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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB7C Gene

protein-coding   GIFtS: 43
GCID: GC18M045553

Zinc Finger And BTB Domain Containing 7C

(Previous name: zinc finger and BTB domain containing 36)
(Previous symbol: ZBTB36)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 7C1 2     APM-12 3
ZBTB361 2 3     APM12 3
Zinc Finger And BTB Domain Containing 361 2     ZNF857C2 3
Affected By Papillomavirus DNA Integration In ME180 Cells Protein 12 3     B230208J24Rik2
Zinc Finger And BTB Domain-Containing Protein 362 3     Zinc Finger And BTB Domain-Containing Protein 7C2
Zinc Finger Protein 857C2 3     

External Ids:    HGNC: 317001   Entrez Gene: 2015012   Ensembl: ENSG000001848287   UniProtKB: A1YPR03   

Export aliases for ZBTB7C gene to outside databases

Previous GC identifers: GC00U921557 GC18U900235 GC18M043811 GC18M042403


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZBTB7C Gene: 
ZBTB7C (zinc finger and BTB domain containing 7C) is a protein-coding gene. Diseases associated with ZBTB7C include cervicitis. GO annotations related to this gene include zinc ion binding and nucleic acid binding. An important paralog of this gene is ZBTB18.

UniProtKB/Swiss-Prot: ZBT7C_HUMAN, A1YPR0
Function: May be a tumor suppressor gene




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB7C gene promoter:
         AREB6   AML1a   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZBTB7C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB7C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

ZBTB7C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB7C gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M045553:  view genomic region     (about GC identifiers)

Start:
45,553,044 bp from pter      End:
45,937,123 bp from pter
Size:
384,080 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZBT7C_HUMAN, A1YPR0 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 7C  
Size: 619 amino acids; 69017 Da
Secondary accessions: O73453

Explore the universe of human proteins at neXtProt for ZBTB7C: NX_A1YPR0

Explore proteomics data for ZBTB7C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A1YPR0

  • ZBTB7C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBTB7C Protein Expression
    REFSEQ proteins: NP_001034449.1  
    ENSEMBL proteins: 
     ENSP00000439781   ENSP00000468782   ENSP00000468254   ENSP00000467877   ENSP00000467323  
     ENSP00000464724   ENSP00000468659   ENSP00000466006   ENSP00000467147   ENSP00000468087  
     ENSP00000468019   ENSP00000465265   ENSP00000468306   ENSP00000465760   ENSP00000468502  
     ENSP00000468537   ENSP00000465835   ENSP00000466944   ENSP00000466088   ENSP00000467758  
     ENSP00000465160   ENSP00000468814   ENSP00000467456   ENSP00000465832   ENSP00000468752  
     ENSP00000465494   ENSP00000467338   ENSP00000468152   ENSP00000328732  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry A1YPR0

    ProtoNet protein and cluster: A1YPR0

    UniProtKB/Swiss-Prot: ZBT7C_HUMAN, A1YPR0
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 4 C2H2-type zinc fingers


    ZBTB7C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT7C_HUMAN, A1YPR0
    Function: May be a tumor suppressor gene

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZBTB7C for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zbtb7c):
     cellular 

    ZBTB7C for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBTB7C 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB7C

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/554 Interacting proteins for ZBTB7C (A1YPR02 ENSP000003287324) via UniProtKB, MINT, STRING, and/or I2D (see all 554)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTBP607092MINT-7947479
    ACTL6AO960192MINT-7947479
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB7C (ZBT7C)

    Search CenterWatch for drugs/clinical trials and news about ZBTB7C / ZBT7C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZBTB7C gene: 
    NM_001039360.2  

    Unigene Cluster for ZBTB7C:

    Zinc finger and BTB domain containing 7C
    Hs.515388  [show with all ESTs]
    Unigene Representative Sequence: AM988838
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000535628(uc002ldb.3 uc010dnu.3 uc010dnv.3 uc010dnw.3 uc010dnx.1 uc010dny.1 uc010dnz.1 uc010dol.1 uc010doa.1 uc010dob.1 uc010doc.1 uc010dod.1 uc010doe.1 uc010dof.1 uc010dog.1 uc010doh.1 uc010doi.1 uc010doj.1 uc010dok.1 uc010dom.1 uc010don.1 uc010dop.1 uc010doq.1 uc010dor.1 uc010dos.1 uc010dot.1 uc010doo.1 uc010dou.1)
    ENST00000588982 ENST00000586438 ENST00000590800 ENST00000590437 ENST00000585404
    ENST00000589619 ENST00000586743 ENST00000589077 ENST00000592656 ENST00000589194
    ENST00000591279 ENST00000590855 ENST00000587107 ENST00000588970 ENST00000586525
    ENST00000592387 ENST00000586047
    miRNA
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    hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-3653 hsa-miR-124 hsa-miR-204 hsa-miR-548x hsa-miR-1243 hsa-miR-326
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AK095226.1 AK296709.1 AM988836.1 AM988837.1 AM988838.1 AM988839.1 EF120357.1 

