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Aliases for ZBTB46 Gene

Aliases for ZBTB46 Gene

  • Zinc Finger And BTB Domain Containing 46 2 3
  • BTB-ZF Protein Expressed In Effector Lymphocytes 2 3 4
  • BZEL 3 4 6
  • BTB/POZ Domain-Containing Protein 4 3 4
  • BTB (POZ) Domain Containing 4 2 3
  • Zinc Finger Protein 340 3 4
  • ZNF340 3 4
  • BTBD4 3 4
  • Zinc Finger And BTB Domain-Containing Protein 46 3
  • DJ583P15.7 3
  • DJ583P15.8 3
  • RINZF 3

External Ids for ZBTB46 Gene

Previous Symbols for ZBTB46 Gene

  • ZNF340
  • BTBD4

Summaries for ZBTB46 Gene

GeneCards Summary for ZBTB46 Gene

ZBTB46 (Zinc Finger And BTB Domain Containing 46) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for ZBTB46 Gene

  • Function as a transcriptional repressor for PRDM1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB46 Gene

Genomics for ZBTB46 Gene

Genomic Location for ZBTB46 Gene

Start:
63,743,666 bp from pter
End:
63,832,377 bp from pter
Size:
88,712 bases
Orientation:
Minus strand

Genomic View for ZBTB46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB46 Gene

Regulatory Elements for ZBTB46 Gene

Proteins for ZBTB46 Gene

  • Protein details for ZBTB46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UZ6-ZBT46_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 46
    Protein Accession:
    Q86UZ6
    Secondary Accessions:
    • E1P5K9
    • Q5JWJ3
    • Q6GMV4
    • Q9BQK3
    • Q9H3Z8
    • Q9H3Z9

    Protein attributes for ZBTB46 Gene

    Size:
    589 amino acids
    Molecular mass:
    64083 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB46 Gene

Proteomics data for ZBTB46 Gene at MOPED

Post-translational modifications for ZBTB46 Gene

  • Sumoylated. Desumoylation by PPPDE2 reverses transcriptional repression activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys46

Other Protein References for ZBTB46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB46 Gene

Domains for ZBTB46 Gene

Gene Families for ZBTB46 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

Protein Domains for ZBTB46 Gene

UniProtKB/Swiss-Prot:

ZBT46_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q86UZ6
Similarity:
  • Contains 2 C2H2-type zinc fingers.:
    • Q86UZ6
genes like me logo Genes that share domains with ZBTB46: view

Function for ZBTB46 Gene

Molecular function for ZBTB46 Gene

UniProtKB/Swiss-Prot Function: Function as a transcriptional repressor for PRDM1.

Gene Ontology (GO) - Molecular Function for ZBTB46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB46: view

Phenotypes for ZBTB46 Gene

MGI mutant phenotypes for ZBTB46:
inferred from 3 alleles
GenomeRNAi human phenotypes for ZBTB46:
genes like me logo Genes that share phenotypes with ZBTB46: view

Animal Models for ZBTB46 Gene

MGI Knock Outs for ZBTB46:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZBTB46 Gene

Localization for ZBTB46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB46 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB46 Gene COMPARTMENTS Subcellular localization image for ZBTB46 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB46: view

Pathways for ZBTB46 Gene

SuperPathways for ZBTB46 Gene

No Data Available

Interacting Proteins for ZBTB46 Gene

Gene Ontology (GO) - Biological Process for ZBTB46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030853 negative regulation of granulocyte differentiation IEA --
GO:0045650 negative regulation of macrophage differentiation IEA --
GO:0045656 negative regulation of monocyte differentiation IEA --
genes like me logo Genes that share ontologies with ZBTB46: view

No data available for Pathways by source for ZBTB46 Gene

Transcripts for ZBTB46 Gene

Unigene Clusters for ZBTB46 Gene

Zinc finger and BTB domain containing 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB46 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for ZBTB46 Gene

GeneLoc Exon Structure for
ZBTB46
ECgene alternative splicing isoforms for
ZBTB46

Expression for ZBTB46 Gene

mRNA expression in normal human tissues for ZBTB46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB46 Gene

This gene is overexpressed in Brain - Cerebellum (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZBTB46 Gene

