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Aliases for ZBTB34 Gene

Aliases for ZBTB34 Gene

  • Zinc Finger And BTB Domain Containing 34 2 3
  • KIAA1993 4 6
  • Zinc Finger And BTB Domain-Containing Protein 34 3
  • ZNF918 3

External Ids for ZBTB34 Gene

Summaries for ZBTB34 Gene

GeneCards Summary for ZBTB34 Gene

ZBTB34 (Zinc Finger And BTB Domain Containing 34) is a Protein Coding gene. An important paralog of this gene is NACC2.

UniProtKB/Swiss-Prot for ZBTB34 Gene

  • May be a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB34 Gene

Genomics for ZBTB34 Gene

Genomic Location for ZBTB34 Gene

Start:
126,860,665 bp from pter
End:
126,885,878 bp from pter
Size:
25,214 bases
Orientation:
Plus strand

Genomic View for ZBTB34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB34 Gene

Regulatory Elements for ZBTB34 Gene

Proteins for ZBTB34 Gene

  • Protein details for ZBTB34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCN2-ZBT34_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 34
    Protein Accession:
    Q8NCN2
    Secondary Accessions:
    • Q38IA7
    • Q5VYE9

    Protein attributes for ZBTB34 Gene

    Size:
    500 amino acids
    Molecular mass:
    55534 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=ABA86591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC02702.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH69994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZBTB34 Gene

Proteomics data for ZBTB34 Gene at MOPED

Post-translational modifications for ZBTB34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB34 Gene

Domains for ZBTB34 Gene

Gene Families for ZBTB34 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

Protein Domains for ZBTB34 Gene

UniProtKB/Swiss-Prot:

ZBT34_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q8NCN2
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q8NCN2
genes like me logo Genes that share domains with ZBTB34: view

Function for ZBTB34 Gene

Molecular function for ZBTB34 Gene

UniProtKB/Swiss-Prot Function: May be a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB34: view

Phenotypes for ZBTB34 Gene

GenomeRNAi human phenotypes for ZBTB34:
genes like me logo Genes that share phenotypes with ZBTB34: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB34 Gene

Localization for ZBTB34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB34 Gene COMPARTMENTS Subcellular localization image for ZBTB34 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB34: view

Pathways for ZBTB34 Gene

SuperPathways for ZBTB34 Gene

No Data Available

Interacting Proteins for ZBTB34 Gene

Gene Ontology (GO) - Biological Process for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB34: view

No data available for Pathways by source for ZBTB34 Gene

Transcripts for ZBTB34 Gene

mRNA/cDNA for ZBTB34 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB34 Gene

Zinc finger and BTB domain containing 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB34 Gene

No ASD Table

Relevant External Links for ZBTB34 Gene

GeneLoc Exon Structure for
ZBTB34
ECgene alternative splicing isoforms for
ZBTB34

Expression for ZBTB34 Gene

mRNA expression in normal human tissues for ZBTB34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB34 Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB34 Gene

SOURCE GeneReport for Unigene cluster for ZBTB34 Gene Hs.177633

mRNA Expression by UniProt/SwissProt for ZBTB34 Gene

Q8NCN2-ZBT34_HUMAN
Tissue specificity: Expressed in several tissues, including heart, brain, thymus, skeletal muscle, small intestine, testis, kidney, placenta, peripheral blood cells and adult and fetal liver.
genes like me logo Genes that share expressions with ZBTB34: view

Orthologs for ZBTB34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB34 36
  • 99.73 (n)
  • 100 (a)
ZBTB34 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB34 36
  • 90.13 (n)
  • 97.2 (a)
ZBTB34 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB34 36
  • 92.6 (n)
  • 98.8 (a)
ZBTB34 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb34 36
  • 88.07 (n)
  • 93.2 (a)
Zbtb34 16
Zbtb34 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB34 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB34 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb34 36
  • 87.87 (n)
  • 93.2 (a)
chicken
(Gallus gallus)
Aves ZBTB34 36
  • 79.43 (n)
  • 88.98 (a)
ZBTB34 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB34 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb34 36
  • 73.2 (n)
  • 80 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100004439 36
  • 66.67 (n)
  • 69.28 (a)
zbtb34 37
  • 60 (a)
OneToOne
Species with no ortholog for ZBTB34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB34 Gene

ENSEMBL:
Gene Tree for ZBTB34 (if available)
TreeFam:
Gene Tree for ZBTB34 (if available)

Paralogs for ZBTB34 Gene

genes like me logo Genes that share paralogs with ZBTB34: view

Variants for ZBTB34 Gene

Sequence variations from dbSNP and Humsavar for ZBTB34 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12178 -- 126,884,496(+) TTTTT(A/G)AACAG utr-variant-3-prime
rs571606 -- 126,884,749(-) GATTT(C/T)CCCCC utr-variant-3-prime
rs624903 -- 126,884,943(-) CAAGG(A/G)GCATG utr-variant-3-prime
rs1566210 -- 126,869,571(+) CACAG(C/T)AGCCC intron-variant
rs1976329 -- 126,872,098(-) atggt(A/G)gcagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB34 Gene

Variant ID Type Subtype PubMed ID
nsv893849 CNV Gain 21882294
nsv831724 CNV Gain 17160897
nsv831726 CNV Gain+Loss 17160897
nsv6719 CNV Insertion 18451855
nsv825086 CNV Gain 20364138
esv989100 CNV Insertion 20482838
esv2465457 CNV Insertion 19546169

Relevant External Links for ZBTB34 Gene

HapMap Linkage Disequilibrium report
ZBTB34

Disorders for ZBTB34 Gene

No disorders were found for ZBTB34 Gene.

No data available for UniProtKB/Swiss-Prot for ZBTB34 Gene

Publications for ZBTB34 Gene

  1. ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor. (PMID: 16718364) Qi J. … Han Z.-G. (Mol. Cell. Biochem. 2006) 2 3 4
  2. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PMID: 12056414) Ohara O. … Koseki H. (DNA Res. 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ZBTB34 Gene

Sources for ZBTB34 Gene

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