Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB4 Gene

protein-coding   GIFtS: 49
GCID: GC17M007362

Zinc Finger And BTB Domain Containing 4
  See related disease
at
MalaCards
 

Aliases
for ZBTB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Zinc Finger And BTB Domain Containing 41 2
KAISO-L12 3
KAISO-Like Zinc Finger Protein 12 3
KIAA15383 5
ZNF9032
Zinc Finger And BTB Domain-Containing Protein 42

External Ids:    HGNC: 238471   Entrez Gene: 576592   Ensembl: ENSG000001742827   OMIM: 6123085   UniProtKB: Q9P1Z03   

Export aliases for ZBTB4 gene to outside databases

Previous GC identifers: GC17M007563 GC17M007303


Summaries
for ZBTB4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for ZBTB4 Gene: 
ZBTB4 (zinc finger and BTB domain containing 4) is a protein-coding gene. Diseases associated with ZBTB4 include breast cancer. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZBTB38.

UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0
Function: May be involved in transcriptional regulation




Genomic Views
for ZBTB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB4 gene promoter:
         GR   TBP   HOXA5   HNF-4alpha2   GR-alpha   Ik-3   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZBTB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

ZBTB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007362:  view genomic region     (about GC identifiers)

Start:
 7,362,685 bp from pter      End:
 7,387,582 bp from pter
Size:
 24,898 bases      Orientation:
 minus strand

Proteins
for ZBTB4 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 4  
Size: 1013 amino acids; 105114 Da
Subunit: Interacts with HIPK2
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA96062.2; Type=Erroneous initiation;
Secondary accessions: B3KVL6 Q7Z697 Q86XJ4 Q8N4V8

Explore the universe of human proteins at neXtProt for ZBTB4: NX_Q9P1Z0

Explore proteomics data for ZBTB4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response
    to DNA damage
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P1Z0

    • ZBTB4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBTB4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001122305.1  NP_065950.2  

    ENSEMBL proteins: 
     ENSP00000369973   ENSP00000307858  

    Human Recombinant Protein Products for ZBTB4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ZBTB4
    GenScript Custom Purified and Recombinant Proteins Services for ZBTB4
    Novus Biologicals ZBTB4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZBTB4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZBTB4 for ontologies           About GeneDecksing



    ZBTB4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZBTB4
    GenScript Custom Superior Antibodies Services for ZBTB4
    Novus Biologicals ZBTB4 Antibody
    Abcam antibodies for ZBTB4
    Cloud-Clone Corp. Antibodies for ZBTB4 
    ThermoFisher Antibodies for ZBTB4
    LSBio Antibodies in human, mouse, rat for ZBTB4 

    Assay Products for ZBTB4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZBTB4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZBTB4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZBTB4 
    Cloud-Clone Corp. CLIAs for ZBTB4

    Protein Domains /
    Families
    for ZBTB4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q9P1Z0

    ProtoNet protein and cluster: Q9P1Z0

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 C2H2-type zinc fingers


    ZBTB4 for domains           About GeneDecksing


    Function
    for ZBTB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBTB4_HUMAN, Q9P1Z0
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZBTB4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB4:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Zbtb4 (no phenotypes)

    ZBTB4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zbtb4tm1(KOMP)Vlcg for ZBTB4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBTB4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZBTB4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBTB4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZBTB4 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZBTB4
    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB4 (see all 72):
    hsa-miR-631 hsa-miR-199a-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-519a hsa-miR-342-3p hsa-miR-93 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: ZBTB4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZBTB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZBTB4
    Sirion Biotech Customized adenovirus for overexpression of ZBTB4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZBTB4 (see all 13)
    OriGene ORF clones in mouse, rat for ZBTB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZBTB4 (NM_005341)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB4
    Sirion Biotech Customized lentivirus for stable overexpression of ZBTB4 
                         Customized lentivirus expression plasmids for stable overexpression of ZBTB4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ZBTB4
    Search LifeMap BioReagents cell lines for ZBTB4
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4


    Pathways & Interactions
    for ZBTB4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZBTB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ZBTB4 (Q9P1Z03 ENSP000003078584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    PIAS2O759283, ENSP000003816484I2D: score=1 STRING: ENSP00000381648
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    TP63ENSP000002647314STRING: ENSP00000264731
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZBTB4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZBTB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB4

