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ZBTB47 Gene

protein-coding   GIFtS: 45
GCID: GC03P042695

Zinc Finger And BTB Domain Containing 47

(Previous name: zinc finger protein 651)
(Previous symbol: ZNF651)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 471 2
Zinc Finger Protein 6511 2 3
ZNF6511 2 3
Zinc Finger And BTB Domain-Containing Protein 472
KIAA11903

External Ids:    HGNC: 269551   Entrez Gene: 929992   Ensembl: ENSG000001148537   UniProtKB: Q9UFB73   

Export aliases for ZBTB47 gene to outside databases

Previous GC identifer: GC03P042674


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZBTB47 Gene:
ZBTB47 (zinc finger and BTB domain containing 47) is a protein-coding gene. An important paralog of this gene is ZNF652.

UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB47 gene promoter:
         STAT1   STAT4   STAT1beta   STAT6   STAT5A   STAT1alpha   c-Ets-1   HOXA5   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB47 promoter sequence
   Search Chromatin IP Primers for ZBTB47

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB47


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22.1

ZBTB47 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB47 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P042695:  view genomic region     (about GC identifiers)

Start:
42,695,176 bp from pter      End:
42,709,072 bp from pter
Size:
13,897 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 47  
Size: 371 amino acids; 42465 Da
Secondary accessions: Q8WTY8 Q9ULN0

Explore the universe of human proteins at neXtProt for ZBTB47: NX_Q9UFB7

Explore proteomics data for ZBTB47 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZBTB47 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660149.2  
    ENSEMBL proteins: 
     ENSP00000232974   ENSP00000420968   ENSP00000411491  

    ZBTB47 Human Recombinant Protein Products:

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    antibodies-online peptides for ZBTB47

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    antibodies-online antibodies for ZBTB47 (11 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UFB7

    ProtoNet protein and cluster: Q9UFB7

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers


    Find genes that share domains with ZBTB47           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT47_HUMAN, Q9UFB7
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZBTB47           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZBTB47

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZBTB47:
    hsa-mir-106a-5p (MIRT048322), hsa-mir-21-5p (MIRT030701), hsa-mir-28-5p (MIRT049998)

    Block miRNA regulation of human, mouse, rat ZBTB47 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBTB47 (see all 77):
    hsa-miR-549 hsa-miR-3938 hsa-miR-520e hsa-miR-520f hsa-miR-4254 hsa-miR-106a hsa-miR-4267 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: ZBTB47 (NM_145166)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZBT47_HUMAN, Q9UFB7: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZBTB47           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB47
    Interactions:

        Search GeneGlobe Interaction Network for ZBTB47

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZBTB47 (Q9UFB72, 3 ENSP000004114914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBFA2T3O750812, 3, ENSP000002686794MINT-7555667 I2D: score=1 STRING: ENSP00000268679
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZBTB47           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB47 (ZBT47)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZBTB47 gene: 
    NM_145166.3  

    Unigene Cluster for ZBTB47:

    Zinc finger and BTB domain containing 47
    Hs.409561  [show with all ESTs]
    Unigene Representative Sequence: NM_145166
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232974 ENST00000505904 ENST00000457842(uc003clu.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZBTB47 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBTB47 (see all 77):
    hsa-miR-549 hsa-miR-3938 hsa-miR-520e hsa-miR-520f hsa-miR-4254 hsa-miR-106a hsa-miR-4267 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZBTB47
      QuantiFast Probe-based Assays in human, mouse, rat ZBTB47

    Additional mRNA sequence: 

    AB033016.1 AK127065.1 AL133062.1 BC021855.1 

    6 DOTS entries:

    DT.86996907  DT.215143  DT.100009678  DT.91741348  DT.100741924  DT.91873311 

    Selected AceView cDNA sequences (see all 96):

    BU620464 AI380709 BM701135 NM_145166 BM674023 AL133062 BF530692 BM700666 
    Z41509 AB033016 BU743025 BC021855 BM830427 F05045 BP343496 BM718586 
    F24608 BM984714 AI471220 AI937491 W95172 BX099471 BM856386 BM785547 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBTB47 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAGTGAGAG
    ZBTB47 Expression
    About this image

    ZBTB47 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB47 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.409561
        Custom PCR Arrays for ZBTB47
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB47

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB47 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6515 zinc finger protein 651   --   9 (72.60 cM) 121760033 
    chicken
    (Gallus gallus)
    Aves ZBTB476
    zinc finger and BTB domain containing 47
    71(a)
    1 ↔ 1
    2(1978851-1993362)
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB476
    zinc finger and BTB domain containing 47
    64(a)
    1 ↔ 1
    6(2703474-2712272)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133142 Xenopus laevis transcribed sequence with strong similarity more 86.79(n)    BJ069016.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zbtb47b6
    zbtb47a6
    zinc finger and BTB domain containing 47a
    94(a)
    54(a)
    many → 1
    many → 1
    24(21198130-21208332) ENSDARG00000079547
    2(21105272-21117749) ENSDARG00000057751


    ENSEMBL Gene Tree for ZBTB47 (if available)
    TreeFam Gene Tree for ZBTB47 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBTB47 gene
    ZNF6522  
    Selected SIMAP similar genes for ZBTB47 using alignment to 3 protein entries:     ZBT47_HUMAN (see all proteins) (see all similar genes):
    ZNF148    DKFZp434J0650    ZBTB21    ZNF652    ZNF775    kr-znf3
    ZNF72    ZNF78L1    ZFS-2    KLHL32    ZFS-4    ZNF214
    A-328A3.4    HZF16    ZFP41    ZNF    ZNF227    ZNF55

    Find genes that share paralogs with ZBTB47           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZBTB47 (see all 262)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866096391,2
    --42693188(+) TCTCCC/TTCTTC 1 -- us2k10--------
    rs1466964731,2
    C--42693228(+) CCTCCA/GGGCTG 1 -- us2k10--------
    rs1402742841,2
    --42693265(+) CATACA/GCATAC 1 -- us2k10--------
    rs1454700711,2
    --42693357(+) AGGGTA/GGATAC 1 -- us2k10--------
    rs1927465381,2
    --42693407(+) AGGCAC/GGGGCA 1 -- us2k10--------
    rs1380638651,2
    --42693487(+) GTGAGC/TGTCTC 1 -- us2k10--------
    rs1847371201,2
    --42693504(+) CCTGAC/TTCACC 1 -- us2k10--------
    rs1148966021,2
    F--42693543(+) TCAACT/GCCCCA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1408170931,2
    --42693549(+) CCCCAA/GTAACT 1 -- us2k10--------
    rs1895144701,2
    --42694108(+) CCCAGC/TAAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZBTB47 (42695176 - 42709072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZBTB47:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3781CNV Insertion18451855
    nsv876731CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB47
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB47

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBTB47 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZBTB47)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (DNA Res. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. CBFA2T3-ZNF651, like CBFA2T3-ZNF652, functions as a transcriptional corepressor complex. (PubMed id 20116376)1 Kumar R....Callen D.F. (FEBS Lett. 2010)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92999 HGNC: 26955 AceView: KIAA1190 Ensembl:ENSG00000114853 euGenes: HUgn92999
    ECgene: ZBTB47 H-InvDB: ZBTB47

    (According to HUGE)
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    HUGE: KIAA1190

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZBTB47 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZBTB47 gene:
    Search GeneIP for patents involving ZBTB47

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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