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Aliases for ZBTB40 Gene

Aliases for ZBTB40 Gene

  • Zinc Finger And BTB Domain Containing 40 2 3
  • KIAA0478 4 6
  • Zinc Finger And BTB Domain-Containing Protein 40 3
  • ZNF923 3

External Ids for ZBTB40 Gene

Previous GeneCards Identifiers for ZBTB40 Gene

  • GC01P022524
  • GC01P022650
  • GC01P022778
  • GC01P021021

Summaries for ZBTB40 Gene

GeneCards Summary for ZBTB40 Gene

ZBTB40 (Zinc Finger And BTB Domain Containing 40) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZBTB40 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZBTB40 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB40 Gene

Genomics for ZBTB40 Gene

Regulatory Elements for ZBTB40 Gene

Genomic Location for ZBTB40 Gene

Start:
22,451,851 bp from pter
End:
22,531,157 bp from pter
Size:
79,307 bases
Orientation:
Plus strand

Genomic View for ZBTB40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB40 Gene

Proteins for ZBTB40 Gene

  • Protein details for ZBTB40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUA8-ZBT40_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 40
    Protein Accession:
    Q9NUA8
    Secondary Accessions:
    • O75066
    • Q5TFU5
    • Q8N1R1

    Protein attributes for ZBTB40 Gene

    Size:
    1239 amino acids
    Molecular mass:
    138118 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32323.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBTB40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB40 Gene

Proteomics data for ZBTB40 Gene at MOPED

Post-translational modifications for ZBTB40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB40 Gene

No data available for DME Specific Peptides for ZBTB40 Gene

Domains for ZBTB40 Gene

Gene Families for ZBTB40 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZBTB40 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUA8

UniProtKB/Swiss-Prot:

ZBT40_HUMAN :
  • Q9NUA8
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB40: view

Function for ZBTB40 Gene

Molecular function for ZBTB40 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZBTB40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB40: view

Animal Model Products

CRISPR Products

miRNA for ZBTB40 Gene

miRTarBase miRNAs that target ZBTB40

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB40

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB40 Gene

Localization for ZBTB40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB40 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB40 Gene COMPARTMENTS Subcellular localization image for ZBTB40 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZBTB40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15302935
genes like me logo Genes that share ontologies with ZBTB40: view

Pathways for ZBTB40 Gene

SuperPathways for ZBTB40 Gene

No Data Available

Interacting Proteins for ZBTB40 Gene

Gene Ontology (GO) - Biological Process for ZBTB40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 17525332
GO:0030282 bone mineralization NAS 20554715
genes like me logo Genes that share ontologies with ZBTB40: view

No data available for Pathways by source for ZBTB40 Gene

Transcripts for ZBTB40 Gene

Unigene Clusters for ZBTB40 Gene

Zinc finger and BTB domain containing 40:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB40

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZBTB40

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB40 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - -
SP2: -
SP3:
SP4:

Relevant External Links for ZBTB40 Gene

GeneLoc Exon Structure for
ZBTB40
ECgene alternative splicing isoforms for
ZBTB40

Expression for ZBTB40 Gene

mRNA expression in normal human tissues for ZBTB40 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB40 Gene

SOURCE GeneReport for Unigene cluster for ZBTB40 Gene Hs.418966

genes like me logo Genes that share expressions with ZBTB40: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB40 Gene

Orthologs for ZBTB40 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB40 35
  • 99.19 (n)
  • 98.55 (a)
ZBTB40 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB40 35
  • 85.98 (n)
  • 84.09 (a)
ZBTB40 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB40 35
  • 88.32 (n)
  • 86.36 (a)
ZBTB40 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb40 35
  • 82.08 (n)
  • 79.89 (a)
Zbtb40 16
Zbtb40 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB40 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB40 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb40 35
  • 82.26 (n)
  • 80.16 (a)
chicken
(Gallus gallus)
Aves ZBTB40 35
  • 69.22 (n)
  • 64.93 (a)
ZBTB40 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb40 35
  • 62.98 (n)
  • 57.03 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC571158 35
  • 52.23 (n)
  • 41.25 (a)
ZBTB40 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10321 36
  • 19 (a)
OneToOne
Species with no ortholog for ZBTB40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB40 Gene

ENSEMBL:
Gene Tree for ZBTB40 (if available)
TreeFam:
Gene Tree for ZBTB40 (if available)

Paralogs for ZBTB40 Gene

genes like me logo Genes that share paralogs with ZBTB40: view

No data available for Paralogs for ZBTB40 Gene

Variants for ZBTB40 Gene

Sequence variations from dbSNP and Humsavar for ZBTB40 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2053 -- 22,499,475(-) AATGC(C/T)TTTTC intron-variant
rs104861 -- 22,518,458(-) CTTGT(C/G)ACCaa intron-variant
rs169711 -- 22,522,769(+) ttttt(A/T)ttttt intron-variant
rs182355 -- 22,509,540(+) acggg(A/G)tttcg intron-variant
rs209719 -- 22,521,059(-) GGGGC(A/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB40 Gene

Variant ID Type Subtype PubMed ID
nsv6298 CNV Loss 18451855
nsv506921 CNV Insertion 20534489
nsv819803 CNV Gain 19587683

Relevant External Links for ZBTB40 Gene

HapMap Linkage Disequilibrium report
ZBTB40
Human Gene Mutation Database (HGMD)
ZBTB40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB40 Gene

Disorders for ZBTB40 Gene

Relevant External Links for ZBTB40

Genetic Association Database (GAD)
ZBTB40
Human Genome Epidemiology (HuGE) Navigator
ZBTB40
genes like me logo Genes that share disorders with ZBTB40: view

No data available for UniProtKB/Swiss-Prot for ZBTB40 Gene

Publications for ZBTB40 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S. … Elledge S.J. (Science 2007) 3 4
  5. Multiple genetic loci for bone mineral density and fractures. (PMID: 18445777) Styrkarsdottir U. … Stefansson K. (N. Engl. J. Med. 2008) 3 48

Products for ZBTB40 Gene

  • antibodies-online peptides for ZBTB40
  • antibodies-online antibodies for ZBTB40
  • antibodies-online kits for ZBTB40

Sources for ZBTB40 Gene

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