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ZBTB9 Gene

protein-coding GIFtS: 46

GC06P033496

zinc finger and BTB domain containing 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC23166 ^¹, ²

Descriptions
zinc finger and BTB domain containing 9 ^²

External Ids
HGNC: 28323¹
Entrez Gene: 221504²
UniProtKB: Q96C00³
Ensembl: ENSG00000213588⁷

Search outside databases for aliases for ZBTB9 gene

Previous GC identifer: GC06P033469

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBTB9_HUMAN, Q96C00

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZBTB9 gene

Entrez Gene cytogenetic band: 6p21.32 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.31

ZBTB9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P033496: (about GC identifiers)

Start:	33,530,334 bp from pter
End:	33,533,299 bp from pter
Size:	2,966 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBTB9_HUMAN, Q96C00 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 9

Size: 473 amino acids; 50602 Da

Subcellular location: Nucleus (Potential)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_689948.1

ENSEMBL proteins:

ENSP00000378503

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Zinc finger and BTB domain-containing protein 9)
	Human Recombinant Proteins from Abnova (ZBTB9)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

About this table

Antibodies for ZBTB9:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBTB9
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Zinc finger and BTB domain-containing protein 9), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZBTB9)
	Novus Biologicals Antibody for ZBTB9

Assays for ZBTB9:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96C00

ProtoNet protein and cluster: Q96C00

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: ZBTB9_HUMAN, Q96C00

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 2 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB9)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152735

Applied Biosystems Silencer® siRNAs for ZBTB9

Sigma-Aldrich siRNA and siRNA Panels for ZBTB9

Sigma-Aldrich shRNA for ZBTB9

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZBTB9
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_152735
Myc/DDK tagged cDNA clone in CMV expression vector: NM_152735
untagged cDNA clone in CMV expression vector: NM_152735

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_152735

UniProtKB/Swiss-Prot: ZBTB9_HUMAN, Q96C00

Function: May be involved in transcriptional regulation

5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0004886	retinoid-X receptor activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0030375	thyroid hormone receptor coactivator activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB9

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB9)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152735

Sigma-Aldrich siRNA and siRNA Panels for ZBTB9

Sigma-Aldrich shRNA for ZBTB9

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_152735

REFSEQ mRNAs for ZBTB9 gene:

NM_152735.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_152735

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152735
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_152735
                                 untagged cDNA clone in CMV expression vector: NM_152735

Additional cDNA sequence:

AK122644.1 AK313571.1 BC014978.1 BC048321.1 CR605806.1

5 DOTS entries:

DT.313158 DT.91967851 DT.95130625 DT.121330539 DT.95272790

24/163 AceView cDNA sequences (see all 163 ):

BU101718 BU739879 BM713841 AB067525 BX329219 AI023777 BC048321 Z41757

BE818996 AA338578 BM142222 BF000560 BU528054 AI791755 AL713634 BX281355

CR605806 AW769465 CB852474 AA004791 BE048193 BM971599 NM_152735 AA496961

highest scoring ESTs for ZBTB9:

AA007674 AA004791 AA353032 AA496961 AA609615 AA747260 AA777448 AI023777 AI091410 AI190786

Unigene Cluster for ZBTB9:

Zinc finger and BTB domain containing 9

Hs.591805 [show with all ESTs]

Unigene Representative Sequence: NM_152735

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000395064

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB9 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB9

¹ / ² / ³

3 probe-sets matching ZBTB9 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
61365_at²^{, 3}	U95-C	2	1.00	0.50	1.00	1.00	AA007674	1.00	1.00	1.00	1
226163_at²^{, 3}	U133-B	2	1.00	0.50	--	--	AW291499	0.80	1.00	0.91	1
226163_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGAATTGAA

SOURCE GeneReport for Unigene cluster: Hs.591805

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBTB9 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ZBTB9¹	--	zinc finger and BTB domain containing 9	99.22(n) 99.58(a)	747014 XM_001171244.1 XP_001171244.1
cow (Bos taurus)	ZBTB9¹	--	zinc finger and BTB domain containing 9	86.38(n) 88.48(a)	539371 XM_586716.3 XP_586716.2
rat (Rattus norvegicus)	Zbtb9¹	--	zinc finger and BTB domain containing 9	81.29(n) 77.85(a)	294289 NM_213564.2 NP_998729.1
mouse (Mus musculus)	Zbtb9^{1, 5}	17⁵	zinc finger and BTB domain containing 9^{1, 5}	82.68(n)¹ 79.26(a)¹	474156¹ NM_001005916.2¹ NP_001005916.1¹ AI837306⁵ AK014458⁵ (see all 11)
African clawed frog (Xenopus laevis)	Xl.12662²	--	Xenopus laevis transcribed sequence with weak similarity more	75.56(n)	BJ083589.1

