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ZBTB45 Gene

protein-coding   GIFtS: 45
GCID: GC19M059024

Zinc Finger And BTB Domain Containing 45

(Previous name: zinc finger protein 499)
(Previous symbol: ZNF499)
  Search for ZBTB45
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 451 2
Zinc Finger Protein 4991 2 3
ZNF4991 2 3
Zinc Finger And BTB Domain-Containing Protein 452

External Ids:    HGNC: 237151   Entrez Gene: 848782   Ensembl: ENSG000001195747   UniProtKB: Q96K623   

Export aliases for ZBTB45 gene to outside databases

Previous GC identifers: GC19M063717 GC19M055335


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZBTB45 Gene:
ZBTB45 (zinc finger and BTB domain containing 45) is a protein-coding gene. An important paralog of this gene is ZBTB34.

UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB45 gene promoter:
         COUP-TF1   COUP-TF   ARP-1   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB45 promoter sequence
   Search Chromatin IP Primers for ZBTB45

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZBTB45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB45 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M059024:  view genomic region     (about GC identifiers)

Start:
59,024,897 bp from pter      End:
59,050,278 bp from pter
Size:
25,382 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 45  
Size: 511 amino acids; 54008 Da

Explore the universe of human proteins at neXtProt for ZBTB45: NX_Q96K62

Explore proteomics data for ZBTB45 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZBTB45 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116181.1  
    ENSEMBL proteins: 
     ENSP00000346603   ENSP00000469089   ENSP00000473072   ENSP00000470316   ENSP00000471885  

    ZBTB45 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for ZBTB45

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    Search eBioscience for ELISAs for ZBTB45 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q96K62

    ProtoNet protein and cluster: Q96K62

    UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 4 C2H2-type zinc fingers


    Find genes that share domains with ZBTB45           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT45_HUMAN, Q96K62
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZBTB45           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZBTB45:
     Decreased Wnt reporter activit  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZBTB45
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBTB45
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZBTB45

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZBTB45:
    hsa-mir-484 (MIRT041924)

    Block miRNA regulation of human, mouse, rat ZBTB45 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZBTB45:
    hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidZBTB45 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZBTB45

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    GenScript: all cDNA clones in your preferred vector: ZBTB45 (NM_032792)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB45
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB45

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB45


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZBT45_HUMAN, Q96K62: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZBTB45           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB45
    Interactions:

        Search GeneGlobe Interaction Network for ZBTB45

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZBTB45 (Q96K622, 3 ENSP000003466034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED31Q9Y3C72, 3, ENSP000002257284MINT-65223 I2D: score=5 STRING: ENSP00000225728
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZBTB45           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB45 (ZBT45)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZBTB45 gene: 
    NM_032792.2  

    Unigene Cluster for ZBTB45:

    Zinc finger and BTB domain containing 45
    Hs.515662  [show with all ESTs]
    Unigene Representative Sequence: NM_032792
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354590(uc002qtd.3 uc002qtf.3) ENST00000594051 ENST00000600990
    ENST00000600130 ENST00000596739
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZBTB45 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZBTB45:
    hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidZBTB45 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZBTB45
    Predesigned siRNA for gene silencing in human, mouse, rat ZBTB45
    Clone
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    OriGene clones in human, mouse for ZBTB45 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: ZBTB45 (NM_032792)
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    Primer
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    OriGene qPCR primer pairs and template standards for ZBTB45
    OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB45
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZBTB45
      QuantiTect SYBR Green Assays in human, mouse, rat ZBTB45
      QuantiFast Probe-based Assays in human, mouse, rat ZBTB45

    Additional mRNA sequence: 

    AK027392.1 AK130056.1 AL831909.1 BC024738.1 

    7 DOTS entries:

    DT.97854684  DT.100778524  DT.95252697  DT.92043839  DT.121498820  DT.100721274  DT.121498807 

    Selected AceView cDNA sequences (see all 117):

    BM765677 BM783476 BM764445 BM765600 BM771994 BM765992 AI479691 BI260778 
    CD672246 BM771608 BU855190 BM765282 BM783455 BM772046 BM771646 BM772087 
    BM766079 BM766130 BM766042 BM766027 BM765537 AI366079 BM765586 BM766246 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB45    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4
    SP1:              -     -     -                           
    SP2:                          -                           
    SP3:                    -     -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for ZBTB45

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBTB45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCTAAAC
    ZBTB45 Expression
    About this image

    ZBTB45 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB45 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515662
        Custom PCR Arrays for ZBTB45
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB45 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb451 , 5 zinc finger and BTB domain containing 451, 5 80.5(n)1
    86.69(a)1
      7 (7.72 cM)5
    2328791  NM_001024699.11  NP_001019870.11 
     130056665 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB456
    zinc finger and BTB domain containing 45
    39(a)
    1 ↔ 1
    GL343253.1(38475-45019)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.194742 Xenopus laevis transcribed sequence with weak similarity more 84.07(n)    BQ386060.1 


    ENSEMBL Gene Tree for ZBTB45 (if available)
    TreeFam Gene Tree for ZBTB45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBTB45 gene
    ZBTB342  ZBTB222  NACC12  ZBTB62  ZBTB92  NACC22  ZBTB122  ZBTB262  
    ZBTB432  ZBTB372  ZBTB202  
    Selected SIMAP similar genes for ZBTB45 using alignment to 3 protein entries:     ZBT45_HUMAN (see all proteins) (see all similar genes):
    DKFZp547H249    ZBTB22    ZBTB4    ZBTB43    NACC1    ZBTB20
    ZNF323    ZBTB38    ZBTB14    KLHL28    KLHL18    ZBTB25
    HIC1    KEAP1    ZBTB16    KLHL32    ZBTB44    KLHL2

    Find genes that share paralogs with ZBTB45           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZBTB45
    PGOHUM00000240247 PGOHUM00000240856


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZBTB45 (see all 174)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1513043911,2
    C,F--59025532(+) TGCACG/ATTGAG 2 /N syn11Minor allele frequency- A:0.00NA 3490
    rs2001562581,2
    --59025544(+) GAGCTC/TTTCTG 2 K syn10--------
    rs1859844011,2
    C--59025628(+) TAGTCC/GCGTAG 2 R syn10--------
    rs2017956181,2
    --59025640(+) GAGAAC/GGATCG 2 S syn10--------
    rs48016021,2
    C,F,H--59025685(+) GCGGAC/AGACAG 1 -- int112Minor allele frequency- A:0.10NS EA NA CSA WA EU 995
    rs2015918471,2
    --59025727(+) GCTCCC/TCGCCC 1 -- int10--------
    rs755969821,2
    C,F--59025837(+) CCCCTC/TACTAT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1920711551,2
    --59025919(+) AACAGA/GGATCC 1 -- int10--------
    rs1823571891,2
    --59025951(+) TCTCCA/CATCCC 1 -- int10--------
    rs1142646131,2
    F--59026097(+) ATCTCC/TCTCTA 1 -- int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for ZBTB45 (59024897 - 59050278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZBTB45:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912546CNV Loss21882294
    nsv828657CNV Gain20364138
    nsv515731CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB45
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB45

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBTB45 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZBTB45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84878 HGNC: 23715 AceView: ZNF499 Ensembl:ENSG00000119574 euGenes: HUgn84878
    ECgene: ZBTB45 H-InvDB: ZBTB45

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZBTB45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZBTB45 gene:
    Search GeneIP for patents involving ZBTB45

    GeneCards and IP:
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