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Aliases for ZC2HC1C Gene

Aliases for ZC2HC1C Gene

  • Zinc Finger C2HC-Type Containing 1C 2 3 5
  • Family With Sequence Similarity 164, Member C 2 3
  • C14orf140 3 4
  • FAM164C 3 4
  • Zinc Finger C2HC Domain-Containing Protein 1C 3
  • Chromosome 14 Open Reading Frame 140 2
  • Protein FAM164C 3

External Ids for ZC2HC1C Gene

Previous HGNC Symbols for ZC2HC1C Gene

  • C14orf140
  • FAM164C

Previous GeneCards Identifiers for ZC2HC1C Gene

  • GC14P075530

Summaries for ZC2HC1C Gene

GeneCards Summary for ZC2HC1C Gene

ZC2HC1C (Zinc Finger C2HC-Type Containing 1C) is a Protein Coding gene. An important paralog of this gene is ZC2HC1B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC2HC1C Gene

Genomics for ZC2HC1C Gene

Regulatory Elements for ZC2HC1C Gene

Enhancers for ZC2HC1C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G075181 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.5 +119.5 119534 4.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 EIF2B2 ZC2HC1C ACYP1 FOS ENSG00000273565 RNU4ATAC14P
GH14G075123 1 ENCODE dbSUPER 28.1 +60.1 60129 1.4 CTCF ATF1 JUN FOSL1 GATA2 POLR2A FOSL2 ZNF600 FOS SMARCE1 ZC2HC1C EIF2B2 ACYP1 RPS6KL1 JDP2 MLH3 ENSG00000259138 HIF1AP1
GH14G075174 1.4 ENCODE dbSUPER 17.2 +111.7 111705 3.4 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZC2HC1C ENSG00000258559 PROX2 ACYP1 RPS6KL1 TMED10 NEK9
GH14G075147 1.3 Ensembl ENCODE dbSUPER 18.3 +83.8 83771 2.9 ELF3 SOX13 DRAP1 CTCF ZNF792 SAP130 TEAD4 ARID4B DMAP1 RAD21 ZC2HC1C EIF2B2 TMED10 NEK9 BATF JDP2 ACYP1
GH14G075125 1.4 ENCODE dbSUPER 16.6 +62.8 62790 3.5 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B EIF2B2 ZC2HC1C ACYP1 ENSG00000259138 HIF1AP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC2HC1C on UCSC Golden Path with GeneCards custom track

Promoters for ZC2HC1C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070849 -370 1201 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 ZNF143 FOS

Genomic Location for ZC2HC1C Gene

Chromosome:
14
Start:
75,064,170 bp from pter
End:
75,079,987 bp from pter
Size:
15,818 bases
Orientation:
Plus strand

Genomic View for ZC2HC1C Gene

Genes around ZC2HC1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC2HC1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC2HC1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC2HC1C Gene

Proteins for ZC2HC1C Gene

  • Protein details for ZC2HC1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53FD0-ZC21C_HUMAN
    Recommended name:
    Zinc finger C2HC domain-containing protein 1C
    Protein Accession:
    Q53FD0
    Secondary Accessions:
    • E9PJQ0
    • Q9BTA8
    • Q9H5S9

    Protein attributes for ZC2HC1C Gene

    Size:
    456 amino acids
    Molecular mass:
    51658 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15541.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for ZC2HC1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZC2HC1C Gene

Post-translational modifications for ZC2HC1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZC2HC1C Gene

Domains & Families for ZC2HC1C Gene

Gene Families for ZC2HC1C Gene

Protein Domains for ZC2HC1C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC2HC1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53FD0

UniProtKB/Swiss-Prot:

ZC21C_HUMAN :
  • Belongs to the ZC2HC1 family.
Family:
  • Belongs to the ZC2HC1 family.
genes like me logo Genes that share domains with ZC2HC1C: view

