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Aliases for ZBTB49 Gene

Aliases for ZBTB49 Gene

  • Zinc Finger And BTB Domain Containing 49 2 3
  • Zinc Finger Protein 509 2 3 4
  • ZNF509 3 4
  • Zinc Finger And BTB Domain-Containing Protein 49 3

External Ids for ZBTB49 Gene

Previous Symbols for ZBTB49 Gene

  • ZNF509

Summaries for ZBTB49 Gene

GeneCards Summary for ZBTB49 Gene

ZBTB49 (Zinc Finger And BTB Domain Containing 49) is a Protein Coding gene. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for ZBTB49 Gene

  • Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.

  • Isoform 1: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).

  • Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB49 Gene

Genomics for ZBTB49 Gene

Genomic Location for ZBTB49 Gene

Start:
4,290,197 bp from pter
End:
4,321,786 bp from pter
Size:
31,590 bases
Orientation:
Plus strand

Genomic View for ZBTB49 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB49 Gene

No data available for Regulatory Elements for ZBTB49 Gene

Proteins for ZBTB49 Gene

  • Protein details for ZBTB49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSB9-ZBT49_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 49
    Protein Accession:
    Q6ZSB9
    Secondary Accessions:
    • A8K936
    • Q32ML0
    • Q59FJ4
    • Q5EBN0
    • Q8TB80

    Protein attributes for ZBTB49 Gene

    Size:
    765 amino acids
    Molecular mass:
    85061 Da
    Quaternary structure:
    • Isoform 1 interacts with EP300 and KAT5/Tip60. The interaction with EP300 is direct and leads to synergistic induction of CDKN1A. On the CDKN1A promoter, forms a complex with ZBTB17/Miz-1; this interaction leads to additive CDKN1A transactivation. Isoform 3 also interacts with ZBTB17; this interaction may block ZBTB17 repressor activity.
    SequenceCaution:
    • Sequence=AAH16477.1; Type=Erroneous termination; Positions=372; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBTB49 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB49 Gene

Proteomics data for ZBTB49 Gene at MOPED

Post-translational modifications for ZBTB49 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB49 Gene

No data available for DME Specific Peptides for ZBTB49 Gene

Domains for ZBTB49 Gene

Gene Families for ZBTB49 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

Suggested Antigen Peptide Sequences for ZBTB49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZSB9

UniProtKB/Swiss-Prot:

ZBT49_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q6ZSB9
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q6ZSB9
Similarity:
  • Contains 7 C2H2-type zinc fingers.:
    • Q6ZSB9
genes like me logo Genes that share domains with ZBTB49: view

Function for ZBTB49 Gene

Molecular function for ZBTB49 Gene

UniProtKB/Swiss-Prot Function: Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.
UniProtKB/Swiss-Prot Function: Isoform 1: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).
UniProtKB/Swiss-Prot Function: Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.
UniProtKB/Swiss-Prot Induction: Induced by the DNA-damaging agent etoposide. This induction is mediated by TP53 at the transcriptional level.

Gene Ontology (GO) - Molecular Function for ZBTB49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001223 transcription coactivator binding IPI 25245946
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0005515 protein binding --
GO:0008134 transcription factor binding IPI 25245946
genes like me logo Genes that share ontologies with ZBTB49: view

Phenotypes for ZBTB49 Gene

genes like me logo Genes that share phenotypes with ZBTB49: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZBTB49 Gene

Localization for ZBTB49 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB49 Gene

Isoform 1: Cytoplasm. Nucleus. Note=Predominantly located in the nucleus. {ECO:0000269 PubMed:25245946}.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB49 Gene COMPARTMENTS Subcellular localization image for ZBTB49 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ZBTB49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25245946
GO:0005737 cytoplasm IDA 25245946
genes like me logo Genes that share ontologies with ZBTB49: view

