Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZBTB7B Gene

protein-coding   GIFtS: 51
GCID: GC01P154975

Zinc Finger And BTB Domain Containing 7B

(Previous name: zinc finger protein 67 homolog (mouse))
(Previous symbol: ZFP67)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Finger And BTB Domain Containing 7B1 2     Zinc Finger Protein 67 Homolog (Mouse)1
ZFP671 2 3     THPOK2
Zinc Finger And BTB Domain Containing 151 2     ZFP-672
Krueppel-Related Zinc Finger Protein CKrox2 3     c-KROX2
Zinc Finger Protein 67 Homolog2 3     hcKROX2
Zinc Finger Protein 857B2 3     Zinc Finger And BTB Domain-Containing Protein 7B2
Zinc Finger Protein Th-POK2 3     Zfp-673
ZBTB152 3     hcKrox3
ZNF857B2 3     Zinc Finger And BTB Domain-Containing Protein 153
T-Helper-Inducing POZ/Krueppel-Like Factor2 3     

External Ids:    HGNC: 186681   Entrez Gene: 510432   Ensembl: ENSG000001606857   OMIM: 6076465   UniProtKB: O151563   

Export aliases for ZBTB7B gene to outside databases

Previous GC identifers: GC01P151790 GC01P153242 GC01P126337


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ZBTB7B Gene:
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment
of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence
causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively
spliced transcript variants have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for ZBTB7B Gene:
ZBTB7B (zinc finger and BTB domain containing 7B) is a protein-coding gene. GO annotations related to this gene include protein homodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZBTB21.

UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156
Function: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell
precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment.
Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages
correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or
class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also
function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity)

Gene Wiki entry for ZBTB7B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB7B gene promoter:
         CREB   AML1a   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB7B promoter sequence
   Search Chromatin IP Primers for ZBTB7B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

ZBTB7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB7B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154975:  view genomic region     (about GC identifiers)

Start:
154,975,112 bp from pter      End:
154,990,999 bp from pter
Size:
15,888 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 7B  
Size: 539 amino acids; 58027 Da
Sequence caution: Sequence=CAH18158.1; Type=Erroneous initiation;
Secondary accessions: B4E3K5 D3DV83 J3KQQ3 Q68DR2 Q96EP2
Alternative splicing: 2 isoforms:  O15156-1   O15156-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZBTB7B: NX_O15156

Explore proteomics data for ZBTB7B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZBTB7B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239335.1  NP_001243384.1  

    ENSEMBL proteins: 
     ENSP00000357411   ENSP00000292176   ENSP00000406286   ENSP00000438647  

    ZBTB7B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for ZBTB7B
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZBTB7B
    GenScript Custom Purified and Recombinant Proteins Services for ZBTB7B
    Novus Biologicals ZBTB7B Proteins
    Novus Biologicals ZBTB7B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZBTB7B

     
    Search eBioscience for Proteins for ZBTB7B 

     
    antibodies-online proteins for ZBTB7B (5 products) 

     
    antibodies-online peptides for ZBTB7B

    ZBTB7B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ZBTB7B (Th-POK)
    OriGene Antibodies for ZBTB7B
    OriGene Custom Antibody Services for ZBTB7B
    Novus Biologicals ZBTB7B Antibodies
    Search for Antibodies for ZBTB7B at Abcam
    Cloud-Clone Corp. Antibodies for ZBTB7B
    ThermoFisher Antibody for ZBTB7B
    antibodies-online antibodies for ZBTB7B (47 products) 

    ZBTB7B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZBTB7B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZBTB7B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZBTB7B
    Cloud-Clone Corp. CLIAs for ZBTB7B
    Search eBioscience for ELISAs for ZBTB7B 
    antibodies-online kits for ZBTB7B (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry O15156

    ProtoNet protein and cluster: O15156

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 4 C2H2-type zinc fingers


    Find genes that share domains with ZBTB7B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT7B_HUMAN, O15156
    Function: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell
    precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment.
    Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages
    correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or
    class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also
    function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZBTB7B           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 18 alleles(MGI details for Zbtb7b):
     hematopoietic system  immune system  no phenotypic analysis  normal  reproductive system 

    Find genes that share phenotypes with ZBTB7B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ZBTB7B: Zbtb7btm1Itan Zbtb7btm1.2Litt Zbtb7btm1.1Rbo

       genOway: Develop your customized and physiologically relevant rodent model for ZBTB7B

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZBTB7B:
    hsa-mir-106b-5p (MIRT044285), hsa-mir-335-5p (MIRT018753), hsa-mir-1226-3p (MIRT036479)

    Block miRNA regulation of human, mouse, rat ZBTB7B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBTB7B (see all 79):
    hsa-miR-323-3p hsa-miR-3194-5p hsa-miR-3938 hsa-miR-1321 hsa-miR-3607-3p hsa-miR-1914* hsa-miR-3622b-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidZBTB7B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZBTB7B
    Predesigned siRNA for gene silencing in human, mouse, rat ZBTB7B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZBTB7B

