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Aliases for ZBTB4 Gene

Aliases for ZBTB4 Gene

  • Zinc Finger And BTB Domain Containing 4 2 3
  • KAISO-Like Zinc Finger Protein 1 3 4
  • KAISO-L1 3 4
  • KIAA1538 4 6
  • Zinc Finger And BTB Domain-Containing Protein 4 3
  • ZNF903 3

External Ids for ZBTB4 Gene

Summaries for ZBTB4 Gene

GeneCards Summary for ZBTB4 Gene

ZBTB4 (Zinc Finger And BTB Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is ZBTB7B.

UniProtKB/Swiss-Prot for ZBTB4 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB4 Gene

Genomics for ZBTB4 Gene

Genomic Location for ZBTB4 Gene

7,459,366 bp from pter
7,484,263 bp from pter
24,898 bases
Minus strand

Genomic View for ZBTB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB4 Gene

Regulatory Elements for ZBTB4 Gene

Proteins for ZBTB4 Gene

  • Protein details for ZBTB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B3KVL6
    • Q7Z697
    • Q86XJ4
    • Q8N4V8

    Protein attributes for ZBTB4 Gene

    1013 amino acids
    Molecular mass:
    105114 Da
    Quaternary structure:
    • Interacts with HIPK2.
    • Sequence=BAA96062.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZBTB4 Gene

Proteomics data for ZBTB4 Gene at MOPED

Post-translational modifications for ZBTB4 Gene

  • Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB4 Gene

Domains for ZBTB4 Gene

Gene Families for ZBTB4 Gene

  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

Protein Domains for ZBTB4 Gene


  • Contains 1 BTB (POZ) domain.:
    • Q9P1Z0
  • Contains 6 C2H2-type zinc fingers.:
    • Q9P1Z0
genes like me logo Genes that share domains with ZBTB4: view

Function for ZBTB4 Gene

Molecular function for ZBTB4 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZBTB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 16354688
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 16354688
GO:0005515 protein binding IPI 16354688
GO:0008327 methyl-CpG binding IDA 16354688
GO:0010428 methyl-CpNpG binding IDA 20403812
genes like me logo Genes that share ontologies with ZBTB4: view

Phenotypes for ZBTB4 Gene

GenomeRNAi human phenotypes for ZBTB4:
genes like me logo Genes that share phenotypes with ZBTB4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB4 Gene

Localization for ZBTB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB4 Gene

Subcellular locations from

Jensen Localization Image for ZBTB4 Gene COMPARTMENTS Subcellular localization image for ZBTB4 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for ZBTB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16354688
genes like me logo Genes that share ontologies with ZBTB4: view

Pathways for ZBTB4 Gene

SuperPathways for ZBTB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16354688
GO:0006351 transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 19448668
GO:0045892 negative regulation of transcription, DNA-templated IDA 16354688
genes like me logo Genes that share ontologies with ZBTB4: view

No data available for Pathways by source for ZBTB4 Gene

Transcripts for ZBTB4 Gene

Unigene Clusters for ZBTB4 Gene

Zinc finger and BTB domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB4 Gene

No ASD Table

Relevant External Links for ZBTB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB4 Gene

mRNA expression in normal human tissues for ZBTB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZBTB4 Gene

SOURCE GeneReport for Unigene cluster for ZBTB4 Gene Hs.35096

genes like me logo Genes that share expressions with ZBTB4: view

Orthologs for ZBTB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB4 36
  • 98.88 (n)
  • 98.81 (a)
ZBTB4 37
  • 100 (a)
(Bos Taurus)
Mammalia ZBTB4 36
  • 86.87 (n)
  • 89.15 (a)
ZBTB4 37
  • 90 (a)
(Canis familiaris)
Mammalia ZBTB4 36
  • 85.94 (n)
  • 89.8 (a)
ZBTB4 37
  • 90 (a)
(Mus musculus)
Mammalia Zbtb4 36
  • 84.98 (n)
  • 86.95 (a)
Zbtb4 16
Zbtb4 37
  • 88 (a)
(Monodelphis domestica)
Mammalia ZBTB4 37
  • 78 (a)
(Rattus norvegicus)
Mammalia Zbtb4 36
  • 84.61 (n)
  • 86.44 (a)
(Anolis carolinensis)
Reptilia ZBTB4 37
  • 48 (a)
(Danio rerio)
Actinopterygii zbtb4 37
  • 22 (a)
Species with no ortholog for ZBTB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB4 Gene

Gene Tree for ZBTB4 (if available)
Gene Tree for ZBTB4 (if available)

Paralogs for ZBTB4 Gene

Paralogs for ZBTB4 Gene

genes like me logo Genes that share paralogs with ZBTB4: view

Variants for ZBTB4 Gene

Sequence variations from dbSNP and Humsavar for ZBTB4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9217 -- 7,459,769(-) CTTAA(A/G)TATGA utr-variant-3-prime
rs10729 -- 7,460,121(+) TTTTT(G/T)TGTGT utr-variant-3-prime
rs871990 - 7,463,332(+) GTGGC(C/G)ATGGC missense, reference
rs1047300 -- 7,459,524(-) TGGTT(C/T)TGTGC utr-variant-3-prime
rs2241234 -- 7,478,435(-) TTTGC(A/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB4 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv523672 CNV Loss 19592680
dgv3054n71 CNV Loss 21882294

Relevant External Links for ZBTB4 Gene

HapMap Linkage Disequilibrium report

Disorders for ZBTB4 Gene

No disorders were found for ZBTB4 Gene.

No data available for UniProtKB/Swiss-Prot for ZBTB4 Gene

Publications for ZBTB4 Gene

  1. A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PMID: 16354688) Filion G.J. … Defossez P.A. (Mol. Cell. Biol. 2006) 2 3 23
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. (PMID: 19448668) Yamada D. … Defossez P.A. (Oncogene 2009) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. (PMID: 25499219) Yang W.S. … Kim K. (Neoplasia 2014) 2 3

Products for ZBTB4 Gene

Sources for ZBTB4 Gene

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