Pathways for ZBTB49 Gene

SuperPathways for ZBTB49 Gene

No Data Available

Interacting Proteins for ZBTB49 Gene

Gene Ontology (GO) - Biological Process for ZBTB49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007050 cell cycle arrest IDA 25245946
GO:0008285 negative regulation of cell proliferation IDA 25245946
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 25245946
genes like me logo Genes that share ontologies with ZBTB49: view

No data available for Pathways by source for ZBTB49 Gene

Transcripts for ZBTB49 Gene

Unigene Clusters for ZBTB49 Gene

Zinc finger and BTB domain containing 49:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB49 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:
SP2: - -
SP3: - -
SP4: - - -
SP5: - - - -

Relevant External Links for ZBTB49 Gene

GeneLoc Exon Structure for
ZBTB49
ECgene alternative splicing isoforms for
ZBTB49

Expression for ZBTB49 Gene

mRNA expression in normal human tissues for ZBTB49 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZBTB49 Gene

SOURCE GeneReport for Unigene cluster for ZBTB49 Gene Hs.419997

mRNA Expression by UniProt/SwissProt for ZBTB49 Gene

Q6ZSB9-ZBT49_HUMAN
Tissue specificity: Highly expressed in normal epidermis and in other epithelial tissues, including in colon and lung. Tends to be down-regulated in colon, lung and skin cancer tissues.
genes like me logo Genes that share expressions with ZBTB49: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZBTB49 Gene

Orthologs for ZBTB49 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB49 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB49 35
  • 99.61 (n)
  • 99.74 (a)
ZBTB49 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB49 35
  • 80.18 (n)
  • 81.32 (a)
ZBTB49 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB49 35
  • 82.24 (n)
  • 81.68 (a)
ZBTB49 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb49 35
  • 77.17 (n)
  • 75.36 (a)
Zbtb49 16
Zbtb49 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB49 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB49 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb49 35
  • 70.13 (n)
  • 63.77 (a)
chicken
(Gallus gallus)
Aves ZBTB49 35
  • 72.18 (n)
  • 73.49 (a)
ZBTB49 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB49 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24174 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10598 35
zbtb49 35
  • 59.06 (n)
  • 52.38 (a)
zebrafish
(Danio rerio)
Actinopterygii zbtb49 35
  • 59.23 (n)
  • 57.62 (a)
ZBTB49 36
  • 72 (a)
OneToOne
Species with no ortholog for ZBTB49:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB49 Gene

ENSEMBL:
Gene Tree for ZBTB49 (if available)
TreeFam:
Gene Tree for ZBTB49 (if available)

Paralogs for ZBTB49 Gene

Selected SIMAP similar genes for ZBTB49 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZBTB49 Gene

genes like me logo Genes that share paralogs with ZBTB49: view

Variants for ZBTB49 Gene

Sequence variations from dbSNP and Humsavar for ZBTB49 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3985 -- 4,299,694(-) GCTCA(A/G)TACAG intron-variant
rs748107 -- 4,317,607(-) TTAGT(C/G)CAAGA intron-variant
rs749443 -- 4,316,970(+) GAGGC(C/G)GAGGC intron-variant
rs768133 -- 4,307,254(-) CTGGG(C/T)GTTCT intron-variant
rs768134 -- 4,306,924(-) CTACC(A/T)TGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB49 Gene

Variant ID Type Subtype PubMed ID
dgv1566e1 CNV Complex 17122850
nsv10437 CNV Gain 18304495
nsv4205 CNV Insertion 18451855
esv34196 OTHER Inversion 12058347

Relevant External Links for ZBTB49 Gene

HapMap Linkage Disequilibrium report
ZBTB49

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB49 Gene

Disorders for ZBTB49 Gene

No disorders were found for ZBTB49 Gene.

No data available for UniProtKB/Swiss-Prot for ZBTB49 Gene

Publications for ZBTB49 Gene

  1. Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress. (PMID: 25245946) Jeon B.N. … Hur M.W. (Nucleic Acids Res. 2014) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for ZBTB49 Gene

Sources for ZBTB49 Gene

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