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ZBTB44 Gene

protein-coding   GIFtS: 46

GC11M129603
zinc finger and BTB domain containing 44
(Previous name: BTB (POZ) domain containing 15 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BTBD15)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
BTBD15 2, 3
HSPC063 1, 2
MGC26123 2
MGC57431 2
MGC60348 2
MGC88058 2
ZNF851 1, 2
Descriptions
BTB (POZ) domain containing 15 1, 2
BTB/POZ domain-containing protein 15 3
zinc finger and BTB domain containing 44 2
External Ids
HGNC: 250011
Entrez Gene: 290682
UniProtKB: Q8NCP53
Ensembl: ENSG000001963237
Search outside databases for aliases for ZBTB44 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT44_HUMAN, Q8NCP5
Function: May be involved in transcriptional regulation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.3   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24.3

ZBTB44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M129603:     (about GC identifiers)

Start:
129,597,423 bp from pter
End:
129,689,817 bp from pter
Size:
92,395 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000011.8  NT_033899.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT44_HUMAN, Q8NCP5 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 44  
Size: 570 amino acids; 63848 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q6IPT8 Q86VJ7 Q86XX5
Alternative splicing: 4 isoforms:  Q8NCP5-1   Q8NCP5-2   Q8NCP5-3   Q8NCP5-4   

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_054874.3  

    ENSEMBL proteins: 
    ENSP00000350574 ENSP00000341618 ENSP00000380861 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BTBD15)
    Human Recombinant Proteins from Abnova (BTBD15)
                  OriGene Purified Recombinant Human Protein: ZBTB44 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZBTB44: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZBTB44
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (BTBD15), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (BTBD15)
    Novus Biologicals Antibody for ZBTB44

    Assays for ZBTB44: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ


       GeneDecks  ZBTB44 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8NCP5

    ProtoNet protein and cluster: Q8NCP5

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT44_HUMAN, Q8NCP5
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 4 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB44)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BTBD15)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014155

                  Applied Biosystems Silencer® siRNAs for ZBTB44

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB44  
                         Sigma-Aldrich shRNA for ZBTB44  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ZBTB44
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014155
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014155
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_014155 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_014155

    UniProtKB/Swiss-Prot: ZBT44_HUMAN, Q8NCP5
    Function: May be involved in transcriptional regulation (By similarity)

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB44

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB44)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BTBD15)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014155

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB44  
                         Sigma-Aldrich shRNA for ZBTB44  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_014155  

    REFSEQ mRNAs for ZBTB44 gene: 

    NM_014155.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_014155  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014155
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014155
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_014155 

    Additional cDNA sequence: 

    AF161548.1 AK023933.1 AK024659.1 AK026770.1 AK096676.1 AK130071.1 AK314701.1 BC017675.2 
    BC040658.1 BC071729.1 CR615509.1 

    13 DOTS entries:

    DT.453369  DT.100646532  DT.95328396  DT.100748982  DT.115092  DT.92070124  DT.40127822  DT.91699219 
    DT.95270526  DT.120736652  DT.120779902  DT.102844137  DT.40131694 

    24/270 AceView cDNA sequences (see all 270 ):

    BM969910 AA480979 CD642602 AA931090 AU141844 BQ953305 T16371 BG565590 
    BQ130575 CA391236 AA765505 AI807684 AK024659 CK821904 BC017675 AA480980 
    AA352857 BM718607 AI245892 AA723924 AI989464 AI866261 AK023933 AA286906 

    highest scoring ESTs for ZBTB44:

    AA521091 AI927695 AF150253 AF161548 AL707880 BC071729 BG723160 BI459825 BI460291 BI520347 

    Unigene Cluster for ZBTB44:

    Zinc finger and BTB domain containing 44
    Hs.719099  [show with all ESTs]
    Unigene Representative Sequence: NM_014155


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB44 (see all 9 )

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                                            -                             -                 -           -     -               
    SP2:                                            -                                   -           -           -     -               
    SP3:                                            -                             -     -                                             
    SP4:                                            -                             -     -     -     -           -     -               
    SP5:                                            -                             -     -     -     -                                 

    About this scheme

    ECgene alternative splicing isoforms for ZBTB44

    3 Ensembl transcripts including schematic representations:
    ENST00000357899  ENST00000338191  ENST00000397753  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB44 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB44

