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ZBTB43 Gene

protein-coding   GIFtS: 49

GC09P128607
zinc finger and BTB domain containing 43
(Previous name: zinc finger protein 297B )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF297B)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ22470 1
KIAA0414 1, 3
OTTHUMP00000022155 2
OTTHUMP00000022157 2
ZBTB22B 1, 2, 3
ZNF-X 1, 2
ZNF297B 2, 3
ZnF-x 3
Descriptions
Zinc finger and BTB domain-containing protein 22B 3
Zinc finger protein 297B 1, 2, 3
zinc finger and BTB domain containing 43 2
External Ids
HGNC: 179081
Entrez Gene: 230992
UniProtKB: O432983
Ensembl: ENSG000001691557
Search outside databases for aliases for ZBTB43 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ZBT43_HUMAN, O43298
Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB43 gene  

Entrez Gene cytogenetic band: 9q33-q34   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9p24.1-q22.33

ZBTB43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P128607:     (about GC identifiers)

Start:
128,607,126 bp from pter
End:
128,639,203 bp from pter
Size:
32,078 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000009.10  NT_008470.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBT43_HUMAN, O43298 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 43  
Size: 467 amino acids; 52630 Da
Subunit: Interacts with BDP1
Subcellular location: Nucleus (Probable)
PDB structures from and Proteopedia :
2CSH (3D)    

REFSEQ proteins (2 alternative transcripts): 
NP_001129248.1  NP_054726.1  


ENSEMBL proteins: 
ENSP00000362563 ENSP00000362556 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ZBTB43)
Human Recombinant Proteins from Abnova (ZNF297B)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
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Antibodies for ZBTB43: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for ZBTB43
Browse R&D Systems for Antibodies
Antibodies from Abcam (ZBTB43), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for ZBTB43

Assays for ZBTB43: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5/6 InterPro domains/families (see all 6 ):
 IPR000210 BTB/POZ-like
 IPR015880 Znf_C2H2-like
 IPR011333 BTB/POZ_fold
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR013069 BTB_POZ


   GeneDecks  ZBTB43 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry O43298

ProtoNet protein and cluster: O43298

2 Blocks protein families:
IPB000210 BTB/POZ domain
IPB007086 C2H2-type zinc finger signature


UniProtKB/Swiss-Prot: ZBT43_HUMAN, O43298
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 1 BTB (POZ) domain
Similarity: Contains 3 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBTB43)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZNF297B)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001135776

              Applied Biosystems Silencer® siRNAs for ZBTB43

              Sigma-Aldrich siRNA and siRNA Panels for ZBTB43  
                     Sigma-Aldrich shRNA for ZBTB43  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for ZBTB43
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001135776
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001135776
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001135776 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_014007

UniProtKB/Swiss-Prot: ZBT43_HUMAN, O43298
Function: May be involved in transcriptional regulation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
GO:0005515 protein binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for ZBTB43 (ENSP000003625563) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
BDP1ENSP000003515753STRING (score=.724)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB43

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBTB43)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZNF297B)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001135776

              Sigma-Aldrich siRNA and siRNA Panels for ZBTB43  
                     Sigma-Aldrich shRNA for ZBTB43  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001135776  NM_014007  

REFSEQ mRNAs for ZBTB43 gene (2 alternative transcripts): 

NM_001135776.1   NM_014007.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001135776  NM_014007  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001135776
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001135776
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001135776 

Additional cDNA sequence: BT007194.1 

8 DOTS entries:

DT.100836684  DT.87000319  DT.92427677  DT.95162953  DT.121158459  DT.97861380  DT.100774842  DT.91745601 

24/167 AceView cDNA sequences (see all 167 ):

T92685 BM838233 BP335448 BQ773935 BF432986 BF433622 AI684662 CF265007 
AI263405 AA630231 BP353178 BX324302 BE503618 AA405809 AI129167 BF590733 
AI467863 AI680916 BE219056 BQ016945 BM724980 AL599920 BF446503 BE503194 

highest scoring ESTs for ZBTB43:

AA362694 AA465708 AA557630 AA602493 AA702698 AA749109 AA782743 AA813602 AA814473 AA829825 

Unigene Clusters for ZBTB43:

Zinc finger and BTB domain containing 43
Hs.355581  [show with all ESTs], Hs.718657  [show with all ESTs]
Unigene Representative Sequences: NM_014007, BT007194


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB43

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1:              -     -           -                           
SP2:                                -                           
SP3:                                -                           
SP4:                                                            
SP5:                          -     -                           

