ZBTB38 Gene
protein-coding GIFtS: 47
GCID: GC03P141043
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|
zinc finger and BTB domain containing 38
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Aliases
for ZBTB38 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 381 2 | | CIBZ1 2 | | ZNF9211 2 | | FLJ350361 | | Zinc Finger And BTB Domain-Containing Protein 382 |
Export aliases for ZBTB38 gene to outside databasesPrevious GC identifers: GC03P142628 GC03P142525 GC03P138418 |
Summaries
for ZBTB38 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZBTB38:
The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encodedprotein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein hasbeen associated with apoptosis in some cell types. (provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Function: Acts as a transcriptional activator. May be involved in the differentiation and/or survival of latepostmitotic neurons (By similarity)
|
Genomic Views
for ZBTB38 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB38 gene promoter:
SRF SRF (504 AA) Bach2 FOXO3 Lmo2 STAT5A FOXO3b MEF-2A FOXO3a aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB38
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB38 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q23 Ensembl cytogenetic band: 3q23 HGNC cytogenetic band: 3q23ZBTB38 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P141043: view genomic region
(about GC identifiers)
Start:
|
141,043,055 bp from pter |
End:
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141,168,634 bp from pter |
Size:
|
125,580 bases |
Orientation:
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plus strand |
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Proteins
for ZBTB38 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 38 Size: 1195 amino acids; 134257 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAC03868.1; Type=Frameshift; Positions=147;
Secondary accessions: D3DNF6Explore the universe of human proteins at neXtProt for ZBTB38: NX_Q8NAP3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NAP3
ZBTB38 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073881.2
ENSEMBL proteins: ENSP00000426931 ENSP00000421037 ENSP00000422051 ENSP00000426288 ENSP00000424254 ENSP00000426387 ENSP00000425705 ENSP00000422347 ENSP00000422757 ENSP00000406955 ENSP00000422081 ENSP00000422894 ENSP00000372635
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZBTB38 for ontologies About GeneDecksing
ZBTB38 Antibody Products:
Assay Products for ZBTB38: |
Protein
Domains /
Families
for ZBTB38 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB38 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8NAP3ProtoNet protein and cluster: Q8NAP3 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 10 C2H2-type zinc fingers |
Function
for ZBTB38 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Function: Acts as a transcriptional activator. May be involved in the differentiation and/or survival of latepostmitotic neurons (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB38 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB38
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB38 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- | | GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
ISS | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZBTB38 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZBTB38 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB38
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ZBTB38 (Q8NAP33 ENSP000003726354) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
ISS | -- |
ZBTB38 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB38 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB38
Search CenterWatch for drugs/clinical trials and news about ZBTB38 / ZBT38
|
Transcripts
for ZBTB38 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB38 gene (2 alternative transcripts): NM_001080412.2 NM_152535.1 Unigene Cluster for ZBTB38: Zinc finger and BTB domain containing 38 Hs.518301 [show with all ESTs]Unigene Representative Sequence: NM_00108041218/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000509842 ENST00000513619 ENST00000512276 ENST00000507657 ENST00000507722
ENST00000512327 ENST00000513249 ENST00000503809 ENST00000513258 ENST00000506623
ENST00000509883 ENST00000514251(uc003etw.3 uc010hun.3 uc010huo.3 uc003ety.3 uc010hup.3)
ENST00000510338 ENST00000504673 ENST00000513570 ENST00000441582 ENST00000510726
ENST00000509813
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB38 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB38
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB38 (NM_001080412) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB38 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB38 |
Additional cDNA sequence: AK025985.1 AK055693.1 AK092355.1 AK094201.1 AK302568.1 AK307452.1 AK311479.1 AK311501.1 AL833148.1 BC008901.2 BC015444.1 BC022936.1 BC051734.1 BC072415.1 BC107745.1 12 DOTS entries: DT.455936 DT.100726896 DT.120898500 DT.100009025 DT.100811255 DT.120898448 DT.95253719 DT.120898403 DT.120898470 DT.102843102 DT.120898435 DT.95096094 24/244 AceView cDNA sequences (see all 244): BP363249 AA463731 CA391052 AI928164 CB178638 AA480309 AW024367 AW070974 AI143149 AL833148 AI470490 CD676777 BM931073 R32881 AI219217 AA353316 AK055693 AI742334 AA258994 BC008901 AK025985 BC022936 AW192379 BM984007
GeneLoc Exon Structure
|
Expression
for ZBTB38 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB38 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCAACTAGA
About this image
See ZBTB38 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB38
SOURCE GeneReport for Unigene cluster: Hs.518301
SABiosciences Custom PCR Arrays for ZBTB38
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB38
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB38 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB38 |
Orthologs
for ZBTB38 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB38 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for ZBTB38 (if available)
TreeFam Gene Tree for ZBTB38 (if available) |
Paralogs
for ZBTB38 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB38 gene
- ZBTB212 ZBTB332 ZBTB42
18/95 SIMAP similar genes for ZBTB38 using alignment to 13 protein entries: ZBT38_HUMAN (see all proteins)
(see all similar genes):KLHL36 ZNF295 ZBTB4 ZBTB21 ZBTB20 ZBTB7C
ZBTB14 HIC1 ZBTB10 BACH2 KLHL2 KLHL32
PLZF ZFS-5 ZNF410 MYNN kr-znf3 BCL6B
ZBTB38 for paralogs About GeneDecksing
|
Genomic Variants
for ZBTB38 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Polymorphism: Genetic variations in ZBTB38 define the stature quantitative trait locus 10 (STQTL10) [MIM:612221]. Adultheight is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait forstudying genetic influence on quantitative traits
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB38 (141043055 - 141168634 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZBTB38
1 Indel: 59093 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB38 |
|
Disorders
/ Diseases
for ZBTB38 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBTB38 for disorders About GeneDecksing
OMIM gene information: 612218
OMIM disorders: --
3  diseases for ZBTB38: About MalaCardspediatric crohns disease crohn's disease neuronitis
Human Genome Epidemiology (HuGE) Navigator: ZBTB38 (8 documents)
Export disorders for ZBTB38 gene to outside databases
|
Publications
for ZBTB38 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB38 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with ZBTB38) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PubMed id 22210626)1 Mead S....Collinge J. (2012)
- A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
- Alternative splicing of human height-related zinc fin ger and BTB domain-containing 38 gene through Alu exonization. (PubMed id 21188497)1 Hong K.W....Oh B. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1 N'Diaye A....Haiman C.A. (2011)
- Seven prostate cancer susceptibility loci identified b y a multi-stage genome-wide association study. (PubMed id 21743467)1 Kote-Jarai Z.... . (2011)
|
External Searches for ZBTB38 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB38 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB38 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB38 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB38 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB38 gene:
Search GeneIP for patents involving ZBTB38
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB38 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBTB38 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB38 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB38 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB38 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB38 |
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