Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZBTB5 Gene

Aliases for ZBTB5 Gene

  • Zinc Finger And BTB Domain Containing 5 2 3 5
  • KIAA0354 4

External Ids for ZBTB5 Gene

Previous GeneCards Identifiers for ZBTB5 Gene

  • GC09M037429
  • GC09M037430

Summaries for ZBTB5 Gene

GeneCards Summary for ZBTB5 Gene

ZBTB5 (Zinc Finger And BTB Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for ZBTB5 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB5 Gene

Genomics for ZBTB5 Gene

Regulatory Elements for ZBTB5 Gene

Promoters for ZBTB5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB5 Gene

37,438,102 bp from pter
37,465,410 bp from pter
27,309 bases
Minus strand

Genomic View for ZBTB5 Gene

Genes around ZBTB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB5 Gene

Proteins for ZBTB5 Gene

  • Protein details for ZBTB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 5
    Protein Accession:

    Protein attributes for ZBTB5 Gene

    677 amino acids
    Molecular mass:
    74278 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA20811.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZBTB5 Gene

Proteomics data for ZBTB5 Gene at MOPED

Post-translational modifications for ZBTB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB5 Gene

Domains & Families for ZBTB5 Gene

Gene Families for ZBTB5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 2 C2H2-type zinc fingers.
  • Contains 1 BTB (POZ) domain.
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB5: view

Function for ZBTB5 Gene

Molecular function for ZBTB5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZBTB5: view

Animal Model Products

miRNA for ZBTB5 Gene

miRTarBase miRNAs that target ZBTB5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB5 Gene

Localization for ZBTB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB5 Gene

Subcellular locations from

Jensen Localization Image for ZBTB5 Gene COMPARTMENTS Subcellular localization image for ZBTB5 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for ZBTB5 Gene

Pathways & Interactions for ZBTB5 Gene

SuperPathways for ZBTB5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB5 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZBTB5 Gene

Drugs & Compounds for ZBTB5 Gene

No Compound Related Data Available

Transcripts for ZBTB5 Gene

mRNA/cDNA for ZBTB5 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(183) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB5 Gene

Zinc finger and BTB domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB5 Gene

No ASD Table

Relevant External Links for ZBTB5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB5 Gene

mRNA expression in normal human tissues for ZBTB5 Gene

SOURCE GeneReport for Unigene cluster for ZBTB5 Gene Hs.161276

genes like me logo Genes that share expression patterns with ZBTB5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZBTB5 Gene

Orthologs for ZBTB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZBTB5 35
  • 89.69 (n)
  • 95.41 (a)
ZBTB5 36
  • 95 (a)
(Canis familiaris)
Mammalia ZBTB5 35
  • 92.22 (n)
  • 97.05 (a)
ZBTB5 36
  • 97 (a)
(Mus musculus)
Mammalia Zbtb5 35
  • 88.81 (n)
  • 94.03 (a)
Zbtb5 16
Zbtb5 36
  • 94 (a)
(Pan troglodytes)
Mammalia ZBTB5 35
  • 99.66 (n)
  • 99.7 (a)
ZBTB5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zbtb5 35
  • 89.35 (n)
  • 94.03 (a)
(Monodelphis domestica)
Mammalia ZBTB5 36
  • 88 (a)
(Gallus gallus)
Aves ZBTB5 35
  • 79.69 (n)
  • 86.92 (a)
ZBTB5 36
  • 87 (a)
(Anolis carolinensis)
Reptilia ZBTB5 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb5 35
  • 71.78 (n)
  • 76.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4309 35
(Danio rerio)
Actinopterygii LOC797291 35
  • 57.96 (n)
  • 56.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for ZBTB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB5 Gene

Gene Tree for ZBTB5 (if available)
Gene Tree for ZBTB5 (if available)

Paralogs for ZBTB5 Gene Pseudogenes for ZBTB5 Gene

genes like me logo Genes that share paralogs with ZBTB5: view

Variants for ZBTB5 Gene

Sequence variations from dbSNP and Humsavar for ZBTB5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs17502738 - 37,441,653(+) CCTGA(C/T)CAAAA reference, missense
rs188685 -- 37,444,407(+) gttgg(C/T)caggc intron-variant
rs309440 -- 37,459,999(+) gccac(C/T)gcgcc intron-variant
rs309441 -- 37,459,856(+) cgggc(A/C/G)cccgc intron-variant
rs309442 -- 37,459,596(+) ttacc(C/T)aggct intron-variant

Variation tolerance for ZBTB5 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB5 Gene

Disorders for ZBTB5 Gene

Relevant External Links for ZBTB5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZBTB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB5 Gene

Publications for ZBTB5 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for ZBTB5 Gene

Sources for ZBTB5 Gene

Back to Top