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ZBTB7A Gene

protein-coding   GIFtS: 54

GC19M004000
zinc finger and BTB domain containing 7A
(Previous name: zinc finger and BTB domain containing 7 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZBTB7)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp547O146 1, 2
FBI-1 1, 2, 3
FBI1 2, 3
LRF 1, 2, 3
MGC99631 2
Pokemon 3
TIP21 3
ZBTB7 2, 3
ZNF857A 1, 2
pokemon 1, 2
Descriptions
Factor binding IST protein 1 3
Factor that binds to inducer of short transcripts protein 1 3
HIV-1 1st-binding protein 1 3
HIV-1 inducer of short transcripts binding protein 2
Leukemia/lymphoma-related factor 3
POK erythroid myeloid ontogenic factor 3
POZ and Krueppel erythroid myeloid ontogenic factor 3
TTF-I-interacting peptide 21 3
lymphoma related factor 2
zinc finger and BTB domain containing 7 1
zinc finger and BTB domain containing 7A 2
zinc finger and BTB domain containing 7A, HIV-1 inducer of
short transcripts binding protein 2
External Ids
HGNC: 180781
Entrez Gene: 513412
UniProtKB: O953653
Ensembl: ENSG000001789517
Search outside databases for aliases for ZBTB7A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365
Function: Plays a key role in the instruction of early lymphoid progenitors to develop into B
lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the
transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A
transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By
similarity)

Gene Wiki entry for ZBTB7A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB7A gene  

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ZBTB7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004000:     (about GC identifiers)

Start:
3,996,216 bp from pter
End:
4,017,816 bp from pter
Size:
21,601 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011255.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 7A  
Size: 584 amino acids; 61439 Da
Subunit: Interacts with BCL6 (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAB58414.1; Type=Frameshift; Positions=8, 324;
PDB structure from and Proteopedia :
2IF5 (3D)    2NN2 (3D)    
Secondary accessions: O00456 Q14D41 Q5XG86

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_056982.1  

    ENSEMBL proteins: 
    ENSP00000323670 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Pokemon)
    Human Recombinant Proteins from Abnova (ZBTB7A)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZBTB7A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibody Arrays and Antibodies for ZBTB7A
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Pokemon), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ZBTB7A)
    Novus Biologicals Antibodies for ZBTB7A

    Assays for ZBTB7A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ


       GeneDecks  ZBTB7A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O95365

    ProtoNet protein and cluster: O95365

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 4 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB7A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB7A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015898

                  Applied Biosystems Silencer® siRNAs for ZBTB7A

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB7A  
                         Sigma-Aldrich shRNA for ZBTB7A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ZBTB7A
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015898
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015898
                                     untagged cDNA clone in CMV expression vector: NM_015898 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_015898

    UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365
    Function: Plays a key role in the instruction of early lymphoid progenitors to develop into B
    lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the
    transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A
    transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By
    similarity)

    3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zbtb7a):

    hematopoietic systemimmune systemlethality-prenatal/perinatal

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding ISS15337766
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0016564 transcription repressor activity ISS15337766
    GO:0035035 histone acetyltransferase binding ISS15337766
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  ZBTB7A 


    5/6 Interacting proteins for ZBTB7A (ENSP000003236703) via UniProtKB, MINT, and/or STRING (see all 6 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH6ENSP000002376533STRING (score=.936)
    ADH5ENSP000002964123STRING (score=.923)
    HDAC1ENSP000003626493STRING (score=.913)
    SIN3AENSP000003536223STRING (score=.911)
    BCL6ENSP000002320143STRING (score=.722)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0007275 multicellular organismal development IEA--
    GO:0030154 cell differentiation IEA--
    GO:0045892 negative regulation of transcription, DNA-dependent ISS15337766
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB7A
    1 Novoseek chemical compound relationship for ZBTB7A gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 39.10 6 9973611 (2), 15337766 (1), 18682402 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB7A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB7A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015898

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB7A  
                         Sigma-Aldrich shRNA for ZBTB7A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_015898  

    REFSEQ mRNAs for ZBTB7A gene: 

    NM_015898.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_015898  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015898
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015898
                                     untagged cDNA clone in CMV expression vector: NM_015898 

    Additional cDNA sequence: 

    AF000561.1 AF097916.1 AL390151.1 BC019108.1 BC080608.1 BC084568.1 BC113511.1 

    6 DOTS entries:

    DT.40216451  DT.75190622  DT.91741935  DT.92047208  DT.97835598  DT.95168110 

    24/339 AceView cDNA sequences (see all 339 ):

    BC019108 AF097916 AI817841 AI361640 BQ101035 N22539 AI818005 AI864258 
    R85303 AI796716 AI697817 AI361843 BM782585 BQ008623 CA848179 BE464093 
    BX104942 BM273144 BF438258 AI745380 AW511323 AI979111 AI470606 BF726783 

    highest scoring ESTs for ZBTB7A:

    AF000561 AI479745 AW027070 AW772640 BG700369 BG705256 BU526615 AA079326 AA156986 AA243211 

    Unigene Cluster for ZBTB7A:

    Zinc finger and BTB domain containing 7A
    Hs.591384  [show with all ESTs]
    Unigene Representative Sequence: NM_015898


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000322357  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB7A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB7A

    1 / 2 / 3

    11 probe-sets matching ZBTB7A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    48692_at2, 3 U95-C 1 1.00 1.00 0.71 1.22 AL048596 0.60 1.00 0.82 1

    39540_at2, 3 U95-A 2 1.00 0.94 -0.54 0.35 AF000561 1.00 1.00 1.00 1

    39539_at*2, 3 U95-A 1 -- -- 0.71 0.78 AI684866 0.60 1.00 0.82 1

    226554_at2, 3 U133-B 1 1.00 1.00 -- -- AW445134 0.60 1.00 0.82 1

    213299_at2, 3 U133-A 1 1.00 1.00 -- -- AW027070 0.80 1.00 0.91 1

    213303_x_at2, 3 U133-A 1 0.91 1.00 -- -- AF097916 0.60 1.00 0.82 1

    219186_at*2, 3 U133-A NULL 0.00 0.00 -- -- NM_020224 0.20 1.00 0.72 1

    226554_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    213299_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    213303_x_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --

    219186_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CGCGTGCACA

    SOURCE GeneReport for Unigene cluster: Hs.591384

    Expression variation in blood from EXPOLDB for ZBTB7A

    UniProtKB/Swiss-Prot: ZBT7A_HUMAN, O95365
    Tissue specificity: Widely expressed. In normal thymus, expressed in medullary epithelial cells and
    Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal
    center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a
    subset of breast, lung, colon, prostate and bladder carcinomas (at protein level)

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZBTB7A gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZBTB7A1   -- zinc finger and BTB domain containing 7A 92.23(n)
    93.96(a)
    485048  XM_542166.2  XP_542166.2 
    chimpanzee
    (Pan troglodytes)
    ZBTB7A1   -- zinc finger and BTB domain containing 7A 99.83(n)
    100(a)
    468671  XM_524058.2  XP_524058.2 
    cow
    (Bos taurus)
    ZBTB7A1   -- zinc finger and BTB domain containing 7A 90(n)
    94.31(a)
    788491  XM_001255535.1  XP_001255536.1 
    rat
    (Rattus norvegicus)
    Zbtb7a1   -- zinc finger and BTB domain containing 7a 84.61(n)
    90.05(a)
    117107  NM_054002.1  NP_446454.1 
    mouse
    (Mus musculus)
    Zbtb7a1, 5 105
    zinc finger and BTB domain containing 7a1, 5 85.82(n)1
    91.46(a)1
    169691  NM_010731.31  NP_034861.31 
     AA7964325  AF0868305  (see all 17)
    About this table        Species with no ortholog for ZBTB7A

    ENSEMBL Gene Tree for ZBTB7A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZBTB7A gene
    ZBTB242  ZBTB7C2  ZBTB7B2  ZBTB442  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/116 NCBI SNPs in ZBTB7A are shown (see all 116 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 36)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs104128251,2
    A,F,H3996962(+) CCTCAG/ACAGGG 1 -- ut31 ese34Minor allele frequency- A:0.02EU EA WA 416
    --
    rs72465841,2
    A,C4018092(+) CAAGTC/GGGGGG 1 -- ng310--------
    --
    rs134371,2
    C,F3996518(+) CATCCC/G/TGTAGA 1 -- ut31 ese33EA MN 1868
    --
    rs169896701,2
    F3997583(+) TTTTTC/TCTTCC 1 -- ut31 trp31Minor allele frequency- T:0.02MN 184
    rs104140351,2
    H3996434(+) GCCCCA/GGGGGA 1 -- ut31 ese3 trp31Minor allele frequency- G:0.00EU 118
    rs37459851,2
    H4005702(+) ggcggC/Tggccg 1 A/T mis1 ese31Minor allele frequency- T:0.00EU 120
    rs72510801,2
    H4005208(+) GCCCGC/TGACTC 1 S/S syn1 ese33Minor allele frequency- T:0.00EU EA 296
    rs8953311,2
    A,C,F,H4011222(-) ACCCTT/GGGAGG 1 -- int11Minor allele frequency- G:0.08EU 118
    --
    rs72456421,2
    A,C,F,H4004013(+) CCCAGA/GCTCAC 1 -- int14Minor allele frequency- G:0.26EU EA WA 412
    rs8953301,2
    A,F,H4011707(-) TGCCGG/CTCCCC 1 -- int17Minor allele frequency- C:0.26NA EA EU WA 664
    About this table

    HapMap Linkage Disequilibrium images for ZBTB7A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605878

    1 Novoseek disease relationship for ZBTB7A gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 18.24 2 9199312 (1), 15917220 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/26 PubMed articles for ZBTB7A gene (see all 26 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 51341 HGNC: 18078 AceView: ZBTB7 Ensembl:ENSG00000178951 euGenes: HUgn51341
    ECgene: ZBTB7A H-InvDB: ZBTB7A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ZBTB7A Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB7A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for ZBTB7A Antibodies for ZBTB7A
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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     Antibodies for ZBTB7A

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