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Aliases for ZBTB33 Gene

Aliases for ZBTB33 Gene

  • Zinc Finger And BTB Domain Containing 33 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 33 3 4
  • ZNF348 3 4
  • Transcriptional Regulator Kaiso 3
  • Kaiso Transcription Factor 3
  • WUGSC:H_DJ525N14.1 3
  • ZNF-Kaiso 3
  • KAISO 4

External Ids for ZBTB33 Gene

Previous GeneCards Identifiers for ZBTB33 Gene

  • GC0XP118139
  • GC0XP119166
  • GC0XP119268
  • GC0XP119384
  • GC0XP108838

Summaries for ZBTB33 Gene

Entrez Gene Summary for ZBTB33 Gene

  • This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]

GeneCards Summary for ZBTB33 Gene

ZBTB33 (Zinc Finger And BTB Domain Containing 33) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathway and Pluripotency. GO annotations related to this gene include sequence-specific DNA binding and methyl-CpG binding. An important paralog of this gene is ZBTB38.

UniProtKB/Swiss-Prot for ZBTB33 Gene

  • Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5-CGCG-3 and also binds to the non-methylated consensus sequence 5-CTGCNA-3 also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).

Gene Wiki entry for ZBTB33 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB33 Gene

Genomics for ZBTB33 Gene

Regulatory Elements for ZBTB33 Gene

Enhancers for ZBTB33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG120309 1.3 Ensembl ENCODE 12.7 +59.4 59449 2.4 PKNOX1 ARNT ARID4B FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 SP3 NKAPP1 UPF3B EEF1A1P30 ZBTB33 NKAP CXorf56 TMEM255A ENSG00000232042
GH0XG120305 1 FANTOM5 dbSUPER 12.7 +55.2 55184 0.2 ZNF639 MAZ ATF1 ZNF398 ZNF518A ATF2 OSR2 JUND ATF3 ZNF366 ZBTB33 NKAPP1 TMEM255A ENSG00000232042
GH0XG120275 0.8 ENCODE 13.1 +24.4 24449 0.2 ZFP64 TEAD4 ZNF140 ZNF266 ZNF101 ZNF697 ZNF664 ZNF354C GLI2 KLF7 ZBTB33 NKAPP1 ATP1B4 LAMP2 ENSG00000232042 TMEM255A
GH0XG120304 0.7 Ensembl dbSUPER 12.7 +53.9 53949 1.0 RNF2 NFE2 ZBTB33 NKAPP1 TMEM255A SLC25A43 ENSG00000232042
GH0XG120308 0.4 ENCODE 12.7 +58.0 58039 0.1 CTCF EGR2 ZBTB33 NKAPP1 TMEM255A ENSG00000232042
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB33 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248403 449 2400 HDGF PKNOX1 ATF1 MLX CREB3L1 ARID4B SIN3A ZNF48 YY1 ZNF143

Genomic Location for ZBTB33 Gene

Chromosome:
X
Start:
120,250,752 bp from pter
End:
120,258,398 bp from pter
Size:
7,647 bases
Orientation:
Plus strand

Genomic View for ZBTB33 Gene

Genes around ZBTB33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB33 Gene

Proteins for ZBTB33 Gene

  • Protein details for ZBTB33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T24-KAISO_HUMAN
    Recommended name:
    Transcriptional regulator Kaiso
    Protein Accession:
    Q86T24
    Secondary Accessions:
    • B2R5U6
    • O00319
    • Q7Z361
    • Q8IVP6
    • Q8N3P0

    Protein attributes for ZBTB33 Gene

    Size:
    672 amino acids
    Molecular mass:
    74484 Da
    Quaternary structure:
    • Self-associates. Interacts with CTNND2 (By similarity). Interacts with CTNND1, and this interaction inhibits binding to both methylated and non-methylated DNA. Interacts with NCOR1. Interacts with KPNA2/RCH1, which may mediate nuclear import of this protein. Interacts with CBFA2T3.

    Three dimensional structures from OCA and Proteopedia for ZBTB33 Gene

neXtProt entry for ZBTB33 Gene

Post-translational modifications for ZBTB33 Gene

  • Ubiquitination at posLast=407407, isoforms=529, and posLast=582582
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBTB33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB33 Gene

Domains & Families for ZBTB33 Gene

Gene Families for ZBTB33 Gene

Protein Domains for ZBTB33 Gene

Suggested Antigen Peptide Sequences for ZBTB33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB33: view

No data available for UniProtKB/Swiss-Prot for ZBTB33 Gene

Function for ZBTB33 Gene

Molecular function for ZBTB33 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5-CGCG-3 and also binds to the non-methylated consensus sequence 5-CTGCNA-3 also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
UniProtKB/Swiss-Prot Induction:
Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.

