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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB43 Gene

protein-coding   GIFtS: 47
GCID: GC09P129567

Zinc Finger And BTB Domain Containing 43

(Previous name: zinc finger protein 297B)
(Previous symbol: ZNF297B)
  Search for ZBTB43
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 431 2     ZNF-X2
Zinc Finger Protein 297B1 2 3     Zinc Finger And BTB Domain-Containing Protein 432
ZNF297B1 2 3     KIAA04143
Zinc Finger And BTB Domain-Containing Protein 22B2 3     ZnF-x3
ZBTB22B2 3     

External Ids:    HGNC: 179081   Entrez Gene: 230992   Ensembl: ENSG000001691557   UniProtKB: O432983   

Export aliases for ZBTB43 gene to outside databases

Previous GC identifers: GC09P128607 GC09P099180


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZBTB43 Gene: 
ZBTB43 (zinc finger and BTB domain containing 43) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZBTB34.

UniProtKB/Swiss-Prot: ZBT43_HUMAN, O43298
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB43 gene promoter:
         SRF   NCX/Ncx   SRF (504 AA)   c-Ets-1   RORalpha1   CP2   FOXO4   FOXO1a   TGIF   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB43 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB43

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

ZBTB43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB43 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P129567:  view genomic region     (about GC identifiers)

Start:
129,567,285 bp from pter      End:
129,600,489 bp from pter
Size:
33,205 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZBT43_HUMAN, O43298 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 43  
Size: 467 amino acids; 52630 Da
Subunit: Interacts with BDP1
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA24844.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ZBTB43:
2CSH (3D)    
Secondary accessions: Q5JU96

Explore the universe of human proteins at neXtProt for ZBTB43: NX_O43298

Explore proteomics data for ZBTB43 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43298

  • ZBTB43 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBTB43 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129248.1  NP_054726.1  

    ENSEMBL proteins: 
     ENSP00000362563   ENSP00000412145   ENSP00000362556   ENSP00000390344  

    Human Recombinant Protein Products for ZBTB43: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZBTB43 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZBTB43 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry O43298

    ProtoNet protein and cluster: O43298

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZBT43_HUMAN, O43298
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 3 C2H2-type zinc fingers


    ZBTB43 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT43_HUMAN, O43298
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZBTB43 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB43:
     Decreased Hepatitis C virus re 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBTB43 
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    SwitchGear 3'UTR luciferase reporter plasmidZBTB43 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB43

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/21 Interacting proteins for ZBTB43 (O432983 ENSP000003625564) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    ENSG00000233911Q018603I2D: score=2 
    ENSG00000235068Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZBTB43 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB43 (ZBT43)

    Search CenterWatch for drugs/clinical trials and news about ZBTB43 / ZBT43

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZBTB43 gene (2 alternative transcripts): 
    NM_001135776.1  NM_014007.3  

    Unigene Cluster for ZBTB43:

    Zinc finger and BTB domain containing 43
    Hs.355581  [show with all ESTs]
    Unigene Representative Sequence: NM_014007
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373464(uc004bql.3) ENST00000450858 ENST00000373457(uc022bnm.1)
    ENST00000497064 ENST00000449886(uc010mxf.3)
    miRNA
    Products:
         
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    8/137 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB43 (see all 137):
    hsa-miR-124* hsa-miR-361-5p hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-3653 hsa-miR-502-3p hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidZBTB43 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AF049907.1 AK026123.1 BC008828.2 BT007194.1 

    7 DOTS entries:

    DT.100836684  DT.87000319  DT.92427677  DT.95162953  DT.121158459  DT.97861380  DT.91745601 

    24/167 AceView cDNA sequences (see all 167):

    BF223628 BU932015 CF265007 AI272842 AA630231 AL599920 AL599921 AW292236 
    BF445121 AA418119 AA405809 AI467863 BF432986 T17293 BX098962 BP353178 
    BF590733 CA429928 BX324302 Z40792 BM668233 AI680916 BE219056 BM692917 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB43    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:              -     -           -                           
    SP2:                                -                           
    SP3:                                -                           
    SP4:                                                            
    SP5:                          -     -                           


