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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB4 Gene

protein-coding   GIFtS: 48
GCID: GC17M007362

zinc finger and BTB domain containing 4

  Search for ZBTB4
in our new
 Human Malady Compendium 
Biological research products
for ZBTB4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 41 2
KAISO-L11 2 3
KIAA15381 3 5
ZNF9031 2
KAISO-Like Zinc Finger Protein 12 3
Zinc Finger And BTB Domain-Containing Protein 42

External Ids:    HGNC: 238471   Entrez Gene: 576592   Ensembl: ENSG000001742827   OMIM: 6123085   UniProtKB: Q9P1Z03   

Export aliases for ZBTB4 gene to outside databases

Previous GC identifers: GC17M007563 GC17M007303


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB4 gene promoter:
         GR   TBP   HOXA5   HNF-4alpha2   GR-alpha   Ik-3   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZBTB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

ZBTB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007362:  view genomic region     (about GC identifiers)

Start:
7,362,685 bp from pter      End:
7,387,582 bp from pter
Size:
24,898 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 4  
Size: 1013 amino acids; 105114 Da
Subunit: Interacts with HIPK2
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA96062.2; Type=Erroneous initiation;
Secondary accessions: B3KVL6 Q7Z697 Q86XJ4 Q8N4V8

Explore the universe of human proteins at neXtProt for ZBTB4: NX_Q9P1Z0

Post-translational modifications:

  • Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to
  • DNA damage1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P1Z0

  • ZBTB4 Protein expression data from MOPED and PaxDb:    About this image 
    ZBTB4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001122305.1  NP_065950.2  

    ENSEMBL proteins: 
     ENSP00000369973   ENSP00000307858  

    Human Recombinant Protein Products for ZBTB4: 
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    Uscn Proteins for ZBTB4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZBTB4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZBTB4


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZBTB4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q9P1Z0

    ProtoNet protein and cluster: Q9P1Z0

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBTB4_HUMAN, Q9P1Z0
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBTB4_HUMAN, Q9P1Z0
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZBTB4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZBTB4 

    miRNA
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    In Situ Assay
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZBTB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ZBTB4 (Q9P1Z03 ENSP000003078584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    PIAS2O759283, ENSP000003816484I2D: score=1 STRING: ENSP00000381648
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    TP63ENSP000002647314STRING: ENSP00000264731
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZBTB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB4
    Search CenterWatch for drugs/clinical trials and news about ZBTB4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZBTB4 gene (2 alternative transcripts): 
    NM_001128833.1  NM_020899.3  

    Unigene Cluster for ZBTB4:

    Zinc finger and BTB domain containing 4
    Hs.35096  [show with all ESTs]
    Unigene Representative Sequence: NM_020899
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380599(uc002ghc.4) ENST00000311403(uc002ghd.4)

    miRNA
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    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB4 (see all 72):
    hsa-miR-631 hsa-miR-199a-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-519a hsa-miR-342-3p hsa-miR-93 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidZBTB4 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBTB4 (see all 4)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB4

    Additional cDNA sequence: 

    AB040971.2 AK027143.1 AK122826.1 AK122971.1 AY302699.1 BC015902.1 BC033259.1 BC043352.2 
    BC131774.1 

    10 DOTS entries:

    DT.100819620  DT.456393  DT.99957914  DT.91882042  DT.120976070  DT.304966  DT.95195736  DT.95285201 
    DT.95305021  DT.75156238 

    24/273 AceView cDNA sequences (see all 273):

    BM697291 CB306760 BX491712 AB040971 AI203137 AI198133 AK122826 CA395952 
    BM692980 BU161722 AI144539 BM703239 AY302699 W37794 BC033259 AI669498 
    BM668322 BM664727 BQ880799 AI185028 AA617772 BU620047 BM563262 BM987036 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCCCTGGGA
    ZBTB4 Expression
    About this image

    ZBTB4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumEndocardial Tube CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZBTB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB4

