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Aliases for ZBTB7C Gene

Aliases for ZBTB7C Gene

  • Zinc Finger And BTB Domain Containing 7C 2 3 5
  • Affected By Papillomavirus DNA Integration In ME180 Cells Protein 1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 36 3 4
  • Zinc Finger And BTB Domain Containing 36 2 3
  • Zinc Finger Protein 857C 3 4
  • ZNF857C 3 4
  • ZBTB36 3 4
  • APM-1 3 4
  • APM1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 7C 3
  • B230208J24Rik 3

External Ids for ZBTB7C Gene

Previous HGNC Symbols for ZBTB7C Gene

  • ZBTB36

Previous GeneCards Identifiers for ZBTB7C Gene

  • GC00U921557
  • GC18U900235
  • GC18M043811
  • GC18M045553
  • GC18M042403

Summaries for ZBTB7C Gene

GeneCards Summary for ZBTB7C Gene

ZBTB7C (Zinc Finger And BTB Domain Containing 7C) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBTB7A.

UniProtKB/Swiss-Prot for ZBTB7C Gene

  • May be a tumor suppressor gene.

Additional gene information for ZBTB7C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB7C Gene

Genomics for ZBTB7C Gene

Regulatory Elements for ZBTB7C Gene

Enhancers for ZBTB7C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H048452 1.4 Ensembl ENCODE dbSUPER 16.2 -43.7 -43748 5 ELF3 TBP MLX ARID4B RARA YY1 SCRT2 FOS CREM MIXL1 ZBTB7C CTIF RNA5SP456 GC18M048476
GH18H048872 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -462.8 -462812 2 ZNF493 ZFP64 FEZF1 ZNF48 ZNF121 GLIS2 KLF7 ZNF548 FOS ZNF202 RPL17 ENSG00000264269 ENSG00000266696 LOC105372107 ENSG00000265128 ENSG00000263895 LOC101928144 SRP72P1 SMAD2 CTIF
GH18H049019 1.6 Ensembl ENCODE dbSUPER 10.5 -610.4 -610447 3.1 HDGF ARID4B SIN3A YBX1 ZNF2 SLC30A9 ZNF416 ZNF207 ZNF143 FOS RPL17 ENSG00000264269 DYM ZBTB7C LOC105372109
GH18H048410 0.9 ENCODE 10.8 +0.5 451 1.4 PKNOX1 GLIS2 EGR1 EGR2 SP3 NFYC ZEB2 ZNF398 SP1 CBX8 ZBTB7C C18orf12
GH18H048812 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.2 -403.9 -403918 4.5 LEF1 KLF1 ATF1 CEBPG BATF RELA POLR2A FOXK2 EED PRDM10 SMAD7 ZBTB7C LOC105372106 LOC105372105
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB7C on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB7C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000103034 1052 1801 PKNOX1 GLIS2 EGR1 SCRT2 EGR2 SP3 NFYC ZEB2 SP1 KLF16

Transcription factor binding sites by QIAGEN in the ZBTB7C gene promoter:

Genomic Locations for ZBTB7C Gene

Genomic Locations for ZBTB7C Gene
384,080 bases
Minus strand

Genomic View for ZBTB7C Gene

Genes around ZBTB7C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB7C Gene

Proteins for ZBTB7C Gene

  • Protein details for ZBTB7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 7C
    Protein Accession:
    Secondary Accessions:
    • O73453

    Protein attributes for ZBTB7C Gene

    619 amino acids
    Molecular mass:
    69017 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB7C Gene

Post-translational modifications for ZBTB7C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB7C Gene

Domains & Families for ZBTB7C Gene

Gene Families for ZBTB7C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB7C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB7C: view

No data available for UniProtKB/Swiss-Prot for ZBTB7C Gene

Function for ZBTB7C Gene

Molecular function for ZBTB7C Gene

UniProtKB/Swiss-Prot Function:
May be a tumor suppressor gene.

