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Aliases for ZC2HC1A Gene

Aliases for ZC2HC1A Gene

  • Zinc Finger C2HC-Type Containing 1A 2 3 5
  • Family With Sequence Similarity 164, Member A 2 3
  • C8orf70 3 4
  • FAM164A 3 4
  • Zinc Finger C2HC Domain-Containing Protein 1A 3
  • Chromosome 8 Open Reading Frame 70 2
  • Protein FAM164A 3
  • CGI-62 3

External Ids for ZC2HC1A Gene

Previous HGNC Symbols for ZC2HC1A Gene

  • C8orf70
  • FAM164A

Previous GeneCards Identifiers for ZC2HC1A Gene

  • GC08P079579

Summaries for ZC2HC1A Gene

GeneCards Summary for ZC2HC1A Gene

ZC2HC1A (Zinc Finger C2HC-Type Containing 1A) is a Protein Coding gene. An important paralog of this gene is ZC2HC1B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZC2HC1A Gene

Genomics for ZC2HC1A Gene

Regulatory Elements for ZC2HC1A Gene

Enhancers for ZC2HC1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G078515 1.3 ENCODE dbSUPER 9.7 -149.5 -149479 2.8 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF48 GLIS2 GATA2 ZNF207 ZC2HC1A PKIA PKIA-AS1
GH08G078508 1.1 Ensembl ENCODE dbSUPER 10.6 -157.8 -157757 0.4 JUND FOXA2 CREB1 FOS RELB EP300 ZC2HC1A IL7 PKIA GC08M078438
GH08G078507 0.9 ENCODE dbSUPER 10.6 -158.3 -158252 0.0 CTCF ZNF654 ZNF362 TRIM22 ZNF384 REST RAD21 SMC3 ZNF143 RELB ZC2HC1A IL7 PKIA GC08M078438
GH08G078615 0.5 ENCODE 10.9 -50.5 -50527 0.0 CTCF GATA3 CREB1 SMC3 RAD21 ZC2HC1A ENSG00000260398 GC08M078638
GH08G078664 1.3 FANTOM5 ENCODE 2.5 +0.0 12 2.7 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 GATA2 ENSG00000254352 ZC2HC1A IL7 GC08M078610
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZC2HC1A on UCSC Golden Path with GeneCards custom track

Promoters for ZC2HC1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000226120 253 1801 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 GATA2

Genomic Location for ZC2HC1A Gene

Chromosome:
8
Start:
78,666,047 bp from pter
End:
78,719,765 bp from pter
Size:
53,719 bases
Orientation:
Plus strand

Genomic View for ZC2HC1A Gene

Genes around ZC2HC1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZC2HC1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZC2HC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZC2HC1A Gene

Proteins for ZC2HC1A Gene

  • Protein details for ZC2HC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GY0-ZC21A_HUMAN
    Recommended name:
    Zinc finger C2HC domain-containing protein 1A
    Protein Accession:
    Q96GY0
    Secondary Accessions:
    • Q9Y372

    Protein attributes for ZC2HC1A Gene

    Size:
    325 amino acids
    Molecular mass:
    35092 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZC2HC1A Gene

Post-translational modifications for ZC2HC1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZC2HC1A Gene

No data available for DME Specific Peptides for ZC2HC1A Gene

Domains & Families for ZC2HC1A Gene

Gene Families for ZC2HC1A Gene

Protein Domains for ZC2HC1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZC2HC1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GY0

UniProtKB/Swiss-Prot:

ZC21A_HUMAN :
  • Belongs to the ZC2HC1 family.
Family:
  • Belongs to the ZC2HC1 family.
genes like me logo Genes that share domains with ZC2HC1A: view

Function for ZC2HC1A Gene

Gene Ontology (GO) - Molecular Function for ZC2HC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZC2HC1A: view

Phenotypes for ZC2HC1A Gene

genes like me logo Genes that share phenotypes with ZC2HC1A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZC2HC1A Gene

