ZBTB44 Gene
protein-coding GIFtS: 44
GCID: GC11M130096
|
|
zinc finger and BTB domain containing 44(Previous name: BTB (POZ) domain containing 15 )
(Previous symbol: BTBD15)
| |
Aliases
for ZBTB44 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 441 2 | | BTB (POZ) Domain Containing 151 2 | | BTBD151 2 3 | | Zinc Finger Protein 8512 3 | | ZNF8511 2 3 | | BTB/POZ Domain-Containing Protein 152 3 | | HSPC0631 2 | | Zinc Finger And BTB Domain-Containing Protein 442 |
Export aliases for ZBTB44 gene to outside databasesPrevious GC identifers: GC11M129603 GC11M126049 |
Summaries
for ZBTB44 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT44_HUMAN, Q8NCP5Function: May be involved in transcriptional regulation (By similarity)
|
Genomic Views
for ZBTB44 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB44 gene promoter:
Spz1 LHX3b/Lhx3b FOXL1 AREB6 MEF-2A HSF2 LHX3a/Lhx3a aMEF-2 LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB44
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB44 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q24.3 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q24.3ZBTB44 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M130096: view genomic region
(about GC identifiers)
Start:
|
130,096,572 bp from pter |
End:
|
130,184,607 bp from pter |
Size:
|
88,036 bases |
Orientation:
|
minus strand |
|
Proteins
for ZBTB44 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT44_HUMAN, Q8NCP5 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 44 Size: 570 amino acids; 63848 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q6IPT8 Q86VJ7 Q86XX5Alternative splicing: 4 isoforms: Q8NCP5-1 Q8NCP5-2 Q8NCP5-3 Q8NCP5-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZBTB44: NX_Q8NCP5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCP5
ZBTB44 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054874.3
ENSEMBL proteins: ENSP00000435413 ENSP00000433457 ENSP00000350574 ENSP00000434177 ENSP00000432558 ENSP00000436187 ENSP00000380861 ENSP00000408079
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZBTB44 for ontologies About GeneDecksing
ZBTB44 Antibody Products:
Assay Products for ZBTB44: |
Protein
Domains /
Families
for ZBTB44 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB44 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8NCP5ProtoNet protein and cluster: Q8NCP5 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT44_HUMAN, Q8NCP5Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 4 C2H2-type zinc fingers |
Function
for ZBTB44 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT44_HUMAN, Q8NCP5Function: May be involved in transcriptional regulation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB44 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB44 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB44 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZBTB44 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZBTB44 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB44
3 Interacting proteins for ZBTB44 (Q8NCP53) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB44 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB44 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB44
Search CenterWatch for drugs/clinical trials and news about ZBTB44 / ZBT44
|
Transcripts
for ZBTB44 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB44 gene: NM_014155.4 Unigene Cluster for ZBTB44: Zinc finger and BTB domain containing 44 Hs.721470 [show with all ESTs]Unigene Representative Sequence: NM_01415510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528448 ENST00000525842(uc001qgb.4) ENST00000357899(uc001qfz.3 uc001qga.3)
ENST00000530205 ENST00000529982 ENST00000527478 ENST00000525623 ENST00000529348(uc001qgc.1)
ENST00000397753 ENST00000445008(uc001qfx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB44 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB44 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB44 (NM_014155) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB44 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB44 |
Additional cDNA sequence: AF161548.1 AK023933.1 AK024659.1 AK026770.1 AK096676.1 AK130071.1 AK314701.1 BC017675.2 BC040658.1 BC071729.1 13 DOTS entries: DT.453369 DT.95328396 DT.100646532 DT.100748982 DT.115092 DT.92070124 DT.40127822 DT.91699219 DT.95270526 DT.120736652 DT.120779902 DT.102844137 DT.40131694 24/270 AceView cDNA sequences (see all 270): CA391236 AA765505 AI983688 AK024659 AA700718 AA813872 AI866261 AA902114 BG565590 AK130071 AI140524 BM721219 BU629177 AW118079 BC017675 AA352857 AW470113 BU178474 AW673191 AI431859 CR615509 AA286906 BF224133 AA286951
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB44 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | - | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZBTB44
|
Expression
for ZBTB44 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB44 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGACTAAGGT
About this image
See ZBTB44 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB44
SOURCE GeneReport for Unigene cluster: Hs.721470
SABiosciences Custom PCR Arrays for ZBTB44
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB44
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB44 |
Orthologs
for ZBTB44 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB44 gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZBTB441 |
zinc finger and BTB domain containing 44 |
83.48(n)
92.22(a) |
|
419732 XM_417873.3 XP_417873.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ZBTB446 |
-- |
71(a) |
1 ↔ 1 |
GL343197.1(343956-352395) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.151522 |
Xenopus laevis transcribed sequence with weak similarity more |
77.61(n) |
|
BJ072977.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zbtb441 |
zinc finger and BTB domain containing 44 |
65.08(n)
69.91(a) |
|
569656 NM_001144798.1 NP_001138270.1 |
ENSEMBL Gene Tree for ZBTB44 (if available)
TreeFam Gene Tree for ZBTB44 (if available) |
Paralogs
for ZBTB44 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB44 gene
- ZBTB102 ZBTB32 ZBTB182 ZBTB8A2 ZBTB52 ENSG000002545532 HIC12 ZBTB492
- ZBTB242 GZF12 ZBTB422 HIC22 MYNN2 ZBTB462 ZBTB8B2 ZBTB172
18/55 SIMAP similar genes for ZBTB44 using alignment to 4 protein entries: ZBT44_HUMAN (see all proteins)
(see all similar genes):ZBTB7C KLHL28 KLHL18 BACH2 KLHL32 ZBTB20
KLHL2 ZBTB3 KBTBD3 ZBTB22 ZNF410 ZNF
HZF40 MYNN kr-znf3 BCL6 ZBTB38 DKFZp686N0199
ZBTB44 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZBTB44
PGOHUM00000257956 PGOHUM00000247561
|
Genomic Variants
for ZBTB44 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB44 (130096572 - 130184607 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ZBTB44
5 CNVs: 3869 6906 10383 9200 2962 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB44 |
|
Disorders
/ Diseases
for ZBTB44 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBTB44 for disorders About GeneDecksing
1  disease for ZBTB44: About MalaCardsretinitis
Export disorders for ZBTB44 gene to outside databases
|
Publications
for ZBTB44 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB44 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZBTB44) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (2000)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for ZBTB44 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB44 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB44 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB44 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB44 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB44 gene:
Search GeneIP for patents involving ZBTB44
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB44 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 |
 | | | ZBTB44 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB44 |
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