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Aliases & Descriptions for ZBTB7B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp686G01254 2 | | OTTHUMP00000035544 2 | | OTTHUMP00000035545 2 | | THPOK 2 | | ZBTB15 1, 2, 3 | | ZFP67 2, 3 | | ZNF857B 1, 2 | | Zfp-67 3 | | c-Krox 1, 2 | | hcKrox 1, 2, 3 |
| | | Descriptions |
|---|
| Krueppel-related zinc finger protein cKrox 3 | | T-helper-inducing POZ/Krueppel-like factor 3 | | Zinc finger and BTB domain-containing protein 15 3 | | Zinc finger protein 67 homolog 2, 3 | | Zinc finger protein Th-POK 3 | | kruppel-related zinc finger protein hcKrox 2 | | zinc finger and BTB domain containing 15 2 | | zinc finger and BTB domain containing 7B 2 | | zinc finger protein 67 homolog (mouse) 1 |
|
| | Search outside databases for aliases for ZBTB7B genePrevious GC identifer: GC01P151790 |
Summaries for ZBTB7B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ZBTB7B: ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g., COL1A1; MIM 120150) and has a role in development.[supplied by OMIM] UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156Function: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity)Gene Wiki entry for ZBTB7B |
Genomic Location for ZBTB7B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ZBTB7B gene 
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.2ZBTB7B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P153242:
(about GC identifiers)
Start:
|
153,241,736 bp from pter |
End:
|
153,257,623 bp from pter |
Size:
|
15,888 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for ZBTB7B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 7B Size: 539 amino acids; 58027 Da
Subcellular location: Nucleus
Secondary accessions: Q68DR2 Q96EP2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056956.2
ENSEMBL proteins: ENSP00000357411 ENSP00000292176
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ZBTB7B: Assays for ZBTB7B: | Protein
Domains/ Families for ZBTB7B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O15156
ProtoNet protein and cluster: O15156 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 4 C2H2-type zinc fingers | Gene Function for ZBTB7B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015872
Applied Biosystems Silencer® siRNAs for ZBTB7B
Sigma-Aldrich siRNA and siRNA Panels for ZBTB7B  Sigma-Aldrich shRNA for ZBTB7B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015872                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015872                                  untagged cDNA clone in CMV expression vector: NM_015872 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015872
UniProtKB/Swiss-Prot: ZBT7B_HUMAN, O15156Function: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity)5 MGI mutant phenotypes (inferred from 12 alleles ) (MGI details for Zbtb7b):
5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ZBTB7B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/8 Interacting proteins for ZBTB7B (O151562 ENSP000003574113) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for ZBTB7B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ZBTB7B
|
Transcripts for ZBTB7B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015872
Sigma-Aldrich siRNA and siRNA Panels for ZBTB7B  Sigma-Aldrich shRNA for ZBTB7B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015872 REFSEQ mRNAs for ZBTB7B gene: NM_015872.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015872               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015872                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015872                                  untagged cDNA clone in CMV expression vector: NM_015872  Additional cDNA sequence: AF007833.1 AK127884.1 AK291619.1 AK304762.1 BC012070.1 BC128176.1 CR749303.1 12 DOTS entries: DT.106370 DT.91828569 DT.95167263 DT.92030781 DT.121414061 DT.100813869 DT.121413799 DT.121413978 DT.75189212 DT.95368738 DT.40132993 DT.91700072 24/103 AceView cDNA sequences (see all 103
):BM801567 AA302854 AW663133 BC012070 BF510901 CB053797 BE264814 AA985620 AL541093 BG742178 BM717964 AI640907 BM710078 CA426792 BX114870 AL045086 AK127884 C04237 CD516754 NM_015872 BQ879134 AA337193 BG336966 CD245481
highest scoring ESTs for ZBTB7B:AA676723 AF007833 AA302853 AA302854 AA337193 AA918560 AI475643 AK127884 AL568730 AW673776 Unigene Cluster for ZBTB7B: Zinc finger and BTB domain containing 7B Hs.700874 [show with all ESTs]Unigene Representative Sequence: NM_015872
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7B (see all 9
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | · | 7g | ^ | 8a | · | 8b | |
| SP1: | |   | |   | - |   | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ZBTB7B
2 Ensembl transcripts including schematic representations: ENST00000368426
ENST00000292176
|
Expression for ZBTB7B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZBTB7B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB7B
1 / 2 / 3 7 probe-sets matching ZBTB7B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCCATTTGCA
SOURCE GeneReport for Unigene cluster: Hs.700874
|
Orthologs for ZBTB7B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZBTB7B gene from 5/7 species (see all 7
)
About this table Species with no ortholog for ZBTB7B
ENSEMBL Gene Tree for ZBTB7B | Paralogs for ZBTB7B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ZBTB7B gene
- ZBTB242 ZBTB7C2 ZBTB7A2 ZBTB442
|
SNPs/Variants for ZBTB7B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ZBTB7B (up to first 250kb)
|
Disorders & Mutations for ZBTB7B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607646
|
Medical News for ZBTB7B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ZBTB7B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for ZBTB7B gene (see all 14
):- Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression. (PubMed id 9370309)2, 3, 4 Widom R.L.... Korn J.H. (1997)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. (PubMed id 7937772)2, 3 Galera P....Karsenty G. (1994)
- Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. (PubMed id 17698844)1, 3 Kypriotou M....Galera P. (2007)
- Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1. (PubMed id 18298657)1, 3 Renard E....GalAcra P. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for ZBTB7B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZBTB7B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZBTB7B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB7B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ZBTB7B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ZBTB7B:

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Incremental update: 13 Oct 2009
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