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Aliases for ZBTB46 Gene

Aliases for ZBTB46 Gene

  • Zinc Finger And BTB Domain Containing 46 2 3 5
  • BTB-ZF Protein Expressed In Effector Lymphocytes 2 3 4
  • BTB/POZ Domain-Containing Protein 4 3 4
  • BTB (POZ) Domain Containing 4 2 3
  • Zinc Finger Protein 340 3 4
  • ZNF340 3 4
  • BTBD4 3 4
  • BZEL 3 4
  • Zinc Finger And BTB Domain-Containing Protein 46 3
  • DJ583P15.7 3
  • DJ583P15.8 3
  • RINZF 3

External Ids for ZBTB46 Gene

Previous HGNC Symbols for ZBTB46 Gene

  • ZNF340
  • BTBD4

Previous GeneCards Identifiers for ZBTB46 Gene

  • GC20M061845
  • GC20M062375
  • GC20M059108

Summaries for ZBTB46 Gene

GeneCards Summary for ZBTB46 Gene

ZBTB46 (Zinc Finger And BTB Domain Containing 46) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBTB10.

UniProtKB/Swiss-Prot for ZBTB46 Gene

  • Function as a transcriptional repressor for PRDM1.

Additional gene information for ZBTB46 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB46 Gene

Genomics for ZBTB46 Gene

Regulatory Elements for ZBTB46 Gene

Enhancers for ZBTB46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H063893 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -64.3 -64348 5.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 DIDO1 UCKL1 MIR647 GMEB2 PRPF6 RGS19 RTEL1 OPRL1 ZBTB46 C20orf181
GH20H063853 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -22.8 -22838 3.5 ELF3 HDGF NFIB RB1 DMAP1 DNMT3B THRB ZSCAN9 ZNF207 RUNX3 ZBTB46 ZBTB46-AS1 DNAJC5 UCKL1 ABHD16B HELZ2 GC20M063809
GH20H063863 1.4 ENCODE dbSUPER 11.8 -32.5 -32528 3.6 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC PPARGC1A DIDO1 PRPF6 GMEB2 CICP4 ENSG00000237371 UCKL1 RTEL1 MIR647 ARFRP1 DNAJC5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB46 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139965 1344 2401 ELF3 RB1 ARID4B SIN3A BMI1 DNMT3B SLC30A9 ZNF766 ELK1 EGR1

Genomic Locations for ZBTB46 Gene

Genomic Locations for ZBTB46 Gene
88,679 bases
Minus strand

Genomic View for ZBTB46 Gene

Genes around ZBTB46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB46 Gene

Proteins for ZBTB46 Gene

  • Protein details for ZBTB46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 46
    Protein Accession:
    Secondary Accessions:
    • E1P5K9
    • Q5JWJ3
    • Q6GMV4
    • Q9BQK3
    • Q9H3Z8
    • Q9H3Z9

    Protein attributes for ZBTB46 Gene

    589 amino acids
    Molecular mass:
    64083 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB46 Gene

Post-translational modifications for ZBTB46 Gene

  • Sumoylated. Desumoylation by PPPDE2 reverses transcriptional repression activity (By similarity).
  • Ubiquitination at isoforms=46
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZBTB46 Gene

Domains & Families for ZBTB46 Gene

Gene Families for ZBTB46 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB46 Gene

Suggested Antigen Peptide Sequences for ZBTB46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB46: view

No data available for UniProtKB/Swiss-Prot for ZBTB46 Gene

Function for ZBTB46 Gene

Molecular function for ZBTB46 Gene

UniProtKB/Swiss-Prot Function:
Function as a transcriptional repressor for PRDM1.

Phenotypes From GWAS Catalog for ZBTB46 Gene

Gene Ontology (GO) - Molecular Function for ZBTB46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB46: view
genes like me logo Genes that share phenotypes with ZBTB46: view

Animal Models for ZBTB46 Gene

MGI Knock Outs for ZBTB46:

Animal Model Products

CRISPR Products

miRNA for ZBTB46 Gene

miRTarBase miRNAs that target ZBTB46

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB46 Gene

Localization for ZBTB46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB46 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB46 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB46: view

Pathways & Interactions for ZBTB46 Gene

SuperPathways for ZBTB46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030853 negative regulation of granulocyte differentiation IEA --
GO:0045650 negative regulation of macrophage differentiation IEA --
GO:0045656 negative regulation of monocyte differentiation IEA --
genes like me logo Genes that share ontologies with ZBTB46: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB46 Gene

