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Aliases for ZBTB38 Gene

Aliases for ZBTB38 Gene

  • Zinc Finger And BTB Domain Containing 38 2 3
  • Zinc Finger And BTB Domain-Containing Protein 38 3
  • Protein Phosphatase 1, Regulatory Subunit 171 3
  • Regulatory Subunit 171 2
  • Protein Phosphatase 1 2
  • PPP1R171 3
  • ZNF921 3
  • CIBZ 3

External Ids for ZBTB38 Gene

Previous GeneCards Identifiers for ZBTB38 Gene

  • GC03P142628
  • GC03P142525
  • GC03P141043
  • GC03P138418

Summaries for ZBTB38 Gene

Entrez Gene Summary for ZBTB38 Gene

  • The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq, Jun 2010]

GeneCards Summary for ZBTB38 Gene

ZBTB38 (Zinc Finger And BTB Domain Containing 38) is a Protein Coding gene. Diseases associated with ZBTB38 include kuru. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZBTB7B.

UniProtKB/Swiss-Prot for ZBTB38 Gene

  • Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB38 Gene

Genomics for ZBTB38 Gene

Regulatory Elements for ZBTB38 Gene

Genomic Location for ZBTB38 Gene

Start:
141,324,213 bp from pter
End:
141,449,792 bp from pter
Size:
125,580 bases
Orientation:
Plus strand

Genomic View for ZBTB38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB38 Gene

Proteins for ZBTB38 Gene

  • Protein details for ZBTB38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAP3-ZBT38_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 38
    Protein Accession:
    Q8NAP3
    Secondary Accessions:
    • D3DNF6

    Protein attributes for ZBTB38 Gene

    Size:
    1195 amino acids
    Molecular mass:
    134257 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03868.1; Type=Frameshift; Positions=147; Evidence={ECO:0000305};

neXtProt entry for ZBTB38 Gene

Proteomics data for ZBTB38 Gene at MOPED

Post-translational modifications for ZBTB38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB38 Gene

Domains for ZBTB38 Gene

Gene Families for ZBTB38 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZBTB38 Gene

Suggested Antigen Peptide Sequences for ZBTB38 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NAP3

UniProtKB/Swiss-Prot:

ZBT38_HUMAN :
  • Q8NAP3
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB38: view

Function for ZBTB38 Gene

Molecular function for ZBTB38 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).

Gene Ontology (GO) - Molecular Function for ZBTB38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003700 sequence-specific DNA binding transcription factor activity ISS --
GO:0005515 protein binding IPI 16354688
GO:0008327 methyl-CpG binding IDA 16354688
GO:0042803 protein homodimerization activity IDA 16354688
genes like me logo Genes that share ontologies with ZBTB38: view

Animal Model Products

CRISPR Products

miRNA for ZBTB38 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB38

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB38 Gene

Localization for ZBTB38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB38 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB38 Gene COMPARTMENTS Subcellular localization image for ZBTB38 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZBTB38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with ZBTB38: view

Pathways for ZBTB38 Gene

SuperPathways for ZBTB38 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 16354688
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with ZBTB38: view

No data available for Pathways by source for ZBTB38 Gene

Transcripts for ZBTB38 Gene

Unigene Clusters for ZBTB38 Gene

Zinc finger and BTB domain containing 38:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB38

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZBTB38

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB38 Gene

No ASD Table

Relevant External Links for ZBTB38 Gene

GeneLoc Exon Structure for
ZBTB38
ECgene alternative splicing isoforms for
ZBTB38

Expression for ZBTB38 Gene

mRNA expression in normal human tissues for ZBTB38 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZBTB38 Gene

SOURCE GeneReport for Unigene cluster for ZBTB38 Gene Hs.518301

genes like me logo Genes that share expressions with ZBTB38: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB38 Gene

Orthologs for ZBTB38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB38 35
  • 99.47 (n)
  • 99.41 (a)
ZBTB38 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB38 35
  • 87.3 (n)
  • 89.53 (a)
ZBTB38 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB38 35
  • 87.42 (n)
  • 89.26 (a)
ZBTB38 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb38 35
  • 82.28 (n)
  • 81.7 (a)
Zbtb38 16
Zbtb38 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB38 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB38 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb38 35
  • 82.06 (n)
  • 81.92 (a)
chicken
(Gallus gallus)
Aves ZBTB38 35
  • 68.64 (n)
  • 65.48 (a)
ZBTB38 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB38 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb38 35
  • 56.84 (n)
  • 50.28 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882192 35
  • 50.84 (n)
  • 44.11 (a)
zbtb38 36
  • 34 (a)
OneToOne
Species with no ortholog for ZBTB38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB38 Gene

ENSEMBL:
Gene Tree for ZBTB38 (if available)
TreeFam:
Gene Tree for ZBTB38 (if available)

Paralogs for ZBTB38 Gene

Paralogs for ZBTB38 Gene

genes like me logo Genes that share paralogs with ZBTB38: view

Variants for ZBTB38 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB38 Gene

Q8NAP3-ZBT38_HUMAN
Genetic variations in ZBTB38 define the stature quantitative trait locus 10 (STQTL10) [MIM:612221]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits

Sequence variations from dbSNP and Humsavar for ZBTB38 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs721338 -- 141,432,112(-) TCAGT(A/G)AGCTG intron-variant, utr-variant-5-prime
rs724016 -- 141,386,728(+) GACAC(A/G)TTCAT intron-variant, upstream-variant-2KB
rs726838 -- 141,353,824(-) CTCCA(A/T)CTACA intron-variant
rs765599 -- 141,405,639(+) AAATC(A/G/T)CAAGA intron-variant
rs767334 -- 141,386,180(+) ATACA(C/G)TATGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZBTB38 Gene

Variant ID Type Subtype PubMed ID
nsv829744 CNV Loss 17160897
nsv460871 CNV Loss 19166990
esv2678380 CNV Deletion 23128226
esv2662025 CNV Deletion 23128226
esv2673630 CNV Deletion 23128226
nsv819098 CNV Loss 19587683

Relevant External Links for ZBTB38 Gene

HapMap Linkage Disequilibrium report
ZBTB38
Human Gene Mutation Database (HGMD)
ZBTB38

Disorders for ZBTB38 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZBTB38 Gene including...

Search for ZBTB38 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZBTB38 Gene

Relevant External Links for ZBTB38

Genetic Association Database (GAD)
ZBTB38
Human Genome Epidemiology (HuGE) Navigator
ZBTB38
genes like me logo Genes that share disorders with ZBTB38: view

No data available for UniProtKB/Swiss-Prot for ZBTB38 Gene

Publications for ZBTB38 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Common variants in the GDF5-UQCC region are associated with variation in human height. (PMID: 18193045) Sanna S. … Mohlke K.L. (Nat. Genet. 2008) 3 48
  5. Down-regulation of CIBZ, a novel substrate of caspase-3, induces apoptosis. (PMID: 18375381) Oikawa Y. … Kawaichi M. (J. Biol. Chem. 2008) 2 3

Products for ZBTB38 Gene

  • antibodies-online peptides for ZBTB38
  • antibodies-online antibodies for ZBTB38
  • antibodies-online kits for ZBTB38

Sources for ZBTB38 Gene

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