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Aliases for ZBTB8OS Gene

Aliases for ZBTB8OS Gene

  • Zinc Finger And BTB Domain Containing 8 Opposite Strand 2 3 5
  • Zinc Finger And BTB Domain-Containing Opposite Strand Protein 8 3 4
  • ARCH 3 4
  • Archease-Like Protein 3
  • Protein Archease 3
  • Archease (ARCH) 3
  • Protein ZBTB8OS 4
  • Archease 2
  • ARCH2 3

External Ids for ZBTB8OS Gene

Previous GeneCards Identifiers for ZBTB8OS Gene

  • GC01M032735
  • GC01M032838
  • GC01M033065
  • GC01M031202

Summaries for ZBTB8OS Gene

GeneCards Summary for ZBTB8OS Gene

ZBTB8OS (Zinc Finger And BTB Domain Containing 8 Opposite Strand) is a Protein Coding gene. Diseases associated with ZBTB8OS include Benign Perivascular Tumor and Cardiovascular Organ Benign Neoplasm. Among its related pathways are Gene Expression and tRNA processing.

UniProtKB/Swiss-Prot for ZBTB8OS Gene

  • Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.

Additional gene information for ZBTB8OS Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB8OS Gene

Genomics for ZBTB8OS Gene

Regulatory Elements for ZBTB8OS Gene

Enhancers for ZBTB8OS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H032262 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18 +385.6 385626 4 ZNF493 ZFP64 RARA SCRT2 ZNF654 ZNF680 ZC3H11A CEBPB OVOL3 REST TXLNA RBBP4 KHDRBS1 SNRNP40 TMEM39B ZBTB8A ZNF362 DCDC2B TSSK3 S100PBP
GH01H032271 1.5 Ensembl ENCODE dbSUPER 18.2 +377.5 377464 5 ZNF493 ZNF133 GLI4 ETS1 ZNF121 GLIS2 SP3 YY2 NCOA1 SMARCA4 RBBP4 ZBTB8A TXLNA KHDRBS1 IQCC SNRNP40 S100PBP ZBTB8B ENSG00000224066 ZNF362
GH01H033361 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 9.7 -713.7 -713689 7 PKNOX1 ATF1 ZNF493 ZFP64 ZNF133 ARID4B FEZF1 ZNF2 TCF12 ZNF766 ZBTB8A RBBP4 ZSCAN20 S100PBP BSDC1 PHC2 CSMD2-AS1 ZBTB8B ZNF362 CSMD2
GH01H031924 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +715.2 715181 22 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B PUM1 EIF3I
GH01H033336 2 FANTOM5 Ensembl ENCODE dbSUPER 10 -692.7 -692724 15 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 PHC2 S100PBP A3GALT2 RBBP4 BSDC1 ENSG00000225313 TRIM62 ZSCAN20 ENSG00000270115 ZBTB8OS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB8OS on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB8OS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004386 213 2801 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D GLIS1

Genomic Location for ZBTB8OS Gene

Chromosome:
1
Start:
32,600,172 bp from pter
End:
32,651,013 bp from pter
Size:
50,842 bases
Orientation:
Minus strand

Genomic View for ZBTB8OS Gene

Genes around ZBTB8OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB8OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB8OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB8OS Gene

Proteins for ZBTB8OS Gene

  • Protein details for ZBTB8OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWT0-ARCH_HUMAN
    Recommended name:
    Protein archease
    Protein Accession:
    Q8IWT0
    Secondary Accessions:
    • Q5TGK5
    • Q6PDA1
    • Q8IWS9
    • Q8NEV6
    • Q8NEV7

    Protein attributes for ZBTB8OS Gene

    Size:
    167 amino acids
    Molecular mass:
    19491 Da
    Quaternary structure:
    • Component of the tRNA-splicing ligase complex.
    SequenceCaution:
    • Sequence=AAM34477.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN75223.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN75224.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20020.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20021.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBTB8OS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB8OS Gene

Post-translational modifications for ZBTB8OS Gene

  • Ubiquitination at isoforms=112
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZBTB8OS Gene

Domains & Families for ZBTB8OS Gene

Gene Families for ZBTB8OS Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZBTB8OS Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWT0

UniProtKB/Swiss-Prot:

ARCH_HUMAN :
  • Belongs to the archease family.
Family:
  • Belongs to the archease family.
genes like me logo Genes that share domains with ZBTB8OS: view

Function for ZBTB8OS Gene

Molecular function for ZBTB8OS Gene

UniProtKB/Swiss-Prot Function:
Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.

