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Aliases for ZBTB41 Gene

Aliases for ZBTB41 Gene

  • Zinc Finger And BTB Domain Containing 41 2 3 5
  • FRBZ1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 41 3
  • FRBZ1 Protein (FRBZ1) 3
  • ZNF924 3

External Ids for ZBTB41 Gene

Previous GeneCards Identifiers for ZBTB41 Gene

  • GC01M193860
  • GC01M195389
  • GC01M197122
  • GC01M168280

Summaries for ZBTB41 Gene

GeneCards Summary for ZBTB41 Gene

ZBTB41 (Zinc Finger And BTB Domain Containing 41) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZBTB41 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB41 Gene

Genomics for ZBTB41 Gene

Regulatory Elements for ZBTB41 Gene

Enhancers for ZBTB41 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G197173 0.9 ENCODE 11.4 +26.3 26311 1.7 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 PAF1 MXD4 PPARG KAT8 ASPM ZBTB41 CRB1 CFHR3
GH01G197178 0.8 ENCODE 11.4 +21.4 21418 0.9 CTCF PKNOX1 BACH1 ZNF384 RAD21 FOXM1 ZNF316 NCOR1 FOXK2 NFE2 ASPM ZBTB41 CRB1 CFHR3
GH01G197269 0.5 FANTOM5 13.6 -68.7 -68673 0.2 POLR2A SMARCA4 EP300 CRB1 ZBTB41 LOC127011 MRPS21P3
GH01G197144 1.1 ENCODE 5 +54.4 54438 3.3 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS KLF13 CFHR3 ZBTB41 ASPM SEPT14P12
GH01G197199 1.1 ENCODE 4.9 -0.6 -646 2.7 FOXA2 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CFHR3 ZBTB41 CRB1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB41 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000017647 242 4601 FOXA2 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ZBTB41 Gene

Chromosome:
1
Start:
197,153,680 bp from pter
End:
197,200,542 bp from pter
Size:
46,863 bases
Orientation:
Minus strand

Genomic View for ZBTB41 Gene

Genes around ZBTB41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB41 Gene

Proteins for ZBTB41 Gene

  • Protein details for ZBTB41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SVQ8-ZBT41_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 41
    Protein Accession:
    Q5SVQ8
    Secondary Accessions:
    • A2RUA8
    • Q6MZT8
    • Q6ZR25
    • Q7Z4T1
    • Q8IZ99

    Protein attributes for ZBTB41 Gene

    Size:
    909 amino acids
    Molecular mass:
    105192 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB41 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB41 Gene

Post-translational modifications for ZBTB41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB41 Gene

Domains & Families for ZBTB41 Gene

Gene Families for ZBTB41 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB41: view

No data available for UniProtKB/Swiss-Prot for ZBTB41 Gene

Function for ZBTB41 Gene

Molecular function for ZBTB41 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB41: view
genes like me logo Genes that share phenotypes with ZBTB41: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB41 Gene

Localization for ZBTB41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB41 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB41 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZBTB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB41: view

Pathways & Interactions for ZBTB41 Gene

SuperPathways for ZBTB41 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB41: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB41 Gene

Transcripts for ZBTB41 Gene

mRNA/cDNA for ZBTB41 Gene

Unigene Clusters for ZBTB41 Gene

Zinc finger and BTB domain containing 41:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB41 Gene

No ASD Table

Relevant External Links for ZBTB41 Gene

GeneLoc Exon Structure for
ZBTB41
ECgene alternative splicing isoforms for
ZBTB41

Expression for ZBTB41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB41 Gene

Protein differential expression in normal tissues from HIPED for ZBTB41 Gene

This gene is overexpressed in Testis (35.3) and Spleen (33.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB41 Gene



Protein tissue co-expression partners for ZBTB41 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB41 Gene:

ZBTB41

SOURCE GeneReport for Unigene cluster for ZBTB41 Gene:

Hs.529439

Evidence on tissue expression from TISSUES for ZBTB41 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZBTB41: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB41 Gene

Orthologs for ZBTB41 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB41 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia ZBTB41 34 35
  • 93.58 (n)
cow
(Bos Taurus)
Mammalia ZBTB41 34 35
  • 91.72 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB41 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb41 34
  • 88.9 (n)
mouse
(Mus musculus)
Mammalia Zbtb41 34 16 35
  • 88.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB41 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB41 34 35
  • 78.75 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB41 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb41 34
  • 67.7 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC573743 34
  • 63.92 (n)
ZBTB41 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7101 35
  • 28 (a)
OneToMany
CG12942 35
  • 10 (a)
OneToMany
CG30020 35
  • 8 (a)
OneToMany
Species where no ortholog for ZBTB41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB41 Gene

ENSEMBL:
Gene Tree for ZBTB41 (if available)
TreeFam:
Gene Tree for ZBTB41 (if available)

Paralogs for ZBTB41 Gene

(387) SIMAP similar genes for ZBTB41 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZBTB41: view

No data available for Paralogs for ZBTB41 Gene

Variants for ZBTB41 Gene

Sequence variations from dbSNP and Humsavar for ZBTB41 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000014055 -- 197,183,434(+) AAAGT(C/G)TTCTA intron-variant
rs1000146916 -- 197,153,219(+) TAAAA(C/T)AGAGA downstream-variant-500B
rs1000150979 -- 197,183,650(+) TATCC(A/C/G)CAGAT intron-variant
rs1000289961 -- 197,154,041(+) AATGC(C/T)CAGTT nc-transcript-variant, utr-variant-3-prime
rs1000299612 -- 197,168,924(+) TACAA(A/G)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB41 Gene

Variant ID Type Subtype PubMed ID
esv2445525 CNV deletion 19546169
esv2758990 CNV gain+loss 17122850
esv3588492 CNV loss 21293372
esv3588493 CNV loss 21293372
nsv1068409 CNV deletion 25765185
nsv1145390 CNV deletion 24896259
nsv528460 CNV gain 19592680
nsv548871 CNV loss 21841781

Variation tolerance for ZBTB41 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB41 Gene

Human Gene Mutation Database (HGMD)
ZBTB41
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB41 Gene

Disorders for ZBTB41 Gene

Relevant External Links for ZBTB41

Genetic Association Database (GAD)
ZBTB41
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB41

No disorders were found for ZBTB41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB41 Gene

Publications for ZBTB41 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung S.A. … Langefeld C.D. (J. Am. Soc. Nephrol. 2014) 3 64
  5. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. (PMID: 23381943) Williams F.M. … . (Ann. Neurol. 2013) 3 64

Products for ZBTB41 Gene

Sources for ZBTB41 Gene

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