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Aliases for ZBTB41 Gene

Aliases for ZBTB41 Gene

  • Zinc Finger And BTB Domain Containing 41 2 3 5
  • FRBZ1 3 4
  • FRBZ1 Protein (FRBZ1) 3
  • ZNF924 3

External Ids for ZBTB41 Gene

Previous GeneCards Identifiers for ZBTB41 Gene

  • GC01M193860
  • GC01M195389
  • GC01M197122
  • GC01M168280

Summaries for ZBTB41 Gene

GeneCards Summary for ZBTB41 Gene

ZBTB41 (Zinc Finger And BTB Domain Containing 41) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZBTB41 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB41 Gene

Genomics for ZBTB41 Gene

Regulatory Elements for ZBTB41 Gene

Enhancers for ZBTB41 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZBTB41 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB41 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB41 Gene

Chromosome:
1
Start:
197,153,680 bp from pter
End:
197,200,542 bp from pter
Size:
46,863 bases
Orientation:
Minus strand

Genomic View for ZBTB41 Gene

Genes around ZBTB41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB41 Gene

Proteins for ZBTB41 Gene

  • Protein details for ZBTB41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SVQ8-ZBT41_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 41
    Protein Accession:
    Q5SVQ8
    Secondary Accessions:
    • A2RUA8
    • Q6MZT8
    • Q6ZR25
    • Q7Z4T1
    • Q8IZ99

    Protein attributes for ZBTB41 Gene

    Size:
    909 amino acids
    Molecular mass:
    105192 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB41 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB41 Gene

Proteomics data for ZBTB41 Gene at MOPED

Post-translational modifications for ZBTB41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB41 Gene

Domains & Families for ZBTB41 Gene

Gene Families for ZBTB41 Gene

Protein Domains for ZBTB41 Gene

Graphical View of Domain Structure for InterPro Entry

Q5SVQ8

UniProtKB/Swiss-Prot:

ZBT41_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 14 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB41: view

Function for ZBTB41 Gene

Molecular function for ZBTB41 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZBTB41: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB41 Gene

Localization for ZBTB41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB41 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB41 Gene COMPARTMENTS Subcellular localization image for ZBTB41 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZBTB41 Gene

Pathways & Interactions for ZBTB41 Gene

SuperPathways for ZBTB41 Gene

No Data Available

Interacting Proteins for ZBTB41 Gene

Gene Ontology (GO) - Biological Process for ZBTB41 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZBTB41 Gene

Drugs & Compounds for ZBTB41 Gene

No Compound Related Data Available

Transcripts for ZBTB41 Gene

mRNA/cDNA for ZBTB41 Gene

Unigene Clusters for ZBTB41 Gene

Zinc finger and BTB domain containing 41:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB41 Gene

No ASD Table

Relevant External Links for ZBTB41 Gene

GeneLoc Exon Structure for
ZBTB41
ECgene alternative splicing isoforms for
ZBTB41

Expression for ZBTB41 Gene

mRNA expression in normal human tissues for ZBTB41 Gene

Protein differential expression in normal tissues from HIPED for ZBTB41 Gene

This gene is overexpressed in Testis (35.3) and Spleen (33.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB41 Gene



SOURCE GeneReport for Unigene cluster for ZBTB41 Gene Hs.529439

genes like me logo Genes that share expression patterns with ZBTB41: view

Protein tissue co-expression partners for ZBTB41 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB41 Gene

Orthologs for ZBTB41 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB41 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBTB41 35
  • 91.72 (n)
  • 96.64 (a)
ZBTB41 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB41 35
  • 93.58 (n)
  • 96.81 (a)
ZBTB41 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb41 35
  • 88.68 (n)
  • 93.94 (a)
Zbtb41 16
Zbtb41 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBTB41 35
  • 99.74 (n)
  • 99.78 (a)
ZBTB41 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb41 35
  • 88.9 (n)
  • 94.49 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBTB41 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB41 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB41 35
  • 78.75 (n)
  • 83.31 (a)
ZBTB41 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB41 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb41 35
  • 67.7 (n)
  • 69.48 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC573743 35
  • 63.92 (n)
  • 64.12 (a)
ZBTB41 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12942 36
  • 10 (a)
OneToMany
CG30020 36
  • 8 (a)
OneToMany
CG7101 36
  • 28 (a)
OneToMany
Species with no ortholog for ZBTB41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB41 Gene

ENSEMBL:
Gene Tree for ZBTB41 (if available)
TreeFam:
Gene Tree for ZBTB41 (if available)

Paralogs for ZBTB41 Gene

(387) SIMAP similar genes for ZBTB41 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZBTB41: view

No data available for Paralogs for ZBTB41 Gene

Variants for ZBTB41 Gene

Sequence variations from dbSNP and Humsavar for ZBTB41 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_030601 -
rs1127661 -- 197,153,913(-) AGGAT(A/G)CTTTA utr-variant-3-prime
rs1415212 -- 197,188,764(+) AGGAA(A/T)AAAAG intron-variant
rs1415213 -- 197,188,864(+) GTCTA(A/T)AAATT intron-variant
rs1415217 -- 197,182,116(+) CAGTA(C/T)TTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB41 Gene

Variant ID Type Subtype PubMed ID
nsv528460 CNV Gain 19592680
esv743 CNV CNV 17122850
essv19099 CNV CNV 17122850
nsv873070 CNV Gain+Loss 21882294
dgv515n71 CNV Loss 21882294
esv2445525 CNV Deletion 19546169

Variation tolerance for ZBTB41 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB41 Gene

Human Gene Mutation Database (HGMD)
ZBTB41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB41 Gene

Disorders for ZBTB41 Gene

Relevant External Links for ZBTB41

Genetic Association Database (GAD)
ZBTB41
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB41

No disorders were found for ZBTB41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB41 Gene

Publications for ZBTB41 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung S.A. … Langefeld C.D. (J. Am. Soc. Nephrol. 2014) 3
  4. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. (PMID: 23381943) Williams F.M. … . (Ann. Neurol. 2013) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZBTB41 Gene

Sources for ZBTB41 Gene

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