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ZBTB34 Gene

protein-coding GIFtS: 41

GC09P128662

zinc finger and BTB domain containing 34
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ22470 ^²
KIAA1993 ^¹, ², ³, ⁵
MGC24652 ^¹, ²
RP11-106H5.1 ^²

Descriptions
zinc finger and BTB domain containing 34 ^²

External Ids
HGNC: 31446¹
Entrez Gene: 403341²
UniProtKB: Q8NCN2³
Ensembl: ENSG00000177125⁷

Search outside databases for aliases for ZBTB34 gene

Previous GC identifers: GC09U900570 GC09P126703

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ZBT34_HUMAN, Q8NCN2

Function: May be a transcriptional repressor

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZBTB34 gene

Entrez Gene cytogenetic band: 9q33.3 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q33.3

ZBTB34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P128662: (about GC identifiers)

Start:	128,662,765 bp from pter
End:	128,687,978 bp from pter
Size:	25,214 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBT34_HUMAN, Q8NCN2 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 34

Size: 504 amino acids; 55981 Da

Subcellular location: Nucleus

Secondary accessions: Q38IA7 Q5VYE9

REFSEQ proteins: NP_001092740.1

ENSEMBL proteins:

ENSP00000317534 ENSP00000362551

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

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Antibodies for ZBTB34:

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	Sigma-Aldrich Antibodies for ZBTB34
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Assays for ZBTB34:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8NCN2

ProtoNet protein and cluster: Q8NCN2

UniProtKB/Swiss-Prot: ZBT34_HUMAN, Q8NCN2

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 3 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Applied Biosystems Silencer® siRNAs for ZBTB34

Sigma-Aldrich siRNA and siRNA Panels for ZBTB34

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZBTB34
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001099270
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001099270
untagged cDNA clone in CMV expression vector: NM_001099270

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001099270

UniProtKB/Swiss-Prot: ZBT34_HUMAN, Q8NCN2

Function: May be a transcriptional repressor

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB34

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Sigma-Aldrich siRNA and siRNA Panels for ZBTB34

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001099270

REFSEQ mRNAs for ZBTB34 gene:

NM_001099270.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001099270

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001099270
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001099270
                                 untagged cDNA clone in CMV expression vector: NM_001099270

Additional cDNA sequence:

AB082524.1 AK055661.1 AK074274.1 BC020929.1 BC035710.1 DQ227306.1

1 DOTS entry:

DT.114997

highest scoring ESTs for ZBTB34:

AA211297 AA211298 AA292215 AA292220 AA399223 AA399362 AA704544 AA714664 AA730259 AA766220

Unigene Cluster for ZBTB34:

Zinc finger and BTB domain containing 34

Hs.177633 [show with all ESTs]

Unigene Representative Sequence: NM_001099270

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000319119 ENST00000373452

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ZBTB34 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB34

¹ / ² / ³

3 probe-sets matching ZBTB34 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54820_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA203581	0.40	1.00	0.76	1
227111_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BG179317	0.60	1.00	0.82	1
227111_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATATTTCAG

SOURCE GeneReport for Unigene cluster: Hs.177633
UniProtKB/Swiss-Prot: ZBT34_HUMAN, Q8NCN2
Tissue specificity: Expressed in several tissues, including heart, brain, thymus, skeletal muscle,
small intestine, testis, kidney, placenta, peripheral blood cells and adult and fetal liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBTB34 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBTB34¹	--	zinc finger and BTB domain containing 34	92.6(n) 98.8(a)	491331 XM_548452.2 XP_548452.2
chimpanzee (Pan troglodytes)	ZBTB34¹	--	zinc finger and BTB domain containing 34	99.73(n) 100(a)	740152 XM_001142000.1 XP_001142000.1
cow (Bos taurus)	ZBTB34¹	--	zinc finger and BTB domain containing 34	90.13(n) 97.2(a)	518084 XM_596267.2 XP_596267.2
rat (Rattus norvegicus)	Zbtb34¹	--	zinc finger and BTB domain containing 34	87.87(n) 93.2(a)	689174 XM_001069858.1 XP_001069858.1
mouse (Mus musculus)	Zbtb34^{1, 5}	2⁵	zinc finger and BTB domain containing 34^{1, 5}	88.07(n)¹ 93.2(a)¹	241311¹ XM_140881.6¹ XP_140881.4¹ AK173321⁵ AL928955⁵ (see all 6)

