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ZBTB7C Gene

protein-coding   GIFtS: 43

GC18M043811
zinc finger and BTB domain containing 7C
(Previous name: zinc finger and BTB domain containing 36 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZBTB36)
Services    

Aliases &
Descriptions
for ZBTB7C

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
APM-1 2, 3
APM1 2, 3
B230208J24Rik 2
FLJ37907 2
ZBTB36 2, 3
ZNF857C 1, 2
Descriptions
Affected by papillomavirus DNA integration in ME180 cells
protein 1 3
BTB/POZ-zinc finger protein-like 2
Zinc finger and BTB domain-containing protein 36 3
Zinc finger and BTB domain-containing protein 7C 2
zinc finger and BTB domain containing 36 1, 2
zinc finger and BTB domain containing 7C 2
External Ids
HGNC: 317001
Entrez Gene: 2015012
UniProtKB: A1YPR03
Ensembl: ENSG000001848287
Search outside databases for aliases for ZBTB7C gene

Previous GC identifers: GC00U921557 GC18U900235

Summaries
for ZBTB7C

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT7C_HUMAN, A1YPR0
Function: May be a tumor suppressor gene

Genomic Location
for ZBTB7C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB7C gene  

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

ZBTB7C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M043811:     (about GC identifiers)

Start:
 43,807,731 bp from pter
End:
 43,821,492 bp from pter
Size:
 13,762 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000018.8  NT_010966.13  

Proteins
for ZBTB7C

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ZBT7C_HUMAN, A1YPR0 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 7C  
Size: 619 amino acids; 69017 Da
Secondary accessions: O73453

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_001034449.1  

    ENSEMBL proteins: 
    ENSP00000328732 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZBTB7C)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    About this table

    Antibodies for ZBTB7C: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZBTB7C
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZBTB7C), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ZBTB7C

    Assays for ZBTB7C: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ZBTB7C

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro domains/families (see all 6 ):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ


       GeneDecks  ZBTB7C for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry A1YPR0

    ProtoNet protein and cluster: A1YPR0

    UniProtKB/Swiss-Prot: ZBT7C_HUMAN, A1YPR0
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 4 C2H2-type zinc fingers

    Gene Function
    for ZBTB7C

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ZBTB7C)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_113971

                  Applied Biosystems Silencer® siRNAs for ZBTB7C

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB7C  
                         Sigma-Aldrich shRNA for ZBTB7C  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001039360
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001039360
                                     untagged cDNA clone in CMV expression vector: NM_001039360 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001039360

    UniProtKB/Swiss-Prot: ZBT7C_HUMAN, A1YPR0
    Function: May be a tumor suppressor gene

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding IEA--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for ZBTB7C

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045786 negative regulation of cell cycle IEA--
    About this table

    Drugs & Compounds
    for ZBTB7C

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB7C

    Transcripts
    for ZBTB7C

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ZBTB7C)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_113971

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB7C  
                         Sigma-Aldrich shRNA for ZBTB7C  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001039360  

    REFSEQ mRNAs for ZBTB7C gene: 

    NM_001039360.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001039360  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001039360
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001039360
                                     untagged cDNA clone in CMV expression vector: NM_001039360 

    Additional cDNA sequence: 

    AK095226.1 AK296709.1 AM988836.1 AM988837.1 AM988838.1 AM988839.1 AM989327.1 AM989328.1 
    AM989329.1 AM989330.1 AM989331.1 AM989332.1 AM991276.1 AM991277.1 AM991278.1 AM991279.1 
    AM991280.1 AM991281.1 AM991282.1 AM991283.1 AM991284.1 AM991285.1 AM991959.1 AM991960.1 
    AM991961.1 AM991962.1 AM991963.1 AM991964.1 AM991965.1 AM991966.1 AM991967.1 AM991968.1 
    AM991969.1 AM991970.1 AM998476.1 AM998477.1 AM998478.1 AM998479.1 AM998480.1 AM998481.1 
    AM998482.1 AM998483.1 AM998484.1 AM998485.1 AM998486.1 AM998487.1 AM998488.1 AM998489.1 
    EF120357.1 EU669438.1 

    3 DOTS entries:

    DT.108992  DT.100676670  DT.91674566 

    1 AceView cDNA sequence:

    BF594318 

    highest scoring ESTs for ZBTB7C:

    AI278995 AW298223 AW513934 BE734331 BF000285 BF056213 CD673362 CD693390 H44758 H44759 

    Unigene Cluster for ZBTB7C:

    Zinc finger and BTB domain containing 7C
    Hs.515388  [show with all ESTs]
    Unigene Representative Sequence: AM988838


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000332053  

    Expression
    for ZBTB7C

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB7C expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB7C

