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Aliases & Descriptions for ZBTB7A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp547O146 1, 2 | | FBI-1 1, 2, 3 | | FBI1 2, 3 | | LRF 1, 2, 3 | | MGC99631 2 | | Pokemon 3 | | TIP21 3 | | ZBTB7 2, 3 | | ZNF857A 1, 2 | | pokemon 1, 2 |
| | | Descriptions |
|---|
| Factor binding IST protein 1 3 | | Factor that binds to inducer of short transcripts protein 1 3 | | HIV-1 1st-binding protein 1 3 | | HIV-1 inducer of short transcripts binding protein 2 | | Leukemia/lymphoma-related factor 3 | | POK erythroid myeloid ontogenic factor 3 | | POZ and Krueppel erythroid myeloid ontogenic factor 3 | | TTF-I-interacting peptide 21 3 | | lymphoma related factor 2 | | zinc finger and BTB domain containing 7 1 | | zinc finger and BTB domain containing 7A 2 | zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein 2 |
|
| | Search outside databases for aliases for ZBTB7A gene |
Summaries for ZBTB7A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365Function: Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity)Gene Wiki entry for ZBTB7A |
Genomic Location for ZBTB7A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ZBTB7A gene 
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3ZBTB7A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M004000:
(about GC identifiers)
Start:
|
3,996,216 bp from pter |
End:
|
4,017,816 bp from pter |
Size:
|
21,601 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011255.14
| Proteins for ZBTB7A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 7A Size: 584 amino acids; 61439 Da
Subunit: Interacts with BCL6 (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAB58414.1; Type=Frameshift; Positions=8, 324;
PDB structure from and Proteopedia :2IF5 (3D)
 2NN2 (3D)
 
Secondary accessions: O00456 Q14D41 Q5XG86Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056982.1
ENSEMBL proteins: ENSP00000323670
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ZBTB7A: Assays for ZBTB7A: | Protein
Domains/ Families for ZBTB7A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95365
ProtoNet protein and cluster: O95365 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 4 C2H2-type zinc fingers | Gene Function for ZBTB7A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015898
Applied Biosystems Silencer® siRNAs for ZBTB7A
Sigma-Aldrich siRNA and siRNA Panels for ZBTB7A  Sigma-Aldrich shRNA for ZBTB7A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015898                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015898                                  untagged cDNA clone in CMV expression vector: NM_015898 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015898
UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365Function: Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity)3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Zbtb7a):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for ZBTB7A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for ZBTB7A 
5/6 Interacting proteins for ZBTB7A (ENSP000003236703) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for ZBTB7A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ZBTB7A 1 Novoseek chemical compound relationship for ZBTB7A gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
39.10 |
6 |
9973611 (2), 15337766 (1), 18682402 (1) |
About this table
|
Transcripts for ZBTB7A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015898
Sigma-Aldrich siRNA and siRNA Panels for ZBTB7A  Sigma-Aldrich shRNA for ZBTB7A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015898 REFSEQ mRNAs for ZBTB7A gene: NM_015898.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015898               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015898                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015898                                  untagged cDNA clone in CMV expression vector: NM_015898  Additional cDNA sequence: AF000561.1 AF097916.1 AL390151.1 BC019108.1 BC080608.1 BC084568.1 BC113511.1 6 DOTS entries: DT.40216451 DT.75190622 DT.91741935 DT.92047208 DT.97835598 DT.95168110 24/339 AceView cDNA sequences (see all 339
):BC019108 AF097916 AI817841 AI361640 BQ101035 N22539 AI818005 AI864258 R85303 AI796716 AI697817 AI361843 BM782585 BQ008623 CA848179 BE464093 BX104942 BM273144 BF438258 AI745380 AW511323 AI979111 AI470606 BF726783
highest scoring ESTs for ZBTB7A:AF000561 AI479745 AW027070 AW772640 BG700369 BG705256 BU526615 AA079326 AA156986 AA243211 Unigene Cluster for ZBTB7A: Zinc finger and BTB domain containing 7A Hs.591384 [show with all ESTs]Unigene Representative Sequence: NM_015898
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000322357
|
Expression for ZBTB7A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZBTB7A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB7A
1 / 2 / 3 11 probe-sets matching ZBTB7A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CGCGTGCACA
SOURCE GeneReport for Unigene cluster: Hs.591384
Expression variation in blood from EXPOLDB for ZBTB7A UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365Tissue specificity: Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level) |
Orthologs for ZBTB7A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZBTB7A gene from 5/7 species (see all 7
)
About this table Species with no ortholog for ZBTB7A
ENSEMBL Gene Tree for ZBTB7A | Paralogs for ZBTB7A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ZBTB7A gene
- ZBTB242 ZBTB7C2 ZBTB7B2 ZBTB442
|
SNPs/Variants for ZBTB7A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ZBTB7A (up to first 250kb)
|
Disorders & Mutations for ZBTB7A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605878
1 Novoseek disease relationship for ZBTB7A gene
About this table
|
Medical News for ZBTB7A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ZBTB7A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/26 PubMed articles for ZBTB7A gene (see all 26
):- FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. (PubMed id 9973611)1, 2, 3, 4 Morrison D.J.... Hernandez N. (1999)
- Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. (PubMed id 9927193)2, 3, 4 Davies J.M....Zelent A. (1999)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. (PubMed id 15662416)3, 4 Maeda T....Pandolfi P.P. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- Transcription factor FBI-1 acts as a dual regulator in adipogenesis by coordinated regulation of cyclin-A and E2F-4. (PubMed id 18368381)1, 3 Laudes M....Krone W. (2008)
- Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN). (PubMed id 18682402)1, 3 Choi W.I....Hur M.W. (2008)
- FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB. (PubMed id 15917220)1, 3 Lee D.K....Hur M.W. (2005)
- Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis. (PubMed id 15337766)1, 3 Liu C.J....Di Cesare P.E. (2004)
|
Search for ZBTB7A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZBTB7A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZBTB7A
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB7A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ZBTB7A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ZBTB7A:

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Incremental update: 13 Oct 2009
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