Localization for ZC2HC1A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZC2HC1A gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZC2HC1A Gene

Pathways & Interactions for ZC2HC1A Gene

SuperPathways for ZC2HC1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZC2HC1A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZC2HC1A Gene

Transcripts for ZC2HC1A Gene

Unigene Clusters for ZC2HC1A Gene

Zinc finger, C2HC-type containing 1A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZC2HC1A Gene

No ASD Table

Relevant External Links for ZC2HC1A Gene

GeneLoc Exon Structure for
ZC2HC1A
ECgene alternative splicing isoforms for
ZC2HC1A

Expression for ZC2HC1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZC2HC1A Gene

Protein differential expression in normal tissues from HIPED for ZC2HC1A Gene

This gene is overexpressed in Frontal cortex (23.9) and Fetal Brain (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZC2HC1A Gene



Protein tissue co-expression partners for ZC2HC1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZC2HC1A Gene:

ZC2HC1A

SOURCE GeneReport for Unigene cluster for ZC2HC1A Gene:

Hs.271876

Evidence on tissue expression from TISSUES for ZC2HC1A Gene

  • Eye(4.1)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with ZC2HC1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZC2HC1A Gene

Orthologs for ZC2HC1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZC2HC1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZC2HC1A 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia ZC2HC1A 34 35
  • 92.39 (n)
cow
(Bos Taurus)
Mammalia ZC2HC1A 34 35
  • 89.89 (n)
rat
(Rattus norvegicus)
Mammalia Zc2hc1a 34
  • 85.91 (n)
mouse
(Mus musculus)
Mammalia Zc2hc1a 34 16 35
  • 84.47 (n)
oppossum
(Monodelphis domestica)
Mammalia ZC2HC1A 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZC2HC1A 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM164A 34
  • 74.3 (n)
ZC2HC1A 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZC2HC1A 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zc2hc1a 34
  • 67.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15440 34
zebrafish
(Danio rerio)
Actinopterygii zc2hc1a 34 35
  • 59.29 (n)
wufc28a05 34
worm
(Caenorhabditis elegans)
Secernentea T03G11.3 35
  • 25 (a)
OneToMany
Species where no ortholog for ZC2HC1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZC2HC1A Gene

ENSEMBL:
Gene Tree for ZC2HC1A (if available)
TreeFam:
Gene Tree for ZC2HC1A (if available)

Paralogs for ZC2HC1A Gene

Paralogs for ZC2HC1A Gene

(1) SIMAP similar genes for ZC2HC1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZC2HC1A: view

Variants for ZC2HC1A Gene

Sequence variations from dbSNP and Humsavar for ZC2HC1A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000095322 -- 78,709,981(+) GTAAG(C/G/T)CACAC intron-variant, utr-variant-3-prime
rs1000147829 -- 78,709,717(+) GATGA(A/G)CTAAA intron-variant, utr-variant-3-prime
rs1000192960 -- 78,682,348(+) CTGGG(A/T)AATTT intron-variant
rs1000202661 -- 78,714,129(+) TTTAA(A/G)GATTT intron-variant
rs1000264177 -- 78,716,996(+) TACAG(C/T)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZC2HC1A Gene

Variant ID Type Subtype PubMed ID
dgv3850n106 CNV deletion 24896259
esv2759622 CNV loss 17122850
esv3617738 CNV loss 21293372
esv3617740 CNV loss 21293372
esv3891420 CNV loss 25118596
nsv397013 CNV deletion 16902084

Variation tolerance for ZC2HC1A Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZC2HC1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZC2HC1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZC2HC1A Gene

Disorders for ZC2HC1A Gene

Relevant External Links for ZC2HC1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZC2HC1A

No disorders were found for ZC2HC1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZC2HC1A Gene

Publications for ZC2HC1A Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for ZC2HC1A Gene

Sources for ZC2HC1A Gene

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