Drugs & Compounds for ZBTB46 Gene

No Compound Related Data Available

Transcripts for ZBTB46 Gene

Unigene Clusters for ZBTB46 Gene

Zinc finger and BTB domain containing 46:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB46 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - -
SP4: -

Relevant External Links for ZBTB46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB46 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for ZBTB46 Gene

This gene is overexpressed in Plasma (37.3) and Ovary (31.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB46 Gene

Protein tissue co-expression partners for ZBTB46 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB46 Gene:


SOURCE GeneReport for Unigene cluster for ZBTB46 Gene:


Evidence on tissue expression from TISSUES for ZBTB46 Gene

  • Spleen(2.3)
genes like me logo Genes that share expression patterns with ZBTB46: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB46 Gene

Orthologs for ZBTB46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB46 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB46 33 34
  • 98.98 (n)
(Canis familiaris)
Mammalia LOC485980 33
  • 87.17 (n)
ZBTB46 34
  • 75 (a)
(Bos Taurus)
Mammalia ZBTB46 33 34
  • 86.15 (n)
(Rattus norvegicus)
Mammalia Zbtb46 33
  • 84.69 (n)
(Mus musculus)
Mammalia Zbtb46 33 16 34
  • 84.35 (n)
(Monodelphis domestica)
Mammalia ZBTB46 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB46 34
  • 79 (a)
(Gallus gallus)
Aves ZBTB46 33 34
  • 78.69 (n)
(Anolis carolinensis)
Reptilia ZBTB46 34
  • 78 (a)
(Danio rerio)
Actinopterygii zbtb46 33 34
  • 70.75 (n)
Species where no ortholog for ZBTB46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB46 Gene

Gene Tree for ZBTB46 (if available)
Gene Tree for ZBTB46 (if available)

Paralogs for ZBTB46 Gene

(13) SIMAP similar genes for ZBTB46 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB46: view

Variants for ZBTB46 Gene

Sequence variations from dbSNP and Humsavar for ZBTB46 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000021453 -- 63,816,729(+) GTCTT(C/T)GCAAA intron-variant
rs1000050635 -- 63,827,851(+) TACTT(A/G)GGTCA intron-variant
rs1000060675 -- 63,750,934(+) ACCCT(A/C)TCCAA intron-variant
rs1000078560 -- 63,831,471(+) CCGCG(A/G)GGTCG intron-variant, upstream-variant-2KB
rs1000088133 -- 63,818,184(+) GACAA(A/G)GGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB46 Gene

Variant ID Type Subtype PubMed ID
nsv953308 CNV deletion 24416366
nsv828803 CNV gain 20364138
nsv828802 CNV loss 20364138
nsv586646 CNV loss 21841781
nsv470563 CNV loss 18288195
nsv459087 CNV loss 19166990
nsv428381 CNV gain+loss 18775914
nsv180391 CNV insertion 16902084
nsv179829 CNV deletion 16902084
nsv179256 CNV insertion 16902084
nsv1160690 CNV deletion 26073780
nsv1154145 CNV deletion 26484159
nsv1149320 CNV deletion 26484159
nsv1145946 CNV deletion 26484159
nsv1142534 CNV deletion 24896259
nsv1123503 CNV deletion 24896259
nsv1116882 CNV deletion 24896259
nsv1059142 CNV gain 25217958
esv7227 CNV loss 19470904
esv4299 CNV loss 18987735
esv3646327 CNV loss 21293372
esv3646326 CNV loss 21293372
esv3557371 CNV deletion 23714750
esv3384823 CNV insertion 20981092
esv3343882 CNV insertion 20981092
esv2758806 CNV gain+loss 17122850
esv2722974 CNV deletion 23290073
esv2722972 CNV deletion 23290073
esv2722971 CNV deletion 23290073
esv2722970 CNV deletion 23290073
esv2722969 CNV deletion 23290073
esv2722968 CNV deletion 23290073
esv2722967 CNV deletion 23290073
esv2722959 CNV deletion 23290073
esv2671555 CNV deletion 23128226
esv1348867 CNV deletion 17803354
esv1008032 CNV deletion 20482838
esv1000629 CNV deletion 20482838
dgv7684n54 CNV loss 21841781
dgv523n27 CNV loss 19166990
dgv2294n106 CNV deletion 24896259

Variation tolerance for ZBTB46 Gene

Residual Variation Intolerance Score: 5.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB46 Gene

Disorders for ZBTB46 Gene

Relevant External Links for ZBTB46

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZBTB46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB46 Gene

Publications for ZBTB46 Gene

  1. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for ZBTB46 Gene

Sources for ZBTB46 Gene

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