About this scheme

ECgene alternative splicing isoforms for ZBTB43

2 Ensembl transcripts including schematic representations:
ENST00000373464  ENST00000373457  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB43 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB43

1 / 2 / 3

10 probe-sets matching ZBTB43 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

41695_at2, 3 U95-A 1 1.00 1.00 0.91 0.70 AB007874 0.60 1.00 0.82 1
47165_at2, 3 U95-B 3 1.00 0.77 0.86 1.31 AI582592 0.60 1.00 0.82 1

204180_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI745225 0.80 1.00 0.91 1

204182_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014007 0.40 1.00 0.76 1

204181_s_at2, 3 U133-A 1 1.00 1.00 -- -- T90308 0.60 1.00 0.82 1

227991_x_at2, 3 U133-B 2 1.00 0.95 -- -- BF516567 0.40 1.00 0.76 1

204180_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

204182_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

204181_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

227991_x_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
GeneDecks  ZBTB43 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TGACTTCTTG

SOURCE GeneReport for Unigene clusters: Hs.355581 Hs.718657
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ZBTB43 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ZBTB431   -- zinc finger and BTB domain containing 43 94(n)
98.72(a)
612870  XM_846547.1  XP_851640.1 
chimpanzee
(Pan troglodytes)
ZBTB431   -- zinc finger and BTB domain containing 43 99.86(n)
100(a)
473063  XM_528433.2  XP_528433.2 
cow
(Bos taurus)
ZBTB431   -- zinc finger and BTB domain containing 43 92.63(n)
98.07(a)
509462  NM_001024503.1  NP_001019674.1 
rat
(Rattus norvegicus)
Zbtb431   -- zinc finger and BTB domain containing 43 89.08(n)
91.65(a)
311872  NM_001012094.1  NP_001012094.1 
mouse
(Mus musculus)
Zbtb431, 5 25
zinc finger and BTB domain containing 431, 5 88.58(n)1
92.93(a)1
718341  NM_027947.21  NP_082223.21 
 AI8527095  AK0058185  (see all 14)
About this table        Species with no ortholog for ZBTB43

ENSEMBL Gene Tree for ZBTB43
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ZBTB43 gene
ZBTB342  ZBTB222  ZBTB92  ZBTB372  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/171 NCBI SNPs in ZBTB43 are shown (see all 171 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 61)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs13601381,2
A,C,F,H128607165(-) CTGTTG/CTAGCC 2 -- ut51 ese38Minor allele frequency- C:0.13MN EU EA WA NA 708
rs64787581,2
A,C,F,H128638362(+) GGTAGT/ATTTGG 2 -- ut318Minor allele frequency- A:0.04EU EA WA 836
rs13601391,2
A,C,F,H128606916(-) GATACT/CGAGTT 1 -- ng5113Minor allele frequency- C:0.11EU EA WA NA 1152
rs11226111,2
C,F,H128639527(+) CCTCCA/GGGGCT 2 -- ut31 ese35Minor allele frequency- G:0.13EU EA WA MN 602
rs126838871,2
C,F,H128636886(+) GACCAC/TGGTAC 2 -- ut31 ese36Minor allele frequency- T:0.20EU EA WA 596
rs78623671,2
H128638008(+) GTAGAG/AGCCAG 2 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 420
--
rs126861741,2
C128607164(+) AGGCTA/GCAACA 2 -- ut51 ese30--------
--
rs78666281,2
A128639136(+) gaggcA/Ggaggt 2 -- ut31 ese30--------
rs31189941,2
A,C,F,H128635716(+) GCCACC/TGACAA 2 T/T syn15Minor allele frequency- T:0.12EU EA WA NA 496
rs357963921,2
F128635404(+) TACGAC/TGAGCA 2 D/D syn11Minor allele frequency- T:0.06NA 78
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HapMap Linkage Disequilibrium images for ZBTB43 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

6 PubMed articles for ZBTB43 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23099 HGNC: 17908 AceView: ZNF297B Ensembl:ENSG00000169155 euGenes: HUgn23099
ECgene: ZBTB43 H-InvDB: ZBTB43
(According to HUGE)
About This Section

HUGE: KIAA0414
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ZBTB43:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB43-related products

 Millipore Custom Antibody & Bulk Services
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 Millipore Immunoassay Services
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 Predesigned and custom siRNAs for ZBTB43 Antibodies for ZBTB43
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for ZBTB43 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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