    1 DOTS entry:

    DT.108992 

    1 AceView cDNA sequence:

    BF594318 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB7C expression in normal human tissues (normalized intensities)      ZBTB7C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAATTGG
    ZBTB7C Expression
    About this image


    ZBTB7C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Brain (Nervous System)
             Medulla Oblongata

    See ZBTB7C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB7C

    SOURCE GeneReport for Unigene cluster: Hs.515388

    UniProtKB/Swiss-Prot: ZBT7C_HUMAN, A1YPR0
    Tissue specificity: Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB7C gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb7c1 , 5 zinc finger and BTB domain containing 7C1, 5 89.82(n)1
    94.18(a)1
      18 (51.10 cM)5
    2072591  NM_145356.31  NP_663331.11 
     758201785 
    chicken
    (Gallus gallus)
    Aves ZBTB7C1 zinc finger and BTB domain containing 7C 78.15(n)
    80.5(a)
      431576  XM_429131.3  XP_429131.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB7C6
    Uncharacterized protein
    74(a)
    1 ↔ 1
    2(831722-1116933)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005370801 zinc finger and BTB domain-containing protein 7C-like 62.44(n)
    60.21(a)
      100537080  XM_003200810.1  XP_003200858.1 


    ENSEMBL Gene Tree for ZBTB7C (if available)
    TreeFam Gene Tree for ZBTB7C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB7C gene
    ZBTB182  ZBTB212  ZBTB32  ZBTB142  ZBTB7B2  ENSG000002545532  ZBTB462  ZBTB8B2  
    ZBTB102  ZBTB8A2  ZBTB7A2  ZBTB52  ZBTB442  ZBTB492  ZBTB242  ZBTB422  
    MYNN2  
    18/41 SIMAP similar genes for ZBTB7C using alignment to 7 protein entries:     ZBT7C_HUMAN (see all proteins) (see all similar genes):
    KLHL32    BACH1    BACH2    ZBTB17    HIC1    ZBTB1
    KLHL14    KLHL36    KLHL3    ZBTB21    KLHL2    ZBTB49
    ZBTB44    ZNF295    ZNF131    ZBTB16    ZBTB3    ZBTB38

    ZBTB7C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2268 SNPs in ZBTB7C are shown (see all 2268)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903170661,2
    --45553378(+) AACTTC/TGTTGA 1 -- int10--------
    rs1509302381,2
    --45553421(+) AAGAGA/TTATAA 1 -- int10--------
    rs2005825671,2
    C--45553478(+) AACATA/CAAAAA 1 -- int10--------
    rs114311681,2
    C--45553493(+) AAAAA-/A/AA  
            
    TTGAA
    1 -- int10--------
    rs734459821,2
    C,F--45553529(+) CCCCCC/GACAAC 1 -- int15Minor allele frequency- G:0.34WA NA EA 362
    rs1406432651,2
    --45553562(+) CATACA/GGTACT 1 -- int10--------
    rs1819621621,2
    --45553568(+) GTACTC/TAACAT 1 -- int10--------
    rs1874189871,2
    --45553645(+) CATCTA/GAAAAA 1 -- ut310--------
    rs1444907991,2
    C--45553707(+) CACCAC/TTGGAT 1 -- ut310--------
    rs794032031,2
    C--45553748(+) TTTTTC/TCTCTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZBTB7C (45553044 - 45803044 bp, first 250kb of ZBTB7C)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZBTB7C:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1002707CNV Deletion20482838
    esv2313973CNV Deletion18987734
    nsv2289CNV Insertion18451855
    esv274948CNV Loss21479260
    nsv909616CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZBTB7C:    About MalaCards
    cervicitis    


    ZBTB7C for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZBTB7C

    Export disorders for ZBTB7C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB7C gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZBTB7C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity. (PubMed id 9427755)1, 2 Reuter S.... Schwarz E. (1998)
    2. Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter. (PubMed id 22331133)1 Jeon B.N....Hur M.W. (2012)
    3. KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A. (PubMed id 22253232)1 Jeon B.N....Hur M.W. (2012)
    4. Adrenomedullin and adrenomedullin binding protein-1 protect endothelium-dependent vascular relaxation in sepsis. (PubMed id 17932560)1 Zhou M....Wang P. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    6. Characterization of a novel human papillomavirus DNA in the cervical carcinoma cell line ME180. (PubMed id 1716694)1 Reuter S....Schwarz E. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 201501 HGNC: 31700 AceView: LOC201501.1 Ensembl:ENSG00000184828 euGenes: HUgn201501
    ECgene: ZBTB7C H-InvDB: ZBTB7C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB7C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZBTB7C gene:
    Search GeneIP for patents involving ZBTB7C

    GeneCards and IP:
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