    Search CenterWatch for drugs/clinical trials and news about ZBTB4

    Transcripts
    for ZBTB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZBTB4 gene (2 alternative transcripts): 
    NM_001128833.1  NM_020899.3  

    Unigene Cluster for ZBTB4:

    Zinc finger and BTB domain containing 4
    Hs.35096  [show with all ESTs]
    Unigene Representative Sequence: NM_020899
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380599(uc002ghc.4) ENST00000311403(uc002ghd.4)
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZBTB4
    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB4 (see all 72):
    hsa-miR-631 hsa-miR-199a-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-519a hsa-miR-342-3p hsa-miR-93 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: ZBTB4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZBTB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB4
    Clone
    Products:             		 OriGene clones in human, mouse for ZBTB4 (see all 13)
    OriGene ORF clones in mouse, rat for ZBTB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZBTB4 (NM_005341)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB4
    Sirion Biotech Customized lentivirus for stable overexpression of ZBTB4 
                         Customized lentivirus expression plasmids for stable overexpression of ZBTB4 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB4

    Additional mRNA sequence: 

    AB040971.2 AK027143.1 AK122826.1 AK122971.1 AY302699.1 BC015902.1 BC033259.1 BC043352.2 
    BC131774.1 

    10 DOTS entries:

    DT.100819620  DT.456393  DT.99957914  DT.91882042  DT.120976070  DT.304966  DT.95195736  DT.95285201 
    DT.95305021  DT.75156238 

    24/273 AceView cDNA sequences (see all 273):

    AA338527 CD691070 BX491712 AW468104 AA886994 BU161722 BC033259 AI198133 
    BE218908 AK122971 AA552903 AI669498 CA396494 T34845 AY302699 F28370 
    AI352607 BM697291 AI185028 AA255479 AK122826 BE017969 BC015902 AI203137 

    GeneLoc Exon Structure


    Expression
    for ZBTB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB4 expression in normal human tissues (normalized intensities)      ZBTB4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCTGGGA
    ZBTB4 Expression
    About this image


    ZBTB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow

    See ZBTB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB4

    SOURCE GeneReport for Unigene cluster: Hs.35096
        SABiosciences Custom PCR Arrays for ZBTB4
    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4

    Orthologs
    for ZBTB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB4 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zbtb41 , 5 zinc finger and BTB domain containing 41, 5 85.83(n)1
    88.48(a)1    		   11 (42.87 cM)5
    755801  NM_029348.21  NP_083624.21 
     697659125 
    lizard
    (Anolis carolinensis)    		 Reptilia ZBTB46
    		 Uncharacterized protein
    		 36(a)
    		 1 ↔ 1
    		 GL343660.1(198450-202067)
    zebrafish
    (Danio rerio)    		 Actinopterygii zbtb46
    		 zinc finger and BTB domain containing 4
    		 17(a)
    		 1 ↔ 1
    		 12(23884382-23896562)


    ENSEMBL Gene Tree for ZBTB4 (if available)
    TreeFam Gene Tree for ZBTB4 (if available)

    Paralogs
    for ZBTB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB4 gene
    ZBTB382  ZBTB332  
    18/27 SIMAP similar genes for ZBTB4 using alignment to 2 protein entries:     ZBTB4_HUMAN (see all proteins) (see all similar genes):
    KLHL36    ZBTB21    ZBTB3    ZNF295    HIC1    KLHL2
    ZBTB38    ZBTB17    ZBTB7C    KLHL32    ZBTB16    ZBTB20
    ZBTB25    KLHL18    MYNN    ZBTB49    NACC1    ZBTB45

