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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB37 Gene

protein-coding   GIFtS: 46
GCID: GC01P173837

Zinc Finger And BTB Domain Containing 37

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 371 2
D430004I08Rik2
ZNF9082
Zinc Finger And BTB Domain-Containing Protein 372

External Ids:    HGNC: 283651   Entrez Gene: 846142   Ensembl: ENSG000001852787   UniProtKB: Q5TC793   

Export aliases for ZBTB37 gene to outside databases

Previous GC identifers: GC01P170569 GC01P172103 GC01P145062


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZBTB37 Gene: 
ZBTB37 (zinc finger and BTB domain containing 37) is a protein-coding gene. Diseases associated with ZBTB37 include pancreatic cancer, and pancreatitis. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZBTB34.

UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB37 gene promoter:
         Elk-1   AML1a   CUTL1   IRF-1   NF-kappaB   Evi-1   CREB   Ik-2   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB37 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q24.2

ZBTB37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB37 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P173837:  view genomic region     (about GC identifiers)

Start:
173,837,220 bp from pter      End:
173,866,494 bp from pter
Size:
29,275 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 37  
Size: 503 amino acids; 56055 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q5TC80 Q96M87 Q9BQ88
Alternative splicing: 3 isoforms:  Q5TC79-1   Q5TC79-2   Q5TC79-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZBTB37: NX_Q5TC79

Explore proteomics data for ZBTB37 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TC79

  • ZBTB37 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBTB37 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116242.1  NP_115911.1  

    ENSEMBL proteins: 
     ENSP00000356677   ENSP00000435062   ENSP00000356675   ENSP00000356674   ENSP00000415293  
     ENSP00000409408  

    Human Recombinant Protein Products for ZBTB37: 
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    Cloud-Clone Corp. Proteins for ZBTB37 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZBTB37 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q5TC79

    ProtoNet protein and cluster: Q5TC79

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT37_HUMAN, Q5TC79
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 3 C2H2-type zinc fingers


    ZBTB37 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT37_HUMAN, Q5TC79
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZBTB37 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB37:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBTB37 
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB37 (see all 16):
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB37


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB37

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZBTB37 (Q5TC793 ENSP000003566744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3BP4Q9P0V33, ENSP000003402374I2D: score=1 STRING: ENSP00000340237
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZBTB37 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB37 (ZBT37)

    Search CenterWatch for drugs/clinical trials and news about ZBTB37 / ZBT37

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZBTB37 gene (2 alternative transcripts): 
    NM_001122770.1  NM_032522.3  

    Unigene Cluster for ZBTB37:

    Zinc finger and BTB domain containing 37
    Hs.668497  [show with all ESTs]
    Unigene Representative Sequence: AK057310
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367704(uc001gjp.1) ENST00000490000 ENST00000367702 ENST00000367701
    ENST00000427304(uc009wwp.1 uc001gjr.2) ENST00000432989(uc001gjq.4)

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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB37 (see all 16):
    hsa-miR-124* hsa-miR-142-5p hsa-miR-495 hsa-miR-125a-5p hsa-miR-340 hsa-miR-183* hsa-miR-125b hsa-miR-7-1*
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB37
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB37

    Additional mRNA sequence: 

    AF318371.1 AK057310.1 AK302696.1 BC003116.1 BC006315.2 

    4 DOTS entries:

    DT.75149991  DT.40212237  DT.101975545  DT.95154505 

    21 AceView cDNA sequences:

    NM_032522 AW204948 BC006315 BC003116 AA833546 AW237081 BF222713 BF057788 
    BX279840 AI954694 AW136373 AF318371 BI850982 AW139260 AW590509 AK057310 
    BF310280 BE262601 BI459864 CD708955 AV754688 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB37    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
    SP1:        -     -                                 
    SP2:              -                                 
    SP3:                                                
    SP4:                                                


    ECgene alternative splicing isoforms for ZBTB37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTTTGTG
    ZBTB37 Expression
    About this image