    ECgene alternative splicing isoforms for ZBTB43

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZBTB43 Expression
    About this image


    See ZBTB43 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB43

    SOURCE GeneReport for Unigene cluster: Hs.355581
        SABiosciences Custom PCR Arrays for ZBTB43
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB43 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb431 , 5 zinc finger and BTB domain containing 431, 5 88.51(n)1
    92.93(a)1
      2 (22.46 cM)5
    718341  NM_027947.21  NP_082223.21 
     334502875 
    chicken
    (Gallus gallus)
    Aves ZBTB431 zinc finger and BTB domain containing 43 79.02(n)
    87.07(a)
      417091  XM_415377.2  XP_415377.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB436
    Uncharacterized protein
    83(a)
    1 ↔ 1
    GL343502.1(313756-315132)
    zebrafish
    (Danio rerio)
    Actinopterygii zbtb431 zinc finger and BTB domain containing 43 58.67(n)
    59.09(a)
      557590  NM_001110024.1  NP_001103494.1 


    ENSEMBL Gene Tree for ZBTB43 (if available)
    TreeFam Gene Tree for ZBTB43 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB43 gene
    ZBTB342  ZBTB222  NACC12  ZBTB452  ZBTB62  ZBTB92  NACC22  ZBTB372  
    ZBTB262  ZBTB122  ZBTB202  
    7 SIMAP similar genes for ZBTB43 using alignment to 2 protein entries:     ZBT43_HUMAN (see all proteins):
    ZBTB45    ZBTB22    NACC1    KLHL32    ZBTB20    BACH2
    ZBTB37

    ZBTB43 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/819 SNPs in ZBTB43 are shown (see all 819)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727625641,2
    C,F--129565371(+) AGTGTA/CTCCAT 2 -- us2k15Minor allele frequency- C:0.08NA WA EA 362
    rs736684131,2
    C,F--129565459(+) TCCTCG/AATATT 2 -- us2k13Minor allele frequency- A:0.47WA CSA 122
    rs1125652941,2
    C,F--129565701(+) AGTATG/ACTCAA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1810660191,2
    --129565719(+) GGGTGC/TAGTTG 2 -- us2k10--------
    rs595085661,2
    C,F--129565758(+) AGGCCG/AAGGCG 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1858558841,2
    --129565762(+) CGAGGC/TGGTTG 2 -- us2k10--------
    rs1402370221,2
    --129565953(+) CCACTA/GCATTC 2 -- us2k10--------
    rs74693261,2
    C,F--129565995(+) caaaaC/Aaaaac 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1134928381,2
    C,F--129566012(+) AAACAG/AAACAA 2 -- us2k12Minor allele frequency- A:0.33CSA 3
    rs1434382681,2
    --129566057(+) TGAAGC/TAGAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZBTB43 (129567285 - 129600489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZBTB43:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270343CNV Insertion20981092
    esv1064562CNV Insertion17803354
    esv273370CNV Insertion20981092
    nsv831724CNV Gain17160897
    nsv893849CNV Gain21882294
    esv259485OTHER Complex20981092

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZBTB43 for disorders           About MalaCards

    ZBTB43 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZBTB43
    Human Genome Epidemiology (HuGE) Navigator: ZBTB43 (1 document)

    Export disorders for ZBTB43 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB43 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZBTB43)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Detecting rare variants for complex traits using fami ly and unrelated data. (PubMed id 19847924)1, 4 Zhu X....Elston R.C. (2010)
    2. The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB. (PubMed id 16542149)1, 2 Schoenen F. and Wirth B. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23099 HGNC: 17908 AceView: ZNF297B Ensembl:ENSG00000169155 euGenes: HUgn23099
    ECgene: ZBTB43 H-InvDB: ZBTB43

    (According to HUGE)
    About This Section
    HUGE: KIAA0414

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB43 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZBTB43 gene:
    Search GeneIP for patents involving ZBTB43

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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