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ZBTB39 Gene

protein-coding   GIFtS: 49

GC12M055679
zinc finger and BTB domain containing 39
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for ZBTB39

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
KIAA0352 1, 2, 3
Descriptions
zinc finger and BTB domain containing 39 2
External Ids
HGNC: 290141
Entrez Gene: 98802
UniProtKB: O150603
Ensembl: ENSG000001668607
Search outside databases for aliases for ZBTB39 gene

Summaries
for ZBTB39

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT39_HUMAN, O15060
Function: May be involved in transcriptional regulation

Genomic Location
for ZBTB39

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB39 gene  

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

ZBTB39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M055679:     (about GC identifiers)

Start:
 55,678,885 bp from pter
End:
 55,686,497 bp from pter
Size:
 7,613 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  

Proteins
for ZBTB39

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ZBT39_HUMAN, O15060 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 39  
Size: 712 amino acids; 79001 Da
Subcellular location: Nucleus (Potential)

REFSEQ proteins: NP_055645.1  

ENSEMBL proteins: 
ENSP00000300101 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ZBTB39)
Human Recombinant Proteins from Abnova (ZBTB39)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
About this table

Antibodies for ZBTB39: 
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Sigma-Aldrich Antibodies for ZBTB39
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Antibodies from Abcam (ZBTB39), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (ZBTB39)
Novus Biologicals Antibody for ZBTB39

Assays for ZBTB39: 
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Browse Kits and Assays available from Millipore
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Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for ZBTB39

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro domains/families:
 IPR000210 BTB/POZ-like
 IPR015880 Znf_C2H2-like
 IPR013069 BTB_POZ
 IPR007087 Znf_C2H2


   GeneDecks  ZBTB39 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry O15060

ProtoNet protein and cluster: O15060

2 Blocks protein families:
IPB000210 BTB/POZ domain
IPB007086 C2H2-type zinc finger signature


UniProtKB/Swiss-Prot: ZBT39_HUMAN, O15060
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 1 BTB (POZ) domain
Similarity: Contains 8 C2H2-type zinc fingers

Gene Function
for ZBTB39

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB39)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZBTB39)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014830

              Applied Biosystems Silencer® siRNAs for ZBTB39

              Sigma-Aldrich siRNA and siRNA Panels for ZBTB39  
                     Sigma-Aldrich shRNA for ZBTB39  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014830
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014830
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_014830 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_014830

UniProtKB/Swiss-Prot: ZBT39_HUMAN, O15060
Function: May be involved in transcriptional regulation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
GO:0005515 protein binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

Pathways & Interactions
for ZBTB39

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
About this table

Drugs & Compounds
for ZBTB39

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB39

Transcripts
for ZBTB39

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB39)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZBTB39)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014830

              Sigma-Aldrich siRNA and siRNA Panels for ZBTB39  
                     Sigma-Aldrich shRNA for ZBTB39  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_014830  

REFSEQ mRNAs for ZBTB39 gene: 

NM_014830.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_014830  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014830
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014830
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_014830 

Additional cDNA sequence: 

AB002350.1 AK292468.1 BC140890.1 BC146867.1 BC152461.1 

3 DOTS entries:

DT.212953  DT.100745224  DT.121199002 

24/47 AceView cDNA sequences (see all 47 ):

BQ186782 AA285021 Z44541 AU131263 AI859758 BG105447 BM755860 AI685473 
CB265877 CB150427 AA442375 AU125325 AB002350 CK299899 M85739 AU117582 
AL040120 AI304644 AA678303 AA922676 AW069817 BU855430 AV659957 CA423679 

highest scoring ESTs for ZBTB39:

AB002350 BX492440 AA285021 AA349071 AA442375 AA454122 AA678303 AA749272 AA889537 AA903905 

Unigene Cluster for ZBTB39:

Zinc finger and BTB domain containing 39
Hs.591025  [show with all ESTs]
Unigene Representative Sequence: BC152461


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000300101  

Expression
for ZBTB39

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB39 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB39

