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Aliases for ZBTB34 Gene

Aliases for ZBTB34 Gene

  • Zinc Finger And BTB Domain Containing 34 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 34 3
  • KIAA1993 4
  • ZNF918 3

External Ids for ZBTB34 Gene

Previous GeneCards Identifiers for ZBTB34 Gene

  • GC09U900570
  • GC09P126703
  • GC09P128662
  • GC09P129622
  • GC09P099236

Summaries for ZBTB34 Gene

GeneCards Summary for ZBTB34 Gene

ZBTB34 (Zinc Finger And BTB Domain Containing 34) is a Protein Coding gene. An important paralog of this gene is ZBTB37.

UniProtKB/Swiss-Prot for ZBTB34 Gene

  • May be a transcriptional repressor.

Additional gene information for ZBTB34 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB34 Gene

Genomics for ZBTB34 Gene

Regulatory Elements for ZBTB34 Gene

Enhancers for ZBTB34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H125883 2.1 VISTA 11.5 -976.7 -976665 1 PKNOX1 ARNT FEZF1 ZSCAN5C ZNF350 ZNF174 OVOL3 CEBPB ZNF488 ZNF843 GAPVD1 PBX3 ZBTB34 PRPS1P2 GC09P125878 GC09P125901
GH09H127553 2 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +704.3 704283 23 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 FOS FAM129B ENG ZBTB34 SNORA65 CIZ1 FPGS RPL12 TOR2A LOC102723566 SLC2A8
GH09H125909 1.8 VISTA 12.3 -950.5 -950511 1 PKNOX1 MXI1 ARNT ZNF266 FEZF1 CTBP1 POLR2A ZNF366 ZSCAN5C ZEB2 GOLGA1 GAPVD1 PRPS1P2 ZBTB34 GC09P125902 LOC105376273
GH09H126790 1.5 Ensembl ENCODE dbSUPER 11 -67.9 -67877 4 PKNOX1 FEZF1 BRCA1 ZNF121 KLF7 FOS DEK TSHZ1 REST MAFF ZBTB34 ENSG00000252985 ZBTB43 LRSAM1 PIR57638
GH09H126804 1.4 ENCODE dbSUPER 11.2 -54.9 -54946 3 HDGF PKNOX1 ARID4B SIN3A YBX1 YY1 SLC30A9 CBX5 ZNF143 FOS ZNF79 ZBTB34 RALGPS1 ZBTB43
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB34 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241604 435 2201 HDGF ARID4B SIN3A DMAP1 ZNF2 ZBTB7B GLIS2 ZNF302 ELK1 ZNF207

Genomic Location for ZBTB34 Gene

Chromosome:
9
Start:
126,860,665 bp from pter
End:
126,885,878 bp from pter
Size:
25,214 bases
Orientation:
Plus strand

Genomic View for ZBTB34 Gene

Genes around ZBTB34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB34 Gene

Proteins for ZBTB34 Gene

  • Protein details for ZBTB34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCN2-ZBT34_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 34
    Protein Accession:
    Q8NCN2
    Secondary Accessions:
    • Q38IA7
    • Q5VYE9

    Protein attributes for ZBTB34 Gene

    Size:
    500 amino acids
    Molecular mass:
    55534 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=ABA86591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC02702.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH69994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZBTB34 Gene

Post-translational modifications for ZBTB34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB34 Gene

No data available for DME Specific Peptides for ZBTB34 Gene

Domains & Families for ZBTB34 Gene

Gene Families for ZBTB34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB34 Gene

Suggested Antigen Peptide Sequences for ZBTB34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB34: view

No data available for UniProtKB/Swiss-Prot for ZBTB34 Gene

Function for ZBTB34 Gene

Molecular function for ZBTB34 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB34: view
genes like me logo Genes that share phenotypes with ZBTB34: view

Animal Model Products

CRISPR Products

miRNA for ZBTB34 Gene

miRTarBase miRNAs that target ZBTB34

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZBTB34
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB34 Gene

Localization for ZBTB34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB34 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB34: view

Pathways & Interactions for ZBTB34 Gene

SuperPathways for ZBTB34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB34: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB34 Gene

Drugs & Compounds for ZBTB34 Gene

No Compound Related Data Available

Transcripts for ZBTB34 Gene

mRNA/cDNA for ZBTB34 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB34 Gene

Zinc finger and BTB domain containing 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZBTB34
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB34 Gene

No ASD Table

Relevant External Links for ZBTB34 Gene

GeneLoc Exon Structure for
ZBTB34
ECgene alternative splicing isoforms for
ZBTB34

Expression for ZBTB34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB34 Gene

This gene is overexpressed in Whole Blood (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB34 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZBTB34 Gene:

ZBTB34

SOURCE GeneReport for Unigene cluster for ZBTB34 Gene:

Hs.177633

mRNA Expression by UniProt/SwissProt for ZBTB34 Gene:

Q8NCN2-ZBT34_HUMAN
Tissue specificity: Expressed in several tissues, including heart, brain, thymus, skeletal muscle, small intestine, testis, kidney, placenta, peripheral blood cells and adult and fetal liver.

Evidence on tissue expression from TISSUES for ZBTB34 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZBTB34: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB34 Gene

Orthologs for ZBTB34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB34 33 34
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia ZBTB34 33 34
  • 92.6 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB34 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB34 33 34
  • 90.13 (n)
mouse
(Mus musculus)
Mammalia Zbtb34 33 16 34
  • 88.07 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb34 33
  • 87.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB34 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB34 33 34
  • 79.43 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB34 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb34 33
  • 73.2 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100004439 33
  • 66.67 (n)
zbtb34 34
  • 60 (a)
OneToOne
Species where no ortholog for ZBTB34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB34 Gene

ENSEMBL:
Gene Tree for ZBTB34 (if available)
TreeFam:
Gene Tree for ZBTB34 (if available)

Paralogs for ZBTB34 Gene

genes like me logo Genes that share paralogs with ZBTB34: view

Variants for ZBTB34 Gene

Sequence variations from dbSNP and Humsavar for ZBTB34 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000000472 -- 126,872,591(+) TCTGA(-/CCT)CCTCT intron-variant
rs1000004702 -- 126,878,222(+) CCCAG(A/G)ACTTT intron-variant
rs1000096914 -- 126,872,908(+) GTTCC(A/G)TTTTT intron-variant
rs1000149392 -- 126,872,596(+) CCTCC(G/T)CTATC intron-variant
rs1000354866 -- 126,866,953(+) AAACG(C/T)ACATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB34 Gene

Variant ID Type Subtype PubMed ID
esv2465457 CNV insertion 19546169
esv3415514 CNV duplication 20981092
esv3573390 CNV loss 25503493
esv3621766 CNV gain 21293372
esv989100 CNV insertion 20482838
nsv1075673 CNV deletion 25765185
nsv6719 CNV insertion 18451855
nsv825086 CNV gain 20364138
nsv831724 CNV gain 17160897
nsv831726 CNV gain+loss 17160897

Variation tolerance for ZBTB34 Gene

Residual Variation Intolerance Score: 7.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB34 Gene

Disorders for ZBTB34 Gene

Relevant External Links for ZBTB34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB34

No disorders were found for ZBTB34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB34 Gene

Publications for ZBTB34 Gene

  1. ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor. (PMID: 16718364) Qi J … Han ZG (Molecular and cellular biochemistry 2006) 2 3 4 60
  2. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PMID: 12056414) Ohara O … Koseki H (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 60
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 60

Products for ZBTB34 Gene

Sources for ZBTB34 Gene

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