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ZBTB8A Gene

protein-coding GIFtS: 43

GC01P032779

zinc finger and BTB domain containing 8A
(Previous name: zinc finger and BTB domain containing 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZBTB8)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BOZF1 ^¹, ²
FLJ90065 ^¹, ²
MGC17919 ^²
OTTHUMP00000009579 ^²
ZBTB8 ^², ⁴

Descriptions
BTB/POZ and zinc-finger domains factor on chromosome 1 ^²
HCG39683, isoform CRA_a ^⁴
HCG39683, isoform CRA_b ^⁴
Zinc finger and BTB domain containing 8 ^¹, ², ⁴
cDNA FLJ90065 fis, clone HEMBA1003497, weakly similar to ZINC FINGER PROTEIN 151 ^⁴
zinc finger and BTB domain containing 8A ^²

External Ids
HGNC: 24172¹
Entrez Gene: 653121²
UniProtKB: Q8IWR9⁴
UniProtKB: Q96BX0⁴
UniProtKB: Q96BR9⁴
UniProtKB: Q8N2Y5⁴
UniProtKB: Q8IUL5⁴
Ensembl: ENSG00000160062⁷

Search outside databases for aliases for ZBTB8A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p34.3

ZBTB8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P032779: (about GC identifiers)

Start:	32,777,359 bp from pter
End:	32,844,129 bp from pter
Size:	66,771 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/TrEMBL: Q8IWR9 (See protein sequence)

Recommended Name: BTB/POZ and zinc-finger domain containing factor variant L

Size: 340 amino acids; 38502 Da

UniProtKB/TrEMBL: Q96BX0 (See protein sequence)

Recommended Name: ZBTB8 protein

Size: 236 amino acids; 27148 Da

UniProtKB/TrEMBL: Q96BR9 (See protein sequence)

Recommended Name: Zinc finger and BTB domain containing 8

Size: 441 amino acids; 50155 Da

UniProtKB/TrEMBL: Q8N2Y5 (See protein sequence)

Recommended Name: ZBTB8 protein

Size: 251 amino acids; 28964 Da

UniProtKB/TrEMBL: Q8IUL5 (See protein sequence)

Recommended Name: BTB/POZ and zinc-finger domains factor on chromosome 1

Size: 441 amino acids; 50141 Da

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001035531.1

ENSEMBL proteins:

ENSP00000362609 ENSP00000317561

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZBTB8)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: ZBTB8A

Antibodies for ZBTB8A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZBTB8), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZBTB8A

Assays for ZBTB8A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8IWR9

Graphical View of Domain Structure for InterPro Entry Q96BX0

Graphical View of Domain Structure for InterPro Entry Q96BR9

Graphical View of Domain Structure for InterPro Entry Q8N2Y5

Graphical View of Domain Structure for InterPro Entry Q8IUL5

ProtoNet protein and cluster: Q8IWR9

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/TrEMBL: Q8IWR9

Similarity: Contains 1 BTB (POZ) domain

UniProtKB/TrEMBL: Q96BR9

Similarity: Contains 1 BTB (POZ) domain

UniProtKB/TrEMBL: Q8IUL5

Similarity: Contains 1 BTB (POZ) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001040441

Applied Biosystems Silencer® siRNAs for ZBTB8A

Sigma-Aldrich siRNA and siRNA Panels for ZBTB8A

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZBTB8A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001040441
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001040441
untagged cDNA clones in CMV expression vector (see all 2): BC015239

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC015239

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/18 Interacting proteins for ZBTB8A (Q8IWR9²) via UniProtKB, MINT, and/or STRING (see all 18 )
Interactant Interaction Details
GeneCard External ID(s)
AP1M1 Q9BXS5² MINT-68134
AP2M1 Q96CW1² MINT-66873
CEP70 Q8NHQ1² MINT-67914
DVL2 O14641² MINT-67491
FXR2 P51116² MINT-66917
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB8A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001040441

Sigma-Aldrich siRNA and siRNA Panels for ZBTB8A

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001040441

REFSEQ mRNAs for ZBTB8A gene:

NM_001040441.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001040441

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001040441
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001040441
                                 untagged cDNA clones in CMV expression vector (see all 2): BC015239

Additional cDNA sequence:

AF548353.1 AK074546.1 AY157873.1 BC015067.1 BC015239.1 BC029654.1

3 DOTS entries:

DT.102938 DT.75140492 DT.40202280

Unigene Cluster for ZBTB8A:

Zinc finger and BTB domain containing 8A

Hs.546479 [show with all ESTs]

Unigene Representative Sequence: NM_001040441

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB8A

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8
SP1:											-
SP2:													-
SP3:											-		-
SP4:

About this scheme

ECgene alternative splicing isoforms for ZBTB8A

2 Ensembl transcripts including schematic representations:

ENST00000373510 ENST00000316459

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB8A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB8A

¹ / ²

3 probe-sets matching ZBTB8A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
74507_at²	U95-E	1	0.94	1.00	1.00	1.00	--	--	--	--	--
235142_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
235142_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTTCTGAAC

SOURCE GeneReport for Unigene cluster: Hs.546479

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBTB8A gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBTB8¹	--	zinc finger and BTB domain containing 8	91.21(n) 94.77(a)	487304 XM_544430.2 XP_544430.2
cow (Bos taurus)	ZBTB8¹	--	zinc finger and BTB domain containing 8	91.08(n) 94.78(a)	541221 NM_001076264.1 NP_001069732.1
rat (Rattus norvegicus)	Zbtb8a¹	--	zinc finger and BTB domain containing 8a	82.16(n) 86.62(a)	313049 XM_232766.3 XP_232766.3
mouse (Mus musculus)	Zbtb8a^{1, 5}	4⁵	zinc finger and BTB domain containing 8a^{1, 5}	81.95(n)¹ 84.56(a)¹	73680¹ NM_028603.2¹ NP_082879.1¹ AA399878⁵ AI480941⁵ (see all 10)
chicken (Gallus gallus)	ZBTB8¹	--	zinc finger and BTB domain containing 8	74.79(n) 79.5(a)	419661 XM_417808.2 XP_417808.2

About this table Species with no ortholog for ZBTB8A

ENSEMBL Gene Tree for ZBTB8A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB8A gene

BCL6B² BCL6² ENSG00000215897²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/303 NCBI SNPs in ZBTB8A are shown (see all 303 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 63)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2294815^1,2	A,C,F,H,O	32838886(-)	`CTCTGG/TAATAA`	1	--	ut3¹		12		EA EU WA NA	2440
	rs704885^1,2	A,C,F,H,O	32839178(+)	`CTAAAG/ATGTTT`	1	--	ut3¹ ese³		17		NA EA EU WA	1482
	rs12567940^1,2	A,C,F,H	32840089(+)	`TGTCAC/AGTTAT`	1	--	ut3¹		4		EU EA WA	418
	rs422215^1,2	A,C,F,H	32841341(-)	`agtccG/Atctca`	1	--	ut3¹		4		EU EA WA	418
	rs2095761^1,2	A,C,F,H	32776597(+)	`ACACCA/TGACAC`	1	--	ng5¹		4		EU EA WA	416
	rs704886^1,2	A,C,F,H	32838534(-)	`GATCAG/CCAGAC`	1	A/G	mis¹		11		NA EA MN EU WA	1030
--	rs9662044^1,2	A,C	32776323(+)	`tgttgG/Tccagg`	1	--	ng5¹		0	--	--	--	--
--	rs367853^1,2	F,H	32844538(-)	`gttccC/Tggcat`	1	--	ng3¹		4		EU EA WA	412
	rs12136921^1,2	F,H	32843365(+)	`GATGTG/ATTTAA`	1	--	ut3¹		3		EU EA	290
	rs12086054^1,2	H	32844183(+)	`agccaG/Aaaacc`	1	--	ng3¹		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for ZBTB8A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for ZBTB8A gene:

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)³ Sjoeblom T.... Velculescu V.E. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)³ Gregory S.G.... Bentley D.R. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 653121	HGNC: 24172	Ensembl:ENSG00000160062	euGenes: HUgn653121	ECgene: ZBTB8A
H-InvDB: ZBTB8A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBTB8A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ZBTB8A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB8A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB8A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
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	shRNA in GFP-retroviral vector

Search Tocris compounds for ZBTB8A

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ZBTB8A Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for ZBTB8A

Summaries
for ZBTB8A

Genomic Location
for ZBTB8A

Proteins
for ZBTB8A

Protein Domains/
Families
for ZBTB8A

Gene Function
for ZBTB8A

Pathways & Interactions
for ZBTB8A

Drugs & Compounds
for ZBTB8A

Transcripts
for ZBTB8A

Expression
for ZBTB8A

Orthologs
for ZBTB8A

Paralogs
for ZBTB8A

SNPs/Variants
for ZBTB8A

Disorders & Mutations
for ZBTB8A

Medical News
for ZBTB8A

Publications
for ZBTB8A

Search for ZBTB8A

Genome Databases showing ZBTB8A

Other Databases showing ZBTB8A

Specialized Databases showing ZBTB8A

Licensable Technologies
for ZBTB8A

Services
for ZBTB8A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB8A Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor ZBTB8A

Summariesfor ZBTB8A

Genomic Locationfor ZBTB8A

Proteinsfor ZBTB8A

Protein Domains/Familiesfor ZBTB8A

Gene Functionfor ZBTB8A

Pathways & Interactionsfor ZBTB8A

Drugs & Compoundsfor ZBTB8A

Transcriptsfor ZBTB8A

Expression for ZBTB8A

Orthologsfor ZBTB8A

Paralogsfor ZBTB8A

SNPs/Variantsfor ZBTB8A

Disorders & Mutationsfor ZBTB8A

Medical Newsfor ZBTB8A

Publicationsfor ZBTB8A

Search for ZBTB8A

Genome Databases showing ZBTB8A

Other Databases showing ZBTB8A

Specialized Databases showing ZBTB8A

Licensable Technologiesfor ZBTB8A

Servicesfor ZBTB8A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB8A

Summaries
for ZBTB8A

Genomic Location
for ZBTB8A

Proteins
for ZBTB8A

Protein Domains/
Families
for ZBTB8A

Gene Function
for ZBTB8A

Pathways & Interactions
for ZBTB8A

Drugs & Compounds
for ZBTB8A

Transcripts
for ZBTB8A

Expression
for ZBTB8A

Orthologs
for ZBTB8A

Paralogs
for ZBTB8A

SNPs/Variants
for ZBTB8A

Disorders & Mutations
for ZBTB8A

Medical News
for ZBTB8A

Publications
for ZBTB8A

Licensable Technologies
for ZBTB8A

Services
for ZBTB8A