1 / 2 / 3

3 probe-sets matching ZBTB39 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

38532_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB002350 1.00 1.00 1.00 1

205256_at2, 3 U133-A 2 1.00 0.95 -- -- NM_014830 0.60 1.00 0.82 1

205256_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GCTAGTTAGG

SOURCE GeneReport for Unigene cluster: Hs.591025

Expression variation in blood from EXPOLDB for ZBTB39

Orthologs
for ZBTB39

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for ZBTB39 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 ZBTB391   -- zinc finger and BTB domain containing 39 87.83(n)
90.16(a)		 481121  XM_843899.1  XP_848992.1 
chimpanzee
(Pan troglodytes)		 ZBTB391   -- zinc finger and BTB domain containing 39 99.2(n)
99.16(a)		 467041  XM_522441.2  XP_522441.2 
cow
(Bos taurus)		 ZBTB391   -- zinc finger and BTB domain containing 39 90.43(n)
93.35(a)		 510453  XM_587594.3  XP_587594.2 
rat
(Rattus norvegicus)		 Zbtb391   -- zinc finger and BTB domain containing 39 86.32(n)
89.56(a)		 299510  XM_234781.3  XP_234781.1 
mouse
(Mus musculus)		 Zbtb391, 5 105
 zinc finger and BTB domain containing 391, 5 85.98(n)1
88.89(a)1		 3200801  NM_198035.11  NP_932152.11 
 AI4157025  AK0330195  (see all 13)
About this table        Species with no ortholog for ZBTB39

ENSEMBL Gene Tree for ZBTB39

Paralogs
for ZBTB39

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ZBTB39 gene
ZBTB322  ZBTB162  

SNPs/Variants
for ZBTB39

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/41 NCBI SNPs in ZBTB39 are shown (see all 41 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 34)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs38030181,2
A,C,F,H55680390(-) AACTTG/TGCCCT 1 -- ut31 ese34Minor allele frequency- T:0.09EU EA WA 412
rs7543981,2
A,C,F55681945(+) TCAGAT/GACATC 1 -- ut31 ese35Minor allele frequency- G:0.14MN NA EA 546
rs37415761,2
F,H55682904(-) TCCCCC/GCTGAC 1 P/A mis1 trp34Minor allele frequency- G:0.02EU EA WA 406
rs37415781,2
F,H55680902(-) TGCTTC/GTCCCC 1 -- ut31 ese35Minor allele frequency- G:0.08EA EU WA 1908
rs37415771,2
F,H55682007(-) TTGATA/GTAGTC 1 -- ut315Minor allele frequency- G:0.02EA EU WA 1170
rs37591381,2
H55687378(-) CATGAC/TGAAGA 1 -- ng315Minor allele frequency- T:0.01EA EU WA 1150
rs23717171,2
C55680921(-) CCATCC/TTTGTT 1 -- ut310--------
rs29302021,2
H55684698(-) CTTCAG/CAACTC 1 Q/E mis1 ese34Minor allele frequency- C:0.00EU EA WA 406
rs7488941,2
A,C,F55684561(-) ACCAGC/TACCAG 1 S/S syn1 ese33Minor allele frequency- T:0.05MN NA EA 366
rs40163381,2
A,C,F,H55685282(-) TGTCCA/GAGGGA 1 -- int14Minor allele frequency- G:0.10EU EA WA 418
About this table

HapMap Linkage Disequilibrium images for ZBTB39 (up to first 250kb)

Disorders & Mutations
for ZBTB39

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for ZBTB39

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for ZBTB39

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

1 PubMed article for ZBTB39 gene:

Search for ZBTB39

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing ZBTB39

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 9880 HGNC: 29014 AceView: KIAA0352 Ensembl:ENSG00000166860 euGenes: HUgn9880
ECgene: ZBTB39 H-InvDB: ZBTB39

Other Databases showing ZBTB39

(According to HUGE)
About This Section
HUGE: KIAA0352

Specialized Databases showing ZBTB39

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for ZBTB39

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for ZBTB39

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ZBTB39:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Antibodies for ZBTB39

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