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ZBTB47 Gene

protein-coding GIFtS: 43

GC03P042674

zinc finger and BTB domain containing 47
(Previous name: zinc finger protein 651 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF651)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp434N0615 ^¹, ²
KIAA1190 ^¹, ², ³
ZNF651 ^², ³

Descriptions
Zinc finger protein 651 ^¹, ², ³
zinc finger and BTB domain containing 47 ^²

External Ids
HGNC: 26955¹
Entrez Gene: 92999²
UniProtKB: Q9UFB7³
Ensembl: ENSG00000114853⁷

Search outside databases for aliases for ZBTB47 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3p22.1

ZBTB47 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P042674: (about GC identifiers)

Start:	42,674,852 bp from pter
End:	42,684,076 bp from pter
Size:	9,225 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 47

Size: 371 amino acids; 42465 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: Q8WTY8 Q9ULN0

REFSEQ proteins: NP_660149.1

ENSEMBL proteins:

ENSP00000232974

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZNF651)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

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Antibodies for ZBTB47:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBTB47
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZNF651), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZBTB47

Assays for ZBTB47:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9UFB7

ProtoNet protein and cluster: Q9UFB7

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 9 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB47)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZNF651)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC021855

Applied Biosystems Silencer® siRNAs for ZBTB47

Sigma-Aldrich siRNA for ZBTB47

Sigma-Aldrich shRNA for ZBTB47

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_145166
Myc/DDK tagged cDNA clone in CMV expression vector: NM_145166
untagged cDNA clones in CMV expression vector (see all 2): BC021855

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_145166

UniProtKB/Swiss-Prot: ZBT47_HUMAN, Q9UFB7

Function: May be involved in transcriptional regulation

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB47

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB47)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZNF651)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC021855

Sigma-Aldrich siRNA for ZBTB47

Sigma-Aldrich shRNA for ZBTB47

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_145166

REFSEQ mRNAs for ZBTB47 gene:

NM_145166.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_145166

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145166
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145166
                                 untagged cDNA clones in CMV expression vector (see all 2): BC021855

Additional cDNA sequence:

AB033016.1 AK127065.1 AL133062.1 BC021855.1

6 DOTS entries:

DT.86996907 DT.215143 DT.100009678 DT.91741348 DT.91873311 DT.100741924

24/96 AceView cDNA sequences (see all 96 ):

BU743025 BM984714 BM700666 NM_145166 BM856386 BM718586 Z41509 AI937491

AI471220 BM830427 BM674023 F24608 BM785547 AI380709 AL133062 BP343496

BU620464 BX099471 F05045 BM701135 W95172 AB033016 BF530692 BC021855

highest scoring ESTs for ZBTB47:

AA195855 AI806872 AA027954 AA228317 AA228388 AA228858 AA234469 AA234493 AA479581 AA532640

Unigene Cluster for ZBTB47:

Zinc finger and BTB domain containing 47

Hs.409561 [show with all ESTs]

Unigene Representative Sequence: NM_145166

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000232974

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB47 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB47

¹ / ² / ³

9 probe-sets matching ZBTB47 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
63804_at²^{, 3}	U95-C	1	1.00	1.00	0.95	1.11	AA195855	1.00	1.00	1.00	1
68093_at²^{, 3}	U95-E	2	1.00	0.97	0.84	0.73	T23179	0.80	1.00	0.91	1
49410_at²^{, 3}	U95-B	1	0.94	1.00	0.97	1.17	AI806872	1.00	1.00	1.00	1
226500_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI806872	1.00	1.00	1.00	1
234338_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL133062	0.80	1.00	0.91	1
226484_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA532640	0.80	1.00	0.91	1
226500_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234338_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226484_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZBTB47 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGAGTGAGAG

SOURCE GeneReport for Unigene cluster: Hs.409561

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ZBTB47 gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
zebrafish (Danio rerio)	LOC100150373¹	--	similar to zinc finger protein 651	78.24(n) 85.03(a)	100150373 XM_001921240.1 XP_001921275.1
African clawed frog (Xenopus laevis)	Xl.13314²	--	Xenopus laevis transcribed sequence with strong similarity more	86.79(n)	BJ069016.1

