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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZBTB4 Gene

protein-coding GIFtS: 48
GCID: GC17M007362

zinc finger and BTB domain containing 4

Search for ZBTB4
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 4¹ ²
KAISO-L1¹ ² ³
KIAA1538¹ ³ ⁵
ZNF903¹ ²
KAISO-Like Zinc Finger Protein 1² ³
Zinc Finger And BTB Domain-Containing Protein 4²

External Ids:	HGNC: 23847¹	Entrez Gene: 57659²	Ensembl: ENSG00000174282⁷	OMIM: 612308⁵	UniProtKB: Q9P1Z0³

Export aliases for ZBTB4 gene to outside databases

Previous GC identifers: GC17M007563 GC17M007303

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZBTB4 gene promoter:
GR TBP HOXA5 HNF-4alpha2 GR-alpha Ik-3 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZBTB4 promoter sequence

Search SABiosciences Chromatin IP Primers for ZBTB4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.2

ZBTB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB4 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M007362: view genomic region (about GC identifiers)

Start:	7,362,685 bp from pter	End:	7,387,582 bp from pter
Size:	24,898 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 4

Size: 1013 amino acids; 105114 Da

Subunit: Interacts with HIPK2

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=BAA96062.2; Type=Erroneous initiation;

Secondary accessions: B3KVL6 Q7Z697 Q86XJ4 Q8N4V8

Explore the universe of human proteins at neXtProt for ZBTB4: NX_Q9P1Z0

Post-translational modifications:

Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to

DNA damage¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P1Z0

ZBTB4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001122305.1 NP_065950.2

ENSEMBL proteins:

ENSP00000369973 ENSP00000307858

Human Recombinant Protein Products for ZBTB4:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ZBTB4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZBTB4 for ontologies About GeneDecksing

ZBTB4 Antibody Products:

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	GenScript Custom Assay Services for ZBTB4
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	Uscn ELISAs and CLIAs for ZBTB4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZBTB4 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR015880 Znf_C2H2-like

IPR011333 BTB/POZ_fold

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR013069 BTB_POZ

IPR000210 BTB/POZ-like

Graphical View of Domain Structure for InterPro Entry Q9P1Z0

ProtoNet protein and cluster: Q9P1Z0

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 6 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZBTB4_HUMAN, Q9P1Z0

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZBTB4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ZBTB4:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZBTB4

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ZBTB4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZBTB4
		8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB4 (see all 72):
		hsa-miR-631 hsa-miR-199a-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-519a hsa-miR-342-3p hsa-miR-93 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: ZBTB4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBTB4 (see all 4) OriGene shRNA RFP: ZBTB4 OriGene siRNA: ZBTB4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB4 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZBTB4 (NM_005341)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ZBTB4
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		Sirion Biotech Customized stable knockdown cell line services for ZBTB4 Sirion Biotech Customized inducible knockdown cell line services for ZBTB4 Sirion Biotech Customized stable overexpressing cell line services for ZBTB4 Sirion Biotech Customized inducible overexpressing cell line services for ZBTB4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ZBTB4

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for ZBTB4 (Q9P1Z0³ ENSP00000307858⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SIN3B	O75182³, ENSP00000369131⁴	I2D: score=1 STRING: ENSP00000369131
PIAS2	O75928³, ENSP00000381648⁴	I2D: score=1 STRING: ENSP00000381648
SIN3A	Q96ST3³, ENSP00000353622⁴	I2D: score=1 STRING: ENSP00000353622
TP63	ENSP00000264731⁴	STRING: ENSP00000264731
SUMO2	ENSP00000405965⁴	STRING: ENSP00000405965

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZBTB4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZBTB4
Search CenterWatch for drugs/clinical trials and news about ZBTB4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZBTB4 gene (2 alternative transcripts):

NM_001128833.1 NM_020899.3

Unigene Cluster for ZBTB4:

Zinc finger and BTB domain containing 4

Hs.35096 [show with all ESTs]

