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Aliases for ZBTB43 Gene

Aliases for ZBTB43 Gene

  • Zinc Finger And BTB Domain Containing 43 2 3
  • Zinc Finger Protein 297B 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 22B 3 4
  • ZNF297B 3 4
  • ZBTB22B 3 4
  • ZNF-X 3 4
  • Zinc Finger And BTB Domain-Containing Protein 43 3
  • KIAA0414 4

External Ids for ZBTB43 Gene

Previous Symbols for ZBTB43 Gene

  • ZNF297B

Summaries for ZBTB43 Gene

GeneCards Summary for ZBTB43 Gene

ZBTB43 (Zinc Finger And BTB Domain Containing 43) is a Protein Coding gene. An important paralog of this gene is NACC2.

UniProtKB/Swiss-Prot for ZBTB43 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB43 Gene

Genomics for ZBTB43 Gene

Genomic Location for ZBTB43 Gene

Start:
126,805,006 bp from pter
End:
126,838,210 bp from pter
Size:
33,205 bases
Orientation:
Plus strand

Genomic View for ZBTB43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB43 Gene

Regulatory Elements for ZBTB43 Gene

Proteins for ZBTB43 Gene

  • Protein details for ZBTB43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43298-ZBT43_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 43
    Protein Accession:
    O43298
    Secondary Accessions:
    • Q5JU96

    Protein attributes for ZBTB43 Gene

    Size:
    467 amino acids
    Molecular mass:
    52630 Da
    Quaternary structure:
    • Interacts with BDP1.
    SequenceCaution:
    • Sequence=BAA24844.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB43 Gene

neXtProt entry for ZBTB43 Gene

Proteomics data for ZBTB43 Gene at MOPED

Post-translational modifications for ZBTB43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB43 Gene

No data available for DME Specific Peptides for ZBTB43 Gene

Domains for ZBTB43 Gene

Gene Families for ZBTB43 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

UniProtKB/Swiss-Prot:

ZBT43_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • O43298
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • O43298
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • O43298
genes like me logo Genes that share domains with ZBTB43: view

Function for ZBTB43 Gene

Molecular function for ZBTB43 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZBTB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB43: view

Phenotypes for ZBTB43 Gene

GenomeRNAi human phenotypes for ZBTB43:
genes like me logo Genes that share phenotypes with ZBTB43: view

miRNA for ZBTB43 Gene

miRTarBase miRNAs that target ZBTB43

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB43 Gene

Localization for ZBTB43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB43 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB43 Gene COMPARTMENTS Subcellular localization image for ZBTB43 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ZBTB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB43: view

Pathways for ZBTB43 Gene

SuperPathways for ZBTB43 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB43: view

No data available for Pathways by source for ZBTB43 Gene

Transcripts for ZBTB43 Gene

Unigene Clusters for ZBTB43 Gene

Zinc finger and BTB domain containing 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB43 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: - -

Relevant External Links for ZBTB43 Gene

GeneLoc Exon Structure for
ZBTB43
ECgene alternative splicing isoforms for
ZBTB43

Expression for ZBTB43 Gene

mRNA expression in normal human tissues for ZBTB43 Gene

mRNA differential expression in normal tissues according to GTEx for ZBTB43 Gene

This gene is overexpressed in Muscle - Skeletal (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB43 Gene

SOURCE GeneReport for Unigene cluster for ZBTB43 Gene Hs.355581

genes like me logo Genes that share expressions with ZBTB43: view

Orthologs for ZBTB43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB43 36
  • 99.79 (n)
  • 100 (a)
ZBTB43 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB43 36
  • 92.7 (n)
  • 98.07 (a)
ZNF297B 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB43 36
  • 93.93 (n)
  • 98.72 (a)
ZBTB43 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb43 36
  • 88.51 (n)
  • 92.93 (a)
Zbtb43 16
Zbtb43 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB43 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB43 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb43 36
  • 89.01 (n)
  • 91.65 (a)
chicken
(Gallus gallus)
Aves ZBTB43 36
  • 79.02 (n)
  • 87.07 (a)
ZBTB43 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB43 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb43 36
  • 71.05 (n)
  • 76.32 (a)
zebrafish
(Danio rerio)
Actinopterygii zbtb43 36
  • 59.34 (n)
  • 59.85 (a)
zbtb43 37
  • 53 (a)
OneToOne
Species with no ortholog for ZBTB43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB43 Gene

ENSEMBL:
Gene Tree for ZBTB43 (if available)
TreeFam:
Gene Tree for ZBTB43 (if available)

Paralogs for ZBTB43 Gene

Selected SIMAP similar genes for ZBTB43 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZBTB43: view

Variants for ZBTB43 Gene

Sequence variations from dbSNP and Humsavar for ZBTB43 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs503520 -- 126,825,104(-) agcca(C/G)gcatg intron-variant
rs516104 -- 126,817,908(+) TTAGC(A/G)TGTTG intron-variant
rs526641 -- 126,827,703(-) AATGA(C/T)GAGAA intron-variant
rs873836 -- 126,805,336(+) CGGCG(C/T)GCAGA intron-variant, upstream-variant-2KB
rs873837 -- 126,805,553(+) GACTT(A/C)GCTGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZBTB43 Gene

Variant ID Type Subtype PubMed ID
nsv893849 CNV Gain 21882294
nsv831724 CNV Gain 17160897
esv270343 CNV Insertion 20981092
esv259485 OTHER Complex 20981092
esv1064562 CNV Insertion 17803354
esv273370 CNV Insertion 20981092

Relevant External Links for ZBTB43 Gene

HapMap Linkage Disequilibrium report
ZBTB43

Disorders for ZBTB43 Gene

Relevant External Links for ZBTB43

Genetic Association Database (GAD)
ZBTB43
Human Genome Epidemiology (HuGE) Navigator
ZBTB43
genes like me logo Genes that share disorders with ZBTB43: view

No data available for UniProtKB/Swiss-Prot for ZBTB43 Gene

Publications for ZBTB43 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Detecting rare variants for complex traits using family and unrelated data. (PMID: 19847924) Zhu X. … Elston R.C. (Genet. Epidemiol. 2010) 3 49
  4. The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB. (PMID: 16542149) Schoenen F. … Wirth B. (Biol. Chem. 2006) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ZBTB43 Gene

Sources for ZBTB43 Gene

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