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Aliases for ZBTB7B Gene

Aliases for ZBTB7B Gene

  • Zinc Finger And BTB Domain Containing 7B 2 3 5
  • Krueppel-Related Zinc Finger Protein CKrox 3 4
  • T-Helper-Inducing POZ/Krueppel-Like Factor 3 4
  • Zinc Finger And BTB Domain Containing 15 2 3
  • Zinc Finger Protein 67 Homolog 3 4
  • Zinc Finger Protein Th-POK 3 4
  • Zinc Finger Protein 857B 3 4
  • ZNF857B 3 4
  • ZFP-67 3 4
  • HcKROX 3 4
  • ZBTB15 3 4
  • ZFP67 3 4
  • Zinc Finger And BTB Domain-Containing Protein 7B 3
  • Zinc Finger And BTB Domain-Containing Protein 15 4
  • Zinc Finger Protein 67 Homolog (Mouse) 2
  • C-KROX 3
  • CKROX 3
  • THPOK 3

External Ids for ZBTB7B Gene

Previous HGNC Symbols for ZBTB7B Gene

  • ZFP67

Previous GeneCards Identifiers for ZBTB7B Gene

  • GC01P151790
  • GC01P153242
  • GC01P154975
  • GC01P126337

Summaries for ZBTB7B Gene

Entrez Gene Summary for ZBTB7B Gene

  • This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ZBTB7B Gene

ZBTB7B (Zinc Finger And BTB Domain Containing 7B) is a Protein Coding gene. Among its related pathways are NF-kappaB Signaling. An important paralog of this gene is ZBTB7C.

UniProtKB/Swiss-Prot for ZBTB7B Gene

  • Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).

Gene Wiki entry for ZBTB7B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB7B Gene

Genomics for ZBTB7B Gene

Regulatory Elements for ZBTB7B Gene

Enhancers for ZBTB7B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZBTB7B on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB7B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB7B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB7B Gene

Chromosome:
1
Start:
155,002,627 bp from pter
End:
155,018,525 bp from pter
Size:
15,899 bases
Orientation:
Plus strand

Genomic View for ZBTB7B Gene

Genes around ZBTB7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB7B Gene

Proteins for ZBTB7B Gene

  • Protein details for ZBTB7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15156-ZBT7B_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 7B
    Protein Accession:
    O15156
    Secondary Accessions:
    • B4E3K5
    • D3DV83
    • J3KQQ3
    • Q68DR2
    • Q96EP2

    Protein attributes for ZBTB7B Gene

    Size:
    539 amino acids
    Molecular mass:
    58027 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH18158.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBTB7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB7B Gene

Post-translational modifications for ZBTB7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB7B Gene

No data available for DME Specific Peptides for ZBTB7B Gene

Domains & Families for ZBTB7B Gene

Gene Families for ZBTB7B Gene

Suggested Antigen Peptide Sequences for ZBTB7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15156

UniProtKB/Swiss-Prot:

ZBT7B_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB7B: view

Function for ZBTB7B Gene

Molecular function for ZBTB7B Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).

Gene Ontology (GO) - Molecular Function for ZBTB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IEA,IPI 21516116
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with ZBTB7B: view
genes like me logo Genes that share phenotypes with ZBTB7B: view

Animal Models for ZBTB7B Gene

MGI Knock Outs for ZBTB7B:

Animal Model Products

CRISPR Products

miRNA for ZBTB7B Gene

miRTarBase miRNAs that target ZBTB7B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB7B Gene

Localization for ZBTB7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB7B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB7B Gene COMPARTMENTS Subcellular localization image for ZBTB7B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZBTB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB7B: view

Pathways & Interactions for ZBTB7B Gene

SuperPathways for ZBTB7B Gene

Superpath Contained pathways
1 NF-kappaB Signaling
genes like me logo Genes that share pathways with ZBTB7B: view

Pathways by source for ZBTB7B Gene

1 Cell Signaling Technology pathway for ZBTB7B Gene

Gene Ontology (GO) - Biological Process for ZBTB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 7937772
GO:0007275 multicellular organism development IEA --
GO:0007398 ectoderm development TAS 7937772
GO:0010628 positive regulation of gene expression IEA,IBA --
genes like me logo Genes that share ontologies with ZBTB7B: view