    See ZBTB37 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB37

    SOURCE GeneReport for Unigene cluster: Hs.668497
        SABiosciences Custom PCR Arrays for ZBTB37
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB37 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb371 , 5 zinc finger and BTB domain containing 371, 5 91.3(n)1
    95.22(a)1
      1 (69.75 cM)5
    2408691  NM_173424.31  NP_775600.11 
     1610087945 
    chicken
    (Gallus gallus)
    Aves ZBTB371 zinc finger and BTB domain containing 37 81.11(n)
    93.24(a)
      429073  XM_426629.2  XP_426629.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB376
    Uncharacterized protein
    89(a)
    1 ↔ 1
    4(71400332-71409206)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC536392 hypothetical protein MGC53639 72.84(n)    BC044333.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.161622 Transcribed sequence with moderate similarity to protein more 74.45(n)    BG799142.1 


    ENSEMBL Gene Tree for ZBTB37 (if available)
    TreeFam Gene Tree for ZBTB37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB37 gene
    ZBTB342  ZBTB222  NACC12  ZBTB452  ZBTB62  ZBTB92  NACC22  ZBTB262  
    ZBTB432  ZBTB122  ZBTB202  
    18/21 SIMAP similar genes for ZBTB37 using alignment to 1 protein entry:     ZBT37_HUMAN(see all similar genes):
    pp9003    DKFZp434J0650    kr-znf3    ZBTB34    HZF16    KLHL32
    ZNF55    ZNF78L1    ZNF    A-328A3.4    ZNF72    ZFS-5
    ZNF697    ZNF844    PLZF    ZNF808    ZFS-2    DKFZp686N0199

    ZBTB37 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/333 SNPs in ZBTB37 are shown (see all 333)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs13227741,2
    C,F,O,A,H--173839240(+) TGAAAC/TTTTAC 2 -- int117Minor allele frequency- T:0.37NA EA NS WA CSA 1151
    rs168464951,2
    C,F,H--173839286(+) CCATCC/TGGGAA 2 -- int110Minor allele frequency- T:0.01NA NS 994
    rs1497381471,2
    C--173839387(+) ATACAA/GTTGGA 4 Q syn10--------
    rs94257611,2
    C,F,H--173839435(+) AACCAG/ATTGCG 4 /Q syn124Minor allele frequency- A:0.13NS EA NA WA CSA EU 7873
    rs1995335671,2
    --173839443(+) GCGCAC/TGCAGG 4 T M mis10--------
    rs1447996871,2
    C,F--173839540(+) CGGGAT/CCACAT 4 /D syn12Minor allele frequency- C:0.00NA EU 5875
    rs2003021891,2
    C--173839690(+) TTTCTG/ACAAAT 4 /L syn11Minor allele frequency- A:0.00EU 1299
    rs1394611941,2
    C,F--173839830(+) GGTTAC/GACCAA 4 T R mis11Minor allele frequency- G:0.00NA 4548
    rs2018276941,2
    --173839863(+) ACGACA/GTAATA 4 H R mis10--------
    rs2015447991,2
    C--173839884(+) AAACCA/GGCGAG 4 Q R mis10--------

    HapMap Linkage Disequilibrium report for ZBTB37 (173837220 - 173866494 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZBTB37:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831926CNV Gain+Loss17160897
    dgv149e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZBTB37:    About MalaCards
    pancreatic cancer    pancreatitis


    ZBTB37 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZBTB37
    Human Genome Epidemiology (HuGE) Navigator: ZBTB37 (1 document)

    Export disorders for ZBTB37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB37 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZBTB37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (2008)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84614 HGNC: 28365 AceView: ZBTB37 Ensembl:ENSG00000185278 euGenes: HUgn84614
    ECgene: ZBTB37 H-InvDB: ZBTB37

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB37 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZBTB37 gene:
    Search GeneIP for patents involving ZBTB37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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