Function for ZC2HC1C Gene

Gene Ontology (GO) - Molecular Function for ZC2HC1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC2HC1C: view

Phenotypes for ZC2HC1C Gene

GenomeRNAi human phenotypes for ZC2HC1C:
genes like me logo Genes that share phenotypes with ZC2HC1C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC2HC1C Gene

Localization for ZC2HC1C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC2HC1C gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZC2HC1C Gene

Pathways & Interactions for ZC2HC1C Gene

SuperPathways for ZC2HC1C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC2HC1C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZC2HC1C Gene

Transcripts for ZC2HC1C Gene

Unigene Clusters for ZC2HC1C Gene

Zinc finger, C2HC-type containing 1C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC2HC1C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4
SP1: - - -
SP2: - -
SP3:
SP4: - - - - - -
SP5: -

Relevant External Links for ZC2HC1C Gene

GeneLoc Exon Structure for
ZC2HC1C
ECgene alternative splicing isoforms for
ZC2HC1C

Expression for ZC2HC1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC2HC1C Gene

mRNA differential expression in normal tissues according to GTEx for ZC2HC1C Gene

This gene is overexpressed in Testis (x16.2).

Protein differential expression in normal tissues from HIPED for ZC2HC1C Gene

This gene is overexpressed in Colon muscle (57.0) and Platelet (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZC2HC1C Gene



Protein tissue co-expression partners for ZC2HC1C Gene

NURSA nuclear receptor signaling pathways regulating expression of ZC2HC1C Gene:

ZC2HC1C

SOURCE GeneReport for Unigene cluster for ZC2HC1C Gene:

Hs.48642

Evidence on tissue expression from TISSUES for ZC2HC1C Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZC2HC1C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC2HC1C Gene

Orthologs for ZC2HC1C Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC2HC1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC2HC1C 34 35
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia ZC2HC1C 34 35
  • 83.7 (n)
cow
(Bos Taurus)
Mammalia FAM164C 34
  • 81.6 (n)
ZC2HC1C 35
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc2hc1c 34
  • 77.28 (n)
mouse
(Mus musculus)
Mammalia Zc2hc1c 34 16 35
  • 75.71 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC2HC1C 35
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
ManyToMany
chicken
(Gallus gallus)
Aves FAM164C 34
  • 51.37 (n)
ZC2HC1C 35
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC2HC1C 35
  • 26 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zc2hc1c 34
  • 54.76 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC799591 34
  • 51.32 (n)
zc2hc1c 35
  • 16 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42675 35
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToOne
Species where no ortholog for ZC2HC1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZC2HC1C Gene

ENSEMBL:
Gene Tree for ZC2HC1C (if available)
TreeFam:
Gene Tree for ZC2HC1C (if available)

Paralogs for ZC2HC1C Gene

Paralogs for ZC2HC1C Gene

genes like me logo Genes that share paralogs with ZC2HC1C: view

Variants for ZC2HC1C Gene

Sequence variations from dbSNP and Humsavar for ZC2HC1C Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000008765 -- 75,076,708(+) TGATA(C/T)GGTCT intron-variant
rs1000060993 -- 75,077,105(+) AAGAT(C/T)AACCC intron-variant
rs1000300669 -- 75,074,258(+) TTGCC(C/T)TCTTG intron-variant
rs1000336708 -- 75,070,589(+) TCCAG(C/T)GGTTG intron-variant, upstream-variant-2KB, reference, missense
rs1000686640 -- 75,078,954(+) AATCA(C/G)AGAAC nc-transcript-variant, utr-variant-3-prime

Variation tolerance for ZC2HC1C Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC2HC1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC2HC1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZC2HC1C Gene

Disorders for ZC2HC1C Gene

Relevant External Links for ZC2HC1C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC2HC1C

No disorders were found for ZC2HC1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC2HC1C Gene

Publications for ZC2HC1C Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3 64

Products for ZC2HC1C Gene

Sources for ZC2HC1C Gene

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