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Aliases for ZBTB8A Gene

Aliases for ZBTB8A Gene

  • Zinc Finger And BTB Domain Containing 8A 2 3 5
  • BTB/POZ And Zinc-Finger Domains Factor On Chromosome 1 3 4
  • BTB/POZ And Zinc-Finger Domain-Containing Factor 3 4
  • Zinc Finger And BTB Domain Containing 8 2 3
  • BOZF1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 8A 3
  • ZNF916A 3
  • BOZ-F1 4
  • ZBTB8 3

External Ids for ZBTB8A Gene

Previous HGNC Symbols for ZBTB8A Gene

  • ZBTB8

Previous GeneCards Identifiers for ZBTB8A Gene

  • GC01P032779
  • GC01P032931
  • GC01P031119
  • GC01P033004

Summaries for ZBTB8A Gene

GeneCards Summary for ZBTB8A Gene

ZBTB8A (Zinc Finger And BTB Domain Containing 8A) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBTB8B.

UniProtKB/Swiss-Prot for ZBTB8A Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB8A Gene

Genomics for ZBTB8A Gene

Regulatory Elements for ZBTB8A Gene

Enhancers for ZBTB8A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G032496 1 Ensembl ENCODE 11.2 -42.9 -42862 0.6 HDGF PKNOX1 ETV1 BMI1 CEBPG ZBTB40 IRF9 ZNF766 PRDM10 ZNF362 ZBTB8B ENSG00000254553 ZBTB8A ENSG00000224409 RBBP4 ZBTB8OS LOC105378629 FNDC5 GC01P032498
GH01G032636 0.9 Ensembl ENCODE 11.2 +98.1 98105 2.0 MAFG MNT ZNF394 FOXA1 ZNF316 KLF9 NFE2 EMSY NFE2L2 TCF7L2 SYNC ZBTB8A FNDC5 RBBP4 GC01P032641 GC01M032619
GH01G032626 0.8 ENCODE 11.1 +88.7 88749 2.2 CTCF BCOR PKNOX1 ZMYM3 POLR2A EED ZNF207 RELB IKZF2 CREM SYNC RBBP4 ZBTB8OS ZBTB8A ENSG00000224066 EIF3I TMEM234 DCDC2B GC01M032619 LOC102723870
GH01G032493 0.8 ENCODE 11 -46.5 -46524 0.1 HINFP ZNF175 FOSL1 TCF12 EGR1 NCOR1 NR2F6 TRIM24 HES1 SMARCE1 ZBTB8B ENSG00000254553 ZBTB8A RBBP4 ZBTB8OS LOC105378629 FNDC5 GC01P032498
GH01G032494 0.8 ENCODE 11 -44.8 -44769 1.7 SOX13 PKNOX1 ATF1 TAL1 CEBPG TCF12 ZFHX2 NCOR1 TRIM24 PRDM10 ENSG00000254553 ZBTB8B ZBTB8A ZBTB8OS RBBP4 LOC105378629 FNDC5 TSSK3 GC01P032498
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB8A on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB8A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004379 555 1401 HDGF SIN3A ZBTB7B GLIS2 GATA2 FOS SP3 MAFF CBX8 SP7

Genomic Location for ZBTB8A Gene

Chromosome:
1
Start:
32,539,145 bp from pter
End:
32,605,950 bp from pter
Size:
66,806 bases
Orientation:
Plus strand

Genomic View for ZBTB8A Gene

Genes around ZBTB8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB8A Gene

Proteins for ZBTB8A Gene

  • Protein details for ZBTB8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BR9-ZBT8A_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 8A
    Protein Accession:
    Q96BR9
    Secondary Accessions:
    • Q8IUL5
    • Q8IWR9
    • Q8N2Y5
    • Q96BX0

    Protein attributes for ZBTB8A Gene

    Size:
    441 amino acids
    Molecular mass:
    50141 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB8A Gene

Post-translational modifications for ZBTB8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB8A Gene

Domains & Families for ZBTB8A Gene

Gene Families for ZBTB8A Gene

Protein Domains for ZBTB8A Gene

Suggested Antigen Peptide Sequences for ZBTB8A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB8A: view

