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Aliases for ZBTB32 Gene

Aliases for ZBTB32 Gene

  • Zinc Finger And BTB Domain Containing 32 2 3 5
  • Fanconi Anemia Zinc Finger Protein 3 4
  • Testis Zinc Finger Protein 3 4
  • FANCC-Interacting Protein 3 4
  • Zinc Finger Protein 538 3 4
  • Repressor Of GATA 2 3
  • ZNF538 3 4
  • FAZF 3 4
  • TZFP 3 4
  • Zinc Finger And BTB Domain-Containing Protein 32 3
  • FAXF 3
  • Rog 3

External Ids for ZBTB32 Gene

Previous GeneCards Identifiers for ZBTB32 Gene

  • GC19P040896
  • GC19P036203
  • GC19P032708
  • GC19P036201
  • GC19P035779
  • GC19P035829
  • GC19P035846
  • GC19P036005
  • GC19P036168
  • GC19P036241
  • GC19P036410

Summaries for ZBTB32 Gene

GeneCards Summary for ZBTB32 Gene

ZBTB32 (Zinc Finger And BTB Domain Containing 32) is a Protein Coding gene. Diseases associated with ZBTB32 include Fanconi Anemia, Complementation Group A. Among its related pathways are DNA Double-Strand Break Repair and Fanconi anemia pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is ZBTB16.

UniProtKB/Swiss-Prot for ZBTB32 Gene

  • DNA-binding protein that binds to the to a 5-TGTACAGTGT-3 core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).

Gene Wiki entry for ZBTB32 Gene

Additional gene information for ZBTB32 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB32 Gene

Genomics for ZBTB32 Gene

GeneHancer (GH) Regulatory Elements for ZBTB32 Gene

Promoters and enhancers for ZBTB32 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I035710 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565.7 +10.7 10701 10 ZFP64 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 ZNF263 SP3 ZFP41 KMT2B ZBTB32 PIR52641 ZNF529 ZNF567 ZNF461 TMEM147-AS1 ZNF599 LINC01534 ZFP82
GH19I035701 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 574 -1.9 -1891 1.6 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 ZNF2 ZNF416 ZNF143 ZNF548 ZBTB32 ZNF567 PROSER3 TMEM147-AS1 ZNF599 HAUS5 U2AF1L4 KMT2B ENSG00000267049 ZNF792
GH19I036213 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.5 +510.8 510817 3.3 MLX YBX1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZNF146 ZNF565 ZNF345 ZNF567 TMEM147-AS1 ZNF850 HAUS5 ZNF790 ZNF260 ZNF529
GH19I035753 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.6 +51.8 51766 6.4 HDGF PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 PROSER3 HSPB6 GC19M038818 ENSG00000267328 U2AF1L4 COX6B1 ZBTB32 ENSG00000267049 KMT2B ENSG00000261754
GH19I036013 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.7 +309.7 309745 2.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 POLR2B LOC101927572 ALKBH6 ENSG00000248101 ZNF345 ZNF850 KMT2B ZNF567 PROSER3 TMEM147-AS1 RBM42
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB32 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZBTB32 gene promoter:

Genomic Locations for ZBTB32 Gene

Genomic Locations for ZBTB32 Gene
chr19:35,704,492-35,717,048
(GRCh38/hg38)
Size:
12,557 bases
Orientation:
Plus strand
chr19:36,195,429-36,207,940
(GRCh37/hg19)

Genomic View for ZBTB32 Gene

Genes around ZBTB32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB32 Gene

Proteins for ZBTB32 Gene

  • Protein details for ZBTB32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Y4-ZBT32_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 32
    Protein Accession:
    Q9Y2Y4
    Secondary Accessions:
    • Q8WVP2

    Protein attributes for ZBTB32 Gene

    Size:
    487 amino acids
    Molecular mass:
    52963 Da
    Quaternary structure:
    • Homodimer (via PTB domain). Interacts with the N-terminal of FANCC. Interacts with ZBTB16. Interacts with GATA3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for ZBTB32 Gene

neXtProt entry for ZBTB32 Gene

Post-translational modifications for ZBTB32 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZBTB32 Gene

Domains & Families for ZBTB32 Gene

Gene Families for ZBTB32 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB32 Gene

Suggested Antigen Peptide Sequences for ZBTB32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2Y4

UniProtKB/Swiss-Prot:

ZBT32_HUMAN :
  • The C-terminal zinc finger domain functions as a transcriptional transactivator.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The C-terminal zinc finger domain functions as a transcriptional transactivator.
  • The BTB (POZ) domain possesses repressor activity.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB32: view

Function for ZBTB32 Gene

Molecular function for ZBTB32 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that binds to the to a 5-TGTACAGTGT-3 core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).

