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Aliases for ZC2HC1A Gene

Aliases for ZC2HC1A Gene

  • Zinc Finger C2HC-Type Containing 1A 2 3 5
  • Family With Sequence Similarity 164, Member A 2 3
  • C8orf70 3 4
  • FAM164A 3 4
  • Zinc Finger C2HC Domain-Containing Protein 1A 3
  • Chromosome 8 Open Reading Frame 70 2
  • Protein FAM164A 3
  • CGI-62 3

External Ids for ZC2HC1A Gene

Previous HGNC Symbols for ZC2HC1A Gene

  • C8orf70
  • FAM164A

Previous GeneCards Identifiers for ZC2HC1A Gene

  • GC08P079579

Summaries for ZC2HC1A Gene

GeneCards Summary for ZC2HC1A Gene

ZC2HC1A (Zinc Finger C2HC-Type Containing 1A) is a Protein Coding gene. An important paralog of this gene is ZC2HC1B.

Additional gene information for ZC2HC1A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC2HC1A Gene

Genomics for ZC2HC1A Gene

Regulatory Elements for ZC2HC1A Gene

Enhancers for ZC2HC1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H078508 1 Ensembl ENCODE dbSUPER 10.6 -157.8 -157757 0 CTCF JUND FOXA2 FOS ZC2HC1A IL7 PKIA GC08M078438
GH08H078507 0.9 ENCODE dbSUPER 10.6 -158.3 -158252 0 CTCF ZNF654 ZNF362 TRIM22 ZNF384 REST RAD21 ZNF143 SMC3 ZC2HC1A IL7 PKIA GC08M078438
GH08H078615 0.5 ENCODE 10.9 -50.5 -50527 0 ZNF217 CTCF GATA3 SMC3 RAD21 ZC2HC1A ENSG00000260398 GC08M078638
GH08H078683 0.4 ENCODE 11 +17.6 17584 0 ZNF585B ZC2HC1A GC08M078610
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC2HC1A on UCSC Golden Path with GeneCards custom track

Promoters for ZC2HC1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZC2HC1A Gene

78,666,047 bp from pter
78,719,765 bp from pter
53,719 bases
Plus strand

Genomic View for ZC2HC1A Gene

Genes around ZC2HC1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC2HC1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC2HC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC2HC1A Gene

Proteins for ZC2HC1A Gene

  • Protein details for ZC2HC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger C2HC domain-containing protein 1A
    Protein Accession:
    Secondary Accessions:
    • Q9Y372

    Protein attributes for ZC2HC1A Gene

    325 amino acids
    Molecular mass:
    35092 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZC2HC1A Gene

Post-translational modifications for ZC2HC1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC2HC1A Gene

No data available for DME Specific Peptides for ZC2HC1A Gene

Domains & Families for ZC2HC1A Gene

Gene Families for ZC2HC1A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZC2HC1A Gene


Suggested Antigen Peptide Sequences for ZC2HC1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZC2HC1 family.
  • Belongs to the ZC2HC1 family.
genes like me logo Genes that share domains with ZC2HC1A: view

Function for ZC2HC1A Gene

Gene Ontology (GO) - Molecular Function for ZC2HC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC2HC1A: view

Phenotypes for ZC2HC1A Gene

genes like me logo Genes that share phenotypes with ZC2HC1A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZC2HC1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC2HC1A Gene

Localization for ZC2HC1A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC2HC1A gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZC2HC1A Gene

Pathways & Interactions for ZC2HC1A Gene

SuperPathways for ZC2HC1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC2HC1A Gene


No data available for Pathways by source and SIGNOR curated interactions for ZC2HC1A Gene

Drugs & Compounds for ZC2HC1A Gene

No Compound Related Data Available

Transcripts for ZC2HC1A Gene

Unigene Clusters for ZC2HC1A Gene

Zinc finger, C2HC-type containing 1A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZC2HC1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZC2HC1A Gene

No ASD Table

Relevant External Links for ZC2HC1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZC2HC1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC2HC1A Gene

Protein differential expression in normal tissues from HIPED for ZC2HC1A Gene

This gene is overexpressed in Frontal cortex (23.9) and Fetal Brain (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC2HC1A Gene

Protein tissue co-expression partners for ZC2HC1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC2HC1A Gene:


SOURCE GeneReport for Unigene cluster for ZC2HC1A Gene:


Evidence on tissue expression from TISSUES for ZC2HC1A Gene

  • Eye(4.1)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with ZC2HC1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC2HC1A Gene

Orthologs for ZC2HC1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC2HC1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZC2HC1A 33 34
  • 100 (n)
(Canis familiaris)
Mammalia ZC2HC1A 33 34
  • 92.39 (n)
(Bos Taurus)
Mammalia ZC2HC1A 33 34
  • 89.89 (n)
(Rattus norvegicus)
Mammalia Zc2hc1a 33
  • 85.91 (n)
(Mus musculus)
Mammalia Zc2hc1a 33 16 34
  • 84.47 (n)
(Monodelphis domestica)
Mammalia ZC2HC1A 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia ZC2HC1A 34
  • 70 (a)
(Gallus gallus)
Aves FAM164A 33
  • 74.3 (n)
ZC2HC1A 34
  • 61 (a)
(Anolis carolinensis)
Reptilia ZC2HC1A 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zc2hc1a 33
  • 67.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15440 33
(Danio rerio)
Actinopterygii zc2hc1a 33 34
  • 59.29 (n)
wufc28a05 33
(Caenorhabditis elegans)
Secernentea T03G11.3 34
  • 25 (a)
Species where no ortholog for ZC2HC1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZC2HC1A Gene

Gene Tree for ZC2HC1A (if available)
Gene Tree for ZC2HC1A (if available)

Paralogs for ZC2HC1A Gene

Paralogs for ZC2HC1A Gene

(1) SIMAP similar genes for ZC2HC1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZC2HC1A: view

Variants for ZC2HC1A Gene

Sequence variations from dbSNP and Humsavar for ZC2HC1A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000095322 -- 78,709,981(+) GTAAG(C/G/T)CACAC intron-variant, utr-variant-3-prime
rs1000147829 -- 78,709,717(+) GATGA(A/G)CTAAA intron-variant, utr-variant-3-prime
rs1000192960 -- 78,682,348(+) CTGGG(A/T)AATTT intron-variant
rs1000202661 -- 78,714,129(+) TTTAA(A/G)GATTT intron-variant
rs1000264177 -- 78,716,996(+) TACAG(C/T)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC2HC1A Gene

Variant ID Type Subtype PubMed ID
dgv3850n106 CNV deletion 24896259
esv2759622 CNV loss 17122850
esv3617738 CNV loss 21293372
esv3617740 CNV loss 21293372
esv3891420 CNV loss 25118596
nsv397013 CNV deletion 16902084

Variation tolerance for ZC2HC1A Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC2HC1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC2HC1A Gene

Disorders for ZC2HC1A Gene

Relevant External Links for ZC2HC1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZC2HC1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC2HC1A Gene

Publications for ZC2HC1A Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 60
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 60

Products for ZC2HC1A Gene

Sources for ZC2HC1A Gene

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