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Aliases for ZBTB8OS Gene

Aliases for ZBTB8OS Gene

  • Zinc Finger And BTB Domain Containing 8 Opposite Strand 2 3
  • Zinc Finger And BTB Domain-Containing Opposite Strand Protein 8 3 4
  • ARCH 3 4
  • Archease-Like Protein 3
  • Archease (ARCH) 3
  • Protein ZBTB8OS 4
  • Archease 2
  • ARCH2 3

External Ids for ZBTB8OS Gene

Previous GeneCards Identifiers for ZBTB8OS Gene

  • GC01M032735
  • GC01M032838
  • GC01M033065
  • GC01M031202

Summaries for ZBTB8OS Gene

GeneCards Summary for ZBTB8OS Gene

ZBTB8OS (Zinc Finger And BTB Domain Containing 8 Opposite Strand) is a Protein Coding gene. Diseases associated with ZBTB8OS include benign perivascular tumor and cardiovascular organ benign neoplasm. Among its related pathways are Gene Expression and tRNA modification in the nucleus and cytosol.

UniProtKB/Swiss-Prot for ZBTB8OS Gene

  • Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB8OS Gene

Genomics for ZBTB8OS Gene

Regulatory Elements for ZBTB8OS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBTB8OS Gene

Chromosome:
1
Start:
32,600,172 bp from pter
End:
32,651,013 bp from pter
Size:
50,842 bases
Orientation:
Minus strand

Genomic View for ZBTB8OS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB8OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB8OS Gene

Proteins for ZBTB8OS Gene

  • Protein details for ZBTB8OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWT0-ARCH_HUMAN
    Recommended name:
    Protein archease
    Protein Accession:
    Q8IWT0
    Secondary Accessions:
    • Q5TGK5
    • Q6PDA1
    • Q8IWS9
    • Q8NEV6
    • Q8NEV7

    Protein attributes for ZBTB8OS Gene

    Size:
    167 amino acids
    Molecular mass:
    19491 Da
    Quaternary structure:
    • Component of the tRNA-splicing ligase complex.
    SequenceCaution:
    • Sequence=AAM34477.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN75223.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN75224.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20020.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20021.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBTB8OS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB8OS Gene

Proteomics data for ZBTB8OS Gene at MOPED

Post-translational modifications for ZBTB8OS Gene

  • Ubiquitination at Lys 112
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZBTB8OS Gene

Domains & Families for ZBTB8OS Gene

Protein Domains for ZBTB8OS Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWT0

UniProtKB/Swiss-Prot:

ARCH_HUMAN :
  • Belongs to the archease family.
Family:
  • Belongs to the archease family.
genes like me logo Genes that share domains with ZBTB8OS: view

No data available for Gene Families for ZBTB8OS Gene

Function for ZBTB8OS Gene

Molecular function for ZBTB8OS Gene

UniProtKB/Swiss-Prot Function:
Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.

Gene Ontology (GO) - Molecular Function for ZBTB8OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB8OS: view

Phenotypes for ZBTB8OS Gene

genes like me logo Genes that share phenotypes with ZBTB8OS: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB8OS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB8OS Gene

Localization for ZBTB8OS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB8OS Gene COMPARTMENTS Subcellular localization image for ZBTB8OS gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for ZBTB8OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0070062 extracellular exosome IDA 23376485
GO:0072669 tRNA-splicing ligase complex IDA 24870230
genes like me logo Genes that share ontologies with ZBTB8OS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZBTB8OS Gene

Pathways & Interactions for ZBTB8OS Gene

genes like me logo Genes that share pathways with ZBTB8OS: view

Pathways by source for ZBTB8OS Gene

3 Reactome pathways for ZBTB8OS Gene

Interacting Proteins for ZBTB8OS Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000417677%0d%0a9606.ENSP00000216038%0d%0a9606.ENSP00000380734%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000329127%0d%0a
Selected Interacting proteins: Q8IWT0-ARCH_HUMAN ENSP00000417677 for ZBTB8OS Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ZBTB8OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation IDA 24870230
GO:0008033 tRNA processing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with ZBTB8OS: view

No data available for SIGNOR curated interactions for ZBTB8OS Gene

Drugs & Compounds for ZBTB8OS Gene

No Compound Related Data Available

Transcripts for ZBTB8OS Gene

Unigene Clusters for ZBTB8OS Gene

Zinc finger and BTB domain containing 8 opposite strand:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB8OS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8OS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: -
SP3: - - -
SP4: - -
SP5: - - - - - - - -
SP6:

