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Aliases for ZBTB8OS Gene

Aliases for ZBTB8OS Gene

  • Zinc Finger And BTB Domain Containing 8 Opposite Strand 2 3 5
  • Zinc Finger And BTB Domain-Containing Opposite Strand Protein 8 3 4
  • ARCH 3 4
  • Archease-Like Protein 3
  • Protein Archease 3
  • Archease (ARCH) 3
  • Protein ZBTB8OS 4
  • Archease 2
  • ARCH2 3

External Ids for ZBTB8OS Gene

Previous GeneCards Identifiers for ZBTB8OS Gene

  • GC01M032735
  • GC01M032838
  • GC01M033065
  • GC01M031202

Summaries for ZBTB8OS Gene

GeneCards Summary for ZBTB8OS Gene

ZBTB8OS (Zinc Finger And BTB Domain Containing 8 Opposite Strand) is a Protein Coding gene. Diseases associated with ZBTB8OS include Benign Perivascular Tumor and Cardiovascular Organ Benign Neoplasm. Among its related pathways are tRNA processing and Gene Expression.

UniProtKB/Swiss-Prot for ZBTB8OS Gene

  • Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB8OS Gene

Genomics for ZBTB8OS Gene

Regulatory Elements for ZBTB8OS Gene

Enhancers for ZBTB8OS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F032771 1 ENCODE 10.7 -123.1 -123105 5.1 HDGF SIN3A ARID4B ZNF48 ZNF2 ZNF766 GLIS2 ZNF143 ZNF548 PAF1 KPNA6 FNDC5 EIF3I KIAA1522 ENSG00000224409 SYNC YARS S100PBP RBBP4 ZBTB8OS
GH01F032496 1 Ensembl ENCODE 10.6 +154.7 154713 0.6 HDGF ETV1 CEBPG YY1 IRF9 PRDM10 ZNF362 RNF2 HLF CEBPB ENSG00000254553 ZBTB8B ZBTB8A ENSG00000224409 RBBP4 ZBTB8OS LOC105378629 FNDC5 GC01P032498
GH01F032626 0.7 ENCODE 12.5 +23.1 23120 2.2 CTCF BCOR PKNOX1 MTA2 BHLHE40 ZMYM3 TBX21 IKZF1 NBN ZBTB33 SYNC RBBP4 ZBTB8OS ZBTB8A EIF3I TMEM234 ENSG00000224066 DCDC2B GC01M032619 LOC102723870
GH01F032494 0.8 ENCODE 10.6 +156.6 156637 1.7 SOX13 PKNOX1 ATF1 TAL1 CEBPG ZFHX2 NCOR1 TRIM24 PRDM10 ZNF600 ENSG00000254553 ZBTB8B ZBTB8A RBBP4 ZBTB8OS LOC105378629 FNDC5 TSSK3 GC01P032498
GH01F032796 0.8 ENCODE 10.4 -148.1 -148126 5.5 HDGF PKNOX1 ZMYM3 KLF17 ZNF664 GLIS2 SCRT2 FOS MAFK ZNF652 FNDC5 KIAA1522 SYNC RBBP4 ZBTB8OS S100PBP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB8OS on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB8OS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001518967 113 3401 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for ZBTB8OS Gene

Chromosome:
1
Start:
32,600,172 bp from pter
End:
32,651,013 bp from pter
Size:
50,842 bases
Orientation:
Minus strand

Genomic View for ZBTB8OS Gene

Genes around ZBTB8OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB8OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB8OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB8OS Gene

Proteins for ZBTB8OS Gene

  • Protein details for ZBTB8OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWT0-ARCH_HUMAN
    Recommended name:
    Protein archease
    Protein Accession:
    Q8IWT0
    Secondary Accessions:
    • Q5TGK5
    • Q6PDA1
    • Q8IWS9
    • Q8NEV6
    • Q8NEV7

    Protein attributes for ZBTB8OS Gene

    Size:
    167 amino acids
    Molecular mass:
    19491 Da
    Quaternary structure:
    • Component of the tRNA-splicing ligase complex.
    SequenceCaution:
    • Sequence=AAM34477.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN75223.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN75224.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20020.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20021.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBTB8OS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB8OS Gene

Post-translational modifications for ZBTB8OS Gene

  • Ubiquitination at Lys 112
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZBTB8OS Gene

Domains & Families for ZBTB8OS Gene

Protein Domains for ZBTB8OS Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWT0

UniProtKB/Swiss-Prot:

ARCH_HUMAN :
  • Belongs to the archease family.
Family:
  • Belongs to the archease family.
genes like me logo Genes that share domains with ZBTB8OS: view

No data available for Gene Families for ZBTB8OS Gene

Function for ZBTB8OS Gene

Molecular function for ZBTB8OS Gene

UniProtKB/Swiss-Prot Function:
Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.

