ZC2HC1A Gene
protein-coding GIFtS: 40
GCID: GC08P079579
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zinc finger, C2HC-type containing 1A(Previous names: chromosome 8 open reading frame 70, family with sequence...)
(Previous symbols: C8orf70, FAM164A)
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Aliases
for ZC2HC1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, C2HC-Type Containing 1A1 2 | | CGI-621 | | C8orf701 2 3 | | Chromosome 8 Open Reading Frame 701 | | FAM164A1 2 3 | | Protein FAM164A2 | | Family With Sequence Similarity 164, Member A1 2 | | Zinc Finger C2HC Domain-Containing Protein 1A2 |
Export aliases for ZC2HC1A gene to outside databases |
Summaries
for ZC2HC1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZC2HC1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZC2HC1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZC2HC1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC2HC1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.12 Ensembl cytogenetic band: 8q21.12 HGNC cytogenetic band: 8q21.11ZC2HC1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P079579: view genomic region
(about GC identifiers)
Start:
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79,578,282 bp from pter |
End:
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79,632,000 bp from pter |
Size:
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53,719 bases |
Orientation:
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plus strand |
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Proteins
for ZC2HC1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZC21A_HUMAN, Q96GY0 (See
protein sequence)Recommended Name: Zinc finger C2HC domain-containing protein 1A Size: 325 amino acids; 35092 Da
Secondary accessions: Q9Y372Explore the universe of human proteins at neXtProt for ZC2HC1A: NX_Q96GY0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96GY0
ZC2HC1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057094.2
ENSEMBL proteins: ENSP00000263849 ENSP00000427797
Human Recombinant Protein Products:
ZC2HC1A Antibody Products:
Assay Products for ZC2HC1A: |
Protein
Domains /
Families
for ZC2HC1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZC2HC1A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96GY0ProtoNet protein and cluster: Q96GY0 UniProtKB/Swiss-Prot: ZC21A_HUMAN, Q96GY0Similarity: Belongs to the ZC2HC1 familySimilarity: Contains 1 C2HC-type zinc finger |
Function
for ZC2HC1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC2HC1A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC2HC1A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC2HC1A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
ZC2HC1A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZC2HC1A:
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Pathways & Interactions
for ZC2HC1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC2HC1A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for ZC2HC1A (Q96GY03 ENSP000002638494) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZC2HC1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZC2HC1A
Search CenterWatch for drugs/clinical trials and news about ZC2HC1A / ZC21A
|
Transcripts
for ZC2HC1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZC2HC1A gene: NM_016010.2 Unigene Cluster for ZC2HC1A: Zinc finger, C2HC-type containing 1A Hs.271876 [show with all ESTs]Unigene Representative Sequence: NM_0160104 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263849(uc003ybd.3) ENST00000521873 ENST00000521176 ENST00000519307
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZC2HC1A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZC2HC1A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for ZC2HC1A | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZC2HC1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC2HC1A |
Additional cDNA sequence: AF151820.1 AK024711.1 AK094296.1 AK313723.1 BC009074.1 8 DOTS entries: DT.444194 DT.438177 DT.120632330 DT.120632335 DT.40252895 DT.91740045 DT.314042 DT.40234027 24/96 AceView cDNA sequences (see all 96): BQ011709 AI268579 CB069864 BC035905 BF110373 BU075578 AA283041 N57030 AW104558 AA393755 BU952036 AU098372 BQ012241 AA648813 BM668265 AA766118 AA746032 CD707426 CB958607 CB988508 AI339000 AI268999 AA846854 BU952298
GeneLoc Exon Structure
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Expression
for ZC2HC1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZC2HC1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCATAAAA
About this image
See ZC2HC1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZC2HC1A
SOURCE GeneReport for Unigene cluster: Hs.271876
SABiosciences Custom PCR Arrays for ZC2HC1A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZC2HC1A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ZC2HC1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC2HC1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC2HC1A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC2HC1A |
Orthologs
for ZC2HC1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZC2HC1A gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Zc2hc1a5
Fam164a1 |
family with sequence similarity 164, member A1, 5 |
84.47(n)1
87.35(a)1 |
|
3 (2.01 cM)5
673061 NM_173181.31 NP_775273.11
75034265 |
chicken
(Gallus gallus) |
Aves |
ZC2HC1A1 |
zinc finger, C2HC-type containing 1A |
74.43(n)
75.4(a) |
|
769604 XM_001232350.2 XP_001232351.2 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM164A6 |
-- |
74(a) |
1 ↔ 1 |
4(25420423-25426954) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.154402 |
Xenopus laevis transcribed sequence with weak similarity more |
79.38(n) |
|
BJ079815.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc28a052 |
wufc28a05 |
75.89(n) |
|
324412 BC055250.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
T03G11.36 |
UPF0418 protein T03G11.3 |
25(a) |
1 ↔ 1 |
X(5174338-5177475) |
ENSEMBL Gene Tree for ZC2HC1A (if available)
TreeFam Gene Tree for ZC2HC1A (if available) |
Paralogs
for ZC2HC1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZC2HC1A gene
- ZC2HC1B2 ZC2HC1C2
1 SIMAP similar gene for ZC2HC1A using alignment to 2 protein entries: ZC21A_HUMAN (see all proteins):ZC2HC1B
ZC2HC1A for paralogs About GeneDecksing
|
Genomic Variants
for ZC2HC1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZC2HC1A (79578282 - 79632000 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZC2HC1A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC2HC1A |
|
Disorders
/ Diseases
for ZC2HC1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZC2HC1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZC2HC1A gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZC2HC1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1 Beausoleil S.A.... Gygi S.P. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
|
External Searches for ZC2HC1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZC2HC1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZC2HC1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZC2HC1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZC2HC1A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZC2HC1A gene:
Search GeneIP for patents involving ZC2HC1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZC2HC1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZC2HC1A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZC2HC1A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC2HC1A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZC2HC1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC2HC1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC2HC1A |
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| |  |  |  |  | | | | |
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 | | | ZC2HC1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC2HC1A |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZC2HC1A |
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