About this table Species with no ortholog for ZBTB9

ENSEMBL Gene Tree for ZBTB9

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB9 gene

ZBTB34² ZBTB22² ZBTB37² ZBTB43²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10 NCBI SNPs in ZBTB9 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2274730^1,2	A,C,F,H	33530523(-)	`GCCCAG/CAACAG`	1	--	ut5¹		7		EA EU WA NA	2094
	rs2772385^1,2	A,C	33530128(+)	`CTCTCG/TGTCCT`	1	--	ng5¹		0	--	--	--	--
	rs3119025^1,2	C,F,H	33530954(+)	`TCGTCG/TCTGCT`	1	S/S	syn¹		7		EU EA WA NA	676
	rs9380354^1,2	H	33531257(+)	`CAGTGC/TTCAGA`	1	C/C	syn¹		4		EU EA WA	420
	rs3827803^1,2	H	33532127(+)	`AAGCAC/TCATCT`	1	H/H	syn¹		5		EA EU WA	1914
	rs9469425^1,2	--	33531676(+)	`TCCTGC/GCCCTC`	1	A/G	mis¹		0	--	--	--	--
--	rs34517648^1,2	--	33532598(+)	`AATTA-/TTTTAG`	1	--	ut3¹		0	--	--	--	--
--	rs41267651^1,2	--	33530982(+)	`ACAGGC/GTAGAG`	1	L/V	mis¹		0	--	--	--	--
	rs34783180^1,2	--	33531131(+)	`ATTGAA/GGCCGA`	1	E/E	syn¹		1		NA	74
--	rs34930661^1,2	--	33530631(+)	`TTGTT-/GTTTGTTT`	1	--	int¹		0	--	--	--	--

About this table
The following additional 22 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs2772376	rs2247385	rs9380355	rs3119019	rs3130032	rs2274731	rs12204193
rs1755047	rs3846852	rs2772373	rs3130035	rs3119027	rs2772375	rs9394147
rs13210164	rs1755044	rs2772372	rs11964724	rs3119021	rs11759285	rs1755048
rs2772386

HapMap Linkage Disequilibrium images for ZBTB9 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for ZBTB9 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 221504	HGNC: 28323	AceView: ZBTB9	Ensembl:ENSG00000213588	euGenes: HUgn221504
ECgene: ZBTB9	H-InvDB: ZBTB9

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBTB9
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB9:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB9-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB9		Antibodies for ZBTB9
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBTB9		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ZBTB9)
	Antibodies (ZBTB9)
	Chimera RNAi (ZBTB9)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Zinc finger and BTB domain-containing protein 9)
	Antibodies (Zinc finger and BTB domain-containing protein 9)

Search OriGene for ZBTB9

Search Tocris compounds for ZBTB9

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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ZBTB9 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for ZBTB9

Summaries
for ZBTB9

Genomic Location
for ZBTB9

Proteins
for ZBTB9

Protein Domains/
Families
for ZBTB9

Gene Function
for ZBTB9

Pathways & Interactions
for ZBTB9

Drugs & Compounds
for ZBTB9

Transcripts
for ZBTB9

Expression
for ZBTB9

Orthologs
for ZBTB9

Paralogs
for ZBTB9

SNPs/Variants
for ZBTB9

Disorders & Mutations
for ZBTB9

Medical News
for ZBTB9

Publications
for ZBTB9

Search for ZBTB9

Genome Databases showing ZBTB9

Other Databases showing ZBTB9

Specialized Databases showing ZBTB9

Licensable Technologies
for ZBTB9

Services
for ZBTB9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB9 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor ZBTB9

Summariesfor ZBTB9

Genomic Locationfor ZBTB9

Proteinsfor ZBTB9

Protein Domains/Familiesfor ZBTB9

Gene Functionfor ZBTB9

Pathways & Interactionsfor ZBTB9

Drugs & Compoundsfor ZBTB9

Transcriptsfor ZBTB9

Expression for ZBTB9

Orthologsfor ZBTB9

Paralogsfor ZBTB9

SNPs/Variantsfor ZBTB9

Disorders & Mutationsfor ZBTB9

Medical Newsfor ZBTB9

Publicationsfor ZBTB9

Search for ZBTB9

Genome Databases showing ZBTB9

Other Databases showing ZBTB9

Specialized Databases showing ZBTB9

Licensable Technologiesfor ZBTB9

Servicesfor ZBTB9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB9

Summaries
for ZBTB9

Genomic Location
for ZBTB9

Proteins
for ZBTB9

Protein Domains/
Families
for ZBTB9

Gene Function
for ZBTB9

Pathways & Interactions
for ZBTB9

Drugs & Compounds
for ZBTB9

Transcripts
for ZBTB9

Expression
for ZBTB9

Orthologs
for ZBTB9

Paralogs
for ZBTB9

SNPs/Variants
for ZBTB9

Disorders & Mutations
for ZBTB9

Medical News
for ZBTB9

Publications
for ZBTB9

Licensable Technologies
for ZBTB9

Services
for ZBTB9