Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZBTB7A Gene

Aliases for ZBTB7A Gene

  • Zinc Finger And BTB Domain Containing 7A 2 3 5
  • Zinc Finger And BTB Domain Containing 7A, HIV-1 Inducer Of Short Transcripts Binding Protein 2 3
  • Factor That Binds To Inducer Of Short Transcripts Protein 1 3 4
  • POZ And Krueppel Erythroid Myeloid Ontogenic Factor 3 4
  • POK Erythroid Myeloid Ontogenic Factor 3 4
  • Leukemia/Lymphoma-Related Factor 3 4
  • Factor Binding IST Protein 1 3 4
  • TTF-I-Interacting Peptide 21 3 4
  • HIV-1 1st-Binding Protein 1 3 4
  • Zinc Finger Protein 857A 3 4
  • Lymphoma Related Factor 2 3
  • Pokemon 3 4
  • ZNF857A 3 4
  • ZBTB7 3 4
  • FBI-1 3 4
  • TIP21 3 4
  • FBI1 3 4
  • LRF 3 4
  • HIV-1 Inducer Of Short Transcripts Binding Protein 3
  • Zinc Finger And BTB Domain-Containing Protein 7A 3
  • Zinc Finger And BTB Domain Containing 7 2

External Ids for ZBTB7A Gene

Previous HGNC Symbols for ZBTB7A Gene

  • ZBTB7

Previous GeneCards Identifiers for ZBTB7A Gene

  • GC19M004000
  • GC19M004001
  • GC19M003809

Summaries for ZBTB7A Gene

GeneCards Summary for ZBTB7A Gene

ZBTB7A (Zinc Finger And BTB Domain Containing 7A) is a Protein Coding gene. GO annotations related to this gene include histone acetyltransferase binding. An important paralog of this gene is ZBTB7C.

UniProtKB/Swiss-Prot for ZBTB7A Gene

  • Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5-[GA][CA]GACCCCCCCCC-3 (By similarity).

Gene Wiki entry for ZBTB7A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB7A Gene

Genomics for ZBTB7A Gene

Regulatory Elements for ZBTB7A Gene

Enhancers for ZBTB7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZBTB7A on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB7A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB7A Gene

Chromosome:
19
Start:
4,043,303 bp from pter
End:
4,066,945 bp from pter
Size:
23,643 bases
Orientation:
Minus strand

Genomic View for ZBTB7A Gene

Genes around ZBTB7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB7A Gene

Proteins for ZBTB7A Gene

  • Protein details for ZBTB7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95365-ZBT7A_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 7A
    Protein Accession:
    O95365
    Secondary Accessions:
    • D6W619
    • O00456
    • Q14D41
    • Q5XG86

    Protein attributes for ZBTB7A Gene

    Size:
    584 amino acids
    Molecular mass:
    61439 Da
    Quaternary structure:
    • Interacts with BCL6.
    SequenceCaution:
    • Sequence=AAB58414.1; Type=Frameshift; Positions=8, 324; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB7A Gene

neXtProt entry for ZBTB7A Gene

Post-translational modifications for ZBTB7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB7A Gene

Domains & Families for ZBTB7A Gene

Gene Families for ZBTB7A Gene

Protein Domains for ZBTB7A Gene

Suggested Antigen Peptide Sequences for ZBTB7A Gene

Graphical View of Domain Structure for InterPro Entry

O95365

UniProtKB/Swiss-Prot:

ZBT7A_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB7A: view

Function for ZBTB7A Gene

Molecular function for ZBTB7A Gene

UniProtKB/Swiss-Prot Function:
Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5-[GA][CA]GACCCCCCCCC-3 (By similarity).

Gene Ontology (GO) - Molecular Function for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding ISS 15337766
GO:0005515 protein binding IPI 24514149
GO:0035035 histone acetyltransferase binding ISS 15337766
genes like me logo Genes that share ontologies with ZBTB7A: view
genes like me logo Genes that share phenotypes with ZBTB7A: view

Animal Models for ZBTB7A Gene

MGI Knock Outs for ZBTB7A:

Animal Model Products

CRISPR Products

miRNA for ZBTB7A Gene

miRTarBase miRNAs that target ZBTB7A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB7A Gene

Localization for ZBTB7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB7A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB7A Gene COMPARTMENTS Subcellular localization image for ZBTB7A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB7A: view

Pathways & Interactions for ZBTB7A Gene

SuperPathways for ZBTB7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0045670 regulation of osteoclast differentiation IEA --
genes like me logo Genes that share ontologies with ZBTB7A: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB7A Gene

Drugs & Compounds for ZBTB7A Gene

(1) Drugs for ZBTB7A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZBTB7A: view

