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Aliases for ZBTB6 Gene

Aliases for ZBTB6 Gene

  • Zinc Finger And BTB Domain Containing 6 2 3 5
  • Zinc Finger Protein 482 2 3 4
  • Zinc Finger Protein With Interaction Domain 3 4
  • ZNF482 3 4
  • ZID 3 4
  • Zinc Finger And BTB Domain-Containing Protein 6 3

External Ids for ZBTB6 Gene

Previous HGNC Symbols for ZBTB6 Gene

  • ZNF482

Previous GeneCards Identifiers for ZBTB6 Gene

  • GC09M124710
  • GC09M125670
  • GC09M095286

Summaries for ZBTB6 Gene

GeneCards Summary for ZBTB6 Gene

ZBTB6 (Zinc Finger And BTB Domain Containing 6) is a Protein Coding gene. Diseases associated with ZBTB6 include Myasthenic Syndrome, Congenital, 5. An important paralog of this gene is ZBTB26.

UniProtKB/Swiss-Prot for ZBTB6 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB6 Gene

Genomics for ZBTB6 Gene

Regulatory Elements for ZBTB6 Gene

Enhancers for ZBTB6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G122939 1.1 ENCODE 22 -28.2 -28164 3.1 HDGF PKNOX1 FOXA2 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB6 ENSG00000261094 ZBTB26 RC3H2 RABGAP1 RNY1P15
GH09G122902 1.4 ENCODE dbSUPER 10.5 +9.1 9075 3.9 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZBTB26 ENSG00000261094 SNORD90 ZBTB6 RABGAP1 MIR600HG GC09P122904 PIR42233
GH09G123002 1 Ensembl ENCODE 12.1 -90.1 -90135 1.4 TAL1 BACH1 TCF12 ZNF316 ELK1 NCOR1 GATA2 NFE2 RELB MAFK ZBTB6 SNORD90 RABGAP1 GC09M123030 RNY1P15
GH09G122254 1 ENCODE 9.7 +658.5 658515 1.5 HDGF ATF1 ZNF493 ZFP64 YBX1 TCF12 ZNF766 GATA2 ZNF202 NCOA1 ZBTB26 ENSG00000261094 ZBTB6 MRRF LHX6
GH09G122991 0.8 ENCODE 11.9 -78.2 -78214 1.0 FEZF1 RAD21 RFX5 SCRT2 ZNF143 FOS MIXL1 ZNF654 ZNF362 CEBPB ZBTB6 ZBTB26 SNORD90 RABGAP1 GC09M123030 RNY1P15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB6 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241082 30 1800 PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 ZNF766

Genomic Location for ZBTB6 Gene

Chromosome:
9
Start:
122,908,056 bp from pter
End:
122,913,330 bp from pter
Size:
5,275 bases
Orientation:
Minus strand

Genomic View for ZBTB6 Gene

Genes around ZBTB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB6 Gene

Proteins for ZBTB6 Gene

  • Protein details for ZBTB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15916-ZBTB6_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 6
    Protein Accession:
    Q15916
    Secondary Accessions:
    • A8K8N6

    Protein attributes for ZBTB6 Gene

    Size:
    424 amino acids
    Molecular mass:
    48236 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB6 Gene

Post-translational modifications for ZBTB6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB6 Gene

Domains & Families for ZBTB6 Gene

Gene Families for ZBTB6 Gene

Protein Domains for ZBTB6 Gene

Suggested Antigen Peptide Sequences for ZBTB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB6: view

No data available for UniProtKB/Swiss-Prot for ZBTB6 Gene

Function for ZBTB6 Gene

Molecular function for ZBTB6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB6: view
genes like me logo Genes that share phenotypes with ZBTB6: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for ZBTB6 Gene

Selected GeneGlobe predicted Target genes for ZBTB6

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for ZBTB6 Gene

Localization for ZBTB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB6 gene
Compartment Confidence
nucleus 5
mitochondrion 4

Gene Ontology (GO) - Cellular Components for ZBTB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ZBTB6: view

Pathways & Interactions for ZBTB6 Gene

SuperPathways for ZBTB6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB6: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB6 Gene

Drugs & Compounds for ZBTB6 Gene

No Compound Related Data Available

Transcripts for ZBTB6 Gene

mRNA/cDNA for ZBTB6 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB6 Gene

Zinc finger and BTB domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB6 Gene

No ASD Table

Relevant External Links for ZBTB6 Gene

GeneLoc Exon Structure for
ZBTB6
ECgene alternative splicing isoforms for
ZBTB6

Expression for ZBTB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB6 Gene:

ZBTB6

SOURCE GeneReport for Unigene cluster for ZBTB6 Gene:

Hs.654596

mRNA Expression by UniProt/SwissProt for ZBTB6 Gene:

Q15916-ZBTB6_HUMAN
Tissue specificity: Widely expressed with highest levels in brain.
genes like me logo Genes that share expression patterns with ZBTB6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB6 Gene

Orthologs for ZBTB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB6 34 35
  • 99.92 (n)
cow
(Bos Taurus)
Mammalia ZBTB6 34 35
  • 92.37 (n)
dog
(Canis familiaris)
Mammalia ZBTB6 34 35
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Zbtb6 34 16 35
  • 89.91 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb6 34
  • 89.13 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB6 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB6 34 35
  • 72.82 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 33 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb6 34
  • 68.61 (n)
Str.19003 34
Species where no ortholog for ZBTB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZBTB6 Gene

ENSEMBL:
Gene Tree for ZBTB6 (if available)
TreeFam:
Gene Tree for ZBTB6 (if available)

Paralogs for ZBTB6 Gene

(3) SIMAP similar genes for ZBTB6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB6: view

Variants for ZBTB6 Gene

Sequence variations from dbSNP and Humsavar for ZBTB6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000074128 -- 122,908,471(+) TGCTC(A/C/G)CAAAA utr-variant-3-prime
rs1000862254 -- 122,914,532(+) ACCTG(-/TAA)TCCCT upstream-variant-2KB
rs1002385562 -- 122,910,118(+) AATCC(A/G)ATTGT utr-variant-3-prime
rs1002414909 -- 122,909,853(+) TGACT(A/G)CAAAG utr-variant-3-prime
rs1002810229 -- 122,909,670(+) CAGCT(A/G)GAATA utr-variant-3-prime

Variation tolerance for ZBTB6 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB6 Gene

Disorders for ZBTB6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBTB6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myasthenic syndrome, congenital, 5
  • congenital myasthenic syndrome 5
- elite association - COSMIC cancer census association via MalaCards
Search ZBTB6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZBTB6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB6
genes like me logo Genes that share disorders with ZBTB6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB6 Gene

Publications for ZBTB6 Gene

  1. The POZ domain: a conserved protein-protein interaction motif. (PMID: 7958847) Bardwell V.J. … Treisman R. (Genes Dev. 1994) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for ZBTB6 Gene

Sources for ZBTB6 Gene

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