    Clone
    Products:
         
    OriGene clones in human, mouse for ZBTB7B (see all 6)
    OriGene ORF clones in mouse, rat for ZBTB7B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZBTB7B (NM_015872)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB7B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB7B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZBTB7B
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZBTB7B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB7B

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13458 VA1-13702) for ZBTB7B 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZBT7B_HUMAN, O15156: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with ZBTB7B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including ZBTB7B: 
              T Helper Cell Differentiation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ZBTB7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for ZBTB7B (O151562, 3 ENSP000002921764) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPH1Q925983, ENSP000003186874I2D: score=1 STRING: ENSP00000318687
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    MYBBP1AQ9BQG03, ENSP000003709684I2D: score=1 STRING: ENSP00000370968
    PRPF8Q6P2Q93, ENSP000003043504I2D: score=1 STRING: ENSP00000304350
    SP1P080473, ENSP000003293574I2D: score=1 STRING: ENSP00000329357
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS7937772
    GO:0007275multicellular organismal development IEA--
    GO:0007398ectoderm development TAS7937772
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with ZBTB7B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB7B (ZBT7B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZBTB7B gene (2 alternative transcripts): 
    NM_001252406.2  NM_001256455.1  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368426(uc001fgj.4 uc009wpa.3 uc001fgk.4 uc010peq.2 uc001fgl.4)
    ENST00000487542 ENST00000461530 ENST00000483226 ENST00000292176 ENST00000417934
    ENST00000535420
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZBTB7B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBTB7B (see all 79):
    hsa-miR-323-3p hsa-miR-3194-5p hsa-miR-3938 hsa-miR-1321 hsa-miR-3607-3p hsa-miR-1914* hsa-miR-3622b-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidZBTB7B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZBTB7B
    Predesigned siRNA for gene silencing in human, mouse, rat ZBTB7B
    Clone
    Products:
         
    OriGene clones in human, mouse for ZBTB7B (see all 6)
    OriGene ORF clones in mouse, rat for ZBTB7B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZBTB7B (NM_015872)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB7B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB7B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZBTB7B
    OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB7B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZBTB7B
      QuantiTect SYBR Green Assays in human, mouse, rat ZBTB7B
      QuantiFast Probe-based Assays in human, mouse, rat ZBTB7B
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13458 VA1-13702) for ZBTB7B 

    Selected AceView cDNA sequences (see all 103):

    AL045086 BC012070 BX114870 BE264814 AA302854 BM710078 CB053797 BM801567 
    AA985620 BG742178 BF510901 AL541093 AW663133 BM717964 CA426792 AI640907 
    CK820290 AA676723 BI766940 BG336966 CD245481 BG675141 AK127884 CF139383 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7B (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b
    SP1:              -           -     -     -           -                                                   
    SP2:                          -           -     -     -                                                   
    SP3:                          -     -     -           -                                                   
    SP4:                          -     -     -     -     -                                                   
    SP5:                          -                                                                           


    ECgene alternative splicing isoforms for ZBTB7B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZBTB7B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCATTTGCA
    ZBTB7B Expression
    About this image


    ZBTB7B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebellum
     
     Colon (Gastrointestinal Tract)
    ZBTB7B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB7B Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including ZBTB7B: 
              T Helper Cell Differentiation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ZBTB7B
    OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB7B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZBTB7B
    QuantiTect SYBR Green Assays in human, mouse, rat ZBTB7B
    QuantiFast Probe-based Assays in human, mouse, rat ZBTB7B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB7B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB7B gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb7b1 , 5 zinc finger and BTB domain containing 7B1, 5 87.82(n)1
    91.84(a)1
      3 (39.09 cM)5
    227241  NM_009565.41  NP_033591.21 
     893776445 
    African clawed frog
    (Xenopus laevis)
    Amphibia cpg-A2 POZ/zinc finger protein, champignon 79.95(n)    AB029074.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc634892 hypothetical protein MGC63489 75.29(n)   393602  BC057297.1 


    ENSEMBL Gene Tree for ZBTB7B (if available)
    TreeFam Gene Tree for ZBTB7B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZBTB7B gene
    ZBTB212  ZBTB382  ZBTB332  ZBTB142  ZBTB7C2  ZBTB7A2  ZBTB42  
    2 SIMAP similar genes for ZBTB7B using alignment to 1 protein entry:     ZBT7B_HUMAN:
    ZBTB7C    ZBTB7A

    Find genes that share paralogs with ZBTB7B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZBTB7B (see all 285)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127299861,2
    C,H--154973218(+) CCGCCT/GAGCCC 5 -- us2k13Minor allele frequency- G:0.00EA NS 298
    rs1843422571,2
    --154973242(+) TCACCA/CGGCCT 5 -- us2k10--------
    rs1130568781,2
    C--154973294(+) CTGGACCCCAC/-
            
