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ZBTB4 Gene(Protein Coding)

Zinc Finger And BTB Domain Containing 4

GCID:
GC17M007459
GIFtS:
41
Genes Participants
UDN Logo

Aliases for ZBTB4 Gene

Aliases for ZBTB4 Gene

  • Zinc Finger And BTB Domain Containing 4 2 3 5
  • KAISO-Like Zinc Finger Protein 1 3 4
  • KAISO-L1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 4 3
  • KIAA1538 4
  • ZNF903 3

External Ids for ZBTB4 Gene

Previous GeneCards Identifiers for ZBTB4 Gene

  • GC17M007563
  • GC17M007303
  • GC17M007362

Summaries for ZBTB4 Gene

GeneCards Summary for ZBTB4 Gene

ZBTB4 (Zinc Finger And BTB Domain Containing 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase binding. An important paralog of this gene is ZBTB38.

UniProtKB/Swiss-Prot for ZBTB4 Gene

  • Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5-CGCG-3 but can also bind to the non-methylated consensus sequence 5-CTGCNA-3 also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).

Additional gene information for ZBTB4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB4 Gene

Genomics for ZBTB4 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ZBTB4 Gene

Promoters and enhancers for ZBTB4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17I007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565.7 +3.7 3674 12.5 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC POLR2A ZBTB4 SLC35G6 DVL2 PFAS SNORD10 CTC1 WRAP53 SNORA48 CNTROB
GH17I007233 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 29.3 +245.6 245604 11.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 DVL2 GABARAP PHF23 CNTROB SNORD10 NEURL4 SNORA48 WRAP53 POLR2A KCTD11
GH17I007833 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.4 -355.5 -355466 12.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 KDM6B DVL2 PFAS CTC1 WRAP53 CNTROB POLR2A SNORD10 SNORA48 PER1
GH17I008117 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.2 -637.0 -637004 7.7 CLOCK FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZFP41 SSRP1 HES7 ALOXE3 GC17M008514 TRQ-CTG1-5 TRR-TCT2-1 TRL-TAG1-1 NEURL4 SENP3 NLGN2 DVL2
GH17I008245 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.1 -763.7 -763668 5.5 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 PFAS CTC1 NEURL4 SENP3 CYB5D1 RANGRF CNTROB WRAP53 ZBTB4 NLGN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB4 gene promoter:

Genomic Locations for ZBTB4 Gene

Genomic Locations for ZBTB4 Gene
chr17:7,459,366-7,484,263
(GRCh38/hg38)
Size:
24,898 bases
Orientation:
Minus strand
chr17:7,362,685-7,387,582
(GRCh37/hg19)

Genomic View for ZBTB4 Gene

Genes around ZBTB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZBTB4 Gene

Proteins for ZBTB4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZBTB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1Z0-ZBTB4_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 4
    Protein Accession:
    Q9P1Z0
    Secondary Accessions:
    • B3KVL6
    • Q7Z697
    • Q86XJ4
    • Q8N4V8

    Protein attributes for ZBTB4 Gene

    Size:
    1013 amino acids
    Molecular mass:
    105114 Da
    Quaternary structure:
    • Interacts with HIPK2. Interacts with CBFA2T3. Interacts with ZBTB38.
    SequenceCaution:
    • Sequence=BAA96062.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZBTB4 Gene

Protein Expression for ZBTB4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZBTB4 Gene

  • Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage.

Other Protein References for ZBTB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB4 Gene

Domains & Families for ZBTB4 Gene

Gene Families for ZBTB4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB4: view

No data available for UniProtKB/Swiss-Prot for ZBTB4 Gene

Function for ZBTB4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZBTB4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5-CGCG-3 but can also bind to the non-methylated consensus sequence 5-CTGCNA-3 also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).