About this table Species with no ortholog for ZBTB34

ENSEMBL Gene Tree for ZBTB34

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB34 gene

ZBTB22² ZBTB9² ZBTB43² ZBTB37²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/80 NCBI SNPs in ZBTB34 are shown (see all 80 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 39)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs571606^1,2	A,C,F,H,O	128686849(-)	`GATTTT/CCCCCC`	1	--	ut3¹ trp³		4		MN EU EA	482
	rs12178^1,2	A,C,F,H	128686596(+)	`TTTTTA/GAACAG`	1	--	ut3¹		16		MN EU EA WA NA	1578
	rs10819246^1,2	A,C,F,H	128683117(+)	`TCTTGG/TTCTCT`	1	--	ut3¹ ese³		8		EU EA WA	836
--	rs12235895^1,2	A,C,F,H	128688352(+)	`CAGGGA/GCCCCT`	1	--	ng3¹		8		EU EA WA	808
	rs624903^1,2	A,C,F,H	128687043(-)	`CAAGGG/AGCATG`	1	--	ut3¹ ese³		5		MN EU EA WA	602
	rs12002895^1,2	C	128685436(+)	`CCAGCA/GAGGTT`	1	--	ut3¹ ese³		0	--	--	--	--
	rs10819243^1,2	A,C,F,H	128673149(+)	`CCTGTG/AAACAG`	1	--	int¹		4		EU EA WA	418
	rs7030157^1,2	A,C,F,H	128665047(+)	`TTTTAT/CCAGCT`	1	--	int¹		4		EU EA WA	414
	rs10819242^1,2	A,C,F,H	128669947(+)	`ATCCTC/TCATAC`	1	--	int¹		4		EU EA WA	416
	rs10760462^1,2	C,F,H	128667739(+)	`TTGTTT/GCATTT`	1	--	int¹		8		EU EA WA	838

About this table

HapMap Linkage Disequilibrium images for ZBTB34 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611692

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for ZBTB34 gene:

ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor. (PubMed id 16718364)^{2, 3, 4} Qi J.... Han Z.-G. (2006)
Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)^{3, 4} Ohara O.... Koseki H. (2002)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)⁴ Humphray S.J.... Dunham I. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 403341	HGNC: 31446	Ensembl:ENSG00000177125	euGenes: HUgn403341	ECgene: ZBTB34
H-InvDB: ZBTB34

(According to HUGE)
About This Section

HUGE: KIAA1993

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZBTB34
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ZBTB34:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB34-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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ZBTB34 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for ZBTB34

Summaries
for ZBTB34

Genomic Location
for ZBTB34

Proteins
for ZBTB34

Protein Domains/
Families
for ZBTB34

Gene Function
for ZBTB34

Pathways & Interactions
for ZBTB34

Drugs & Compounds
for ZBTB34

Transcripts
for ZBTB34

Expression
for ZBTB34

Orthologs
for ZBTB34

Paralogs
for ZBTB34

SNPs/Variants
for ZBTB34

Disorders & Mutations
for ZBTB34

Medical News
for ZBTB34

Publications
for ZBTB34

Search for ZBTB34

Genome Databases showing ZBTB34

Other Databases showing ZBTB34

Specialized Databases showing ZBTB34

Licensable Technologies
for ZBTB34

Services
for ZBTB34

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB34 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor ZBTB34

Summariesfor ZBTB34

Genomic Locationfor ZBTB34

Proteinsfor ZBTB34

Protein Domains/Familiesfor ZBTB34

Gene Functionfor ZBTB34

Pathways & Interactionsfor ZBTB34

Drugs & Compoundsfor ZBTB34

Transcriptsfor ZBTB34

Expression for ZBTB34

Orthologsfor ZBTB34

Paralogsfor ZBTB34

SNPs/Variantsfor ZBTB34

Disorders & Mutationsfor ZBTB34

Medical Newsfor ZBTB34

Publicationsfor ZBTB34

Search for ZBTB34

Genome Databases showing ZBTB34

Other Databases showing ZBTB34

Specialized Databases showing ZBTB34

Licensable Technologiesfor ZBTB34

Servicesfor ZBTB34

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB34

Summaries
for ZBTB34

Genomic Location
for ZBTB34

Proteins
for ZBTB34

Protein Domains/
Families
for ZBTB34

Gene Function
for ZBTB34

Pathways & Interactions
for ZBTB34

Drugs & Compounds
for ZBTB34

Transcripts
for ZBTB34

Expression
for ZBTB34

Orthologs
for ZBTB34

Paralogs
for ZBTB34

SNPs/Variants
for ZBTB34

Disorders & Mutations
for ZBTB34

Medical News
for ZBTB34

Publications
for ZBTB34

Licensable Technologies
for ZBTB34

Services
for ZBTB34