Phenotypes From GWAS Catalog for ZBTB32 Gene

Gene Ontology (GO) - Molecular Function for ZBTB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding ISS --
GO:0003714 transcription corepressor activity TAS 10572087
GO:0005515 protein binding IPI 23088713
GO:0008270 zinc ion binding ISS --
genes like me logo Genes that share ontologies with ZBTB32: view
genes like me logo Genes that share phenotypes with ZBTB32: view

Animal Models for ZBTB32 Gene

MGI Knock Outs for ZBTB32:

miRNA for ZBTB32 Gene

miRTarBase miRNAs that target ZBTB32

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB32 Gene

Localization for ZBTB32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB32 Gene

Nucleus. Note=Located in nuclear speckles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB32 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZBTB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10572087
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZBTB32: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB32 Gene

Pathways & Interactions for ZBTB32 Gene

genes like me logo Genes that share pathways with ZBTB32: view

Pathways by source for ZBTB32 Gene

Gene Ontology (GO) - Biological Process for ZBTB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 10572087
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 10572087
GO:0036297 interstrand cross-link repair TAS --
genes like me logo Genes that share ontologies with ZBTB32: view

No data available for SIGNOR curated interactions for ZBTB32 Gene

Drugs & Compounds for ZBTB32 Gene

(1) Drugs for ZBTB32 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZBTB32: view

Transcripts for ZBTB32 Gene

Unigene Clusters for ZBTB32 Gene

Zinc finger and BTB domain containing 32:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB32 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for ZBTB32 Gene

GeneLoc Exon Structure for
ZBTB32
ECgene alternative splicing isoforms for
ZBTB32

Expression for ZBTB32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB32 Gene

This gene is overexpressed in Testis (x18.6).

Protein differential expression in normal tissues from HIPED for ZBTB32 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB32 Gene



Protein tissue co-expression partners for ZBTB32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB32 Gene:

ZBTB32

SOURCE GeneReport for Unigene cluster for ZBTB32 Gene:

Hs.99430

mRNA Expression by UniProt/SwissProt for ZBTB32 Gene:

Q9Y2Y4-ZBT32_HUMAN
Tissue specificity: Predominantly expressed in testis. Some isoforms are ubiquitously expressed.
genes like me logo Genes that share expression patterns with ZBTB32: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB32 Gene

Orthologs for ZBTB32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB32 33 34
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia ZBTB32 33 34
  • 84.69 (n)
dog
(Canis familiaris)
Mammalia ZBTB32 33
  • 84.4 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb32 33
  • 77.97 (n)
mouse
(Mus musculus)
Mammalia Zbtb32 33 16 34
  • 77.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB32 34
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ZBTB32 (1 of 2) 34
  • 52 (a)
OneToMany
ZBTB32 (2 of 2) 34
  • 19 (a)
OneToMany
Species where no ortholog for ZBTB32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB32 Gene

ENSEMBL:
Gene Tree for ZBTB32 (if available)
TreeFam:
Gene Tree for ZBTB32 (if available)

Paralogs for ZBTB32 Gene

Paralogs for ZBTB32 Gene

genes like me logo Genes that share paralogs with ZBTB32: view

Variants for ZBTB32 Gene

Sequence variations from dbSNP and Humsavar for ZBTB32 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000031603 -- 35,711,762(+) C/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000101691 -- 35,711,332(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000379143 -- 35,704,923(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000386224 -- 35,717,542(+) G/A downstream_transcript_variant
rs1000937637 -- 35,713,317(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB32 Gene

Variant ID Type Subtype PubMed ID
esv3644242 CNV gain 21293372
nsv579422 CNV loss 21841781
nsv828544 CNV gain 20364138

Variation tolerance for ZBTB32 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB32 Gene

Disorders for ZBTB32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBTB32 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
fanconi anemia, complementation group a
  • fanca
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZBTB32

genes like me logo Genes that share disorders with ZBTB32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB32 Gene

Publications for ZBTB32 Gene

  1. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. (PMID: 10572087) Hoatlin ME … Licht JD (Blood 1999) 2 3 4 58
  2. Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP. (PMID: 10544010) Lin W … Tang TK (Biochemical and biophysical research communications 1999) 3 4 22 58
  3. Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. (PMID: 20493880) Stogios PJ … Privé GG (Journal of molecular biology 2010) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein. (PMID: 11964310) Tsuzuki S … Enver T (Blood 2002) 3 22 58

Products for ZBTB32 Gene

Sources for ZBTB32 Gene

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