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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB8OS Gene

protein-coding   GIFtS: 43
GCID: GC01M033065

Zinc Finger And BTB Domain Containing 8 Opposite Strand

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 8 Opposite Strand1 2     Archease (ARCH)2
Zinc Finger And BTB Domain-Containing Opposite Strand Protein 82 3     Archease-Like Protein2
ARCH2 3     Protein Archease2
archease1     Protein ZBTB8OS3
ARCH22     

External Ids:    HGNC: 240941   Entrez Gene: 3394872   Ensembl: ENSG000001762617   UniProtKB: Q8IWT03   

Export aliases for ZBTB8OS gene to outside databases

Previous GC identifers: GC01M032735 GC01M032838 GC01M031202


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZBTB8OS Gene: 
ZBTB8OS (zinc finger and BTB domain containing 8 opposite strand) is a protein-coding gene. Diseases associated with ZBTB8OS include glomangioma, and spondylolysis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB8OS gene promoter:
         COUP-TF1   NF-1   p53   COUP   HNF-4alpha2   STAT5A   HNF-4alpha1   Gfi-1   COUP-TF   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB8OS promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB8OS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB8OS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

ZBTB8OS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB8OS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M033065:  view genomic region     (about GC identifiers)

Start:
33,065,773 bp from pter      End:
33,116,504 bp from pter
Size:
50,732 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARCH_HUMAN, Q8IWT0 (See protein sequence)
Recommended Name: Protein archease  
Size: 167 amino acids; 19491 Da
Sequence caution: Sequence=AAM34477.1; Type=Erroneous initiation; Sequence=AAN75223.1; Type=Erroneous initiation;
Sequence=AAN75224.1; Type=Erroneous initiation; Sequence=CAI20020.1; Type=Erroneous initiation;
Sequence=CAI20021.1; Type=Erroneous initiation;
Secondary accessions: Q5TGK5 Q6PDA1 Q8IWS9 Q8NEV6 Q8NEV7
Alternative splicing: 2 isoforms:  Q8IWT0-1   Q8IWT0-2   

Explore the universe of human proteins at neXtProt for ZBTB8OS: NX_Q8IWT0

Explore proteomics data for ZBTB8OS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IWT0

  • ZBTB8OS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBTB8OS Protein Expression
    REFSEQ proteins: NP_848642.1  
    ENSEMBL proteins: 
     ENSP00000417677   ENSP00000474993   ENSP00000413485   ENSP00000343760   ENSP00000362600  

    Human Recombinant Protein Products for ZBTB8OS: 
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    Browse Sino Biological Cell Lysates 
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    Browse Proteins at Cloud-Clone Corp. 


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR023572 Archease_dom
     IPR002804 Archease

    Graphical View of Domain Structure for InterPro Entry Q8IWT0

    ProtoNet protein and cluster: Q8IWT0

    1 Blocks protein domain: IPB002804 Protein of unknown function DUF101

    UniProtKB/Swiss-Prot: ARCH_HUMAN, Q8IWT0
    Similarity: Belongs to the archease family


    ZBTB8OS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB8OS:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBTB8OS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZBTB8OS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBTB8OS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZBTB8OS 

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZBTB8OS:
    hsa-miR-26b*
    SwitchGear 3'UTR luciferase reporter plasmidZBTB8OS 3' UTR sequence
    Inhib. RNA
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    Search LifeMap BioReagents cell lines for ZBTB8OS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB8OS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB8OS

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/7 Interacting proteins for ZBTB8OS (Q8IWT03 ENSP000004176774) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCHP247233, ENSP000003291274I2D: score=3 STRING: ENSP00000329127
    DNAJB4Q9UDY43I2D: score=5 
    EEF1GP266413I2D: score=5 
    RPL35AP180773I2D: score=5 
    SNRPNP631623I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB8OS (ARCH)

    Search CenterWatch for drugs/clinical trials and news about ZBTB8OS / ARCH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZBTB8OS gene: 
    NM_178547.2  

    Unigene Cluster for ZBTB8OS:

    Zinc finger and BTB domain containing 8 opposite strand
    Hs.655921  [show with all ESTs]
    Unigene Representative Sequence: BM926729
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468695(uc001bvp.3 uc001bvq.3) ENST00000492007 ENST00000373506
    ENST00000467652 ENST00000498691 ENST00000478041 ENST00000473294 ENST00000436661
    ENST00000476493 ENST00000465588 ENST00000483138 ENST00000479075 ENST00000473383
    ENST00000466361 ENST00000341885(uc001bvo.1) ENST00000373501
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZBTB8OS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZBTB8OS:
    hsa-miR-26b*
    SwitchGear 3'UTR luciferase reporter plasmidZBTB8OS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZBTB8OS
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    Sirion Biotech Customized lentivirus for stable overexpression of ZBTB8OS 
                         Customized lentivirus expression plasmids for stable overexpression of ZBTB8OS 
    Primer
    Products:
        
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB8OS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB8OS

    Additional mRNA sequence: 

