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Aliases for ZBTB8B Gene

Aliases for ZBTB8B Gene

  • Zinc Finger And BTB Domain Containing 8B 2 3 5
  • Putative Zinc Finger And BTB Domain-Containing Protein 8B 3
  • Zinc Finger And BTB Domain-Containing Protein 8B 3
  • ZNF916B 3

External Ids for ZBTB8B Gene

Previous GeneCards Identifiers for ZBTB8B Gene

  • GC01P032694
  • GC01P032930
  • GC01P031046

Summaries for ZBTB8B Gene

GeneCards Summary for ZBTB8B Gene

ZBTB8B (Zinc Finger And BTB Domain Containing 8B) is a Protein Coding gene. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for ZBTB8B Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB8B Gene

Genomics for ZBTB8B Gene

Regulatory Elements for ZBTB8B Gene

Enhancers for ZBTB8B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZBTB8B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB8B Gene

Chromosome:
1
Start:
32,465,057 bp from pter
End:
32,496,686 bp from pter
Size:
31,630 bases
Orientation:
Plus strand

Genomic View for ZBTB8B Gene

Genes around ZBTB8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB8B Gene

Proteins for ZBTB8B Gene

  • Protein details for ZBTB8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAP8-ZBT8B_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 8B
    Protein Accession:
    Q8NAP8
    Secondary Accessions:
    • Q15DG5
    • Q5VXR5
    • Q69YT7

    Protein attributes for ZBTB8B Gene

    Size:
    495 amino acids
    Molecular mass:
    54175 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB8B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB8B Gene

Post-translational modifications for ZBTB8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB8B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB8B Gene

Domains & Families for ZBTB8B Gene

Gene Families for ZBTB8B Gene

Protein Domains for ZBTB8B Gene

Suggested Antigen Peptide Sequences for ZBTB8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NAP8

UniProtKB/Swiss-Prot:

ZBT8B_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 2 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB8B: view

Function for ZBTB8B Gene

Molecular function for ZBTB8B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB8B: view

Phenotypes for ZBTB8B Gene

GenomeRNAi human phenotypes for ZBTB8B:
genes like me logo Genes that share phenotypes with ZBTB8B: view

Animal Model Products

CRISPR Products

miRNA for ZBTB8B Gene

miRTarBase miRNAs that target ZBTB8B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB8B Gene

Localization for ZBTB8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB8B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB8B Gene COMPARTMENTS Subcellular localization image for ZBTB8B gene
Compartment Confidence
nucleus 5
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZBTB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB8B: view

Pathways & Interactions for ZBTB8B Gene

SuperPathways for ZBTB8B Gene

No Data Available

Interacting Proteins for ZBTB8B Gene

Selected Interacting proteins: Q8NAP8-ZBT8B_HUMAN for ZBTB8B Gene via IID

Gene Ontology (GO) - Biological Process for ZBTB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB8B: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB8B Gene

Drugs & Compounds for ZBTB8B Gene

No Compound Related Data Available

Transcripts for ZBTB8B Gene

mRNA/cDNA for ZBTB8B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB8B Gene

Zinc finger and BTB domain containing 8B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8B Gene

No ASD Table

Relevant External Links for ZBTB8B Gene

GeneLoc Exon Structure for
ZBTB8B
ECgene alternative splicing isoforms for
ZBTB8B

Expression for ZBTB8B Gene

mRNA expression in normal human tissues for ZBTB8B Gene

mRNA expression in normal human tissues for ZBTB8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB8B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB8B Gene



Protein tissue co-expression partners for ZBTB8B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB8B Gene:

ZBTB8B

SOURCE GeneReport for Unigene cluster for ZBTB8B Gene:

Hs.647658
genes like me logo Genes that share expression patterns with ZBTB8B: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB8B Gene

Orthologs for ZBTB8B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB8B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZBTB8B 34
  • 88.17 (n)
  • 89.25 (a)
-- 35
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zbtb8b 34
  • 81.54 (n)
  • 84.5 (a)
Zbtb8b 16
Zbtb8b 35
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZBTB8B 34
  • 99.53 (n)
  • 99.6 (a)
-- 35
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zbtb8b 34
  • 82.3 (n)
  • 85.48 (a)
cow
(Bos Taurus)
Mammalia -- 35
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZBTB8B 34
  • 75.19 (n)
  • 76.68 (a)
ZBTB8B 35
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb8b 34
  • 64.97 (n)
  • 63.06 (a)
zebrafish
(Danio rerio)
Actinopterygii zbtb8b 35
  • 48 (a)
OneToMany
Species where no ortholog for ZBTB8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB8B Gene

ENSEMBL:
Gene Tree for ZBTB8B (if available)
TreeFam:
Gene Tree for ZBTB8B (if available)

Paralogs for ZBTB8B Gene

(18) SIMAP similar genes for ZBTB8B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB8B: view

Variants for ZBTB8B Gene

Sequence variations from dbSNP and Humsavar for ZBTB8B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035602 A colorectal cancer sample
rs1112588 -- 32,464,185(+) CATGA(A/G)GATGG upstream-variant-2KB
rs1338383 -- 32,485,961(-) AATTG(G/T)TCTAG utr-variant-3-prime
rs1890343 -- 32,474,742(-) CAAAG(A/G)CATGG intron-variant
rs1809789 -- 32,483,279(-) cctgg(C/G)taaat intron-variant

Variation tolerance for ZBTB8B Gene

Gene Damage Index Score: 1.32; 26.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB8B Gene

Disorders for ZBTB8B Gene

Relevant External Links for ZBTB8B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB8B

No disorders were found for ZBTB8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB8B Gene

Publications for ZBTB8B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 65
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 65
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 65

Products for ZBTB8B Gene

Sources for ZBTB8B Gene

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