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ZBTB33 Gene

protein-coding   GIFtS: 54
GCID: GC0XP119384

Zinc Finger And BTB Domain Containing 33

  Search for ZBTB33
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 331 2     WUGSC:H_DJ525N14.12
Zinc Finger And BTB Domain-Containing Protein 332 3     ZNF-kaiso2
ZNF3482 3     Kaiso Transcription Factor2
KAISO3 5     Transcriptional Regulator Kaiso2

External Ids:    HGNC: 166821   Entrez Gene: 100092   Ensembl: ENSG000001774857   OMIM: 3003295   UniProtKB: Q86T243   

Export aliases for ZBTB33 gene to outside databases

Previous GC identifers: GC0XP118139 GC0XP119166 GC0XP119268 GC0XP108838


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZBTB33 Gene:
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG
and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB
domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone
deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to
the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of
target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1)
inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import
receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear
import of this protein. Alternatively spliced transcript variants encoding the same protein have been
identified.(provided by RefSeq, May 2010)

GeneCards Summary for ZBTB33 Gene:
ZBTB33 (zinc finger and BTB domain containing 33) is a protein-coding gene. An important paralog of this gene is ZBTB21.

UniProtKB/Swiss-Prot: KAISO_HUMAN, Q86T24
Function: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in
the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits
the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures
in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also
activate transcription of a subset of target genes by the recruitment of CTNND2

Gene Wiki entry for ZBTB33 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB33 gene promoter:
         p53   POU3F1   CUTL1   HNF-4alpha2   HNF-4alpha1   IRF-2   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB33 promoter sequence
   Search Chromatin IP Primers for ZBTB33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq23

ZBTB33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB33 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP119384:  view genomic region     (about GC identifiers)

Start:
119,384,607 bp from pter      End:
119,392,253 bp from pter
Size:
7,647 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KAISO_HUMAN, Q86T24 (See protein sequence)
Recommended Name: Transcriptional regulator Kaiso  
Size: 672 amino acids; 74484 Da
Subunit: Self-associates. Interacts with CTNND2 (By similarity). Interacts with CTNND1, and this interaction
inhibits binding to both methylated and non-methylated DNA. Interacts with NCOR1. Interacts with KPNA2/RCH1,
which may mediate nuclear import of this protein
6 PDB 3D structures from and Proteopedia for ZBTB33:
2LT7 (3D)        3FKC (3D)        3M4T (3D)        3M8V (3D)        4F6M (3D)        4F6N (3D)    
Secondary accessions: B2R5U6 O00319 Q7Z361 Q8IVP6 Q8N3P0

Explore the universe of human proteins at neXtProt for ZBTB33: NX_Q86T24

Explore proteomics data for ZBTB33 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys407, Lys529, Lys582
  • Modification sites at PhosphoSitePlus

  • See ZBTB33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171671.1  NP_006768.1  

    ENSEMBL proteins: 
     ENSP00000314153   ENSP00000450969  

    ZBTB33 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for ZBTB33 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q86T24

    ProtoNet protein and cluster: Q86T24

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: KAISO_HUMAN, Q86T24
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with ZBTB33           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAISO_HUMAN, Q86T24
    Function: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in
    the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits
    the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures
    in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also
    activate transcription of a subset of target genes by the recruitment of CTNND2
    Induction: Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress,
    which enhances wound closure

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding IPI16354688
    GO:0008327methyl-CpG binding IDA16354688
    GO:0043565sequence-specific DNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZBTB33           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zbtb33):
     mortality/aging  no phenotypic analysis  normal  tumorigenesis 

    Find genes that share phenotypes with ZBTB33           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zbtb33tm1.1Bird for ZBTB33

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZBTB33
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBTB33
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZBTB33

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GGNTCTCGCGAGAAC 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZBTB33:
    hsa-mir-93-5p (MIRT028064), hsa-mir-192-5p (MIRT026285), hsa-mir-215-5p (MIRT024596), hsa-mir-361-5p (MIRT044097), hsa-mir-186-5p (MIRT045104)

    Block miRNA regulation of human, mouse, rat ZBTB33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBTB33 (see all 75):
    hsa-miR-582-3p hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-106a hsa-miR-632 hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidZBTB33 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB33


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KAISO_HUMAN, Q86T24: Nucleus. Cytoplasm. Note=Also cytoplasmic in cells grown at high densities
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with ZBTB33           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZBTB33 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55


    1 BioSystems Pathway for ZBTB33
        Wnt Signaling Pathway and Pluripotency


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB33
    Interactions:

        GeneGlobe Interaction Network for ZBTB33

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ZBTB33 (Q86T242, 3 ENSP000003141534) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNND1O607163, ENSP000003820044I2D: score=6 STRING: ENSP00000382004
    RNF2Q994963, ENSP000003564804I2D: score=2 STRING: ENSP00000356480
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    CTNND2Q9UQB33, ENSP000003071344I2D: score=1 STRING: ENSP00000307134
    HDAC3O153793, ENSP000003029674I2D: score=1 STRING: ENSP00000302967
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0016055Wnt signaling pathway IEA--
    GO:0035556intracellular signal transduction TAS10207085
    GO:0045892negative regulation of transcription, DNA-templated IDA16354688

