ZBTB45 Gene
protein-coding GIFtS: 45
GCID: GC19M059024
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|
zinc finger and BTB domain containing 45(Previous name: zinc finger protein 499 )
(Previous symbol: ZNF499)
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Aliases
for ZBTB45 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 451 2 | | Zinc Finger Protein 4991 2 3 | | ZNF4991 2 3 | | FLJ144861 | | Zinc Finger And BTB Domain-Containing Protein 452 |
Export aliases for ZBTB45 gene to outside databasesPrevious GC identifers: GC19M063717 GC19M055335 |
Summaries
for ZBTB45 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62Function: May be involved in transcriptional regulation
|
Genomic Views
for ZBTB45 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB45 gene promoter:
COUP-TF1 COUP-TF ARP-1 COUP HNF-4alpha2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB45
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB45 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZBTB45 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M059024: view genomic region
(about GC identifiers)
Start:
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59,024,897 bp from pter |
End:
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59,030,921 bp from pter |
Size:
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6,025 bases |
Orientation:
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minus strand |
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Proteins
for ZBTB45 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 45 Size: 511 amino acids; 54008 Da
Subcellular location: Nucleus (Potential)Explore the universe of human proteins at neXtProt for ZBTB45: NX_Q96K62
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96K62
ZBTB45 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116181.1
ENSEMBL proteins: ENSP00000346603
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZBTB45 for ontologies About GeneDecksing
ZBTB45 Antibody Products:
Assay Products for ZBTB45: |
Protein
Domains /
Families
for ZBTB45 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB45 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96K62ProtoNet protein and cluster: Q96K62 UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 4 C2H2-type zinc fingers |
Function
for ZBTB45 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB45 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB45
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB45 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZBTB45 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZBTB45:
|
Pathways & Interactions
for ZBTB45 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB45
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZBTB45 (Q96K622, 3 ENSP000003466034) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB45 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB45 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB45
Search CenterWatch for drugs/clinical trials and news about ZBTB45 / ZBT45
|
Transcripts
for ZBTB45 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB45 gene: NM_032792.2 Unigene Cluster for ZBTB45: Zinc finger and BTB domain containing 45 Hs.515662 [show with all ESTs]Unigene Representative Sequence: NM_0327921 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000354590(uc002qtd.3 uc002qtf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB45 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB45
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB45 (NM_032792) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB45 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB45 |
Additional cDNA sequence: AK027392.1 AK130056.1 AL831909.1 BC024738.1 7 DOTS entries: DT.97854684 DT.100778524 DT.95252697 DT.92043839 DT.121498820 DT.100721274 DT.121498807 24/117 AceView cDNA sequences (see all 117): BM772046 BM764445 BM771994 BU855190 BM773393 BM772087 AI366079 BM766068 BM771606 BM726403 BM765677 BM766130 BX282081 CR613426 BM783455 BM746985 BM766042 BM766246 BM765537 BI260778 AI479691 AK130056 BM771608 BM765586
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB45 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 |
|---|
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| SP1: | | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZBTB45
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Expression
for ZBTB45 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB45 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCCTAAAC
About this image
See ZBTB45 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB45
SOURCE GeneReport for Unigene cluster: Hs.515662
SABiosciences Custom PCR Arrays for ZBTB45
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB45
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB45 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB45 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB45 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB45 |
Orthologs
for ZBTB45 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB45 gene from 5/10 species (see all 10) About this table
ENSEMBL Gene Tree for ZBTB45 (if available)
TreeFam Gene Tree for ZBTB45 (if available) |
Paralogs
for ZBTB45 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB45 gene
- ZBTB222 ZBTB342 NACC12 ZBTB62 ZBTB92 NACC22 ZBTB432 ZBTB262
- ZBTB122 ZBTB372 ZBTB202
3 SIMAP similar genes for ZBTB45 using alignment to 3 protein entries: ZBT45_HUMAN (see all proteins):DKFZp547H249 ZNF323 ZNF702P
ZBTB45 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZBTB45
PGOHUM00000240247 PGOHUM00000240856
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Genomic Variants
for ZBTB45 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB45 (59024897 - 59030921 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ZBTB45
3 CNVs: 50240 50238 50239 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB45 |
|
Disorders
/ Diseases
for ZBTB45 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZBTB45 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB45 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZBTB45) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZBTB45 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZBTB45 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB45 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB45 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB45 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB45 gene:
Search GeneIP for patents involving ZBTB45
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB45 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZBTB45 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB45 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB45 |
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