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Aliases for ZBTB32 Gene

Aliases for ZBTB32 Gene

  • Zinc Finger And BTB Domain Containing 32 2 3 5
  • Fanconi Anemia Zinc Finger Protein 3 4
  • Testis Zinc Finger Protein 3 4
  • FANCC-Interacting Protein 3 4
  • Zinc Finger Protein 538 3 4
  • Repressor Of GATA 2 3
  • ZNF538 3 4
  • FAZF 3 4
  • TZFP 3 4
  • Zinc Finger And BTB Domain-Containing Protein 32 3
  • FAXF 3
  • Rog 3

External Ids for ZBTB32 Gene

Previous GeneCards Identifiers for ZBTB32 Gene

  • GC19P040896
  • GC19P036203
  • GC19P032708
  • GC19P036201
  • GC19P035779
  • GC19P035829
  • GC19P035846
  • GC19P036005
  • GC19P036168

Summaries for ZBTB32 Gene

GeneCards Summary for ZBTB32 Gene

ZBTB32 (Zinc Finger And BTB Domain Containing 32) is a Protein Coding gene. Diseases associated with ZBTB32 include Fanconi Anemia, Complementation Group A. Among its related pathways are Fanconi anemia pathway and Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is ZBTB16.

UniProtKB/Swiss-Prot for ZBTB32 Gene

  • DNA-binding protein that binds to the to a 5-TGTACAGTGT-3 core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).

Gene Wiki entry for ZBTB32 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB32 Gene

Genomics for ZBTB32 Gene

Regulatory Elements for ZBTB32 Gene

Enhancers for ZBTB32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G035710 2 FANTOM5 Ensembl ENCODE dbSUPER 15.7 +10.7 10701 10.0 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 TBX21 ZFP41 ZFP82 ZNF529 U2AF1L4 TMEM147-AS1 LINC00665 ZNF461 ZNF567 COX6B1 ZNF792 ZNF529-AS1
GH19G035753 1.4 ENCODE dbSUPER 9.5 +51.8 51766 6.4 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 U2AF1L4 COX6B1 ZBTB32 ENSG00000267049 GC19M038228 HSPB6
GH19G035701 2 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -1.9 -1892 1.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZNF416 ZNF143 ZNF548 FOS ZNF567 TMEM147-AS1 U2AF1L4 HAUS5 ZNF792 KMT2B RBM42 COX6B1 ZNF146 LRFN3
GH19G035328 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -373.5 -373458 5.1 HDGF FOXA2 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF416 TMEM147-AS1 MAG KMT2B ZNF792 ZNF146 RBM42 CD22 ENSG00000271032 KRTDAP DMKN
GH19G035641 1.7 FANTOM5 ENCODE dbSUPER 5.1 -61.0 -60962 4.6 MLX CREB3L1 AGO1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF529 ZFP82 TMEM147-AS1 ZNF792 RBM42 KMT2B ZFP14 CTBP2P7 ENSG00000267049 ZNF260
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB32 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB32 Gene

Chromosome:
19
Start:
35,704,492 bp from pter
End:
35,717,048 bp from pter
Size:
12,557 bases
Orientation:
Plus strand

Genomic View for ZBTB32 Gene

Genes around ZBTB32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB32 Gene

Proteins for ZBTB32 Gene

  • Protein details for ZBTB32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Y4-ZBT32_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 32
    Protein Accession:
    Q9Y2Y4
    Secondary Accessions:
    • Q8WVP2

    Protein attributes for ZBTB32 Gene

    Size:
    487 amino acids
    Molecular mass:
    52963 Da
    Quaternary structure:
    • Homodimer (via PTB domain). Interacts with the N-terminal of FANCC. Interacts with ZBTB16. Interacts with GATA3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for ZBTB32 Gene

neXtProt entry for ZBTB32 Gene

Post-translational modifications for ZBTB32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB32 Gene

Domains & Families for ZBTB32 Gene

Gene Families for ZBTB32 Gene

Suggested Antigen Peptide Sequences for ZBTB32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2Y4

UniProtKB/Swiss-Prot:

ZBT32_HUMAN :
  • The C-terminal zinc finger domain functions as a transcriptional transactivator.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The C-terminal zinc finger domain functions as a transcriptional transactivator.
  • The BTB (POZ) domain possesses repressor activity.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB32: view

Function for ZBTB32 Gene

Molecular function for ZBTB32 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that binds to the to a 5-TGTACAGTGT-3 core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).

