ZBTB49 Gene
protein-coding GIFtS: 44
GCID: GC04P004291
|
|
zinc finger and BTB domain containing 49(Previous name: zinc finger protein 509 )
(Previous symbol: ZNF509)
| |
Aliases
for ZBTB49 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 491 2 | | Zinc Finger Protein 5091 2 3 | | ZNF5091 2 3 | | FLJ385591 | | Zinc Finger And BTB Domain-Containing Protein 492 |
Export aliases for ZBTB49 gene to outside databases |
Summaries
for ZBTB49 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT49_HUMAN, Q6ZSB9Function: May be involved in transcriptional regulation
|
Genomic Views
for ZBTB49 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006051.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZBTB49
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB49
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB49 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.2ZBTB49 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P004291: view genomic region
(about GC identifiers)
Start:
|
4,291,924 bp from pter |
End:
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4,323,513 bp from pter |
Size:
|
31,590 bases |
Orientation:
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plus strand |
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Proteins
for ZBTB49 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT49_HUMAN, Q6ZSB9 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 49 Size: 765 amino acids; 85061 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH16477.1; Type=Erroneous termination; Positions=372; Note=Translated as Glu;
Secondary accessions: Q59FJ4 Q5EBN0 Q8TB80Alternative splicing: 2 isoforms: Q6ZSB9-1 Q6ZSB9-2 Explore the universe of human proteins at neXtProt for ZBTB49: NX_Q6ZSB9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZSB9
ZBTB49 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660334.3
ENSEMBL proteins: ENSP00000422321 ENSP00000338807 ENSP00000424525 ENSP00000425747 ENSP00000421654 ENSP00000426765 ENSP00000348091 ENSP00000445653
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZBTB49 for ontologies About GeneDecksing
ZBTB49 Antibody Products:
Assay Products for ZBTB49: |
Protein
Domains /
Families
for ZBTB49 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB49 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q6ZSB9ProtoNet protein and cluster: Q6ZSB9 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011069 Aspartate carbamoyltransferase
UniProtKB/Swiss-Prot: ZBT49_HUMAN, Q6ZSB9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 7 C2H2-type zinc fingers |
Function
for ZBTB49 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT49_HUMAN, Q6ZSB9Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB49 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB49
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB49 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZBTB49 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZBTB49:
|
Pathways & Interactions
for ZBTB49 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB49
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZBTB49 (ENSP000003388074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB49 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB49 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB49
Search CenterWatch for drugs/clinical trials and news about ZBTB49 / ZBT49
|
Transcripts
for ZBTB49 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB49 gene: NM_145291.3 Unigene Cluster for ZBTB49: Zinc finger and BTB domain containing 49 Hs.419997 [show with all ESTs]Unigene Representative Sequence: NM_1452918 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515012 ENST00000337872(uc003ghu.3 uc010icy.3) ENST00000503703(uc003ghv.3 uc010icz.3)
ENST00000502918 ENST00000504302 ENST00000511458 ENST00000355834 ENST00000538529
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB49 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB49
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB49 (NM_145291) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB49 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB49 |
Additional cDNA sequence: AB209466.1 AK095878.1 AK127560.1 AK292551.1 AL832751.1 BC016477.1 BC089401.1 BC109087.1 BC109088.1 3 DOTS entries: DT.97838065 DT.410485 DT.100019620 24/43 AceView cDNA sequences (see all 43): AW473523 CA435417 AW236515 AI968348 CA391470 BM682010 BF196920 BG764475 BF035755 BI003668 BE501704 NM_145291 AA452793 AA448473 BM729079 BX451847 AI818630 AA993690 BE551972 AK127560 AI014894 AW118893 AK095878 AA452607
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB49 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for ZBTB49
|
Expression
for ZBTB49 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB49 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTTAGTGA
About this image
See ZBTB49 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB49
SOURCE GeneReport for Unigene cluster: Hs.419997
SABiosciences Custom PCR Arrays for ZBTB49
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB49
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB49 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB49 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB49 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB49 |
Orthologs
for ZBTB49 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB49 gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZBTB491 |
zinc finger and BTB domain containing 49 |
72.44(n)
76.28(a) |
|
422847 XM_001232448.2 XP_001232449.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ZBTB496 |
-- |
60(a) |
1 ↔ 1 |
GL343236.1(668221-680500) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.241742 |
Xenopus laevis transcribed sequence with weak similarity more |
74.75(n) |
|
BJ616436.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zbtb491 |
zinc finger and BTB domain containing 49 |
59(n)
56.34(a) |
|
100009630 NM_001082999.1 NP_001076468.1 |
ENSEMBL Gene Tree for ZBTB49 (if available)
TreeFam Gene Tree for ZBTB49 (if available) |
Paralogs
for ZBTB49 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB49 gene
- ZBTB102 ZBTB32 ZBTB182 ZBTB8A2 ENSG000002545532 ZBTB442 ZBTB52 HIC12
- ZBTB242 MYNN2 ZBTB422 HIC22 GZF12 ZBTB462 ZBTB8B2 ZBTB172
18/207 SIMAP similar genes for ZBTB49 using alignment to 6 protein entries: ZBT49_HUMAN (see all proteins)
(see all similar genes):ZNF509 ZBTB7C ZFS-4 ZBTB10 KLHL3 ZNF410
ZBTB14 kr-znf3 HZF14 KLHL2 ZNF295 ZBTB21
ZBTB3 ZNF22 ZNF500 ZNF55 ZNF566 ZNF627
ZBTB49 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZBTB49
PGOHUM00000250036
|
Genomic Variants
for ZBTB49 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZBTB49
2 CNVs: 31156 3477 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB49 |
|
Disorders
/ Diseases
for ZBTB49 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZBTB49 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB49 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZBTB49) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
|
External Searches for ZBTB49 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB49 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB49 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB49 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB49 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB49 gene:
Search GeneIP for patents involving ZBTB49
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB49 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | Search Tocris compounds for ZBTB49 |
| |  |  |  |  | | | | |
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 |
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 | | | ZBTB49 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB49 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZBTB49 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB49 |
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