About this table Species with no ortholog for ZBTB47

ENSEMBL Gene Tree for ZBTB47

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB47 gene

ZNF652²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/49 NCBI SNPs in ZBTB47 are shown (see all 49 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11129967^1,2	A,C,F,H	42682285(+)	`GAGGCG/ACAGCC`	1	--	ut3¹ ese³		4		EU EA WA	420
	rs2290976^1,2	C,F,H	42683636(-)	`CTAGTC/TGCCTC`	1	--	ut3¹ ese³		13		EA EU WA NA	2684
	rs339724^1,2	A,C,F	42675460(-)	`GCTGGG/AGGCCC`	1	--	ng5¹ ese³		1		MN	184
	rs3733061^1,2	A,C,F	42683171(+)	`TAGGCC/GTGAGT`	1	--	ut3¹ ese³		1		EA	1484
	rs3888651^1,2	C,F,H	42674124(+)	`TCAACT/GTCTGC`	1	--	ng5¹		12		EU EA WA NA	1198
	rs339723^1,2	A,C	42675634(-)	`GTGGCC/TGGGCT`	1	--	ng5¹ ese³		0	--	--	--	--
	rs9878239^1,2	A,H	42676004(+)	`AGAACG/ACCCGG`	1	T/A	mis¹		4		EU EA WA	410
--	rs82755^1,2	A,C	42674371(+)	`cctgcG/Tatggt`	1	--	ng5¹		0	--	--	--	--
--	rs339722^1,2	A,C	42675700(-)	`tcctcC/Gtcgtc`	1	--	ng5¹ ese³		0	--	--	--	--
	rs2290977^1,2	F	42683570(-)	`GATGTA/GAAAGC`	1	--	ut3¹ ese³		1		EA	1502

About this table

HapMap Linkage Disequilibrium images for ZBTB47 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for ZBTB47 gene:

Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)^{2, 3, 4} Hirosawa M....Ohara O. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 92999	HGNC: 26955	AceView: KIAA1190	Ensembl:ENSG00000114853	euGenes: HUgn92999
ECgene: ZBTB47	H-InvDB: ZBTB47

(According to HUGE)
About This Section

HUGE: KIAA1190

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBTB47
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB47:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB47-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB47		Antibodies for ZBTB47
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBTB47		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
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	Chimera RNAi (ZNF651)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ZNF651)
	Antibodies (ZNF651)

Search OriGene for ZBTB47

Search Tocris compounds for ZBTB47

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ZBTB47

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ZBTB47 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for ZBTB47

Summaries
for ZBTB47

Genomic Location
for ZBTB47

Proteins
for ZBTB47

Protein Domains/
Families
for ZBTB47

Gene Function
for ZBTB47

Pathways & Interactions
for ZBTB47

Drugs & Compounds
for ZBTB47

Transcripts
for ZBTB47

Expression
for ZBTB47

Orthologs
for ZBTB47

Paralogs
for ZBTB47

SNPs/Variants
for ZBTB47

Disorders & Mutations
for ZBTB47

Medical News
for ZBTB47

Publications
for ZBTB47

Search for ZBTB47

Genome Databases showing ZBTB47

Other Databases showing ZBTB47

Specialized Databases showing ZBTB47

Licensable Technologies
for ZBTB47

Services
for ZBTB47

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB47 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor ZBTB47

Summariesfor ZBTB47

Genomic Locationfor ZBTB47

Proteinsfor ZBTB47

Protein Domains/Familiesfor ZBTB47

Gene Functionfor ZBTB47

Pathways & Interactionsfor ZBTB47

Drugs & Compoundsfor ZBTB47

Transcriptsfor ZBTB47

Expression for ZBTB47

Orthologsfor ZBTB47

Paralogsfor ZBTB47

SNPs/Variantsfor ZBTB47

Disorders & Mutationsfor ZBTB47

Medical Newsfor ZBTB47

Publicationsfor ZBTB47

Search for ZBTB47

Genome Databases showing ZBTB47

Other Databases showing ZBTB47

Specialized Databases showing ZBTB47

Licensable Technologiesfor ZBTB47

Servicesfor ZBTB47

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB47

Summaries
for ZBTB47

Genomic Location
for ZBTB47

Proteins
for ZBTB47

Protein Domains/
Families
for ZBTB47

Gene Function
for ZBTB47

Pathways & Interactions
for ZBTB47

Drugs & Compounds
for ZBTB47

Transcripts
for ZBTB47

Expression
for ZBTB47

Orthologs
for ZBTB47

Paralogs
for ZBTB47

SNPs/Variants
for ZBTB47

Disorders & Mutations
for ZBTB47

Medical News
for ZBTB47

Publications
for ZBTB47

Licensable Technologies
for ZBTB47

Services
for ZBTB47