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Aliases for ZBTB34 Gene

Aliases for ZBTB34 Gene

  • Zinc Finger And BTB Domain Containing 34 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 34 3
  • KIAA1993 4
  • ZNF918 3

External Ids for ZBTB34 Gene

Previous GeneCards Identifiers for ZBTB34 Gene

  • GC09U900570
  • GC09P126703
  • GC09P128662
  • GC09P129622
  • GC09P099236

Summaries for ZBTB34 Gene

GeneCards Summary for ZBTB34 Gene

ZBTB34 (Zinc Finger And BTB Domain Containing 34) is a Protein Coding gene. An important paralog of this gene is ZBTB37.

UniProtKB/Swiss-Prot for ZBTB34 Gene

  • May be a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB34 Gene

Genomics for ZBTB34 Gene

Regulatory Elements for ZBTB34 Gene

Enhancers for ZBTB34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZBTB34 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZBTB34 Gene

Chromosome:
9
Start:
126,860,665 bp from pter
End:
126,885,878 bp from pter
Size:
25,214 bases
Orientation:
Plus strand

Genomic View for ZBTB34 Gene

Genes around ZBTB34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB34 Gene

Proteins for ZBTB34 Gene

  • Protein details for ZBTB34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCN2-ZBT34_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 34
    Protein Accession:
    Q8NCN2
    Secondary Accessions:
    • Q38IA7
    • Q5VYE9

    Protein attributes for ZBTB34 Gene

    Size:
    500 amino acids
    Molecular mass:
    55534 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=ABA86591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC02702.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH69994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZBTB34 Gene

Post-translational modifications for ZBTB34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB34 Gene

Domains & Families for ZBTB34 Gene

Gene Families for ZBTB34 Gene

Protein Domains for ZBTB34 Gene

Suggested Antigen Peptide Sequences for ZBTB34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NCN2

UniProtKB/Swiss-Prot:

ZBT34_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 3 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB34: view

Function for ZBTB34 Gene

Molecular function for ZBTB34 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB34: view
genes like me logo Genes that share phenotypes with ZBTB34: view

Animal Model Products

CRISPR Products

miRNA for ZBTB34 Gene

miRTarBase miRNAs that target ZBTB34

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB34 Gene

Localization for ZBTB34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB34 Gene COMPARTMENTS Subcellular localization image for ZBTB34 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB34: view

Pathways & Interactions for ZBTB34 Gene

SuperPathways for ZBTB34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB34: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB34 Gene

Drugs & Compounds for ZBTB34 Gene

No Compound Related Data Available

Transcripts for ZBTB34 Gene

mRNA/cDNA for ZBTB34 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB34 Gene

Zinc finger and BTB domain containing 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB34 Gene

No ASD Table

Relevant External Links for ZBTB34 Gene

GeneLoc Exon Structure for
ZBTB34
ECgene alternative splicing isoforms for
ZBTB34

Expression for ZBTB34 Gene

mRNA expression in normal human tissues for ZBTB34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB34 Gene

This gene is overexpressed in Whole Blood (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB34 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZBTB34 Gene:

ZBTB34

SOURCE GeneReport for Unigene cluster for ZBTB34 Gene:

Hs.177633

mRNA Expression by UniProt/SwissProt for ZBTB34 Gene:

Q8NCN2-ZBT34_HUMAN
Tissue specificity: Expressed in several tissues, including heart, brain, thymus, skeletal muscle, small intestine, testis, kidney, placenta, peripheral blood cells and adult and fetal liver.
genes like me logo Genes that share expression patterns with ZBTB34: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for ZBTB34 Gene

Orthologs for ZBTB34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB34 35
  • 99 (a)
OneToOne
ZBTB34 34
  • 99.73 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB34 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb34 35
  • 90 (a)
OneToOne
Zbtb34 16
Zbtb34 34
  • 88.07 (n)
  • 93.2 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBTB34 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB34 35
  • 95 (a)
OneToOne
ZBTB34 34
  • 92.6 (n)
  • 98.8 (a)
cow
(Bos Taurus)
Mammalia ZBTB34 35
  • 95 (a)
OneToOne
ZBTB34 34
  • 90.13 (n)
  • 97.2 (a)
rat
(Rattus norvegicus)
Mammalia Zbtb34 34
  • 87.87 (n)
  • 93.2 (a)
chicken
(Gallus gallus)
Aves ZBTB34 35
  • 89 (a)
OneToOne
ZBTB34 34
  • 79.43 (n)
  • 88.98 (a)
lizard
(Anolis carolinensis)
Reptilia ZBTB34 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb34 34
  • 73.2 (n)
  • 80 (a)
zebrafish
(Danio rerio)
Actinopterygii zbtb34 35
  • 60 (a)
OneToOne
LOC100004439 34
  • 66.67 (n)
  • 69.28 (a)
Species where no ortholog for ZBTB34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB34 Gene

ENSEMBL:
Gene Tree for ZBTB34 (if available)
TreeFam:
Gene Tree for ZBTB34 (if available)

Paralogs for ZBTB34 Gene

genes like me logo Genes that share paralogs with ZBTB34: view

Variants for ZBTB34 Gene

Sequence variations from dbSNP and Humsavar for ZBTB34 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs12178 -- 126,884,496(+) TTTTT(A/G)AACAG utr-variant-3-prime
rs571606 -- 126,884,749(-) GATTT(C/T)CCCCC utr-variant-3-prime
rs624903 -- 126,884,943(-) CAAGG(A/G)GCATG utr-variant-3-prime
rs117054670 -- 126,866,951(+) CAAAA(C/T)GTACA intron-variant
rs10121685 -- 126,869,302(+) AGATA(C/T)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB34 Gene

Variant ID Type Subtype PubMed ID
esv2465457 CNV insertion 19546169
esv3415514 CNV duplication 20981092
esv3573390 CNV loss 25503493
esv3621766 CNV gain 21293372
esv989100 CNV insertion 20482838
nsv1075673 CNV deletion 25765185
nsv6719 CNV insertion 18451855
nsv825086 CNV gain 20364138
nsv831724 CNV gain 17160897
nsv831726 CNV gain+loss 17160897

Variation tolerance for ZBTB34 Gene

Residual Variation Intolerance Score: 7.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB34 Gene

Disorders for ZBTB34 Gene

Relevant External Links for ZBTB34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB34

No disorders were found for ZBTB34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB34 Gene

Publications for ZBTB34 Gene

  1. ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor. (PMID: 16718364) Qi J. … Han Z.-G. (Mol. Cell. Biochem. 2006) 2 3 4 65
  2. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PMID: 12056414) Ohara O. … Koseki H. (DNA Res. 2002) 3 4 65
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 65
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 65

Products for ZBTB34 Gene

Sources for ZBTB34 Gene

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