Relevant External Links for ZBTB8OS Gene

GeneLoc Exon Structure for
ZBTB8OS
ECgene alternative splicing isoforms for
ZBTB8OS

Expression for ZBTB8OS Gene

mRNA expression in normal human tissues for ZBTB8OS Gene

Protein differential expression in normal tissues from HIPED for ZBTB8OS Gene

This gene is overexpressed in Tlymphocyte (8.2), Monocytes (8.0), and Oral epithelium (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB8OS Gene



SOURCE GeneReport for Unigene cluster for ZBTB8OS Gene Hs.655921

genes like me logo Genes that share expression patterns with ZBTB8OS: view

Protein tissue co-expression partners for ZBTB8OS Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB8OS Gene

Orthologs for ZBTB8OS Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB8OS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBTB8OS 35
  • 92.33 (n)
  • 95.68 (a)
ZBTB8OS 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB8OS 35
  • 94.6 (n)
  • 94.97 (a)
ZBTB8OS 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb8os 35
  • 89.62 (n)
  • 95.81 (a)
Zbtb8os 16
Zbtb8os 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBTB8OS 35
  • 99.63 (n)
  • 99.44 (a)
rat
(Rattus norvegicus)
Mammalia Zbtb8os 35
  • 89.57 (n)
  • 95.51 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB8OS 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB8OS 35
  • 78.83 (n)
  • 86.16 (a)
ZBTB8OS 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB8OS 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17752 35
zbtb8os 35
  • 74.33 (n)
  • 80.75 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.10898 35
zbtb8os 35
  • 71.28 (n)
  • 76.1 (a)
zbtb8os 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001976 35
  • 58.7 (n)
  • 61.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6353 35
  • 59.66 (n)
  • 60.14 (a)
CG6353 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C43H8.1 35
  • 55.88 (n)
  • 48.2 (a)
C43H8.1 36
  • 43 (a)
OneToOne
Species with no ortholog for ZBTB8OS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZBTB8OS Gene

ENSEMBL:
Gene Tree for ZBTB8OS (if available)
TreeFam:
Gene Tree for ZBTB8OS (if available)

Paralogs for ZBTB8OS Gene

(1) SIMAP similar genes for ZBTB8OS Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZBTB8OS Gene

genes like me logo Genes that share paralogs with ZBTB8OS: view

No data available for Paralogs for ZBTB8OS Gene

Variants for ZBTB8OS Gene

Sequence variations from dbSNP and Humsavar for ZBTB8OS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14319 -- 32,644,177(-) TATCA(C/T)CTTGT intron-variant
rs377397 -- 32,639,362(+) agtgg(C/G/T)tagtc intron-variant
rs377742 -- 32,632,867(-) ATGTC(A/G)TCCTC intron-variant, utr-variant-3-prime
rs385698 -- 32,622,999(-) TATCA(G/T)AGACG intron-variant
rs399378 -- 32,633,364(-) ttttg(G/T)ttttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB8OS Gene

Variant ID Type Subtype PubMed ID
nsv461039 CNV Loss 19166990
nsv519188 CNV Loss 19592680
esv2667534 CNV Deletion 23128226
esv2746519 CNV Deletion 23290073

Variation tolerance for ZBTB8OS Gene

Residual Variation Intolerance Score: 60.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB8OS Gene

HapMap Linkage Disequilibrium report
ZBTB8OS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB8OS Gene

Disorders for ZBTB8OS Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZBTB8OS Gene - From: DISEASES

Disorder Aliases PubMed IDs
benign perivascular tumor
  • benign pericytic neoplasm
cardiovascular organ benign neoplasm
glomangioma
  • glomus tumor
- elite association

Relevant External Links for ZBTB8OS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB8OS
genes like me logo Genes that share disorders with ZBTB8OS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB8OS Gene

Publications for ZBTB8OS Gene

  1. Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. (PMID: 24870230) Popow J. … Martinez J. (Nature 2014) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. (PMID: 25378478) Jurkin J. … Martinez J. (EMBO J. 2014) 67
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67

Products for ZBTB8OS Gene

Sources for ZBTB8OS Gene

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