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Aliases for ZBTB43 Gene

Aliases for ZBTB43 Gene

  • Zinc Finger And BTB Domain Containing 43 2 3 5
  • Zinc Finger Protein 297B 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 22B 3 4
  • ZNF297B 3 4
  • ZBTB22B 3 4
  • ZNF-X 3 4
  • KIAA0414 4

External Ids for ZBTB43 Gene

Previous HGNC Symbols for ZBTB43 Gene

  • ZNF297B

Previous GeneCards Identifiers for ZBTB43 Gene

  • GC09P128607
  • GC09P129567
  • GC09P099180

Summaries for ZBTB43 Gene

GeneCards Summary for ZBTB43 Gene

ZBTB43 (Zinc Finger And BTB Domain Containing 43) is a Protein Coding gene. An important paralog of this gene is ZBTB22.

UniProtKB/Swiss-Prot for ZBTB43 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB43 Gene

Genomics for ZBTB43 Gene

Regulatory Elements for ZBTB43 Gene

Enhancers for ZBTB43 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZBTB43 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB43 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB43 Gene

126,804,072 bp from pter
126,838,210 bp from pter
34,139 bases
Plus strand

Genomic View for ZBTB43 Gene

Genes around ZBTB43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB43 Gene

Proteins for ZBTB43 Gene

  • Protein details for ZBTB43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 43
    Protein Accession:
    Secondary Accessions:
    • Q5JU96

    Protein attributes for ZBTB43 Gene

    467 amino acids
    Molecular mass:
    52630 Da
    Quaternary structure:
    • Interacts with BDP1.
    • Sequence=BAA24844.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB43 Gene

neXtProt entry for ZBTB43 Gene

Proteomics data for ZBTB43 Gene at MOPED

Post-translational modifications for ZBTB43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB43 Gene

No data available for DME Specific Peptides for ZBTB43 Gene

Domains & Families for ZBTB43 Gene

Gene Families for ZBTB43 Gene

Suggested Antigen Peptide Sequences for ZBTB43 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB43: view

Function for ZBTB43 Gene

Molecular function for ZBTB43 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZBTB43: view

Animal Model Products

miRNA for ZBTB43 Gene

miRTarBase miRNAs that target ZBTB43

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB43 Gene

Localization for ZBTB43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB43 Gene

Subcellular locations from

Jensen Localization Image for ZBTB43 Gene COMPARTMENTS Subcellular localization image for ZBTB43 gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for ZBTB43 Gene

Pathways & Interactions for ZBTB43 Gene

SuperPathways for ZBTB43 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB43 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZBTB43 Gene

Drugs & Compounds for ZBTB43 Gene

No Compound Related Data Available

Transcripts for ZBTB43 Gene

Unigene Clusters for ZBTB43 Gene

Zinc finger and BTB domain containing 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB43 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: -
SP3: -
SP5: - -

Relevant External Links for ZBTB43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB43 Gene

mRNA expression in normal human tissues for ZBTB43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB43 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for ZBTB43 Gene

This gene is overexpressed in Testis (51.6) and Pancreas (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB43 Gene

SOURCE GeneReport for Unigene cluster for ZBTB43 Gene Hs.355581

genes like me logo Genes that share expression patterns with ZBTB43: view

Protein tissue co-expression partners for ZBTB43 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZBTB43 Gene

Orthologs for ZBTB43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB43 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZBTB43 35
  • 92.7 (n)
  • 98.07 (a)
ZNF297B 36
  • 92 (a)
(Canis familiaris)
Mammalia ZBTB43 35
  • 93.93 (n)
  • 98.72 (a)
ZBTB43 36
  • 88 (a)
(Mus musculus)
Mammalia Zbtb43 35
  • 88.51 (n)
  • 92.93 (a)
Zbtb43 16
Zbtb43 36
  • 86 (a)
(Pan troglodytes)
Mammalia ZBTB43 35
  • 99.79 (n)
  • 100 (a)
ZBTB43 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zbtb43 35
  • 89.01 (n)
  • 91.65 (a)
(Monodelphis domestica)
Mammalia ZBTB43 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB43 36
  • 86 (a)
(Gallus gallus)
Aves ZBTB43 35
  • 79.02 (n)
  • 87.07 (a)
ZBTB43 36
  • 87 (a)
(Anolis carolinensis)
Reptilia ZBTB43 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb43 35
  • 71.05 (n)
  • 76.32 (a)
(Danio rerio)
Actinopterygii zbtb43 35
  • 59.34 (n)
  • 59.85 (a)
zbtb43 36
  • 53 (a)
Species with no ortholog for ZBTB43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB43 Gene

Gene Tree for ZBTB43 (if available)
Gene Tree for ZBTB43 (if available)

Paralogs for ZBTB43 Gene

(7) SIMAP similar genes for ZBTB43 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZBTB43: view

Variants for ZBTB43 Gene

Sequence variations from dbSNP and Humsavar for ZBTB43 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs873836 -- 126,805,336(+) CGGCG(C/T)GCAGA intron-variant, upstream-variant-2KB
rs873837 -- 126,805,553(+) GACTT(A/C)GCTGA intron-variant, utr-variant-5-prime
rs937427 -- 126,838,431(+) CCCTG(C/G)GCCCC downstream-variant-500B
rs999563 -- 126,838,433(-) AGGGG(A/G)CCCAG downstream-variant-500B
rs999564 -- 126,838,292(-) AAAAC(A/G)CCACC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZBTB43 Gene

Variant ID Type Subtype PubMed ID
nsv893849 CNV Gain 21882294
nsv831724 CNV Gain 17160897
esv270343 CNV Insertion 20981092
esv259485 OTHER Complex 20981092
esv1064562 CNV Insertion 17803354
esv273370 CNV Insertion 20981092

Variation tolerance for ZBTB43 Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZBTB43 Gene

Disorders for ZBTB43 Gene

Relevant External Links for ZBTB43

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZBTB43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB43 Gene

Publications for ZBTB43 Gene

  1. Detecting rare variants for complex traits using family and unrelated data. (PMID: 19847924) Zhu X. … Elston R.C. (Genet. Epidemiol. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZBTB43 Gene

Sources for ZBTB43 Gene