Phenotypes From GWAS Catalog for ZBTB4 Gene

Gene Ontology (GO) - Molecular Function for ZBTB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 16354688
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 16354688
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16354688
genes like me logo Genes that share ontologies with ZBTB4: view
genes like me logo Genes that share phenotypes with ZBTB4: view

Animal Models for ZBTB4 Gene

MGI Knock Outs for ZBTB4:

Animal Model Products

miRNA for ZBTB4 Gene

miRTarBase miRNAs that target ZBTB4

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB4 Gene

Localization for ZBTB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB4 Gene

Nucleus. Chromosome. Note=Localizes to chromocenters. {ECO:0000269 PubMed:16354688}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB4 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 16354688
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005829 cytosol IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with ZBTB4: view

Pathways & Interactions for ZBTB4 Gene

SuperPathways for ZBTB4 Gene

PathCards logo More details on SuperPathways for ZBTB4
No Data Available

Gene Ontology (GO) - Biological Process for ZBTB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 16354688
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 19448668
GO:0045892 negative regulation of transcription, DNA-templated IDA 16354688
genes like me logo Genes that share ontologies with ZBTB4: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB4 Gene

Drugs & Compounds for ZBTB4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZBTB4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZBTB4 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(273) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB4 Gene

Zinc finger and BTB domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB4 Gene

No ASD Table

Relevant External Links for ZBTB4 Gene

GeneLoc Exon Structure for
ZBTB4
ECgene alternative splicing isoforms for
ZBTB4

Expression for ZBTB4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB4 Gene

mRNA expression in normal human tissues for ZBTB4 Gene
mRNA expression by GTEx for ZBTB4 GenemRNA expression by BioGPS for ZBTB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB4 Gene

This gene is overexpressed in Adipocyte (18.9), Heart (11.8), Pancreatic juice (11.7), CD8 Tcells (10.0), and Retina (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB4 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZBTB4 Gene:

ZBTB4

SOURCE GeneReport for Unigene cluster for ZBTB4 Gene:

Hs.35096

Evidence on tissue expression from TISSUES for ZBTB4 Gene

  • Nervous system(4.8)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with ZBTB4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB4 Gene

Orthologs for ZBTB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZBTB4 33 34
  • 98.88 (n)
cow
(Bos Taurus)
 Mammalia ZBTB4 33 34
  • 86.87 (n)
dog
(Canis familiaris)
 Mammalia ZBTB4 33 34
  • 85.94 (n)
mouse
(Mus musculus)
 Mammalia Zbtb4 33 16 34
  • 84.98 (n)
rat
(Rattus norvegicus)
 Mammalia Zbtb4 33
  • 84.61 (n)
oppossum
(Monodelphis domestica)
 Mammalia ZBTB4 34
  • 78 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ZBTB4 34
  • 48 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii zbtb4 34
  • 22 (a)
 OneToOne
Species where no ortholog for ZBTB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB4 Gene

ENSEMBL:
Gene Tree for ZBTB4 (if available)
TreeFam:
Gene Tree for ZBTB4 (if available)

Paralogs for ZBTB4 Gene

Paralogs for ZBTB4 Gene

(28) SIMAP similar genes for ZBTB4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZBTB4: view

Variants for ZBTB4 Gene

Sequence variations from dbSNP and Humsavar for ZBTB4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000037248 -- 7,475,121(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000232440 -- 7,477,714(-) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000373927 -- 7,474,407(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000442425 -- 7,479,604(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000460840 -- 7,484,368(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB4 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv1143849 CNV deletion 24896259
nsv457659 CNV loss 19166990
nsv523672 CNV loss 19592680
nsv574322 CNV loss 21841781

Variation tolerance for ZBTB4 Gene

Residual Variation Intolerance Score: 9.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB4 Gene

Disorders for ZBTB4 Gene

Additional Disease Information for ZBTB4

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZBTB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB4 Gene

Publications for ZBTB4 Gene

  1. A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PMID: 16354688) Filion GJ … Defossez PA (Molecular and cellular biology 2006) 2 3 4 22 58
  2. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. (PMID: 25499219) Yang WS … Kim K (Neoplasia (New York, N.Y.) 2014) 2 3 58
  3. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. (PMID: 23251453) Barrett CW … Williams CS (PloS one 2012) 3 4 58
  4. The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. (PMID: 19448668) Yamada D … Defossez PA (Oncogene 2009) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ZBTB4 Gene

Sources for ZBTB4 Gene

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