    1 / 2 / 3

    11 probe-sets matching ZBTB44 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    53114_at2, 3 U95-B 1 1.00 1.00 0.73 0.76 AI927695 0.80 1.00 0.91 1

    43371_s_at2, 3 U95-B 1 1.00 1.00 0.91 1.30 AI983688 0.60 1.00 0.82 1

    49531_at2, 3 U95-B 1 1.00 1.00 0.88 1.32 AI890488 0.60 1.00 0.82 1
    47997_at2, 3 U95-B 1 1.00 1.00 0.64 0.79 AA521091 0.80 1.00 0.91 1
    79132_at2, 3 U95-D 1 0.50 1.00 0.65 0.86 T66059 0.20 1.00 0.72 1

    226148_at2, 3 U133-B 1 1.00 1.00 -- -- AU144305 0.60 1.00 0.82 1

    225845_at2, 3 U133-B 1 1.00 1.00 -- -- BG253884 0.20 1.00 0.72 1

    226148_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    225845_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554469_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554470_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ZBTB44 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.719099
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZBTB44 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZBTB441   -- zinc finger and BTB domain containing 44 94.22(n)
    98.44(a)
    489277  XM_546395.2  XP_546395.1 
    chimpanzee
    (Pan troglodytes)
    ZBTB441   -- zinc finger and BTB domain containing 44 99.63(n)
    100(a)
    451668  XM_508864.2  XP_508864.2 
    cow
    (Bos taurus)
    ZBTB441   -- zinc finger and BTB domain containing 44 93.7(n)
    96.89(a)
    540532  XM_864070.2  XP_869163.2 
    rat
    (Rattus norvegicus)
    Zbtb441   -- zinc finger and BTB domain containing 44 91.39(n)
    96.69(a)
    363035  NM_001034942.1  NP_001030114.1 
    mouse
    (Mus musculus)
    Zbtb441, 5 95
    zinc finger and BTB domain containing 441, 5 91.72(n)1
    96.32(a)1
    2351321  NM_172765.21  NP_766353.21 
     AI5497955  AI8496255  (see all 16)
    About this table        Species with no ortholog for ZBTB44

    ENSEMBL Gene Tree for ZBTB44
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZBTB44 gene
    ZBTB242  ZBTB7C2  ZBTB7A2  ZBTB7B2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/361 NCBI SNPs in ZBTB44 are shown (see all 361 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 142)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs6647151,2
    A,C,F,H,O129604706(-) CAAACC/TATGAA 1 -- ut317Minor allele frequency- T:0.28NA EU EA WA 552
    rs6656541,2
    A,C,F,H,O129604495(-) TGGATC/GTTTCA 1 -- ut318Minor allele frequency- G:0.49EA NA EU WA 630
    rs6594931,2
    A,C,F,H,O129607285(+) AAAAAC/AATGAA 1 -- ut317Minor allele frequency- A:0.50NA EU EA WA 550
    rs23240551,2
    A,C,F,H129690588(+) GCGACC/ATGCGG 1 -- ng318Minor allele frequency- A:0.11EU EA WA 838
    rs4719861,2
    A,F,H129603577(+) AAAATC/TGCCTA 1 -- ut315Minor allele frequency- T:0.06MN EU EA WA 604
    --
    rs118258661,2
    C,F,H129607638(+) TCTTAA/CTAATT 1 -- ut314Minor allele frequency- C:0.01EU EA WA 410
    --
    rs22970711,2
    C,F,O129608823(-) TTCCTC/TCTTCC 1 -- ut31 trp31Minor allele frequency- T:0.35EA 1482
    rs118259721,2
    C,F,H129608151(+) TAGAGA/CATTAT 1 -- ut314Minor allele frequency- C:0.05EU EA WA 416
    rs116000981,2
    H129606075(+) TTATTC/ATGCAT 1 -- ut314Minor allele frequency- A:0.00EU EA WA 420
    rs43518241,2
    H129605556(+) AGAACA/CAAGGG 1 -- ut314Minor allele frequency- C:0.00EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for ZBTB44 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for ZBTB44 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 29068 HGNC: 25001 AceView: HSPC063 Ensembl:ENSG00000196323 euGenes: HUgn29068
    ECgene: ZBTB44 H-InvDB: ZBTB44
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB44:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB44-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ZBTB44 Antibodies for ZBTB44
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZBTB44 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (BTBD15)
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     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for ZBTB44




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ZBTB44

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