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ZBTB37 Gene

protein-coding GIFtS: 49

GC01P172103

zinc finger and BTB domain containing 37
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
D430004I08Rik ^²
MGC2629 ^¹, ²
OTTHUMP00000035389 ^²

Descriptions
zinc finger and BTB domain containing 37 ^²

External Ids
HGNC: 28365¹
Entrez Gene: 84614²
UniProtKB: Q5TC79³
Ensembl: ENSG00000185278⁷

Search outside databases for aliases for ZBTB37 gene

Previous GC identifer: GC01P170569

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZBTB37 gene

Entrez Gene cytogenetic band: 1q25.1 Ensembl cytogenetic band: 1q25.1 HGNC cytogenetic band: 1q24.2

ZBTB37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P172103: (about GC identifiers)

Start:	172,103,843 bp from pter
End:	172,122,397 bp from pter
Size:	18,555 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 37

Size: 503 amino acids; 56055 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: Q5TC80 Q96M87 Q9BQ88

Alternative splicing: 3 isoforms: Q5TC79-1 Q5TC79-2 Q5TC79-3

REFSEQ proteins (2 alternative transcripts):

NP_001116242.1 NP_115911.1

ENSEMBL proteins:

ENSP00000356674 ENSP00000356677 ENSP00000331519 ENSP00000356675 ENSP00000356676

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZBTB37)
	Human Recombinant Proteins from Abnova (ZBTB37)

OriGene Purified Recombinant Human Protein: ZBTB37

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

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Antibodies for ZBTB37:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBTB37
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZBTB37), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZBTB37)
	Novus Biologicals Antibody for ZBTB37

Assays for ZBTB37:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q5TC79

ProtoNet protein and cluster: Q5TC79

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 3 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB37)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB37)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001122770

Applied Biosystems Silencer® siRNAs for ZBTB37

Sigma-Aldrich siRNA and siRNA Panels for ZBTB37

Sigma-Aldrich shRNA for ZBTB37

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZBTB37
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001122770
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001122770
untagged cDNA clones in CMV expression vector (see all 3): NM_001122770

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001122770

UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79

Function: May be involved in transcriptional regulation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB37

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB37)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB37)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001122770

Sigma-Aldrich siRNA and siRNA Panels for ZBTB37

Sigma-Aldrich shRNA for ZBTB37

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001122770 NM_032522

REFSEQ mRNAs for ZBTB37 gene (2 alternative transcripts):

NM_001122770.1 NM_032522.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001122770 NM_032522

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001122770
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001122770
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001122770

Additional cDNA sequence:

AF318371.1 AK057310.1 AK302696.1 BC003116.1 BC006315.2

4 DOTS entries:

DT.75149991 DT.40212237 DT.101975545 DT.95154505

21 AceView cDNA sequences:

BC003116 BF222713 AA833546 AW237081 AW204948 NM_032522 BC006315 AW590509

BI850982 AF318371 BF057788 AI954694 AW136373 AW139260 BX279840 AK057310

BF310280 BE262601 BI459864 CD708955 AV754688

highest scoring ESTs for ZBTB37:

AI954694 AK057310 AW204948 BC003116 BC006315 AA833546 AF318371 AV754688 AW136373 AW139260

Unigene Cluster for ZBTB37:

Zinc finger and BTB domain containing 37

Hs.668497 [show with all ESTs]

Unigene Representative Sequence: AK057310

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB37

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5
SP1:			-		-
SP2:					-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for ZBTB37

5 Ensembl transcripts including schematic representations:

ENST00000367701 ENST00000367704 ENST00000327714 ENST00000367702 ENST00000367703

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB37 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB37

¹ / ² / ³

5 probe-sets matching ZBTB37 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89738_at²^{, 3}	U95-D	1	1.00	1.00	1.00	1.00	AI954694	0.80	1.00	0.91	1
231547_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI954694	0.80	1.00	0.91	1
223953_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC003116	0.80	1.00	0.91	1
231547_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223953_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CATTTTTGTG

SOURCE GeneReport for Unigene cluster: Hs.668497

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ZBTB37 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
mouse (Mus musculus)	Zbtb37⁵	1	zinc finger and BTB domain containing 37	--	BC113763
zebrafish (Danio rerio)	Dr.16162²	--	Transcribed sequence with moderate similarity to protein more	74.45(n)	BG799142.1
African clawed frog (Xenopus laevis)	MGC53639²	--	hypothetical protein MGC53639	72.84(n)	BC044333.1

