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ZBTB5 Gene

protein-coding GIFtS: 49

GC09M037431

zinc finger and BTB domain containing 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA0354 ^¹, ³
OTTHUMP00000021384 ^²
OTTHUMP00000046108 ^²

Descriptions
zinc finger and BTB domain containing 5 ^²

External Ids
HGNC: 23836¹
Entrez Gene: 9925²
UniProtKB: O15062³
Ensembl: ENSG00000168795⁷

Search outside databases for aliases for ZBTB5 gene

Previous GC identifers: GC09M037429 GC09M037430

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBTB5_HUMAN, O15062

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZBTB5 gene

Entrez Gene cytogenetic band: 9p13.2 Ensembl cytogenetic band: 9p13.2 HGNC cytogenetic band: 9p13.1

ZBTB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M037431: (about GC identifiers)

Start:	37,428,111 bp from pter
End:	37,455,396 bp from pter
Size:	27,286 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBTB5_HUMAN, O15062 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 5

Size: 677 amino acids; 74278 Da

Subcellular location: Nucleus (Potential)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055687.1

ENSEMBL proteins:

ENSP00000307604

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: ZBTB5

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

About this table

Antibodies for ZBTB5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZBTB5

Assays for ZBTB5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15062

ProtoNet protein and cluster: O15062

2 Blocks protein families:

IPB000210 BTB/POZ domain

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZBTB5_HUMAN, O15062

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 2 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014872

Applied Biosystems Silencer® siRNAs for ZBTB5

Sigma-Aldrich siRNA and siRNA Panels for ZBTB5

Sigma-Aldrich shRNA for ZBTB5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZBTB5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014872
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014872
untagged cDNA clone in CMV expression vector: NM_014872

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014872

UniProtKB/Swiss-Prot: ZBTB5_HUMAN, O15062

Function: May be involved in transcriptional regulation

1 MGI phenotypic allele for Zbtb5 (no phenotypes)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Interacting proteins for ZBTB5 (O15062²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
ST3GAL3 Q11203² MINT-64080
-- Q96HA0² MINT-67648
-- Q8R4T5² MINT-1790502
About this table
2 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006350 transcription IEA --
GO:0006355 regulation of transcription, DNA-dependent IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014872

Sigma-Aldrich siRNA and siRNA Panels for ZBTB5

Sigma-Aldrich shRNA for ZBTB5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014872

REFSEQ mRNAs for ZBTB5 gene:

NM_014872.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014872

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014872
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014872
                                 untagged cDNA clone in CMV expression vector: NM_014872

Additional cDNA sequence:

AB002352.1 AK292404.1 BC010007.2 CR603598.1 CR626350.1

7 DOTS entries:

DT.100763774 DT.454470 DT.100763775 DT.75123078 DT.100721272 DT.100763771 DT.121203440

24/183 AceView cDNA sequences (see all 183 ):

N90937 AA909142 BI771844 BM693184 BU633222 AI143474 CR603598 W30814

AA189147 AW389756 BM893720 BM479535 BM766292 BG830994 AI784407 NM_014872

AI434925 AA806810 CR626350 BQ045093 AL532580 CA439277 BM548889 CF618975

highest scoring ESTs for ZBTB5:

AB002352 AL708556 BC010007 BF568092 BG830994 BG831418 BI192745 BI829117 BM479535 BU182053

Unigene Cluster for ZBTB5:

Zinc finger and BTB domain containing 5

Hs.161276 [show with all ESTs]

Unigene Representative Sequence: NM_014872

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000307750

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB5

¹ / ² / ³

3 probe-sets matching ZBTB5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34395_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	AB002352	1.00	1.00	1.00	1
203026_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014872	0.60	1.00	0.82	1
203026_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCAGTGGTGC

SOURCE GeneReport for Unigene cluster: Hs.161276
Expression variation in blood from EXPOLDB for ZBTB5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBTB5 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBTB5¹	--	zinc finger and BTB domain containing 5	92.32(n) 97.05(a)	481612 XM_538734.2 XP_538734.2
cow (Bos taurus)	ZBTB5¹	--	zinc finger and BTB domain containing 5	89.64(n) 95.41(a)	518910 XM_001250023.1 XP_001250024.1
rat (Rattus norvegicus)	Zbtb5¹	--	zinc finger and BTB domain containing 5	89.25(n) 94.03(a)	298084 XM_233005.3 XP_233005.3
mouse (Mus musculus)	Zbtb5^{1, 5}	4⁵	zinc finger and BTB domain containing 5^{1, 5}	88.71(n)¹ 94.03(a)¹	230119¹ NM_173399.2¹ NP_775575.2¹ AA161998⁵ AA667684⁵ (see all 20)
chicken (Gallus gallus)	ZBTB5¹	--	zinc finger and BTB domain containing 5	79.59(n) 86.92(a)	431260 XM_428814.2 XP_428814.2

