ZBTB39 Gene
protein-coding GIFtS: 43
GCID: GC12M057392
|
|
zinc finger and BTB domain containing 39
| |
Aliases
for ZBTB39 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 391 2 | | ZNF9221 2 | | KIAA03521 3 | | Zinc Finger And BTB Domain-Containing Protein 392 |
Export aliases for ZBTB39 gene to outside databasesPrevious GC identifers: GC12M055679 GC12M054431 |
Summaries
for ZBTB39 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT39_HUMAN, O15060Function: May be involved in transcriptional regulation
|
Genomic Views
for ZBTB39 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB39 gene promoter:
Nkx3-1 Nkx3-1 v1 CUTL1 Meis-1b C/EBPalpha AREB6 CP2 Meis-1a TGIF Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB39
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB39 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3ZBTB39 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M057392: view genomic region
(about GC identifiers)
Start:
|
57,392,618 bp from pter |
End:
|
57,400,230 bp from pter |
Size:
|
7,613 bases |
Orientation:
|
minus strand |
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Proteins
for ZBTB39 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT39_HUMAN, O15060 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 39 Size: 712 amino acids; 79001 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA20809.2; Type=Erroneous initiation;
Secondary accessions: A7MD38 Q9UD98Explore the universe of human proteins at neXtProt for ZBTB39: NX_O15060
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15060
ZBTB39 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055645.1
ENSEMBL proteins: ENSP00000300101
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZBTB39 for ontologies About GeneDecksing
ZBTB39 Antibody Products:
Assay Products for ZBTB39: |
Protein
Domains /
Families
for ZBTB39 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB39 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O15060ProtoNet protein and cluster: O15060 2 Blocks protein families: IPB000210 BTB/POZ domain IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZBT39_HUMAN, O15060Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 8 C2H2-type zinc fingers |
Function
for ZBTB39 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT39_HUMAN, O15060Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB39 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB39
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB39 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZBTB39 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZBTB39:
|
Pathways & Interactions
for ZBTB39 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB39
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ZBTB39 (ENSP000003001014) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB39 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB39 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB39
Search CenterWatch for drugs/clinical trials and news about ZBTB39 / ZBT39
|
Transcripts
for ZBTB39 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB39 gene: NM_014830.2 Unigene Cluster for ZBTB39: Zinc finger and BTB domain containing 39 Hs.591025 [show with all ESTs]Unigene Representative Sequence: NM_0148301 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000300101(uc001sml.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB39 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB39
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB39 (NM_014830) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB39 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB39 |
Additional cDNA sequence: AB002350.1 AK292468.1 BC140890.1 BC146867.1 BC152461.1 3 DOTS entries: DT.212953 DT.100745224 DT.121199002 24/47 AceView cDNA sequences (see all 47): AL040120 AU131263 AA922676 CB150427 Z44541 BG105447 BQ186782 AW069817 AU117582 AI685473 AU125325 BM755860 AI304644 M85739 AA285021 AI859758 AA442375 AB002350 CK299899 AA678303 CB265877 BU855430 AI460081 AI283505
GeneLoc Exon Structure
|
Expression
for ZBTB39 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB39 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTAGTTAGG
About this image
See ZBTB39 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB39
SOURCE GeneReport for Unigene cluster: Hs.591025
SABiosciences Custom PCR Arrays for ZBTB39
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB39
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB39 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB39 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB39 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB39 |
Orthologs
for ZBTB39 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB39 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008587341 |
zinc finger and BTB domain-containing protein 39-like |
75.62(n)
78.29(a) |
|
100858734 XM_003643870.1 XP_003643918.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ZBTB396 |
-- |
78(a) |
1 ↔ 1 |
2(95280752-95282851) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.46682 |
Transcribed sequence with weak similarity to protein more |
76.48(n) |
|
AL847604.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5650151 |
zinc finger and BTB domain-containing protein 39-like |
50.29(n)
42.22(a) |
|
565015 XM_688326.5 XP_693418.2 |
ENSEMBL Gene Tree for ZBTB39 (if available)
TreeFam Gene Tree for ZBTB39 (if available) |
Paralogs
for ZBTB39 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB39 gene
- ZBTB322 ZBTB162
ZBTB39 for paralogs About GeneDecksing
|
Genomic Variants
for ZBTB39 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB39 (57392618 - 57400230 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBTB39: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB39 |
|
Disorders
/ Diseases
for ZBTB39 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZBTB39 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB39 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZBTB39) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- 3,400 new expressed sequence tags identify diversity of transcripts in human brain. (PubMed id 8358434)2 Adams M.D.... Venter J.C. (1993)
|
External Searches for ZBTB39 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB39 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB39 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZBTB39 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB39 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB39 gene:
Search GeneIP for patents involving ZBTB39
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB39 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | ZBTB39 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB39 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB39 |
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