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Aliases for ZBTB9 Gene

Aliases for ZBTB9 Gene

  • Zinc Finger And BTB Domain Containing 9 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 9 3
  • ZNF919 3

External Ids for ZBTB9 Gene

Previous GeneCards Identifiers for ZBTB9 Gene

  • GC06P033469
  • GC06P033496
  • GC06P033530
  • GC06P033164

Summaries for ZBTB9 Gene

GeneCards Summary for ZBTB9 Gene

ZBTB9 (Zinc Finger And BTB Domain Containing 9) is a Protein Coding gene. An important paralog of this gene is ZBTB22.

UniProtKB/Swiss-Prot for ZBTB9 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB9 Gene

Genomics for ZBTB9 Gene

Regulatory Elements for ZBTB9 Gene

Enhancers for ZBTB9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H033430 1.5 FANTOM5 ENCODE dbSUPER 31.5 -21.6 -21551 4 HDGF ATF1 FOXA2 ARID4B SIN3A GLIS2 ELK1 ZNF143 FOS RUNX3 RING1 HCG25 DAXX ZBTB9 PHF1 RXRB BRD2 LEMD2 SYNGAP1 LOC105375022
GH06H033423 1.7 FANTOM5 ENCODE dbSUPER 11.7 -28.0 -28006 3 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF143 SP3 MXD4 SYNGAP1 DAXX ZBTB9 KIFC1 RPL35AP4 NUDT3 CUTA WDR46 MIR5004
GH06H033428 1.6 FANTOM5 ENCODE dbSUPER 11.7 -24.9 -24860 1 HDGF PKNOX1 ATF1 FOXA2 ZFP64 ARID4B SIN3A YBX1 DMAP1 TCF12 DAXX BRD2 LEMD2 WDR46 VPS52 RXRB ZBTB9 SMIM29 RPL35AP4 KIFC1
GH06H033373 1.2 Ensembl ENCODE 10.4 -78.5 -78496 3 HDGF PKNOX1 ATF1 ZNF2 GTF3C2 ATF7 CAVIN1 NCOA1 REST ZNF592 WDR46 DAXX RGL2 VPS52 BRD2 LEMD2 ITPR3 RXRB PHF1 ZBTB22
GH06H034068 0.9 dbSUPER 9.9 +616.5 616459 4 NFIB ZNF473 ZSCAN4 INSM2 YBX1 PLRG1 ZNF416 ZNF207 ZNF548 ZNF391 TAF11 RING1 HCG25 RXRB LEMD2 VPS52 DAXX WDR46 PHF1 SYNGAP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB9 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195799 330 1801 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS DEK

Genomic Location for ZBTB9 Gene

Chromosome:
6
Start:
33,453,970 bp from pter
End:
33,457,548 bp from pter
Size:
3,579 bases
Orientation:
Plus strand

Genomic View for ZBTB9 Gene

Genes around ZBTB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB9 Gene

Proteins for ZBTB9 Gene

  • Protein details for ZBTB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C00-ZBTB9_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 9
    Protein Accession:
    Q96C00
    Secondary Accessions:
    • A2AB19

    Protein attributes for ZBTB9 Gene

    Size:
    473 amino acids
    Molecular mass:
    50602 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB9 Gene

Post-translational modifications for ZBTB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB9 Gene

No data available for DME Specific Peptides for ZBTB9 Gene

Domains & Families for ZBTB9 Gene

Gene Families for ZBTB9 Gene

Protein Domains for ZBTB9 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB9: view

No data available for UniProtKB/Swiss-Prot for ZBTB9 Gene

Function for ZBTB9 Gene

Molecular function for ZBTB9 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB9 Gene

Gene Ontology (GO) - Molecular Function for ZBTB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB9: view

Phenotypes for ZBTB9 Gene

GenomeRNAi human phenotypes for ZBTB9:
genes like me logo Genes that share phenotypes with ZBTB9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZBTB9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB9 Gene

Localization for ZBTB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB9 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ZBTB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB9 Gene

Pathways & Interactions for ZBTB9 Gene

SuperPathways for ZBTB9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB9: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB9 Gene

Drugs & Compounds for ZBTB9 Gene

No Compound Related Data Available

Transcripts for ZBTB9 Gene

mRNA/cDNA for ZBTB9 Gene

Unigene Clusters for ZBTB9 Gene

Zinc finger and BTB domain containing 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZBTB9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB9 Gene

No ASD Table

Relevant External Links for ZBTB9 Gene

GeneLoc Exon Structure for
ZBTB9
ECgene alternative splicing isoforms for
ZBTB9

Expression for ZBTB9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB9 Gene

Protein differential expression in normal tissues from HIPED for ZBTB9 Gene

This gene is overexpressed in Monocytes (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB9 Gene



Protein tissue co-expression partners for ZBTB9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB9 Gene:

ZBTB9

SOURCE GeneReport for Unigene cluster for ZBTB9 Gene:

Hs.591805

Evidence on tissue expression from TISSUES for ZBTB9 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with ZBTB9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB9 Gene

Orthologs for ZBTB9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB9 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB9 33 34
  • 86.3 (n)
dog
(Canis familiaris)
Mammalia ZBTB9 33
  • 85.82 (n)
mouse
(Mus musculus)
Mammalia Zbtb9 33 16 34
  • 82.68 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb9 33
  • 81.22 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB9 34
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB9 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb9 33
  • 58.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12662 33
Species where no ortholog for ZBTB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZBTB9 Gene

ENSEMBL:
Gene Tree for ZBTB9 (if available)
TreeFam:
Gene Tree for ZBTB9 (if available)

Paralogs for ZBTB9 Gene

genes like me logo Genes that share paralogs with ZBTB9: view

Variants for ZBTB9 Gene

Sequence variations from dbSNP and Humsavar for ZBTB9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000444373 -- 33,457,486(+) GAATC(-/G)GGGGG utr-variant-3-prime
rs1000643222 -- 33,454,863(+) GTGGT(G/T)GTTGT intron-variant
rs1000878537 -- 33,457,753(+) CTTAC(-/TGTTTTGTTT)TGTTT downstream-variant-500B
rs1001573882 -- 33,457,058(+) AGCCC(C/G)TCAGA utr-variant-3-prime
rs1001884214 -- 33,454,213(+) GTGGG(C/G)AAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZBTB9 Gene

Variant ID Type Subtype PubMed ID
esv3608630 CNV gain 21293372
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv602832 CNV loss 21841781
nsv830637 CNV loss 17160897

Variation tolerance for ZBTB9 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.42; 63.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB9 Gene

Disorders for ZBTB9 Gene

Relevant External Links for ZBTB9

Genetic Association Database (GAD)
ZBTB9
Human Genome Epidemiology (HuGE) Navigator
ZBTB9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB9

No disorders were found for ZBTB9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB9 Gene

Publications for ZBTB9 Gene

  1. Genome-wide association study of smoking behaviours in patients with COPD. (PMID: 21685187) Siedlinski M … ECLIPSE Investigators (Thorax 2011) 3 45 60
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for ZBTB9 Gene

Sources for ZBTB9 Gene

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