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ZBTB46 Gene

protein-coding   GIFtS: 49
GCID: GC20M062375

Zinc Finger And BTB Domain Containing 46

(Previous name: BTB (POZ) domain containing 4)
(Previous symbols: ZNF340, BTBD4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 461 2     Zinc Finger Protein 3402 3
BTBD41 2 3     BTB/POZ Domain-Containing Protein 42 3
ZNF3401 2 3     RINZF2
BTB-ZF Protein Expressed In Effector Lymphocytes1 2 3     dJ583P15.72
BZEL2 3 5     dJ583P15.82
BTB (POZ) Domain Containing 41 2     Zinc Finger And BTB Domain-Containing Protein 462

External Ids:    HGNC: 160941   Entrez Gene: 1406852   Ensembl: ENSG000001305847   OMIM: 6146395   UniProtKB: Q86UZ63   

Export aliases for ZBTB46 gene to outside databases

Previous GC identifers: GC20M061845 GC20M059108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZBTB46 Gene:
ZBTB46 (zinc finger and BTB domain containing 46) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBTB10.

UniProtKB/Swiss-Prot: ZBT46_HUMAN, Q86UZ6
Function: Function as a transcriptional repressor for PRDM1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB46 gene promoter:
         HOXA9B   HOXA9   STAT1   STAT1beta   Meis-1b   STAT1alpha   MEF-2A   aMEF-2   RSRFC4   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB46 promoter sequence
   Search Chromatin IP Primers for ZBTB46

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB46


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

ZBTB46 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB46 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062375:  view genomic region     (about GC identifiers)

Start:
62,375,019 bp from pter      End:
62,462,597 bp from pter
Size:
87,579 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZBT46_HUMAN, Q86UZ6 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 46  
Size: 589 amino acids; 64083 Da
Secondary accessions: E1P5K9 Q5JWJ3 Q6GMV4 Q9BQK3 Q9H3Z8 Q9H3Z9

Explore the universe of human proteins at neXtProt for ZBTB46: NX_Q86UZ6

Explore proteomics data for ZBTB46 at MOPED

Post-translational modifications: 

  • Sumoylated. Desumoylation by PPPDE2 reverses transcriptional repression activity (By similarity)1
  • Ubiquitination2 at Lys46
  • Modification sites at PhosphoSitePlus

  • See ZBTB46 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079500.2  
    ENSEMBL proteins: 
     ENSP00000245663   ENSP00000303102   ENSP00000378536  

    ZBTB46 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for ZBTB46 (2 products) 

     
    antibodies-online peptides for ZBTB46

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    antibodies-online antibodies for ZBTB46 (31 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q86UZ6

    ProtoNet protein and cluster: Q86UZ6

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT46_HUMAN, Q86UZ6
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 2 C2H2-type zinc fingers


    Find genes that share domains with ZBTB46           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT46_HUMAN, Q86UZ6
    Function: Function as a transcriptional repressor for PRDM1 (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZBTB46           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB46:
     Decreased viability with pacli 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zbtb46):
     hematopoietic system  immune system 

    Find genes that share phenotypes with ZBTB46           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zbtb46tm2.1Mnz for ZBTB46

       genOway: Develop your customized and physiologically relevant rodent model for ZBTB46

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZBTB46 (see all 85):
    hsa-miR-576-3p hsa-miR-15a hsa-miR-1260b hsa-miR-200a hsa-miR-938 hsa-miR-374a hsa-miR-519a hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidZBTB46 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZBT46_HUMAN, Q86UZ6: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZBTB46           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB46
    Interactions:

        Search GeneGlobe Interaction Network for ZBTB46

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for ZBTB46 (Q86UZ63 ENSP000002456634) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN2Q9Y2T13I2D: score=1 
    NKD1Q969G93I2D: score=1 
    DESI1ENSP000002632564STRING: ENSP00000263256
    SUMO1ENSP000003760764STRING: ENSP00000376076
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0030853negative regulation of granulocyte differentiation IEA--
    GO:0045650negative regulation of macrophage differentiation IEA--
    GO:0045656negative regulation of monocyte differentiation IEA--

    Find genes that share ontologies with ZBTB46           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB46 (ZBT46)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZBTB46 gene: 
    NM_025224.3  

    Unigene Cluster for ZBTB46:

    Zinc finger and BTB domain containing 46
    Hs.585028  [show with all ESTs]
    Unigene Representative Sequence: NM_025224
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245663(uc002ygv.2) ENST00000460757 ENST00000480766 ENST00000302995(uc002ygu.3)
    ENST00000395104
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZBTB46 (see all 85):
    hsa-miR-576-3p hsa-miR-15a hsa-miR-1260b hsa-miR-200a hsa-miR-938 hsa-miR-374a hsa-miR-519a hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidZBTB46 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB46
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZBTB46
      QuantiTect SYBR Green Assays in human, mouse, rat ZBTB46
      QuantiFast Probe-based Assays in human, mouse, rat ZBTB46

    Additional mRNA sequence: 