No data available for SIGNOR curated interactions for ZBTB7B Gene

Drugs & Compounds for ZBTB7B Gene

No Compound Related Data Available

Transcripts for ZBTB7B Gene

Unigene Clusters for ZBTB7B Gene

Zinc finger and BTB domain containing 7B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - - - - -
SP7:
SP8:
SP9: - - - -

Relevant External Links for ZBTB7B Gene

GeneLoc Exon Structure for
ZBTB7B
ECgene alternative splicing isoforms for
ZBTB7B

Expression for ZBTB7B Gene

mRNA expression in normal human tissues for ZBTB7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB7B Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for ZBTB7B Gene

This gene is overexpressed in Lung (41.4) and Placenta (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB7B Gene



Protein tissue co-expression partners for ZBTB7B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB7B Gene:

ZBTB7B

SOURCE GeneReport for Unigene cluster for ZBTB7B Gene:

Hs.729279
genes like me logo Genes that share expression patterns with ZBTB7B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZBTB7B Gene

Orthologs for ZBTB7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB7B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBTB7B 34
  • 89.16 (n)
  • 94.95 (a)
ZBTB7B 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB7B 34
  • 88.93 (n)
  • 94.99 (a)
ZBTB7B 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb7b 34
  • 87.82 (n)
  • 91.84 (a)
Zbtb7b 16
Gm18856 35
  • 85 (a)
OneToMany
Zbtb7b 35
  • 91 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZBTB7B 34
  • 99.71 (n)
  • 100 (a)
ZBTB7B 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb7b 34
  • 86.97 (n)
  • 91 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBTB7B 35
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cpg-A 34
zebrafish
(Danio rerio)
Actinopterygii zgc63489 34
ZBTB7B 35
  • 47 (a)
OneToOne
Species where no ortholog for ZBTB7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB7B Gene

ENSEMBL:
Gene Tree for ZBTB7B (if available)
TreeFam:
Gene Tree for ZBTB7B (if available)

Paralogs for ZBTB7B Gene

(2) SIMAP similar genes for ZBTB7B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB7B: view

Variants for ZBTB7B Gene

Sequence variations from dbSNP and Humsavar for ZBTB7B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1870940 -- 155,011,887(+) GTCTA(A/G)GAGGG intron-variant
rs2242195 -- 155,016,481(-) GGTGG(C/T)GGGTA nc-transcript-variant, reference, synonymous-codon
rs3753639 -- 155,013,615(-) CTCCA(A/G)GGCCC intron-variant
rs3820225 -- 155,014,317(-) TTCAT(A/G)GAGGT intron-variant
rs4845402 -- 155,005,453(+) TGGAG(A/G)AGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB7B Gene

Variant ID Type Subtype PubMed ID
nsv1078828 CNV deletion 25765185
nsv1112556 CNV deletion 24896259
nsv1142783 CNV deletion 24896259
nsv509502 CNV insertion 20534489
nsv824775 CNV loss 20364138
nsv952212 CNV deletion 24416366

Variation tolerance for ZBTB7B Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB7B Gene

Disorders for ZBTB7B Gene

Relevant External Links for ZBTB7B

Genetic Association Database (GAD)
ZBTB7B
Human Genome Epidemiology (HuGE) Navigator
ZBTB7B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB7B

No disorders were found for ZBTB7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB7B Gene

Publications for ZBTB7B Gene

  1. Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression. (PMID: 9370309) Widom R.L. … Korn J.H. (Gene 1997) 2 3 4 65
  2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 65
  3. CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. (PMID: 19696430) Wang L. … Bosselut R. (J. Immunol. 2009) 3 22 65
  4. Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1. (PMID: 18298657) Renard E. … GalAcra P. (J. Cell. Mol. Med. 2008) 3 22 65
  5. Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. (PMID: 17698844) Kypriotou M. … GalAcra P. (J. Biol. Chem. 2007) 3 22 65

Products for ZBTB7B Gene

Sources for ZBTB7B Gene

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