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Aliases for ZBTB43 Gene

Aliases for ZBTB43 Gene

  • Zinc Finger And BTB Domain Containing 43 2 3 5
  • Zinc Finger Protein 297B 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 22B 3 4
  • ZNF297B 3 4
  • ZBTB22B 3 4
  • ZNF-X 3 4
  • Zinc Finger And BTB Domain-Containing Protein 43 3
  • KIAA0414 4

External Ids for ZBTB43 Gene

Previous HGNC Symbols for ZBTB43 Gene

  • ZNF297B

Previous GeneCards Identifiers for ZBTB43 Gene

  • GC09P128607
  • GC09P129567
  • GC09P099180

Summaries for ZBTB43 Gene

GeneCards Summary for ZBTB43 Gene

ZBTB43 (Zinc Finger And BTB Domain Containing 43) is a Protein Coding gene. An important paralog of this gene is ZBTB22.

UniProtKB/Swiss-Prot for ZBTB43 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB43 Gene

Genomics for ZBTB43 Gene

Regulatory Elements for ZBTB43 Gene

Enhancers for ZBTB43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F126763 0.3 FANTOM5 17.4 -40.5 -40485 0.2 TBP PKNOX1 KLF1 NFYB PRDM10 FOS SP3 ZNF362 BHLHE40 USF2 ZBTB43 LMX1B LOC105376277 ENSG00000226078 MVB12B PIR57638
GH09F126841 0.8 Ensembl ENCODE 16.1 +39.2 39225 3.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF121 ZNF143 ZBTB43 ZBTB34
GH09F126838 0.5 ENCODE 11.9 +34.5 34451 0.6 KLF17 KLF7 SMARCA5 JUNB ZEB2 TBX21 ZNF623 ZNF217 ZFP69B RAD51 ZBTB34 ZBTB43 RALGPS1
GH09F126754 0.2 ENCODE 11.6 -49.1 -49136 0.2 PKNOX1 FEZF1 ZNF843 GLIS1 ZNF512 ZNF341 ZNF580 PRDM10 ZNF423 ZBTB43 PIR57638
GH09F126752 0.5 ENCODE 11.5 -51.5 -51476 0.2 ZNF680 PKNOX1 NR2F1 MNT CBX5 SCRT2 NR2F6 TRIM28 ZBTB43 PIR57638
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZBTB43 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001475156 1628 2601 HDGF PKNOX1 MLX ARID4B SIN3A YBX1 DMAP1 YY1 SLC30A9 FOS

Genomic Location for ZBTB43 Gene

Chromosome:
9
Start:
126,804,072 bp from pter
End:
126,838,210 bp from pter
Size:
34,139 bases
Orientation:
Plus strand

Genomic View for ZBTB43 Gene

Genes around ZBTB43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB43 Gene

Proteins for ZBTB43 Gene

  • Protein details for ZBTB43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43298-ZBT43_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 43
    Protein Accession:
    O43298
    Secondary Accessions:
    • Q5JU96

    Protein attributes for ZBTB43 Gene

    Size:
    467 amino acids
    Molecular mass:
    52630 Da
    Quaternary structure:
    • Interacts with BDP1.
    SequenceCaution:
    • Sequence=BAA24844.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB43 Gene

neXtProt entry for ZBTB43 Gene

Post-translational modifications for ZBTB43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB43 Gene

No data available for DME Specific Peptides for ZBTB43 Gene

Domains & Families for ZBTB43 Gene

Gene Families for ZBTB43 Gene

Suggested Antigen Peptide Sequences for ZBTB43 Gene

Graphical View of Domain Structure for InterPro Entry

O43298

UniProtKB/Swiss-Prot:

ZBT43_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB43: view

Function for ZBTB43 Gene

Molecular function for ZBTB43 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB43: view
genes like me logo Genes that share phenotypes with ZBTB43: view

Animal Model Products

miRNA for ZBTB43 Gene

miRTarBase miRNAs that target ZBTB43

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB43 Gene

Localization for ZBTB43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB43 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB43 Gene COMPARTMENTS Subcellular localization image for ZBTB43 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ZBTB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB43: view

Pathways & Interactions for ZBTB43 Gene

SuperPathways for ZBTB43 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB43: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB43 Gene

Transcripts for ZBTB43 Gene

Unigene Clusters for ZBTB43 Gene

Zinc finger and BTB domain containing 43:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB43 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: - -

Relevant External Links for ZBTB43 Gene

GeneLoc Exon Structure for
ZBTB43
ECgene alternative splicing isoforms for
ZBTB43

Expression for ZBTB43 Gene

mRNA expression in normal human tissues for ZBTB43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB43 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for ZBTB43 Gene

This gene is overexpressed in Testis (51.6) and Pancreas (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB43 Gene



Protein tissue co-expression partners for ZBTB43 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB43 Gene:

ZBTB43

SOURCE GeneReport for Unigene cluster for ZBTB43 Gene:

Hs.355581
genes like me logo Genes that share expression patterns with ZBTB43: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZBTB43 Gene

Orthologs for ZBTB43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB43 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia ZBTB43 34 35
  • 93.93 (n)
cow
(Bos Taurus)
Mammalia ZBTB43 34
  • 92.7 (n)
ZNF297B 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB43 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb43 34
  • 89.01 (n)
mouse
(Mus musculus)
Mammalia Zbtb43 34 16 35
  • 88.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB43 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB43 34 35
  • 79.02 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB43 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb43 34
  • 71.05 (n)
zebrafish
(Danio rerio)
Actinopterygii zbtb43 34 35
  • 59.34 (n)
Species where no ortholog for ZBTB43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB43 Gene

ENSEMBL:
Gene Tree for ZBTB43 (if available)
TreeFam:
Gene Tree for ZBTB43 (if available)

Paralogs for ZBTB43 Gene

(7) SIMAP similar genes for ZBTB43 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZBTB43: view

Variants for ZBTB43 Gene

Sequence variations from dbSNP and Humsavar for ZBTB43 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10124860 -- 126,811,064(+) taaaa(A/G)cacaa intron-variant
rs10435899 -- 126,802,082(+) cgctg(C/T)agcct upstream-variant-2KB
rs10435900 -- 126,830,365(+) TTGGG(A/G)CTGGG intron-variant
rs10819235 -- 126,807,879(+) GATCC(A/T)CCTGC intron-variant
rs10819236 -- 126,814,100(+) CCTAC(A/T)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB43 Gene

Variant ID Type Subtype PubMed ID
dgv4140n106 CNV tandem duplication 24896259
esv1064562 CNV insertion 17803354
esv3302511 CNV tandem duplication 20981092
esv3306066 CNV mobile element insertion 20981092
esv3323931 CNV duplication 20981092
esv3335630 CNV insertion 20981092
esv3355530 CNV insertion 20981092
esv3576707 CNV gain 25503493
esv3621766 CNV gain 21293372
nsv831724 CNV gain 17160897

Variation tolerance for ZBTB43 Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB43 Gene

Disorders for ZBTB43 Gene

Relevant External Links for ZBTB43

Genetic Association Database (GAD)
ZBTB43
Human Genome Epidemiology (HuGE) Navigator
ZBTB43
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB43

No disorders were found for ZBTB43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB43 Gene

Publications for ZBTB43 Gene

  1. Detecting rare variants for complex traits using family and unrelated data. (PMID: 19847924) Zhu X. … Elston R.C. (Genet. Epidemiol. 2010) 3 46 64
  2. The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB. (PMID: 16542149) Schoenen F. … Wirth B. (Biol. Chem. 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ZBTB43 Gene

Sources for ZBTB43 Gene

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