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ZBTB7A Gene

protein-coding   GIFtS: 52
GCID: GC19M004045

Zinc Finger And BTB Domain Containing 7A

(Previous name: zinc finger and BTB domain containing 7)
(Previous symbol: ZBTB7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 7A1 2     TIP212 3
ZBTB71 2 3     ZNF857A2 3
FBI12 3 5     HIV-1 1st-Binding Protein 12 3
LRF2 3 5     POK Erythroid Myeloid Ontogenic Factor2 3
HIV-1 Inducer Of Short Transcripts Binding Protein1 2     POZ And Krueppel Erythroid Myeloid Ontogenic Factor2 3
Lymphoma Related Factor1 2     TTF-I-Interacting Peptide 212 3
Factor Binding IST Protein 12 3     Zinc Finger And BTB Domain Containing 71
Factor That Binds To Inducer Of Short Transcripts Protein 12 3     pokemon2
Leukemia/Lymphoma-Related Factor2 3     Zinc Finger And BTB Domain Containing 7A, HIV-1 Inducer Of Short
Transcripts Binding Protein2
Zinc Finger Protein 857A2 3     Zinc Finger And BTB Domain-Containing Protein 7A2
FBI-12 3     Pokemon3

External Ids:    HGNC: 180781   Entrez Gene: 513412   Ensembl: ENSG000001789517   OMIM: 6058785   UniProtKB: O953653   

Export aliases for ZBTB7A gene to outside databases

Previous GC identifers: GC19M004000 GC19M004001 GC19M003809


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZBTB7A Gene:
ZBTB7A (zinc finger and BTB domain containing 7A) is a protein-coding gene. Diseases associated with ZBTB7A include hiv-1, and leukemia. GO annotations related to this gene include histone acetyltransferase binding. An important paralog of this gene is ZBTB21.

UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365
Function: Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by
repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the
CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus
sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity)

Gene Wiki entry for ZBTB7A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB7A gene promoter:
         CREB   c-Rel   Sp1   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB7A promoter sequence
   Search Chromatin IP Primers for ZBTB7A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB7A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ZBTB7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB7A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004045:  view genomic region     (about GC identifiers)

Start:
4,044,362 bp from pter      End:
4,066,943 bp from pter
Size:
22,582 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 7A  
Size: 584 amino acids; 61439 Da
Subunit: Interacts with BCL6 (By similarity)
Sequence caution: Sequence=AAB58414.1; Type=Frameshift; Positions=8, 324;
2 PDB 3D structures from and Proteopedia for ZBTB7A:
2IF5 (3D)        2NN2 (3D)    
Secondary accessions: D6W619 O00456 Q14D41 Q5XG86

Explore the universe of human proteins at neXtProt for ZBTB7A: NX_O95365

Explore proteomics data for ZBTB7A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZBTB7A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056982.1  
    ENSEMBL proteins: 
     ENSP00000323670   ENSP00000471865  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry O95365

    ProtoNet protein and cluster: O95365

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 4 C2H2-type zinc fingers


    ZBTB7A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT7A_HUMAN, O95365
    Function: Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by
    repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the
    CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus
    sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS15337766
    GO:0005515protein binding ----
    GO:0035035histone acetyltransferase binding ISS15337766
    GO:0046872metal ion binding IEA--
         
    ZBTB7A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB7A:
     Increased cilium length after  

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zbtb7a):
     hematopoietic system  immune system  mortality/aging 

    ZBTB7A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zbtb7atm1Ppp for ZBTB7A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZBTB7A
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    miRNA
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    miRTarBase miRNAs that target ZBTB7A:
    hsa-mir-93-5p (MIRT048760), hsa-mir-222-3p (MIRT046756)

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    Selected qRT-PCR Assays for microRNAs that regulate ZBTB7A (see all 95):
    hsa-miR-132* hsa-miR-520f hsa-miR-520e hsa-miR-376b hsa-miR-106a hsa-miR-30d hsa-miR-3653 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidZBTB7A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB7A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZBT7A_HUMAN, O95365: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZBTB7A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB7A
    Interactions:

        GeneGlobe Interaction Network for ZBTB7A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for ZBTB7A (O953653 ENSP000003236704) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC3O153793, ENSP000003029674I2D: score=1 STRING: ENSP00000302967
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    SP4Q024463, ENSP000002225844I2D: score=1 STRING: ENSP00000222584
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation IEA--
    GO:0045892negative regulation of transcription, DNA-templated ISS15337766

    ZBTB7A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB7A (ZBT7A)

    1 Novoseek inferred chemical compound relationship for ZBTB7A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 43 6 9973611 (2), 15337766 (1), 18682402 (1)



    ZBTB7A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZBTB7A gene: 
    NM_015898.2  

    Unigene Cluster for ZBTB7A:

    Zinc finger and BTB domain containing 7A
    Hs.591384  [show with all ESTs]
    Unigene Representative Sequence: NM_015898
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322357(uc002lzh.3 uc002lzi.3) ENST00000601588
    miRNA
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    Block miRNA regulation of human, mouse, rat ZBTB7A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBTB7A (see all 95):
    hsa-miR-132* hsa-miR-520f hsa-miR-520e hsa-miR-376b hsa-miR-106a hsa-miR-30d hsa-miR-3653 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidZBTB7A 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZBTB7A
      QuantiFast Probe-based Assays in human, mouse, rat ZBTB7A

    Additional mRNA sequence: 

    AF000561.1 AF097916.1 AL390151.1 BC019108.1 BC080608.1 BC084568.1 BC113511.1 

    6 DOTS entries:

    DT.40216451  DT.75190622  DT.91741935  DT.92047208  DT.97835598  DT.95168110 

    Selected AceView cDNA sequences (see all 339):

