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ZBTB46 Gene

protein-coding GIFtS: 47

GC20M061845

zinc finger and BTB domain containing 46
(Previous name: BTB (POZ) domain containing 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ZNF340, BTBD4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BTBD4 ^², ³
FLJ13502 ^¹, ²
OTTHUMP00000031601 ^²
RINZF ^¹, ²
ZNF340 ^², ³
dJ583P15.7 ^¹, ²
dJ583P15.8 ^¹, ²

Descriptions
BTB (POZ) domain containing 4 ^¹, ²
BTB/POZ domain-containing protein 4 ^³
Zinc finger protein 340 ^², ³
zinc finger and BTB domain containing 46 ^²

External Ids
HGNC: 16094¹
Entrez Gene: 140685²
UniProtKB: Q86UZ6³
Ensembl: ENSG00000130584⁷

Search outside databases for aliases for ZBTB46 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT46_HUMAN, Q86UZ6

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33

ZBTB46 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M061845: (about GC identifiers)

Start:	61,845,463 bp from pter
End:	61,933,041 bp from pter
Size:	87,579 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011333.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBT46_HUMAN, Q86UZ6 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 46

Size: 589 amino acids; 64083 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: Q5JWJ3 Q6GMV4 Q9BQK3 Q9H3Z8 Q9H3Z9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_079500.1

ENSEMBL proteins:

ENSP00000303102 ENSP00000245663 ENSP00000378536

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZBTB46)
	Human Recombinant Proteins from Abnova (ZBTB46)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

About this table

Antibodies for ZBTB46:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBTB46
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZBTB46), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZBTB46)
	Novus Biologicals Antibodies for ZBTB46

Assays for ZBTB46:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q86UZ6

ProtoNet protein and cluster: Q86UZ6

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: ZBT46_HUMAN, Q86UZ6

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 2 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB46)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB46)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025224

Applied Biosystems Silencer® siRNAs for ZBTB46

Sigma-Aldrich siRNA and siRNA Panels for ZBTB46

Sigma-Aldrich shRNA for ZBTB46

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZBTB46
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_025224
Myc/DDK tagged cDNA clone in CMV expression vector: NM_025224
untagged cDNA clones in CMV expression vector (see all 2): NM_025224

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_025224

UniProtKB/Swiss-Prot: ZBT46_HUMAN, Q86UZ6

Function: May be involved in transcriptional regulation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB46

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB46)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB46)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025224

Sigma-Aldrich siRNA and siRNA Panels for ZBTB46

Sigma-Aldrich shRNA for ZBTB46

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_025224

REFSEQ mRNAs for ZBTB46 gene:

NM_025224.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_025224

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_025224
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_025224
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_025224

Additional cDNA sequence:

AK023564.1 AK126720.1 AK131482.1 BC052269.1 BC073800.1

14 DOTS entries:

DT.97803346 DT.40255572 DT.100782599 DT.40236365 DT.100782597 DT.109292 DT.446689 DT.100717639

DT.120824915 DT.75185917 DT.86852840 DT.99957219 DT.99959149 DT.100038068

24/86 AceView cDNA sequences (see all 86 ):

AI290094 AA653616 AV660389 AA575939 BU686323 AU136363 AV660466 AI356331

BM666831 AV659783 BF445912 BF058957 BX369366 BF724644 AW772618 BX093946

AI827714 AU136677 NM_025224 R40962 BU552629 BQ957018 AK126720 BX339839

highest scoring ESTs for ZBTB46:

AK131482 BC052269 BQ928654 BQ935669 BQ957018 BU542319 BU552629 CD109573 AL731934 AL731935

Unigene Cluster for ZBTB46:

Zinc finger and BTB domain containing 46

Hs.585028 [show with all ESTs]

Unigene Representative Sequence: AK131482

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB46

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b
SP1:			-		-		-								-		-		-
SP2:															-		-		-
SP3:
SP4:					-

About this scheme

ECgene alternative splicing isoforms for ZBTB46

3 Ensembl transcripts including schematic representations:

ENST00000302995 ENST00000245663 ENST00000395104

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB46 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB46

¹ / ² / ³

6 probe-sets matching ZBTB46 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
49704_s_at²^{, 3}	U95-C	1	1.00	1.00	0.95	1.07	AA340768	0.60	0.62	0.61	1
54397_at²^{, 3}	U95-C	1	1.00	1.00	0.86	0.93	AI827714	0.60	0.62	0.61	1
227358_at²^{, 3}	U133-B	1	1.00	1.00	--	--	Z39566	0.40	0.75	0.60	1
227329_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU156821	0.40	0.50	0.45	1
227358_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227329_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZBTB46 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTCTGCCGT

SOURCE GeneReport for Unigene cluster: Hs.585028

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBTB46 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	ZBTB46¹	--	zinc finger and BTB domain containing 46	86.78(n) 88.03(a)	507985 XM_584696.3 XP_584696.3
rat (Rattus norvegicus)	Btbd4¹	--	BTB (POZ) domain containing 4	84.64(n) 91.33(a)	311718 XM_230963.4 XP_230963.3
mouse (Mus musculus)	Zbtb46⁵	2	zinc finger and BTB domain containing 46	--	BG073185
chicken (Gallus gallus)	ZBTB46¹	--	zinc finger and BTB domain containing 46	79.8(n) 82.44(a)	419259 XM_417431.2 XP_417431.2
zebrafish (Danio rerio)	LOC570537¹	--	similar to Zinc finger and BTB domain-containing protein more	70.22(n) 71.2(a)	570537 XM_694032.3 XP_699124.3