    ZBTB4 for paralogs           About GeneDecksing



    Genomic Variants
    for ZBTB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/462 SNPs in ZBTB4 are shown (see all 462)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1922276641,2
    		--7255720(+) CCCTCC/TGTAAC 1 -- int10--------
    rs177328781,2
    		C,F,H--7255804(+) TCTTAT/CGGCCA 1 -- int121Minor allele frequency- C:0.15NA NS EA WA 2366
    rs1857619131,2
    		--7255948(+) GATGTG/TGGGCC 1 -- int10--------
    rs1136154331,2
    		C,F--7255959(+) AAAGTC/TAGCTT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1478797021,2
    		C--7256085(+) CTTTCC/TCCCAG 1 -- int10--------
    rs1414938771,2
    		--7256113(+) ATAATC/TGCACC 1 -- int10--------
    rs753451101,2
    		C,F--7256311(+) CTCTGC/TCACCA 1 -- ut311Minor allele frequency- T:0.06WA 118
    rs1891828681,2
    		--7256458(+) ATATTG/TTAATC 1 -- ut310--------
    rs92171,2
    		C,F,O,A,H--7256533(-) CTTAAA/GTATGA 1 -- ut3133Minor allele frequency- G:0.33MN EA NA NS WA CSA 3176
    rs124535721,2
    		C,F,H--7256553(+) ATGTCT/AACAAT 1 -- ut31 ese35Minor allele frequency- A:0.01NS EA NA 414

    HapMap Linkage Disequilibrium report for ZBTB4 (7362685 - 7387582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZBTB4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    dgv3054n71CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv523672CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB4
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB4

    Disorders / Diseases
    for ZBTB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 612308    OMIM disorders: --

    2 diseases for ZBTB4:    About MalaCards
    breast cancer    


    ZBTB4 for disorders           About GeneDecksing


    Export disorders for ZBTB4 gene to outside databases

    Publications
    for ZBTB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB4 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ZBTB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human protein kinase HIPK2 phosphorylates and dow nregulates the methyl-binding transcription factor ZBTB4. (PubMed id 19448668)1, 2 Yamada D....Defossez P.A. (2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    5. A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PubMed id 16354688)1, 9 Filion G.J....Defossez P.A. (2006)
    6. Identification of oncogenic microRNA-17-92/ZBTB4/speci ficity protein axis in breast cancer. (PubMed id 21765466)1 Kim K....Safe S. (2012)
    7. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    8. Sequence-specific recognition of methylated DNA by hu man zinc-finger proteins. (PubMed id 20403812)1 Sasai N....Defossez P.A. (2010)
    9. Identification of DeltaNp63alpha protein interactions by mass spectrometry. (PubMed id 20085233)1 Amoresano A....CalabrA^ V. (2010)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    External Searches for ZBTB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZBTB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57659 HGNC: 23847 AceView: ZBTB4 Ensembl:ENSG00000174282 euGenes: HUgn57659
    ECgene: ZBTB4 H-InvDB: ZBTB4

    Other Databases showing ZBTB4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1538

    Specialized Databases showing ZBTB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZBTB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZBTB4 gene:
    Search GeneIP for patents involving ZBTB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZBTB4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZBTB4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZBTB4  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZBTB4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZBTB4   OriGene Custom Protein Services for ZBTB4  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBTB4
     QIAGEN SeqTarget long-range PCR primers for resequencing ZBTB4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB4
     GenScript Custom Purified and Recombinant Proteins Services for ZBTB4 GenScript cDNA clones with any tag delivered in your preferred vector for ZBTB4
     GenScript Custom Assay Services for ZBTB4 GenScript Custom Superior Antibodies Services for ZBTB4
     GenScript Custom overexpressing Cell Line Services for ZBTB4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZBTB4 promoter
     Search Chromatin IP Primers for ZBTB4
     RT2 qPCR Primer Assay in human, mouse, rat ZBTB4
     GNC Network for ZBTB4
     SABiosciences Custom PCR Arrays for ZBTB4
     Search Tocris compounds for ZBTB4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZBTB4 antibodies
     ZBTB4 proteins
     Antibodies for ZBTB4
     See all of Abcam's Antibodies, Kits and Proteins for ZBTB4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZBTB4
     Antibodies for ZBTB4
     ELISAs for ZBTB4
     CLIAs for ZBTB4
     Search LifeMap BioReagents cell lines for ZBTB4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4
     SwitchGear 3'UTR luciferase reporter plasmids for ZBTB4
     SwitchGear Promoter luciferase reporter plasmids for ZBTB4
     ThermoFisher Antibodies for ZBTB4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBTB4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZBTB4
    Customized:
     lentivirus for stable overexpression of ZBTB4
     lentivirus expression plasmids for stable overexpression of ZBTB4
     adenovirus for overexpression of ZBTB4
     LSBio Antibodies in human, mouse, rat for ZBTB4
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ZBTB4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4