FAM164C1 2 3     Zinc Finger C2HC Domain-Containing Protein 1C2
Family With Sequence Similarity 164, Member C1 2     

External Ids:    HGNC: 203541   Entrez Gene: 796962   Ensembl: ENSG000001197037   UniProtKB: Q53FD03   

Export aliases for ZC2HC1C gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZC2HC1C Gene:
ZC2HC1C (zinc finger, C2HC-type containing 1C) is a protein-coding gene. An important paralog of this gene is ZC2HC1B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZC2HC1C
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC2HC1C promoter sequence
   Search Chromatin IP Primers for ZC2HC1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZC2HC1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

ZC2HC1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC2HC1C gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P075530:  view genomic region     (about GC identifiers)

Start:
75,530,873 bp from pter      End:
75,545,126 bp from pter
Size:
14,254 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZC21C_HUMAN, Q53FD0 (See protein sequence)
Recommended Name: Zinc finger C2HC domain-containing protein 1C  
Size: 456 amino acids; 51658 Da
Sequence caution: Sequence=BAB15541.1; Type=Frameshift; Positions=Several;
Secondary accessions: E9PJQ0 Q9BTA8 Q9H5S9
Alternative splicing: 2 isoforms:  Q53FD0-1   Q53FD0-2   

Explore the universe of human proteins at neXtProt for ZC2HC1C: NX_Q53FD0

Explore proteomics data for ZC2HC1C at MOPED


See ZC2HC1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001035895.1  NP_078919.2  

ENSEMBL proteins: 
 ENSP00000434997   ENSP00000435550   ENSP00000238686   ENSP00000451195   ENSP00000390606  
 ENSP00000437160   ENSP00000435684   ENSP00000434733  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZC2HC: Zinc fingers, C2HC-type containing

1 InterPro protein domain:
 IPR026104 ZNF_C2HC_dom_1C

Graphical View of Domain Structure for InterPro Entry Q53FD0

ProtoNet protein and cluster: Q53FD0

UniProtKB/Swiss-Prot: ZC21C_HUMAN, Q53FD0
Similarity: Belongs to the ZC2HC1 family
Similarity: Contains 1 C2HC-type zinc finger


ZC2HC1C for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0046872metal ion binding IEA--
     
ZC2HC1C for ontologies           About GeneDecksing


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZC2HC1C
Interactions:

    Search GeneGlobe Interaction Network for ZC2HC1C

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for ZC2HC1C (Q53FD03 ENSP000002386864) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
KRT15P190123, ENSP000002540434I2D: score=4 STRING: ENSP00000254043
KRT20P359003, ENSP000001675884I2D: score=4 STRING: ENSP00000167588
CALCOCO2Q131373, ENSP000002589474I2D: score=4 STRING: ENSP00000258947
MTUS2Q5JR593I2D: score=1 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZC2HC1C (ZC21C)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZC2HC1C gene (2 alternative transcripts): 
NM_001042430.2  NM_024643.3  

Unigene Cluster for ZC2HC1C:

Zinc finger, C2HC-type containing 1C
Hs.48642  [show with all ESTs]
Unigene Representative Sequence: NM_024643
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000534151 ENST00000524913(uc001xrh.3) ENST00000238686(uc001xri.3)
ENST00000554763 ENST00000439583 ENST00000526130 ENST00000526748 ENST00000525046
ENST00000532198
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Additional mRNA sequence: 

AK026746.1 AK223359.1 AK303882.1 BC004259.1 

6 DOTS entries:

DT.108547  DT.100747136  DT.91693546  DT.100714655  DT.120731095  DT.95164499 

Selected AceView cDNA sequences (see all 50):

AW150883 AI625162 BF726751 BM977278 AA993354 BC004259 AI084531 BQ187094 
BE390921 W01324 BQ063866 BM981794 BQ642059 BX474338 BF726750 BX110341 
BP371558 AI050689 BQ061857 BI561762 BE388817 BG767100 BI462489 BP362818 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZC2HC1C    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4
SP1:                    -                       -     -         
SP2:                    -                             -         
SP3:                                                            
SP4:                    -     -     -     -     -     -         
SP5:                                            -               


