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Aliases for ZC2HC1B Gene

Aliases for ZC2HC1B Gene

  • Zinc Finger C2HC-Type Containing 1B 2 3 5
  • Family With Sequence Similarity 164, Member B 2 3
  • C6orf94 3 4
  • FAM164B 3 4
  • Zinc Finger C2HC Domain-Containing Protein 1B 3
  • Chromosome 6 Open Reading Frame 94 2
  • Protein FAM164B 3
  • DJ468K18.5 3

External Ids for ZC2HC1B Gene

Previous HGNC Symbols for ZC2HC1B Gene

  • FAM164B
  • C6orf94

Previous GeneCards Identifiers for ZC2HC1B Gene

  • GC06P144186

Summaries for ZC2HC1B Gene

GeneCards Summary for ZC2HC1B Gene

ZC2HC1B (Zinc Finger C2HC-Type Containing 1B) is a Protein Coding gene. Diseases associated with ZC2HC1B include Diabetes Mellitus, Transient Neonatal, 1. An important paralog of this gene is ZC2HC1A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC2HC1B Gene

Genomics for ZC2HC1B Gene

Regulatory Elements for ZC2HC1B Gene

Enhancers for ZC2HC1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G143807 1.6 FANTOM5 Ensembl ENCODE 10.8 -56.4 -56436 0.8 HDGF PKNOX1 ATF1 CREB3L1 ARNT YY1 TCF12 ZNF766 CBX5 ELK1 ZC2HC1B STX11 PLAGL1 ENSG00000257065 LTV1
GH06G143802 1.6 FANTOM5 Ensembl ENCODE 10.8 -59.6 -59580 4.7 HDGF PKNOX1 CREB3L1 ARNT ZNF766 FOS KLF13 JUNB REST TBX21 ZC2HC1B LTV1 PHACTR2 PLAGL1 ENSG00000257065 GC06P143756
GH06G143741 1.7 Ensembl ENCODE dbSUPER 9.8 -118.7 -118687 9.5 MLX CREB3L1 AGO1 FEZF1 DMAP1 SP3 NFYC TBX21 SSRP1 ZNF610 VDAC1P8 LTV1 ENSG00000270890 PHACTR2 PHACTR2-AS1 TUBB8P2 ZC2HC1B GC06P143748 GC06P143711
GH06G143895 1.4 ENCODE dbSUPER 11.3 +31.7 31680 1.3 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 SLC30A9 LTV1 TUBB8P2 ZC2HC1B PHACTR2 GC06P143999
GH06G143691 1.5 Ensembl ENCODE dbSUPER 10.5 -171.7 -171664 2.9 HNRNPUL1 PKNOX1 FOXA2 ARNT MLX ARID4B ZNF2 SLC30A9 GATA2 ZNF548 LTV1 VDAC1P8 ENSG00000270890 ZC2HC1B GC06M143473 GC06P143680
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC2HC1B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC2HC1B Gene

Chromosome:
6
Start:
143,864,436 bp from pter
End:
143,938,356 bp from pter
Size:
73,921 bases
Orientation:
Plus strand

Genomic View for ZC2HC1B Gene

Genes around ZC2HC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC2HC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC2HC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC2HC1B Gene

Proteins for ZC2HC1B Gene

  • Protein details for ZC2HC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TFG8-ZC21B_HUMAN
    Recommended name:
    Zinc finger C2HC domain-containing protein 1B
    Protein Accession:
    Q5TFG8
    Secondary Accessions:
    • B2RUZ7
    • Q5TFG9

    Protein attributes for ZC2HC1B Gene

    Size:
    222 amino acids
    Molecular mass:
    24665 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI21444.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21445.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZC2HC1B Gene

Post-translational modifications for ZC2HC1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC2HC1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZC2HC1B Gene

Domains & Families for ZC2HC1B Gene

Gene Families for ZC2HC1B Gene

Protein Domains for ZC2HC1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC2HC1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TFG8

UniProtKB/Swiss-Prot:

ZC21B_HUMAN :
  • Belongs to the ZC2HC1 family.
Family:
  • Belongs to the ZC2HC1 family.
genes like me logo Genes that share domains with ZC2HC1B: view

Function for ZC2HC1B Gene

Gene Ontology (GO) - Molecular Function for ZC2HC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC2HC1B: view

