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ZBTB8OS Gene

protein-coding   GIFtS: 44

GC01M032838
zinc finger and BTB domain containing 8 opposite strand
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
ARCH 1, 2, 3
ARCH2 2
MGC62007 2
OTTHUMP00000009581 2
Descriptions
Protein ZBTB8OS 3
Zinc finger and BTB domain-containing opposite strand
protein 8 3
archease (ARCH) 2
archease-like protein 2
zinc finger and BTB domain containing 8 opposite strand 2
External Ids
HGNC: 240941
Entrez Gene: 3394872
UniProtKB: Q8IWT03
Ensembl: ENSG000001762617
Search outside databases for aliases for ZBTB8OS gene

Previous GC identifer: GC01M032735

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB8OS gene  

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

ZBTB8OS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M032838:     (about GC identifiers)

Start:
32,838,441 bp from pter
End:
32,889,120 bp from pter
Size:
50,680 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ARCH_HUMAN, Q8IWT0 (See protein sequence)
Recommended Name: Protein archease  
Size: 167 amino acids; 19491 Da
Secondary accessions: Q5TGK5 Q6PDA1 Q8IWS9 Q8NEV6 Q8NEV7
Alternative splicing: 2 isoforms:  Q8IWT0-1   Q8IWT0-2   

REFSEQ proteins: NP_848642.1  

ENSEMBL proteins: 
ENSP00000362600 ENSP00000362605 ENSP00000343760 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (ZBTB8OS)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for ZBTB8OS: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for ZBTB8OS

Assays for ZBTB8OS: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR002804 Archease_tRNA_MeTfrase_chp


   GeneDecks  ZBTB8OS for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8IWT0

ProtoNet protein and cluster: Q8IWT0

1 Blocks protein family: IPB002804 Protein of unknown function DUF101

UniProtKB/Swiss-Prot: ARCH_HUMAN, Q8IWT0
Similarity: Belongs to the UPF0211 (archease) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBTB8OS)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178547

              Applied Biosystems Silencer® siRNAs for ZBTB8OS

              Sigma-Aldrich siRNA for ZBTB8OS  
                     Sigma-Aldrich shRNA for ZBTB8OS  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for ZBTB8OS
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178547
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178547
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_178547 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_178547

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for ZBTB8OS (ENSP000003626053) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
C22orf28ENSP000002160383STRING (score=.885)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB8OS

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBTB8OS)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178547

              Sigma-Aldrich siRNA for ZBTB8OS  
                     Sigma-Aldrich shRNA for ZBTB8OS  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_178547  

REFSEQ mRNAs for ZBTB8OS gene: 

NM_178547.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_178547  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178547
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178547
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_178547 

Additional cDNA sequence: 

AK289480.1 AY099493.1 AY099494.1 AY151084.1 AY151085.1 AY158005.1 BC058843.1 

23 DOTS entries:

DT.452027  DT.86847215  DT.86847214  DT.121463505  DT.452557  DT.121463613  DT.100694730  DT.113093 
DT.95273809  DT.100822473  DT.102938  DT.121463388  DT.121463393  DT.121463461  DT.121463473  DT.121463517 
DT.91683555  DT.91864904  DT.92426544  DT.95340194  DT.100016812  DT.121016180  DT.121463392 

24/108 AceView cDNA sequences (see all 108 ):

AA582236 AY151084 AI168644 AA453820 AY158005 AI685002 CK819208 AI254355 
NM_178547 AY151085 AA927666 AY099493 AI130814 AI141208 AA316493 CK300390 
AI203647 AA524479 BQ184501 AI146994 AI148643 AI377292 BQ187597 BM142307 

highest scoring ESTs for ZBTB8OS:

W44356 AI141208 AI190610 AI377292 AL598963 AY099493 AY099494 AY151084 AY151085 BM128183 

Unigene Cluster for ZBTB8OS:

Zinc finger and BTB domain containing 8 opposite strand
Hs.655921  [show with all ESTs]
Unigene Representative Sequence: BM926729


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8OS (see all 6 )

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1:              -                       -           -               
SP2:                                      -                           
SP3:                                      -     -     -               
SP4:              -     -                                             
SP5:              -     -     -     -     -     -     -     -         