Phenotypes From GWAS Catalog for ZBTB7C Gene

Gene Ontology (GO) - Molecular Function for ZBTB7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB7C: view

Phenotypes for ZBTB7C Gene

genes like me logo Genes that share phenotypes with ZBTB7C: view

Animal Models for ZBTB7C Gene

MGI Knock Outs for ZBTB7C:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB7C Gene

Localization for ZBTB7C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB7C gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB7C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ZBTB7C Gene

Pathways & Interactions for ZBTB7C Gene

SuperPathways for ZBTB7C Gene

No Data Available

Interacting Proteins for ZBTB7C Gene

Gene Ontology (GO) - Biological Process for ZBTB7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 9427755
GO:0045600 positive regulation of fat cell differentiation IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ZBTB7C: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB7C Gene

Drugs & Compounds for ZBTB7C Gene

No Compound Related Data Available

Transcripts for ZBTB7C Gene

mRNA/cDNA for ZBTB7C Gene

(17) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(28) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB7C Gene

Zinc finger and BTB domain containing 7C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7C Gene

No ASD Table

Relevant External Links for ZBTB7C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB7C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB7C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB7C Gene

This gene is overexpressed in Esophagus - Mucosa (x7.5) and Skin - Sun Exposed (Lower leg) (x4.2).

Protein differential expression in normal tissues from HIPED for ZBTB7C Gene

This gene is overexpressed in Plasma (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB7C Gene

Protein tissue co-expression partners for ZBTB7C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB7C Gene:


SOURCE GeneReport for Unigene cluster for ZBTB7C Gene:


mRNA Expression by UniProt/SwissProt for ZBTB7C Gene:

Tissue specificity: Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines.

Evidence on tissue expression from TISSUES for ZBTB7C Gene

  • Lung(2.2)
genes like me logo Genes that share expression patterns with ZBTB7C: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB7C Gene

Orthologs for ZBTB7C Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB7C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB7C 33 34
  • 99.46 (n)
(Bos Taurus)
Mammalia ZBTB7C 33 34
  • 93.15 (n)
(Canis familiaris)
Mammalia ZBTB7C 33 34
  • 91.48 (n)
-- 34
  • 86 (a)
(Mus musculus)
Mammalia Zbtb7c 33 16 34
  • 89.82 (n)
(Rattus norvegicus)
Mammalia Zbtb7c 33
  • 89.45 (n)
(Monodelphis domestica)
Mammalia ZBTB7C 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB7C 34
  • 83 (a)
(Gallus gallus)
Aves ZBTB7C 33 34
  • 77.74 (n)
(Anolis carolinensis)
Reptilia ZBTB7C 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb7c 33
  • 71.57 (n)
(Danio rerio)
Actinopterygii LOC100537080 33
  • 63.09 (n)
FP085391.3 34
  • 53 (a)
Species where no ortholog for ZBTB7C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB7C Gene

Gene Tree for ZBTB7C (if available)
Gene Tree for ZBTB7C (if available)

Paralogs for ZBTB7C Gene

Variants for ZBTB7C Gene

Sequence variations from dbSNP and Humsavar for ZBTB7C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000011 -- 48,328,680(+) TGGAA(C/T)GCCTA intron-variant
rs1000011950 -- 48,241,047(+) AGTAG(A/C)TATTC intron-variant
rs1000012436 -- 48,370,657(+) TAATG(-/A)AAAAA intron-variant
rs1000027935 -- 48,117,598(+) TAAGG(C/G/T)TTCAG intron-variant
rs1000040228 -- 48,041,967(+) CTTAT(A/C)ATTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB7C Gene

Variant ID Type Subtype PubMed ID
nsv476135 CNV novel sequence insertion 20440878
nsv2289 CNV insertion 18451855
nsv1066479 CNV gain 25217958
esv274948 CNV loss 21479260
esv2313973 CNV deletion 18987734
esv1002707 CNV deletion 20482838

Variation tolerance for ZBTB7C Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB7C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB7C Gene

Disorders for ZBTB7C Gene

Relevant External Links for ZBTB7C

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZBTB7C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB7C Gene

Publications for ZBTB7C Gene

  1. APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity. (PMID: 9427755) Reuter S … Schwarz E (The EMBO journal 1998) 3 4 60
  2. Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription. (PMID: 27646874) Jeon BN … Hur MW (Biochimica et biophysica acta 2016) 3 60
  3. Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as Susceptibility Genes to Ischemic Injury. (PMID: 26542693) Du R … Weiss ST (Stroke 2015) 3 60
  4. Genome-wide association study in Han Chinese identifies three novel loci for human height. (PMID: 23456168) Hao Y … Gu D (Human genetics 2013) 3 60
  5. The proto-oncoprotein KR-POK represses transcriptional activation of CDKN1A by MIZ-1 through competitive binding. (PMID: 21804610) Lee KM … Hur MW (Oncogene 2012) 3 60

Products for ZBTB7C Gene

Sources for ZBTB7C Gene

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