Unigene Representative Sequence: NM_020899

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380599(uc002ghc.4) ENST00000311403(uc002ghd.4)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ZBTB4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZBTB4
		8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB4 (see all 72):
		hsa-miR-631 hsa-miR-199a-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-519a hsa-miR-342-3p hsa-miR-93 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: ZBTB4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBTB4 (see all 4) OriGene shRNA RFP: ZBTB4 OriGene siRNA: ZBTB4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB4
		Sirion Biotech Custom design and validation of potent shRNA sequences against ZBTB4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB4 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZBTB4 (NM_005341)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ZBTB4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB4

Additional cDNA sequence:

AB040971.2 AK027143.1 AK122826.1 AK122971.1 AY302699.1 BC015902.1 BC033259.1 BC043352.2

BC131774.1

10 DOTS entries:

DT.100819620 DT.456393 DT.99957914 DT.91882042 DT.120976070 DT.304966 DT.95195736 DT.95285201

DT.95305021 DT.75156238

24/273 AceView cDNA sequences (see all 273):

BM697291 CB306760 BX491712 AB040971 AI203137 AI198133 AK122826 CA395952

BM692980 BU161722 AI144539 BM703239 AY302699 W37794 BC033259 AI669498

BM668322 BM664727 BQ880799 AI185028 AA617772 BU620047 BM563262 BM987036

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZBTB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCCTGGGA

About this image

ZBTB4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Endocardial Tube Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZBTB4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB4

SOURCE GeneReport for Unigene cluster: Hs.35096

SABiosciences Custom PCR Arrays for ZBTB4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB4 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ZBTB4⁶	--	44(a)	1 ↔ 1	GL343660.1(198450-202067)
zebrafish (Danio rerio)	Actinopterygii	zbtb4⁶	zinc finger and BTB domain containing 4	20(a)	1 ↔ 1	12(23884382-23896562)

ENSEMBL Gene Tree for ZBTB4 (if available)
TreeFam Gene Tree for ZBTB4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZBTB4 gene

ZBTB21² ZBTB38² ZBTB33²

18/27 SIMAP similar genes for ZBTB4 using alignment to 2 protein entries: ZBTB4_HUMAN (see all proteins) (see all similar genes):

KLHL36 ZBTB21 ZBTB3 ZNF295 HIC1 KLHL2

ZBTB10 ZBTB38 ZBTB17 ZBTB7C KLHL32 ZBTB16

ZBTB20 ZBTB25 KLHL18 MYNN ZBTB49 NACC1

ZBTB4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17732878^1,2	C,F,H	--	7255804(+)	`TCTTAT/CGGCCA`	1	--	int¹		21		NA NS EA WA	2366
rs113615433^1,2	C	--	7255959(+)	`AAAGTC/TAGCTT`	1	--	int¹		1		NA	2
rs75345110^1,2	C,F	--	7256311(+)	`CTCTGC/TCACCA`	1	--	ut3¹		1		WA	118
rs12453572^1,2	C,F,H	--	7256553(+)	`ATGTCT/AACAAT`	1	--	ut3¹ ese³		5		NS EA NA	414
rs34055023^1,2	C,F	--	7256918(+)	`CCCCCC/GCTTAA`	1	--	ut3¹		3		NA EA	124
rs111690305^1,2		--	7258468(+)	`CCCCTC/GATGGA`	1	--	ut3¹		0	--	--	--	--
rs112678232^1,2		--	7259326(+)	`GCCAGC/TGCTGC`	2	T A	mis¹		1		CSA	2
rs35376727^1,2	F	--	7259376(-)	`TGCTGA/G/TGCGGC`	3	E G V	mis¹		1		NA	38
rs34739055^1,2	C	--	7261126(+)	`TGAGG-/TTGCAG`	1	--	int¹		1		NA	2
rs34809908^1,2	C,F	--	7261271(+)	`AGCAGG/AGNNNN`	1	--	int¹		6		NA WA CSA	246

HapMap Linkage Disequilibrium report for ZBTB4 (7362685 - 7387582 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBTB4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB4

DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZBTB4 for disorders About MalaCards

ZBTB4 for disorders About GeneDecksing

OMIM gene information: 612308 OMIM disorders: --

Export disorders for ZBTB4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZBTB4 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ZBTB4)

