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Aliases for ZBTB45 Gene

Aliases for ZBTB45 Gene

  • Zinc Finger And BTB Domain Containing 45 2 3 5
  • Zinc Finger Protein 499 2 3 4
  • ZNF499 3 4
  • Zinc Finger And BTB Domain-Containing Protein 45 3

External Ids for ZBTB45 Gene

Previous HGNC Symbols for ZBTB45 Gene

  • ZNF499

Previous GeneCards Identifiers for ZBTB45 Gene

  • GC19M063717
  • GC19M059024
  • GC19M055335

Summaries for ZBTB45 Gene

GeneCards Summary for ZBTB45 Gene

ZBTB45 (Zinc Finger And BTB Domain Containing 45) is a Protein Coding gene. An important paralog of this gene is ZBTB20.

UniProtKB/Swiss-Prot for ZBTB45 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB45 Gene

Genomics for ZBTB45 Gene

Regulatory Elements for ZBTB45 Gene

Enhancers for ZBTB45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G058517 2.1 FANTOM5 Ensembl ENCODE dbSUPER 20.9 +19.2 19203 4.9 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF324B ZNF549 CENPBD1P1 MZF1 ZNF134 ZNF606 LOC100128398 ZNF324 ZBTB45 ZNF418
GH19G058498 1.4 ENCODE dbSUPER 13.1 +39.7 39747 2.2 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF584 ZBTB45 ZNF324B CENPBD1P1 A1BG LOC105372485 GC19M058491
GH19G058571 1.4 ENCODE dbSUPER 12.3 -35.2 -35202 4.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZSCAN18 LOC100128398 TRIM28 ZNF418 ENSG00000268201 LOC105372482 ZNF606 LOC105372483 MZF1 ENSG00000268049
GH19G057809 1.7 FANTOM5 ENCODE dbSUPER 9.7 +725.7 725694 7.2 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF264 TRIM28 ZNF17 ZNF417 ZNF256 ZNF543 ZNF805 ZNF606 ZNF773
GH19G058304 1.2 ENCODE 12.7 +233.4 233385 2.3 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 ZNF324B ERVK3-1 ZNF549 ZNF17 ZBTB45 ZNF606 MZF1 ZNF544 LOC100506634 ZNF324
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB45 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111888 311 401 SOX13 RBBP5 HBP1 POLR2A NR2F6 SOX5 RNF2 SP5 BHLHE40 NR2F1

Genomic Location for ZBTB45 Gene

Chromosome:
19
Start:
58,513,530 bp from pter
End:
58,538,911 bp from pter
Size:
25,382 bases
Orientation:
Minus strand

Genomic View for ZBTB45 Gene

Genes around ZBTB45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB45 Gene

Proteins for ZBTB45 Gene

  • Protein details for ZBTB45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K62-ZBT45_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 45
    Protein Accession:
    Q96K62

    Protein attributes for ZBTB45 Gene

    Size:
    511 amino acids
    Molecular mass:
    54008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB45 Gene

Post-translational modifications for ZBTB45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB45 Gene

Domains & Families for ZBTB45 Gene

Gene Families for ZBTB45 Gene

Protein Domains for ZBTB45 Gene

Suggested Antigen Peptide Sequences for ZBTB45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96K62

UniProtKB/Swiss-Prot:

ZBT45_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB45: view

Function for ZBTB45 Gene

Molecular function for ZBTB45 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB45: view
genes like me logo Genes that share phenotypes with ZBTB45: view

Animal Models for ZBTB45 Gene

MGI Knock Outs for ZBTB45:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB45 Gene

Localization for ZBTB45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB45 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZBTB45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB45: view

Pathways & Interactions for ZBTB45 Gene

SuperPathways for ZBTB45 Gene

No Data Available

Interacting Proteins for ZBTB45 Gene

Gene Ontology (GO) - Biological Process for ZBTB45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with ZBTB45: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB45 Gene

Drugs & Compounds for ZBTB45 Gene

No Compound Related Data Available

Transcripts for ZBTB45 Gene

Unigene Clusters for ZBTB45 Gene

Zinc finger and BTB domain containing 45:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB45 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4
SP1: - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for ZBTB45 Gene

GeneLoc Exon Structure for
ZBTB45
ECgene alternative splicing isoforms for
ZBTB45

Expression for ZBTB45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB45 Gene

Protein differential expression in normal tissues from HIPED for ZBTB45 Gene

This gene is overexpressed in Kidney (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB45 Gene



Protein tissue co-expression partners for ZBTB45 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB45 Gene:

ZBTB45

SOURCE GeneReport for Unigene cluster for ZBTB45 Gene:

Hs.515662

Evidence on tissue expression from TISSUES for ZBTB45 Gene

  • Stomach(3.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ZBTB45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB45 Gene

Orthologs for ZBTB45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB45 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia ZBTB45 34 35
  • 81.96 (n)
cow
(Bos Taurus)
Mammalia ZBTB45 34
  • 81.72 (n)
mouse
(Mus musculus)
Mammalia Zbtb45 34 16 35
  • 80.5 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb45 34
  • 79.91 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB45 35
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485837 34
  • 57.45 (n)
Str.14835 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19474 34
Species where no ortholog for ZBTB45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZBTB45 Gene

ENSEMBL:
Gene Tree for ZBTB45 (if available)
TreeFam:
Gene Tree for ZBTB45 (if available)

Paralogs for ZBTB45 Gene

Pseudogenes.org Pseudogenes for ZBTB45 Gene

genes like me logo Genes that share paralogs with ZBTB45: view

Variants for ZBTB45 Gene

Sequence variations from dbSNP and Humsavar for ZBTB45 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000009784 -- 58,527,218(+) CCACC(C/G)ACAGT intron-variant
rs1000064811 -- 58,526,962(+) AGCTG(C/G)GACTA intron-variant
rs1000091034 -- 58,513,695(+) GCAGG(C/G)AAGCG upstream-variant-2KB, utr-variant-3-prime
rs1000121357 -- 58,531,596(+) GGCCA(C/T)GTGTT intron-variant
rs1000130008 -- 58,521,018(+) CTGCA(C/T)TCCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZBTB45 Gene

Variant ID Type Subtype PubMed ID
dgv3687n100 CNV gain 25217958
dgv3688n100 CNV gain 25217958
nsv1057077 CNV gain 25217958
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv828657 CNV gain 20364138
nsv952156 CNV deletion 24416366

Variation tolerance for ZBTB45 Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB45 Gene

Human Gene Mutation Database (HGMD)
ZBTB45
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB45 Gene

Disorders for ZBTB45 Gene

Relevant External Links for ZBTB45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB45

No disorders were found for ZBTB45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB45 Gene

Publications for ZBTB45 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier R.A. … Vermeulen M. (J. Biol. Chem. 2016) 3 64
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZBTB45 Gene

Sources for ZBTB45 Gene

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