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ZBTB40 Gene

protein-coding   GIFtS: 54

GC01P022650
zinc finger and BTB domain containing 40
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for ZBTB40

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
KIAA0478 1, 2, 3, 5
MGC133098 2
Descriptions
zinc finger and BTB domain containing 40 2
External Ids
HGNC: 290451
Entrez Gene: 99232
UniProtKB: Q9NUA83
Ensembl: ENSG000001846777
Search outside databases for aliases for ZBTB40 gene

Previous GC identifer: GC01P022524

Summaries
for ZBTB40

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT40_HUMAN, Q9NUA8
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZBTB40

Genomic Location
for ZBTB40

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB40 gene  

Entrez Gene cytogenetic band: 1pter-q31.3   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36

ZBTB40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P022650:     (about GC identifiers)

Start:
 22,650,931 bp from pter
End:
 22,730,237 bp from pter
Size:
 79,307 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000001.9  NT_004610.18  

Proteins
for ZBTB40

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ZBT40_HUMAN, Q9NUA8 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 40  
Size: 1239 amino acids; 138118 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: O75066 Q5TFU5 Q8N1R1
Alternative splicing: 2 isoforms:  Q9NUA8-1   Q9NUA8-2   

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001077090.1  NP_055685.3  


    ENSEMBL proteins: 
    ENSP00000363780 ENSP00000364798 ENSP00000383098 ENSP00000363782 ENSP00000384527 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZBTB40: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ZBTB40

    Assays for ZBTB40: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ZBTB40

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro domains/families (see all 6 ):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ


       GeneDecks  ZBTB40 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9NUA8

    ProtoNet protein and cluster: Q9NUA8

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT40_HUMAN, Q9NUA8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 12 C2H2-type zinc fingers

    Gene Function
    for ZBTB40

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ZBTB40)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB40)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001083621

                  Applied Biosystems Silencer® siRNAs for ZBTB40

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB40  
                         Sigma-Aldrich shRNA for ZBTB40  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001083621
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001083621
                                     untagged cDNA clones in CMV expression vector (see all 4): AK091019 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001083621

    UniProtKB/Swiss-Prot: ZBT40_HUMAN, Q9NUA8
    Function: May be involved in transcriptional regulation

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for ZBTB40

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for ZBTB40 (ENSP000003637823) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF11AENSP000002694853STRING (score=.762)
    TNFRSF11BENSP000002973503STRING (score=.745)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table

    Drugs & Compounds
    for ZBTB40

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB40

    Transcripts
    for ZBTB40

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ZBTB40)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB40)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001083621

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB40  
                         Sigma-Aldrich shRNA for ZBTB40  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001083621  NM_014870  

    REFSEQ mRNAs for ZBTB40 gene (2 alternative transcripts): 

    NM_001083621.1   NM_014870.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001083621  NM_014870  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001083621
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001083621
                                     untagged cDNA clones in CMV expression vector (see all 4): AK091019 

    Additional cDNA sequence: 

    AB007947.2 AK091019.1 AK314747.1 BC114607.1 

    9 DOTS entries:

    DT.95369508  DT.121449984  DT.97817884  DT.40288549  DT.40313275  DT.121449977  DT.121449982  DT.91732579 
    DT.97789834 

    24/148 AceView cDNA sequences (see all 148 ):

    CA422875 NM_014870 BE503066 AW592033 CD671842 BQ017023 AA678823 BM972562 
    AI239517 AI933487 AW103160 BQ184857 BM987504 BU186485 BM677778 CB852809 
    N90703 AI862529 BM674019 BM719972 BQ925357 CD671843 CD626263 AK095273 

    highest scoring ESTs for ZBTB40:

    AB007947 AA033895 AA033948 AA090999 AA281834 AA356346 AA404992 AA554134 AA678823 AA723116 

    Unigene Cluster for ZBTB40:

    Zinc finger and BTB domain containing 40
    Hs.418966  [show with all ESTs]
    Unigene Representative Sequence: NM_001083621


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB40

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:              -                       -                                                           -     -                                 
    SP2:                                      -                                                                                                   
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          

    About this scheme

    ECgene alternative splicing isoforms for ZBTB40

    5 Ensembl transcripts including schematic representations:
    ENST00000374649  ENST00000375647  ENST00000400239  ENST00000374651  ENST00000404138  

    Expression
    for ZBTB40

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB40 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB40

    1 / 2 / 3

    6 probe-sets matching ZBTB40 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35990_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB007947 1.00 1.00 1.00 1

