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Aliases for ZBTB5 Gene

Aliases for ZBTB5 Gene

  • Zinc Finger And BTB Domain Containing 5 2 3 5
  • KIAA0354 4

External Ids for ZBTB5 Gene

Previous GeneCards Identifiers for ZBTB5 Gene

  • GC09M037429
  • GC09M037430

Summaries for ZBTB5 Gene

GeneCards Summary for ZBTB5 Gene

ZBTB5 (Zinc Finger And BTB Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is ZBTB18.

UniProtKB/Swiss-Prot for ZBTB5 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB5 Gene

Genomics for ZBTB5 Gene

Regulatory Elements for ZBTB5 Gene

Enhancers for ZBTB5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G037463 1.4 ENCODE dbSUPER 38.4 -0.9 -855 5.8 HDGF FOXA2 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 EXOSC3 ZBTB5 RPL21P83 TRMT10B GRHPR TMX2P1 KCTD9P3
GH09G038035 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 16.6 -572.9 -572935 6.4 HDGF ATF1 PKNOX1 CREB3L1 SIN3A TCF12 GTF3C2 ZNF766 GATA2 FOS ZBTB5 TMX2P1 EXOSC3 RPL21P83 SHB GC09P038069 GC09M038063
GH09G037799 1.2 ENCODE 30 -335.7 -335719 2.9 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 EXOSC3 TRMT10B ZBTB5 SLC25A51 RPL21P83 DCAF10
GH09G037485 1.3 ENCODE dbSUPER 26.9 -21.4 -21391 3.5 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 RPL21P83 POLR1E ZBTB5 EXOSC3 FBXO10 ENSG00000234160 ENSG00000256966 TOMM5 FRMPD1 GRHPR
GH09G037470 1.4 Ensembl ENCODE dbSUPER 21.5 -6.8 -6775 3.6 FOXA2 SIN3A GTF3C2 GATA2 FOS ZNF623 MAFF SMARCA4 GLIS1 STAT3 ZBTB5 EXOSC3 ENSG00000234160 RPL21P83 TMX2P1 KCTD9P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB5 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234866 -190 3201 HDGF FOXA2 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1

Genomic Location for ZBTB5 Gene

Chromosome:
9
Start:
37,438,102 bp from pter
End:
37,465,410 bp from pter
Size:
27,309 bases
Orientation:
Minus strand

Genomic View for ZBTB5 Gene

Genes around ZBTB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB5 Gene

Proteins for ZBTB5 Gene

  • Protein details for ZBTB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15062-ZBTB5_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 5
    Protein Accession:
    O15062

    Protein attributes for ZBTB5 Gene

    Size:
    677 amino acids
    Molecular mass:
    74278 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20811.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZBTB5 Gene

Post-translational modifications for ZBTB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB5 Gene

Domains & Families for ZBTB5 Gene

Gene Families for ZBTB5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB5: view

No data available for UniProtKB/Swiss-Prot for ZBTB5 Gene

Function for ZBTB5 Gene

Molecular function for ZBTB5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB5: view
genes like me logo Genes that share phenotypes with ZBTB5: view

Animal Model Products

CRISPR Products

miRNA for ZBTB5 Gene

miRTarBase miRNAs that target ZBTB5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB5 Gene

Localization for ZBTB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB5 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ZBTB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19491398
genes like me logo Genes that share ontologies with ZBTB5: view

Pathways & Interactions for ZBTB5 Gene

SuperPathways for ZBTB5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB5: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB5 Gene

Drugs & Compounds for ZBTB5 Gene

No Compound Related Data Available

Transcripts for ZBTB5 Gene

mRNA/cDNA for ZBTB5 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(183) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB5 Gene

Zinc finger and BTB domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB5 Gene

No ASD Table

Relevant External Links for ZBTB5 Gene

GeneLoc Exon Structure for
ZBTB5
ECgene alternative splicing isoforms for
ZBTB5

Expression for ZBTB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB5 Gene:

ZBTB5

SOURCE GeneReport for Unigene cluster for ZBTB5 Gene:

Hs.161276

Evidence on tissue expression from TISSUES for ZBTB5 Gene

  • Nervous system(4.7)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with ZBTB5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB5 Gene

Orthologs for ZBTB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB5 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia ZBTB5 34 35
  • 92.22 (n)
cow
(Bos Taurus)
Mammalia ZBTB5 34 35
  • 89.69 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb5 34
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Zbtb5 34 16 35
  • 88.81 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB5 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB5 34 35
  • 79.69 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB5 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb5 34
  • 71.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4309 34
zebrafish
(Danio rerio)
Actinopterygii LOC797291 34
  • 57.96 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for ZBTB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB5 Gene

ENSEMBL:
Gene Tree for ZBTB5 (if available)
TreeFam:
Gene Tree for ZBTB5 (if available)

Paralogs for ZBTB5 Gene

Pseudogenes.org Pseudogenes for ZBTB5 Gene

genes like me logo Genes that share paralogs with ZBTB5: view

Variants for ZBTB5 Gene

Sequence variations from dbSNP and Humsavar for ZBTB5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000117495 -- 37,465,104(+) CGGGG(A/G)CACCA intron-variant, upstream-variant-2KB
rs1000183440 -- 37,439,548(+) TGCTA(C/T)ATGGG utr-variant-3-prime
rs1000253941 -- 37,447,482(+) TTTTT(A/G)AGACA intron-variant
rs1000295192 -- 37,454,352(+) CTGCC(C/T)GTCTG intron-variant
rs1000370890 -- 37,447,013(+) ACTGC(C/T)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB5 Gene

Variant ID Type Subtype PubMed ID
esv3544827 CNV deletion 23714750
esv3620407 CNV loss 21293372
nsv1125318 OTHER inversion 24896259

Variation tolerance for ZBTB5 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB5 Gene

Disorders for ZBTB5 Gene

Relevant External Links for ZBTB5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB5

No disorders were found for ZBTB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB5 Gene

Publications for ZBTB5 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64

Products for ZBTB5 Gene

Sources for ZBTB5 Gene

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