ZBTB40 Gene
protein-coding GIFtS: 52
GCID: GC01P022778
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|
zinc finger and BTB domain containing 40
| |
Aliases
for ZBTB40 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 401 2 | | KIAA04781 3 5 | | ZNF9231 2 | | Zinc Finger And BTB Domain-Containing Protein 402 |
Export aliases for ZBTB40 gene to outside databasesPrevious GC identifers: GC01P022524 GC01P022650 GC01P021021 |
Summaries
for ZBTB40 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT40_HUMAN, Q9NUA8Function: May be involved in transcriptional regulation
Gene Wiki entry for ZBTB40
|
Genomic Views
for ZBTB40 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB40 gene promoter:
Pax-6 Meis-1b MEF-2A Max ARP-1 aMEF-2 Meis-1a TGIF Meis-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB40
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB40 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36ZBTB40 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P022778: view genomic region
(about GC identifiers)
Start:
|
22,778,344 bp from pter |
End:
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22,857,650 bp from pter |
Size:
|
79,307 bases |
Orientation:
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plus strand |
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Proteins
for ZBTB40 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT40_HUMAN, Q9NUA8 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 40 Size: 1239 amino acids; 138118 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA32323.2; Type=Erroneous initiation;
Secondary accessions: O75066 Q5TFU5 Q8N1R1Alternative splicing: 2 isoforms: Q9NUA8-1 Q9NUA8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZBTB40: NX_Q9NUA8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NUA8
ZBTB40 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001077090.1 NP_055685.3
ENSEMBL proteins: ENSP00000364798 ENSP00000383098 ENSP00000384527 ENSP00000363782
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ZBTB40 for ontologies About GeneDecksing
ZBTB40 Antibody Products:
Assay Products for ZBTB40: |
Protein
Domains /
Families
for ZBTB40 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB40 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9NUA8ProtoNet protein and cluster: Q9NUA8 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT40_HUMAN, Q9NUA8Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 12 C2H2-type zinc fingers |
Function
for ZBTB40 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT40_HUMAN, Q9NUA8Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB40 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB40 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZBTB40 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB40 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB40 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZBTB40 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZBTB40 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB40
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for ZBTB40 (Q9NUA82, 3 ENSP000003647984) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
ZBTB40 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB40 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB40
Search CenterWatch for drugs/clinical trials and news about ZBTB40 / ZBT40
|
Transcripts
for ZBTB40 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB40 gene (2 alternative transcripts): NM_001083621.1 NM_014870.3 Unigene Cluster for ZBTB40: Zinc finger and BTB domain containing 40 Hs.418966 [show with all ESTs]Unigene Representative Sequence: NM_0010836214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375647(uc001bfv.1) ENST00000400239 ENST00000404138(uc001bft.2 uc001bfu.2 uc009vqi.1)
ENST00000374651
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB40 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB40 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZBTB40 (NM_014870) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB40 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB40 |
Additional cDNA sequence: AB007947.2 AK091019.1 AK314747.1 BC114607.1 9 DOTS entries: DT.95369508 DT.121449984 DT.97817884 DT.40288549 DT.40313275 DT.121449977 DT.121449982 DT.91732579 DT.97789834 24/148 AceView cDNA sequences (see all 148): BQ017023 BU186485 BM972562 AI239517 CB852809 BM677778 BQ184857 N90703 BM987504 AI094761 AK095273 AA806623 CD626263 BM722197 BX113705 BM719972 AI628678 BE326296 AW592033 AA678823 BM715561 AL603138 CA422875 BE503066
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB40 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|
|
| SP1: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZBTB40
|
Expression
for ZBTB40 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB40 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTACAGGGC
About this image
See ZBTB40 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB40
SOURCE GeneReport for Unigene cluster: Hs.418966
SABiosciences Custom PCR Arrays for ZBTB40
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB40
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB40 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB40 |
Orthologs
for ZBTB40 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB40 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for ZBTB40 (if available)
TreeFam Gene Tree for ZBTB40 (if available) |
Paralogs
for ZBTB40 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZBTB40 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB40 (22778344 - 22857650 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZBTB40
1 Indel: 58364
Human Gene Mutation Database (HGMD): ZBTB40
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB40 |
|
Disorders
/ Diseases
for ZBTB40 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBTB40 for disorders About GeneDecksing
OMIM gene information: 612106
OMIM disorders: --
1  disease for ZBTB40: About MalaCardsosteoporosis
Human Genome Epidemiology (HuGE) Navigator: ZBTB40 (5 documents)
Export disorders for ZBTB40 gene to outside databases
|
Publications
for ZBTB40 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB40 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with ZBTB40) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)1, 2 Matsuoka S.... Elledge S.J. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
- Opposite associations of osteoprotegerin and ZBTB40 po lymorphisms with bone mineral density of the hip in postmenopausal Taiwanese wom en. (PubMed id 22824048)1 Chao T.H....Lu K.H. (2012)
- Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture ri sk. (PubMed id 21533022)1 Duncan E.L....Brown M.A. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Analysis of recently identified osteoporosis suscepti bility genes in Han Chinese women. (PubMed id 20554715)1 Liu J.M....Ning G. (2010)
|
External Searches for ZBTB40 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB40 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB40 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZBTB40 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB40 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB40 gene:
Search GeneIP for patents involving ZBTB40
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB40 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZBTB40 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBTB40 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB40 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZBTB40 | | OriGene 3'-UTR Clone for ZBTB40 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB40 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB40 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZBTB40 | | OriGene Custom Protein Services for ZBTB40 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBTB40 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB40 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB40 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB40 |
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| | | | Search Tocris compounds for ZBTB40 |
| |  |  |  |  | | | | |
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 | | | ZBTB40 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB40 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZBTB40 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB40 |
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