Gene Ontology (GO) - Molecular Function for ZBTB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding ISS --
GO:0003714 transcription corepressor activity TAS 10572087
GO:0005515 protein binding IPI 23088713
GO:0008270 zinc ion binding ISS --
genes like me logo Genes that share ontologies with ZBTB32: view
genes like me logo Genes that share phenotypes with ZBTB32: view

Animal Models for ZBTB32 Gene

MGI Knock Outs for ZBTB32:

Animal Model Products

miRNA for ZBTB32 Gene

miRTarBase miRNAs that target ZBTB32

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB32 Gene

Localization for ZBTB32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB32 Gene

Nucleus. Note=Located in nuclear speckles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB32 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZBTB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10572087
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZBTB32: view

Pathways & Interactions for ZBTB32 Gene

genes like me logo Genes that share pathways with ZBTB32: view

Pathways by source for ZBTB32 Gene

Gene Ontology (GO) - Biological Process for ZBTB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 10572087
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10572087
GO:0036297 interstrand cross-link repair TAS --
genes like me logo Genes that share ontologies with ZBTB32: view

No data available for SIGNOR curated interactions for ZBTB32 Gene

Drugs & Compounds for ZBTB32 Gene

(1) Drugs for ZBTB32 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZBTB32: view

Transcripts for ZBTB32 Gene

Unigene Clusters for ZBTB32 Gene

Zinc finger and BTB domain containing 32:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB32 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for ZBTB32 Gene

GeneLoc Exon Structure for
ZBTB32
ECgene alternative splicing isoforms for
ZBTB32

Expression for ZBTB32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB32 Gene

This gene is overexpressed in Testis (x18.6).

Protein differential expression in normal tissues from HIPED for ZBTB32 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB32 Gene



Protein tissue co-expression partners for ZBTB32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB32 Gene:

ZBTB32

SOURCE GeneReport for Unigene cluster for ZBTB32 Gene:

Hs.99430

mRNA Expression by UniProt/SwissProt for ZBTB32 Gene:

Q9Y2Y4-ZBT32_HUMAN
Tissue specificity: Predominantly expressed in testis. Some isoforms are ubiquitously expressed.
genes like me logo Genes that share expression patterns with ZBTB32: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB32 Gene

Orthologs for ZBTB32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB32 34 35
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia ZBTB32 34 35
  • 84.69 (n)
dog
(Canis familiaris)
Mammalia ZBTB32 34
  • 84.4 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb32 34
  • 77.97 (n)
mouse
(Mus musculus)
Mammalia Zbtb32 34 16 35
  • 77.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB32 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ZBTB32 (1 of 2) 35
  • 52 (a)
OneToMany
ZBTB32 (2 of 2) 35
  • 19 (a)
OneToMany
Species where no ortholog for ZBTB32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB32 Gene

ENSEMBL:
Gene Tree for ZBTB32 (if available)
TreeFam:
Gene Tree for ZBTB32 (if available)

Paralogs for ZBTB32 Gene

Paralogs for ZBTB32 Gene

genes like me logo Genes that share paralogs with ZBTB32: view

Variants for ZBTB32 Gene

Sequence variations from dbSNP and Humsavar for ZBTB32 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000031603 -- 35,711,762(+) GAGGC(C/T)GGGCG intron-variant, upstream-variant-2KB
rs1000101691 -- 35,711,332(+) AGGGT(A/G)TTTCC intron-variant, upstream-variant-2KB
rs1000379143 -- 35,704,923(+) ATGAG(A/G)TATGG intron-variant
rs1000386224 -- 35,717,542(+) TCGGG(A/G)GTCCC downstream-variant-500B, upstream-variant-2KB
rs1000937637 -- 35,713,317(+) CCTTC(A/G)GGGGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZBTB32 Gene

Variant ID Type Subtype PubMed ID
esv3644242 CNV gain 21293372
nsv579422 CNV loss 21841781
nsv828544 CNV gain 20364138

Variation tolerance for ZBTB32 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB32 Gene

Disorders for ZBTB32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBTB32 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fanconi anemia, complementation group a
  • fanconi's anemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZBTB32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB32
genes like me logo Genes that share disorders with ZBTB32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB32 Gene

Publications for ZBTB32 Gene

  1. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. (PMID: 10572087) Hoatlin M.E. … Licht J.D. (Blood 1999) 2 3 4 64
  2. Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP. (PMID: 10544010) Lin W.-C. … Tang T.K. (Biochem. Biophys. Res. Commun. 1999) 3 4 22 64
  3. Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. (PMID: 20493880) Stogios P.J. … Prive G.G. (J. Mol. Biol. 2010) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein. (PMID: 11964310) Tsuzuki S. … Enver T. (Blood 2002) 3 22 64

Products for ZBTB32 Gene

Sources for ZBTB32 Gene

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