V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

ZBTB38 Gene

protein-coding   GIFtS: 47

GC03P142525
zinc finger and BTB domain containing 38
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
CIBZ 1, 2
FLJ22332 2
FLJ31131 2
FLJ35036 1, 2
Descriptions
zinc finger and BTB domain containing 38 2
External Ids
HGNC: 266361
Entrez Gene: 2534612
UniProtKB: Q8NAP33
Ensembl: ENSG000001773117
Search outside databases for aliases for ZBTB38 gene

Previous GC identifer: GC03P142628

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3
Function: Acts as a transcriptional activator. May be involved in the differentiation and/or
survival of late postmitotic neurons (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB38 gene  

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

ZBTB38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P142525:     (about GC identifiers)

Start:
142,525,745 bp from pter
End:
142,651,324 bp from pter
Size:
125,580 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 38  
Size: 1195 amino acids; 134257 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAC03868.1; Type=Frameshift; Positions=147;

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001073881.2  

    ENSEMBL proteins: 
    ENSP00000372635 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZBTB38)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus ISS--
    About this table

    Antibodies for ZBTB38: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZBTB38
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZBTB38), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ZBTB38

    Assays for ZBTB38: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ


       GeneDecks  ZBTB38 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8NAP3

    ProtoNet protein and cluster: Q8NAP3

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 10 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB38)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): XM_172341

                  Applied Biosystems Silencer® siRNAs for ZBTB38

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB38  
                         Sigma-Aldrich shRNA for ZBTB38  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001080412
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001080412
                                     untagged cDNA clones in CMV expression vector (see all 4): AL833148 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001080412

    UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3
    Function: Acts as a transcriptional activator. May be involved in the differentiation and/or
    survival of late postmitotic neurons (By similarity)

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity ISS--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB38

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB38)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): XM_172341

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB38  
                         Sigma-Aldrich shRNA for ZBTB38  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001080412  

    REFSEQ mRNAs for ZBTB38 gene: 

    NM_001080412.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001080412  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001080412
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001080412
                                     untagged cDNA clones in CMV expression vector (see all 4): AL833148 

    Additional cDNA sequence: 

    AK025985.1 AK055693.1 AK092355.1 AK094201.1 AK302568.1 AK307452.1 AK311479.1 AK311501.1 
    AL833148.1 BC008901.2 BC015444.1 BC022936.1 BC051734.1 BC072415.1 BC107745.1 CR596380.1 

    12 DOTS entries:

    DT.455936  DT.100726896  DT.120898500  DT.100009025  DT.100811255  DT.120898448  DT.95253719  DT.120898403 
    DT.120898470  DT.102843102  DT.120898435  DT.95096094 

    24/244 AceView cDNA sequences (see all 244 ):

    AW024367 BX107719 AW085625 BM989230 BM756304 Z44269 BM785229 AI383204 
    AW070974 BP378214 BC008901 BC051734 AI219217 R32881 CA866923 BC022936 
    BC015444 AI740757 AA258994 AK055693 BM682234 AL045978 AI470490 CB178638 

    highest scoring ESTs for ZBTB38:

    AI376649 AI928164 W90534 AI741178 AA176404 AA178877 AA196420 AA258171 AA281121 AA302675 

    Unigene Cluster for ZBTB38:

    Zinc finger and BTB domain containing 38
    Hs.715534  [show with all ESTs]
    Unigene Representative Sequence: NM_001080412


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000321464  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB38 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB38

    1 / 2 / 3

    13 probe-sets matching ZBTB38 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    53604_at2, 3 U95-B 1 1.00 1.00 0.54 0.95 AI928164 1.00 1.00 1.00 1

    56959_at2, 3 U95-B 1 1.00 1.00 0.91 0.94 AI376649 1.00 1.00 1.00 1

    50266_at2, 3 U95-B 1 1.00 1.00 0.84 1.59 AI741178 1.00 0.90 0.95 1

    67599_at2, 3 U95-E 1 1.00 1.00 0.38 0.56 W90534 1.00 1.00 1.00 1

    225512_at2, 3 U133-B 1 1.00 1.00 -- -- AI005245 0.80 0.88 0.84 1

    219221_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024724 0.20 1.00 0.72 1