    ACGGC
    3 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs112829801,2
    C--154973295(+) TGGAC-/CCC/  
      CCCACC
    GGCTC
    7 -- us2k1 cds11NA 2
    rs1887802201,2
    --154973392(+) GACGAC/TAGGAA 5 -- us2k10--------
    rs1475599951,2
    --154973608(+) AGAGG-/GAGAGAG 5 -- us2k10--------
    rs1158838101,2
    --154973707(+) CGCCGA/CCCATT 5 -- us2k10--------
    rs1812415531,2
    --154973718(+) GTGGTC/TCAACA 5 -- us2k10--------
    rs1440221381,2
    C--154973984(+) TTATCC/TCGGTC 5 -- us2k10--------
    rs1838689451,2
    --154974586(+) CACTGA/CCCCCT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZBTB7B (154975112 - 154990999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZBTB7B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509502CNV Insertion20534489
    nsv824775CNV Loss20364138
    nsv872454CNV Loss21882294
    nsv872453CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB7B
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB7B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607646    OMIM disorders: --


    Find genes that share disorders with ZBTB7B           About GenesLikeMe

    Genetic Association Database (GAD): ZBTB7B
    Human Genome Epidemiology (HuGE) Navigator: ZBTB7B (2 documents)

    Export disorders for ZBTB7B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZBTB7B gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with ZBTB7B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression. (PubMed id 9370309)1, 2, 3 Widom R.L.... Korn J.H. (Gene 1997)
    2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. (PubMed id 7937772)1, 3 GalAcra P....Karsenty G. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    6. Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. (PubMed id 17698844)1, 9 Kypriotou M....GalAcra P. (J. Biol. Chem. 2007)
    7. CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. (PubMed id 19696430)1, 9 Wang L. and Bosselut R. (J. Immunol. 2009)
    8. Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1. (PubMed id 18298657)1, 9 Renard E....GalAcra P. (J. Cell. Mol. Med. 2008)
    9. Th inducing POZ-Kruppel Factor (ThPOK) is a key regulator of the immune response since the early steps of colorectal carcinogenesis. (PubMed id 23349906)1 Mariani F....Roncucci L. (PLoS ONE 2013)
    10. Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer. (PubMed id 23315079)1 Muroi S....Taniuchi I. (J. Immunol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51043 HGNC: 18668 AceView: ZFP67 Ensembl:ENSG00000160685 euGenes: HUgn51043
    ECgene: ZBTB7B H-InvDB: ZBTB7B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZBTB7B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZBTB7B gene:
    Search GeneIP for patents involving ZBTB7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for ZBTB7B (Th-POK)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ZBTB7B   OriGene RNAi products in human, mouse, rat for ZBTB7B  
     OriGene qPCR primer pairs and template standards for ZBTB7B   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZBTB7B  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB7B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZBTB7B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZBTB7B   OriGene Custom Protein Services for ZBTB7B  

     
     
     Block miRNA regulation of human, mouse, rat ZBTB7B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZBTB7B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB7B Predesigned siRNA for gene silencing in human, mouse, rat ZBTB7B
     QuantiFast Probe-based Assays in human, mouse, rat ZBTB7B QuantiTect SYBR Green Assays in human, mouse, rat ZBTB7B
     PCR Arrays including human, mouse, rat ZBTB7B Search Chromatin IP Primers for ZBTB7B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZBTB7B  Search GeneGlobe Interaction Network for ZBTB7B
     Regulatory tfbs in ZBTB7B promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZBTB7B GenScript cDNA clones with any tag delivered in your preferred vector for ZBTB7B
     GenScript Custom Assay Services for ZBTB7B GenScript Custom overexpressing Cell Line Services for ZBTB7B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZBTB7B (ZBT7B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for ZBTB7B
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZBTB7B antibodies
     ZBTB7B proteins
     ZBTB7B lysates
     Search for Antibodies for ZBTB7B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ZBTB7B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZBTB7B
     Antibodies for ZBTB7B
     ELISAs for ZBTB7B
     CLIAs for ZBTB7B



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZBTB7B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB7B
     SwitchGear 3'UTR luciferase reporter plasmids for ZBTB7B
     SwitchGear Promoter luciferase reporter plasmids for ZBTB7B
     ThermoFisher Antibody for ZBTB7B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB7B
     Browse compounds at ApexBio
     Search Addgene for plasmids for ZBTB7B
      Search eBioscience for proteins for ZBTB7B
      Search eBioscience for elisas for ZBTB7B
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ZBTB7B
     antibodies-online antibodies for ZBTB7B (47 products)
     antibodies-online kits for ZBTB7B (5 products)
     antibodies-online peptides for ZBTB7B
     antibodies-online proteins for ZBTB7B (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZBTB7B gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4