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Aliases & Descriptions for ZBTB32
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FAXF 1, 2, 5 | | FAZF 1, 2, 3 | | OTTHUMP00000045790 2 | | ROG 5 | | Rog 1, 2 | | TZFP 1, 2, 3, 5 | | ZNF538 1, 2 |
| | | Descriptions |
|---|
| FANCC-interacting protein 3 | | Fanconi anemia zinc finger protein 3 | | Testis zinc finger protein 2, 3 | | repressor of GATA 2 | | zinc finger and BTB domain containing 32 2 |
|
| | Search outside databases for aliases for ZBTB32 gene |
Summaries for ZBTB32(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZBT32_HUMAN, Q9Y2Y4Function: DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T cells (By similarity)Gene Wiki entry for ZBTB32 |
Genomic Location for ZBTB32
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ZBTB32 gene 
Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1ZBTB32 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P040896:
(about GC identifiers)
Start:
|
40,895,670 bp from pter |
End:
|
40,899,780 bp from pter |
Size:
|
4,111 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for ZBTB32
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZBT32_HUMAN, Q9Y2Y4 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 32 Size: 487 amino acids; 52963 Da
Subunit: Interacts with the N-terminal of FANCC. Interacts with ZBTB16. Interacts with GATA3 (By similarity)
Subcellular location: Nucleus. Note=Located in nuclear speckles
Secondary accessions: Q8WVP2REFSEQ proteins: NP_055198.1
ENSEMBL proteins: ENSP00000345954 ENSP00000376035 ENSP00000262630
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ZBTB32: Assays for ZBTB32: | Protein
Domains/ Families for ZBTB32(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y2Y4
ProtoNet protein and cluster: Q9Y2Y4 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT32_HUMAN, Q9Y2Y4Domain: The C-terminal zinc finger domain functions as a transcriptional transactivator (By similarity)Domain: The BTB (POZ) domain possesses repressor activity (By similarity)Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 3 C2H2-type zinc fingers | Gene Function for ZBTB32
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014383
Applied Biosystems Silencer® siRNAs for ZBTB32
Sigma-Aldrich siRNA and siRNA Panels for ZBTB32  Sigma-Aldrich shRNA for ZBTB32  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014383                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014383                                  untagged cDNA clone in CMV expression vector: NM_014383 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014383
UniProtKB/Swiss-Prot: ZBT32_HUMAN, Q9Y2Y4Function: DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T cells (By similarity)3 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Zbtb32):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for ZBTB32
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/12 Interacting proteins for ZBTB32 (Q9Y2Y42 ENSP000002626303) via UniProtKB, MINT, and/or STRING (see all 12
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | 10572087 | | GO:0001817 | regulation of cytokine production |
IEA | -- | | GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0030097 | hemopoiesis |
IEA | -- | About this table
|
Drugs & Compounds for ZBTB32(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ZBTB32 1 Novoseek chemical compound relationship for ZBTB32 gene
About this table
|
Transcripts for ZBTB32(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014383
Sigma-Aldrich siRNA and siRNA Panels for ZBTB32  Sigma-Aldrich shRNA for ZBTB32  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014383 REFSEQ mRNAs for ZBTB32 gene: NM_014383.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014383               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014383                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014383                                  untagged cDNA clone in CMV expression vector: NM_014383  Additional cDNA sequence: AF130255.1 AF165097.1 BC017700.2 4 DOTS entries: DT.208787 DT.91890193 DT.100737697 DT.91813092 24/41 AceView cDNA sequences (see all 41
):NM_014383 BE674864 H48938 BC017700 BM563565 AF130255 BX095236 AF165097 AI807480 BI825896 BI825319 AI150041 AI540057 BF980407 BG177331 BG724348 BI828090 AI150330 BI826750 BI826880 BG717422 AI223414 BG771476 AI798147
highest scoring ESTs for ZBTB32:AI798147 AA456628 AA476210 AA868505 AA927876 AF130255 AF165097 AI150041 AI150330 AI223414 Unigene Cluster for ZBTB32: Zinc finger and BTB domain containing 32 Hs.99430 [show with all ESTs]Unigene Representative Sequence: NM_014383
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB32
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ZBTB32
3 Ensembl transcripts including schematic representations: ENST00000354109
ENST00000392197
ENST00000262630
|
Expression for ZBTB32
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZBTB32 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB32
1 / 2 / 3 4 probe-sets matching ZBTB32 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CGCGGTCACT
SOURCE GeneReport for Unigene cluster: Hs.99430 UniProtKB/Swiss-Prot: ZBT32_HUMAN, Q9Y2Y4Tissue specificity: Predominantly expressed in testis. Some isoforms are ubiquitously expressed |
Orthologs for ZBTB32
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZBTB32 gene from 5 species
About this table Species with no ortholog for ZBTB32
ENSEMBL Gene Tree for ZBTB32 | Paralogs for ZBTB32(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ZBTB32 gene
- ZBTB392 ZBTB162
|
SNPs/Variants for ZBTB32(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ZBTB32 (up to first 250kb)
|
Disorders & Mutations for ZBTB32
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605859
1 Novoseek disease relationship for ZBTB32 gene
About this table
|
Medical News for ZBTB32(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ZBTB32 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for ZBTB32 gene (see all 14
):- A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. (PubMed id 10572087)2, 3, 4 Hoatlin M.E.... Licht J.D. (1999)
- Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP. (PubMed id 10544010)1, 3, 4 Lin W.-C.... Tang T.K. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein. (PubMed id 11964310)1, 3 Tsuzuki S. and Enver T. (2002)
- Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation. (PubMed id 17171645)3 Ikeda R....Inoue I. (2007)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)3 Lim J....Zoghbi H.Y. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
- Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. (PubMed id 14499622)3 Reuter T.Y....Huber P.A. (2003)
- VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. (PubMed id 12821938)3 Han S.H.... Choi I. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for ZBTB32
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZBTB32
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZBTB32
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB32(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ZBTB32(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ZBTB32:

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Incremental update: 13 Oct 2009
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