ZBTB34 Gene
protein-coding GIFtS: 40
GCID: GC09P129622
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|
zinc finger and BTB domain containing 34
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Aliases
for ZBTB34 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 341 2 | | KIAA19931 3 5 | | ZNF9181 2 | | MGC246521 | | RP11-106H5.12 | | Zinc Finger And BTB Domain-Containing Protein 342 |
Export aliases for ZBTB34 gene to outside databasesPrevious GC identifers: GC09U900570 GC09P126703 GC09P128662 GC09P099236 |
Summaries
for ZBTB34 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT34_HUMAN, Q8NCN2Function: May be a transcriptional repressor
|
Genomic Views
for ZBTB34 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB34 gene promoter:
AML1a MyoD Tal-1beta E47 Nkx6-1 Hand1 Pax-4a MRF-2 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB34
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB34 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q33.3 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q33.3ZBTB34 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P129622: view genomic region
(about GC identifiers)
Start:
|
129,622,944 bp from pter |
End:
|
129,648,157 bp from pter |
Size:
|
25,214 bases |
Orientation:
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plus strand |
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Proteins
for ZBTB34 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT34_HUMAN, Q8NCN2 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 34 Size: 500 amino acids; 55534 Da
Subcellular location: Nucleus
Sequence caution: Sequence=ABA86591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAC02702.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAH69994.1;Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q38IA7 Q5VYE9Explore the universe of human proteins at neXtProt for ZBTB34: NX_Q8NCN2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCN2
ZBTB34 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001092740.1
ENSEMBL proteins: ENSP00000317534 ENSP00000362551
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZBTB34 for ontologies About GeneDecksing
ZBTB34 Antibody Products:
Assay Products for ZBTB34: |
Protein
Domains /
Families
for ZBTB34 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB34 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8NCN2ProtoNet protein and cluster: Q8NCN2 UniProtKB/Swiss-Prot: ZBT34_HUMAN, Q8NCN2Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 3 C2H2-type zinc fingers |
Function
for ZBTB34 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT34_HUMAN, Q8NCN2Function: May be a transcriptional repressor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB34 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB34
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZBTB34 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB34 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB34 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZBTB34 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZBTB34:
|
Pathways & Interactions
for ZBTB34 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB34
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB34 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB34 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB34
Search CenterWatch for drugs/clinical trials and news about ZBTB34 / ZBT34
|
Transcripts
for ZBTB34 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB34 gene (2 alternative transcripts): NM_203482.1 NM_001099270.1 Unigene Cluster for ZBTB34: Zinc finger and BTB domain containing 34 Hs.177633 [show with all ESTs]Unigene Representative Sequence: NM_0010992702 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000319119(uc004bqm.4) ENST00000373452(uc022bnn.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB34 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB34
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB34 (NM_001099270) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB34 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB34 |
Additional cDNA sequence: AB082524.1 AK055661.1 AK074274.1 BC020929.1 BC035710.1 DQ227306.1 1 DOTS entry: DT.114997
GeneLoc Exon Structure
|
Expression
for ZBTB34 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATATTTCAG
About this image
See ZBTB34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB34
SOURCE GeneReport for Unigene cluster: Hs.177633
UniProtKB/Swiss-Prot: ZBT34_HUMAN, Q8NCN2Tissue specificity: Expressed in several tissues, including heart, brain, thymus, skeletal muscle, small intestine,testis, kidney, placenta, peripheral blood cells and adult and fetal liver
SABiosciences Custom PCR Arrays for ZBTB34
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB34
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB34 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB34 |
Orthologs
for ZBTB34 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB34 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for ZBTB34 (if available)
TreeFam Gene Tree for ZBTB34 (if available) |
Paralogs
for ZBTB34 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB34 gene
- ZBTB222 NACC12 ZBTB62 ZBTB452 ZBTB92 NACC22 ZBTB432 ZBTB262
- ZBTB122 ZBTB372 ZBTB202
18/22 SIMAP similar genes for ZBTB34 using alignment to 1 protein entry: ZBT34_HUMAN(see all similar genes):DKFZp434J0650 kr-znf3 ZBTB37 ZNF78L1 DKFZp686M04222 ZFS-5
KLHL32 ZNF ZNF697 BACH2 ZNF72 DKFZp547H249
DKFZp686N0199 ZNF844 ZNF55 pp9003 ZFS-2 ZFS-6
ZBTB34 for paralogs About GeneDecksing
|
Genomic Variants
for ZBTB34 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB34 (129622944 - 129648157 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ZBTB34
5 CNVs: 96304 83186 4656 4655 83187
1 Indel: 100785 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB34 |
|
Disorders
/ Diseases
for ZBTB34 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZBTB34 for disorders About MalaCards
ZBTB34 for disorders About GeneDecksing
OMIM gene information: 611692
OMIM disorders: --
Export disorders for ZBTB34 gene to outside databases
|
Publications
for ZBTB34 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB34 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZBTB34) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor. (PubMed id 16718364)1, 2, 3 Qi J.... Han Z.-G. (2006)
- Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)1, 2 Ohara O.... Koseki H. (2002)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZBTB34 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB34 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB34 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZBTB34 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB34 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB34 gene:
Search GeneIP for patents involving ZBTB34
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB34 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZBTB34 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB34 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB34 |
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