ZBTB9 Gene
protein-coding GIFtS: 44
GCID: GC06P033422
|
|
zinc finger and BTB domain containing 9
| |
Aliases
for ZBTB9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 91 2 | | ZNF9191 2 | | MGC231661 | | Zinc Finger And BTB Domain-Containing Protein 92 |
Export aliases for ZBTB9 gene to outside databasesPrevious GC identifers: GC06P033469 GC06P033496 GC06P033530 GC06P033164 |
Summaries
for ZBTB9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBTB9_HUMAN, Q96C00Function: May be involved in transcriptional regulation
|
Genomic Views
for ZBTB9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB9 gene promoter:
E2F-3a E2F-4 E2F-5 Sp1 p300 Olf-1 E2F-2 E2F E2F-1 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.32 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.31ZBTB9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P033422: view genomic region
(about GC identifiers)
Start:
|
33,422,356 bp from pter |
End:
|
33,425,325 bp from pter |
Size:
|
2,970 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr6+,ALT_REF_LOCI_7 33,492,065-33,495,030 |
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Proteins
for ZBTB9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBTB9_HUMAN, Q96C00 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 9 Size: 473 amino acids; 50602 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A2AB19Explore the universe of human proteins at neXtProt for ZBTB9: NX_Q96C00
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96C00
ZBTB9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689948.1
ENSEMBL proteins: ENSP00000378503
Human Recombinant Protein Products for ZBTB9:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZBTB9 for ontologies About GeneDecksing
ZBTB9 Antibody Products:
Assay Products for ZBTB9: |
Protein
Domains /
Families
for ZBTB9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB9 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96C00ProtoNet protein and cluster: Q96C00 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBTB9_HUMAN, Q96C00Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 2 C2H2-type zinc fingers |
Function
for ZBTB9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZBTB9_HUMAN, Q96C00Function: May be involved in transcriptional regulation Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZBTB9 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB9
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZBTB9 (NM_152735) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB9 |
|
Pathways & Interactions
for ZBTB9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB9
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/22 Interacting proteins for ZBTB9 (Q96C003 ENSP000003785034) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB9 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB9
Search CenterWatch for drugs/clinical trials and news about ZBTB9
|
Transcripts
for ZBTB9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB9 gene: NM_152735.3 Unigene Cluster for ZBTB9: Zinc finger and BTB domain containing 9 Hs.591805 [show with all ESTs]Unigene Representative Sequence: NM_1527352 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395064(uc003oeq.3) ENST00000487326
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB9
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB9 (NM_152735) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB9 |
Additional cDNA sequence: AK122644.1 AK313571.1 BC014978.1 BC048321.1 5 DOTS entries: DT.313158 DT.91967851 DT.95130625 DT.121330539 DT.95272790 24/163 AceView cDNA sequences (see all 163): BU101718 BM971599 AI190786 AI005224 NM_152735 BC048321 R11145 AK094225 CB852474 R50699 BM717494 BM142222 BX108836 BE048193 AW070944 BF000560 BC014978 BU528054 AA496961 AI023777 BQ920923 BF935573 AA004791 H84059
GeneLoc Exon Structure
|
Expression
for ZBTB9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAATTGAA
About this image
See ZBTB9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB9
SOURCE GeneReport for Unigene cluster: Hs.591805
SABiosciences Custom PCR Arrays for ZBTB9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB9 |
Orthologs
for ZBTB9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB9 gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ZBTB96 |
-- |
44(a) |
1 ↔ 1 |
GL343884.1(98147-99478) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.126622 |
Xenopus laevis transcribed sequence with weak similarity more |
75.56(n) |
|
BJ083589.1 |
ENSEMBL Gene Tree for ZBTB9 (if available)
TreeFam Gene Tree for ZBTB9 (if available) |
Paralogs
for ZBTB9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB9 gene
- ZBTB222 ZBTB342 NACC12 ZBTB62 ZBTB452 NACC22 ZBTB432 ZBTB262
- ZBTB122 ZBTB372 ZBTB202
1 SIMAP similar gene for ZBTB9 using alignment to 1 protein entry: ZBTB9_HUMAN:ZBTB43
ZBTB9 for paralogs About GeneDecksing
|
Genomic Variants
for ZBTB9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB9 (33422356 - 33425325 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBTB9: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB9 |
|
Disorders
/ Diseases
for ZBTB9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBTB9 for disorders About GeneDecksing
3  diseases for ZBTB9: About MalaCardssystemic lupus erythematosus lupus erythematosus copd
Human Genome Epidemiology (HuGE) Navigator: ZBTB9 (2 documents)
Export disorders for ZBTB9 gene to outside databases
|
Publications
for ZBTB9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB9 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ZBTB9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genome-wide association study of smoking behaviours i n patients with COPD. (PubMed id 21685187)1 Siedlinski M....Silverman E.K. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
|
External Searches for ZBTB9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB9 gene:
Search GeneIP for patents involving ZBTB9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZBTB9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBTB9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB9 | | | OriGene Protein Over-expression Lysate for ZBTB9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZBTB9 | | OriGene 3'-UTR Clone for ZBTB9 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBTB9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB9 |
| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB9 |
|  |  |  |  | | | | ThermoFisher Antibodies for ZBTB9 |
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