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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZC2HC1A Gene

protein-coding   GIFtS: 42
GCID: GC08P079579

Zinc Finger, C2HC-Type Containing 1A

(Previous names: chromosome 8 open reading frame 70, family with sequence...)
(Previous symbols: C8orf70, FAM164A)
  Search for ZC2HC1A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, C2HC-Type Containing 1A1 2     Chromosome 8 Open Reading Frame 701
C8orf701 2 3     Protein FAM164A2
FAM164A1 2 3     Zinc Finger C2HC Domain-Containing Protein 1A2
Family With Sequence Similarity 164, Member A1 2     

External Ids:    HGNC: 242771   Entrez Gene: 511012   Ensembl: ENSG000001044277   UniProtKB: Q96GY03   

Export aliases for ZC2HC1A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZC2HC1A Gene: 
ZC2HC1A (zinc finger, C2HC-type containing 1A) is a protein-coding gene. GO annotations related to this gene include metal ion binding. An important paralog of this gene is ZC2HC1B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZC2HC1A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZC2HC1A promoter sequence
   Search SABiosciences Chromatin IP Primers for ZC2HC1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZC2HC1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.12   Ensembl cytogenetic band:  8q21.12   HGNC cytogenetic band: 8q21.11

ZC2HC1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC2HC1A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P079579:  view genomic region     (about GC identifiers)

Start:
79,578,282 bp from pter      End:
79,632,000 bp from pter
Size:
53,719 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZC21A_HUMAN, Q96GY0 (See protein sequence)
Recommended Name: Zinc finger C2HC domain-containing protein 1A  
Size: 325 amino acids; 35092 Da
Secondary accessions: Q9Y372

Explore the universe of human proteins at neXtProt for ZC2HC1A: NX_Q96GY0

Explore proteomics data for ZC2HC1A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96GY0

  • ZC2HC1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZC2HC1A Protein Expression
    REFSEQ proteins: NP_057094.2  
    ENSEMBL proteins: 
     ENSP00000263849   ENSP00000427797  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC2HC: Zinc fingers, C2HC-type containing

    1 InterPro protein domain:
     IPR026319 ZC2HC1

    Graphical View of Domain Structure for InterPro Entry Q96GY0

    ProtoNet protein and cluster: Q96GY0

    UniProtKB/Swiss-Prot: ZC21A_HUMAN, Q96GY0
    Similarity: Belongs to the ZC2HC1 family
    Similarity: Contains 1 C2HC-type zinc finger


    ZC2HC1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    ZC2HC1A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZC2HC1A:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZC2HC1A 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC2HC1A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for ZC2HC1A (Q96GY03 ENSP000002638494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAM2O153943I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZC2HC1A (ZC21A)

    Search CenterWatch for drugs/clinical trials and news about ZC2HC1A / ZC21A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZC2HC1A gene: 
    NM_016010.2  

    Unigene Cluster for ZC2HC1A:

    Zinc finger, C2HC-type containing 1A
    Hs.271876  [show with all ESTs]
    Unigene Representative Sequence: NM_016010
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263849(uc003ybd.3) ENST00000521873 ENST00000521176 ENST00000519307

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZC2HC1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZC2HC1A
    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of ZC2HC1A 
    Primer
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    OriGene qPCR primer pairs and template standards for ZC2HC1A
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZC2HC1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZC2HC1A

    Additional mRNA sequence: 

    AF151820.1 AK024711.1 AK094296.1 AK313723.1 BC009074.1 

    8 DOTS entries:

    DT.444194  DT.438177  DT.120632330  DT.120632335  DT.40252895  DT.91740045  DT.314042  DT.40234027 

    24/96 AceView cDNA sequences (see all 96):

    AW104558 BU952036 BU075578 BC035905 BM668265 BQ011709 BF110373 AI268579 
    AA648813 CB069864 N57030 BQ012241 AU098372 AA283041 AA766118 AA393755 
    AI192620 BU075773 NM_016010 BF996756 AA780122 AI339000 BI600862 W87505 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZC2HC1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCATAAAA
    ZC2HC1A Expression
    About this image


    See ZC2HC1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZC2HC1A

    SOURCE GeneReport for Unigene cluster: Hs.271876
        SABiosciences Custom PCR Arrays for ZC2HC1A
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    OriGene qPCR primer pairs and template standards for ZC2HC1A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZC2HC1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZC2HC1A gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zc2hc1a5
    Fam164a1
    family with sequence similarity 164, member A1, 5 84.47(n)1
    87.35(a)1
      3 (2.01 cM)5
    673061  NM_173181.31  NP_775273.11 
     75034265 
    chicken
    (Gallus gallus)
    Aves ZC2HC1A1 zinc finger, C2HC-type containing 1A 74.43(n)
    75.4(a)
      769604  XM_001232350.2  XP_001232351.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZC2HC1A6
    zinc finger, C2HC-type containing 1A
    66(a)
    1 ↔ 1
    4(25414014-25451169)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154402 Xenopus laevis transcribed sequence with weak similarity more 79.38(n)    BJ079815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc28a052 wufc28a05 75.89(n)   324412  BC055250.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T03G11.36
    Zinc finger C2HC domain-containing protein T03G11....
    23(a)
    1 → many
    X(5174369-5177506)


    ENSEMBL Gene Tree for ZC2HC1A (if available)
    TreeFam Gene Tree for ZC2HC1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZC2HC1A gene
    ZC2HC1B2  ZC2HC1C2  
    1 SIMAP similar gene for ZC2HC1A using alignment to 2 protein entries:     ZC21A_HUMAN (see all proteins):
    ZC2HC1B

    ZC2HC1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1055 SNPs in ZC2HC1A are shown (see all 1055)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs794263701,2
    C,F--79576314(+) CCAGGG/CTAGCT 1 -- us2k11Minor allele frequency- C:0.11WA 118
    rs1919781101,2
    --79576324(+) TGTAGC/TGTAAA 1 -- us2k10--------
    rs1174248931,2
    F--79576430(+) CCTACT/ACAAAT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1181855471,2
    C,F--79576506(+) CAAGGA/CAAGGG 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1826513921,2
    --79576667(+) AAGATC/TGTAGT 1 -- us2k10--------
    rs1388349381,2
    C--79576669(+) GATTGG/TAGTAT 1 -- us2k10--------
    rs1876504921,2
    --79576756(+) TAATGC/TTATTT 1 -- us2k10--------
    rs169059371,2
    C,F,H--79576796(+) ATGTCG/AAATAA 1 -- us2k19Minor allele frequency- A:0.03NA NS EA CSA WA 678
    rs1916834361,2
    --79577008(+) CAGTCG/TAGAGT 1 -- us2k10--------
    rs1417133301,2
    --79577064(+) TCTCAC/GAGAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZC2HC1A (79578282 - 79632000 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZC2HC1A: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZC2HC1A
    DNA2.0 Custom Variant and Variant Library Synthesis for ZC2HC1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZC2HC1A gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ZC2HC1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1 Beausoleil S.A.... Gygi S.P. (2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51101 HGNC: 24277 AceView: CGI-62 Ensembl:ENSG00000104427 euGenes: HUgn51101
    ECgene: ZC2HC1A H-InvDB: ZC2HC1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZC2HC1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZC2HC1A gene:
    Search GeneIP for patents involving ZC2HC1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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