    BM709026 BM685110 AI498511 BE464093 BM354098 F04371 BM128630 CA848179 
    CB156229 AI918876 AW138580 AW445134 BM273144 BF064025 BU170108 AI004617 
    AI568395 BM930392 AW511323 AI675792 N22539 BC019108 BM853431 AI416999 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBTB7A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCGTGCACA
    ZBTB7A Expression
    About this image

    ZBTB7A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB7A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591384

    UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365
    Tissue specificity: Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's
    corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at
    protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate
    and bladder carcinomas (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB7A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb7a1 , 5 zinc finger and BTB domain containing 7a1, 5 85.2(n)1
    90.59(a)1
      10 (39.72 cM)5
    169691  NM_010731.31  NP_034861.31 
     811352205 
    chicken
    (Gallus gallus)
    Aves ZBTB7A1 zinc finger and BTB domain containing 7A 75.26(n)
    74.21(a)
      395411  NM_204680.1  NP_990011.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB7A6
    zinc finger and BTB domain containing 7A
    65(a)
    1 ↔ 1
    AAWZ02037057(2728-3246)
    zebrafish
    (Danio rerio)
    Actinopterygii zbtb7a1 zinc finger and BTB domain containing 7a 62.53(n)
    58.17(a)
      565670  XM_005170529.1  XP_005170586.1 


    ENSEMBL Gene Tree for ZBTB7A (if available)
    TreeFam Gene Tree for ZBTB7A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBTB7A gene
    ZBTB212  ZBTB382  ZBTB332  ZBTB142  ZBTB7C2  ZBTB7B2  ZBTB42  
    6 SIMAP similar genes for ZBTB7A using alignment to 3 protein entries:     ZBT7A_HUMAN (see all proteins):
    ZNF    KBTBD3    ZNF137P    ZNF323    ZBTB7C    ZBTB7B

    ZBTB7A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZBTB7A (see all 446)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387420861,2
    --4045406(+) GTGAAC/TGCAGC 1 -- ut310--------
    rs104140351,2
    C,F,H--4045434(+) GCCCCA/GGGGGA 1 -- ut31 ese3 trp38Minor allele frequency- G:0.03NS WA 1284
    rs134371,2
    C,F--4045518(+) CATCCC/G/TGTAGA 2 -- ut31 ese317EA MN NA WA CSA 2245
    rs1412653591,2
    --4045677(+) TCAGTA/GCAGCA 1 -- ut310--------
    rs1872882881,2
    --4045714(+) TAGCAC/TTGCAT 1 -- ut310--------
    rs2011872411,2
    C--4045773(+) AACCCC/TGGCCC 1 -- ut310--------
    rs2004593331,2
    C--4045792(+) GGCCTA/GTGGCT 1 -- ut310--------
    rs104128251,2
    C,F,A,H--4045962(+) CCTCAG/ACAGGG 1 -- ut31 ese311Minor allele frequency- A:0.03NS EA NA WA 1568
    rs1906222271,2
    --4046209(+) TCCTGC/TCTTCG 1 -- ut310--------
    rs2004663221,2
    C--4046360(-) TTGTAA/CAAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZBTB7A (4044362 - 4066943 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZBTB7A (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670713CNV Deletion23128226
    esv2717979CNV Deletion23290073
    esv2717990CNV Deletion23290073
    esv2671159CNV Deletion23128226
    esv26783CNV Loss19812545
    dgv3666n71CNV Loss21882294
    dgv3670n71CNV Loss21882294
    dgv3667n71CNV Loss21882294
    dgv3665n71CNV Loss21882294
    dgv3672n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605878    OMIM disorders: --

    12 diseases for ZBTB7A:    
    About MalaCards
    hiv-1    leukemia    tonsillitis    brain cancer
    bladder carcinoma    chondrosarcoma    hepatocellular carcinoma    lung cancer
    prostate cancer    prostatitis    ovarian cancer    breast cancer


    ZBTB7A for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ZBTB7A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 13.9 2 9199312 (1), 15917220 (1)


    Export disorders for ZBTB7A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBTB7A gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with ZBTB7A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. (PubMed id 9973611)1, 2, 3, 9 Morrison D.J.... Hernandez N. (Nucleic Acids Res. 1999)
    2. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. (PubMed id 9927193)1, 2, 3 Davies J.M.... Zelent A. (Oncogene 1999)
    3. Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator. (PubMed id 17189472)1, 2, 9 Stogios P.J.... Prive G.G. (Protein Sci. 2007)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. (PubMed id 15662416)1, 2 Maeda T.... Pandolfi P.P. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Transcription factor FBI-1 acts as a dual regulator in adipogenesis by coordinated regulation of cyclin-A and E2F-4. (PubMed id 18368381)1, 9 Laudes M....Krone W. (J. Mol. Med. 2008)
    8. Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN). (PubMed id 18682402)1, 9 Choi W.I....Hur M.W. (J. Biol. Chem. 2008)
    9. FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB. (PubMed id 15917220)1, 9 Lee D.K....Hur M.W. (J. Biol. Chem. 2005)
    10. Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis. (PubMed id 15337766)1, 9 Liu C.J....Di Cesare P.E. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51341 HGNC: 18078 AceView: ZBTB7 Ensembl:ENSG00000178951 euGenes: HUgn51341
    ECgene: ZBTB7A H-InvDB: ZBTB7A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZBTB7A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZBTB7A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZBTB7A gene:
    Search GeneIP for patents involving ZBTB7A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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