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Aliases for ZBTB7C Gene

Aliases for ZBTB7C Gene

  • Zinc Finger And BTB Domain Containing 7C 2 3
  • Affected By Papillomavirus DNA Integration In ME180 Cells Protein 1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 36 3 4
  • Zinc Finger And BTB Domain Containing 36 2 3
  • Zinc Finger Protein 857C 3 4
  • ZNF857C 3 4
  • ZBTB36 3 4
  • APM-1 3 4
  • APM1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 7C 3
  • Zinc Finger And BTB Domain-Containing 7C 3
  • B230208J24Rik 3

External Ids for ZBTB7C Gene

Previous HGNC Symbols for ZBTB7C Gene

  • ZBTB36

Previous GeneCards Identifiers for ZBTB7C Gene

  • GC00U921557
  • GC18U900235
  • GC18M043811
  • GC18M045553
  • GC18M042403

Summaries for ZBTB7C Gene

GeneCards Summary for ZBTB7C Gene

ZBTB7C (Zinc Finger And BTB Domain Containing 7C) is a Protein Coding gene. Among its related pathways are AMPK Enzyme Complex Pathway. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBTB7B.

UniProtKB/Swiss-Prot for ZBTB7C Gene

  • May be a tumor suppressor gene.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB7C Gene

Genomics for ZBTB7C Gene

Regulatory Elements for ZBTB7C Gene

Transcription factor binding sites by QIAGEN in the ZBTB7C gene promoter:

Genomic Location for ZBTB7C Gene

48,026,672 bp from pter
48,410,752 bp from pter
384,081 bases
Minus strand

Genomic View for ZBTB7C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB7C Gene

Proteins for ZBTB7C Gene

  • Protein details for ZBTB7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 7C
    Protein Accession:
    Secondary Accessions:
    • O73453

    Protein attributes for ZBTB7C Gene

    619 amino acids
    Molecular mass:
    69017 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB7C Gene

Proteomics data for ZBTB7C Gene at MOPED

Post-translational modifications for ZBTB7C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZBTB7C Gene

Domains for ZBTB7C Gene

Gene Families for ZBTB7C Gene

  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Graphical View of Domain Structure for InterPro Entry



  • A1YPR0
  • Contains 1 BTB (POZ) domain.
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB7C: view

Function for ZBTB7C Gene

Molecular function for ZBTB7C Gene

UniProtKB/Swiss-Prot Function:
May be a tumor suppressor gene.

Gene Ontology (GO) - Molecular Function for ZBTB7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB7C: view

Phenotypes for ZBTB7C Gene

MGI mutant phenotypes for ZBTB7C:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ZBTB7C: view

Animal Model Products

miRNA for ZBTB7C Gene

miRTarBase miRNAs that target ZBTB7C

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB7C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB7C Gene

Localization for ZBTB7C Gene

Subcellular locations from

Jensen Localization Image for ZBTB7C Gene COMPARTMENTS Subcellular localization image for ZBTB7C gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZBTB7C Gene

Pathways for ZBTB7C Gene

SuperPathways for ZBTB7C Gene

Superpath Contained pathways
1 AMPK Enzyme Complex Pathway
genes like me logo Genes that share pathways with ZBTB7C: view

Pathways by source for ZBTB7C Gene

1 Qiagen pathway for ZBTB7C Gene

Interacting Proteins for ZBTB7C Gene

Selected Interacting proteins: A1YPR0-ZBT7C_HUMAN for ZBTB7C Gene via MINT

Gene Ontology (GO) - Biological Process for ZBTB7C Gene


Transcripts for ZBTB7C Gene

Unigene Clusters for ZBTB7C Gene

Zinc finger and BTB domain containing 7C:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB7C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7C Gene

No ASD Table

Relevant External Links for ZBTB7C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB7C Gene

mRNA expression in normal human tissues for ZBTB7C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB7C Gene

This gene is overexpressed in Esophagus - Mucosa (7.5) and Skin - Sun Exposed (Lower leg) (4.2).

Protein differential expression in normal tissues for ZBTB7C Gene

This gene is overexpressed in Plasma (68.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZBTB7C Gene

SOURCE GeneReport for Unigene cluster for ZBTB7C Gene Hs.515388

mRNA Expression by UniProt/SwissProt for ZBTB7C Gene

Tissue specificity: Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines.
genes like me logo Genes that share expressions with ZBTB7C: view

Expression partners for ZBTB7C Gene

In Situ Assay Products

Orthologs for ZBTB7C Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB7C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZBTB7C 35
  • 93.15 (n)
  • 97.88 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ZBTB7C 35
  • 91.48 (n)
  • 95.47 (a)
-- 36
  • 86 (a)
  • 95 (a)
(Mus musculus)
Mammalia Zbtb7c 35
  • 89.82 (n)
  • 94.18 (a)
Zbtb7c 16
Zbtb7c 36
  • 94 (a)
(Pan troglodytes)
Mammalia ZBTB7C 35
  • 99.46 (n)
  • 99.84 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Zbtb7c 35
  • 89.45 (n)
  • 94.51 (a)
(Monodelphis domestica)
Mammalia ZBTB7C 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB7C 36
  • 83 (a)
(Gallus gallus)
Aves ZBTB7C 35
  • 77.74 (n)
  • 79.53 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia ZBTB7C 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb7c 35
  • 71.57 (n)
  • 70.57 (a)
(Danio rerio)
Actinopterygii LOC100537080 35
  • 63.09 (n)
  • 59.86 (a)
FP085391.3 36
  • 53 (a)
Species with no ortholog for ZBTB7C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB7C Gene

Gene Tree for ZBTB7C (if available)
Gene Tree for ZBTB7C (if available)

Paralogs for ZBTB7C Gene

Paralogs for ZBTB7C Gene

genes like me logo Genes that share paralogs with ZBTB7C: view

Variants for ZBTB7C Gene

Sequence variations from dbSNP and Humsavar for ZBTB7C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs732130 -- 48,363,182(+) TGTTG(A/G)GGTTT intron-variant
rs745010 -- 48,363,074(+) gaatg(C/T)cagaa intron-variant
rs745611 -- 48,382,669(-) TGTGA(A/C)TTTTG intron-variant
rs752724 -- 48,359,963(+) GTTGT(A/T)CTGGT intron-variant
rs752725 -- 48,359,582(+) GCATA(A/C/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB7C Gene

Variant ID Type Subtype PubMed ID
nsv909616 CNV Gain 21882294
esv274948 CNV Loss 21479260
nsv2289 CNV Insertion 18451855
esv1002707 CNV Deletion 20482838
esv2313973 CNV Deletion 18987734

Relevant External Links for ZBTB7C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB7C Gene

Disorders for ZBTB7C Gene

Relevant External Links for ZBTB7C

Genetic Association Database (GAD)

No disorders were found for ZBTB7C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZBTB7C Gene

Publications for ZBTB7C Gene

  1. APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity. (PMID: 9427755) Reuter S. … Schwarz E. (EMBO J. 1998) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Adrenomedullin and adrenomedullin binding protein-1 protect endothelium-dependent vascular relaxation in sepsis. (PMID: 17932560) Zhou M. … Wang P. (Mol. Med. 2007) 3
  4. KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A. (PMID: 22253232) Jeon B.N. … Hur M.W. (Cancer Res. 2012) 3
  5. Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter. (PMID: 22331133) Jeon B.N. … Hur M.W. (J. Lipid Res. 2012) 3

Products for ZBTB7C Gene

Sources for ZBTB7C Gene

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