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ZBTB45 Gene

protein-coding GIFtS: 46

GC19M063717

zinc finger and BTB domain containing 45
(Previous name: zinc finger protein 499 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF499)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp547H249 ^²
FLJ14486 ^¹, ²
ZNF499 ^², ³

Descriptions
Zinc finger protein 499 ^¹, ², ³
zinc finger and BTB domain containing 45 ^²

External Ids
HGNC: 23715¹
Entrez Gene: 84878²
UniProtKB: Q96K62³
Ensembl: ENSG00000119574⁷

Search outside databases for aliases for ZBTB45 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43

ZBTB45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M063717: (about GC identifiers)

Start:	63,716,709 bp from pter
End:	63,722,733 bp from pter
Size:	6,025 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 45

Size: 511 amino acids; 54008 Da

Subcellular location: Nucleus (Potential)

REFSEQ proteins: NP_116181.1

ENSEMBL proteins:

ENSP00000346603

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZNF499)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

About this table

Antibodies for ZBTB45:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBTB45
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZNF499), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZBTB45

Assays for ZBTB45:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96K62

ProtoNet protein and cluster: Q96K62

UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 4 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB45)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZNF499)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032792

Applied Biosystems Silencer® siRNAs for ZBTB45

Sigma-Aldrich siRNA and siRNA Panels for ZBTB45

Sigma-Aldrich shRNA for ZBTB45

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_032792
Myc/DDK tagged cDNA clone in CMV expression vector: NM_032792
untagged cDNA clone in CMV expression vector: NM_032792

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032792

UniProtKB/Swiss-Prot: ZBT45_HUMAN, Q96K62

Function: May be involved in transcriptional regulation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for ZBTB45 (Q96K62²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
MED31 Q9Y3C7² MINT-65223
About this table
2 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006350 transcription IEA --
GO:0006355 regulation of transcription, DNA-dependent IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB45

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB45)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZNF499)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032792

Sigma-Aldrich siRNA and siRNA Panels for ZBTB45

Sigma-Aldrich shRNA for ZBTB45

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032792

REFSEQ mRNAs for ZBTB45 gene:

NM_032792.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032792

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032792
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032792
                                 untagged cDNA clone in CMV expression vector: NM_032792

Additional cDNA sequence:

AK027392.1 AK130056.1 AL831909.1 BC024738.1 CR613426.1

7 DOTS entries:

DT.97854684 DT.100778524 DT.95252697 DT.92043839 DT.121498820 DT.100721274 DT.121498807

24/117 AceView cDNA sequences (see all 117 ):

AL831909 BM765600 BM771994 BM766130 BM771646 BM771606 BM765537 BM773393

BM766042 BM784352 AI366079 AI479691 BM772087 BX282081 BM783455 BM783476

BM772070 BM773391 AI858963 BI260778 BM766068 BM765992 CR613426 BC024738

highest scoring ESTs for ZBTB45:

AK027392 BC024738 BI260778 BM552920 BM562296 BM809419 BQ707310 BX464507 CB153932 W63776

Unigene Cluster for ZBTB45:

Zinc finger and BTB domain containing 45

Hs.515662 [show with all ESTs]

Unigene Representative Sequence: NM_032792

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB45

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	·	3c	^	4
SP1:					-		-		-
SP2:									-
SP3:							-		-
SP4:

About this scheme

ECgene alternative splicing isoforms for ZBTB45

1 Ensembl transcript including schematic representation:

ENST00000354590

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB45 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB45

¹ / ² / ³

6 probe-sets matching ZBTB45 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54400_at²^{, 3}	U95-B	1	0.94	1.00	0.82	0.89	W63776	0.80	1.00	0.91	1
55301_at²^{, 3}	U95-C	1	0.94	1.00	0.85	1.11	AI634118	0.40	1.00	0.76	1
229862_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	W63776	0.80	1.00	0.91	1
240551_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE550601	0.20	1.00	0.72	1
229862_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
240551_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGGCCTAAAC

SOURCE GeneReport for Unigene cluster: Hs.515662

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBTB45 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBTB45¹	--	zinc finger and BTB domain containing 45	82.35(n) 88.82(a)	484222 XM_541338.2 XP_541338.2
cow (Bos taurus)	ZBTB45¹	--	zinc finger and BTB domain containing 45	81.72(n) 84.14(a)	506887 XM_583399.3 XP_583399.3
rat (Rattus norvegicus)	Zbtb45¹	--	zinc finger and BTB domain containing 45	80.76(n) 88.26(a)	308366 XM_238764.4 XP_238764.2
mouse (Mus musculus)	Zbtb45^{1, 5}	7⁵	zinc finger and BTB domain containing 45^{1, 5}	81.41(n)¹ 88.26(a)¹	232879¹ NM_001024699.1¹ NP_001019870.1¹ AI595382⁵ AK154877⁵ (see all 10)
African clawed frog (Xenopus laevis)	Xl.19474²	--	Xenopus laevis transcribed sequence with weak similarity more	84.07(n)	BQ386060.1