    230754_at2, 3 U133-B 1 1.00 1.00 -- -- AI928164 1.00 1.00 1.00 1

    236557_at2, 3 U133-B 1 0.64 1.00 -- -- AW085625 0.80 1.00 0.91 1

    225512_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    219221_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1558733_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    230754_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    236557_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACCAACTAGA

    SOURCE GeneReport for Unigene cluster: Hs.715534
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZBTB38 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZBTB381   -- zinc finger and BTB domain containing 38 87.42(n)
    89.26(a)
    477096  XM_860485.1  XP_865578.1 
    chimpanzee
    (Pan troglodytes)
    ZBTB381   -- zinc finger and BTB domain containing 38 99.47(n)
    99.41(a)
    460740  XM_516788.2  XP_516788.2 
    cow
    (Bos taurus)
    ZBTB381   -- zinc finger and BTB domain containing 38 87.3(n)
    89.53(a)
    539843  XM_589799.3  XP_589799.3 
    rat
    (Rattus norvegicus)
    Zbtb381   -- zinc finger and BTB domain containing 38 82.06(n)
    81.92(a)
    315936  NM_001012471.1  NP_001012489.1 
    mouse
    (Mus musculus)
    Zbtb381, 5 95
    zinc finger and BTB domain containing 381, 5 82.28(n)1
    81.7(a)1
    2450071  NM_175537.31  NP_780746.21 
     AK0444675  AK0540965  (see all 9)
    About this table        Species with no ortholog for ZBTB38

    ENSEMBL Gene Tree for ZBTB38
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZBTB38 gene
    ZNF2952  ZFP1612  ZBTB332  ZBTB42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3
    Polymorphism: Genetic variations in ZBTB38 influences stature as a quantitative trait type 10
    (STQTL10) [MIM:612221]. Adult height is an easily observable and highly heritable complex
    continuous trait. Because of this, it is a model trait for studying genetic influence on
    quantitative traits


    10/483 NCBI SNPs in ZBTB38 are shown (see all 483 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 104)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs67778861,2
    A,C,F,H142524912(+) CATTGC/TGTAAA 1 -- ng514Minor allele frequency- T:0.20EU EA WA 416
    --
    rs67780101,2
    A,C,F,H142525053(+) GCAGGA/CCTGGA 1 -- ng514Minor allele frequency- C:0.42EU EA WA 414
    rs67647691,2
    A,C,F,H142582970(+) TGGAGG/AGTAAC 1 -- ut514Minor allele frequency- A:0.45EU EA WA 414
    rs67845531,2
    A,C,F,H142651633(+) TGGGTG/TTGCAA 1 -- ng314Minor allele frequency- T:0.10EU EA WA 418
    --
    rs15828741,2
    A,C,F,H142597909(-) agatgA/Ggactg 1 -- ut514Minor allele frequency- G:0.50EU EA WA 416
    --
    rs18638681,2
    C,F,H,O142570313(-) CTGAAG/ACCCAG 1 -- ut517Minor allele frequency- A:0.46MN EU EA WA NA 784
    --
    rs76426671,2
    A,C,F,H142523749(+) TAAAAA/CATCTT 1 -- ng514Minor allele frequency- C:0.12EU EA WA 420
    rs119187641,2
    C,F,H142650616(+) AATTCG/AACCTC 1 -- ut317Minor allele frequency- A:0.10EU EA WA NA 560
    rs168514351,2
    C,F,H142644875(+) ATTTTG/TCCAGG 1 S/A mis1 ese312Minor allele frequency- N:0.00NA EU EA WA 1056
    rs37328671,2
    C,F,H142646345(+) ATATTG/ACTGAA 1 T/A mis18Minor allele frequency- A:0.02EU EA WA 840
    About this table

    HapMap Linkage Disequilibrium images for ZBTB38 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 612218

    Human Genome Epidemiology Navigator: ZBTB38 (3 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for ZBTB38 gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 253461 HGNC: 26636 AceView: FLJ35036 Ensembl:ENSG00000177311 euGenes: HUgn253461
    ECgene: ZBTB38 H-InvDB: ZBTB38
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB38:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB38-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ZBTB38 Antibodies for ZBTB38
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZBTB38 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Search for Antibodies
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (ZBTB38)
     Antibodies (ZBTB38)
     Search OriGene for ZBTB38
     Search Tocris compounds for ZBTB38




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for ZBTB38

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    ZBTB38 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com