SOURCE GeneReport for Unigene cluster for ZBTB46 Gene Hs.585028

genes like me logo Genes that share expressions with ZBTB46: view

Orthologs for ZBTB46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB46 36
  • 98.98 (n)
  • 98.98 (a)
ZBTB46 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB46 36
  • 86.15 (n)
  • 87.18 (a)
ZBTB46 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC485980 36
  • 87.17 (n)
  • 89.9 (a)
ZBTB46 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb46 36
  • 84.35 (n)
  • 90.99 (a)
Zbtb46 16
Zbtb46 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB46 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB46 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb46 36
  • 84.69 (n)
  • 91.33 (a)
chicken
(Gallus gallus)
Aves ZBTB46 36
  • 78.69 (n)
  • 80.54 (a)
ZBTB46 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB46 37
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zbtb46 36
  • 70.75 (n)
  • 71.5 (a)
zbtb46 37
  • 71 (a)
OneToOne
Species with no ortholog for ZBTB46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB46 Gene

ENSEMBL:
Gene Tree for ZBTB46 (if available)
TreeFam:
Gene Tree for ZBTB46 (if available)

Paralogs for ZBTB46 Gene

Selected SIMAP similar genes for ZBTB46 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB46: view

Variants for ZBTB46 Gene

Sequence variations from dbSNP and Humsavar for ZBTB46 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs747514 -- 63,791,266(-) CACCC(G/T)CCTCG intron-variant
rs755017 -- 63,790,269(+) CTCCC(A/G)GCCAT synonymous-codon, reference, nc-transcript-variant
rs913244 -- 63,826,135(+) AAGAG(C/G)CTTCA intron-variant
rs932824 -- 63,748,962(+) GCTGG(A/G)CCCGG intron-variant
rs932825 -- 63,748,975(+) CCTTA(C/T)GTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB46 Gene

Variant ID Type Subtype PubMed ID
dgv4618n71 CNV Loss 21882294
nsv913190 CNV Loss 21882294
dgv1344e1 CNV Complex 17122850
nsv913213 CNV Loss 21882294
nsv470563 CNV Loss 18288195
dgv4644n71 CNV Loss 21882294
dgv1345e1 CNV Complex 17122850
nsv428381 CNV Gain+Loss 18775914
nsv913241 CNV Loss 21882294
dgv4645n71 CNV Loss 21882294
dgv4647n71 CNV Loss 21882294
nsv913249 CNV Loss 21882294
nsv913250 CNV Loss 21882294
nsv913255 CNV Gain 21882294
esv7227 CNV Loss 19470904
esv2722959 CNV Deletion 23290073
nsv913256 CNV Loss 21882294
dgv4648n71 CNV Loss 21882294
nsv913258 CNV Loss 21882294
dgv4649n71 CNV Loss 21882294
dgv4650n71 CNV Loss 21882294
dgv4651n71 CNV Loss 21882294
dgv523n27 CNV Loss 19166990
nsv913266 CNV Gain 21882294
nsv828802 CNV Loss 20364138
nsv828803 CNV Gain 20364138
esv2722967 CNV Deletion 23290073
esv2722968 CNV Deletion 23290073
nsv459087 CNV Loss 19166990
esv2722969 CNV Deletion 23290073
esv2671555 CNV Deletion 23128226
esv2722970 CNV Deletion 23290073
esv4299 CNV Deletion 18987735
esv1000629 CNV Deletion 20482838
nsv179829 CNV Loss 16902084
nsv180391 CNV Insertion 16902084
esv2722971 CNV Deletion 23290073
esv2722972 CNV Deletion 23290073
esv1348867 CNV Deletion 17803354
esv1008032 CNV Deletion 20482838
nsv179256 CNV Insertion 16902084
nsv913267 CNV Loss 21882294
esv2722974 CNV Deletion 23290073

Relevant External Links for ZBTB46 Gene

HapMap Linkage Disequilibrium report
ZBTB46

Disorders for ZBTB46 Gene

Relevant External Links for ZBTB46

Genetic Association Database (GAD)
ZBTB46
genes like me logo Genes that share disorders with ZBTB46: view

No data available for UniProtKB/Swiss-Prot for ZBTB46 Gene

Publications for ZBTB46 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 49
  4. DeSUMOylating isopeptidase: a second class of SUMO protease. (PMID: 22370726) Shin E.J. … Yun Y. (EMBO Rep. 2012) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for ZBTB46 Gene

Sources for ZBTB46 Gene

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