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Aliases for ZBTB8A Gene

Aliases for ZBTB8A Gene

  • Zinc Finger And BTB Domain Containing 8A 2 3
  • BTB/POZ And Zinc-Finger Domains Factor On Chromosome 1 3 4
  • BTB/POZ And Zinc-Finger Domain-Containing Factor 3 4
  • Zinc Finger And BTB Domain Containing 8 2 3
  • BOZF1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 8A 3
  • ZNF916A 3
  • BOZ-F1 4
  • ZBTB8 3

External Ids for ZBTB8A Gene

Previous HGNC Symbols for ZBTB8A Gene

  • ZBTB8

Previous GeneCards Identifiers for ZBTB8A Gene

  • GC01P032779
  • GC01P032931
  • GC01P031119
  • GC01P033004

Summaries for ZBTB8A Gene

GeneCards Summary for ZBTB8A Gene

ZBTB8A (Zinc Finger And BTB Domain Containing 8A) is a Protein Coding gene. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for ZBTB8A Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB8A Gene

Genomics for ZBTB8A Gene

Regulatory Elements for ZBTB8A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBTB8A Gene

Start:
32,539,171 bp from pter
End:
32,605,941 bp from pter
Size:
66,771 bases
Orientation:
Plus strand

Genomic View for ZBTB8A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB8A Gene

Proteins for ZBTB8A Gene

  • Protein details for ZBTB8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BR9-ZBT8A_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 8A
    Protein Accession:
    Q96BR9
    Secondary Accessions:
    • Q8IUL5
    • Q8IWR9
    • Q8N2Y5
    • Q96BX0

    Protein attributes for ZBTB8A Gene

    Size:
    441 amino acids
    Molecular mass:
    50141 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB8A Gene

Proteomics data for ZBTB8A Gene at MOPED

Post-translational modifications for ZBTB8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB8A Gene

Domains for ZBTB8A Gene

Gene Families for ZBTB8A Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZBTB8A Gene

Suggested Antigen Peptide Sequences for ZBTB8A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BR9

UniProtKB/Swiss-Prot:

ZBT8A_HUMAN :
  • Q96BR9
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB8A: view

Function for ZBTB8A Gene

Molecular function for ZBTB8A Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZBTB8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB8A: view

Phenotypes for ZBTB8A Gene

genes like me logo Genes that share phenotypes with ZBTB8A: view

Animal Model Products

CRISPR Products

miRNA for ZBTB8A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB8A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB8A Gene

Localization for ZBTB8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB8A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB8A Gene COMPARTMENTS Subcellular localization image for ZBTB8A gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZBTB8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB8A: view

Pathways for ZBTB8A Gene

SuperPathways for ZBTB8A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZBTB8A: view

No data available for Pathways by source for ZBTB8A Gene

Transcripts for ZBTB8A Gene

mRNA/cDNA for ZBTB8A Gene

(6) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB8A Gene

Zinc finger and BTB domain containing 8A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB8A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for ZBTB8A Gene

GeneLoc Exon Structure for
ZBTB8A
ECgene alternative splicing isoforms for
ZBTB8A

Expression for ZBTB8A Gene

mRNA expression in normal human tissues for ZBTB8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZBTB8A Gene

SOURCE GeneReport for Unigene cluster for ZBTB8A Gene Hs.546479

genes like me logo Genes that share expressions with ZBTB8A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB8A Gene

Orthologs for ZBTB8A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB8A 35
  • 99.55 (n)
  • 99.32 (a)
ZBTB8A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB8A 35
  • 91.08 (n)
  • 94.78 (a)
ZBTB8A 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB8A 35
  • 91.21 (n)
  • 94.77 (a)
ZBTB8A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb8a 35
  • 80.41 (n)
  • 82.95 (a)
Zbtb8a 16
Zbtb8a 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB8A 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB8A 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb8a 35
  • 81.24 (n)
  • 85.17 (a)
chicken
(Gallus gallus)
Aves ZBTB8A 35
  • 74.79 (n)
  • 79.5 (a)
ZBTB8A 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB8A 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb8a.1 35
  • 60.43 (n)
  • 57.31 (a)
zebrafish
(Danio rerio)
Actinopterygii ZBTB8A 36
  • 44 (a)
OneToOne
zgc:136874 35
  • 52.44 (n)
  • 51.77 (a)
Species with no ortholog for ZBTB8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB8A Gene

ENSEMBL:
Gene Tree for ZBTB8A (if available)
TreeFam:
Gene Tree for ZBTB8A (if available)

Paralogs for ZBTB8A Gene

Selected SIMAP similar genes for ZBTB8A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZBTB8A: view

Variants for ZBTB8A Gene

Sequence variations from dbSNP and Humsavar for ZBTB8A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs367853 -- 32,606,350(-) gttcc(C/T)ggcat downstream-variant-500B
rs420993 -- 32,605,145(+) actcc(A/C)tcaaa utr-variant-3-prime, nc-transcript-variant
rs422215 -- 32,603,153(-) AGTCC(A/G)TCTCA utr-variant-3-prime, nc-transcript-variant
rs428100 -- 32,598,427(+) agatg(C/G)agttt intron-variant
rs432974 -- 32,604,922(-) ccgcc(C/T)gcctc utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB8A Gene

Variant ID Type Subtype PubMed ID
esv2666068 CNV Deletion 23128226
nsv461039 CNV Loss 19166990
esv2746508 CNV Deletion 23290073
esv2576617 CNV Insertion 19546169
nsv512732 CNV Insertion 21212237
esv1277305 CNV Insertion 17803354
esv2671633 CNV Deletion 23128226

Relevant External Links for ZBTB8A Gene

HapMap Linkage Disequilibrium report
ZBTB8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB8A Gene

Disorders for ZBTB8A Gene

Relevant External Links for ZBTB8A

Genetic Association Database (GAD)
ZBTB8A
Human Genome Epidemiology (HuGE) Navigator
ZBTB8A
genes like me logo Genes that share disorders with ZBTB8A: view

No data available for UniProtKB/Swiss-Prot for ZBTB8A Gene

Publications for ZBTB8A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding. (PMID: 23329847) Kim M.K. … Hur M.W. (J. Biol. Chem. 2013) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for ZBTB8A Gene

Sources for ZBTB8A Gene

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