No data available for UniProtKB/Swiss-Prot for ZBTB8A Gene

Function for ZBTB8A Gene

Molecular function for ZBTB8A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB8A: view
genes like me logo Genes that share phenotypes with ZBTB8A: view

Animal Model Products

CRISPR Products

miRNA for ZBTB8A Gene

miRTarBase miRNAs that target ZBTB8A

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB8A Gene

Localization for ZBTB8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB8A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB8A gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB8A: view

Pathways & Interactions for ZBTB8A Gene

SuperPathways for ZBTB8A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZBTB8A: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB8A Gene

Drugs & Compounds for ZBTB8A Gene

No Compound Related Data Available

Transcripts for ZBTB8A Gene

mRNA/cDNA for ZBTB8A Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB8A Gene

Zinc finger and BTB domain containing 8A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for ZBTB8A Gene

GeneLoc Exon Structure for
ZBTB8A
ECgene alternative splicing isoforms for
ZBTB8A

Expression for ZBTB8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB8A Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB8A Gene



Protein tissue co-expression partners for ZBTB8A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB8A Gene:

ZBTB8A

SOURCE GeneReport for Unigene cluster for ZBTB8A Gene:

Hs.546479

Evidence on tissue expression from TISSUES for ZBTB8A Gene

  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZBTB8A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB8A Gene

Orthologs for ZBTB8A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB8A 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia ZBTB8A 34 35
  • 91.21 (n)
cow
(Bos Taurus)
Mammalia ZBTB8A 34 35
  • 91.08 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb8a 34
  • 81.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB8A 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb8a 34 16 35
  • 80.41 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB8A 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB8A 34 35
  • 74.79 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB8A 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb8a.1 34
  • 60.43 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:136874 34
  • 52.44 (n)
ZBTB8A 35
  • 44 (a)
OneToOne
Species where no ortholog for ZBTB8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB8A Gene

ENSEMBL:
Gene Tree for ZBTB8A (if available)
TreeFam:
Gene Tree for ZBTB8A (if available)

Paralogs for ZBTB8A Gene

(6) SIMAP similar genes for ZBTB8A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZBTB8A: view

Variants for ZBTB8A Gene

Sequence variations from dbSNP and Humsavar for ZBTB8A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000012179 -- 32,567,960(+) CATGG(A/T)GAAAC intron-variant
rs1000051793 -- 32,553,674(+) CTGAG(G/T)TCGGG intron-variant
rs1000084799 -- 32,545,010(+) TGAAT(A/G)TATAC intron-variant
rs1000148468 -- 32,580,891(+) AGGGG(G/T)CCAAA intron-variant
rs1000149330 -- 32,540,164(+) CAACT(A/G)TTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB8A Gene

Variant ID Type Subtype PubMed ID
dgv72n106 CNV deletion 24896259
esv1277305 CNV insertion 17803354
esv2576617 CNV insertion 19546169
esv2666068 CNV deletion 23128226
esv2671633 CNV deletion 23128226
esv2746508 CNV deletion 23290073
esv3585672 CNV loss 21293372
esv3893501 CNV loss 25118596
nsv1005213 CNV gain 25217958
nsv1075804 CNV deletion 25765185
nsv461039 CNV loss 19166990
nsv475689 CNV novel sequence insertion 20440878
nsv512732 CNV insertion 21212237
nsv545960 CNV loss 21841781
nsv545961 CNV loss 21841781

Variation tolerance for ZBTB8A Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB8A Gene

Disorders for ZBTB8A Gene

Relevant External Links for ZBTB8A

Genetic Association Database (GAD)
ZBTB8A
Human Genome Epidemiology (HuGE) Navigator
ZBTB8A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB8A

No disorders were found for ZBTB8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB8A Gene

Publications for ZBTB8A Gene

  1. Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding. (PMID: 23329847) Kim M.K. … Hur M.W. (J. Biol. Chem. 2013) 2 3 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64

Products for ZBTB8A Gene

Sources for ZBTB8A Gene

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