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Aliases for ZBTB4 Gene

Aliases for ZBTB4 Gene

  • Zinc Finger And BTB Domain Containing 4 2 3 5
  • KAISO-Like Zinc Finger Protein 1 3 4
  • KAISO-L1 3 4
  • KIAA1538 4
  • ZNF903 3

External Ids for ZBTB4 Gene

Previous GeneCards Identifiers for ZBTB4 Gene

  • GC17M007563
  • GC17M007303
  • GC17M007362

Summaries for ZBTB4 Gene

GeneCards Summary for ZBTB4 Gene

ZBTB4 (Zinc Finger And BTB Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and protein kinase binding. An important paralog of this gene is ZBTB21.

UniProtKB/Swiss-Prot for ZBTB4 Gene

  • Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5-CGCG-3 but can also bind to the non-methylated consensus sequence 5-CTGCNA-3 also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB4 Gene

Genomics for ZBTB4 Gene

Regulatory Elements for ZBTB4 Gene

Promoters for ZBTB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB4 Gene

Chromosome:
17
Start:
7,459,366 bp from pter
End:
7,484,263 bp from pter
Size:
24,898 bases
Orientation:
Minus strand

Genomic View for ZBTB4 Gene

Genes around ZBTB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB4 Gene

Proteins for ZBTB4 Gene

  • Protein details for ZBTB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1Z0-ZBTB4_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 4
    Protein Accession:
    Q9P1Z0
    Secondary Accessions:
    • B3KVL6
    • Q7Z697
    • Q86XJ4
    • Q8N4V8

    Protein attributes for ZBTB4 Gene

    Size:
    1013 amino acids
    Molecular mass:
    105114 Da
    Quaternary structure:
    • Interacts with HIPK2. Interacts with CBFA2T3. Interacts with ZBTB38.
    SequenceCaution:
    • Sequence=BAA96062.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZBTB4 Gene

Proteomics data for ZBTB4 Gene at MOPED

Post-translational modifications for ZBTB4 Gene

  • Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB4 Gene

Domains & Families for ZBTB4 Gene

Gene Families for ZBTB4 Gene

Protein Domains for ZBTB4 Gene

Suggested Antigen Peptide Sequences for ZBTB4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1Z0

UniProtKB/Swiss-Prot:

ZBTB4_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 6 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB4: view

Function for ZBTB4 Gene

Molecular function for ZBTB4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5-CGCG-3 but can also bind to the non-methylated consensus sequence 5-CTGCNA-3 also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688).

Gene Ontology (GO) - Molecular Function for ZBTB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 16354688
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 16354688
GO:0008327 methyl-CpG binding IDA 16354688
GO:0010428 methyl-CpNpG binding IDA 20403812
GO:0042803 protein homodimerization activity IDA 16354688
genes like me logo Genes that share ontologies with ZBTB4: view
genes like me logo Genes that share phenotypes with ZBTB4: view

Animal Models for ZBTB4 Gene

MGI Knock Outs for ZBTB4:

Animal Model Products

miRNA for ZBTB4 Gene

miRTarBase miRNAs that target ZBTB4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB4 Gene

Localization for ZBTB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB4 Gene

Nucleus. Chromosome. Note=Localizes to chromocenters. {ECO:0000269 PubMed:16354688}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB4 Gene COMPARTMENTS Subcellular localization image for ZBTB4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with ZBTB4: view

Pathways & Interactions for ZBTB4 Gene

SuperPathways for ZBTB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IDA 16354688
genes like me logo Genes that share ontologies with ZBTB4: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB4 Gene

Drugs & Compounds for ZBTB4 Gene

No Compound Related Data Available

Transcripts for ZBTB4 Gene

Unigene Clusters for ZBTB4 Gene

Zinc finger and BTB domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB4 Gene

No ASD Table

Relevant External Links for ZBTB4 Gene

GeneLoc Exon Structure for
ZBTB4
ECgene alternative splicing isoforms for
ZBTB4

Expression for ZBTB4 Gene

mRNA expression in normal human tissues for ZBTB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB4 Gene

This gene is overexpressed in Adipocyte (18.9), Heart (11.8), Pancreatic juice (11.7), CD8 Tcells (10.0), and Retina (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB4 Gene



SOURCE GeneReport for Unigene cluster for ZBTB4 Gene Hs.35096

genes like me logo Genes that share expression patterns with ZBTB4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZBTB4 Gene

Orthologs for ZBTB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBTB4 35
  • 86.87 (n)
  • 89.15 (a)
ZBTB4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB4 35
  • 85.94 (n)
  • 89.8 (a)
ZBTB4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb4 35
  • 84.98 (n)
  • 86.95 (a)
Zbtb4 16
Zbtb4 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBTB4 35
  • 98.88 (n)
  • 98.81 (a)
ZBTB4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb4 35
  • 84.61 (n)
  • 86.44 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBTB4 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB4 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zbtb4 36
  • 22 (a)
OneToOne
Species with no ortholog for ZBTB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB4 Gene

ENSEMBL:
Gene Tree for ZBTB4 (if available)
TreeFam:
Gene Tree for ZBTB4 (if available)

Paralogs for ZBTB4 Gene

Paralogs for ZBTB4 Gene

genes like me logo Genes that share paralogs with ZBTB4: view

Variants for ZBTB4 Gene

Sequence variations from dbSNP and Humsavar for ZBTB4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs871990 - 7,463,332(+) GTGGC(A/C/G)ATGGC reference, missense
rs35231078 - 7,463,366(-) CACAG(C/T)AGTCA reference, missense
rs34914463 - 7,463,300(-) CCGGA(A/G)TCCAC reference, missense
rs9217 -- 7,459,769(-) CTTAA(A/G)TATGA utr-variant-3-prime
rs10729 -- 7,460,121(+) TTTTT(G/T)TGTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZBTB4 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv523672 CNV Loss 19592680
dgv3054n71 CNV Loss 21882294

Variation tolerance for ZBTB4 Gene

Residual Variation Intolerance Score: 9.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB4 Gene

HapMap Linkage Disequilibrium report
ZBTB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB4 Gene

Disorders for ZBTB4 Gene

Relevant External Links for ZBTB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB4

No disorders were found for ZBTB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB4 Gene

Publications for ZBTB4 Gene

  1. A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PMID: 16354688) Filion G.J. … Defossez P.A. (Mol. Cell. Biol. 2006) 2 3 4 23 67
  2. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. (PMID: 25499219) Yang W.S. … Kim K. (Neoplasia 2014) 2 3
  3. Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. (PMID: 21765466) Kim K. … Safe S. (Oncogene 2012) 3
  4. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. (PMID: 23251453) Barrett C.W. … Williams C.S. (PLoS ONE 2012) 3
  5. Identification of DeltaNp63alpha protein interactions by mass spectrometry. (PMID: 20085233) Amoresano A. … CalabrA^ V. (J. Proteome Res. 2010) 3

Products for ZBTB4 Gene

Sources for ZBTB4 Gene

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