ZBTB42 Gene
protein-coding GIFtS: 38
GCID: GC14P105266
|
|
zinc finger and BTB domain containing 42
| |
Aliases
for ZBTB42 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 421 2 | | ZNF9251 2 | | Zinc Finger And BTB Domain-Containing Protein 422 |
Export aliases for ZBTB42 gene to outside databasesPrevious GC identifers: GC00U921814 GC14U900765 GC14P104339 GC14P085448 |
Summaries
for ZBTB42 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT42_HUMAN, B2RXF5Function: Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodelingmultiprotein complexes (By similarity)
|
Genomic Views
for ZBTB42 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB42 gene promoter:
CREB ATF-2 deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB42
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB42 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33ZBTB42 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P105266: view genomic region
(about GC identifiers)
Start:
|
105,266,933 bp from pter |
End:
|
105,271,049 bp from pter |
Size:
|
4,117 bases |
Orientation:
|
plus strand |
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Proteins
for ZBTB42 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT42_HUMAN, B2RXF5 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 42 Size: 422 amino acids; 46491 Da
Subcellular location: Cytoplasm (By similarity). Nucleus. Nucleus, nucleoplasm (By similarity). Note=In skeletalmyofibers, highly enriched in subsynaptic nuclei at the neuromuscular junctions (By similarity)
Secondary accessions: B7ZW21Explore the universe of human proteins at neXtProt for ZBTB42: NX_B2RXF5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_B2RXF5
ZBTB42 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001131073.1
ENSEMBL proteins: ENSP00000450673 ENSP00000409107
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZBTB42 for ontologies About GeneDecksing
ZBTB42 Antibody Products:
Assay Products for ZBTB42: |
Protein
Domains /
Families
for ZBTB42 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB42 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry B2RXF5ProtoNet protein and cluster: B2RXF5 UniProtKB/Swiss-Prot: ZBT42_HUMAN, B2RXF5Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. ZNF238 subfamilySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 4 C2H2-type zinc fingers |
Function
for ZBTB42 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT42_HUMAN, B2RXF5Function: Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodelingmultiprotein complexes (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB42
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB42 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZBTB42 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZBTB42 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB42
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- |
ZBTB42 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB42 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB42
Search CenterWatch for drugs/clinical trials and news about ZBTB42 / ZBT42
|
Transcripts
for ZBTB42 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB42 gene: NM_001137601.1 Unigene Cluster for ZBTB42: Zinc finger and BTB domain containing 42 Hs.170853 [show with all ESTs]Unigene Representative Sequence: NM_0011376012 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000555360(uc001ypp.3) ENST00000342537(uc021sem.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB42 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB42
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB42 (NM_001137601) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB42 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB42 |
Additional cDNA sequence: AK125003.1 BC157833.1 BC171822.1 1 DOTS entry: DT.305758
GeneLoc Exon Structure
|
Expression
for ZBTB42 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB42 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGACAGTAA
About this image
See ZBTB42 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB42
SOURCE GeneReport for Unigene cluster: Hs.170853
UniProtKB/Swiss-Prot: ZBT42_HUMAN, B2RXF5Tissue specificity: Expressed in skeletal muscle
SABiosciences Custom PCR Arrays for ZBTB42
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB42
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB42 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB42 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB42 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB42 |
Orthologs
for ZBTB42 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB42 gene from 3/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZBTB421 |
zinc finger and BTB domain containing 42 |
67.15(n)
62.8(a) |
|
428913 XM_426468.2 XP_426468.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ZBTB426 |
-- |
47(a) |
1 ↔ 1 |
1(3890559-3892007) |
zebrafish
(Danio rerio) |
Actinopterygii |
CR855301.16 |
-- |
39(a) |
1 ↔ 1 |
17(1019695-1034160) |
ENSEMBL Gene Tree for ZBTB42 (if available)
TreeFam Gene Tree for ZBTB42 (if available) |
Paralogs
for ZBTB42 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB42 gene
- ZBTB102 ZBTB32 ZBTB182 ZBTB8A2 ZBTB442 ZBTB52 ENSG000002545532 HIC12
- ZBTB492 ZBTB242 GZF12 HIC22 MYNN2 ZBTB462 ZBTB8B2 ZBTB172
18/23 SIMAP similar genes for ZBTB42 using alignment to 1 protein entry: ZBT42_HUMAN(see all similar genes):BACH2 ZNF72 ZFS-4 ZNF78L1 ZNF55 ZNF
KLHL32 ZFS-6 ZNF702P kr-znf3 DKFZp686O1631 HZF16
ZFS-5 ZNF468 A-328A3.4 DKFZp434J0650 PLAGL1 ZNF238
ZBTB42 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZBTB42
PGOHUM00000257834
|
Genomic Variants
for ZBTB42 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB42 (105266933 - 105271049 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZBTB42
4 CNVs: 29963 49291 29962 49292 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB42 |
|
Disorders
/ Diseases
for ZBTB42 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZBTB42 for disorders About MalaCards
ZBTB42 for disorders About GeneDecksing
OMIM gene information: 613915
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: ZBTB42 (3 documents)
Export disorders for ZBTB42 gene to outside databases
|
Publications
for ZBTB42 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB42 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZBTB42) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the ZBTB42 gene in humans and mice. (PubMed id 21193930)1, 2 Devaney S.A.... Hoffman E.P. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZBTB42 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB42 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB42 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB42 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB42 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB42 gene:
Search GeneIP for patents involving ZBTB42
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB42 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
 |
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 | | | ZBTB42 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB42 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB42 |
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