Gene Ontology (GO) - Molecular Function for ZBTB33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16354688
GO:0008327 methyl-CpG binding IDA 16354688
GO:0043565 sequence-specific DNA binding IDA 20403812
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB33: view
genes like me logo Genes that share phenotypes with ZBTB33: view

Animal Models for ZBTB33 Gene

MGI Knock Outs for ZBTB33:

Animal Model Products

CRISPR Products

miRNA for ZBTB33 Gene

miRTarBase miRNAs that target ZBTB33
Targeted motifs for ZBTB33 Gene
HOMER Transcription Factor Regulatory Elements motif ZBTB33
  • Consensus sequence: GGNTCTCGCGAGAAC Submotif: canonical Cell Type: GM12878 GEO ID: GSE32465

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ZBTB33 Gene

Localization for ZBTB33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB33 Gene

Nucleus. Cytoplasm. Note=Also cytoplasmic in cells grown at high densities.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB33 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZBTB33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZBTB33: view

Pathways & Interactions for ZBTB33 Gene

genes like me logo Genes that share pathways with ZBTB33: view

Pathways by source for ZBTB33 Gene

1 BioSystems pathway for ZBTB33 Gene

SIGNOR curated interactions for ZBTB33 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZBTB33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0035556 intracellular signal transduction TAS 10207085
GO:0045892 negative regulation of transcription, DNA-templated IMP 23251453
genes like me logo Genes that share ontologies with ZBTB33: view

Transcripts for ZBTB33 Gene

mRNA/cDNA for ZBTB33 Gene

Unigene Clusters for ZBTB33 Gene

Zinc finger and BTB domain containing 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB33 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for ZBTB33 Gene

GeneLoc Exon Structure for
ZBTB33
ECgene alternative splicing isoforms for
ZBTB33

Expression for ZBTB33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB33 Gene

Protein differential expression in normal tissues from HIPED for ZBTB33 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.5), Blymphocyte (15.7), CD8 Tcells (11.1), and CD4 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB33 Gene



Protein tissue co-expression partners for ZBTB33 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB33 Gene:

ZBTB33

SOURCE GeneReport for Unigene cluster for ZBTB33 Gene:

Hs.143604

mRNA Expression by UniProt/SwissProt for ZBTB33 Gene:

Q86T24-KAISO_HUMAN
Tissue specificity: Expressed in vascular endothelium.

Evidence on tissue expression from TISSUES for ZBTB33 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZBTB33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB33 Gene

Orthologs for ZBTB33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB33 34 35
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia MGC155143 35
  • 94 (a)
OneToOne
ZBTB33 34
  • 92.48 (n)
dog
(Canis familiaris)
Mammalia ZBTB33 34 35
  • 92.56 (n)
mouse
(Mus musculus)
Mammalia Zbtb33 34 16 35
  • 88.29 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910807 34
  • 87.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB33 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB33 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB33 34 35
  • 66.97 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB33 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb33 34
  • 63.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia Kaiso 34
zebrafish
(Danio rerio)
Actinopterygii zbtb33 34 35
  • 59.72 (n)
Species where no ortholog for ZBTB33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB33 Gene

ENSEMBL:
Gene Tree for ZBTB33 (if available)
TreeFam:
Gene Tree for ZBTB33 (if available)

Paralogs for ZBTB33 Gene

Paralogs for ZBTB33 Gene

genes like me logo Genes that share paralogs with ZBTB33: view

Variants for ZBTB33 Gene

Sequence variations from dbSNP and Humsavar for ZBTB33 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1057518570 Uncertain significance 120,253,452(+) ACATT(C/G)AGTAC intron-variant, reference, missense
rs1000278739 -- 120,252,114(+) TTAGA(C/T)TTTTT intron-variant
rs1000415724 -- 120,252,665(+) TCATG(A/G)TAGTG intron-variant
rs1000725191 -- 120,255,428(+) GAGTC(G/T)TACTA intron-variant, reference, synonymous-codon
rs1001363018 -- 120,249,860(+) TTTTT(C/T)GGTCA upstream-variant-2KB

Variation tolerance for ZBTB33 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB33 Gene

Human Gene Mutation Database (HGMD)
ZBTB33
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB33 Gene

Disorders for ZBTB33 Gene

Relevant External Links for ZBTB33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB33

No disorders were found for ZBTB33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB33 Gene

Publications for ZBTB33 Gene

  1. Nuclear import of the BTB/POZ transcriptional regulator Kaiso. (PMID: 15564377) Kelly K.F. … Daniel J.M. (J. Cell Sci. 2004) 3 4 22 64
  2. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. (PMID: 11445535) Prokhortchouk A. … Prokhortchouk E. (Genes Dev. 2001) 3 4 22 64
  3. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. (PMID: 23251453) Barrett C.W. … Williams C.S. (PLoS ONE 2012) 3 4 64
  4. A family of human zinc finger proteins that bind methylated DNA and repress transcription. (PMID: 16354688) Filion G.J. … Defossez P.A. (Mol. Cell. Biol. 2006) 3 4 64
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64

Products for ZBTB33 Gene

Sources for ZBTB33 Gene

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