    AK023564.1 AK126720.1 AK131482.1 

    13 DOTS entries:

    DT.97803346  DT.40255572  DT.100782599  DT.40236365  DT.100782597  DT.100717639  DT.120824915  DT.446689 
    DT.86852840  DT.99957219  DT.99959149  DT.109292  DT.75185917 

    Selected AceView cDNA sequences (see all 86):

    AU136363 BM666831 AI356331 AA575939 AV660389 BU686323 AI290094 AV660466 
    AA653616 BC052269 NM_025224 BX369366 AK023564 AI090891 AL732298 BF058957 
    AW772618 CB269962 AK126720 BQ957018 F04019 BM149515 R40962 BF445912 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB46    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:        -     -     -                       -     -     -                                 
    SP2:                                            -     -     -                                 
    SP3:                                                                                          
    SP4:              -                                                                           


    ECgene alternative splicing isoforms for ZBTB46

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBTB46 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTGCCGT
    ZBTB46 Expression
    About this image


    ZBTB46 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Brain (Nervous System)
             Cerebellum
    ZBTB46 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB46 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585028
        Custom PCR Arrays for ZBTB46
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB46 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb461 , 5 zinc finger and BTB domain containing 461, 5 84.35(n)1
    90.99(a)1
      2 (103.63 cM)5
    721471  NM_027656.21  NP_081932.11 
     1813877625 
    chicken
    (Gallus gallus)
    Aves ZBTB461 zinc finger and BTB domain containing 46 78.69(n)
    80.54(a)
      419259  XM_004947118.1  XP_004947175.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB466
    zinc finger and BTB domain containing 46
    78(a)
    1 ↔ 1
    4(156380654-156449646)
    zebrafish
    (Danio rerio)
    Actinopterygii zbtb461 zinc finger and BTB domain containing 46 70.75(n)
    71.5(a)
      570537  XM_694032.5  XP_699124.5 


    ENSEMBL Gene Tree for ZBTB46 (if available)
    TreeFam Gene Tree for ZBTB46 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBTB46 gene
    ZBTB102  ZBTB32  ZBTB182  ZBTB8A2  ZBTB442  ZBTB52  ENSG000002545532  ZBTB492  
    HIC12  ZBTB482  MYNN2  HIC22  ZBTB422  ZBTB8B2  ZBTB172  
    13 SIMAP similar genes for ZBTB46 using alignment to 1 protein entry:     ZBT46_HUMAN:
    BACH2    DKFZp434J0650    kr-znf3    KLHL32    ZNF55    ZNF
    A-328A3.4    DKFZp547H249    ZNF808    ZBTB10    ZFS-2    ZNF78L1
    DKFZp686N0199

    Find genes that share paralogs with ZBTB46           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZBTB46 (see all 1643)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379092681,2
    --62375959(+) GACATA/GTCTTT 1 -- ut310--------
    rs1420179991,2
    --62376117(+) AAAATC/GCCCCT 1 -- ut310--------
    rs770400741,2
    C--62376130(+) AGCTCC/TGGCGG 1 -- ut312Minor allele frequency- T:0.06CSA WA 120
    rs1889659141,2
    --62376167(+) AGGCCA/CCACGG 1 -- ut310--------
    rs24275371,2
    C,F,A,H--62376227(+) GGGCCC/TGGGTC 1 -- ut31 ese320Minor allele frequency- T:0.47NS EA NA CSA WA 2325
    rs1926241621,2
    --62376263(+) GACTGA/GTACAA 1 -- ut310--------
    rs1130826831,2
    C,F--62376329(+) AAAGTC/TAGTCT 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs60106371,2
    C,F,A,H--62376462(+) ATGCTC/GTCCCC 1 -- ut31 trp34Minor allele frequency- G:0.28NA CSA WA 122
    rs22819251,2
    C,F--62376503(+) TGCTCG/AGTAAG 1 -- ut314Minor allele frequency- A:0.25EA WA NA 1844
    rs1458867111,2
    --62376548(+) TGGCCC/TGGCTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZBTB46 (62375019 - 62462597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZBTB46 (see all 43):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722974CNV Deletion23290073
    esv2722971CNV Deletion23290073
    esv1348867CNV Deletion17803354
    esv2722972CNV Deletion23290073
    esv1000629CNV Deletion20482838
    esv2722959CNV Deletion23290073
    esv4299CNV Deletion18987735
    esv2671555CNV Deletion23128226
    esv2722969CNV Deletion23290073
    esv2722970CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB46
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB46

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614639    OMIM disorders: --


    Find genes that share disorders with ZBTB46           About GenesLikeMe

    Genetic Association Database (GAD): ZBTB46

    Export disorders for ZBTB46 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBTB46 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZBTB46)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    4. MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. (PubMed id 23739915)1  ....Zipp F. (Brain 2013)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. DeSUMOylating isopeptidase: a second class of SUMO protease. (PubMed id 22370726)1 Shin E.J....Yun Y. (EMBO Rep. 2012)
    7. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140685 HGNC: 16094 AceView: BTBD4 Ensembl:ENSG00000130584 euGenes: HUgn140685
    ECgene: ZBTB46 H-InvDB: ZBTB46

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZBTB46 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZBTB46 gene:
    Search GeneIP for patents involving ZBTB46

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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