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Aliases for ZBTB39 Gene

Aliases for ZBTB39 Gene

  • Zinc Finger And BTB Domain Containing 39 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 39 3
  • KIAA0352 4
  • ZNF922 3

External Ids for ZBTB39 Gene

Previous GeneCards Identifiers for ZBTB39 Gene

  • GC12M055679
  • GC12M057392
  • GC12M054431

Summaries for ZBTB39 Gene

GeneCards Summary for ZBTB39 Gene

ZBTB39 (Zinc Finger And BTB Domain Containing 39) is a Protein Coding gene. An important paralog of this gene is ZBTB16.

UniProtKB/Swiss-Prot for ZBTB39 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB39 Gene

Genomics for ZBTB39 Gene

Regulatory Elements for ZBTB39 Gene

Enhancers for ZBTB39 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F056220 1.2 ENCODE 51.1 +783.6 783632 5.7 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NEMP1 ANKRD52 BAZ2A PHC1P1 ZBTB39 TMEM198B SMARCC2 RN7SL809P ENSG00000258317 STAT2
GH12F056266 1.1 ENCODE 42.7 +739.3 739320 2.0 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 NEMP1 ANKRD52 BAZ2A PHC1P1 ZBTB39 SMARCC2 RN7SL809P ENSG00000258317 CDK2 TMEM198B
GH12F057109 1.2 ENCODE 29.4 -104.7 -104741 3.8 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 MCM3 SP3 NEMP1 BAZ2A ANKRD52 CTDSP2 RN7SL809P ENSG00000224713 ENSG00000258317 ZC3H10 TSPAN31 RNU6-343P
GH12F056718 1.2 ENCODE 29.3 +284.0 283955 8.9 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 MCM3 NEMP1 BAZ2A ANKRD52 RN7SL809P ENSG00000224713 TMEM198B ZC3H10 RNU6-343P CDK2 SMARCC2
GH12F056187 1.2 ENCODE 21 +817.1 817057 3.5 HDGF ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 BAZ2A NEMP1 ZC3H10 RN7SL809P ENSG00000258317 CDK2 RNU6-343P ANKRD52 ZBTB39 PA2G4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB39 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000653712 313 1601 ZNF76 EGR1 ZNF680 ZBTB11 ZNF24 MYC ZBTB26 CTCF ZNF146 JUN

Genomic Location for ZBTB39 Gene

Chromosome:
12
Start:
56,998,833 bp from pter
End:
57,006,513 bp from pter
Size:
7,681 bases
Orientation:
Minus strand

Genomic View for ZBTB39 Gene

Genes around ZBTB39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB39 Gene

Proteins for ZBTB39 Gene

  • Protein details for ZBTB39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15060-ZBT39_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 39
    Protein Accession:
    O15060
    Secondary Accessions:
    • A7MD38
    • Q9UD98

    Protein attributes for ZBTB39 Gene

    Size:
    712 amino acids
    Molecular mass:
    79001 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20809.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZBTB39 Gene

Post-translational modifications for ZBTB39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB39 Gene

Domains & Families for ZBTB39 Gene

Gene Families for ZBTB39 Gene

Suggested Antigen Peptide Sequences for ZBTB39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15060

UniProtKB/Swiss-Prot:

ZBT39_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB39: view

Function for ZBTB39 Gene

Molecular function for ZBTB39 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB39: view

Phenotypes for ZBTB39 Gene

genes like me logo Genes that share phenotypes with ZBTB39: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB39 Gene

Localization for ZBTB39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB39 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB39 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB39: view

Pathways & Interactions for ZBTB39 Gene

SuperPathways for ZBTB39 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB39: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB39 Gene

Transcripts for ZBTB39 Gene

mRNA/cDNA for ZBTB39 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB39 Gene

Zinc finger and BTB domain containing 39:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB39 Gene

No ASD Table

Relevant External Links for ZBTB39 Gene

GeneLoc Exon Structure for
ZBTB39
ECgene alternative splicing isoforms for
ZBTB39

Expression for ZBTB39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB39 Gene

Protein differential expression in normal tissues from HIPED for ZBTB39 Gene

This gene is overexpressed in Breast (51.8), Plasma (10.8), and Adipocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB39 Gene



Protein tissue co-expression partners for ZBTB39 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB39 Gene:

ZBTB39

SOURCE GeneReport for Unigene cluster for ZBTB39 Gene:

Hs.591025
genes like me logo Genes that share expression patterns with ZBTB39: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB39 Gene

Orthologs for ZBTB39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB39 34 35
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia ZBTB39 34 35
  • 90.48 (n)
dog
(Canis familiaris)
Mammalia ZBTB39 34
  • 89.78 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb39 34
  • 86.37 (n)
mouse
(Mus musculus)
Mammalia Zbtb39 34 16 35
  • 86.03 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB39 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB39 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB39 34
  • 75.62 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB39 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb39 34
  • 63.49 (n)
Str.4668 34
zebrafish
(Danio rerio)
Actinopterygii LOC565015 34
  • 51.01 (n)
ZBTB39 35
  • 37 (a)
OneToOne
Species where no ortholog for ZBTB39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB39 Gene

ENSEMBL:
Gene Tree for ZBTB39 (if available)
TreeFam:
Gene Tree for ZBTB39 (if available)

Paralogs for ZBTB39 Gene

Paralogs for ZBTB39 Gene

genes like me logo Genes that share paralogs with ZBTB39: view

Variants for ZBTB39 Gene

Sequence variations from dbSNP and Humsavar for ZBTB39 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1045199 -- 56,998,383(+) TTGAG(A/G)TCTGT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111364260 -- 57,000,988(+) CTCCA(C/T)CACAG utr-variant-3-prime
rs111802991 -- 57,004,276(+) GCAGG(A/G)GTGTC reference, synonymous-codon
rs112935646 -- 57,004,301(+) TTGGC(A/G)GTGGT reference, missense
rs116009383 -- 57,007,298(+) CCACC(C/T)ACCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZBTB39 Gene

Variant ID Type Subtype PubMed ID
nsv832428 CNV gain 17160897
nsv559022 CNV loss 21841781
nsv482992 CNV gain+loss 15286789
esv3580285 CNV loss 25503493

Variation tolerance for ZBTB39 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB39 Gene

Disorders for ZBTB39 Gene

Relevant External Links for ZBTB39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB39

No disorders were found for ZBTB39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB39 Gene

Publications for ZBTB39 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZBTB39 Gene

Sources for ZBTB39 Gene

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