Phenotypes for ZC2HC1B Gene

genes like me logo Genes that share phenotypes with ZC2HC1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZC2HC1B Gene

Localization for ZC2HC1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC2HC1B gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZC2HC1B Gene

Pathways & Interactions for ZC2HC1B Gene

SuperPathways for ZC2HC1B Gene

No Data Available

Interacting Proteins for ZC2HC1B Gene

Selected Interacting proteins: Q5TFG8-ZC21B_HUMAN for ZC2HC1B Gene via IID

Symbol External ID(s) Details
YWHAE

Gene Ontology (GO) - Biological Process for ZC2HC1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZC2HC1B Gene

Drugs & Compounds for ZC2HC1B Gene

No Compound Related Data Available

Transcripts for ZC2HC1B Gene

mRNA/cDNA for ZC2HC1B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZC2HC1B Gene

Zinc finger, C2HC-type containing 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC2HC1B Gene

No ASD Table

Relevant External Links for ZC2HC1B Gene

GeneLoc Exon Structure for
ZC2HC1B
ECgene alternative splicing isoforms for
ZC2HC1B

Expression for ZC2HC1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC2HC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZC2HC1B Gene

This gene is overexpressed in Testis (x43.0).

Protein differential expression in normal tissues from HIPED for ZC2HC1B Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZC2HC1B Gene



Protein tissue co-expression partners for ZC2HC1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC2HC1B Gene:

ZC2HC1B

SOURCE GeneReport for Unigene cluster for ZC2HC1B Gene:

Hs.121188
genes like me logo Genes that share expression patterns with ZC2HC1B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC2HC1B Gene

Orthologs for ZC2HC1B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC2HC1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC2HC1B 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia ZC2HC1B 34 35
  • 87 (n)
cow
(Bos Taurus)
Mammalia ZC2HC1B 34 35
  • 86.76 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC2HC1B 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc2hc1b 34 16 35
  • 79.84 (n)
rat
(Rattus norvegicus)
Mammalia Zc2hc1b 34
  • 79.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZC2HC1B 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H6ORF94 34
  • 67.7 (n)
ZC2HC1B 35
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T03G11.3 34 35
  • 52.04 (n)
Species where no ortholog for ZC2HC1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZC2HC1B Gene

ENSEMBL:
Gene Tree for ZC2HC1B (if available)
TreeFam:
Gene Tree for ZC2HC1B (if available)

Paralogs for ZC2HC1B Gene

Paralogs for ZC2HC1B Gene

(2) SIMAP similar genes for ZC2HC1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZC2HC1B: view

Variants for ZC2HC1B Gene

Sequence variations from dbSNP and Humsavar for ZC2HC1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000012741 -- 143,913,438(+) GATGG(C/T)TTACT intron-variant
rs1000019628 -- 143,916,933(+) ACTTT(A/G)GGGGA intron-variant
rs1000080719 -- 143,925,974(+) CCCTT(G/T)TTGTT intron-variant
rs1000083456 -- 143,880,718(+) TGAGC(A/G)TGGCT intron-variant
rs1000119260 -- 143,927,045(+) CACCC(A/G)CCTCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC2HC1B Gene

Variant ID Type Subtype PubMed ID
dgv10957n54 CNV loss 21841781
dgv10958n54 CNV loss 21841781
dgv10959n54 CNV loss 21841781
dgv10960n54 CNV loss 21841781
dgv1159e199 CNV deletion 23128226
esv24458 CNV loss 19812545
esv3540585 CNV deletion 23714750
esv3611102 CNV loss 21293372
nsv1072699 CNV deletion 25765185
nsv1114877 CNV deletion 24896259
nsv5515 CNV insertion 18451855
nsv604814 CNV loss 21841781
nsv830830 CNV gain 17160897

Variation tolerance for ZC2HC1B Gene

Gene Damage Index Score: 2.58; 44.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC2HC1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC2HC1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC2HC1B Gene

Disorders for ZC2HC1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZC2HC1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, transient neonatal, 1
  • diabetes mellitus, transient neonatal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZC2HC1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC2HC1B
genes like me logo Genes that share disorders with ZC2HC1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZC2HC1B Gene

Publications for ZC2HC1B Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZC2HC1B Gene

Sources for ZC2HC1B Gene

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