    AK289480.1 AY099493.1 AY099494.1 AY151084.1 AY151085.1 AY158005.1 BC058843.1 

    22 DOTS entries:

    DT.452027  DT.86847215  DT.86847214  DT.121463505  DT.452557  DT.121463613  DT.100694730  DT.113093 
    DT.95273809  DT.100822473  DT.102938  DT.121463388  DT.121463393  DT.121463461  DT.121463473  DT.121463517 
    DT.91683555  DT.91864904  DT.92426544  DT.95340194  DT.121016180  DT.121463392 

    24/108 AceView cDNA sequences (see all 108):

    AY151085 CK300390 AI130814 AI685002 NM_178547 AA453820 AI146994 AY099493 
    AI141208 AI168644 AA524479 AY158005 AI254355 AI148643 BQ184501 AI203647 
    CK819208 AA927666 AY151084 AA582236 AA316493 AA757210 BF725478 BI859460 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8OS (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:              -                       -           -               
    SP2:                                      -                           
    SP3:                                      -     -     -               
    SP4:              -     -                                             
    SP5:              -     -     -     -     -     -     -     -         


    ECgene alternative splicing isoforms for ZBTB8OS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB8OS expression in normal human tissues (normalized intensities)      ZBTB8OS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGATACTG
    ZBTB8OS Expression
    About this image


    ZBTB8OS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Endothelium (Cardiovascular System)
             blood vessel   

    See ZBTB8OS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB8OS

    SOURCE GeneReport for Unigene cluster: Hs.655921
        SABiosciences Custom PCR Arrays for ZBTB8OS
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB8OS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZBTB8OS gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb8os1 , 5 zinc finger and BTB domain containing 8 opposite strand1, 5 89.62(n)1
    95.81(a)1
      4 (63.26 cM)5
    671061  NM_025970.31  NP_080246.11 
     1293356955 
    chicken
    (Gallus gallus)
    Aves ZBTB8OS1 zinc finger and BTB domain containing 8 opposite strand 78.83(n)
    86.16(a)
      419663  XM_417810.2  XP_417810.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB8OS6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL343706.1(267330-272566)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.177522 Transcribed sequence with weak similarity to protein more 75.86(n)    141998339 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.108982 Transcribed sequence with weak similarity to protein more 75.3(n)    57061751 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63531 CG6353 59.66(n)
    60.14(a)
      42551  NM_142718.1  NP_650975.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C43H8.11 Protein C43H8.1 55.4(n)
    46.76(a)
      183428  NM_060377.3  NP_492778.1 


    ENSEMBL Gene Tree for ZBTB8OS (if available)
    TreeFam Gene Tree for ZBTB8OS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB8OS gene
    1 SIMAP similar gene for ZBTB8OS using alignment to 4 protein entries:     ARCH_HUMAN (see all proteins):
    ARCH

    ZBTB8OS for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZBTB8OS
    PGOHUM00000240548 PGOHUM00000250797


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/621 SNPs in ZBTB8OS are shown (see all 621)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37379971,2
    C,F--33086809(-) TTAGCT/CAGGAT 1 -- ds50015Minor allele frequency- C:0.30NA WA CSA 10
    rs1404885081,2
    --33086819(+) ACACAA/GTGAAA 1 -- ds50010--------
    rs1807588201,2
    C--33086861(+) CGGGCA/G/TTGGTG 1 -- ds50010--------
    rs3599581,2
    C,A--33086905(-) ctcctA/Gcctca 1 -- ds5001 ese30--------
    rs1842206631,2
    --33086925(+) AACCCA/GGGAGG 1 -- ds50010--------
    rs66740041,2
    C,A--33086944(+) gcagtA/Gagccg 1 -- ds5001 ese30--------
    rs1907637911,2
    --33087028(+) AAAATA/GTATGT 1 -- ds50010--------
    rs66741111,2
    C,F,A,H--33087052(+) GAAGAA/GAAACA 1 -- ds5001 trp310Minor allele frequency- G:0.05NS EA NA CSA WA 1315
    rs1818907091,2
    --33087120(+) GCCTCA/GGGCTG 1 -- ds50010--------
    rs1862848151,2
    --33087121(+) CCTCAA/GGCTGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZBTB8OS (33065773 - 33116504 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZBTB8OS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746519CNV Deletion23290073
    esv2667534CNV Deletion23128226
    nsv461039CNV Loss19166990
    nsv519188CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for ZBTB8OS:    About MalaCards
    glomangioma    spondylolysis    goldenhar syndrome


    ZBTB8OS for disorders           About GeneDecksing


    Export disorders for ZBTB8OS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB8OS gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZBTB8OS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    3. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. Predicted role for the archease protein family based on structural and sequence analysis of TM1083 and MTH1598, two proteins structurally characterized through structural genomics efforts. (PubMed id 15162483)2 Canaves J.M. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339487 HGNC: 24094 AceView: ARCH Ensembl:ENSG00000176261 euGenes: HUgn339487
    ECgene: ZBTB8OS H-InvDB: ZBTB8OS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB8OS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZBTB8OS gene:
    Search GeneIP for patents involving ZBTB8OS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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