About this table Species with no ortholog for ZBTB45

ENSEMBL Gene Tree for ZBTB45

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB45 gene

NACC1² NACC2² ZBTB20²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/25 NCBI SNPs in ZBTB45 are shown (see all 25 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 12)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs35430780^1,2	C,F	63719974(+)	`TCCTCG/CTCGTG`	1	E/D	mis¹		5		NA EU EA WA	490
	rs4801276^1,2	C,H	63723285(+)	`CAAGTC/GCCCAA`	1	--	ng3¹		4		EU EA WA	418
	rs11670864^1,2	C,F,H	63722392(+)	`CCTGTG/TCCCGC`	1	--	int¹		8		EU EA WA	838
	rs4801602^1,2	C,F,H	63717497(+)	`GCGGAC/AGACAG`	1	--	int¹		4		EU EA WA	414
	rs13345233^1,2	F,H	63721118(+)	`TAGGAA/GAGGGT`	1	--	int¹		4		EU EA WA	416
--	rs35591276^1,2	--	63720179(+)	`CGCCA-/CCTTCG`	1	G/	fra¹		0	--	--	--	--
--	rs61735231^1,2	--	63720505(+)	`CATTCC/TTCGAT`	2	D/E	mis¹		0	--	--	--	--
--	rs34757452^1,2	--	63719826(+)	`GGTGC-/GGGGTG`	1	P/P	fra¹		0	--	--	--	--
--	rs73066241^1,2	--	63724568(+)	`AGAAAA/GAAAGA`	1	--	ng3¹		0	--	--	--	--
--	rs73066242^1,2	--	63724606(+)	`TGCGTA/GGAGCT`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ZBTB45 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for ZBTB45 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 84878	HGNC: 23715	AceView: ZNF499	Ensembl:ENSG00000119574	euGenes: HUgn84878
ECgene: ZBTB45	H-InvDB: ZBTB45

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBTB45
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB45:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB45-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB45		Antibodies for ZBTB45
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBTB45		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for ZBTB45

Search Tocris compounds for ZBTB45

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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ZBTB45 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for ZBTB45

Summaries
for ZBTB45

Genomic Location
for ZBTB45

Proteins
for ZBTB45

Protein Domains/
Families
for ZBTB45

Gene Function
for ZBTB45

Pathways & Interactions
for ZBTB45

Drugs & Compounds
for ZBTB45

Transcripts
for ZBTB45

Expression
for ZBTB45

Orthologs
for ZBTB45

Paralogs
for ZBTB45

SNPs/Variants
for ZBTB45

Disorders & Mutations
for ZBTB45

Medical News
for ZBTB45

Publications
for ZBTB45

Search for ZBTB45

Genome Databases showing ZBTB45

Other Databases showing ZBTB45

Specialized Databases showing ZBTB45

Licensable Technologies
for ZBTB45

Services
for ZBTB45

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB45 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor ZBTB45

Summariesfor ZBTB45

Genomic Locationfor ZBTB45

Proteinsfor ZBTB45

Protein Domains/Familiesfor ZBTB45

Gene Functionfor ZBTB45

Pathways & Interactionsfor ZBTB45

Drugs & Compoundsfor ZBTB45

Transcriptsfor ZBTB45

Expression for ZBTB45

Orthologsfor ZBTB45

Paralogsfor ZBTB45

SNPs/Variantsfor ZBTB45

Disorders & Mutationsfor ZBTB45

Medical Newsfor ZBTB45

Publicationsfor ZBTB45

Search for ZBTB45

Genome Databases showing ZBTB45

Other Databases showing ZBTB45

Specialized Databases showing ZBTB45

Licensable Technologiesfor ZBTB45

Servicesfor ZBTB45

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB45

Summaries
for ZBTB45

Genomic Location
for ZBTB45

Proteins
for ZBTB45

Protein Domains/
Families
for ZBTB45

Gene Function
for ZBTB45

Pathways & Interactions
for ZBTB45

Drugs & Compounds
for ZBTB45

Transcripts
for ZBTB45

Expression
for ZBTB45

Orthologs
for ZBTB45

Paralogs
for ZBTB45

SNPs/Variants
for ZBTB45

Disorders & Mutations
for ZBTB45

Medical News
for ZBTB45

Publications
for ZBTB45

Licensable Technologies
for ZBTB45

Services
for ZBTB45