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Aliases for ZBTB6 Gene

Aliases for ZBTB6 Gene

  • Zinc Finger And BTB Domain Containing 6 2 3 5
  • Zinc Finger Protein 482 2 3 4
  • Zinc Finger Protein With Interaction Domain 3 4
  • ZNF482 3 4
  • ZID 3 4
  • Zinc Finger And BTB Domain-Containing Protein 6 3

External Ids for ZBTB6 Gene

Previous HGNC Symbols for ZBTB6 Gene

  • ZNF482

Previous GeneCards Identifiers for ZBTB6 Gene

  • GC09M124710
  • GC09M125670
  • GC09M095286

Summaries for ZBTB6 Gene

GeneCards Summary for ZBTB6 Gene

ZBTB6 (Zinc Finger And BTB Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is ZBTB26.

UniProtKB/Swiss-Prot for ZBTB6 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB6 Gene

Genomics for ZBTB6 Gene

Regulatory Elements for ZBTB6 Gene

Enhancers for ZBTB6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F122254 0.5 ENCODE 36.9 +658.5 658515 1.5 HDGF ZNF493 ZFP64 GATA2 ZNF202 NCOA1 REST ZNF623 ZNF518A MBD2 ZBTB26 ENSG00000261094 ZBTB6 MRRF LHX6
GH09F122939 0.6 ENCODE 22 -28.2 -28164 3.1 HDGF PKNOX1 ATF1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ZBTB6 ENSG00000261094 ZBTB26 RC3H2 RABGAP1 RNY1P15
GH09F122947 0.8 Ensembl ENCODE 12.3 -34.5 -34471 1.2 JUND MTA2 MAFG CEBPB MLLT1 ZBTB6 SNORD90 ENSG00000233616 RNY1P15 GC09M123030
GH09F122953 1.1 Ensembl ENCODE 12.1 -41.0 -40971 1.0 JUND JUN STAT3 RCOR1 EP300 RFX5 ZBTB6 RABGAP1 RNY1P15 GC09M123030
GH09F123002 0.9 Ensembl ENCODE 12.1 -90.1 -90135 1.4 TAL1 BACH1 ZNF316 NCOR1 NFE2 MAFK NFE2L2 SMARCE1 MAFG SUPT20H ZBTB6 SNORD90 RABGAP1 GC09M123030 RNY1P15
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZBTB6 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404818 130 2400 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 CBX5 ZNF143

Genomic Location for ZBTB6 Gene

Chromosome:
9
Start:
122,908,056 bp from pter
End:
122,913,330 bp from pter
Size:
5,275 bases
Orientation:
Minus strand

Genomic View for ZBTB6 Gene

Genes around ZBTB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB6 Gene

Proteins for ZBTB6 Gene

  • Protein details for ZBTB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15916-ZBTB6_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 6
    Protein Accession:
    Q15916
    Secondary Accessions:
    • A8K8N6

    Protein attributes for ZBTB6 Gene

    Size:
    424 amino acids
    Molecular mass:
    48236 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB6 Gene

Post-translational modifications for ZBTB6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB6 Gene

Domains & Families for ZBTB6 Gene

Gene Families for ZBTB6 Gene

Suggested Antigen Peptide Sequences for ZBTB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15916

UniProtKB/Swiss-Prot:

ZBTB6_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB6: view

Function for ZBTB6 Gene

Molecular function for ZBTB6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB6: view
genes like me logo Genes that share phenotypes with ZBTB6: view

Animal Model Products

Transcription Factor Targets for ZBTB6 Gene

Selected GeneGlobe predicted Target genes for ZBTB6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for ZBTB6 Gene

Localization for ZBTB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB6 Gene COMPARTMENTS Subcellular localization image for ZBTB6 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZBTB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS --
genes like me logo Genes that share ontologies with ZBTB6: view

Pathways & Interactions for ZBTB6 Gene

SuperPathways for ZBTB6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB6: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB6 Gene

Transcripts for ZBTB6 Gene

mRNA/cDNA for ZBTB6 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB6 Gene

Zinc finger and BTB domain containing 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB6 Gene

No ASD Table

Relevant External Links for ZBTB6 Gene

GeneLoc Exon Structure for
ZBTB6
ECgene alternative splicing isoforms for
ZBTB6

Expression for ZBTB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB6 Gene:

ZBTB6

SOURCE GeneReport for Unigene cluster for ZBTB6 Gene:

Hs.654596

mRNA Expression by UniProt/SwissProt for ZBTB6 Gene:

Q15916-ZBTB6_HUMAN
Tissue specificity: Widely expressed with highest levels in brain.
genes like me logo Genes that share expression patterns with ZBTB6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZBTB6 Gene

Orthologs for ZBTB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB6 34 35
  • 99.92 (n)
cow
(Bos Taurus)
Mammalia ZBTB6 34 35
  • 92.37 (n)
dog
(Canis familiaris)
Mammalia ZBTB6 34 35
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Zbtb6 34 16 35
  • 89.91 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb6 34
  • 89.13 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB6 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB6 34 35
  • 72.82 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 33 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb6 34
  • 68.61 (n)
Str.19003 34
Species where no ortholog for ZBTB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZBTB6 Gene

ENSEMBL:
Gene Tree for ZBTB6 (if available)
TreeFam:
Gene Tree for ZBTB6 (if available)

Paralogs for ZBTB6 Gene

(3) SIMAP similar genes for ZBTB6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB6: view

Variants for ZBTB6 Gene

Sequence variations from dbSNP and Humsavar for ZBTB6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10985820 -- 122,909,691(+) ATTCA(A/G)AATTT utr-variant-3-prime
rs10985821 -- 122,914,736(+) ACTCT(G/T)TGGTC upstream-variant-2KB
rs111602210 -- 122,909,813(+) GTGAC(A/G)GAGAA utr-variant-3-prime
rs112217898 -- 122,911,458(+) GTAGA(C/G)AGCTC reference, synonymous-codon
rs112321360 -- 122,915,041(+) TTTTT(A/T)TTTTG upstream-variant-2KB

Variation tolerance for ZBTB6 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB6 Gene

Disorders for ZBTB6 Gene

Relevant External Links for ZBTB6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB6

No disorders were found for ZBTB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB6 Gene

Publications for ZBTB6 Gene

  1. The POZ domain: a conserved protein-protein interaction motif. (PMID: 7958847) Bardwell V.J. … Treisman R. (Genes Dev. 1994) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for ZBTB6 Gene

Sources for ZBTB6 Gene

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