    1 / 2 / 3

    5 probe-sets matching ZBTB7C gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		61625_at2, 3 U95-C 1 0.75 1.00 1.00 1.00 AI278995 0.60 1.00 0.82 1

    		227782_at2, 3 U133-B 1 1.00 1.00 -- -- AI278995 0.60 1.00 0.82 1

    		217675_at2, 3 U133-A 1 0.64 1.00 -- -- BE734331 0.60 1.00 0.82 1

    		227782_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		217675_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AATAAATTGG

    SOURCE GeneReport for Unigene cluster: Hs.515388

    UniProtKB/Swiss-Prot: ZBT7C_HUMAN, A1YPR0
    Tissue specificity: Detected in normal cervical keratinocytes, and in some cervical carcinoma cell
    lines

    Orthologs
    for ZBTB7C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ZBTB7C gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ZBTB7C1   -- zinc finger and BTB domain containing 7C 92.29(n)
    96.62(a)    		 490573  XM_547695.2  XP_547695.2 
    chimpanzee
    (Pan troglodytes)    		 ZBTB7C1   -- zinc finger and BTB domain containing 7C 99.46(n)
    99.84(a)    		 455408  XM_512122.2  XP_512122.2 
    cow
    (Bos taurus)    		 ZBTB7C1   -- zinc finger and BTB domain containing 7C 93.15(n)
    97.88(a)    		 614110  XM_865473.2  XP_870566.2 
    mouse
    (Mus musculus)    		 Zbtb7c1, 5 185
    		 zinc finger and BTB domain containing 7C1, 5 89.82(n)1
    94.18(a)1    		 2072591  NM_145356.31  NP_663331.11 
     AK0455225  AK0524705  (see all 8)
    chicken
    (Gallus gallus)    		 ZBTB7C1   -- zinc finger and BTB domain containing 7C 79.9(n)
    84.31(a)    		 431576  XM_429131.2  XP_429131.2 
    About this table        Species with no ortholog for ZBTB7C

    ENSEMBL Gene Tree for ZBTB7C

    Paralogs
    for ZBTB7C

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZBTB7C gene
    ZBTB242  ZBTB7A2  ZBTB7B2  ZBTB442  

    SNPs/Variants
    for ZBTB7C

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/94 NCBI SNPs in ZBTB7C are shown (see all 94 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 48)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 18 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs72324151,2
    		F,H43822065(+) TACTCG/ATTCAT 1 -- ng314Minor allele frequency- A:0.06EU EA WA 418
    --
    rs72385611,2
    		A43807816(+) TGGCTG/TGTGGA 1 -- ut310--------
    rs72354231,2
    		H43810107(+) GGTGGT/ACAGAG 1 V/D mis1 ese34Minor allele frequency- A:0.00EU EA WA 418
    --
    rs72311511,2
    		A43809827(+) ATCTGC/TGTCTC 1 T/T syn1 ese30--------
    rs72437341,2
    		A,C,F,H43817096(+) ATTCTG/ACGTCA 1 -- int14Minor allele frequency- A:0.47EU EA WA 412
    rs46207501,2
    		A,C,F,H43813958(-) TCCAGA/CACTGG 1 -- int115Minor allele frequency- C:0.45NA EU EA WA 1396
    rs43595131,2
    		A,C,F,H43819318(+) AACCAC/GAGATA 1 -- int18Minor allele frequency- G:0.48EU EA WA NA 634
    rs80994191,2
    		A,C,F,H43812178(+) GCCAAG/ACTCAC 1 -- int111Minor allele frequency- A:0.48EU EA WA NA 962
    rs40727271,2
    		A,C,F,H43819553(-) CATTTA/GAGGAA 1 -- int1 trp34Minor allele frequency- G:0.36EU EA WA 418
    rs40740191,2
    		A,C,F,H43817673(+) GCTGGA/GTGACC 1 -- int18Minor allele frequency- G:0.29EU EA WA NA 608
    About this table

    HapMap Linkage Disequilibrium images for ZBTB7C (up to first 250kb)

    Disorders & Mutations
    for ZBTB7C

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for ZBTB7C

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ZBTB7C

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		5 PubMed articles for ZBTB7C gene:

    Search for ZBTB7C

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZBTB7C

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 201501 HGNC: 31700 AceView: LOC201501.1 Ensembl:ENSG00000184828 euGenes: HUgn201501
    ECgene: ZBTB7C H-InvDB: ZBTB7C

    Other Databases showing ZBTB7C

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing ZBTB7C

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for ZBTB7C

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ZBTB7C

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB7C:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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     Predesigned and custom siRNAs for ZBTB7C Antibodies for ZBTB7C
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     Lentivirus-delivered shRNAs for ZBTB7C Browse small molecules at Sigma-Aldrich
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