    Find genes that share ontologies with ZBTB33           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB33 (KAISO)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZBTB33 gene (2 alternative transcripts): 
    NM_001184742.1  NM_006777.3  

    Unigene Cluster for ZBTB33:

    Zinc finger and BTB domain containing 33
    Hs.143604  [show with all ESTs]
    Unigene Representative Sequence: NM_001184742
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326624(uc010nqm.1 uc004esn.1) ENST00000557385
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZBTB33 (see all 75):
    hsa-miR-582-3p hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-106a hsa-miR-632 hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidZBTB33 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ZBTB33

    Additional mRNA sequence: 

    AK092998.1 AK094230.1 AK312321.1 AL833604.1 AL833856.1 BC042753.1 BX538016.1 BX538101.1 

    6 DOTS entries:

    DT.413928  DT.121301268  DT.121301263  DT.100721641  DT.121301271  DT.95237159 

    Selected AceView cDNA sequences (see all 121):

    BX092275 BE018480 T61211 AA279190 CB148666 BP335246 BF971259 NM_006777 
    AA463633 AA482006 BQ945983 BX955913 AK094230 CF593941 BM786592 BF512729 
    AI762551 BE302089 BE790431 AL833856 AA443179 BF514257 BU172925 BC042753 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB33    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for ZBTB33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBTB33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGATATT
    ZBTB33 Expression
    About this image

    ZBTB33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB33 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143604

    UniProtKB/Swiss-Prot: KAISO_HUMAN, Q86T24
    Tissue specificity: Expressed in vascular endothelium

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB33 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb331 , 5 zinc finger and BTB domain containing 331, 5 88.29(n)1
    87(a)1
      X (22.45 cM)5
    568051  NM_020256.21  NP_064652.21 
     381898125 
    chicken
    (Gallus gallus)
    Aves ZBTB331 zinc finger and BTB domain containing 33 66.97(n)
    64.11(a)
      422367  NM_001079729.1  NP_001073197.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB336
    zinc finger and BTB domain containing 33
    56(a)
    1 ↔ 1
    GL343950.1(54064-64636)
    African clawed frog
    (Xenopus laevis)
    Amphibia Kaiso2 DNA-methylation dependent transcriptional repressor more 77.14(n)    AF420316.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zbtb331 zinc finger and BTB domain containing 33 59.72(n)
    57.4(a)
      562507  NM_001100008.1  NP_001093478.1 


    ENSEMBL Gene Tree for ZBTB33 (if available)
    TreeFam Gene Tree for ZBTB33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBTB33 gene
    ZBTB212  ZBTB382  ZBTB142  ZBTB7C2  ZBTB7A2  ZBTB7B2  ZBTB42  

    Find genes that share paralogs with ZBTB33           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZBTB33 (see all 128)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875743491,2
    --108835110(+) GTTAGC/GGGGTG 2 -- us2k10--------
    rs1396540541,2
    --119376432(+) TAAAAG/TACTTT 2 -- us2k10--------
    rs1915046221,2
    --119376509(+) AAATTC/GCATTG 2 -- us2k10--------
    rs736076531,2
    C,F--119376584(+) GTGATC/ATGTAT 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1838089101,2
    --119376719(+) GAGGAA/TAACTC 2 -- us2k10--------
    rs1443814321,2
    --119376842(+) AACTTC/TTCATA 2 -- us2k10--------
    rs1869825961,2
    --119376917(+) CAAAAC/TCTTGG 2 -- us2k10--------
    rs1997347211,2
    --119377647(+) TCTCT-/TCTC  
            
    TCTGC
    2 -- us2k10--------
    rs1918625111,2
    --119377749(+) TTTTGC/TATTCC 2 -- us2k10--------
    rs1825322161,2
    --119377815(+) AGTTGC/GAATGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZBTB33 (119384607 - 119392253 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZBTB33: --
    Locus Specific Mutation Databases (LSDB): ZBTB33

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB33
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300329    OMIM disorders: --


    Find genes that share disorders with ZBTB33           About GenesLikeMe


    Export disorders for ZBTB33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBTB33 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with ZBTB33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nuclear import of the BTB/POZ transcriptional regulator Kaiso. (PubMed id 15564377)1, 2, 9 Kelly K.F.... Daniel J.M. (J. Cell Sci. 2004)
    2. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. (PubMed id 11445535)1, 2, 9 Prokhortchouk A.... Prokhortchouk E. (Genes Dev. 2001)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment. (PubMed id 15781635)1, 2 Soubry A.... van Roy F. (Cancer Res. 2005)
    5. The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. (PubMed id 15817151)1, 2 Spring C.M....Daniel J.M. (Exp. Cell Res. 2005)
    6. Kaiso is a genome-wide repressor of transcription that is essential for amphibian development. (PubMed id 15548582)1, 2 Ruzov A.... Meehan R.R. (Development 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells. (PubMed id 14699141)1, 2 Kondapalli J.... Albuquerque M.L.C. (J. Biol. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. (PubMed id 14527417)1, 2 Yoon H.-G.... Wong J. (Mol. Cell 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10009 HGNC: 16682 AceView: ZBTB33 Ensembl:ENSG00000177485 euGenes: HUgn10009
    ECgene: ZBTB33 H-InvDB: ZBTB33

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZBTB33 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZBTB33 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZBTB33 gene:
    Search GeneIP for patents involving ZBTB33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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