About this table Species with no ortholog for ZBTB46

ENSEMBL Gene Tree for ZBTB46

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB46 gene

ZBTB10²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/620 NCBI SNPs in ZBTB46 are shown (see all 620 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 166)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2281929^1,2	A,C,F,H,O	61892524(+)	`GGACGT/CGATTT`	1	A/T	mis¹ ese³		13		EA NA EU WA	2134
--	rs2427537^1,2	A,C,F,H	61846671(+)	`GGGCCC/TGGGTC`	1	--	ut3¹ ese³		8		EU EA WA	824
	rs6010659^1,2	A,F,H	61907466(+)	`GAGACA/GCCTCT`	1	--	ng3¹		4		EU EA WA	418
	rs2296763^1,2	A,C	61847383(+)	`GGAGGA/CGGCCA`	1	--	ut3¹ ese³ trp³		0	--	--	--	--
--	rs4809348^1,2	A,C	61908432(+)	`atggaA/Gtctgg`	1	--	ng3¹		0	--	--	--	--
--	rs4809350^1,2	A,C	61908591(+)	`gttttG/Tttttt`	1	--	ng3¹ trp³		0	--	--	--	--
--	rs6011128^1,2	A,C	61909202(+)	`agtggC/Tgccat`	1	--	ng3¹		0	--	--	--	--
	rs6010637^1,2	A,C	61846906(+)	`ATGCTC/GTCCCC`	1	--	ut3¹ trp³		0	--	--	--	--
	rs11904950^1,2	C,H	61847036(+)	`GCCTCT/ATTCTC`	1	--	ut3¹ trp³		4		EU EA WA	418
--	rs4809349^1,2	A,C	61908586(+)	`ttttgG/Tttttt`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ZBTB46 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for ZBTB46 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
NotI flanking sequences: a tool for gene discovery and verification of the human genome. (PubMed id 12136098)³ Kutsenko A.S....Zabarovsky E.R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 140685	HGNC: 16094	AceView: BTBD4	Ensembl:ENSG00000130584	euGenes: HUgn140685
ECgene: ZBTB46	H-InvDB: ZBTB46

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBTB46
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB46:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB46-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB46		Antibodies for ZBTB46
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBTB46		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ZBTB46)
	Antibodies (ZBTB46)
	Chimera RNAi (ZBTB46)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (ZBTB46)

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Search Tocris compounds for ZBTB46

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ZBTB46

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ZBTB46 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for ZBTB46

Summaries
for ZBTB46

Genomic Location
for ZBTB46

Proteins
for ZBTB46

Protein Domains/
Families
for ZBTB46

Gene Function
for ZBTB46

Pathways & Interactions
for ZBTB46

Drugs & Compounds
for ZBTB46

Transcripts
for ZBTB46

Expression
for ZBTB46

Orthologs
for ZBTB46

Paralogs
for ZBTB46

SNPs/Variants
for ZBTB46

Disorders & Mutations
for ZBTB46

Medical News
for ZBTB46

Publications
for ZBTB46

Search for ZBTB46

Genome Databases showing ZBTB46

Other Databases showing ZBTB46

Specialized Databases showing ZBTB46

Licensable Technologies
for ZBTB46

Services
for ZBTB46

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB46 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor ZBTB46

Summariesfor ZBTB46

Genomic Locationfor ZBTB46

Proteinsfor ZBTB46

Protein Domains/Familiesfor ZBTB46

Gene Functionfor ZBTB46

Pathways & Interactionsfor ZBTB46

Drugs & Compoundsfor ZBTB46

Transcriptsfor ZBTB46

Expression for ZBTB46

Orthologsfor ZBTB46

Paralogsfor ZBTB46

SNPs/Variantsfor ZBTB46

Disorders & Mutationsfor ZBTB46

Medical Newsfor ZBTB46

Publicationsfor ZBTB46

Search for ZBTB46

Genome Databases showing ZBTB46

Other Databases showing ZBTB46

Specialized Databases showing ZBTB46

Licensable Technologiesfor ZBTB46

Servicesfor ZBTB46

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB46

Summaries
for ZBTB46

Genomic Location
for ZBTB46

Proteins
for ZBTB46

Protein Domains/
Families
for ZBTB46

Gene Function
for ZBTB46

Pathways & Interactions
for ZBTB46

Drugs & Compounds
for ZBTB46

Transcripts
for ZBTB46

Expression
for ZBTB46

Orthologs
for ZBTB46

Paralogs
for ZBTB46

SNPs/Variants
for ZBTB46

Disorders & Mutations
for ZBTB46

Medical News
for ZBTB46

Publications
for ZBTB46

Licensable Technologies
for ZBTB46

Services
for ZBTB46