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Aliases for ZC2HC1A Gene

Aliases for ZC2HC1A Gene

  • Zinc Finger C2HC-Type Containing 1A 2 3
  • Family With Sequence Similarity 164, Member A 2 3
  • Zinc Finger, C2HC-Type Containing 1A 3 5
  • C8orf70 3 4
  • FAM164A 3 4
  • Chromosome 8 Open Reading Frame 70 2
  • Protein FAM164A 3
  • CGI-62 3

External Ids for ZC2HC1A Gene

Previous HGNC Symbols for ZC2HC1A Gene

  • C8orf70
  • FAM164A

Previous GeneCards Identifiers for ZC2HC1A Gene

  • GC08P079579

Summaries for ZC2HC1A Gene

GeneCards Summary for ZC2HC1A Gene

ZC2HC1A (Zinc Finger C2HC-Type Containing 1A) is a Protein Coding gene. An important paralog of this gene is ZC2HC1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC2HC1A Gene

Genomics for ZC2HC1A Gene

Regulatory Elements for ZC2HC1A Gene

Promoters for ZC2HC1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZC2HC1A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZC2HC1A Gene

Chromosome:
8
Start:
78,666,047 bp from pter
End:
78,719,765 bp from pter
Size:
53,719 bases
Orientation:
Plus strand

Genomic View for ZC2HC1A Gene

Genes around ZC2HC1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC2HC1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC2HC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC2HC1A Gene

Proteins for ZC2HC1A Gene

  • Protein details for ZC2HC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GY0-ZC21A_HUMAN
    Recommended name:
    Zinc finger C2HC domain-containing protein 1A
    Protein Accession:
    Q96GY0
    Secondary Accessions:
    • Q9Y372

    Protein attributes for ZC2HC1A Gene

    Size:
    325 amino acids
    Molecular mass:
    35092 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZC2HC1A Gene

Proteomics data for ZC2HC1A Gene at MOPED

Post-translational modifications for ZC2HC1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC2HC1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZC2HC1A Gene

Domains & Families for ZC2HC1A Gene

Gene Families for ZC2HC1A Gene

Protein Domains for ZC2HC1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC2HC1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GY0

UniProtKB/Swiss-Prot:

ZC21A_HUMAN :
  • Belongs to the ZC2HC1 family.
  • Contains 1 C2HC-type zinc finger.
Family:
  • Belongs to the ZC2HC1 family.
Similarity:
  • Contains 1 C2HC-type zinc finger.
genes like me logo Genes that share domains with ZC2HC1A: view

Function for ZC2HC1A Gene

Gene Ontology (GO) - Molecular Function for ZC2HC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZC2HC1A: view

Phenotypes for ZC2HC1A Gene

genes like me logo Genes that share phenotypes with ZC2HC1A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC2HC1A Gene

Localization for ZC2HC1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZC2HC1A Gene COMPARTMENTS Subcellular localization image for ZC2HC1A gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZC2HC1A Gene

Pathways & Interactions for ZC2HC1A Gene

SuperPathways for ZC2HC1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC2HC1A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZC2HC1A Gene

Drugs & Compounds for ZC2HC1A Gene

No Compound Related Data Available

Transcripts for ZC2HC1A Gene

Unigene Clusters for ZC2HC1A Gene

Zinc finger, C2HC-type containing 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZC2HC1A Gene

No ASD Table

Relevant External Links for ZC2HC1A Gene

GeneLoc Exon Structure for
ZC2HC1A
ECgene alternative splicing isoforms for
ZC2HC1A

Expression for ZC2HC1A Gene

mRNA expression in normal human tissues for ZC2HC1A Gene

Protein differential expression in normal tissues from HIPED for ZC2HC1A Gene

This gene is overexpressed in Frontal cortex (23.9) and Fetal Brain (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZC2HC1A Gene



SOURCE GeneReport for Unigene cluster for ZC2HC1A Gene Hs.271876

genes like me logo Genes that share expression patterns with ZC2HC1A: view

Protein tissue co-expression partners for ZC2HC1A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZC2HC1A Gene

Orthologs for ZC2HC1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC2HC1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC2HC1A 35
  • 100 (n)
  • 100 (a)
ZC2HC1A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZC2HC1A 36
  • 91 (a)
OneToOne
ZC2HC1A 35
  • 89.89 (n)
  • 91.02 (a)
dog
(Canis familiaris)
Mammalia ZC2HC1A 35
  • 92.39 (n)
  • 92.9 (a)
ZC2HC1A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zc2hc1a 36
  • 87 (a)
OneToOne
Zc2hc1a 16
Zc2hc1a 35
  • 84.47 (n)
  • 87.35 (a)
oppossum
(Monodelphis domestica)
Mammalia ZC2HC1A 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC2HC1A 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zc2hc1a 35
  • 85.91 (n)
  • 87.04 (a)
chicken
(Gallus gallus)
Aves ZC2HC1A 36
  • 61 (a)
OneToOne
FAM164A 35
  • 74.3 (n)
  • 75.16 (a)
lizard
(Anolis carolinensis)
Reptilia ZC2HC1A 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15440 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zc2hc1a 35
  • 67.09 (n)
  • 68.57 (a)
zebrafish
(Danio rerio)
Actinopterygii zc2hc1a 36
  • 57 (a)
OneToOne
wufc28a05 35
zc2hc1a 35
  • 59.29 (n)
  • 60.9 (a)
worm
(Caenorhabditis elegans)
Secernentea T03G11.3 36
  • 25 (a)
OneToMany
Species with no ortholog for ZC2HC1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZC2HC1A Gene

ENSEMBL:
Gene Tree for ZC2HC1A (if available)
TreeFam:
Gene Tree for ZC2HC1A (if available)

Paralogs for ZC2HC1A Gene

Paralogs for ZC2HC1A Gene

(1) SIMAP similar genes for ZC2HC1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZC2HC1A: view

Variants for ZC2HC1A Gene

Sequence variations from dbSNP and Humsavar for ZC2HC1A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_031102 -
rs10087223 -- 78,674,617(+) ACTGC(C/T)ACTAC intron-variant
rs11779153 -- 78,672,794(+) TCAAA(A/T)TACAG intron-variant
rs12682555 -- 78,671,053(+) TACCA(C/G)CAGTG intron-variant
rs13269243 -- 78,669,501(+) AGGAG(C/T)GAAGG intron-variant

Variation tolerance for ZC2HC1A Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC2HC1A Gene

HapMap Linkage Disequilibrium report
ZC2HC1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZC2HC1A Gene

Disorders for ZC2HC1A Gene

Relevant External Links for ZC2HC1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC2HC1A

No disorders were found for ZC2HC1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC2HC1A Gene

Publications for ZC2HC1A Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZC2HC1A Gene

Sources for ZC2HC1A Gene

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