ZBTB6 Gene
protein-coding GIFtS: 46
GCID: GC09M125670
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|
zinc finger and BTB domain containing 6(Previous name: zinc finger protein 482 )
(Previous symbol: ZNF482)
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Aliases
for ZBTB6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 61 2 | | Zinc Finger Protein 4821 2 3 | | ZID1 2 3 | | ZNF4821 2 3 | | Zinc Finger Protein With Interaction Domain2 3 | | Zinc Finger And BTB Domain-Containing Protein 62 |
Export aliases for ZBTB6 gene to outside databasesPrevious GC identifers: GC09M124710 GC09M095286 |
Summaries
for ZBTB6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBTB6_HUMAN, Q15916Function: May be involved in transcriptional regulation
|
Genomic Views
for ZBTB6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB6 gene promoter:
AhR CUTL1 NF-AT NF-AT4 NF-AT2 Ik-2 POU2F1b POU2F1a NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q33.2 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q33.1-q33.3ZBTB6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M125670: view genomic region
(about GC identifiers)
Start:
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125,670,335 bp from pter |
End:
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125,675,609 bp from pter |
Size:
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5,275 bases |
Orientation:
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minus strand |
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Proteins
for ZBTB6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBTB6_HUMAN, Q15916 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 6 Size: 424 amino acids; 48236 Da
Subcellular location: Nucleus
Secondary accessions: A8K8N6Explore the universe of human proteins at neXtProt for ZBTB6: NX_Q15916
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15916
ZBTB6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006617.1
ENSEMBL proteins: ENSP00000362763
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZBTB6 for ontologies About GeneDecksing
ZBTB6 Antibody Products:
Assay Products for ZBTB6: |
Protein
Domains /
Families
for ZBTB6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB6 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q15916ProtoNet protein and cluster: Q15916 2 Blocks protein families: IPB000210 BTB/POZ domain IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZBTB6_HUMAN, Q15916Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 4 C2H2-type zinc fingers |
Function
for ZBTB6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBTB6_HUMAN, Q15916Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZBTB6 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZBTB6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB6
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for ZBTB6 (Q159162, 3 ENSP000003627634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB6 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB6
Search CenterWatch for drugs/clinical trials and news about ZBTB6
|
Transcripts
for ZBTB6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB6 gene: NM_006626.5 Unigene Cluster for ZBTB6: Zinc finger and BTB domain containing 6 Hs.654596 [show with all ESTs]Unigene Representative Sequence: BC0372821 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000373659(uc004bnh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB6 (NM_006626) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB6 |
Additional cDNA sequence: AK098650.1 AK292401.1 BC037282.2 X82018.1 2 DOTS entries: DT.407524 DT.100747947 24/43 AceView cDNA sequences (see all 43): AL556347 AA397823 AA306080 CK906108 AI521489 BM127191 AU146846 BC037282 NM_006626 AK098650 CR607983 AU280590 AU128455 CK906109 BU686074 BV185794 X82018 AL708874 AU120905 AL556501 BP352238 AL578745 BQ021601 BM908909
GeneLoc Exon Structure
|
Expression
for ZBTB6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTACATAAG
About this image
See ZBTB6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB6
SOURCE GeneReport for Unigene cluster: Hs.654596
UniProtKB/Swiss-Prot: ZBTB6_HUMAN, Q15916Tissue specificity: Widely expressed with highest levels in brain
SABiosciences Custom PCR Arrays for ZBTB6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB6 |
Orthologs
for ZBTB6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB6 gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZBTB61 |
zinc finger and BTB domain containing 6 |
72.82(n)
76.7(a) |
|
417108 XM_415393.3 XP_415393.1 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.190032 |
Transcribed sequence with moderate similarity to protein more |
76.4(n) |
|
141990985 |
ENSEMBL Gene Tree for ZBTB6 (if available)
TreeFam Gene Tree for ZBTB6 (if available) |
Paralogs
for ZBTB6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB6 gene
- ZBTB222 ZBTB342 NACC12 ZBTB452 ZBTB92 NACC22 ZBTB432 ZBTB262
- ZBTB122 ZBTB372 ZBTB202
4 SIMAP similar genes for ZBTB6 using alignment to 1 protein entry: ZBTB6_HUMAN:ZBTB26 ZNF323 ZBTB12 ZBTB37
ZBTB6 for paralogs About GeneDecksing
|
Genomic Variants
for ZBTB6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB6 (125670335 - 125675609 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBTB6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB6 |
|
Disorders
/ Diseases
for ZBTB6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZBTB6 for disorders About MalaCards
ZBTB6 for disorders About GeneDecksing
OMIM gene information: 605976
OMIM disorders: --
Export disorders for ZBTB6 gene to outside databases
|
Publications
for ZBTB6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB6 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZBTB6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The POZ domain: a conserved protein-protein interaction motif. (PubMed id 7958847)1, 2, 3 Bardwell V.J. and Treisman R. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- NAC1, a POZ/BTB protein that functions as a corepressor. (PubMed id 19121354)1 Korutla L....Mackler S.A. (2009)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- KRAB-zinc finger proteins and KAP1 can mediate long-r ange transcriptional repression through heterochromatin spreading. (PubMed id 20221260)9 Groner A.C....Trono D. (2010)
- Identification of nuclear dicing bodies containing pr oteins for microRNA biogenesis in living Arabidopsis plants. (PubMed id 17442570)9 Fang Y. and Spector D.L. (2007)
- Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains. (PubMed id 11054286)9 Dreier B....Barbas C.F. (2000)
|
External Searches for ZBTB6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB6 gene:
Search GeneIP for patents involving ZBTB6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for ZBTB6 | | OriGene Custom Protein Services for ZBTB6 | | | OriGene Custom Immunoassay Development | | |
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| |
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| |  |  |  |  | | | | |
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 | | | ZBTB6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB6 |
|  |  |  | | | | ThermoFisher Antibodies for ZBTB6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB6 |
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