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ZBTB4 Gene

protein-coding   GIFtS: 50
GCID: GC17M007362

Zinc Finger And BTB Domain Containing 4
  See related disease
at
MalaCards
 

Aliases
for ZBTB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 41 2
KAISO-L12 3
KAISO-Like Zinc Finger Protein 12 3
KIAA15383 5
ZNF9032
Zinc Finger And BTB Domain-Containing Protein 42

External Ids:    HGNC: 238471   Entrez Gene: 576592   Ensembl: ENSG000001742827   OMIM: 6123085   UniProtKB: Q9P1Z03   

Export aliases for ZBTB4 gene to outside databases

Previous GC identifers: GC17M007563 GC17M007303


Summaries
for ZBTB4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZBTB4 Gene:
ZBTB4 (zinc finger and BTB domain containing 4) is a protein-coding gene. Diseases associated with ZBTB4 include breast cancer. An important paralog of this gene is ZBTB21.

UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0
Function: May be involved in transcriptional regulation




Genomic Views
for ZBTB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB4 gene promoter:
         GR   TBP   HOXA5   HNF-4alpha2   GR-alpha   Ik-3   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZBTB4 promoter sequence
   Search Chromatin IP Primers for ZBTB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

ZBTB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007362:  view genomic region     (about GC identifiers)

Start:
 7,362,685 bp from pter      End:
 7,387,582 bp from pter
Size:
 24,898 bases      Orientation:
 minus strand

Proteins
for ZBTB4 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 4  
Size: 1013 amino acids; 105114 Da
Subunit: Interacts with HIPK2
Sequence caution: Sequence=BAA96062.2; Type=Erroneous initiation;
Secondary accessions: B3KVL6 Q7Z697 Q86XJ4 Q8N4V8

Explore the universe of human proteins at neXtProt for ZBTB4: NX_Q9P1Z0

Explore proteomics data for ZBTB4 at MOPED

Post-translational modifications: 

  • Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response
    to DNA damage1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See ZBTB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001122305.1  NP_065950.2  

    ENSEMBL proteins: 
     ENSP00000369973   ENSP00000307858  

    ZBTB4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZBTB4

    ZBTB4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ZBTB4
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    ZBTB4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ZBTB4
    Cloud-Clone Corp. CLIAs for ZBTB4

    Domains /
    Families
    for ZBTB4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9P1Z0

    ProtoNet protein and cluster: Q9P1Z0

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 C2H2-type zinc fingers


    ZBTB4 for domains           About GeneDecksing


    Function
    for ZBTB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBTB4_HUMAN, Q9P1Z0
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding IPI16354688
    GO:0008327methyl-CpG binding IDA16354688
    GO:0010428methyl-CpNpG binding IDA--
    GO:0019901protein kinase binding IPI19448668
         
    ZBTB4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB4:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Zbtb4 (no phenotypes)

    ZBTB4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zbtb4tm1(KOMP)Vlcg for ZBTB4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZBTB4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBTB4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZBTB4

    miRNA
    Products:            		miRTarBase miRNAs that target ZBTB4:
    hsa-mir-30d-5p (MIRT047828), hsa-mir-19b-3p (MIRT031203), hsa-mir-652-3p (MIRT039514), hsa-mir-122-5p (MIRT023262), hsa-mir-454-3p (MIRT039221), hsa-mir-130b-3p (MIRT020226), hsa-mir-331-3p (MIRT043490), hsa-mir-1226-3p (MIRT036449), hsa-mir-99a-5p (MIRT048706), hsa-mir-181b-5p (MIRT047283), hsa-mir-615-3p (MIRT039695), hsa-mir-186-5p (MIRT044958)

    Block miRNA regulation of human, mouse, rat ZBTB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBTB4 (see all 72):
    hsa-miR-631 hsa-miR-199a-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-519a hsa-miR-342-3p hsa-miR-93 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: ZBTB4 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for ZBTB4
    Predesigned siRNA for gene silencing in human, mouse, rat ZBTB4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZBTB4

    Clone
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    OriGene ORF clones in mouse, rat for ZBTB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZBTB4 (NM_005341)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ZBTB4 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4


    Localization
    for ZBTB4 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZBTB4_HUMAN, Q9P1Z0: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16354688

    ZBTB4 for ontologies           About GeneDecksing


    Pathways & Interactions
    for ZBTB4 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB4
    Interactions:

        GeneGlobe Interaction Network for ZBTB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ZBTB4 (Q9P1Z03 ENSP000003078584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    PIAS2O759283, ENSP000003816484I2D: score=1 STRING: ENSP00000381648
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    TP63ENSP000002647314STRING: ENSP00000264731
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006974cellular response to DNA damage stimulus IDA19448668
    GO:0045892negative regulation of transcription, DNA-templated IDA16354688

    ZBTB4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZBTB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB4



    Transcripts
    for ZBTB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZBTB4 gene (2 alternative transcripts): 
    NM_001128833.1  NM_020899.3  

    Unigene Cluster for ZBTB4:

    Zinc finger and BTB domain containing 4
    Hs.35096  [show with all ESTs]
    Unigene Representative Sequence: NM_020899
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380599(uc002ghc.4) ENST00000311403(uc002ghd.4)
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat ZBTB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBTB4 (see all 72):
    hsa-miR-631 hsa-miR-199a-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-519a hsa-miR-342-3p hsa-miR-93 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: ZBTB4 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for ZBTB4
    Predesigned siRNA for gene silencing in human, mouse, rat ZBTB4
    Clone
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    OriGene ORF clones in mouse, rat for ZBTB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZBTB4 (NM_005341)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB4
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZBTB4
      QuantiTect SYBR Green Assays in human, mouse, rat ZBTB4
      QuantiFast Probe-based Assays in human, mouse, rat ZBTB4