    SOURCE GeneReport for Unigene cluster: Hs.35096
        SABiosciences Custom PCR Arrays for ZBTB4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB4 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB46
    --
    44(a)
    1 ↔ 1
    GL343660.1(198450-202067)
    zebrafish
    (Danio rerio)
    Actinopterygii zbtb46
    zinc finger and BTB domain containing 4
    20(a)
    1 ↔ 1
    12(23884382-23896562)


    ENSEMBL Gene Tree for ZBTB4 (if available)
    TreeFam Gene Tree for ZBTB4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB4 gene
    ZBTB212  ZBTB382  ZBTB332  
    18/27 SIMAP similar genes for ZBTB4 using alignment to 2 protein entries:     ZBTB4_HUMAN (see all proteins) (see all similar genes):
    KLHL36    ZBTB21    ZBTB3    ZNF295    HIC1    KLHL2
    ZBTB10    ZBTB38    ZBTB17    ZBTB7C    KLHL32    ZBTB16
    ZBTB20    ZBTB25    KLHL18    MYNN    ZBTB49    NACC1

    ZBTB4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/387 NCBI SNPs in ZBTB4 are shown (see all 387    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs177328781,2
    C,F,H--7255804(+) TCTTAT/CGGCCA 1 -- int121Minor allele frequency- C:0.15NA NS EA WA 2366
    rs1136154331,2
    C--7255959(+) AAAGTC/TAGCTT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs753451101,2
    C,F--7256311(+) CTCTGC/TCACCA 1 -- ut311Minor allele frequency- T:0.06WA 118
    rs124535721,2
    C,F,H--7256553(+) ATGTCT/AACAAT 1 -- ut31 ese35Minor allele frequency- A:0.01NS EA NA 414
    rs340550231,2
    C,F--7256918(+) CCCCCC/GCTTAA 1 -- ut313Minor allele frequency- G:0.11NA EA 124
    rs1116903051,2
    --7258468(+) CCCCTC/GATGGA 1 -- ut310--------
    rs1126782321,2
    --7259326(+) GCCAGC/TGCTGC 2 T A mis11Minor allele frequency- T:0.50CSA 2
    rs353767271,2
    F--7259376(-) TGCTGA/G/TGCGGC 3 E G V mis11NA 38
    rs347390551,2
    C--7261126(+) TGAGG-/TTGCAG 1 -- int11Minor allele frequency- T:0.00NA 2
    rs348099081,2
    C,F--7261271(+) AGCAGG/AGNNNN 1 -- int16Minor allele frequency- A:0.09NA WA CSA 246

    HapMap Linkage Disequilibrium report for ZBTB4 (7362685 - 7387582 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZBTB4: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZBTB4 for disorders           About MalaCards

    ZBTB4 for disorders           About GeneDecksing

    OMIM gene information: 612308    OMIM disorders: --


    Export disorders for ZBTB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB4 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ZBTB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human protein kinase HIPK2 phosphorylates and dow nregulates the methyl-binding transcription factor ZBTB4. (PubMed id 19448668)1, 2 Yamada D....Defossez P.A. (2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    5. A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PubMed id 16354688)1, 9 Filion G.J....Defossez P.A. (2006)
    6. Identification of oncogenic microRNA-17-92/ZBTB4/speci ficity protein axis in breast cancer. (PubMed id 21765466)1 Kim K....Safe S. (2012)
    7. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    8. Sequence-specific recognition of methylated DNA by hu man zinc-finger proteins. (PubMed id 20403812)1 Sasai N....Defossez P.A. (2010)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57659 HGNC: 23847 AceView: ZBTB4 Ensembl:ENSG00000174282 euGenes: HUgn57659
    ECgene: ZBTB4 H-InvDB: ZBTB4

    (According to HUGE)
    About This Section
    HUGE: KIAA1538

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZBTB4 gene:
    Search GeneIP for patents involving ZBTB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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    von Willebrand factor
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