About this table Species with no ortholog for ZBTB37

ENSEMBL Gene Tree for ZBTB37

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB37 gene

ZBTB34² ZBTB22² ZBTB9² ZBTB43²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/39 NCBI SNPs in ZBTB37 are shown (see all 39 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 28)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1322775^1,2	A,C,F,H,O	172121921(+)	`CCCCTT/ATGAGC`	1	--	ut3¹ ese³		9		MN EA NA EU WA	2228
	rs1322772^1,2	A,F,H,O	172102381(+)	`CCCAAC/ATCACC`	1	--	ng5¹		8		EA NA MN EU WA	662
--	rs1951625^1,2	A,C,F,H	172103225(-)	`ctcgaC/Tatcgg`	1	--	ng5¹		4		EU EA WA	412
--	rs9660881^1,2	A,C,H	172103139(+)	`tagcaT/Cggtgg`	1	--	ng5¹		4		EU EA WA	388
	rs2984704^1,2	A,O	172102370(+)	`TCTCTA/CTGTTC`	1	--	ng5¹		0	--	--	--	--
	rs12090169^1,2	F,H	172102941(+)	`GTAAAG/AGATAC`	1	--	ng5¹		4		EU EA WA	390
--	rs17359906^1,2	F	172102817(+)	`GATCAG/AGTACA`	1	--	ng5¹		3		NA	130
--	rs16846520^1,2	C,F,H	172121831(+)	`GAGACA/GGTTGC`	1	T/T	syn¹		11		NA EU EA WA	938
	rs9425761^1,2	C,F,H	172106058(+)	`AACCAG/ATTGCG`	2	Q/Q	syn¹		9		EU EA WA NA	912
	rs36119794^1,2	C	172106530(+)	`CTGTGC/TTGGAT`	2	L/L	syn¹		1		NA	76

About this table

HapMap Linkage Disequilibrium images for ZBTB37 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: ZBTB37 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for ZBTB37 gene:

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)³ Trynka G....Wijmenga C. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 84614	HGNC: 28365	AceView: ZBTB37	Ensembl:ENSG00000185278	euGenes: HUgn84614
ECgene: ZBTB37	H-InvDB: ZBTB37

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBTB37
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB37:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB37-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB37		Antibodies for ZBTB37
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBTB37		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ZBTB37)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (ZBTB37)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ZBTB37

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ZBTB37 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for ZBTB37

Summaries
for ZBTB37

Genomic Location
for ZBTB37

Proteins
for ZBTB37

Protein Domains/
Families
for ZBTB37

Gene Function
for ZBTB37

Pathways & Interactions
for ZBTB37

Drugs & Compounds
for ZBTB37

Transcripts
for ZBTB37

Expression
for ZBTB37

Orthologs
for ZBTB37

Paralogs
for ZBTB37

SNPs/Variants
for ZBTB37

Disorders & Mutations
for ZBTB37

Medical News
for ZBTB37

Publications
for ZBTB37

Search for ZBTB37

Genome Databases showing ZBTB37

Other Databases showing ZBTB37

Specialized Databases showing ZBTB37

Licensable Technologies
for ZBTB37

Services
for ZBTB37

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB37 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor ZBTB37

Summariesfor ZBTB37

Genomic Locationfor ZBTB37

Proteinsfor ZBTB37

Protein Domains/Familiesfor ZBTB37

Gene Functionfor ZBTB37

Pathways & Interactionsfor ZBTB37

Drugs & Compoundsfor ZBTB37

Transcriptsfor ZBTB37

Expression for ZBTB37

Orthologsfor ZBTB37

Paralogsfor ZBTB37

SNPs/Variantsfor ZBTB37

Disorders & Mutationsfor ZBTB37

Medical Newsfor ZBTB37

Publicationsfor ZBTB37

Search for ZBTB37

Genome Databases showing ZBTB37

Other Databases showing ZBTB37

Specialized Databases showing ZBTB37

Licensable Technologiesfor ZBTB37

Servicesfor ZBTB37

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB37

Summaries
for ZBTB37

Genomic Location
for ZBTB37

Proteins
for ZBTB37

Protein Domains/
Families
for ZBTB37

Gene Function
for ZBTB37

Pathways & Interactions
for ZBTB37

Drugs & Compounds
for ZBTB37

Transcripts
for ZBTB37

Expression
for ZBTB37

Orthologs
for ZBTB37

Paralogs
for ZBTB37

SNPs/Variants
for ZBTB37

Disorders & Mutations
for ZBTB37

Medical News
for ZBTB37

Publications
for ZBTB37

Licensable Technologies
for ZBTB37

Services
for ZBTB37