About this table Species with no ortholog for ZBTB5

ENSEMBL Gene Tree for ZBTB5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB5 gene

HIC1² HIC2² MYNN²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/122 NCBI SNPs in ZBTB5 are shown (see all 122 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7031029^1,2	A,C,F,H	37427697(+)	`TTTTTT/AAATCA`	1	--	ng5¹		4		EU EA WA	410
	rs7022431^1,2	A,C,F,H	37429045(+)	`TTATGA/CATGAT`	1	--	ut3¹ ese³		11		EU EA WA NA	978
	rs2840246^1,2	A,C,F,H	37428526(+)	`GTCCAC/TTTATG`	1	--	ut3¹		5		MN EU EA WA	600
	rs7039333^1,2	C,F,H	37429351(+)	`AATATT/GTACCC`	1	--	ut3¹		11		NA EU EA WA	978
	rs17502738^1,2	C,F,H	37431650(+)	`CCTGAT/CCAAAA`	1	G/D	mis¹ ese³		12		NA EU EA WA	1056
--	rs10758430^1,2	A,C	37456599(+)	`TGGGGC/GTAAGG`	1	--	ng3¹		0	--	--	--	--
	rs12348205^1,2	H	37428070(+)	`TCAACC/TTTAAT`	1	--	ng5¹		4		EU EA WA	404
--	rs1854161^1,2	C	37456882(-)	`agcggC/Tacgat`	1	--	ng3¹		0	--	--	--	--
--	rs2308190^1,2	F	37429791(+)	`AACAAACAA/- TACCT`	1	--	ut3¹		4		EU NA EA	342
	rs13300415^1,2	H	37428647(+)	`AGGGCC/TTCTCA`	1	--	ut3¹ ese³		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for ZBTB5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for ZBTB5 gene:

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{2, 3, 4} Nagase T....Ohara O. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9925	HGNC: 23836	AceView: ZBTB5	Ensembl:ENSG00000168795	euGenes: HUgn9925
ECgene: ZBTB5	H-InvDB: ZBTB5

(According to HUGE)
About This Section

HUGE: KIAA0354

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBTB5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB5		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBTB5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ZBTB5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ZBTB5

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ZBTB5 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for ZBTB5

Summaries
for ZBTB5

Genomic Location
for ZBTB5

Proteins
for ZBTB5

Protein Domains/
Families
for ZBTB5

Gene Function
for ZBTB5

Pathways & Interactions
for ZBTB5

Drugs & Compounds
for ZBTB5

Transcripts
for ZBTB5

Expression
for ZBTB5

Orthologs
for ZBTB5

Paralogs
for ZBTB5

SNPs/Variants
for ZBTB5

Disorders & Mutations
for ZBTB5

Medical News
for ZBTB5

Publications
for ZBTB5

Search for ZBTB5

Genome Databases showing ZBTB5

Other Databases showing ZBTB5

Specialized Databases showing ZBTB5

Licensable Technologies
for ZBTB5

Services
for ZBTB5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB5 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor ZBTB5

Summariesfor ZBTB5

Genomic Locationfor ZBTB5

Proteinsfor ZBTB5

Protein Domains/Familiesfor ZBTB5

Gene Functionfor ZBTB5

Pathways & Interactionsfor ZBTB5

Drugs & Compoundsfor ZBTB5

Transcriptsfor ZBTB5

Expression for ZBTB5

Orthologsfor ZBTB5

Paralogsfor ZBTB5

SNPs/Variantsfor ZBTB5

Disorders & Mutationsfor ZBTB5

Medical Newsfor ZBTB5

Publicationsfor ZBTB5

Search for ZBTB5

Genome Databases showing ZBTB5

Other Databases showing ZBTB5

Specialized Databases showing ZBTB5

Licensable Technologiesfor ZBTB5

Servicesfor ZBTB5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB5

Summaries
for ZBTB5

Genomic Location
for ZBTB5

Proteins
for ZBTB5

Protein Domains/
Families
for ZBTB5

Gene Function
for ZBTB5

Pathways & Interactions
for ZBTB5

Drugs & Compounds
for ZBTB5

Transcripts
for ZBTB5

Expression
for ZBTB5

Orthologs
for ZBTB5

Paralogs
for ZBTB5

SNPs/Variants
for ZBTB5

Disorders & Mutations
for ZBTB5

Medical News
for ZBTB5

Publications
for ZBTB5

Licensable Technologies
for ZBTB5

Services
for ZBTB5