ECgene alternative splicing isoforms for ZC2HC1C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZC2HC1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTGAAAAAA
ZC2HC1C Expression
About this image

ZC2HC1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZC2HC1C Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.48642
    Custom PCR Arrays for ZC2HC1C
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ZC2HC1C gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zc2hc1c1 , 5 family with sequence similarity 164, member C5
zinc finger, C2HC-type containing 1C1
75.71(n)1
63.68(a)1
  12 (39.63 cM)5
723501  NM_172414.41  NP_766002.21 
 852885915 
chicken
(Gallus gallus)
Aves FAM164C1 family with sequence similarity 164, member C 51.37(n)
39.49(a)
  428890  XM_426446.4  XP_426446.3 
lizard
(Anolis carolinensis)
Reptilia ZC2HC1C6
zinc finger, C2HC-type containing 1C
26(a)
1 ↔ 1
1(22597007-22606710)
tropical clawed frog
(Xenopus tropicalis)
Amphibia zc2hc1c1 zinc finger, C2HC-type containing 1C 54.76(n)
54.29(a)
  100492184  XM_002938590.2  XP_002938636.2 
zebrafish
(Danio rerio)
Actinopterygii LOC7995911 zinc finger C2HC domain-containing protein 1C-like 51.32(n)
44.44(a)
  799591  XM_001339894.4  XP_001339930.3 
fruit fly
(Drosophila melanogaster)
Insecta CG426756
--
18(a)
1 ↔ 1
3R(1639544-1644545)


ENSEMBL Gene Tree for ZC2HC1C (if available)
TreeFam Gene Tree for ZC2HC1C (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZC2HC1C gene
ZC2HC1B2  ZC2HC1A2  

ZC2HC1C for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZC2HC1C (see all 234)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs101313911,2
C,F--75534343(+) GGGAAA/CGTTGA 2 -- us2k1 tfbs31Minor allele frequency- C:0.11WA 118
rs1168124051,2
C,F--75534350(+) TTGAGT/CATATG 2 -- us2k11Minor allele frequency- C:0.03WA 118
rs1499766641,2
--75534354(+) GTATAG/TGTTAA 2 -- us2k10--------
rs572230411,2
C,F--75534389(+) GAGGTA/GTAACT 2 -- us2k12Minor allele frequency- G:0.10WA 120
rs1180061931,2
F--75534401(+) GAAGTT/CAACAA 2 -- us2k11Minor allele frequency- C:0.01EA 120
rs1755001,2
C,F,H--75534437(+) cgtctA/Gtaatc 2 -- us2k18Minor allele frequency- G:0.37EA NS NA 716
rs767382751,2
F--75534465(+) TGAGGC/TGGGAG 2 -- us2k11Minor allele frequency- T:0.02WA 118
rs793523311,2
C,F--75534506(+) AGCCTG/CGGTAA 2 -- us2k11Minor allele frequency- C:0.03WA 118
rs1146949731,2
F--75534648(+) AGTGAG/ACAGTG 2 -- us2k11Minor allele frequency- A:0.01WA 118
rs1891608501,2
--75534692(+) GTGAGA/GCCCTG 2 -- us2k10--------

HapMap Linkage Disequilibrium report for ZC2HC1C (75530873 - 75545126 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ZC2HC1C: --
Human Gene Mutation Database (HGMD): ZC2HC1C
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing ZC2HC1C
DNA2.0 Custom Variant and Variant Library Synthesis for ZC2HC1C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ZC2HC1C for disorders           About GeneDecksing


Export disorders for ZC2HC1C gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZC2HC1C gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZC2HC1C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79696 HGNC: 20354 AceView: C14orf140 Ensembl:ENSG00000119703 euGenes: HUgn79696
ECgene: ZC2HC1C H-InvDB: ZC2HC1C

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZC2HC1C Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZC2HC1C gene:
Search GeneIP for patents involving ZC2HC1C

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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