ZBTB37 Gene
protein-coding GIFtS: 47
GCID: GC01P173837
|
|
zinc finger and BTB domain containing 37
| |
Aliases
for ZBTB37 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 371 2 | | ZNF9081 2 | | MGC26291 | | D430004I08Rik2 | | Zinc Finger And BTB Domain-Containing Protein 372 |
Export aliases for ZBTB37 gene to outside databasesPrevious GC identifers: GC01P170569 GC01P172103 GC01P145062 |
Summaries
for ZBTB37 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79Function: May be involved in transcriptional regulation
|
Genomic Views
for ZBTB37 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB37 gene promoter:
Elk-1 AML1a CUTL1 IRF-1 NF-kappaB Evi-1 CREB Ik-2 deltaCREB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB37
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB37 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25.1 Ensembl cytogenetic band: 1q25.1 HGNC cytogenetic band: 1q24.2ZBTB37 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P173837: view genomic region
(about GC identifiers)
Start:
|
173,837,220 bp from pter |
End:
|
173,866,494 bp from pter |
Size:
|
29,275 bases |
Orientation:
|
plus strand |
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Proteins
for ZBTB37 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 37 Size: 503 amino acids; 56055 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q5TC80 Q96M87 Q9BQ88Alternative splicing: 3 isoforms: Q5TC79-1 Q5TC79-2 Q5TC79-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZBTB37: NX_Q5TC79
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TC79
ZBTB37 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001116242.1 NP_115911.1
ENSEMBL proteins: ENSP00000356677 ENSP00000435062 ENSP00000356675 ENSP00000356674 ENSP00000415293 ENSP00000409408
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZBTB37 for ontologies About GeneDecksing
ZBTB37 Antibody Products:
Assay Products for ZBTB37: |
Protein
Domains /
Families
for ZBTB37 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB37 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5TC79ProtoNet protein and cluster: Q5TC79 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 3 C2H2-type zinc fingers |
Function
for ZBTB37 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB37 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB37 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB37 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZBTB37 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZBTB37:
|
Pathways & Interactions
for ZBTB37 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB37
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZBTB37 (Q5TC793 ENSP000003566744) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB37 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB37 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB37
Search CenterWatch for drugs/clinical trials and news about ZBTB37 / ZBT37
|
Transcripts
for ZBTB37 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB37 gene (2 alternative transcripts): NM_001122770.1 NM_032522.3 Unigene Cluster for ZBTB37: Zinc finger and BTB domain containing 37 Hs.668497 [show with all ESTs]Unigene Representative Sequence: AK0573106 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367704(uc001gjp.1) ENST00000490000 ENST00000367702 ENST00000367701
ENST00000427304(uc009wwp.1 uc001gjr.2) ENST00000432989(uc001gjq.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB37 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB37 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZBTB37 (NM_032522) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB37 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB37 |
Additional cDNA sequence: AF318371.1 AK057310.1 AK302696.1 BC003116.1 BC006315.2 4 DOTS entries: DT.75149991 DT.40212237 DT.101975545 DT.95154505 21 AceView cDNA sequences: AW237081 BF222713 AW204948 BC006315 BC003116 AA833546 NM_032522 AW136373 BX279840 AI954694 AF318371 AW590509 BI850982 AW139260 BF057788 AK057310 BF310280 BE262601 BI459864 CD708955 AV754688
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB37 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
|---|
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| SP1: | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZBTB37
|
Expression
for ZBTB37 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTTTTGTG
About this image
See ZBTB37 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB37
SOURCE GeneReport for Unigene cluster: Hs.668497
SABiosciences Custom PCR Arrays for ZBTB37
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB37
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB37 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB37 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB37 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB37 |
Orthologs
for ZBTB37 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB37 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZBTB371 |
zinc finger and BTB domain containing 37 |
81.11(n)
93.24(a) |
|
429073 XM_426629.2 XP_426629.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ZBTB376 |
-- |
89(a) |
1 ↔ 1 |
4(71400332-71409206) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC536392 |
hypothetical protein MGC53639 |
72.84(n) |
|
BC044333.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.161622 |
Transcribed sequence with moderate similarity to protein more |
74.45(n) |
|
BG799142.1 |
ENSEMBL Gene Tree for ZBTB37 (if available)
TreeFam Gene Tree for ZBTB37 (if available) |
Paralogs
for ZBTB37 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB37 gene
- ZBTB222 ZBTB342 NACC12 ZBTB62 ZBTB452 ZBTB92 NACC22 ZBTB432
- ZBTB262 ZBTB122 ZBTB202
18/22 SIMAP similar genes for ZBTB37 using alignment to 1 protein entry: ZBT37_HUMAN(see all similar genes):pp9003 DKFZp434J0650 kr-znf3 ZBTB34 HZF16 KLHL32
ZNF55 ZNF78L1 ZNF A-328A3.4 ZNF72 ZFS-5
ZNF697 ZNF844 PLZF ZNF808 ZFS-2 DKFZp686N0199
ZBTB37 for paralogs About GeneDecksing
|
Genomic Variants
for ZBTB37 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB37 (173837220 - 173866494 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZBTB37
1 CNV: 3320 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB37 |
|
Disorders
/ Diseases
for ZBTB37 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBTB37 for disorders About GeneDecksing
2  diseases for ZBTB37: About MalaCardspancreatic cancer pancreatitis
Human Genome Epidemiology (HuGE) Navigator: ZBTB37 (1 document)
Export disorders for ZBTB37 gene to outside databases
|
Publications
for ZBTB37 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB37 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZBTB37) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for ZBTB37 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB37 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB37 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB37 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB37 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB37 gene:
Search GeneIP for patents involving ZBTB37
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB37 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB37 |
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