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Aliases for ZBTB44 Gene

Aliases for ZBTB44 Gene

  • Zinc Finger And BTB Domain Containing 44 2 3 5
  • BTB/POZ Domain-Containing Protein 15 3 4
  • BTB (POZ) Domain Containing 15 2 3
  • Zinc Finger Protein 851 3 4
  • BTBD15 3 4
  • ZNF851 3 4
  • Zinc Finger And BTB Domain-Containing Protein 44 3
  • HSPC063 3

External Ids for ZBTB44 Gene

Previous HGNC Symbols for ZBTB44 Gene

  • BTBD15

Previous GeneCards Identifiers for ZBTB44 Gene

  • GC11M129603
  • GC11M130096
  • GC11M126049

Summaries for ZBTB44 Gene

GeneCards Summary for ZBTB44 Gene

ZBTB44 (Zinc Finger And BTB Domain Containing 44) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBTB10.

UniProtKB/Swiss-Prot for ZBTB44 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB44 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB44 Gene

Genomics for ZBTB44 Gene

Regulatory Elements for ZBTB44 Gene

Enhancers for ZBTB44 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H130915 1 ENCODE 10.4 -601.4 -601380 2 ATF1 SIN3A ZNF2 YY1 ETS1 ZNF766 CBX5 ELK1 ZNF207 ZNF143 SNX19 ZBTB44 PRDM10 GC11M130915
GH11H130191 1 ENCODE dbSUPER 6.3 +121.9 121855 2.4 TBP ARID4B CEBPG ZNF384 RARA HNF4G NR2F6 MIXL1 GATAD2A CEBPB ZBTB44 ST14 GC11P130253
GH11H130312 1 ENCODE 5.7 +0.1 75 3.8 SIN3A YY1 GLIS2 ZNF143 ATF7 RUNX3 SP3 SP5 REST SMARCB1 ZBTB44 RN7SL778P
GH11H130220 0.5 ENCODE 6.6 +93.8 93826 0.9 POLR2A CEBPA HLF ADAMTS8 ZBTB44 GC11P130253 ST14
GH11H130294 0.4 ENCODE 7.8 +18.8 18792 2 TAL1 ATF2 ZBTB44 DDX18P5 RN7SL778P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB44 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047087 369 2401 SIN3A YY1 GLIS2 ZNF143 ATF7 RUNX3 SP5 REST SMARCB1 MEF2D

Genomic Locations for ZBTB44 Gene

Genomic Locations for ZBTB44 Gene
chr11:130,226,677-130,314,769
(GRCh38/hg38)
Size:
88,093 bases
Orientation:
Minus strand
chr11:130,096,572-130,184,607
(GRCh37/hg19)

Genomic View for ZBTB44 Gene

Genes around ZBTB44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB44 Gene

Proteins for ZBTB44 Gene

  • Protein details for ZBTB44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCP5-ZBT44_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 44
    Protein Accession:
    Q8NCP5
    Secondary Accessions:
    • Q6IPT8
    • Q86VJ7
    • Q86XX5

    Protein attributes for ZBTB44 Gene

    Size:
    570 amino acids
    Molecular mass:
    63848 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB44 Gene

Post-translational modifications for ZBTB44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB44 Gene

Domains & Families for ZBTB44 Gene

Gene Families for ZBTB44 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB44 Gene

Suggested Antigen Peptide Sequences for ZBTB44 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB44: view

No data available for UniProtKB/Swiss-Prot for ZBTB44 Gene

Function for ZBTB44 Gene

Molecular function for ZBTB44 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB44: view

Phenotypes for ZBTB44 Gene

genes like me logo Genes that share phenotypes with ZBTB44: view

Animal Model Products

CRISPR Products

miRNA for ZBTB44 Gene

miRTarBase miRNAs that target ZBTB44

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB44 Gene

Localization for ZBTB44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB44 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB44 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB44: view

Pathways & Interactions for ZBTB44 Gene

SuperPathways for ZBTB44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB44: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB44 Gene

Drugs & Compounds for ZBTB44 Gene

No Compound Related Data Available

Transcripts for ZBTB44 Gene

Unigene Clusters for ZBTB44 Gene

Zinc finger and BTB domain containing 44:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB44 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - -
SP8:
SP9: -

Relevant External Links for ZBTB44 Gene

GeneLoc Exon Structure for
ZBTB44
ECgene alternative splicing isoforms for
ZBTB44

Expression for ZBTB44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB44 Gene

Protein differential expression in normal tissues from HIPED for ZBTB44 Gene

This gene is overexpressed in Plasma (45.3) and Peripheral blood mononuclear cells (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB44 Gene



Protein tissue co-expression partners for ZBTB44 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB44 Gene:

ZBTB44

SOURCE GeneReport for Unigene cluster for ZBTB44 Gene:

Hs.721470

Evidence on tissue expression from TISSUES for ZBTB44 Gene

  • Nervous system(4.6)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZBTB44: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB44 Gene

Orthologs for ZBTB44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB44 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia ZBTB44 33 34
  • 94.22 (n)
cow
(Bos Taurus)
Mammalia ZBTB44 33 34
  • 93.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB44 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb44 33 16 34
  • 91.83 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb44 33
  • 91.39 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
OneToMany
-- 34
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZBTB44 33 34
  • 83.48 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB44 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb44 33
  • 77.9 (n)
Str.16848 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15152 33
zebrafish
(Danio rerio)
Actinopterygii zbtb44 33 34
  • 65.08 (n)
Species where no ortholog for ZBTB44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB44 Gene

ENSEMBL:
Gene Tree for ZBTB44 (if available)
TreeFam:
Gene Tree for ZBTB44 (if available)

Paralogs for ZBTB44 Gene

Variants for ZBTB44 Gene

Sequence variations from dbSNP and Humsavar for ZBTB44 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000011780 -- 130,303,041(+) AAAAC(G/T)TATTC intron-variant
rs1000015652 -- 130,266,536(+) AAAGC(A/G)AAGTG intron-variant
rs1000027205 -- 130,282,642(+) CCCTA(C/G)AGCCT intron-variant
rs1000083558 -- 130,248,752(+) TATAT(A/G)GGTAA intron-variant
rs1000148684 -- 130,299,188(+) AAGAA(A/G)GATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB44 Gene

Variant ID Type Subtype PubMed ID
nsv975998 CNV duplication 23825009
nsv832295 CNV gain 17160897
nsv818872 CNV loss 17921354
nsv556571 CNV loss 21841781
nsv468896 CNV loss 19166990
nsv39016 CNV deletion 16902084
nsv1070496 CNV deletion 25765185
esv3628079 CNV loss 21293372
esv3628078 CNV loss 21293372
esv34550 CNV loss 17911159
esv33203 CNV loss 17666407
esv2759871 CNV loss 17122850
dgv74e215 CNV deletion 23714750

Variation tolerance for ZBTB44 Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB44 Gene

Disorders for ZBTB44 Gene

Relevant External Links for ZBTB44

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB44

No disorders were found for ZBTB44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB44 Gene

Publications for ZBTB44 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for ZBTB44 Gene

Sources for ZBTB44 Gene

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