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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB7B Gene

protein-coding   GIFtS: 55
GCID: GC01P154975

zinc finger and BTB domain containing 7B

(Previous name: zinc finger protein 67 homolog (mouse) )
(Previous symbol: ZFP67)
 Explore 3 diseases affiliated with
ZBTB7B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZBTB7B    

Aliases
for ZBTB7B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger And BTB Domain Containing 7B1 2     C-Krox1
ZBTB151 2 3     Zinc Finger Protein 67 Homolog (Mouse)1
ZFP671 2 3     THPOK2
ZNF857B1 2 3     ZFP-672
HcKrox1     C-KROX1
Krueppel-Related Zinc Finger Protein CKrox2 3     HcKROX1
Zinc Finger Protein 67 Homolog2 3     Zinc Finger And BTB Domain Containing 152
Zinc Finger Protein 857B2 3     Zinc Finger And BTB Domain-Containing Protein 7B2
Zinc Finger Protein Th-POK2 3     Zfp-673
T-Helper-Inducing POZ/Krueppel-Like Factor2 3     Zinc Finger And BTB Domain-Containing Protein 153

External Ids:    HGNC: 186681   Entrez Gene: 510432   Ensembl: ENSG000001606857   OMIM: 6076465   UniProtKB: O151563   

Export aliases for ZBTB7B gene to outside databases

Previous GC identifers: GC01P151790 GC01P153242 GC01P126337


Summaries
for ZBTB7B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZBTB7B:
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of
immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8
commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156
Function: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors.
Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of
immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely
with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules,
respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of
fibronectin and possibly other extracellular matrix genes (By similarity)

Gene Wiki entry for ZBTB7B


Genomic Views
for ZBTB7B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB7B gene promoter:
         CREB   AML1a   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZBTB7B promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB7B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

ZBTB7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB7B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154975:  view genomic region     (about GC identifiers)

Start:
 154,975,112 bp from pter      End:
 154,990,999 bp from pter
Size:
 15,888 bases      Orientation:
 plus strand

Proteins
for ZBTB7B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 7B  
Size: 539 amino acids; 58027 Da
Subcellular location: Nucleus
Sequence caution: Sequence=CAH18158.1; Type=Erroneous initiation;
Secondary accessions: B4E3K5 D3DV83 J3KQQ3 Q68DR2 Q96EP2
Alternative splicing: 2 isoforms:  O15156-1   O15156-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZBTB7B: NX_O15156

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15156

    • ZBTB7B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239335.1  NP_001243384.1  

    ENSEMBL proteins: 
     ENSP00000357411   ENSP00000292176   ENSP00000406286   ENSP00000438647  

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    Novus Biologicals ZBTB7B Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZBTB7B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--


    ZBTB7B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZBTB7B

    Protein Domains /
    Families
    for ZBTB7B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZBTB7B for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry O15156

    ProtoNet protein and cluster: O15156

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 4 C2H2-type zinc fingers


    Function
    for ZBTB7B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156
    Function: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors.
    Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of
    immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely
    with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules,
    respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of
    fibronectin and possibly other extracellular matrix genes (By similarity)

    miRNA
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    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB7B (see all 79):
    hsa-miR-323-3p hsa-miR-3194-5p hsa-miR-3938 hsa-miR-1321 hsa-miR-3607-3p hsa-miR-1914* hsa-miR-3622b-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: ZBTB7B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZBTB7B for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for ZBTB7B: Zbtb7btm1Itan Zbtb7btm1.2Litt Zbtb7btm1.1Rbo
         6 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Zbtb7b):
     cellular  hematopoietic system  immune system  no phenotypic analysis  normal 
     reproductive system 

    ZBTB7B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ZBTB7B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/18 Interacting proteins for ZBTB7B (O151562, 3 ENSP000002921764) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPH1Q925983, ENSP000003186874I2D: score=1 STRING: ENSP00000318687
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    MYBBP1AQ9BQG03, ENSP000003709684I2D: score=1 STRING: ENSP00000370968
    PRPF8Q6P2Q93, ENSP000003043504I2D: score=1 STRING: ENSP00000304350
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS7937772
    GO:0007275multicellular organismal development IEA--
    GO:0007398ectoderm development TAS7937772
    GO:0030154cell differentiation IEA--


    ZBTB7B for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZBTB7B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB7B
    Search CenterWatch for drugs/clinical trials and news about ZBTB7B / ZBT7B 

    Transcripts
    for ZBTB7B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZBTB7B gene (2 alternative transcripts): 
    NM_001252406.2  NM_001256455.1  

    Unigene Cluster for ZBTB7B:

    Zinc finger and BTB domain containing 7B
    Hs.729279  [show with all ESTs]
    Unigene Representative Sequence: NM_001252406
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368426(uc001fgj.4 uc009wpa.3 uc001fgk.4 uc010peq.2 uc001fgl.4)
    ENST00000487542 ENST00000461530 ENST00000483226 ENST00000292176 ENST00000417934
    ENST00000535420

    miRNA
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    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB7B (see all 79):
    hsa-miR-323-3p hsa-miR-3194-5p hsa-miR-3938 hsa-miR-1321 hsa-miR-3607-3p hsa-miR-1914* hsa-miR-3622b-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: ZBTB7B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBTB7B (see all 7)
    OriGene shRNA RFP: ZBTB7B
    OriGene siRNA: ZBTB7B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB7B
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF007833.1 AK127884.1 AK291619.1 AK304762.1 BC012070.1 BC128176.1 CR749303.1 NR_045515.1 
    NR_046206.1 NR_049765.1 