Gene Ontology (GO) - Molecular Function for ZBTB8OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB8OS: view
genes like me logo Genes that share phenotypes with ZBTB8OS: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB8OS Gene

Localization for ZBTB8OS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB8OS gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB8OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0070062 extracellular exosome IDA 23376485
GO:0072669 tRNA-splicing ligase complex IDA 24870230
genes like me logo Genes that share ontologies with ZBTB8OS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZBTB8OS Gene

Pathways & Interactions for ZBTB8OS Gene

genes like me logo Genes that share pathways with ZBTB8OS: view

Pathways by source for ZBTB8OS Gene

3 Reactome pathways for ZBTB8OS Gene

Interacting Proteins for ZBTB8OS Gene

Gene Ontology (GO) - Biological Process for ZBTB8OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS --
GO:0008033 tRNA processing IEA --
genes like me logo Genes that share ontologies with ZBTB8OS: view

No data available for SIGNOR curated interactions for ZBTB8OS Gene

Transcripts for ZBTB8OS Gene

Unigene Clusters for ZBTB8OS Gene

Zinc finger and BTB domain containing 8 opposite strand:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8OS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: -
SP3: - - -
SP4: - -
SP5: - - - - - - - -
SP6:

Relevant External Links for ZBTB8OS Gene

GeneLoc Exon Structure for
ZBTB8OS
ECgene alternative splicing isoforms for
ZBTB8OS

Expression for ZBTB8OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB8OS Gene

Protein differential expression in normal tissues from HIPED for ZBTB8OS Gene

This gene is overexpressed in Tlymphocyte (8.2), Monocytes (8.0), and Oral epithelium (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB8OS Gene



Protein tissue co-expression partners for ZBTB8OS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB8OS Gene:

ZBTB8OS

SOURCE GeneReport for Unigene cluster for ZBTB8OS Gene:

Hs.655921
genes like me logo Genes that share expression patterns with ZBTB8OS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB8OS Gene

Orthologs for ZBTB8OS Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB8OS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB8OS 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia ZBTB8OS 34 35
  • 94.6 (n)
cow
(Bos Taurus)
Mammalia ZBTB8OS 34 35
  • 92.33 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zbtb8os 34 16 35
  • 89.62 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb8os 34
  • 89.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB8OS 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB8OS 34 35
  • 78.83 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB8OS 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb8os 34
  • 74.33 (n)
Str.17752 34
zebrafish
(Danio rerio)
Actinopterygii zbtb8os 34 35
  • 71.28 (n)
Dr.10898 34
fruit fly
(Drosophila melanogaster)
Insecta CG6353 34 35
  • 59.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001976 34
  • 58.7 (n)
worm
(Caenorhabditis elegans)
Secernentea C43H8.1 34 35
  • 55.88 (n)
Species where no ortholog for ZBTB8OS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZBTB8OS Gene

ENSEMBL:
Gene Tree for ZBTB8OS (if available)
TreeFam:
Gene Tree for ZBTB8OS (if available)

Paralogs for ZBTB8OS Gene

(1) SIMAP similar genes for ZBTB8OS Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZBTB8OS Gene

genes like me logo Genes that share paralogs with ZBTB8OS: view

No data available for Paralogs for ZBTB8OS Gene

Variants for ZBTB8OS Gene

Sequence variations from dbSNP and Humsavar for ZBTB8OS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157362 -- 32,639,851(+) caata(C/T)agtca intron-variant
rs10449233 -- 32,632,848(+) AAACA(C/G)ATATA intron-variant, utr-variant-3-prime
rs1048216 -- 32,650,519(-) GCAGG(A/T)AGAGG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1088136 -- 32,646,851(+) ggcca(A/G)catgg intron-variant
rs10914587 -- 32,621,571(+) CTTGC(A/C)TTGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZBTB8OS Gene

Variant ID Type Subtype PubMed ID
esv2667534 CNV deletion 23128226
esv2746519 CNV deletion 23290073
esv3585673 CNV loss 21293372
esv3585674 CNV loss 21293372
esv3893501 CNV loss 25118596
nsv1005213 CNV gain 25217958
nsv1113098 CNV deletion 24896259
nsv461039 CNV loss 19166990
nsv512733 CNV insertion 21212237
nsv519188 CNV loss 19592680
nsv545961 CNV loss 21841781

Variation tolerance for ZBTB8OS Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB8OS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB8OS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB8OS Gene

Disorders for ZBTB8OS Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZBTB8OS Gene - From: DISEASES

Disorder Aliases PubMed IDs
benign perivascular tumor
  • benign pericytic neoplasm
cardiovascular organ benign neoplasm
glomangioma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZBTB8OS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB8OS
genes like me logo Genes that share disorders with ZBTB8OS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB8OS Gene

Publications for ZBTB8OS Gene

  1. Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. (PMID: 24870230) Popow J. … Martinez J. (Nature 2014) 2 3 4 64
  2. Age-related mutations and chronic myelomonocytic leukemia. (PMID: 26648538) Mason C.C. … Deininger M.W. (Leukemia 2016) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. (PMID: 25378478) Jurkin J. … Martinez J. (EMBO J. 2014) 3 64

Products for ZBTB8OS Gene

Sources for ZBTB8OS Gene

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