About this scheme

ECgene alternative splicing isoforms for ZBTB8OS

3 Ensembl transcripts including schematic representations:
ENST00000373501  ENST00000373506  ENST00000341885  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ZBTB8OS expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB8OS

1 / 2 / 3

4 probe-sets matching ZBTB8OS gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

53124_r_at2, 3 U95-B 2 1.00 0.94 0.67 0.66 W44356 1.00 1.00 1.00 1
53123_s_at2, 3 U95-B 4 1.00 0.58 0.77 1.35 W44356 1.00 1.00 1.00 1

228970_at2, 3 U133-B 4 1.00 0.61 -- -- BG249305 0.60 1.00 0.82 1

228970_at2 U133Plus2 4 1.00 0.61 -- -- -- -- -- -- --
GeneDecks  ZBTB8OS for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ACAGATACTG

SOURCE GeneReport for Unigene cluster: Hs.655921
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ZBTB8OS gene from 5/11 species (see all 11 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ZBTB8OS1   -- zinc finger and BTB domain containing 8 opposite strand 94.6(n)
94.97(a)
478150  XM_535326.2  XP_535326.2 
chimpanzee
(Pan troglodytes)
ZBTB8OS1   -- zinc finger and BTB domain containing 8 opposite strand 99.63(n)
99.44(a)
456718  XM_001163575.1  XP_001163575.1 
cow
(Bos taurus)
ZBTB8OS1   -- zinc finger and BTB domain containing 8 opposite strand 92.33(n)
95.68(a)
613795  NM_001076288.1  NP_001069756.1 
mouse
(Mus musculus)
Zbtb8os1, 5 45
zinc finger and BTB domain containing 8 opposite strand1, 5 89.62(n)1
95.81(a)1
671061  NM_025970.21  NP_080246.11 
 AI8508445  AI8512265  (see all 17)
chicken
(Gallus gallus)
ZBTB8OS1   -- zinc finger and BTB domain containing 8 opposite strand 78.83(n)
86.16(a)
419663  XM_001233489.1  XP_001233490.1 
About this table        Species with no ortholog for ZBTB8OS

ENSEMBL Gene Tree for ZBTB8OS
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ZBTB8OS gene
ENSG000001834322  LOC7298982  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/181 NCBI SNPs in ZBTB8OS are shown (see all 181 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 59)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs37536031,2
A,C,F,H32860024(-) TCCTAC/TGAAGA 1 -- ut31 ese34Minor allele frequency- T:0.18EU EA WA 418
rs66741111,2
A,C,F,H32859639(+) GAAGAA/GAAACA 1 -- ng51 trp34Minor allele frequency- G:0.02EU EA WA 418
--
rs66740041,2
A32859531(+) gcagtA/Gagccg 1 -- ng51 ese30--------
--
rs37379971,2
C32859396(-) ttagcC/Taggat 1 -- ng510--------
--
rs3599581,2
A32859492(-) ctcctA/Gcctca 1 -- ng51 ese30--------
rs7048781,2
A,C,F,O32872224(-) GCATTT/CGAGCA 1 F/F syn13Minor allele frequency- C:0.13NA EA 252
rs7048761,2
A,C,F,H,O32861028(-) GGTTTG/TGATTT 1 -- int112Minor allele frequency- N:0.00EU EA WA NA 1052
rs7048771,2
A,C,F,H,O32872385(-) AGTGCC/TGTTAA 1 -- int18Minor allele frequency- N:0.01EU EA WA NA 632
rs75181661,2
A,C,F,H32861957(+) tagaaA/Cgttct 1 -- int14Minor allele frequency- C:0.03EU EA WA 420
rs75554931,2
A,C,F,H32878830(+) tcccaG/Agtggt 1 -- int14Minor allele frequency- A:0.19EU EA WA 416
About this table

HapMap Linkage Disequilibrium images for ZBTB8OS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for ZBTB8OS gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 339487 HGNC: 24094 AceView: ARCH Ensembl:ENSG00000176261 euGenes: HUgn339487
ECgene: ZBTB8OS H-InvDB: ZBTB8OS
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ZBTB8OS:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB8OS-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for ZBTB8OS Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for ZBTB8OS Browse small molecules at Sigma-Aldrich
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