    Additional mRNA sequence: 

    AB040971.2 AK027143.1 AK122826.1 AK122971.1 AY302699.1 BC015902.1 BC033259.1 BC043352.2 
    BC131774.1 

    10 DOTS entries:

    DT.100819620  DT.456393  DT.99957914  DT.91882042  DT.120976070  DT.304966  DT.95195736  DT.95285201 
    DT.95305021  DT.75156238 

    Selected AceView cDNA sequences (see all 273):

    AK122826 AI669498 BU161722 BU620047 AA552903 CA396494 BE218908 BM987036 
    AY302699 BE327655 AA338527 AI144539 BM664727 AB040971 BQ880799 CD691070 
    BM703239 AI191330 BM668322 AW468104 BC033259 BM713954 AA617772 BM692980 

    GeneLoc Exon Structure


    Expression
    for ZBTB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBTB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCTGGGA
    ZBTB4 Expression
    About this image


    ZBTB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    ZBTB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ZBTB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.35096
        Custom PCR Arrays for ZBTB4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4

    Orthologs
    for ZBTB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB4 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zbtb41 , 5 zinc finger and BTB domain containing 41, 5 84.98(n)1
    86.95(a)1    		   11 (42.87 cM)5
    755801  NM_029348.21  NP_083624.21 
     697659125 
    lizard
    (Anolis carolinensis)    		 Reptilia ZBTB46
    		 zinc finger and BTB domain containing 4
    		 48(a)
    		 1 ↔ 1
    		 GL343660.1(198450-202067)
    zebrafish
    (Danio rerio)    		 Actinopterygii zbtb46
    		 zinc finger and BTB domain containing 4
    		 22(a)
    		 1 ↔ 1
    		 12(23884369-23896562) ENSDARG00000061827


    ENSEMBL Gene Tree for ZBTB4 (if available)
    TreeFam Gene Tree for ZBTB4 (if available)

    Paralogs
    for ZBTB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBTB4 gene
    ZBTB212  ZBTB382  ZBTB332  ZBTB142  ZBTB7C2  ZBTB7A2  ZBTB7B2  
    Selected SIMAP similar genes for ZBTB4 using alignment to 2 protein entries:     ZBTB4_HUMAN (see all proteins) (see all similar genes):
    KLHL36    ZBTB21    ZBTB3    ZNF295    HIC1    KLHL2
    ZBTB38    ZBTB17    ZBTB7C    KLHL32    ZBTB16    ZBTB20
    ZBTB25    KLHL18    MYNN    ZBTB49    NACC1    ZBTB45

    ZBTB4 for paralogs           About GeneDecksing



    Genomic Variants
    for ZBTB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ZBTB4 (see all 462)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1922276641,2
    		--7255720(+) CCCTCC/TGTAAC 1 -- int10--------
    rs177328781,2
    		C,F,H--7255804(+) TCTTAT/CGGCCA 1 -- int121Minor allele frequency- C:0.15NA NS EA WA 2366
    rs1857619131,2
    		--7255948(+) GATGTG/TGGGCC 1 -- int10--------
    rs1136154331,2
    		C,F--7255959(+) AAAGTC/TAGCTT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1478797021,2
    		C--7256085(+) CTTTCC/TCCCAG 1 -- int10--------
    rs1414938771,2
    		--7256113(+) ATAATC/TGCACC 1 -- int10--------
    rs753451101,2
    		C,F--7256311(+) CTCTGC/TCACCA 1 -- ut311Minor allele frequency- T:0.06WA 118
    rs1891828681,2
    		--7256458(+) ATATTG/TTAATC 1 -- ut310--------
    rs92171,2
    		C,F,O,A,H--7256533(-) CTTAAA/GTATGA 1 -- ut3133Minor allele frequency- G:0.33MN EA NA NS WA CSA 3176
    rs124535721,2
    		C,F,H--7256553(+) ATGTCT/AACAAT 1 -- ut31 ese35Minor allele frequency- A:0.01NS EA NA 414

    HapMap Linkage Disequilibrium report for ZBTB4 (7362685 - 7387582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZBTB4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    dgv3054n71CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv523672CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB4
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB4

    Disorders / Diseases
    for ZBTB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612308    OMIM disorders: --

    1 disease for ZBTB4:    
    About MalaCards
    breast cancer


    ZBTB4 for disorders           About GeneDecksing


    Export disorders for ZBTB4 gene to outside databases

    Publications
    for ZBTB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBTB4 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ZBTB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. (PubMed id 19448668)1, 2 Yamada D.... Defossez P.A. (Oncogene 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PubMed id 16354688)1, 9 Filion G.J....Defossez P.A. (Mol. Cell. Biol. 2006)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. (PubMed id 21765466)1 Kim K....Safe S. (Oncogene 2012)
    8. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. Identification of DeltaNp63alpha protein interactions by mass spectrometry. (PubMed id 20085233)1 Amoresano A....CalabrA^ V. (J. Proteome Res. 2010)

    External Searches for ZBTB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ZBTB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57659 HGNC: 23847 AceView: ZBTB4 Ensembl:ENSG00000174282 euGenes: HUgn57659
    ECgene: ZBTB4 H-InvDB: ZBTB4

    Other Databases showing ZBTB4 gene

    (According to HUGE)
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    HUGE: KIAA1538

    Specialized Databases showing ZBTB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZBTB4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZBTB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    TryGeneCards Plus    		Patent Information for ZBTB4 gene:
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