Transcripts for ZBTB7A Gene

Unigene Clusters for ZBTB7A Gene

Zinc finger and BTB domain containing 7A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7A Gene

No ASD Table

Relevant External Links for ZBTB7A Gene

GeneLoc Exon Structure for
ZBTB7A
ECgene alternative splicing isoforms for
ZBTB7A

Expression for ZBTB7A Gene

mRNA expression in normal human tissues for ZBTB7A Gene

Protein differential expression in normal tissues from HIPED for ZBTB7A Gene

This gene is overexpressed in Pancreas (14.7), Adrenal (13.0), and Peripheral blood mononuclear cells (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB7A Gene



Protein tissue co-expression partners for ZBTB7A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB7A Gene:

ZBTB7A

SOURCE GeneReport for Unigene cluster for ZBTB7A Gene:

Hs.591384

mRNA Expression by UniProt/SwissProt for ZBTB7A Gene:

O95365-ZBT7A_HUMAN
Tissue specificity: Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassles corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level).
genes like me logo Genes that share expression patterns with ZBTB7A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZBTB7A Gene

Orthologs for ZBTB7A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB7A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBTB7A 34
  • 89.48 (n)
  • 93.28 (a)
ZBTB7A 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB7A 34
  • 92.84 (n)
  • 94.58 (a)
ZBTB7A 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb7a 34
  • 85.2 (n)
  • 90.59 (a)
Zbtb7a 16
Zbtb7a 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBTB7A 34
  • 99.83 (n)
  • 100 (a)
ZBTB7A 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb7a 34
  • 84.49 (n)
  • 89.88 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBTB7A 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB7A 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB7A 34
  • 75.26 (n)
  • 74.21 (a)
ZBTB7A 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB7A 35
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zbtb7a 34
  • 62.53 (n)
  • 58.17 (a)
zbtb7a 35
  • 45 (a)
OneToOne
Species where no ortholog for ZBTB7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB7A Gene

ENSEMBL:
Gene Tree for ZBTB7A (if available)
TreeFam:
Gene Tree for ZBTB7A (if available)

Paralogs for ZBTB7A Gene

(6) SIMAP similar genes for ZBTB7A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZBTB7A: view

Variants for ZBTB7A Gene

Sequence variations from dbSNP and Humsavar for ZBTB7A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3170370 -- 4,045,195(-) AGTGG(A/G)GGCGA downstream-variant-500B, utr-variant-3-prime
rs3745985 -- 4,054,704(+) GGCGG(C/T)GGCCG reference, missense
rs3760904 -- 4,055,508(+) cacca(C/T)gttgg intron-variant, upstream-variant-2KB
rs10535792 -- 4,046,433(+) CTCGC(-/T)TTTTT utr-variant-3-prime
rs10605999 -- 4,053,514(+) GTGTG(-/TG)CGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB7A Gene

Variant ID Type Subtype PubMed ID
dgv6231n54 CNV gain+loss 21841781
esv2670713 CNV deletion 23128226
esv2671159 CNV deletion 23128226
esv26783 CNV loss 19812545
esv2717979 CNV deletion 23290073
esv2717990 CNV deletion 23290073
nsv1071500 CNV deletion 25765185
nsv1121966 CNV deletion 24896259
nsv1126508 CNV deletion 24896259
nsv1133440 CNV deletion 24896259
nsv1136269 CNV deletion 24896259
nsv470115 CNV loss 18288195
nsv578435 CNV loss 21841781
nsv578436 CNV loss 21841781
nsv578441 CNV gain+loss 21841781
nsv828402 CNV gain 20364138
nsv828403 CNV loss 20364138
nsv953949 CNV deletion 24416366

Variation tolerance for ZBTB7A Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB7A Gene

Disorders for ZBTB7A Gene

Relevant External Links for ZBTB7A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB7A

No disorders were found for ZBTB7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB7A Gene

Publications for ZBTB7A Gene

  1. FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. (PMID: 9973611) Morrison D.J. … Hernandez N. (Nucleic Acids Res. 1999) 2 3 4 22 65
  2. Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator. (PMID: 17189472) Stogios P.J. … Prive G.G. (Protein Sci. 2007) 3 4 22 65
  3. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. (PMID: 9927193) Davies J.M. … Zelent A. (Oncogene 1999) 2 3 4 65
  4. Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A). (PMID: 19471103) Choi W.I. … Hur M.W. (Cell. Physiol. Biochem. 2009) 3 22 65
  5. Transcription factor FBI-1 acts as a dual regulator in adipogenesis by coordinated regulation of cyclin-A and E2F-4. (PMID: 18368381) Laudes M. … Krone W. (J. Mol. Med. 2008) 3 22 65

Products for ZBTB7A Gene

Sources for ZBTB7A Gene

Content