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ZBTB47 Gene

protein-coding   GIFtS: 43

GC03P042674
zinc finger and BTB domain containing 47
(Previous name: zinc finger protein 651 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF651)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp434N0615 1, 2
KIAA1190 1, 2, 3
ZNF651 2, 3
Descriptions
Zinc finger protein 651 1, 2, 3
zinc finger and BTB domain containing 47 2
External Ids
HGNC: 269551
Entrez Gene: 929992
UniProtKB: Q9UFB73
Ensembl: ENSG000001148537
Search outside databases for aliases for ZBTB47 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7
Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22.1

ZBTB47 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P042674:     (about GC identifiers)

Start:
42,674,852 bp from pter
End:
42,684,076 bp from pter
Size:
9,225 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000003.10  NT_022517.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 47  
Size: 371 amino acids; 42465 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q8WTY8 Q9ULN0

REFSEQ proteins: NP_660149.1  

ENSEMBL proteins: 
ENSP00000232974 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ZNF651)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
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Antibodies for ZBTB47: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for ZBTB47
Browse R&D Systems for Antibodies
Antibodies from Abcam (ZNF651), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for ZBTB47

Assays for ZBTB47: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro domains/families:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2


   GeneDecks  ZBTB47 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9UFB7

ProtoNet protein and cluster: Q9UFB7

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 9 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBTB47)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZNF651)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC021855

              Applied Biosystems Silencer® siRNAs for ZBTB47

              Sigma-Aldrich siRNA for ZBTB47  
                     Sigma-Aldrich shRNA for ZBTB47  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145166
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145166
                                 untagged cDNA clones in CMV expression vector (see all 2): BC021855 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_145166

UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7
Function: May be involved in transcriptional regulation

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB47

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBTB47)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZNF651)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC021855

              Sigma-Aldrich siRNA for ZBTB47  
                     Sigma-Aldrich shRNA for ZBTB47  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_145166  

REFSEQ mRNAs for ZBTB47 gene: 

NM_145166.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_145166  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145166
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145166
                                 untagged cDNA clones in CMV expression vector (see all 2): BC021855 

Additional cDNA sequence: 

AB033016.1 AK127065.1 AL133062.1 BC021855.1 

6 DOTS entries:

DT.86996907  DT.215143  DT.100009678  DT.91741348  DT.91873311  DT.100741924 

24/96 AceView cDNA sequences (see all 96 ):

BU743025 BM984714 BM700666 NM_145166 BM856386 BM718586 Z41509 AI937491 
AI471220 BM830427 BM674023 F24608 BM785547 AI380709 AL133062 BP343496 
BU620464 BX099471 F05045 BM701135 W95172 AB033016 BF530692 BC021855 

highest scoring ESTs for ZBTB47:

AA195855 AI806872 AA027954 AA228317 AA228388 AA228858 AA234469 AA234493 AA479581 AA532640 

Unigene Cluster for ZBTB47:

Zinc finger and BTB domain containing 47
Hs.409561  [show with all ESTs]
Unigene Representative Sequence: NM_145166


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000232974  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB47 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB47

1 / 2 / 3

9 probe-sets matching ZBTB47 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
63804_at2, 3 U95-C 1 1.00 1.00 0.95 1.11 AA195855 1.00 1.00 1.00 1
68093_at2, 3 U95-E 2 1.00 0.97 0.84 0.73 T23179 0.80 1.00 0.91 1
49410_at2, 3 U95-B 1 0.94 1.00 0.97 1.17 AI806872 1.00 1.00 1.00 1

226500_at2, 3 U133-B 1 1.00 1.00 -- -- AI806872 1.00 1.00 1.00 1

234338_s_at2, 3 U133-B 1 1.00 1.00 -- -- AL133062 0.80 1.00 0.91 1

226484_at2, 3 U133-B 1 1.00 1.00 -- -- AA532640 0.80 1.00 0.91 1

226500_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

234338_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

226484_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  ZBTB47 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CGAGTGAGAG

SOURCE GeneReport for Unigene cluster: Hs.409561
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ZBTB47 gene from 2 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
zebrafish
(Danio rerio)
LOC1001503731   -- similar to zinc finger protein 651 78.24(n)
85.03(a)
100150373  XM_001921240.1  XP_001921275.1 
African clawed frog
(Xenopus laevis)
Xl.133142   -- Xenopus laevis transcribed sequence with strong similarity more 86.79(n)  BJ069016.1 
About this table        Species with no ortholog for ZBTB47

ENSEMBL Gene Tree for ZBTB47
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ZBTB47 gene
ZNF6522  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/49 NCBI SNPs in ZBTB47 are shown (see all 49 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 35)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 3 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs111299671,2
A,C,F,H42682285(+) GAGGCG/ACAGCC 1 -- ut31 ese34Minor allele frequency- A:0.25EU EA WA 420
rs22909761,2
C,F,H42683636(-) CTAGTC/TGCCTC 1 -- ut31 ese313Minor allele frequency- T:0.09EA EU WA NA 2684
rs3397241,2
A,C,F42675460(-) GCTGGG/AGGCCC 1 -- ng51 ese31Minor allele frequency- A:0.37MN 184
rs37330611,2
A,C,F42683171(+) TAGGCC/GTGAGT 1 -- ut31 ese31Minor allele frequency- G:0.07EA 1484
rs38886511,2
C,F,H42674124(+) TCAACT/GTCTGC 1 -- ng5112Minor allele frequency- G:0.27EU EA WA NA 1198
rs3397231,2
A,C42675634(-) GTGGCC/TGGGCT 1 -- ng51 ese30--------
rs98782391,2
A,H42676004(+) AGAACG/ACCCGG 1 T/A mis14Minor allele frequency- A:0.00EU EA WA 410
--
rs827551,2
A,C42674371(+) cctgcG/Tatggt 1 -- ng510--------
--
rs3397221,2
A,C42675700(-) tcctcC/Gtcgtc 1 -- ng51 ese30--------
rs22909771,2
F42683570(-) GATGTA/GAAAGC 1 -- ut31 ese31Minor allele frequency- G:0.01EA 1502
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HapMap Linkage Disequilibrium images for ZBTB47 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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4 PubMed articles for ZBTB47 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 92999 HGNC: 26955 AceView: KIAA1190 Ensembl:ENSG00000114853 euGenes: HUgn92999
ECgene: ZBTB47 H-InvDB: ZBTB47
(According to HUGE)
About This Section

HUGE: KIAA1190
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ZBTB47:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB47-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for ZBTB47 Antibodies for ZBTB47
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 Search Novus for antibodies for ZBTB47

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