Utopia: connect your pdf to the dynamic
world of online information

The human protein kinase HIPK2 phosphorylates and dow nregulates the methyl-binding transcription factor ZBTB4. (PubMed id 19448668)^{1, 2} Yamada D....Defossez P.A. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (2000)
A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PubMed id 16354688)^{1, 9} Filion G.J....Defossez P.A. (2006)
Identification of oncogenic microRNA-17-92/ZBTB4/speci ficity protein axis in breast cancer. (PubMed id 21765466)¹ Kim K....Safe S. (2012)
Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)¹ Tatham M.H....Hay R.T. (2011)
Sequence-specific recognition of methylated DNA by hu man zinc-finger proteins. (PubMed id 20403812)¹ Sasai N....Defossez P.A. (2010)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)¹ Golebiowski F....Hay R.T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57659	HGNC: 23847	AceView: ZBTB4	Ensembl:ENSG00000174282	euGenes: HUgn57659
ECgene: ZBTB4	H-InvDB: ZBTB4

(According to HUGE)
About This Section

HUGE: KIAA1538

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZBTB4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZBTB4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZBTB4 gene:
Search GeneIP for patents involving ZBTB4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for ZBTB4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBTB4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB4
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	OriGene siRNA for ZBTB4		OriGene 3'-UTR Clone for ZBTB4
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	OriGene Custom Antibody Services for ZBTB4		OriGene Custom Protein Services for ZBTB4
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBTB4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB4
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	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB4

	GenScript Custom Purified and Recombinant Proteins Services for ZBTB4		GenScript cDNA clones with any tag delivered in your preferred vector for ZBTB4
	GenScript Custom Assay Services for ZBTB4		GenScript Custom Superior Antibodies Services for ZBTB4
	GenScript Custom overexpressing Cell Line Services for ZBTB4		CloneReady with Over 120,000 Genes
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	Regulatory tfbs in ZBTB4 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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ZBTB4 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4

	SwitchGear 3'UTR luciferase reporter plasmids for ZBTB4
	SwitchGear Promoter luciferase reporter plasmids for ZBTB4

ThermoFisher Antibodies for ZBTB4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZBTB4

Sirion Biotech Customized:

	stable knockdown cell line services for ZBTB4
	inducible knockdown cell line services for ZBTB4
	design and validation of potent shRNA sequences against ZBTB4
	adenovirus for potent knockdown of ZBTB4
	adenovirus for overexpression of ZBTB4
	stable overexpressing cell line services for ZBTB4
	inducible overexpressing cell line services for ZBTB4

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZBTB4 gene at Home site.

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ZBTB4 Gene

zinc finger and BTB domain containing 4

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ZBTB4 Gene

zinc finger and BTB domain containing 4

Aliasesfor ZBTB4 gene

Summariesfor ZBTB4 gene

Genomic Viewsfor ZBTB4 gene

Proteinsfor ZBTB4 gene

Protein Domains /Familiesfor ZBTB4 gene

Functionfor ZBTB4 gene

Pathways & Interactionsfor ZBTB4 gene

Drugs & Compoundsfor ZBTB4 gene

Transcriptsfor ZBTB4 gene

Expression for ZBTB4 gene

Orthologsfor ZBTB4 gene

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Genomic Variantsfor ZBTB4 gene

Disorders / Diseasesfor ZBTB4 gene

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External Searches for ZBTB4 gene

Genome Databases showing ZBTB4 gene

Other Databases showing ZBTB4 gene

Specialized Databases showing ZBTB4 gene

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Aliases
for ZBTB4 gene

Summaries
for ZBTB4 gene

Genomic Views
for ZBTB4 gene

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for ZBTB4 gene

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Families
for ZBTB4 gene

Function
for ZBTB4 gene

Pathways & Interactions
for ZBTB4 gene

Drugs & Compounds
for ZBTB4 gene

Transcripts
for ZBTB4 gene

Expression
for ZBTB4 gene

Orthologs
for ZBTB4 gene

Paralogs
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Genomic Variants
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Disorders / Diseases
for ZBTB4 gene

Publications
for ZBTB4 gene

Intellectual Property
for ZBTB4 gene

Products
for ZBTB4 gene