    11 DOTS entries:

    DT.106370  DT.91828569  DT.95167263  DT.121414061  DT.92030781  DT.100813869  DT.91700072  DT.121413799 
    DT.121413978  DT.75189212  DT.95368738 

    24/103 AceView cDNA sequences (see all 103):

    AL541093 CA426792 AL045086 BE264814 BF510901 CB053797 BM801567 BX114870 
    AI640907 AA302854 BG742178 BM710078 AW663133 AA985620 BC012070 BM717964 
    AW673776 AF007833 BM853822 BG775179 BI766940 AW674099 CK820290 BM705139 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7B (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b
    SP1:              -           -     -     -           -                                                   
    SP2:                          -           -     -     -                                                   
    SP3:                          -     -     -           -                                                   
    SP4:                          -     -     -     -     -                                                   
    SP5:                          -                                                                           


    ECgene alternative splicing isoforms for ZBTB7B

    Expression
    for ZBTB7B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB7B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCATTTGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZBTB7B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZBTB7B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB7B

    SOURCE GeneReport for Unigene cluster: Hs.729279
        SABiosciences Expression via Pathway-Focused PCR Array including ZBTB7B: 
              T Helper Cell Differentiation in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for ZBTB7B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB7B gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia ZBTB7B6
    		 --
    		 46(a)
    		 1 ↔ 1
    		 AAWZ02038334(1944-6667)
    African clawed frog
    (Xenopus laevis)    		 Amphibia cpg-A2 POZ/zinc finger protein, champignon 79.95(n)    AB029074.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc634892 hypothetical protein MGC63489 75.29(n)   393602  BC057297.1 


    ENSEMBL Gene Tree for ZBTB7B (if available)
    TreeFam Gene Tree for ZBTB7B (if available) 

    Paralogs
    for ZBTB7B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB7B gene
    ZBTB7C2  ZBTB7A2  
    2 SIMAP similar genes for ZBTB7B using alignment to 1 protein entry:     ZBT7B_HUMAN:
    ZBTB7C    ZBTB7A

    ZBTB7B for paralogs           About GeneDecksing



    Genomic Variants
    for ZBTB7B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/220 NCBI SNPs in ZBTB7B are shown (see all 220)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs127299861,2
    		C,H--154973218(+) CCGCCT/GAGCCC 5 -- us2k13Minor allele frequency- G:0.00EA NS 298
    rs1843422571,2
    		--154973242(+) TCACCA/CGGCCT 5 -- us2k10--------
    rs1130568781,2
    		C,--154973294(+) CTGGACCCCAC/-
                ACGGC     		5 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs1887802201,2
    		--154973392(+) GACGAC/TAGGAA 5 -- us2k10--------
    rs1475599951,2
    		--154973608(+) AGAGG-/GAGAGAG 5 -- us2k10--------
    rs1158838101,2
    		--154973707(+) CGCCGA/CCCATT 5 -- us2k10--------
    rs1812415531,2
    		--154973718(+) GTGGTC/TCAACA 5 -- us2k10--------
    rs1440221381,2
    		--154973984(+) TTATCC/TCGGTC 5 -- us2k10--------
    rs1838689451,2
    		--154974586(+) CACTGA/CCCCCT 5 -- us2k10--------
    rs778851141,2
    		C,F,--154974619(+) GGCCAG/ACCCCT 5 -- us2k11Minor allele frequency- A:0.06NA 120

    HapMap Linkage Disequilibrium report for ZBTB7B (154975112 - 154990999 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZBTB7B
         1 CNV: 84592

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    Disorders / Diseases
    for ZBTB7B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZBTB7B for disorders           About GeneDecksing

    OMIM gene information: 607646    OMIM disorders: --

    3 diseases for ZBTB7B:    About MalaCards
    systemic scleroderma    scleroderma    thymoma

    Human Genome Epidemiology (HuGE) Navigator: ZBTB7B (2 documents)

    Export disorders for ZBTB7B gene to outside databases

    Publications
    for ZBTB7B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB7B gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with ZBTB7B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression. (PubMed id 9370309)1, 2, 3 Widom R.L.... Korn J.H. (1997)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. (PubMed id 7937772)1, 3 Galera P....Karsenty G. (1994)
    5. Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. (PubMed id 17698844)1, 9 Kypriotou M....Galera P. (2007)
    6. CD4-CD8 lineage differentiation: Thpok-ing into the n ucleus. (PubMed id 19696430)1, 9 Wang L. and Bosselut R. (2009)
    7. Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1. (PubMed id 18298657)1, 9 Renard E....GalAcra P. (2008)
    8. Epigenetic silencing of CD8 genes by ThPOK-mediated de acetylation during CD4 T cell differentiation. (PubMed id 22730529)1 Rui J....Liu X. (2012)
    9. Genetic and epigenetic mechanisms collaborate to cont rol SERPINA3 expression and its association with placental diseases. (PubMed id 22246292)1 Chelbi S.T....Vaiman D. (2012)
    10. The p65 subunit of NF-I_B inhibits COL1A1 gene transcr iption in human dermal and scleroderma fibroblasts through its recruitment on p romoter by protein interaction with transcriptional activators (c-Krox, Sp1, an d Sp3). (PubMed id 22139845)1 Beauchef G....Galera P. (2012)

    External Searches for ZBTB7B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZBTB7B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51043 HGNC: 18668 AceView: ZFP67 Ensembl:ENSG00000160685 euGenes: HUgn51043
    ECgene: ZBTB7B H-InvDB: ZBTB7B

    Other Databases showing ZBTB7B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZBTB7B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB7B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZBTB7B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZBTB7B gene:
    Search GeneIP for patents involving ZBTB7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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