ZBTB4 Gene

Aliases
for ZBTB4 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC17M007563 GC17M007303

Summaries
for ZBTB4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZBTB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10  NT_010718.17  NC_018928.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZBTB4 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB4

ZBTB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007362:  view genomic region     (about GC identifiers)

Proteins
for ZBTB4 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ZBTB4: NX_Q9P1Z0

Explore proteomics data for ZBTB4 at MOPED

Post-translational modifications: 

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Domains /
Families
for ZBTB4 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9P1Z0

Find genes that share domains with ZBTB4           About GenesLikeMe

Function
for ZBTB4 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

genOway: Develop your customized and physiologically relevant rodent model for ZBTB4

miRNA Products:		miRTarBase miRNAs that target ZBTB4: hsa-mir-30d-5p (MIRT047828), hsa-mir-19b-3p (MIRT031203), hsa-mir-652-3p (MIRT039514), hsa-mir-122-5p (MIRT023262), hsa-mir-454-3p (MIRT039221), hsa-mir-130b-3p (MIRT020226), hsa-mir-331-3p (MIRT043490), hsa-mir-1226-3p (MIRT036449), hsa-mir-99a-5p (MIRT048706), hsa-mir-181b-5p (MIRT047283), hsa-mir-615-3p (MIRT039695), hsa-mir-186-5p (MIRT044958)
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		hsa-miR-631 hsa-miR-199a-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-519a hsa-miR-342-3p hsa-miR-93 hsa-miR-130b
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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4

Localization
for ZBTB4 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	3
cytosol	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for ZBTB4 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 4 biological process terms:    About this table

Drugs & Compounds
for ZBTB4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZBTB4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZBTB4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZBTB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTCCCTGGGA

About this image

Heart (Cardiovascular System)
Cushion Mesenchymal Cells Endocardium
Blood (Hematopoietic System)
Hematopoietic Stem Cells Hematopoietic Bone Marrow

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4

Orthologs
for ZBTB4 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZBTB4 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ZBTB4 gene

ZBTB21²  ZBTB38²  ZBTB33²  ZBTB14²  ZBTB7C²  ZBTB7A²  ZBTB7B²  

Selected SIMAP similar genes for ZBTB4 using alignment to 2 protein entries:     ZBTB4_HUMAN (see all proteins) (see all similar genes):

KLHL36    ZBTB21    ZBTB3    ZNF295    HIC1    KLHL2

ZBTB38    ZBTB17    ZBTB7C    KLHL32    ZBTB16    ZBTB20

ZBTB25    KLHL18    MYNN    ZBTB49    NACC1    ZBTB45

Find genes that share paralogs with ZBTB4           About GenesLikeMe

Genomic Variants
for ZBTB4 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZBTB4 (see all 462)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1922276641,2		--	7255720(+)	CCCTCC/TGTAAC	1	--	int1		0	--	--	--	--
rs177328781,2	C,F,H	--	7255804(+)	TCTTAT/CGGCCA	1	--	int1		21		NA NS EA WA	2366
rs1857619131,2		--	7255948(+)	GATGTG/TGGGCC	1	--	int1		0	--	--	--	--
rs1136154331,2	C,F	--	7255959(+)	AAAGTC/TAGCTT	1	--	int1		1		NA	2
rs1478797021,2	C	--	7256085(+)	CTTTCC/TCCCAG	1	--	int1		0	--	--	--	--
rs1414938771,2		--	7256113(+)	ATAATC/TGCACC	1	--	int1		0	--	--	--	--
rs753451101,2	C,F	--	7256311(+)	CTCTGC/TCACCA	1	--	ut31		1		WA	118
rs1891828681,2		--	7256458(+)	ATATTG/TTAATC	1	--	ut31		0	--	--	--	--
rs92171,2	C,F,O,A,H	--	7256533(-)	CTTAAA/GTATGA	1	--	ut31		33		MN EA NA NS WA CSA	3176
rs124535721,2	C,F,H	--	7256553(+)	ATGTCT/AACAAT	1	--	ut31 ese3		5		NS EA NA	414

HapMap Linkage Disequilibrium report for ZBTB4 (7362685 - 7387582 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for ZBTB4:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2422288	CNV	Deletion	17116639
dgv3054n71	CNV	Loss	21882294
nsv457659	CNV	Loss	19166990
nsv523672	CNV	Loss	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZBTB4

DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB4

Disorders / Diseases
for ZBTB4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ZBTB4 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. (PubMed id 19448668)^{1, 2} Yamada D.... Defossez P.A. (Oncogene 2009)
2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (DNA Res. 2000)
5. A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PubMed id 16354688)^{1, 9} Filion G.J....Defossez P.A. (Mol. Cell. Biol. 2006)
6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
7. Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. (PubMed id 21765466)¹ Kim K....Safe S. (Oncogene 2012)
8. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)¹ Tatham M.H....Hay R.T. (Sci Signal 2011)
9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (Sci. Signal. 2010)
10. Identification of DeltaNp63alpha protein interactions by mass spectrometry. (PubMed id 20085233)¹ Amoresano A....CalabrA^ V. (J. Proteome Res. 2010)

External Searches for ZBTB4 gene

Genome Databases showing ZBTB4 gene

Other Databases showing ZBTB4 gene

Specialized Databases showing ZBTB4 gene

Products
for ZBTB4 gene

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Advanced Cell Diagnostics, Animal models from genOway)
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