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Aliases & Descriptions for ZBTB38
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CIBZ 1, 2 | | FLJ22332 2 | | FLJ31131 2 | | FLJ35036 1, 2 |
| | | Descriptions |
|---|
| zinc finger and BTB domain containing 38 2 |
|
| | Search outside databases for aliases for ZBTB38 genePrevious GC identifer: GC03P142628 |
Summaries for ZBTB38(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Function: Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity) |
Genomic Location for ZBTB38
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ZBTB38 gene 
Entrez Gene cytogenetic band: 3q23 Ensembl cytogenetic band: 3q23 HGNC cytogenetic band: 3q23ZBTB38 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P142525:
(about GC identifiers)
Start:
|
142,525,745 bp from pter |
End:
|
142,651,324 bp from pter |
Size:
|
125,580 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000003.10 NT_005612.15
| Proteins for ZBTB38
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 38 Size: 1195 amino acids; 134257 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAC03868.1; Type=Frameshift; Positions=147;Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001073881.2
ENSEMBL proteins: ENSP00000372635
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ZBTB38: Assays for ZBTB38: | Protein
Domains/ Families for ZBTB38(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8NAP3
ProtoNet protein and cluster: Q8NAP3 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 10 C2H2-type zinc fingers | Gene Function for ZBTB38
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): XM_172341
Applied Biosystems Silencer® siRNAs for ZBTB38
Sigma-Aldrich siRNA and siRNA Panels for ZBTB38  Sigma-Aldrich shRNA for ZBTB38  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001080412                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001080412                                  untagged cDNA clones in CMV expression vector (see all 4): AL833148 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001080412
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Function: Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity)4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ZBTB38
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
ISS | -- | About this table
|
Drugs & Compounds for ZBTB38(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ZBTB38
|
Transcripts for ZBTB38(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): XM_172341
Sigma-Aldrich siRNA and siRNA Panels for ZBTB38  Sigma-Aldrich shRNA for ZBTB38  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001080412 REFSEQ mRNAs for ZBTB38 gene: NM_001080412.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001080412               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001080412                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001080412                                  untagged cDNA clones in CMV expression vector (see all 4): AL833148  Additional cDNA sequence: AK025985.1 AK055693.1 AK092355.1 AK094201.1 AK302568.1 AK307452.1 AK311479.1 AK311501.1 AL833148.1 BC008901.2 BC015444.1 BC022936.1 BC051734.1 BC072415.1 BC107745.1 CR596380.1 12 DOTS entries: DT.455936 DT.100726896 DT.120898500 DT.100009025 DT.100811255 DT.120898448 DT.95253719 DT.120898403 DT.120898470 DT.102843102 DT.120898435 DT.95096094 24/244 AceView cDNA sequences (see all 244
):AW024367 BX107719 AW085625 BM989230 BM756304 Z44269 BM785229 AI383204 AW070974 BP378214 BC008901 BC051734 AI219217 R32881 CA866923 BC022936 BC015444 AI740757 AA258994 AK055693 BM682234 AL045978 AI470490 CB178638
highest scoring ESTs for ZBTB38:AI376649 AI928164 W90534 AI741178 AA176404 AA178877 AA196420 AA258171 AA281121 AA302675 Unigene Cluster for ZBTB38: Zinc finger and BTB domain containing 38 Hs.715534 [show with all ESTs]Unigene Representative Sequence: NM_001080412
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000321464
|
Expression for ZBTB38
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZBTB38 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB38
1 / 2 / 3 13 probe-sets matching ZBTB38 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACCAACTAGA
SOURCE GeneReport for Unigene cluster: Hs.715534
|
Orthologs for ZBTB38
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZBTB38 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for ZBTB38
ENSEMBL Gene Tree for ZBTB38 | Paralogs for ZBTB38(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ZBTB38 gene
- ZNF2952 ZFP1612 ZBTB332 ZBTB42
|
SNPs/Variants for ZBTB38(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Polymorphism: Genetic variations in ZBTB38 influences stature as a quantitative trait type 10 (STQTL10) [MIM:612221]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits
HapMap Linkage Disequilibrium images for ZBTB38 (up to first 250kb)
|
Disorders & Mutations for ZBTB38
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612218
Human Genome Epidemiology Navigator: ZBTB38 (3 documents)
|
Medical News for ZBTB38(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ZBTB38 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for ZBTB38 gene (see all 13
):- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)3, 4 Muzny D.M....Gibbs R.A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)2, 3 Strausberg R.L....Marra M.A. (2002)
- Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)3 Sovio U....Jarvelin M.R. (2009)
- Common variants in the GDF5-UQCC region are associated with variation in human height. (PubMed id 18193045)3 Sanna S....Mohlke K.L. (2008)
- RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. (PubMed id 18851979)3 Chibi M....Pugh D.J. (2008)
- Genome-wide association analysis identifies 20 loci that influence adult height. (PubMed id 18391952)3 Weedon M.N....Frayling T.M. (2008)
- Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)3 Gudbjartsson D.F....Stefansson K. (2008)
- Identification of ten loci associated with height highlights new biological pathways in human growth. (PubMed id 18391950)3 Lettre G....Hirschhorn J.N. (2008)
|
Search for ZBTB38
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZBTB38
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZBTB38
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB38(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ZBTB38(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ZBTB38:

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Incremental update: 13 Oct 2009
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