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ZBTB7B Gene

protein-coding   GIFtS: 54

GC01P153242
zinc finger and BTB domain containing 7B
(Previous name: zinc finger protein 67 homolog (mouse) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZFP67)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp686G01254 2
OTTHUMP00000035544 2
OTTHUMP00000035545 2
THPOK 2
ZBTB15 1, 2, 3
ZFP67 2, 3
ZNF857B 1, 2
Zfp-67 3
c-Krox 1, 2
hcKrox 1, 2, 3
Descriptions
Krueppel-related zinc finger protein cKrox 3
T-helper-inducing POZ/Krueppel-like factor 3
Zinc finger and BTB domain-containing protein 15 3
Zinc finger protein 67 homolog 2, 3
Zinc finger protein Th-POK 3
kruppel-related zinc finger protein hcKrox 2
zinc finger and BTB domain containing 15 2
zinc finger and BTB domain containing 7B 2
zinc finger protein 67 homolog (mouse) 1
External Ids
HGNC: 186681
Entrez Gene: 510432
UniProtKB: O151563
Ensembl: ENSG000001606857
Search outside databases for aliases for ZBTB7B gene

Previous GC identifer: GC01P151790

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ZBTB7B:
ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor
that binds to the promoter regions of type I collagen genes (e.g., COL1A1; MIM 120150) and has a
role in development.[supplied by OMIM]

UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156
Function: Transcription regulator that acts as a key regulator of lineage commitment of immature
T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence
causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4
helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity
for major histocompatibility complex class II or class I molecules, respectively. Transcriptional
repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin
and possibly other extracellular matrix genes (By similarity)

Gene Wiki entry for ZBTB7B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB7B gene  

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

ZBTB7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153242:     (about GC identifiers)

Start:
153,241,736 bp from pter
End:
153,257,623 bp from pter
Size:
15,888 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 7B  
Size: 539 amino acids; 58027 Da
Subcellular location: Nucleus
Secondary accessions: Q68DR2 Q96EP2

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_056956.2  

    ENSEMBL proteins: 
    ENSP00000357411 ENSP00000292176 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ThPok)
    Human Recombinant Proteins from Abnova (ZBTB7B)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZBTB7B: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZBTB7B
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ThPok), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ZBTB7B)
    Novus Biologicals Antibody for ZBTB7B

    Assays for ZBTB7B: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ


       GeneDecks  ZBTB7B for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O15156

    ProtoNet protein and cluster: O15156

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 4 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB7B)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB7B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015872

                  Applied Biosystems Silencer® siRNAs for ZBTB7B

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB7B  
                         Sigma-Aldrich shRNA for ZBTB7B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ZBTB7B
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015872
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015872
                                     untagged cDNA clone in CMV expression vector: NM_015872 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_015872

    UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156
    Function: Transcription regulator that acts as a key regulator of lineage commitment of immature
    T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence
    causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4
    helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity
    for major histocompatibility complex class II or class I molecules, respectively. Transcriptional
    repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin
    and possibly other extracellular matrix genes (By similarity)

    5 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Zbtb7b):

    hematopoietic systemimmune systemno phenotypic analysisnormalreproductive system

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0003704 specific RNA polymerase II transcription factor activity TAS7937772
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/8 Interacting proteins for ZBTB7B (O151562 ENSP000003574113) via UniProtKB, MINT, and/or STRING (see all 8 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDCP1ENSP000002961293STRING (score=.972)
    CD8AENSP000002836353STRING (score=.947)
    CD4ENSP000000116533STRING (score=.945)
    FN1ENSP000003235343STRING (score=.9)
    COL2A1ENSP000003465113STRING (score=.866)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007275 multicellular organismal development IEA--
    GO:0007398 ectoderm development TAS7937772
    GO:0030154 cell differentiation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB7B

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB7B)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB7B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015872

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB7B  
                         Sigma-Aldrich shRNA for ZBTB7B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_015872  

    REFSEQ mRNAs for ZBTB7B gene: 

    NM_015872.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_015872  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015872
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015872
                                     untagged cDNA clone in CMV expression vector: NM_015872 

    Additional cDNA sequence: 

    AF007833.1 AK127884.1 AK291619.1 AK304762.1 BC012070.1 BC128176.1 CR749303.1 

    12 DOTS entries:

    DT.106370  DT.91828569  DT.95167263  DT.92030781  DT.121414061  DT.100813869  DT.121413799  DT.121413978 
    DT.75189212  DT.95368738  DT.40132993  DT.91700072 

    24/103 AceView cDNA sequences (see all 103 ):

    BM801567 AA302854 AW663133 BC012070 BF510901 CB053797 BE264814 AA985620 
    AL541093 BG742178 BM717964 AI640907 BM710078 CA426792 BX114870 AL045086 
    AK127884 C04237 CD516754 NM_015872 BQ879134 AA337193 BG336966 CD245481 

    highest scoring ESTs for ZBTB7B:

    AA676723 AF007833 AA302853 AA302854 AA337193 AA918560 AI475643 AK127884 AL568730 AW673776 

    Unigene Cluster for ZBTB7B:

    Zinc finger and BTB domain containing 7B
    Hs.700874  [show with all ESTs]
    Unigene Representative Sequence: NM_015872


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7B (see all 9 )

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b
    SP1:              -           -     -     -           -                                                   
    SP2:                          -           -     -     -                                                   
    SP3:                          -     -     -           -                                                   
    SP4:                          -     -     -     -     -                                                   
    SP5:                          -                                                                           

    About this scheme

    ECgene alternative splicing isoforms for ZBTB7B

    2 Ensembl transcripts including schematic representations:
    ENST00000368426  ENST00000292176  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB7B expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB7B

    1 / 2 / 3

    7 probe-sets matching ZBTB7B gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    90759_at2, 3 U95-E 1 1.00 1.00 0.80 1.77 AA676723 1.00 1.00 1.00 1

    33592_at2, 3 U95-A 1 1.00 1.00 0.68 0.33 AF007833 1.00 1.00 1.00 1

    72054_f_at2, 3 U95-E 1 1.00 1.00 0.50 0.94 AL045086 0.60 1.00 0.82 1

    205853_at2, 3 U133-A 1 1.00 1.00 -- -- NM_015872 0.60 1.00 0.82 1

    235145_at2, 3 U133-B 1 0.91 1.00 -- -- BE778059 0.80 1.00 0.91 1

    205853_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    235145_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCCATTTGCA

    SOURCE GeneReport for Unigene cluster: Hs.700874
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZBTB7B gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZBTB7B1   -- zinc finger and BTB domain containing 7B 88.93(n)
    94.99(a)
    490437  XM_547559.2  XP_547559.2 
    chimpanzee
    (Pan troglodytes)
    ZBTB7B1   -- zinc finger and BTB domain containing 7B 99.74(n)
    100(a)
    457353  XM_513845.2  XP_513845.1 
    cow
    (Bos taurus)
    ZBTB7B1   -- zinc finger and BTB domain containing 7B 89.16(n)
    94.95(a)
    509019  XM_585895.3  XP_585895.3 
    rat
    (Rattus norvegicus)
    Zbtb7b1   -- zinc finger and BTB domain containing 7B 87.51(n)
    92.21(a)
    295248  XM_215633.4  XP_215633.2 
    mouse
    (Mus musculus)
    Zbtb7b1, 5 3 (45.00 cM)5
    zinc finger and BTB domain containing 7B1, 5 87.82(n)1
    91.84(a)1
    227241  NM_009565.41  NP_033591.21 
     AI4280105  AK1499765  (see all 13)
    About this table        Species with no ortholog for ZBTB7B

    ENSEMBL Gene Tree for ZBTB7B
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZBTB7B gene
    ZBTB242  ZBTB7C2  ZBTB7A2  ZBTB442  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/44 NCBI SNPs in ZBTB7B are shown (see all 44 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 18)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs66730811,2
    A,C,F,H153256219(+) CCCTTC/TCGAGA 1 -- ut31 trp34Minor allele frequency- T:0.31EU EA WA 416
    rs22421941,2
    C,F153256921(-) CACAGC/GTCCGC 1 -- ut31 ese31Minor allele frequency- G:0.07EA 1486
    --
    rs127299861,2
    H153239842(+) CCGCCT/GAGCCC 1 -- ng513Minor allele frequency- G:0.00EA WA 298
    rs112642951,2
    A,C,F,H153254150(+) GAGATT/CCCGTG 1 I/I syn15Minor allele frequency- C:0.36NA EU EA WA 472
    rs22421951,2
    C,F153255581(-) GGTGGC/TGGGTA 1 P/P syn1 ese32Minor allele frequency- T:0.09EA NA 1570
    rs48457001,2
    A,C,F,H153248332(+) CCAGGT/CCAGGA 1 -- int14Minor allele frequency- C:0.33EU EA WA 418
    rs48454021,2
    A,C,F,H153244553(+) TGGAGG/AAGGTT 1 -- int18Minor allele frequency- A:0.04NA EU EA WA 660
    rs38202251,2
    A,C,F,H153253417(-) TTCATA/GGAGGT 1 -- int18Minor allele frequency- G:0.33EU EA WA 832
    rs112642941,2
    A,C,H153246185(+) GAAAGT/CCAGAA 1 -- int14Minor allele frequency- C:0.00EU EA WA 360
    rs18709401,2
    A,F,H153250987(+) GTCTAG/AGAGGG 1 -- int16Minor allele frequency- A:0.03NA PA EA WA 512
    About this table

    HapMap Linkage Disequilibrium images for ZBTB7B (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 607646

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/14 PubMed articles for ZBTB7B gene (see all 14 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 51043 HGNC: 18668 AceView: ZFP67 Ensembl:ENSG00000160685 euGenes: HUgn51043
    ECgene: ZBTB7B H-InvDB: ZBTB7B
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB7B:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB7B-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ZBTB7B Antibodies for ZBTB7B
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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