Gene Ontology (GO) - Molecular Function for ZBTB8OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB8OS: view
genes like me logo Genes that share phenotypes with ZBTB8OS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB8OS Gene

Localization for ZBTB8OS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB8OS gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB8OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0070062 extracellular exosome IDA 23376485
GO:0072669 tRNA-splicing ligase complex IDA 24870230
genes like me logo Genes that share ontologies with ZBTB8OS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZBTB8OS Gene

Pathways & Interactions for ZBTB8OS Gene

genes like me logo Genes that share pathways with ZBTB8OS: view

Pathways by source for ZBTB8OS Gene

3 Reactome pathways for ZBTB8OS Gene

Gene Ontology (GO) - Biological Process for ZBTB8OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS --
GO:0008033 tRNA processing IEA --
genes like me logo Genes that share ontologies with ZBTB8OS: view

No data available for SIGNOR curated interactions for ZBTB8OS Gene

Drugs & Compounds for ZBTB8OS Gene

No Compound Related Data Available

Transcripts for ZBTB8OS Gene

Unigene Clusters for ZBTB8OS Gene

Zinc finger and BTB domain containing 8 opposite strand:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8OS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: -
SP3: - - -
SP4: - -
SP5: - - - - - - - -
SP6:

Relevant External Links for ZBTB8OS Gene

GeneLoc Exon Structure for
ZBTB8OS
ECgene alternative splicing isoforms for
ZBTB8OS

Expression for ZBTB8OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB8OS Gene

Protein differential expression in normal tissues from HIPED for ZBTB8OS Gene

This gene is overexpressed in Tlymphocyte (8.2), Monocytes (8.0), and Oral epithelium (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB8OS Gene



Protein tissue co-expression partners for ZBTB8OS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB8OS Gene:

ZBTB8OS

SOURCE GeneReport for Unigene cluster for ZBTB8OS Gene:

Hs.655921
genes like me logo Genes that share expression patterns with ZBTB8OS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB8OS Gene

Orthologs for ZBTB8OS Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB8OS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB8OS 33
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia ZBTB8OS 33 34
  • 94.6 (n)
cow
(Bos Taurus)
Mammalia ZBTB8OS 33 34
  • 92.33 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zbtb8os 33 16 34
  • 89.62 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb8os 33
  • 89.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB8OS 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB8OS 33 34
  • 78.83 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB8OS 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb8os 33
  • 74.33 (n)
Str.17752 33
zebrafish
(Danio rerio)
Actinopterygii zbtb8os 33 34
  • 71.28 (n)
Dr.10898 33
fruit fly
(Drosophila melanogaster)
Insecta CG6353 33 34
  • 59.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001976 33
  • 58.7 (n)
worm
(Caenorhabditis elegans)
Secernentea C43H8.1 33 34
  • 55.88 (n)
Species where no ortholog for ZBTB8OS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZBTB8OS Gene

ENSEMBL:
Gene Tree for ZBTB8OS (if available)
TreeFam:
Gene Tree for ZBTB8OS (if available)

Paralogs for ZBTB8OS Gene

(1) SIMAP similar genes for ZBTB8OS Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZBTB8OS Gene

genes like me logo Genes that share paralogs with ZBTB8OS: view

No data available for Paralogs for ZBTB8OS Gene

Variants for ZBTB8OS Gene

Sequence variations from dbSNP and Humsavar for ZBTB8OS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000032996 -- 32,632,413(+) TGCAG(G/T)TTTTT intron-variant, downstream-variant-500B
rs1000069292 -- 32,625,924(+) GGAGT(A/G)TGCAA intron-variant
rs1000078789 -- 32,637,539(+) CTCCA(C/G)TGTGG intron-variant, upstream-variant-2KB
rs1000235263 -- 32,632,198(+) GAGAC(A/G)GGGTT intron-variant, downstream-variant-500B
rs1000339242 -- 32,625,733(+) ATAAA(C/T)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB8OS Gene

Variant ID Type Subtype PubMed ID
esv2667534 CNV deletion 23128226
esv2746519 CNV deletion 23290073
esv3585673 CNV loss 21293372
esv3585674 CNV loss 21293372
esv3893501 CNV loss 25118596
nsv1005213 CNV gain 25217958
nsv1113098 CNV deletion 24896259
nsv461039 CNV loss 19166990
nsv512733 CNV insertion 21212237
nsv519188 CNV loss 19592680
nsv545961 CNV loss 21841781

Variation tolerance for ZBTB8OS Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB8OS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB8OS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB8OS Gene

Disorders for ZBTB8OS Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZBTB8OS Gene - From: DISEASES

Disorder Aliases PubMed IDs
benign perivascular tumor
  • benign pericytic neoplasm
cardiovascular organ benign neoplasm
glomangioma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZBTB8OS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB8OS
genes like me logo Genes that share disorders with ZBTB8OS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB8OS Gene

Publications for ZBTB8OS Gene

  1. Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. (PMID: 24870230) Popow J … Martinez J (Nature 2014) 2 3 4 60
  2. Age-related mutations and chronic myelomonocytic leukemia. (PMID: 26648538) Mason CC … Deininger MW (Leukemia 2016) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  5. The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. (PMID: 25378478) Jurkin J … Martinez J (The EMBO journal 2014) 3 60

Products for ZBTB8OS Gene

Sources for ZBTB8OS Gene

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