ZBTB8A Gene
protein-coding GIFtS: 46
GCID: GC01P033004
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zinc finger and BTB domain containing 8A(Previous name: zinc finger and BTB domain containing 8 ) (Previous symbol: ZBTB8)
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Aliases for ZBTB8A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 8A1 2 | | BOZ-F12 3 | | BOZF11 2 3 | | BTB/POZ And Zinc-Finger Domain-Containing Factor2 3 | | ZBTB81 2 | | BTB/POZ And Zinc-Finger Domains Factor On Chromosome 12 3 | | ZNF916A1 2 | | FLJ900651 | | Zinc Finger And BTB Domain Containing 81 2 | | Zinc Finger And BTB Domain-Containing Protein 8A2 |
Export aliases for ZBTB8A gene to outside databasesPrevious GC identifers: GC01P032779 GC01P032931 GC01P031119 |
Summaries for ZBTB8A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZBT8A_HUMAN, Q96BR9Function: May be involved in transcriptional regulation
|
Genomic Views for ZBTB8A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZBTB8A gene promoter: GR HTF GR-beta AP-2gamma GATA-1 Egr-2 c-Rel c-Myb GR-alpha ATF6 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB8A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB8A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35.1 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p34.3ZBTB8A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P033004: view genomic region
(about GC identifiers)
Start:
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33,004,772 bp from pter |
End:
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33,071,542 bp from pter |
Size:
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66,771 bases |
Orientation:
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plus strand |
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Proteins for ZBTB8A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZBT8A_HUMAN, Q96BR9 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 8A Size: 441 amino acids; 50141 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q8IUL5 Q8IWR9 Q8N2Y5 Q96BX0Alternative splicing: 2 isoforms: Q96BR9-1 Q96BR9-2 Explore the universe of human proteins at neXtProt for ZBTB8A: NX_Q96BR9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96BR9 ZBTB8A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001035531.1 ENSEMBL proteins: ENSP00000362609 ENSP00000317561 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZBTB8A for ontologies About GeneDecksing
ZBTB8A Antibody Products: Assay Products for ZBTB8A: |
Protein
Domains / Families for ZBTB8A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB8A for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96BR9ProtoNet protein and cluster: Q96BR9 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT8A_HUMAN, Q96BR9Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 2 C2H2-type zinc fingers |
Function for ZBTB8A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZBT8A_HUMAN, Q96BR9Function: May be involved in transcriptional regulation
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB8A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB8A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZBTB8A (NM_001040441) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB8A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB8A  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB8A |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZBTB8A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZBTB8A:
|
Pathways & Interactions for ZBTB8A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB8A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
 5/27 Interacting proteins for ZBTB8A (Q96BR92, 3 ENSP000003626094) via UniProtKB, MINT, STRING, and/or I2D (see all 27)| Interactant | Interaction Details |
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| GeneCard | External ID(s) |
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| MYO15B | Q96JP22, 3, ENSP000002932014 | MINT-66590 I2D:
score=1 STRING: ENSP00000293201 | | CEP70 | Q8NHQ12, 3, ENSP000002649824 | MINT-67914 I2D:
score=3 STRING: ENSP00000264982 | | FXR2 | P511162, 3, ENSP000002501134 | MINT-66917 I2D:
score=3 STRING: ENSP00000250113 | | KAT7 | O952512, 3, ENSP000002590214 | MINT-66547 I2D:
score=3 STRING: ENSP00000259021 | | LNX1 | Q8TBB12, 3, ENSP000002639254 | MINT-66958 I2D:
score=3 STRING: ENSP00000263925 | About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
ZBTB8A for ontologies About GeneDecksing
|
Drugs & Compounds for ZBTB8A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZBTB8A Search CenterWatch for drugs/clinical trials and news about ZBTB8A / ZBT8A 
|
Transcripts for ZBTB8A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZBTB8A gene (2 alternative transcripts): NM_144621.2 NM_001040441.1 Unigene Cluster for ZBTB8A: Zinc finger and BTB domain containing 8A Hs.546479 [show with all ESTs]Unigene Representative Sequence: NM_0010404412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373510(uc001bvm.3) ENST00000316459(uc001bvn.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB8A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB8A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZBTB8A (NM_001040441) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB8A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB8A  |
Additional cDNA sequence: AF548353.1 AK074546.1 AY157873.1 BC015067.1 BC015239.1 BC029654.1 3 DOTS entries: DT.102938 DT.75140492 DT.40202280 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8 | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZBTB8A
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Expression for ZBTB8A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB8A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CTTTCTGAAC
About this image See ZBTB8A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZBTB8A
SOURCE GeneReport for Unigene cluster: Hs.546479 SABiosciences Custom PCR Arrays for ZBTB8A
Primer Products: |  | Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB8A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB8A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB8A | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB8A |
Orthologs for ZBTB8A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB8A gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for ZBTB8A (if available) TreeFam Gene Tree for ZBTB8A (if available)  |
Paralogs for ZBTB8A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZBTB8A gene
- ZBTB102 ZBTB32 ZBTB182 ENSG000002545532 ZBTB442 ZBTB52 ZBTB492 HIC12
- ZBTB242 MYNN2 HIC22 GZF12 ZBTB422 ZBTB462 ZBTB8B2 ZBTB172
6 SIMAP similar genes for ZBTB8A using alignment to 3 protein entries: ZBT8A_HUMAN (see all proteins):ZNF KBTBD3 ZNF78L1 KLHL32 DKFZp434J0650 ZBTB8B
ZBTB8A for paralogs About GeneDecksing
|
Genomic Variants for ZBTB8A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB8A (33004772 - 33071542 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for ZBTB8A 1 CNV: 84169 2 Indels: 84170 97329  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB8A |
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Disorders
/ Diseases for ZBTB8A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBTB8A for disorders About MalaCards
ZBTB8A for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZBTB8A (1 document) Export disorders for ZBTB8A gene to outside databases
|
Publications for ZBTB8A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB8A gene, integrated from 9 sources (see all 12): (articles sorted by number of sources associating them with ZBTB8A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)1 Sjoeblom T.... Velculescu V.E. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
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External Searches for ZBTB8A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZBTB8A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB8A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB8A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB8A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB8A gene: Search GeneIP for patents involving ZBTB8A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZBTB8A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBTB8A | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB8A | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB8A | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB8A | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB8A | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB8A |
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| | | Search Tocris compounds for ZBTB8A |
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 | | ZBTB8A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB8A |
|  |  |  | | | ThermoFisher Antibodies for ZBTB8A |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB8A |
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