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Aliases for ZBTB48 Gene

Aliases for ZBTB48 Gene

  • Zinc Finger And BTB Domain Containing 48 2 3
  • HKR3 3 4 6
  • Krueppel-Related Zinc Finger Protein 3 3 4
  • GLI-Kruppel Family Member HKR3 2 3
  • Zinc Finger Protein 855 3 4
  • ZNF855 3 4
  • Zinc Finger And BTB Domain-Containing Protein 48 3
  • Protein HKR3 4
  • Pp9964 3

External Ids for ZBTB48 Gene

Previous HGNC Symbols for ZBTB48 Gene

  • HKR3

Previous GeneCards Identifiers for ZBTB48 Gene

  • GC01P006562
  • GC01P006640
  • GC01P005788

Summaries for ZBTB48 Gene

GeneCards Summary for ZBTB48 Gene

ZBTB48 (Zinc Finger And BTB Domain Containing 48) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for ZBTB48 Gene

  • Binds to and regulates the J and/or S elements in MHC II promoter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB48 Gene

Genomics for ZBTB48 Gene

Regulatory Elements for ZBTB48 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBTB48 Gene

Start:
6,579,991 bp from pter
End:
6,589,280 bp from pter
Size:
9,290 bases
Orientation:
Plus strand

Genomic View for ZBTB48 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB48 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB48 Gene

Proteins for ZBTB48 Gene

  • Protein details for ZBTB48 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10074-ZBT48_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 48
    Protein Accession:
    P10074
    Secondary Accessions:
    • Q5SY19

    Protein attributes for ZBTB48 Gene

    Size:
    688 amino acids
    Molecular mass:
    77054 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZBTB48 Gene

neXtProt entry for ZBTB48 Gene

Proteomics data for ZBTB48 Gene at MOPED

Post-translational modifications for ZBTB48 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB48 Gene

No data available for DME Specific Peptides for ZBTB48 Gene

Domains for ZBTB48 Gene

Gene Families for ZBTB48 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZBTB48 Gene

Graphical View of Domain Structure for InterPro Entry

P10074

UniProtKB/Swiss-Prot:

ZBT48_HUMAN :
  • P10074
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB48: view

Function for ZBTB48 Gene

Molecular function for ZBTB48 Gene

UniProtKB/Swiss-Prot Function: Binds to and regulates the J and/or S elements in MHC II promoter.

Gene Ontology (GO) - Molecular Function for ZBTB48 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8661141
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB48: view

Phenotypes for ZBTB48 Gene

GenomeRNAi human phenotypes for ZBTB48:
genes like me logo Genes that share phenotypes with ZBTB48: view

Animal Model Products

CRISPR Products

miRNA for ZBTB48 Gene

miRTarBase miRNAs that target ZBTB48

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB48

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB48 Gene

Localization for ZBTB48 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB48 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB48 Gene COMPARTMENTS Subcellular localization image for ZBTB48 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZBTB48 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB48: view

Pathways for ZBTB48 Gene

SuperPathways for ZBTB48 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB48 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB48: view

No data available for Pathways by source for ZBTB48 Gene

Transcripts for ZBTB48 Gene

Unigene Clusters for ZBTB48 Gene

Zinc finger and BTB domain containing 48:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB48

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB48 Gene

No ASD Table

Relevant External Links for ZBTB48 Gene

GeneLoc Exon Structure for
ZBTB48
ECgene alternative splicing isoforms for
ZBTB48

Expression for ZBTB48 Gene

mRNA expression in normal human tissues for ZBTB48 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB48 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZBTB48 Gene

SOURCE GeneReport for Unigene cluster for ZBTB48 Gene Hs.502330

mRNA Expression by UniProt/SwissProt for ZBTB48 Gene

P10074-ZBT48_HUMAN
Tissue specificity: Detected in adrenal gland and neuroblastoma.
genes like me logo Genes that share expressions with ZBTB48: view

In Situ Assay Products

Orthologs for ZBTB48 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB48 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB48 35
  • 99.66 (n)
  • 99.85 (a)
ZBTB48 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB48 35
  • 89.78 (n)
  • 92.59 (a)
ZBTB48 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB48 35
  • 89.87 (n)
  • 93.75 (a)
ZBTB48 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb48 35
  • 87.37 (n)
  • 91.78 (a)
Zbtb48 16
Zbtb48 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB48 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB48 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb48 35
  • 87.47 (n)
  • 91.34 (a)
chicken
(Gallus gallus)
Aves ZBTB48 35
  • 72.64 (n)
  • 75.99 (a)
ZBTB48 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB48 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12958 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb48 35
  • 63.45 (n)
  • 62.81 (a)
zebrafish
(Danio rerio)
Actinopterygii zbtb48 35
  • 59.2 (n)
  • 56.43 (a)
zbtb48 36
  • 50 (a)
OneToOne
Species with no ortholog for ZBTB48:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB48 Gene

ENSEMBL:
Gene Tree for ZBTB48 (if available)
TreeFam:
Gene Tree for ZBTB48 (if available)

Paralogs for ZBTB48 Gene

genes like me logo Genes that share paralogs with ZBTB48: view

Variants for ZBTB48 Gene

Sequence variations from dbSNP and Humsavar for ZBTB48 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs731024 -- 6,584,663(+) TTCAA(A/G)TACTC intron-variant
rs1042775 -- 6,589,219(+) CCATT(C/T)TGGCC utr-variant-3-prime, nc-transcript-variant
rs1804904 -- 6,589,113(+) CTCCC(C/T)GGCCA reference, synonymous-codon, nc-transcript-variant
rs2010443 -- 6,588,861(+) CCTGG(C/G)CCCCT intron-variant
rs2229329 -- 6,580,601(+) CTGCC(C/T)TCCAG utr-variant-5-prime, upstream-variant-2KB, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB48 Gene

Variant ID Type Subtype PubMed ID
nsv7880 CNV Gain+Loss 18304495
nsv831536 CNV Loss 17160897
nsv831647 CNV Loss 17160897
dgv129n71 CNV Loss 21882294
nsv871348 CNV Gain 21882294
nsv870646 CNV Loss 21882294

Relevant External Links for ZBTB48 Gene

HapMap Linkage Disequilibrium report
ZBTB48

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB48 Gene

Disorders for ZBTB48 Gene

No disorders were found for ZBTB48 Gene.

No data available for UniProtKB/Swiss-Prot for ZBTB48 Gene

Publications for ZBTB48 Gene

  1. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert J.M. … Vogelstein B. (Mol. Cell. Biol. 1988) 2 3 4
  2. A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein. (PMID: 7969177) Sugawara M. … Strominger J.L. (Mol. Cell. Biol. 1994) 3 4
  3. Cloning, chromosomal localization, physical mapping, and genomic characterization of HKR3. (PMID: 8661141) Maris J.M. … White P.S. (Genomics 1996) 2 3
  4. Human Kruppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene? (PMID: 9516840) Maris J.M. … White P.S. (Eur. J. Cancer 1997) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZBTB48 Gene

Sources for ZBTB48 Gene

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