    		203959_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014870 0.60 1.00 0.82 1

    		203958_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI557467 0.60 1.00 0.82 1

    		203959_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		203958_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1559728_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ZBTB40 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTTACAGGGC

    SOURCE GeneReport for Unigene cluster: Hs.418966

    Expression variation in blood from EXPOLDB for ZBTB40

    Orthologs
    for ZBTB40

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ZBTB40 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ZBTB401   -- zinc finger and BTB domain containing 40 88.32(n)
    86.36(a)    		 487384  XM_544510.2  XP_544510.2 
    chimpanzee
    (Pan troglodytes)    		 ZBTB401   -- zinc finger and BTB domain containing 40 99.19(n)
    98.55(a)    		 456610  XM_513186.2  XP_513186.2 
    cow
    (Bos taurus)    		 ZBTB401   -- zinc finger and BTB domain containing 40 85.98(n)
    84.09(a)    		 534714  XM_614579.3  XP_614579.2 
    rat
    (Rattus norvegicus)    		 Zbtb401   -- zinc finger and BTB domain containing 40 82.26(n)
    80.16(a)    		 362635  XM_342953.3  XP_342954.3 
    mouse
    (Mus musculus)    		 Zbtb401, 5 45
    		 zinc finger and BTB domain containing 401, 5 82.08(n)1
    79.89(a)1    		 2308481  NM_198248.11  NP_937891.11 
     AA5476505  AI4506245  (see all 14)
    About this table        Species with no ortholog for ZBTB40

    ENSEMBL Gene Tree for ZBTB40

    Paralogs
    for ZBTB40

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for ZBTB40

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/362 NCBI SNPs in ZBTB40 are shown (see all 362 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 120)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs2097291,2
    		A,C,F,H,O22708264(-) GCTTGC/TACTCA 2 Y/C mis1 ese316Minor allele frequency- N:0.00EA NA EU WA 1184
    rs22813551,2
    		C,F,H,O22725491(-) TCTGCC/TGGATG 2 -- ut31 ese312Minor allele frequency- T:0.33EA NA EU WA 2440
    rs46550641,2
    		A,C,F,H22651043(+) TATGGC/AGCTGT 2 -- ut51 ese312Minor allele frequency- A:0.37EU EA WA NA 1052
    rs22813541,2
    		A,C,F,H22725728(-) GAGGCC/TGCAGC 2 -- ut31 ese39Minor allele frequency- T:0.29EA EU WA 2136
    rs10626631,2
    		A,C,F,H22729188(+) ATGTAT/CAGAGT 2 -- ut31 ese316Minor allele frequency- C:0.34EA NA EU WA 1472
    rs107374661,2
    		C,F,H22651746(+) AAAGTC/TTACTG 2 -- ut51 int14Minor allele frequency- T:0.03EU EA WA 412
    rs124061941,2
    		C,F,H22728926(+) ATCGGG/AGCTGA 2 -- ut314Minor allele frequency- A:0.04EU EA WA 412
    rs66592221,2
    		C,F,H22689701(+) GTGAGG/ACAAAG 2 T/A mis1 ese38Minor allele frequency- A:0.00EU EA WA 826
    rs22358841,2
    		F,H,O22728453(-) GGGGAC/GCCACC 2 -- ut31 ese35Minor allele frequency- G:0.06EA EU WA 1898
    rs9628891,2
    		C,F,H22729839(+) GGCCAG/ATGTCA 2 -- ut31 ese35Minor allele frequency- A:0.39MN EU EA WA 592
    About this table

    HapMap Linkage Disequilibrium images for ZBTB40 (up to first 250kb)

    Disorders & Mutations
    for ZBTB40

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 612106

    Human Genome Epidemiology Navigator: ZBTB40 (1 document)

    Medical News
    for ZBTB40

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ZBTB40

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/11 PubMed articles for ZBTB40 gene (see all 11 ):

    Search for ZBTB40

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZBTB40

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 9923 HGNC: 29045 AceView: KIAA0478 Ensembl:ENSG00000184677 euGenes: HUgn9923
    ECgene: ZBTB40 H-InvDB: ZBTB40

    Other Databases showing ZBTB40

    (According to HUGE)
    About This Section
    HUGE: KIAA0478

    Specialized Databases showing ZBTB40

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for ZBTB40

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ZBTB40

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB40:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB40-related products

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     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ZBTB40 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZBTB40 Browse small molecules at Sigma-Aldrich
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