Aliases for ZBTB49 Gene
External Ids for ZBTB49 Gene
Previous HGNC Symbols for ZBTB49 Gene
GeneCards Summary for ZBTB49 Gene
ZBTB49 (Zinc Finger And BTB Domain Containing 49) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription factor binding. An important paralog of this gene is ZBTB17.
UniProtKB/Swiss-Prot for ZBTB49 Gene
Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.
Isoform 1: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).
Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.